NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|24586463|ref|NP_724637|]
View 

nucleoporin at 44A, isoform B [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
8-302 5.92e-26

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 107.30  E-value: 5.92e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586463   8 IADHKDVIHDVVF--DyyGRRMATCSSDQTVKIWD-EDGQgkwnVTSSWKAHSGSIWRVSWAHPefGQVVATCSFDRTAS 84
Cdd:COG2319 158 LTGHSGAVTSVAFspD--GKLLASGSDDGTVRLWDlATGK----LLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTVR 229

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586463  85 VWeevigekvsstNTPTRRWVRrtTLVDSRTSVTDVEFAPKylGLLLATASADGIIRIyeapdimnlsqwpvqheisnkl 164
Cdd:COG2319 230 LW-----------DLATGKLLR--TLTGHSGSVRSVAFSPD--GRLLASGSADGTVRL---------------------- 272

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586463 165 plsclsWNTSTYMVTQLLAAGSDE----AATPTGKVFLFAYSEN--------SRKCVKidTVNDITDPVTDVAFAPNaGR 232
Cdd:COG2319 273 ------WDLATGELLRTLTGHSGGvnsvAFSPDGKLLASGSDDGtvrlwdlaTGKLLR--TLTGHTGAVRSVAFSPD-GK 343

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24586463 233 TfhmLAVASKD--LYIVNLRGVTdatdiskldiQTIKFSEHNCPVWRVCWNMLATMLISTGDDGCVRLWRMN 302
Cdd:COG2319 344 T---LASGSDDgtVRLWDLATGE----------LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
8-302 5.92e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 107.30  E-value: 5.92e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586463   8 IADHKDVIHDVVF--DyyGRRMATCSSDQTVKIWD-EDGQgkwnVTSSWKAHSGSIWRVSWAHPefGQVVATCSFDRTAS 84
Cdd:COG2319 158 LTGHSGAVTSVAFspD--GKLLASGSDDGTVRLWDlATGK----LLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTVR 229

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586463  85 VWeevigekvsstNTPTRRWVRrtTLVDSRTSVTDVEFAPKylGLLLATASADGIIRIyeapdimnlsqwpvqheisnkl 164
Cdd:COG2319 230 LW-----------DLATGKLLR--TLTGHSGSVRSVAFSPD--GRLLASGSADGTVRL---------------------- 272

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586463 165 plsclsWNTSTYMVTQLLAAGSDE----AATPTGKVFLFAYSEN--------SRKCVKidTVNDITDPVTDVAFAPNaGR 232
Cdd:COG2319 273 ------WDLATGELLRTLTGHSGGvnsvAFSPDGKLLASGSDDGtvrlwdlaTGKLLR--TLTGHTGAVRSVAFSPD-GK 343

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24586463 233 TfhmLAVASKD--LYIVNLRGVTdatdiskldiQTIKFSEHNCPVWRVCWNMLATMLISTGDDGCVRLWRMN 302
Cdd:COG2319 344 T---LASGSDDgtVRLWDLATGE----------LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-300 1.17e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.95  E-value: 1.17e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586463  11 HKDVIHDVVFDYYGRRMATCSSDQTVKIWDEDGQgkwNVTSSWKAHSGSIWRVSWaHPEfGQVVATCSFDRTASVWEEVI 90
Cdd:cd00200  50 HTGPVRDVAASADGTYLASGSSDKTIRLWDLETG---ECVRTLTGHTSYVSSVAF-SPD-GRILSSSSRDKTIKVWDVET 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586463  91 GEKVSSTNTPTRrwvrrttlvdsrtSVTDVEFAPKylGLLLATASADGIIRIYeapdimNLSQWPVQHEIS-NKLPLSCL 169
Cdd:cd00200 125 GKCLTTLRGHTD-------------WVNSVAFSPD--GTFVASSSQDGTIKLW------DLRTGKCVATLTgHTGEVNSV 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586463 170 SWNTSTYmvtQLLAAGSDeaatptGKVFLfaYSENSRKCVKIDTVNdiTDPVTDVAFAPNAgrtfHMLAVASKD--LYIV 247
Cdd:cd00200 184 AFSPDGE---KLLSSSSD------GTIKL--WDLSTGKCLGTLRGH--ENGVNSVAFSPDG----YLLASGSEDgtIRVW 246

