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Conserved domains on  [gi|78042605|ref|NP_742040|]
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mannan-binding lectin serine protease 2 isoform 1 precursor [Rattus norvegicus]

Protein Classification

serine protease( domain architecture ID 10806436)

trypsin-like serine protease such as human plasminogen, the precursor of the widely distributed protease plasmin, or granzyme B, a human enzyme necessary for target cell lysis in cell-mediated immune responses

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 444-681 2.95e-80

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


:

Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 254.51  E-value: 2.95e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605 444 IIGGQPAKPGDFPWQVLL---LGETTAAGALIHDDWVLTAAHAVYGKteAMSSLDIRMGILKRLSPHYTQ--AWPEAVFI 518
Cdd:cd00190   1 IVGGSEAKIGSFPWQVSLqytGGRHFCGGSLISPRWVLTAAHCVYSS--APSNYTVRLGSHDLSSNEGGGqvIKVKKVIV 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605 519 HEGYtHGAGFDNDIALIKLKNKVTINRNIMPICLPRKEaaSLMKTDFVGTVAGWGLTQ-KGFLARNLMFVDIPIVDHQKC 597
Cdd:cd00190  79 HPNY-NPSTYDNDIALLKLKRPVTLSDNVRPICLPSSG--YNLPAGTTCTVSGWGRTSeGGPLPDVLQEVNVPIVSNAEC 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605 598 ATAYtkqpYPGAKVTVNMLCAGLDAGGKDSCRGDSGGALVFLDNEtqRWFVGGIVSWGSiNCGGSEQYGVYTKVTNYIPW 677
Cdd:cd00190 156 KRAY----SYGGTITDNMLCAGGLEGGKDACQGDSGGPLVCNDNG--RGVLVGIVSWGS-GCARPNYPGVYTRVSSYLDW 228


                ....
gi 78042605 678 IENI 681
Cdd:cd00190 229 IQKT 232
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 184-295 3.25e-31

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 117.90  E-value: 3.25e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605 184 CSGQVFTGRSGFLSSPEYPQPYPKLSSCAYNIRLEEGFSITLDFvESFDVEMHPeaQCPYDSLKI----QTDKREYGPFC 259
Cdd:cd00041   1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTF-EDFDLESSP--NCSYDYLEIydgpSTSSPLLGRFC 77

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 78042605 260 GKTLPPRIETDSNKVTITFTTDESGNHTGWKIHYTS 295
Cdd:cd00041  78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 19-136 3.65e-26

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 103.26  E-value: 3.65e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605  19 GSKWPEPVFGRLVSPGFPEKYGNHQDRSWTLTAPPGFRLRLYFTHFNLELSYRCEYDFVKLTSG----TKVLATLCGQES 94
Cdd:cd00041   2 GGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGpstsSPLLGRFCGSTL 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 78042605  95 tdterapgNDTFYSLGPSLKVTFHSDYSNEKpfTGFEAFYAA 136
Cdd:cd00041  82 --------PPPIISSGNSLTVRFRSDSSVTG--RGFKATYSA 113
Sushi pfam00084
Sushi repeat (SCR repeat);
300-361 4.07e-11

Sushi repeat (SCR repeat);


:

Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 58.66  E-value: 4.07e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 78042605   300 CPDPTAPPNGHISPVQATYVLKDSFSVFCKTGFElLQGsvplkSFTAVCQKDGSWDRPIPEC 361
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYR-LVG-----SPTITCQEDGTWSPPFPEC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
366-429 2.83e-08

Sushi repeat (SCR repeat);


:

Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 50.58  E-value: 2.83e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 78042605   366 CGPPDDLPNGHVdyITGPEVTTYKAVIQYSCEETFYTMSSNgKYVCEADGFWTSSKgekslPVC 429
Cdd:pfam00084   1 CPPPPDIPNGKV--SATKNEYNYGASVSYECDPGYRLVGSP-TITCQEDGTWSPPF-----PEC 56
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 152-180 5.10e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 46.47  E-value: 5.10e-07
                          10        20
                  ....*....|....*....|....*....
gi 78042605   152 CDHYCHNYLGGYYCSCRVGYILHQNKHTC 180
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
 
Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 444-681 2.95e-80

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 254.51  E-value: 2.95e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605 444 IIGGQPAKPGDFPWQVLL---LGETTAAGALIHDDWVLTAAHAVYGKteAMSSLDIRMGILKRLSPHYTQ--AWPEAVFI 518
Cdd:cd00190   1 IVGGSEAKIGSFPWQVSLqytGGRHFCGGSLISPRWVLTAAHCVYSS--APSNYTVRLGSHDLSSNEGGGqvIKVKKVIV 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605 519 HEGYtHGAGFDNDIALIKLKNKVTINRNIMPICLPRKEaaSLMKTDFVGTVAGWGLTQ-KGFLARNLMFVDIPIVDHQKC 597
Cdd:cd00190  79 HPNY-NPSTYDNDIALLKLKRPVTLSDNVRPICLPSSG--YNLPAGTTCTVSGWGRTSeGGPLPDVLQEVNVPIVSNAEC 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605 598 ATAYtkqpYPGAKVTVNMLCAGLDAGGKDSCRGDSGGALVFLDNEtqRWFVGGIVSWGSiNCGGSEQYGVYTKVTNYIPW 677
Cdd:cd00190 156 KRAY----SYGGTITDNMLCAGGLEGGKDACQGDSGGPLVCNDNG--RGVLVGIVSWGS-GCARPNYPGVYTRVSSYLDW 228


                ....
gi 78042605 678 IENI 681
Cdd:cd00190 229 IQKT 232
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 443-678 4.30e-80

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 254.14  E-value: 4.30e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605    443 RIIGGQPAKPGDFPWQVLLL---GETTAAGALIHDDWVLTAAHAVYGKTEamSSLDIRMGILKRLSPHYTQAWP-EAVFI 518
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLQyggGRHFCGGSLISPRWVLTAAHCVRGSDP--SNIRVRLGSHDLSSGEEGQVIKvSKVII 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605    519 HEGYtHGAGFDNDIALIKLKNKVTINRNIMPICLPRKeaASLMKTDFVGTVAGWGLTQ--KGFLARNLMFVDIPIVDHQK 596
Cdd:smart00020  79 HPNY-NPSTYDNDIALLKLKEPVTLSDNVRPICLPSS--NYNVPAGTTCTVSGWGRTSegAGSLPDTLQEVNVPIVSNAT 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605    597 CATAYtkqpYPGAKVTVNMLCAGLDAGGKDSCRGDSGGALVFLDNetqRWFVGGIVSWGSiNCGGSEQYGVYTKVTNYIP 676
Cdd:smart00020 156 CRRAY----SGGGAITDNMLCAGGLEGGKDACQGDSGGPLVCNDG---RWVLVGIVSWGS-GCARPGKPGVYTRVSSYLD 227


                   ..
gi 78042605    677 WI 678
Cdd:smart00020 228 WI 229
Trypsin pfam00089
Trypsin;
444-678 1.96e-58

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 196.51  E-value: 1.96e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605   444 IIGGQPAKPGDFPWQVLLL---GETTAAGALIHDDWVLTAAHAVYGKteamSSLDIRMGILKRlspHYTQAWP-----EA 515
Cdd:pfam00089   1 IVGGDEAQPGSFPWQVSLQlssGKHFCGGSLISENWVLTAAHCVSGA----SDVKVVLGAHNI---VLREGGEqkfdvEK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605   516 VFIHEGYThGAGFDNDIALIKLKNKVTINRNIMPICLPRKEAASLMKTdfVGTVAGWGLTQKGFLARNLMFVDIPIVDHQ 595
Cdd:pfam00089  74 IIVHPNYN-PDTLDNDIALLKLESPVTLGDTVRPICLPDASSDLPVGT--TCTVSGWGNTKTLGPSDTLQEVTVPVVSRE 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605   596 KCATAYtkqpypGAKVTVNMLCAGldAGGKDSCRGDSGGALVFLDNETQrwfvgGIVSWGsINCGGSEQYGVYTKVTNYI 675
Cdd:pfam00089 151 TCRSAY------GGTVTDTMICAG--AGGKDACQGDSGGPLVCSDGELI-----GIVSWG-YGCASGNYPGVYTPVSSYL 216


                  ...
gi 78042605   676 PWI 678
Cdd:pfam00089 217 DWI 219
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 431-683 5.45e-56

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 191.40  E-value: 5.45e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605 431 PVCGLSTHTSGGRIIGGQPAKPGDFPWQVLLLGETTAA-----GALIHDDWVLTAAHAVYGktEAMSSLDIRMGILKRLS 505
Cdd:COG5640  18 ALAAAPAADAAPAIVGGTPATVGEYPWMVALQSSNGPSgqfcgGTLIAPRWVLTAAHCVDG--DGPSDLRVVIGSTDLST 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605 506 PHYTQAWPEAVFIHEGYThGAGFDNDIALIKLKNKVTinrNIMPICLPrkEAASLMKTDFVGTVAGWGLT--QKGFLARN 583
Cdd:COG5640  96 SGGTVVKVARIVVHPDYD-PATPGNDIALLKLATPVP---GVAPAPLA--TSADAAAPGTPATVAGWGRTseGPGSQSGT 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605 584 LMFVDIPIVDHQKCATaytkqpYPGAkVTVNMLCAGLDAGGKDSCRGDSGGALVFLDNEtqRWFVGGIVSWGSINCGGSe 663
Cdd:COG5640 170 LRKADVPVVSDATCAA------YGGF-DGGTMLCAGYPEGGKDACQGDSGGPLVVKDGG--GWVLVGVVSWGGGPCAAG- 239

                       250       260
                ....*....|....*....|
gi 78042605 664 QYGVYTKVTNYIPWIENIIN 683
Cdd:COG5640 240 YPGVYTRVSAYRDWIKSTAG 259
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 184-295 3.25e-31

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 117.90  E-value: 3.25e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605 184 CSGQVFTGRSGFLSSPEYPQPYPKLSSCAYNIRLEEGFSITLDFvESFDVEMHPeaQCPYDSLKI----QTDKREYGPFC 259
Cdd:cd00041   1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTF-EDFDLESSP--NCSYDYLEIydgpSTSSPLLGRFC 77

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 78042605 260 GKTLPPRIETDSNKVTITFTTDESGNHTGWKIHYTS 295
Cdd:cd00041  78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB pfam00431
CUB domain;
184-293 4.21e-29

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 111.62  E-value: 4.21e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605   184 CSGqVFTGRSGFLSSPEYPQPYPKLSSCAYNIRLEEGFSITLDFvESFDVEMHPEaqCPYDSLKIQ----TDKREYGPFC 259
Cdd:pfam00431   1 CGG-VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTF-QDFELEDHDE--CGYDYVEIRdgpsASSPLLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 78042605   260 GKTLPPRIETDSNKVTITFTTDESGNHTGWKIHY 293
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 19-136 3.65e-26

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 103.26  E-value: 3.65e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605  19 GSKWPEPVFGRLVSPGFPEKYGNHQDRSWTLTAPPGFRLRLYFTHFNLELSYRCEYDFVKLTSG----TKVLATLCGQES 94
Cdd:cd00041   2 GGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGpstsSPLLGRFCGSTL 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 78042605  95 tdterapgNDTFYSLGPSLKVTFHSDYSNEKpfTGFEAFYAA 136
Cdd:cd00041  82 --------PPPIISSGNSLTVRFRSDSSVTG--RGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 194-293 3.67e-26

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 102.85  E-value: 3.67e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605    194 GFLSSPEYPQPYPKLSSCAYNIRLEEGFSITLDFvESFDVEMHPEaqCPYDSLKIQ----TDKREYGPFCGKTLPPR-IE 268
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQF-TDFDLESSDN--CEYDYVEIYdgpsASSPLLGRFCGSEAPPPvIS 77

                           90       100
                   ....*....|....*....|....*
gi 78042605    269 TDSNKVTITFTTDESGNHTGWKIHY 293
Cdd:smart00042  78 SSSNSLTLTFVSDSSVQKRGFSARY 102
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 28-134 1.43e-25

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 101.31  E-value: 1.43e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605     28 GRLVSPGFPEKYGNHQDRSWTLTAPPGFRLRLYFTHFNLELSYRCEYDFVKLTSG----TKVLATLCGQEstdteraPGN 103
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGpsasSPLLGRFCGSE-------APP 73

                           90       100       110
                   ....*....|....*....|....*....|.
gi 78042605    104 DTFYSLGPSLKVTFHSDYSNEKpfTGFEAFY 134
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQK--RGFSARY 102
CUB pfam00431
CUB domain;
27-134 8.17e-16

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 73.87  E-value: 8.17e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605    27 FGRLVSPGFPEKYGNHQDRSWTLTAPPGFRLRLYFTHFNLELSYRCEYDFVKLTSG----TKVLATLCGQEstdterAPg 102
Cdd:pfam00431   9 SGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGpsasSPLLGRFCGSG------IP- 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 78042605   103 nDTFYSLGPSLKVTFHSDYSNEKpfTGFEAFY 134
Cdd:pfam00431  82 -EDIVSSSNQMTIKFVSDASVQK--RGFKATY 110
Sushi pfam00084
Sushi repeat (SCR repeat);
300-361 4.07e-11

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 58.66  E-value: 4.07e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 78042605   300 CPDPTAPPNGHISPVQATYVLKDSFSVFCKTGFElLQGsvplkSFTAVCQKDGSWDRPIPEC 361
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYR-LVG-----SPTITCQEDGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 300-361 1.35e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 57.15  E-value: 1.35e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 78042605    300 CPDPTAPPNGHISPVQATYVLKDSFSVFCKTGFELLQGSvplksfTAVCQKDGSWDRPIPEC 361
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSS------TITCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 300-361 1.52e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 57.09  E-value: 1.52e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 78042605 300 CPDPTAPPNGHISPVQATYVLKDSFSVFCKTGFELLQgsvplkSFTAVCQKDGSWDRPIPEC 361
Cdd:cd00033   1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVG------SSTITCTENGGWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
366-429 2.83e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 50.58  E-value: 2.83e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 78042605   366 CGPPDDLPNGHVdyITGPEVTTYKAVIQYSCEETFYTMSSNgKYVCEADGFWTSSKgekslPVC 429
Cdd:pfam00084   1 CPPPPDIPNGKV--SATKNEYNYGASVSYECDPGYRLVGSP-TITCQEDGTWSPPF-----PEC 56
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 152-180 5.10e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 46.47  E-value: 5.10e-07
                          10        20
                  ....*....|....*....|....*....
gi 78042605   152 CDHYCHNYLGGYYCSCRVGYILHQNKHTC 180
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 366-430 1.29e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 45.92  E-value: 1.29e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 78042605 366 CGPPDDLPNGHVDYITGPevTTYKAVIQYSCEETfYTMSSNGKYVCEADGFWTSskgekSLPVCK 430
Cdd:cd00033   1 CPPPPVPENGTVTGSKGS--YSYGSTVTYSCNEG-YTLVGSSTITCTENGGWSP-----PPPTCE 57
PHA02817 PHA02817
EEV Host range protein; Provisional
 300-429 3.53e-06

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 48.78  E-value: 3.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605  300 CPDPTAPPNGHISPVQATYVLKDSFSVFCKTGFELLQGSVpLKSFTAVCQKDGSWDRPIPECSIIDCGPPdDLPNGHVDY 379
Cdd:PHA02817  24 CCYPPSIKNGYIYNKKTEYNIGSNVTFFCGNNTRGVRYTL-VGEKNIICEKDGKWNKEFPVCKIIRCRFP-ALQNGFVNG 101

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 78042605  380 ITGPEVTTYKAVIQYSCEETFYTMSSngKY-VCEADGFWTSskgekSLPVC 429
Cdd:PHA02817 102 IPDSKKFYYESEVSFSCKPGFVLIGT--KYsVCGINSSWIP-----KVPIC 145
EGF_CA smart00179
Calcium-binding EGF-like domain;
138-176 1.01e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 1.01e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 78042605    138 DVDECRTSlgdsVPCDH--YCHNYLGGYYCSCRVGYILHQN 176
Cdd:smart00179   1 DIDECASG----NPCQNggTCVNTVGSYRCECPPGYTDGRN 37
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 366-429 1.91e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 42.51  E-value: 1.91e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 78042605    366 CGPPDDLPNGHVDYITGPevTTYKAVIQYSCEETfYTMSSNGKYVCEADGFWTSskgekSLPVC 429
Cdd:smart00032   1 CPPPPDIENGTVTSSSGT--YSYGDTVTYSCDPG-YTLIGSSTITCLENGTWSP-----PPPTC 56
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 138-174 3.01e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 3.01e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 78042605 138 DVDECRTSlgdsVPCDHY--CHNYLGGYYCSCRVGYILH 174
Cdd:cd00054   1 DIDECASG----NPCQNGgtCVNTVGSYRCSCPPGYTGR 35
 
Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 444-681 2.95e-80

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 254.51  E-value: 2.95e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605 444 IIGGQPAKPGDFPWQVLL---LGETTAAGALIHDDWVLTAAHAVYGKteAMSSLDIRMGILKRLSPHYTQ--AWPEAVFI 518
Cdd:cd00190   1 IVGGSEAKIGSFPWQVSLqytGGRHFCGGSLISPRWVLTAAHCVYSS--APSNYTVRLGSHDLSSNEGGGqvIKVKKVIV 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605 519 HEGYtHGAGFDNDIALIKLKNKVTINRNIMPICLPRKEaaSLMKTDFVGTVAGWGLTQ-KGFLARNLMFVDIPIVDHQKC 597
Cdd:cd00190  79 HPNY-NPSTYDNDIALLKLKRPVTLSDNVRPICLPSSG--YNLPAGTTCTVSGWGRTSeGGPLPDVLQEVNVPIVSNAEC 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605 598 ATAYtkqpYPGAKVTVNMLCAGLDAGGKDSCRGDSGGALVFLDNEtqRWFVGGIVSWGSiNCGGSEQYGVYTKVTNYIPW 677
Cdd:cd00190 156 KRAY----SYGGTITDNMLCAGGLEGGKDACQGDSGGPLVCNDNG--RGVLVGIVSWGS-GCARPNYPGVYTRVSSYLDW 228


                ....
gi 78042605 678 IENI 681
Cdd:cd00190 229 IQKT 232
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 443-678 4.30e-80

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 254.14  E-value: 4.30e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605    443 RIIGGQPAKPGDFPWQVLLL---GETTAAGALIHDDWVLTAAHAVYGKTEamSSLDIRMGILKRLSPHYTQAWP-EAVFI 518
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLQyggGRHFCGGSLISPRWVLTAAHCVRGSDP--SNIRVRLGSHDLSSGEEGQVIKvSKVII 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605    519 HEGYtHGAGFDNDIALIKLKNKVTINRNIMPICLPRKeaASLMKTDFVGTVAGWGLTQ--KGFLARNLMFVDIPIVDHQK 596
Cdd:smart00020  79 HPNY-NPSTYDNDIALLKLKEPVTLSDNVRPICLPSS--NYNVPAGTTCTVSGWGRTSegAGSLPDTLQEVNVPIVSNAT 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605    597 CATAYtkqpYPGAKVTVNMLCAGLDAGGKDSCRGDSGGALVFLDNetqRWFVGGIVSWGSiNCGGSEQYGVYTKVTNYIP 676
Cdd:smart00020 156 CRRAY----SGGGAITDNMLCAGGLEGGKDACQGDSGGPLVCNDG---RWVLVGIVSWGS-GCARPGKPGVYTRVSSYLD 227


                   ..
gi 78042605    677 WI 678
Cdd:smart00020 228 WI 229
Trypsin pfam00089
Trypsin;
444-678 1.96e-58

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 196.51  E-value: 1.96e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605   444 IIGGQPAKPGDFPWQVLLL---GETTAAGALIHDDWVLTAAHAVYGKteamSSLDIRMGILKRlspHYTQAWP-----EA 515
Cdd:pfam00089   1 IVGGDEAQPGSFPWQVSLQlssGKHFCGGSLISENWVLTAAHCVSGA----SDVKVVLGAHNI---VLREGGEqkfdvEK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605   516 VFIHEGYThGAGFDNDIALIKLKNKVTINRNIMPICLPRKEAASLMKTdfVGTVAGWGLTQKGFLARNLMFVDIPIVDHQ 595
Cdd:pfam00089  74 IIVHPNYN-PDTLDNDIALLKLESPVTLGDTVRPICLPDASSDLPVGT--TCTVSGWGNTKTLGPSDTLQEVTVPVVSRE 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605   596 KCATAYtkqpypGAKVTVNMLCAGldAGGKDSCRGDSGGALVFLDNETQrwfvgGIVSWGsINCGGSEQYGVYTKVTNYI 675
Cdd:pfam00089 151 TCRSAY------GGTVTDTMICAG--AGGKDACQGDSGGPLVCSDGELI-----GIVSWG-YGCASGNYPGVYTPVSSYL 216


                  ...
gi 78042605   676 PWI 678
Cdd:pfam00089 217 DWI 219
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 431-683 5.45e-56

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 191.40  E-value: 5.45e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605 431 PVCGLSTHTSGGRIIGGQPAKPGDFPWQVLLLGETTAA-----GALIHDDWVLTAAHAVYGktEAMSSLDIRMGILKRLS 505
Cdd:COG5640  18 ALAAAPAADAAPAIVGGTPATVGEYPWMVALQSSNGPSgqfcgGTLIAPRWVLTAAHCVDG--DGPSDLRVVIGSTDLST 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605 506 PHYTQAWPEAVFIHEGYThGAGFDNDIALIKLKNKVTinrNIMPICLPrkEAASLMKTDFVGTVAGWGLT--QKGFLARN 583
Cdd:COG5640  96 SGGTVVKVARIVVHPDYD-PATPGNDIALLKLATPVP---GVAPAPLA--TSADAAAPGTPATVAGWGRTseGPGSQSGT 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605 584 LMFVDIPIVDHQKCATaytkqpYPGAkVTVNMLCAGLDAGGKDSCRGDSGGALVFLDNEtqRWFVGGIVSWGSINCGGSe 663
Cdd:COG5640 170 LRKADVPVVSDATCAA------YGGF-DGGTMLCAGYPEGGKDACQGDSGGPLVVKDGG--GWVLVGVVSWGGGPCAAG- 239

                       250       260
                ....*....|....*....|
gi 78042605 664 QYGVYTKVTNYIPWIENIIN 683
Cdd:COG5640 240 YPGVYTRVSAYRDWIKSTAG 259
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 184-295 3.25e-31

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 117.90  E-value: 3.25e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605 184 CSGQVFTGRSGFLSSPEYPQPYPKLSSCAYNIRLEEGFSITLDFvESFDVEMHPeaQCPYDSLKI----QTDKREYGPFC 259
Cdd:cd00041   1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTF-EDFDLESSP--NCSYDYLEIydgpSTSSPLLGRFC 77

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 78042605 260 GKTLPPRIETDSNKVTITFTTDESGNHTGWKIHYTS 295
Cdd:cd00041  78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB pfam00431
CUB domain;
184-293 4.21e-29

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 111.62  E-value: 4.21e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605   184 CSGqVFTGRSGFLSSPEYPQPYPKLSSCAYNIRLEEGFSITLDFvESFDVEMHPEaqCPYDSLKIQ----TDKREYGPFC 259
Cdd:pfam00431   1 CGG-VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTF-QDFELEDHDE--CGYDYVEIRdgpsASSPLLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 78042605   260 GKTLPPRIETDSNKVTITFTTDESGNHTGWKIHY 293
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 19-136 3.65e-26

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 103.26  E-value: 3.65e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605  19 GSKWPEPVFGRLVSPGFPEKYGNHQDRSWTLTAPPGFRLRLYFTHFNLELSYRCEYDFVKLTSG----TKVLATLCGQES 94
Cdd:cd00041   2 GGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGpstsSPLLGRFCGSTL 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 78042605  95 tdterapgNDTFYSLGPSLKVTFHSDYSNEKpfTGFEAFYAA 136
Cdd:cd00041  82 --------PPPIISSGNSLTVRFRSDSSVTG--RGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 194-293 3.67e-26

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 102.85  E-value: 3.67e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605    194 GFLSSPEYPQPYPKLSSCAYNIRLEEGFSITLDFvESFDVEMHPEaqCPYDSLKIQ----TDKREYGPFCGKTLPPR-IE 268
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQF-TDFDLESSDN--CEYDYVEIYdgpsASSPLLGRFCGSEAPPPvIS 77

                           90       100
                   ....*....|....*....|....*
gi 78042605    269 TDSNKVTITFTTDESGNHTGWKIHY 293
Cdd:smart00042  78 SSSNSLTLTFVSDSSVQKRGFSARY 102
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 28-134 1.43e-25

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 101.31  E-value: 1.43e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605     28 GRLVSPGFPEKYGNHQDRSWTLTAPPGFRLRLYFTHFNLELSYRCEYDFVKLTSG----TKVLATLCGQEstdteraPGN 103
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGpsasSPLLGRFCGSE-------APP 73

                           90       100       110
                   ....*....|....*....|....*....|.
gi 78042605    104 DTFYSLGPSLKVTFHSDYSNEKpfTGFEAFY 134
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQK--RGFSARY 102
CUB pfam00431
CUB domain;
27-134 8.17e-16

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 73.87  E-value: 8.17e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605    27 FGRLVSPGFPEKYGNHQDRSWTLTAPPGFRLRLYFTHFNLELSYRCEYDFVKLTSG----TKVLATLCGQEstdterAPg 102
Cdd:pfam00431   9 SGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGpsasSPLLGRFCGSG------IP- 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 78042605   103 nDTFYSLGPSLKVTFHSDYSNEKpfTGFEAFY 134
Cdd:pfam00431  82 -EDIVSSSNQMTIKFVSDASVQK--RGFKATY 110
Sushi pfam00084
Sushi repeat (SCR repeat);
300-361 4.07e-11

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 58.66  E-value: 4.07e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 78042605   300 CPDPTAPPNGHISPVQATYVLKDSFSVFCKTGFElLQGsvplkSFTAVCQKDGSWDRPIPEC 361
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYR-LVG-----SPTITCQEDGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 300-361 1.35e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 57.15  E-value: 1.35e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 78042605    300 CPDPTAPPNGHISPVQATYVLKDSFSVFCKTGFELLQGSvplksfTAVCQKDGSWDRPIPEC 361
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSS------TITCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 300-361 1.52e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 57.09  E-value: 1.52e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 78042605 300 CPDPTAPPNGHISPVQATYVLKDSFSVFCKTGFELLQgsvplkSFTAVCQKDGSWDRPIPEC 361
Cdd:cd00033   1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVG------SSTITCTENGGWSPPPPTC 56
eMpr COG3591
V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, ...
 469-662 7.46e-09

V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442810 [Multi-domain]  Cd Length: 194  Bit Score: 55.84  E-value: 7.46e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605 469 GALIHDDWVLTAAHAVYGKTEA--MSSLDIRMGilkRLSPHYTQAWPEAVFIHEGYTHGAGFDNDIALIKLKNKVTINRN 546
Cdd:COG3591  16 GTLIGPNLVLTAGHCVYDGAGGgwATNIVFVPG---YNGGPYGTATATRFRVPPGWVASGDAGYDYALLRLDEPLGDTTG 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605 547 IMPIclprKEAASLMKTDFVgTVAGWGLTQKGFLARnlmfvdipivdHQKCATAYTKQPypgakvTVNMLCagldaggkD 626
Cdd:COG3591  93 WLGL----AFNDAPLAGEPV-TIIGYPGDRPKDLSL-----------DCSGRVTGVQGN------RLSYDC--------D 142

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 78042605 627 SCRGDSGGALvfLDNETQRWFVGGIVSWGSINCGGS 662
Cdd:COG3591 143 TTGGSSGSPV--LDDSDGGGRVVGVHSAGGADRANT 176
Sushi pfam00084
Sushi repeat (SCR repeat);
366-429 2.83e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 50.58  E-value: 2.83e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 78042605   366 CGPPDDLPNGHVdyITGPEVTTYKAVIQYSCEETFYTMSSNgKYVCEADGFWTSSKgekslPVC 429
Cdd:pfam00084   1 CPPPPDIPNGKV--SATKNEYNYGASVSYECDPGYRLVGSP-TITCQEDGTWSPPF-----PEC 56
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 152-180 5.10e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 46.47  E-value: 5.10e-07
                          10        20
                  ....*....|....*....|....*....
gi 78042605   152 CDHYCHNYLGGYYCSCRVGYILHQNKHTC 180
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 366-430 1.29e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 45.92  E-value: 1.29e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 78042605 366 CGPPDDLPNGHVDYITGPevTTYKAVIQYSCEETfYTMSSNGKYVCEADGFWTSskgekSLPVCK 430
Cdd:cd00033   1 CPPPPVPENGTVTGSKGS--YSYGSTVTYSCNEG-YTLVGSSTITCTENGGWSP-----PPPTCE 57
PHA02817 PHA02817
EEV Host range protein; Provisional
 300-429 3.53e-06

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 48.78  E-value: 3.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605  300 CPDPTAPPNGHISPVQATYVLKDSFSVFCKTGFELLQGSVpLKSFTAVCQKDGSWDRPIPECSIIDCGPPdDLPNGHVDY 379
Cdd:PHA02817  24 CCYPPSIKNGYIYNKKTEYNIGSNVTFFCGNNTRGVRYTL-VGEKNIICEKDGKWNKEFPVCKIIRCRFP-ALQNGFVNG 101

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 78042605  380 ITGPEVTTYKAVIQYSCEETFYTMSSngKY-VCEADGFWTSskgekSLPVC 429
Cdd:PHA02817 102 IPDSKKFYYESEVSFSCKPGFVLIGT--KYsVCGINSSWIP-----KVPIC 145
EGF_CA smart00179
Calcium-binding EGF-like domain;
138-176 1.01e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 1.01e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 78042605    138 DVDECRTSlgdsVPCDH--YCHNYLGGYYCSCRVGYILHQN 176
Cdd:smart00179   1 DIDECASG----NPCQNggTCVNTVGSYRCECPPGYTDGRN 37
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 366-429 1.91e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 42.51  E-value: 1.91e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 78042605    366 CGPPDDLPNGHVDYITGPevTTYKAVIQYSCEETfYTMSSNGKYVCEADGFWTSskgekSLPVC 429
Cdd:smart00032   1 CPPPPDIENGTVTSSSGT--YSYGDTVTYSCDPG-YTLIGSSTITCLENGTWSP-----PPPTC 56
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 138-174 3.01e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 3.01e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 78042605 138 DVDECRTSlgdsVPCDHY--CHNYLGGYYCSCRVGYILH 174
Cdd:cd00054   1 DIDECASG----NPCQNGgtCVNTVGSYRCSCPPGYTGR 35
EGF_CA pfam07645
Calcium-binding EGF domain;
138-170 9.87e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.91  E-value: 9.87e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 78042605   138 DVDECRTsLGDSVPCDHYCHNYLGGYYCSCRVG 170
Cdd:pfam07645   1 DVDECAT-GTHNCPANTVCVNTIGSFECRCPDG 32
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 287-441 2.91e-04

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 43.10  E-value: 2.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605  287 TGWKIHYTSTAQPCPDPTAPPNGHISPVQATYvlKDSFSVFCKTGFELLQGSvplKSFTAVcQKDGS--WDRPIPECSII 364
Cdd:PHA02927  73 TGWTLFNQCIKRRCPSPRDIDNGQLDIGGVDF--GSSITYSCNSGYQLIGES---KSYCEL-GSTGSmvWNPEAPICESV 146

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 78042605  365 DCGPPDDLPNG-HVDYitgPEVTTYKAVIQYSCeETFYTMSSNGKYVCEAdGFWTSSkgekslPVCKPV-CGLSTHTSG 441
Cdd:PHA02927 147 KCQSPPSISNGrHNGY---EDFYTDGSVVTYSC-NSGYSLIGNSGVLCSG-GEWSDP------PTCQIVkCPHPTISNG 214
PHA02639 PHA02639
EEV host range protein; Provisional
 298-432 3.50e-04

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 43.11  E-value: 3.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78042605  298 QPCPDPTAPPNGHISPVQATYVLKDSFSVFCKTGFELLQGSVPLKSFTavCQKDGSWDRPIPECSIIDCGPPdDLPNGHV 377
Cdd:PHA02639  83 KECNDPPSIINGKIYNKREMYKVGDEIYYVCNEHKGVQYSLVGNEKIT--CIQDKSWKPDPPICKMINCRFP-ALQNGYI 159

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 78042605  378 DYITGPEVTTYKAVIQYSCEETFYTMSSngKY-VCEADGFWTSskgekSLPVC---KPV 432
Cdd:PHA02639 160 NGIPSNKKFYYKTRVGFSCKSGFDLVGE--KYsTCNINATWFP-----SIPTCvrnKPI 211
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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