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Conserved domains on  [gi|442617342|ref|NP_730819|]
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uncharacterized protein Dmel_CG1090, isoform H [Drosophila melanogaster]

Protein Classification

putative sodium/potassium/calcium exchanger( domain architecture ID 1001229)

putative sodium/potassium/calcium exchanger

Gene Ontology:  GO:0005886|GO:0015293|GO:0006811
PubMed:  15163769
TCDB:  2.A.19

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 75-617 2.61e-89

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 299.99  E-value: 2.61e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342    75 TPIHGAVPTWRPkrdNCTPPAieQFPQPLMNKWARQHGGLILHILVAVFTFFGLAIVCDEYFVASLDRLCEELKLSPDVA 154
Cdd:TIGR00927  423 SPSPSALPPGQP---DLHPKA--EYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVA 497

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342   155 GATFMAAGSSAPELATVVIGVFFAKDDIGISGVIGSAVFNIMFVISVCALCSGTVCQLNWWPLVRDCFFYCVSiLVMLII 234
Cdd:TIGR00927  498 GATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILD-LMMLIL 576

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342   235 IFND-VISCFESVVMLLCYVGYCVALHFNTELERW--------------ALG---------LNLPFKLPSKEEQSALVTY 290
Cdd:TIGR00927  577 FFLDsLIAWWESLLLLLAYALYVFTMKWNKQIELWvkeqlsrrpvakvmALGdlskgdvaeAEHTGERTGEEGERPTEAE 656

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342   291 KNVPEGSYTQ-------------ESVGQTQGQKATD-----DSETRSAKPQSDYQDYSDPNPTWDPNAAWGDESQPNPVA 352
Cdd:TIGR00927  657 GENGEESGGEaeqegetetkgenESEGEIPAERKGEqegegEIEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIETGE 736

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342   353 NPPPVDDWGMGHS---------GQENMGYHADQPESVVTGDGPPAAVKSG------------GQVVSTQATSAGGNDYYK 411
Cdd:TIGR00927  737 EGEEVEDEGEGEAegkheveteGDRKETEHEGETEAEGKEDEDEGEIQAGedgemkgdegaeGKVEHEGETEAGEKDEHE 816

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342   412 ---------------------STDKQREPRRDPLLRPMEGG----------------------------------LPALV 436
Cdd:TIGR00927  817 gqsetqaddtevkdetgeqelNAENQGEAKQDEKGVDGGGGsdggdseeeeeeeeeeeeeeeeeeeeeeeeeeneEPLSL 896

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342   437 SW------YVVY----PIHFLCKKTMPDCRQEQYRNWYPFTFLMSMVWISFYSYFMVWMITVIGSTLAIPDTVMGLTFVA 506
Cdd:TIGR00927  897 EWpetrqkQAIYlfllPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILA 976

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342   507 AGVSVPDALSSIAVIKEGFGDMAVSNAIGSNVFDILVCLGLPWFIQTAI--IKPgshVNVISKGLAYSTLSLFSTVVFLI 584
Cdd:TIGR00927  977 AGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLIngLQP---VPVSSNGLFCAIVLLFLMLLFVI 1053

                          650       660       670
                   ....*....|....*....|....*....|...
gi 442617342   585 LSTHLNGWKLDKRLGIILMVWYLFFITLASLYE 617
Cdd:TIGR00927 1054 SSIASCKWRMNKILGFTMFLLYFVFLIISVMLE 1086
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 75-617 2.61e-89

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 299.99  E-value: 2.61e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342    75 TPIHGAVPTWRPkrdNCTPPAieQFPQPLMNKWARQHGGLILHILVAVFTFFGLAIVCDEYFVASLDRLCEELKLSPDVA 154
Cdd:TIGR00927  423 SPSPSALPPGQP---DLHPKA--EYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVA 497

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342   155 GATFMAAGSSAPELATVVIGVFFAKDDIGISGVIGSAVFNIMFVISVCALCSGTVCQLNWWPLVRDCFFYCVSiLVMLII 234
Cdd:TIGR00927  498 GATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILD-LMMLIL 576