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 24586463 248 NLR-GVTDATdiskldiqtikFSEHNCPVWRVCWNMLATMLISTGDDGCVRLWR 300
Cdd:cd00200 247 DLRtGECVQT-----------LSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 7-40 3.04e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 3.04e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 24586463      7 IIADHKDVIHDVVFDYYGRRMATCSSDQTVKIWD 40
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
11-40 2.10e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.10e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 24586463    11 HKDVIHDVVFDYYGRRMATCSSDQTVKIWD 40
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
8-302 5.92e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 107.30  E-value: 5.92e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586463   8 IADHKDVIHDVVF--DyyGRRMATCSSDQTVKIWD-EDGQgkwnVTSSWKAHSGSIWRVSWAHPefGQVVATCSFDRTAS 84
Cdd:COG2319 158 LTGHSGAVTSVAFspD--GKLLASGSDDGTVRLWDlATGK----LLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTVR 229

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586463  85 VWeevigekvsstNTPTRRWVRrtTLVDSRTSVTDVEFAPKylGLLLATASADGIIRIyeapdimnlsqwpvqheisnkl 164
Cdd:COG2319 230 LW-----------DLATGKLLR--TLTGHSGSVRSVAFSPD--GRLLASGSADGTVRL---------------------- 272

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586463 165 plsclsWNTSTYMVTQLLAAGSDE----AATPTGKVFLFAYSEN--------SRKCVKidTVNDITDPVTDVAFAPNaGR 232
Cdd:COG2319 273 ------WDLATGELLRTLTGHSGGvnsvAFSPDGKLLASGSDDGtvrlwdlaTGKLLR--TLTGHTGAVRSVAFSPD-GK 343

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24586463 233 TfhmLAVASKD--LYIVNLRGVTdatdiskldiQTIKFSEHNCPVWRVCWNMLATMLISTGDDGCVRLWRMN 302
Cdd:COG2319 344 T---LASGSDDgtVRLWDLATGE----------LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-300 1.17e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.95  E-value: 1.17e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586463  11 HKDVIHDVVFDYYGRRMATCSSDQTVKIWDEDGQgkwNVTSSWKAHSGSIWRVSWaHPEfGQVVATCSFDRTASVWEEVI 90
Cdd:cd00200  50 HTGPVRDVAASADGTYLASGSSDKTIRLWDLETG---ECVRTLTGHTSYVSSVAF-SPD-GRILSSSSRDKTIKVWDVET 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586463  91 GEKVSSTNTPTRrwvrrttlvdsrtSVTDVEFAPKylGLLLATASADGIIRIYeapdimNLSQWPVQHEIS-NKLPLSCL 169
Cdd:cd00200 125 GKCLTTLRGHTD-------------WVNSVAFSPD--GTFVASSSQDGTIKLW------DLRTGKCVATLTgHTGEVNSV 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586463 170 SWNTSTYmvtQLLAAGSDeaatptGKVFLfaYSENSRKCVKIDTVNdiTDPVTDVAFAPNAgrtfHMLAVASKD--LYIV 247
Cdd:cd00200 184 AFSPDGE---KLLSSSSD------GTIKL--WDLSTGKCLGTLRGH--ENGVNSVAFSPDG----YLLASGSEDgtIRVW 246

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 24586463 248 NLR-GVTDATdiskldiqtikFSEHNCPVWRVCWNMLATMLISTGDDGCVRLWR 300
Cdd:cd00200 247 DLRtGECVQT-----------LSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
11-308 8.33e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.44  E-value: 8.33e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586463  11 HKDVIHDVVF--DyyGRRMATCSSDQTVKIWD-EDGQgkwnVTSSWKAHSGSIWRVSWAHPefGQVVATCSFDRTASVWe 87
Cdd:COG2319 119 HTGAVRSVAFspD--GKTLASGSADGTVRLWDlATGK----LLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLW- 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586463  88 evigekvsstNTPTRRWVRrtTLVDSRTSVTDVEFAPKylGLLLATASADGIIRIYeapdimNLSQWPVQHEIS-NKLPL 166
Cdd:COG2319 190 ----------DLATGKLLR--TLTGHTGAVRSVAFSPD--GKLLASGSADGTVRLW------DLATGKLLRTLTgHSGSV 249

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586463 167 SCLSWNTSTymvtQLLAAGSDEaatptGKVFLfaYSENSRKCVKidTVNDITDPVTDVAFAPNaGRTfhmLAVASKDlYI 246
Cdd:COG2319 250 RSVAFSPDG----RLLASGSAD-----GTVRL--WDLATGELLR--TLTGHSGGVNSVAFSPD-GKL---LASGSDD-GT 311

