BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712  31 LVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFTQMPSNTHAIVFLNNVSHSALKDLIQFMYCGEVNVKQDALPAFISTAES 110
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                ....*
gi 24648712 111 LQIKG 115
Cdd:cd18315  81 LQIKG 85

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712  31 LVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFTQMPSNTHAIVFLNNVSHSALKDLIQFMYCGEVNVKQDALPAFISTAES 110
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                ....*
gi 24648712 111 LQIKG 115
Cdd:cd18315  81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712     33 DVSLAAEGQIVKAHRLVLSVCSPFFRKMFT-QMPSNTHAIVFLNNVSHSALKDLIQFMYCGEVNVKQDALPAFISTAESL 111
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSsDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*..
gi 24648712    112 QIKGLTD 118
Cdd:smart00225  81 QIPGLVE 87

kelch-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712   30 DLVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFtqmpSNTHAIVFLN-NVSHSALKDLIQFMYCGEVNVKQDALPAFISTA 108
Cdd:PHA03098  10 CDESIIIVNGGGIIKVHKIILSSSSEYFKKMF----KNNFKENEINlNIDYDSFNEVIKYIYTGKINITSNNVKDILSIA 85

                         90
                 ....*....|
gi 24648712  109 ESLQIKGLTD 118
Cdd:PHA03098  86 NYLIIDFLIN 95

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712  31 LVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFTQMPSNTHAIVFLNNVSHSALKDLIQFMYCGEVNVKQDALPAFISTAES 110
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                ....*
gi 24648712 111 LQIKG 115
Cdd:cd18315  81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712     33 DVSLAAEGQIVKAHRLVLSVCSPFFRKMFT-QMPSNTHAIVFLNNVSHSALKDLIQFMYCGEVNVKQDALPAFISTAESL 111
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSsDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*..
gi 24648712    112 QIKGLTD 118
Cdd:smart00225  81 QIPGLVE 87

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712  23 HESLCRGDLVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFT-QMPSNTHAIVFLNNVSHSALKDLIQFMYCGEVNVKQDAL 101
Cdd:cd18238   7 HQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTsEMAESKQDSITIKDIDEEAVELLVDFAYTGKLTLTVDNV 86

                        90
                ....*....|..
gi 24648712 102 PAFISTAESLQI 113
Cdd:cd18238  87 QSLLYAASLLQV 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712  28 RGDLVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFTQ-MPSNTHAIVFLNNVSHSALKDLIQFMYCGEVNVKQDALPAFIS 106
Cdd:cd18255  15 KGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGgMRESSQDEIELKGVSAKGLKHILDFAYTSELTLDLDCIQDVLG 94

                ....*..
gi 24648712 107 TAESLQI 113
Cdd:cd18255  95 AAVHLQM 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712  21 GFHESLCRGDLVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFT-QMPSNTHAIVFLNNVSHSALKDLIQFMYCGEVNVKQD 99
Cdd:cd18257   8 GLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTgNLSEKENSEVEFQCIDETALQAIVEYAYTGTVFISQA 87

                        90
                ....*....|....*
gi 24648712 100 ALPAFISTAESLQIK 114
Cdd:cd18257  88 TVESLLPAANLLQIK 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712  29 GDLVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFT-QMPSNTHAIVFLNNVSHSALKDLIQFMYCGEVNVKQDALPAFIST 107
Cdd:cd18265  21 GTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGgHLKESRQAVVEIQKVSAAAMEVLLDYMYGGGLRIQEDNVESVLEA 100

                        90
                ....*....|.
gi 24648712 108 AESLQIKGLTD 118
Cdd:cd18265 101 SDLLQVSKLRE 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712  28 RGDLVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFTQ--MPSNTHAIVfLNNVSHSALKDLIQFMYCGEVNVKQDALPAFI 105
Cdd:cd18247  16 QGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHdmVESKQDEIT-MQGIEPSALEALINFAYSGRIAIDTSNVQSLL 94

                ....*...
gi 24648712 106 STAESLQI 113
Cdd:cd18247  95 VGASFLQL 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712  28 RGDLVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFT-QMPSNTHAIVFLNNVSHSALKDLIQFMYCGEVNVKQDALPAFIS 106
Cdd:cd18246  36 RGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTnEMSESRQTHVTLHDIDPQALEQLVQYAYTAEIVVGEGNVQTLLP 115

                        90
                ....*....|..
gi 24648712 107 TAESLQIKGLTD 118
Cdd:cd18246 116 AASLLQLNGVRD 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712  31 LVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFT-QMPSNTHAIVFLNNVSHSALKDLIQFMYCGEVNVKQDALPAFISTAE 109
Cdd:cd18339  21 LCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTgDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAAS 100

                ....
gi 24648712 110 SLQI 113
Cdd:cd18339 101 LLQL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712  22 FHESLCRGDLVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFTQMPSNTHAIVF-LNNVSHSALKDLIQFMYCGEVNVKQDA 100
Cdd:cd18240   8 FNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYkIPGVSPEMMELIIEYAYTRTVPITAEN 87

                        90
                ....*....|....*.
gi 24648712 101 LPAFISTAESLQIKGL 116
Cdd:cd18240  88 VEELLPAADQFNIMGI 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712  17 NLSAGFHESLCRGDLVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFTQMPSNTHAI-VFLNNVSHSALKDLIQFMYCGEVN 95
Cdd:cd18250   7 HLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADrVVLHGVSAEILGLLLDFSYTGRVT 86

                        90
                ....*....|....*..
gi 24648712  96 VKQDALPAFISTAESLQ 112
Cdd:cd18250  87 VTQDNVEALLRAADLFQ 103

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712  28 RGDLVDVSLAA-EGQIVKAHRLVLSVCSPFFRKMFTQMPSNTHAIVFLNNVSHSALKDLIQFMYCGEVNVKQDALPAFIS 106
Cdd:cd18311  11 KTEYCDLTLQFrDNEQLKVHRLVLSACTDYFNVLEQTCEIVDDTLIMPNELQADAVVPVINFMYTGQLEFEEKSYGKLLR 90

                ....*..
gi 24648712 107 TAESLQI 113
Cdd:cd18311  91 TAKELNM 97

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712  33 DVSLAAEGQIVKAHRLVLSVCSPFFRKMFTQ-MPSNTHAIVFLNNVSHSALKDLIQFMYCGEVNVKQDALPAFISTAESL 111
Cdd:cd18263  15 DVQLEADGSIFRVHRVILAAGSDYFRAMFTSgMKESTQSVVQLPTIPAKDLRLLISFAYSGILHLSWENLFEATCTALQL 94

                ....*
gi 24648712 112 QIKGL 116
Cdd:cd18263  95 QISGA 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712  13 NFNTNLSAGFHESLCRGDLVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFTQMPSNTHAIVF-LNNVSHSALKDLIQFMYC 91
Cdd:cd18198   7 DHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYeIDFVSPEALTALLEFAYT 86

                        90       100
                ....*....|....*....|..
gi 24648712  92 GEVNVKQDALPAFISTAESLQI 113
Cdd:cd18198  87 ATLTVSTANVGDILSAARLLEI 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712  31 LVDVSLAAEGQIVKAHRLVLSVCSPFFRKMF-TQMPSNTHAIVFLNNVSHSALKDLIQFMYCGEVNVKQDALPAFISTAE 109
Cdd:cd18271  24 FFDFNIIVKDETIPCHRCVLAACSDFFRAMFeVNMKERDDGSVTISNLSPKAVKAFLDYAYTGKAEITDDNVEMFFQMSS 103

                ....
gi 24648712 110 SLQI 113
Cdd:cd18271 104 FLQV 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712  31 LVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFTQMPS-NTHAIVFLNNVSHSALKDLIQFMYCGEV---NVKQDALPAFIS 106
Cdd:cd18297  12 MSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTeAQTPVIEIPDIRYDIFQLMMQYLYTGGVeslDVAQDDALELLR 91

                        90
                ....*....|
gi 24648712 107 TAESLQIKGL 116
Cdd:cd18297  92 AASFFQLDGL 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712  31 LVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFT-QMPSNTHAIVFLNNVSHSALKDLIQFMYCGEVNVKQDALPAFISTAE 109
Cdd:cd18259  32 LSDVTLLVGGREFPCHRSVLALCSHYFNAMFTgDFVESISARVEIKDVDPAVMESLIDFAYTGKLTINQGNVEALIRTSN 111

                ...
gi 24648712 110 SLQ 112
Cdd:cd18259 112 RLQ 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712  28 RGDLVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFT-QMPSNTHAIVFLNNVSHSALKDLIQFMYCGEVNVKQDALPAFIS 106
Cdd:cd18331  21 RDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTdQLKCNLSVINLDPEINPEGFNILLDFMYTSRLNLREGNIMAVMA 100

                        90
                ....*....|..
gi 24648712 107 TAESLQIKGLTD 118
Cdd:cd18331 101 TAMYLQMEHVVD 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712  23 HESLCrgdlvDVSLAAEGQIVKAHRLVLSVCSPFFRKMFTQ-MPSNTHAIVFLNNVSHSALKDLIQFMYCGEVNVKQDAL 101
Cdd:cd18336  16 HKQLC-----DVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNdVREAKQEEIKMEGVDPDALKALVHYAYTGVLELKEDTI 90

                        90
                ....*....|....*..
gi 24648712 102 PAFISTAESLQIKGLTD 118
Cdd:cd18336  91 ESLLAAACLLQLSQVID 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712  15 NTNLSAGFHESLCRGDLVDVSLAAEGQIVKAHRLVLSVCSPFFRKMF-TQMPSNTHAIVFLNNVSHSALKDLIQFMYCGE 93
Cdd:cd18341  11 STLLQDGLKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFlSEESEEKKKEVVLDNVDPNIMDMILKYLYSAE 90

                        90       100
                ....*....|....*....|
gi 24648712  94 VNVKQDALPAFISTAESLQI 113
Cdd:cd18341  91 IDLNDGNVQDIFALASRFQI 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712  22 FHESLCRGDLVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFTQMPSNTHAIVFLNNVSHSALKDLIQFMYCGEVNVKQDAL 101
Cdd:cd18233   9 LHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNSSSQKNDVFHLDIKNVGGIGQILDFMYTSHLDLNQDNV 88

                        90
                ....*....|...
gi 24648712 102 PAFISTAESLQIK 114
Cdd:cd18233  89 QVMLDIAQCLQVQ 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712  13 NFNTNLSAGFHESLCRGDLVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFTqmpSNTHAIVFL-NNVSHSALKDLIQFMYC 91
Cdd:cd18290   9 NFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFN---SSRSAVVELpAAVQPQSFQQILSFCYT 85

                        90       100
                ....*....|....*....|....*..
gi 24648712  92 GEVNVKQDALPAFISTAESLQIKGLTD 118
Cdd:cd18290  86 GRLSMNVGDQFLLMYTAGFLQIQEIME 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712  22 FHESLCRGDLVDVSL-AAEGQIVKAHRLVLSVCSPFFRKMFT-QMPSNTHAIVFLNNVSHSALKDLIQFMYCGEVNVKQD 99
Cdd:cd18252  12 FRTFYLDGLFTDITLqCASGQIFHCHKAALAACSSYFKVMFTaDMKEKSNNVIKLSGIDHDILEALVNYVYTSQICITER 91

                        90
                ....*....|...
gi 24648712 100 ALPAFISTAESLQ 112
Cdd:cd18252  92 NVQSLLEAADLLQ 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712  20 AGFHESLCRGDLVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFTQ-MPSNTHAIVFLNNVSHSALKDLIQFMYCGEVNVKQ 98
Cdd:cd18326  14 SSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSgAVVDQQNVYEIDFVSAEALTALLDFAYTATLTVST 93

                        90       100
                ....*....|....*....|
gi 24648712  99 DALPAFISTAESLQIKGLTD 118
Cdd:cd18326  94 SNVGDILSAARLLEIPAVSH 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712  31 LVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFTQMPSNThaIVFLNNVSHSALKDLIQFMYCGEVNVKQDALPAFISTAES 110
Cdd:cd18260  18 LCDLTIATKTKSFDVHKVVMASCSEYFRNILKKDPSLQ--RVELNDISPLGLATVITYAYTGKLTLSLYTIGSTISAASY 95

                ....*.
gi 24648712 111 LQIKGL 116
Cdd:cd18260  96 LQIHAL 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712  33 DVSLAAEGQIVKAHRLVLSVCSPFFRKM---FTQMPsnthaIVFLNNVSHSALKDLIQFMYCGEVNVK-QDALPAFISTA 108
Cdd:cd18221  20 DITLIVDGHQFKAHKAVLAACSQFFYKFfqdFTQEP-----LVEIEGVSNMAFRHLIEFTYTAKLMVQgEEEANDVWKAA 94

                ....*.
gi 24648712 109 ESLQIK 114
Cdd:cd18221  95 EYLQMQ 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712  26 LCRGD--LVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFTQMPSNTH-AIVFLNNVSHSALKDLIQFMYCGEVNVKQDALP 102
Cdd:cd18272  25 LCLEDglFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARnRVIELKDVSESVFQLLVDYIYHGTVKLRVEELQ 104

                        90
                ....*....|....
gi 24648712 103 AFISTAESLQIKGL 116
Cdd:cd18272 105 ETYEVADMYQLTAL 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648712  13 NFNTNLSAGFHESLCRGDLVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFTQmpSNTHAIVFLNNVSHSALKDLIQFMYCG 92
Cdd:cd18289  11 NFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSG--NSKSAFELPATVPPACFQQILSFCYTG 88

                        90       100
                ....*....|....*....|....*.
gi 24648712  93 EVNVKQDALPAFISTAESLQIKGLTD 118
Cdd:cd18289  89 KLTMAASEQLVVMYTAGFLQIQHIVE 114