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342   235 IFND-VISCFESVVMLLCYVGYCVALHFNTELERW--------------ALG---------LNLPFKLPSKEEQSALVTY 290
Cdd:TIGR00927  577 FFLDsLIAWWESLLLLLAYALYVFTMKWNKQIELWvkeqlsrrpvakvmALGdlskgdvaeAEHTGERTGEEGERPTEAE 656

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342   291 KNVPEGSYTQ-------------ESVGQTQGQKATD-----DSETRSAKPQSDYQDYSDPNPTWDPNAAWGDESQPNPVA 352
Cdd:TIGR00927  657 GENGEESGGEaeqegetetkgenESEGEIPAERKGEqegegEIEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIETGE 736

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342   353 NPPPVDDWGMGHS---------GQENMGYHADQPESVVTGDGPPAAVKSG------------GQVVSTQATSAGGNDYYK 411
Cdd:TIGR00927  737 EGEEVEDEGEGEAegkheveteGDRKETEHEGETEAEGKEDEDEGEIQAGedgemkgdegaeGKVEHEGETEAGEKDEHE 816

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342   412 ---------------------STDKQREPRRDPLLRPMEGG----------------------------------LPALV 436
Cdd:TIGR00927  817 gqsetqaddtevkdetgeqelNAENQGEAKQDEKGVDGGGGsdggdseeeeeeeeeeeeeeeeeeeeeeeeeeneEPLSL 896

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342   437 SW------YVVY----PIHFLCKKTMPDCRQEQYRNWYPFTFLMSMVWISFYSYFMVWMITVIGSTLAIPDTVMGLTFVA 506
Cdd:TIGR00927  897 EWpetrqkQAIYlfllPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILA 976

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342   507 AGVSVPDALSSIAVIKEGFGDMAVSNAIGSNVFDILVCLGLPWFIQTAI--IKPgshVNVISKGLAYSTLSLFSTVVFLI 584
Cdd:TIGR00927  977 AGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLIngLQP---VPVSSNGLFCAIVLLFLMLLFVI 1053

                          650       660       670
                   ....*....|....*....|....*....|...
gi 442617342   585 LSTHLNGWKLDKRLGIILMVWYLFFITLASLYE 617
Cdd:TIGR00927 1054 SSIASCKWRMNKILGFTMFLLYFVFLIISVMLE 1086
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
134-612 4.24e-33

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 128.71  E-value: 4.24e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342 134 EYFVASLDRLCEELKLSPDVAGATFMAAGSSAPELATVVIGVFFAKDDIGISGVIGSAVFNIMFVISVCALCSGTVCQLN 213
Cdd:COG0530    2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRPLAVDRR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342 214 WwpLVRDCFFYCVSILVMLIIIFNDVISCFESVVMLLCYVGYCVALhfntelerwalglnlpfklpskeeqsalvtyknv 293
Cdd:COG0530   82 V--LRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL---------------------------------- 125

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342 294 pegsytqesvgqtqgqkatddseTRSAKPQSDYQDYSDPNPTWDPNAAWgdesqpnpvanpppvddwgmghsgqenmgyh 373
Cdd:COG0530  126 -----------------------IRRARKEPAWEEVEEELEEKPKMSLW------------------------------- 151

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342 374 adqpesvvtgdgppaavKSGGQVVstqatsaggndyykstdkqreprrdpllrpmeGGLPALVswyvvypihflckktmp 453
Cdd:COG0530  152 -----------------KALLLLV--------------------------------LGLALLV----------------- 165

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342 454 dcrqeqyrnwypftflmsmvwisFYSYFMVWMITVIGSTLAIPDTVMGLTFVAAGVSVPDALSSIAVIKEGFGDMAVSNA 533
Cdd:COG0530  166 -----------------------VGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNI 222

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442617342 534 IGSNVFDILVCLGLPwfiqtAIIKPGShVNVISKGLAYSTLsLFSTVVFLILSthLNGWKLDKRLGIILMVWYLFFITL 612
Cdd:COG0530  223 IGSNIFNILLVLGIG-----ALITPIP-VDPAVLSFDLPVM-LAATLLLLGLL--RTGGRIGRWEGLLLLALYLAYLAL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 463-615 2.68e-30

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 116.16  E-value: 2.68e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342  463 WYPFTFLMSMVWISFYSYFMVWMITVIGSTLAIPDTVMGLTFVAAGVSVPDALSSIAVIKEGFGDMAVSNAIGSNVFDIL 542
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442617342  543 VCLGLPWFIQTAIIKPGSHVNVISKGLAYSTLSLFSTVVFLIlsthLNGWKLDKRLGIILMVWYLFFITLASL 615
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLLKLDLGVLLLVALLLLLLLLLLLL----PLFGRLSRFEGLVLLLLYIVYLVFQIV 149
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 119-612 1.20e-12

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 70.95  E-value: 1.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342 119 LVAVFTFFGLAIVcdEYFVASLDRLCEELKLSPDVAGATFMAAGSSAPELATvVIGVFFAKD--DIGISGVIGSAVFNIM 196
Cdd:PLN03151 147 LVALFYLLGNTAA--DYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFA-SIAAFVGKDagEVGLNSVLGGAVFVTC 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342 197 FVISVCALC-SGTVCQLNWWPLVRDCFFYCVSILVMLIIIFNDVISCFESVVMLLCYVGYCVALHFNTELERWALGLNLP 275
Cdd:PLN03151 224 VVVGIVSLCvADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAANEILRKHARRLKLD 303

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342 276 FKLPskeeqsaLVTYKnvpeGSYTQESVGQTQGQKAT-DDSETRSAKPQ-----------SDYQDYS----------DPN 333
Cdd:PLN03151 304 VVTP-------LLPVQ----GSIFSPSVEEDESMYSPlLESDTESDVPRlqtslpqwmwaSNVAIYSnhfakgsvhdEER 372

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342 334 PTWdpnaAWGDESQPNPVANPPPV-----------------------DDWGMGHSgqenMGYHADQPESVV----TGDGP 386
Cdd:PLN03151 373 PPW----GWTDEGAEVESSLFSCSklfsllempltiprrltipiveeDRWSKTYA----VASASLAPVLLAflwsSQDDV 444

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342 387 PAAVKSGGQVVSTQATSAGGNDYYKSTDKQREPRRdpllrpmegglpalvswyvvypihFLckktMPdcrqeqyrnWYPF 466
Cdd:PLN03151 445 SLQARIAAYFIGVAIGSTLGFLAYKYTEPDRPPRR------------------------FL----IP---------WVLG 487

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342 467 TFLMSMVWISFYSYFMVWMITVIGSTLAIPDTVMGLTFVAAGVSVPDALSSIAVIKEGfGD---MAVSNAIGSNVFDILV 543
Cdd:PLN03151 488 GFIMSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNG-GDgvqIAMSGCYAGPMFNTLV 566

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442617342 544 CLGLPWFIQTAIIKPGSHVNVISKGLAYSTLSLFSTVVFLILSTHLNGWKLDKRLGIILMVWYLFFITL 612
Cdd:PLN03151 567 GLGMSMLLGAWSKSPESYMLPEDSSLFYTMGFLVSGLIWALVVLPRNDMRPNKTLGVGLIALYLIFLTF 635
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 75-617 2.61e-89

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 299.99  E-value: 2.61e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342    75 TPIHGAVPTWRPkrdNCTPPAieQFPQPLMNKWARQHGGLILHILVAVFTFFGLAIVCDEYFVASLDRLCEELKLSPDVA 154
Cdd:TIGR00927  423 SPSPSALPPGQP---DLHPKA--EYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVA 497

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342   155 GATFMAAGSSAPELATVVIGVFFAKDDIGISGVIGSAVFNIMFVISVCALCSGTVCQLNWWPLVRDCFFYCVSiLVMLII 234
Cdd:TIGR00927  498 GATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILD-LMMLIL 576

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342   235 IFND-VISCFESVVMLLCYVGYCVALHFNTELERW--------------ALG---------LNLPFKLPSKEEQSALVTY 290
Cdd:TIGR00927  577 FFLDsLIAWWESLLLLLAYALYVFTMKWNKQIELWvkeqlsrrpvakvmALGdlskgdvaeAEHTGERTGEEGERPTEAE 656