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24586463 247 VNLrgvtdatdiskLDIQTIK----FSEHNCPVWRVCWNMLATMLISTGDDGCVRLWRMNYNRQWR 308
Cdd:COG2319 312 VRL-----------WDLATGKllrtLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLR 366
WD40 COG2319
WD40 repeat [General function prediction only];
11-321 3.05e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.04  E-value: 3.05e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586463  11 HKDVIHDVVFDYYGRRMATCSSDQTVKIWDEDGQGkwnVTSSWKAHSGSIWRVSWaHPEfGQVVATCSFDRTASVWeevi 90
Cdd:COG2319  77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL---LLRTLTGHTGAVRSVAF-SPD-GKTLASGSADGTVRLW---- 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586463  91 gekvsstNTPTRRWVRrtTLVDSRTSVTDVEFAPKylGLLLATASADGIIRIYeapdimNLSQWPVQHEISN-KLPLSCL 169
Cdd:COG2319 148 -------DLATGKLLR--TLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLW------DLATGKLLRTLTGhTGAVRSV 210

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586463 170 SWNTStymvTQLLAAGSDEaatptGKVFLfaYSENSRKCVKidTVNDITDPVTDVAFAPNaGRTfhmLAVASKD--LYIV 247
Cdd:COG2319 211 AFSPD----GKLLASGSAD-----GTVRL--WDLATGKLLR--TLTGHSGSVRSVAFSPD-GRL---LASGSADgtVRLW 273

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24586463 248 NLRGvtdatdisKLDIQTikFSEHNCPVWRVCWNMLATMLISTGDDGCVRLWRMNynrQWRCAAVLKAEGSGPT 321
Cdd:COG2319 274 DLAT--------GELLRT--LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA---TGKLLRTLTGHTGAVR 334
WD40 COG2319
WD40 repeat [General function prediction only];
7-147 2.32e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.49  E-value: 2.32e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586463   7 IIADHKDVIHDVVFDYYGRRMATCSSDQTVKIWD-EDGQgkwnVTSSWKAHSGSIWRVSWaHPEfGQVVATCSFDRTASV 85
Cdd:COG2319 283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDlATGK----LLRTLTGHTGAVRSVAF-SPD-GKTLASGSDDGTVRL 356

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24586463  86 WeevigekvsstNTPTRRWVRrtTLVDSRTSVTDVEFAPKylGLLLATASADGIIRIYEAPD 147
Cdd:COG2319 357 W-----------DLATGELLR--TLTGHTGAVTSVAFSPD--GRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
9-300 1.58e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.01  E-value: 1.58e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586463   9 ADHKDVIHDVVFDYYGRRMATCSSDQTVKIWDEDGQGkwnVTSSWKAHSGSIWRVSWAHPefGQVVATCSFDRTASVWEe 88
Cdd:COG2319  33 LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGA---LLATLLGHTAAVLSVAFSPD--GRLLASASADGTVRLWD- 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586463  89 vigekvsstntpTRRWVRRTTLVDSRTSVTDVEFAPKylGLLLATASADGIIRIYeapdimNLSQWPVQHEIS-NKLPLS 167
Cdd:COG2319 107 ------------LATGLLLRTLTGHTGAVRSVAFSPD--GKTLASGSADGTVRLW------DLATGKLLRTLTgHSGAVT 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586463 168 CLSWNTStymvTQLLAAGSDEaatptGKVFLfaYSENSRKCVKidTVNDITDPVTDVAFAPNaGRTfhmLAVASKDLYIV 247
Cdd:COG2319 167 SVAFSPD----GKLLASGSDD-----GTVRL--WDLATGKLLR--TLTGHTGAVRSVAFSPD-GKL---LASGSADGTVR 229

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 24586463 248 nlrgVTDATdiSKLDIQTikFSEHNCPVWRVCWNMLATMLISTGDDGCVRLWR 300
Cdd:COG2319 230 ----LWDLA--TGKLLRT--LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 7-40 3.04e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 3.04e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 24586463      7 IIADHKDVIHDVVFDYYGRRMATCSSDQTVKIWD 40
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
11-40 2.10e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.10e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 24586463    11 HKDVIHDVVFDYYGRRMATCSSDQTVKIWD 40
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 268-299 3.69e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 3.69e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 24586463    268 FSEHNCPVWRVCWNMLATMLISTGDDGCVRLW 299
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 46-87 9.68e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 9.68e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 24586463     46 KWNVTSSWKAHSGSIWRVSWaHPEfGQVVATCSFDRTASVWE 87
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAF-SPD-GKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
267-299 3.11e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 3.11e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 24586463   267 KFSEHNCPVWRVCWNMLATMLISTGDDGCVRLW 299
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
47-87 9.39e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.47  E-value: 9.39e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 24586463    47 WNVTSSWKAHSGSIWRVSWaHPEfGQVVATCSFDRTASVWE 87
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAF-SPD-GKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH