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Conserved domains on  [gi|24639364|ref|NP_726818|]
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egghead, isoform B [Drosophila melanogaster]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 10614002)

glycosyltransferase family 2 protein catalyzes the transfer of saccharide moieties from a donor to an acceptor to form glycosidic bonds

CATH:  3.90.550.10
CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  10521532|12691742|9445404|12200473|10508766
SCOP:  3000077

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_trans_2_3 pfam13632
Glycosyl transferase family group 2; Members of this family of prokaryotic proteins include ...
 184-372 2.31e-42

Glycosyl transferase family group 2; Members of this family of prokaryotic proteins include putative glucosyltransferases, which are involved in bacterial capsule biosynthesis.


:

Pssm-ID: 433365 [Multi-domain]  Cd Length: 192  Bit Score: 148.25  E-value: 2.31e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639364   184 WIVHLDEETLLTENSVRGIINFVLDGKHPFGQGLITYAneNVVNWLTTLADSFRvSDDMGKLRLQFKLFHKPLFSWkGSY 263
Cdd:pfam13632   1 WILLLDADTVLPPDCLLGIANEMASPEVAIIQGPILPM--NVGNYLEELAALFF-ADDHGKSIPVRMALGRVLPFV-GSG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639364   264 VVTQVSAERSVSFDNgiDGSVAEDCFFAMRAFSQGYTFNFIEGE-MYEKSPFTLLDFLQQRKRWLQGILLVVHSKMIPFK 342
Cdd:pfam13632  77 AFLRRSALQEVGGWD--DGSVSEDFDFGLRLQRAGYRVRFAPYSaVYEKSPLTFRDFLRQRRRWAYGCLLILLIRLLGYL 154

                         170       180       190
                  ....*....|....*....|....*....|.
gi 24639364   343 HKLLLGISVYSWVTMPL-STSNIIFAALYPI 372
Cdd:pfam13632 155 GTLLWSGLPLALLLLLLfSISSLALVLLLLA 185
 
Name Accession Description Interval E-value
Glyco_trans_2_3 pfam13632
Glycosyl transferase family group 2; Members of this family of prokaryotic proteins include ...
 184-372 2.31e-42

Glycosyl transferase family group 2; Members of this family of prokaryotic proteins include putative glucosyltransferases, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433365 [Multi-domain]  Cd Length: 192  Bit Score: 148.25  E-value: 2.31e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639364   184 WIVHLDEETLLTENSVRGIINFVLDGKHPFGQGLITYAneNVVNWLTTLADSFRvSDDMGKLRLQFKLFHKPLFSWkGSY 263
Cdd:pfam13632   1 WILLLDADTVLPPDCLLGIANEMASPEVAIIQGPILPM--NVGNYLEELAALFF-ADDHGKSIPVRMALGRVLPFV-GSG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639364   264 VVTQVSAERSVSFDNgiDGSVAEDCFFAMRAFSQGYTFNFIEGE-MYEKSPFTLLDFLQQRKRWLQGILLVVHSKMIPFK 342
Cdd:pfam13632  77 AFLRRSALQEVGGWD--DGSVSEDFDFGLRLQRAGYRVRFAPYSaVYEKSPLTFRDFLRQRRRWAYGCLLILLIRLLGYL 154

                         170       180       190
                  ....*....|....*....|....*....|.
gi 24639364   343 HKLLLGISVYSWVTMPL-STSNIIFAALYPI 372
Cdd:pfam13632 155 GTLLWSGLPLALLLLLLfSISSLALVLLLLA 185
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 281-411 2.82e-08

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 55.13  E-value: 2.82e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639364 281 DGSVAEDCFFAMRAFSQGYTFNFIEG-EMYEKSPFTLLDFLQQRKRWLQGIL--LVVHSKMIPFKHKLLLGISVYSWVTM 357
Cdd:COG1215 163 EDTLGEDLDLSLRLLRAGYRIVYVPDaVVYEEAPETLRALFRQRRRWARGGLqlLLKHRPLLRPRRLLLFLLLLLLPLLL 242

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 24639364 358 PLSTSNIIFAALYPIPCP--NLVDFVCAFIAAINIYMYVFGVIKSFSLYRFGLFRF 411
Cdd:COG1215 243 LLLLLALLALLLLLLPALllALLLALRRRRLLLPLLHLLYGLLLLLAALRGKKVVW 298
CESA_like_2 cd06427
CESA_like_2 is a member of the cellulose synthase superfamily; The cellulose synthase (CESA) ...
 283-337 1.99e-04

CESA_like_2 is a member of the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, Glucan Biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of glucan.


Pssm-ID: 133049 [Multi-domain]  Cd Length: 241  Bit Score: 42.63  E-value: 1.99e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 24639364 283 SVAEDCFFAMRAFSQGYTFNFIEGEMYEKSPFTLLDFLQQRKRWLQGIL--LVVHSK 337
Cdd:cd06427 183 NVTEDADLGLRLARAGYRTGVLNSTTLEEANNALGNWIRQRSRWIKGYMqtWLVHMR 239
PRK05454 PRK05454
glucans biosynthesis glucosyltransferase MdoH;
309-359 8.75e-03

glucans biosynthesis glucosyltransferase MdoH;


Pssm-ID: 235476 [Multi-domain]  Cd Length: 605  Bit Score: 38.32  E-value: 8.75e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 24639364  309 YEKSPFTLLDFLQQRKRWLQGILLvvHSKMIPFK-----HKLLLGISVYSWVTMPL 359
Cdd:PRK05454 355 YEELPPNLLDELKRDRRWCQGNLQ--HLRLLLAKglhpvSRLHFLTGIMSYLSAPL 408
 
Name Accession Description Interval E-value
Glyco_trans_2_3 pfam13632
Glycosyl transferase family group 2; Members of this family of prokaryotic proteins include ...
 184-372 2.31e-42

Glycosyl transferase family group 2; Members of this family of prokaryotic proteins include putative glucosyltransferases, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433365 [Multi-domain]  Cd Length: 192  Bit Score: 148.25  E-value: 2.31e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639364   184 WIVHLDEETLLTENSVRGIINFVLDGKHPFGQGLITYAneNVVNWLTTLADSFRvSDDMGKLRLQFKLFHKPLFSWkGSY 263
Cdd:pfam13632   1 WILLLDADTVLPPDCLLGIANEMASPEVAIIQGPILPM--NVGNYLEELAALFF-ADDHGKSIPVRMALGRVLPFV-GSG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639364   264 VVTQVSAERSVSFDNgiDGSVAEDCFFAMRAFSQGYTFNFIEGE-MYEKSPFTLLDFLQQRKRWLQGILLVVHSKMIPFK 342
Cdd:pfam13632  77 AFLRRSALQEVGGWD--DGSVSEDFDFGLRLQRAGYRVRFAPYSaVYEKSPLTFRDFLRQRRRWAYGCLLILLIRLLGYL 154

                         170       180       190
                  ....*....|....*....|....*....|.
gi 24639364   343 HKLLLGISVYSWVTMPL-STSNIIFAALYPI 372
Cdd:pfam13632 155 GTLLWSGLPLALLLLLLfSISSLALVLLLLA 185
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 281-411 2.82e-08

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 55.13  E-value: 2.82e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639364 281 DGSVAEDCFFAMRAFSQGYTFNFIEG-EMYEKSPFTLLDFLQQRKRWLQGIL--LVVHSKMIPFKHKLLLGISVYSWVTM 357
Cdd:COG1215 163 EDTLGEDLDLSLRLLRAGYRIVYVPDaVVYEEAPETLRALFRQRRRWARGGLqlLLKHRPLLRPRRLLLFLLLLLLPLLL 242

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 24639364 358 PLSTSNIIFAALYPIPCP--NLVDFVCAFIAAINIYMYVFGVIKSFSLYRFGLFRF 411
Cdd:COG1215 243 LLLLLALLALLLLLLPALllALLLALRRRRLLLPLLHLLYGLLLLLAALRGKKVVW 298
CESA_like_2 cd06427
CESA_like_2 is a member of the cellulose synthase superfamily; The cellulose synthase (CESA) ...
 283-337 1.99e-04

CESA_like_2 is a member of the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, Glucan Biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of glucan.


Pssm-ID: 133049 [Multi-domain]  Cd Length: 241  Bit Score: 42.63  E-value: 1.99e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 24639364 283 SVAEDCFFAMRAFSQGYTFNFIEGEMYEKSPFTLLDFLQQRKRWLQGIL--LVVHSK 337
Cdd:cd06427 183 NVTEDADLGLRLARAGYRTGVLNSTTLEEANNALGNWIRQRSRWIKGYMqtWLVHMR 239
PRK05454 PRK05454
glucans biosynthesis glucosyltransferase MdoH;
309-359 8.75e-03

glucans biosynthesis glucosyltransferase MdoH;


Pssm-ID: 235476 [Multi-domain]  Cd Length: 605  Bit Score: 38.32  E-value: 8.75e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 24639364  309 YEKSPFTLLDFLQQRKRWLQGILLvvHSKMIPFK-----HKLLLGISVYSWVTMPL 359
Cdd:PRK05454 355 YEELPPNLLDELKRDRRWCQGNLQ--HLRLLLAKglhpvSRLHFLTGIMSYLSAPL 408
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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