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342   291 KNVPEGSYTQ-------------ESVGQTQGQKATD-----DSETRSAKPQSDYQDYSDPNPTWDPNAAWGDESQPNPVA 352
Cdd:TIGR00927  657 GENGEESGGEaeqegetetkgenESEGEIPAERKGEqegegEIEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIETGE 736

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342   353 NPPPVDDWGMGHS---------GQENMGYHADQPESVVTGDGPPAAVKSG------------GQVVSTQATSAGGNDYYK 411
Cdd:TIGR00927  737 EGEEVEDEGEGEAegkheveteGDRKETEHEGETEAEGKEDEDEGEIQAGedgemkgdegaeGKVEHEGETEAGEKDEHE 816

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342   412 ---------------------STDKQREPRRDPLLRPMEGG----------------------------------LPALV 436
Cdd:TIGR00927  817 gqsetqaddtevkdetgeqelNAENQGEAKQDEKGVDGGGGsdggdseeeeeeeeeeeeeeeeeeeeeeeeeeneEPLSL 896

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342   437 SW------YVVY----PIHFLCKKTMPDCRQEQYRNWYPFTFLMSMVWISFYSYFMVWMITVIGSTLAIPDTVMGLTFVA 506
Cdd:TIGR00927  897 EWpetrqkQAIYlfllPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILA 976

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342   507 AGVSVPDALSSIAVIKEGFGDMAVSNAIGSNVFDILVCLGLPWFIQTAI--IKPgshVNVISKGLAYSTLSLFSTVVFLI 584
Cdd:TIGR00927  977 AGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLIngLQP---VPVSSNGLFCAIVLLFLMLLFVI 1053

                          650       660       670
                   ....*....|....*....|....*....|...
gi 442617342   585 LSTHLNGWKLDKRLGIILMVWYLFFITLASLYE 617
Cdd:TIGR00927 1054 SSIASCKWRMNKILGFTMFLLYFVFLIISVMLE 1086
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 116-609 1.65e-40

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 149.78  E-value: 1.65e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342  116 LHILVAVFTFFGLAIVCDEYFVASLDRLCEELKLSPDVAGATFMAAGSSAPELATVVIGVFFAKDDIGISGVIGSAVFNI 195
Cdd:TIGR00367   1 LLLIGYLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342  196 MFVISVCALCSGTVcqLNWWPLVRDCFFYCVSILVMLIIIFNDVISCFESVVMLLCYVGYcvaLHFNTELERWalglnlp 275
Cdd:TIGR00367  81 LLILGLSAIFSPII--VDKDWLRRDILFYLLVSILLLFFGLDGQISRIDGVVLLILYIVY---LLFLVKNERW------- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342  276 fklpskeeqsalvtyknVPEGSYTQESVGQTqgqkatddsetrsakpqsdyqdysdpnptwdpnaawgdesqpnpvanpp 355
Cdd:TIGR00367 149 -----------------VKYDTYTEENLDEN------------------------------------------------- 162

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342  356 pvddwgmghsgqenmgyhadqpesvvtgdgppaavksggqvvstqatsaggndyykstdkqreprrdpllrPMEGGLPAL 435
Cdd:TIGR00367 163 -----------------------------------------------------------------------NRRPQIFFS 171

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342  436 VSWYVVypihflckktmpdcrqeqyrnwypftflmSMVWISFYSYFMVWMITVIGSTLAIPDTVMGLTFVAAGVSVPDAL 515
Cdd:TIGR00367 172 LVLLII-----------------------------GLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELV 222

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342  516 SSIAVIKEGFGDMAVSNAIGSNVFDILVCLGLPWFIQTAIIKPGSHVnviskgLAYSTLSLFSTVVFLILSThlnGWKLD 595
Cdd:TIGR00367 223 VSLAAARKGLGDIAVGNVIGSNIFNILVGLGVPSLFMPIPVEPLAYN------LDAPVMVIVTLLLMLFFKT---SMKLG 293

                         490
                  ....*....|....
gi 442617342  596 KRLGIILMVWYLFF 609
Cdd:TIGR00367 294 RWEGILLLALYIAY 307
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
134-612 4.24e-33

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 128.71  E-value: 4.24e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342 134 EYFVASLDRLCEELKLSPDVAGATFMAAGSSAPELATVVIGVFFAKDDIGISGVIGSAVFNIMFVISVCALCSGTVCQLN 213
Cdd:COG0530    2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRPLAVDRR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342 214 WwpLVRDCFFYCVSILVMLIIIFNDVISCFESVVMLLCYVGYCVALhfntelerwalglnlpfklpskeeqsalvtyknv 293
Cdd:COG0530   82 V--LRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL---------------------------------- 125

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342 294 pegsytqesvgqtqgqkatddseTRSAKPQSDYQDYSDPNPTWDPNAAWgdesqpnpvanpppvddwgmghsgqenmgyh 373
Cdd:COG0530  126 -----------------------IRRARKEPAWEEVEEELEEKPKMSLW------------------------------- 151

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342 374 adqpesvvtgdgppaavKSGGQVVstqatsaggndyykstdkqreprrdpllrpmeGGLPALVswyvvypihflckktmp 453
Cdd:COG0530  152 -----------------KALLLLV--------------------------------LGLALLV----------------- 165

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342 454 dcrqeqyrnwypftflmsmvwisFYSYFMVWMITVIGSTLAIPDTVMGLTFVAAGVSVPDALSSIAVIKEGFGDMAVSNA 533
Cdd:COG0530  166 -----------------------VGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNI 222

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442617342 534 IGSNVFDILVCLGLPwfiqtAIIKPGShVNVISKGLAYSTLsLFSTVVFLILSthLNGWKLDKRLGIILMVWYLFFITL 612
Cdd:COG0530  223 IGSNIFNILLVLGIG-----ALITPIP-VDPAVLSFDLPVM-LAATLLLLGLL--RTGGRIGRWEGLLLLALYLAYLAL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 463-615 2.68e-30

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 116.16  E-value: 2.68e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342  463 WYPFTFLMSMVWISFYSYFMVWMITVIGSTLAIPDTVMGLTFVAAGVSVPDALSSIAVIKEGFGDMAVSNAIGSNVFDIL 542
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442617342  543 VCLGLPWFIQTAIIKPGSHVNVISKGLAYSTLSLFSTVVFLIlsthLNGWKLDKRLGIILMVWYLFFITLASL 615
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLLKLDLGVLLLVALLLLLLLLLLLL----PLFGRLSRFEGLVLLLLYIVYLVFQIV 149
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 117-259 7.20e-22

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 92.28  E-value: 7.20e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342  117 HILVAVFTFFGLAIVCDEYFVASLDRLCEELKLSPDVAGATFMAAGSSAPELATVVIGVFFAKDDIGISGVIGSAVFNIM 196
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442617342  197 FVISVCALCSGTVCQLNWWPLVRDCFFY----CVSILVMLIIIFNDVISCFESVVMLLCYVGYCVAL 259
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLLKLDLGVLLLvallLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQ 147
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
120-259 3.36e-17

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 82.49  E-value: 3.36e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342 120 VAVFTFFGLA--IVCDEYFVASLDRLCEELKLSPDVAGATFMAAGSSAPELATVVIGVFFAKDDIGISGVIGSAVFNIMF 197
Cdd:COG0530  153 ALLLLVLGLAllVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILL 232

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442617342 198 VISVCALcsgtvcqLNWWP-----LVRDCFFYCVSILVMLIIIFND-VISCFESVVMLLCYVGYCVAL 259
Cdd:COG0530  233 VLGIGAL-------ITPIPvdpavLSFDLPVMLAATLLLLGLLRTGgRIGRWEGLLLLALYLAYLALL 293
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 119-612 1.20e-12

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 70.95  E-value: 1.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342 119 LVAVFTFFGLAIVcdEYFVASLDRLCEELKLSPDVAGATFMAAGSSAPELATvVIGVFFAKD--DIGISGVIGSAVFNIM 196
Cdd:PLN03151 147 LVALFYLLGNTAA--DYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFA-SIAAFVGKDagEVGLNSVLGGAVFVTC 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342 197 FVISVCALC-SGTVCQLNWWPLVRDCFFYCVSILVMLIIIFNDVISCFESVVMLLCYVGYCVALHFNTELERWALGLNLP 275
Cdd:PLN03151 224 VVVGIVSLCvADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAANEILRKHARRLKLD 303

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342 276 FKLPskeeqsaLVTYKnvpeGSYTQESVGQTQGQKAT-DDSETRSAKPQ-----------SDYQDYS----------DPN 333
Cdd:PLN03151 304 VVTP-------LLPVQ----GSIFSPSVEEDESMYSPlLESDTESDVPRlqtslpqwmwaSNVAIYSnhfakgsvhdEER 372

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342 334 PTWdpnaAWGDESQPNPVANPPPV-----------------------DDWGMGHSgqenMGYHADQPESVV----TGDGP 386
Cdd:PLN03151 373 PPW----GWTDEGAEVESSLFSCSklfsllempltiprrltipiveeDRWSKTYA----VASASLAPVLLAflwsSQDDV 444

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342 387 PAAVKSGGQVVSTQATSAGGNDYYKSTDKQREPRRdpllrpmegglpalvswyvvypihFLckktMPdcrqeqyrnWYPF 466
Cdd:PLN03151 445 SLQARIAAYFIGVAIGSTLGFLAYKYTEPDRPPRR------------------------FL----IP---------WVLG 487

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342 467 TFLMSMVWISFYSYFMVWMITVIGSTLAIPDTVMGLTFVAAGVSVPDALSSIAVIKEGfGD---MAVSNAIGSNVFDILV 543
Cdd:PLN03151 488 GFIMSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNG-GDgvqIAMSGCYAGPMFNTLV 566

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442617342 544 CLGLPWFIQTAIIKPGSHVNVISKGLAYSTLSLFSTVVFLILSTHLNGWKLDKRLGIILMVWYLFFITL 612
Cdd:PLN03151 567 GLGMSMLLGAWSKSPESYMLPEDSSLFYTMGFLVSGLIWALVVLPRNDMRPNKTLGVGLIALYLIFLTF 635
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 466-618 1.61e-12

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 68.89  E-value: 1.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342  466 FTFLMSMVWISFYSYFMVWMITVIGSTLAIPDTVMGLTFVAAGVSVPDALSSIAVIKEGFGDMAVSNAIGSNVFDILVCL 545
Cdd:TIGR00367   5 GYLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLIL 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442617342  546 GLpwfiqTAIIKPgshVNVISKGLAYSTLSLFSTVVFLILSTHLNGWklDKRLGIILM----VWYLFFITLASLYEL 618
Cdd:TIGR00367  85 GL-----SAIFSP---IIVDKDWLRRDILFYLLVSILLLFFGLDGQI--SRIDGVVLLilyiVYLLFLVKNERWVKY 151
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 487-560 1.79e-12

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 68.90  E-value: 1.79e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442617342 487 TVIGSTLAIPDTVMGLTFVAAGVSVPDALSSIAVIKEGFGDMAVSNAIGSNVFDILVCLGLPwfiqtAIIKPGS 560
Cdd:PRK10734 198 TVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLP-----ALISPGE 266
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 482-617 3.90e-11

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 64.67  E-value: 3.90e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342 482 MVWMITVIGSTLAIPDTVMGLTFVAAGVSVPDALSSIAVIKEGFGDMAVSNAIGSNVFDILVCLGLpwfiqTAIIKPGS- 560
Cdd:PRK10734  22 LVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLILGL-----AALIRPFTv 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442617342 561 HVNVISKGLAystLSLFSTVV--FLILSTHLNgwKLDkrlGIILM----VWYLFFITLASLYE 617
Cdd:PRK10734  97 HSDVLRRELP---LMLLVSVLagSVLYDGQLS--RSD---GIFLLllavLWLLFIVKIARLAE 151
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 474-621 1.43e-10

