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Conserved domains on  [gi|24585269|ref|NP_724208|]
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uncharacterized protein Dmel_CG10165, isoform B [Drosophila melanogaster]

Protein Classification

Cyt_b561 domain-containing protein( domain architecture ID 10504994)

Cyt_b561 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 47-182 5.66e-32

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


:

Pssm-ID: 427188  Cd Length: 137  Bit Score: 113.47  E-value: 5.66e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585269    47 MHMFMTGTGFHVLIAQAMMSHSkvNPLTRWLSHRNKSRFHAILQIVGGSMVLLGSLGKFSSKE----VHFNTWHGRVGGA 122
Cdd:pfam03188   1 WHPVLMVIGFIFLMGEAILVYR--VNSTRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNlsgiPHFYSLHSWLGLL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24585269   123 ASFFCAASIVGGFVNYFQPKFALKVMPPSELrfRHNLFGLVTFSLGMGAIYLGY-YSKFFT 182
Cdd:pfam03188  79 TVILYALQWVGGFVTFLFPGLSKRIRPLLLP--LHVFFGLVIFVLAIVTALLGLlEKLIFQ 137
 
Name Accession Description Interval E-value
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 47-182 5.66e-32

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 113.47  E-value: 5.66e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585269    47 MHMFMTGTGFHVLIAQAMMSHSkvNPLTRWLSHRNKSRFHAILQIVGGSMVLLGSLGKFSSKE----VHFNTWHGRVGGA 122
Cdd:pfam03188   1 WHPVLMVIGFIFLMGEAILVYR--VNSTRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNlsgiPHFYSLHSWLGLL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24585269   123 ASFFCAASIVGGFVNYFQPKFALKVMPPSELrfRHNLFGLVTFSLGMGAIYLGY-YSKFFT 182
Cdd:pfam03188  79 TVILYALQWVGGFVTFLFPGLSKRIRPLLLP--LHVFFGLVIFVLAIVTALLGLlEKLIFQ 137
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 47-176 1.77e-24

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 93.84  E-value: 1.77e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585269     47 MHMFMTGTGFHVLIAQAMMSHSkvnPLTRWLSHRNKSRFHAILQIVGGSMVLLGSLGKFSSKE----VHFNTWHGRVGGA 122
Cdd:smart00665   1 LHPVLMILGFGFLMGEAILVAR---PLTRFLSKPTWFLLHVVLQILALVLGVIGLLAIFISHNesgiANFYSLHSWLGLA 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 24585269    123 ASFFCAASIVGGFVNYFQPKFALKvmPPSELRFRHNLFGLVTFSLGMGAIYLGY 176
Cdd:smart00665  78 AFVLAGLQWLSGFLRPLPPGLPSK--YRSYLNPYHRFVGLAAFILAIVTIFLGL 129
Cyt_b561 cd08554
Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory ...
 44-176 7.76e-23

Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory vesicle-specific electron transport proteins. They are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments. This is an exclusively eukaryotic family. Members of the prokaryotic cytochrome b561 family are not deemed homologous.


Pssm-ID: 176489  Cd Length: 131  Bit Score: 89.65  E-value: 7.76e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585269  44 DTAMHMFMTGTGFHVLIAQAMMSHSKVNPLTRWLSHRNKSRFHAILQIVGGSMVLLGSLGKFSSKEVHFNTWHGRVGGAA 123
Cdd:cd08554   1 EFNWHPLLMVIGFVFLMGEALLVYRVFRLLTKRALKLLHAILHLLAFVLGLVGLLAVFLFHNAGGIANLYSLHSWLGLAT 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 24585269 124 SFFCAASIVGGFVNYFQPKFALKvmPPSELRFRHNLFGLVTFSLGMGAIYLGY 176
Cdd:cd08554  81 VLLFLLQFLSGFVLFLLPLLRLS--YRSSLLPFHRFFGLAIFVLAIATILLGI 131
 
Name Accession Description Interval E-value
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 47-182 5.66e-32

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 113.47  E-value: 5.66e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585269    47 MHMFMTGTGFHVLIAQAMMSHSkvNPLTRWLSHRNKSRFHAILQIVGGSMVLLGSLGKFSSKE----VHFNTWHGRVGGA 122
Cdd:pfam03188   1 WHPVLMVIGFIFLMGEAILVYR--VNSTRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNlsgiPHFYSLHSWLGLL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24585269   123 ASFFCAASIVGGFVNYFQPKFALKVMPPSELrfRHNLFGLVTFSLGMGAIYLGY-YSKFFT 182
Cdd:pfam03188  79 TVILYALQWVGGFVTFLFPGLSKRIRPLLLP--LHVFFGLVIFVLAIVTALLGLlEKLIFQ 137
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 47-176 1.77e-24

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 93.84  E-value: 1.77e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585269     47 MHMFMTGTGFHVLIAQAMMSHSkvnPLTRWLSHRNKSRFHAILQIVGGSMVLLGSLGKFSSKE----VHFNTWHGRVGGA 122
Cdd:smart00665   1 LHPVLMILGFGFLMGEAILVAR---PLTRFLSKPTWFLLHVVLQILALVLGVIGLLAIFISHNesgiANFYSLHSWLGLA 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 24585269    123 ASFFCAASIVGGFVNYFQPKFALKvmPPSELRFRHNLFGLVTFSLGMGAIYLGY 176
Cdd:smart00665  78 AFVLAGLQWLSGFLRPLPPGLPSK--YRSYLNPYHRFVGLAAFILAIVTIFLGL 129
Cyt_b561 cd08554
Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory ...
 44-176 7.76e-23

Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory vesicle-specific electron transport proteins. They are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments. This is an exclusively eukaryotic family. Members of the prokaryotic cytochrome b561 family are not deemed homologous.


Pssm-ID: 176489  Cd Length: 131  Bit Score: 89.65  E-value: 7.76e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585269  44 DTAMHMFMTGTGFHVLIAQAMMSHSKVNPLTRWLSHRNKSRFHAILQIVGGSMVLLGSLGKFSSKEVHFNTWHGRVGGAA 123
Cdd:cd08554   1 EFNWHPLLMVIGFVFLMGEALLVYRVFRLLTKRALKLLHAILHLLAFVLGLVGLLAVFLFHNAGGIANLYSLHSWLGLAT 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 24585269 124 SFFCAASIVGGFVNYFQPKFALKvmPPSELRFRHNLFGLVTFSLGMGAIYLGY 176
Cdd:cd08554  81 VLLFLLQFLSGFVLFLLPLLRLS--YRSSLLPFHRFFGLAIFVLAIATILLGI 131
Cyt_b561_CYB561D2_like cd08761
Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found ...
 28-185 1.66e-17

Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human CYB561D2 gene product. CYB561D2 is a candidate tumor suppressor. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176491  Cd Length: 183  Bit Score: 76.94  E-value: 1.66e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585269  28 LVAVFFFILARSLEFKDTAM---HMFMTGTGFHVLIAQAMMSHSKVNPLTRwLSHRNKSRFHAILQIVGGSMVLLGSLGK 104
Cdd:cd08761   1 LVAVVFAAFLLYIARPGTSLfswHPLLMSLGFLLLMTEALLLLQPTSSLTK-LARKTKVRLHWILQLLALLCILAGLVAI 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585269 105 FSSKEV----HFNTWHGRVGGAASFFCAASIVGGFVNYFQPKFALKVMPPSELRFRHNLFGLVTFSLGMGAIYLGYYSKF 180
Cdd:cd08761  80 YYNKERngkpHFTSWHGILGLVTVILIVLQALGGLALLYPPGLRRGESKAKKLKKYHRLSGYVAYLLGLATLVLGLETRW 159


                ....*
gi 24585269 181 FTKYV 185
Cdd:cd08761 160 FSKNV 164
Cyt_b561_ACYB-1_like cd08766
Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as ...
 47-181 4.00e-03

Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as found in plants, similar to the Arabidopsis thaliana ACYB-1 gene product, a cytochrome b561 isoform localized to the tonoplast. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), and might be capable of trans-membrane electron transport from intracellular ascorbate to extracellular ferric chelates. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176496  Cd Length: 144  Bit Score: 36.52  E-value: 4.00e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585269  47 MHMFMTGTGFHVLIAQAMMSHSKVNpltrwLSHRNKSRFHAILQIVGGSMVLLGSLGKF----SSKEVHFNTWHGRVGGA 122
Cdd:cd08766  10 VHPVLMVIGFIFLAGEAILAYKTVP-----GSREVQKAVHLTLHLVALVLGIVGIYAAFkfhnEVGIPNLYSLHSWLGIG 84

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24585269 123 ASFFCAASIVGGFVNYFQPKFALKVMppSELRFRHNLFGLVTFSLGMGAIYLGYYSKFF 181
Cdd:cd08766  85 TISLFGLQWLFGFVTFWFPGASRNTR--AALLPWHVFLGLAIYYLAIATAETGLLEKLT 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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