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 64.43  E-value: 1.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342  474 WISF-YSYFMVWMITVI--------GSTLAIPDTVMGLTFVAAGVSVPDALSS-IAVIKEGFGDMAVSNAIGSNVFDILV 543
Cdd:TIGR00845 756 WACFvVSILMIGVLTAFigdlashfGCTIGLKDSVTAVVFVALGTSVPDTFASkVAATQDQYADASIGNVTGSNAVNVFL 835

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342  544 CLGLPWFIqTAIIKP--GSHVNVISKGLAYS----TLSLFSTVVFLILSTH------LNGWKLDK--RLGIILMVW--YL 607
Cdd:TIGR00845 836 GIGVAWSI-AAIYHAanGTQFKVSPGTLAFSvtlfTIFAFICIGVLLYRRRpeiggeLGGPRTAKllTSALFVLLWllYI 914

                         170
                  ....*....|....
gi 442617342  608 FFITLASLYELNVF 621
Cdd:TIGR00845 915 LFSSLEAYCHIKGF 928
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 110-255 3.15e-10

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 61.57  E-value: 3.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342  110 QHGGLILHILVAVFTFFGLAIVCdEYFVASLDRLCEELKLSPDVAGATFMAAGSSAPELATVVIGVFFAKDDIGISGVIG 189
Cdd:TIGR00367 164 RRPQIFFSLVLLIIGLIGLVVGS-RLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIG 242

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342  190 SAVFNIMFVISVCALCS-GTVCQLNwwpLVRD---CFFycVSILVMLIIIFNDVISCFESVVMLLCYVGY 255
Cdd:TIGR00367 243 SNIFNILVGLGVPSLFMpIPVEPLA---YNLDapvMVI--VTLLLMLFFKTSMKLGRWEGILLLALYIAY 307
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 153-206 2.19e-08

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 56.19  E-value: 2.19e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 442617342 153 VAGATFMAAGSSAPELATVVIGVFFAKDDIGISGVIGSAVFNIMFVISVCALCS 206
Cdd:PRK10734 210 TIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALIS 263
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 115-202 5.49e-07

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 52.87  E-value: 5.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342  115 ILHILVAVFTFFGLAIVCDEyFVASLDRLCEELK----LSPD--------------VAGATFMAAGSSAPELATVVIGVF 176
Cdd:TIGR00845  76 TVYFVAMVYMFLGVSIIADR-FMASIEVITSQEKeitiKKPNgettvttvriwnetVSNLTLMALGSSAPEILLSVIEVC 154

                          90       100
                  ....*....|....*....|....*....
gi 442617342  177 ---FAKDDIGISGVIGSAVFNIMFVISVC 202
Cdd:TIGR00845 155 ghnFEAGDLGPSTIVGSAAFNMFIIIAIC 183
caca2 TIGR00846
calcium/proton exchanger; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the ...
 130-258 1.34e-05

calcium/proton exchanger; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is generated from the calcium ion/proton exchangers of the CacA family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273297 [Multi-domain]  Cd Length: 363  Bit Score: 47.84  E-value: 1.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617342  130 IVCDEYFVASLDRLCEELKLSPDVAGATFMAAGSSAPELATVVIGVFFAKDDIGISGVIGSAVFNIMFVISVCALCS--- 206
Cdd:TIGR00846 232 ILLADYLVDTIDDAVDSWGLSVAFIGLILAPIVGNAAEHVTAVKAALKNKLDLALGVALGSALQIILFVVPLVVLVAwml 311

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 442617342  207 GTVCQLNWWPLVRDCFFycVSILVMLIIIFNDVISCFESVVMLLCYVGYCVA 258
Cdd:TIGR00846 312 GIPMDLNFGTFETIVLA--LSLFLTTITLQDGRSNYLEGAVLLALYIIIAMA 361
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 136-204 7.37e-03

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 38.86  E-value: 7.37e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442617342 136 FVASLdrLCEELKLSPDVAGATFMAAGSSAPELATVVIGVFFAKDDIGISGVIGSAVFNIMFVISVCAL 204
Cdd:PRK10734  24 FAASI--LCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLILGLAAL 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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