FAST kinase domain-containing protein 2, mitochondrial [Mus musculus]
Protein Classification
RAP domain-containing protein; Uma2 family endonuclease( domain architecture ID 10535838)
RAP domain-containing protein binds RNA, similar to Arabidopsis thaliana RAP domain-containing protein (AtRAP) that binds to the 16S rRNA precursor, is involved in its 5'-end processing, and is required for chloroplast 16S rRNA maturation, an important process which supports chloroplast gene expression and biogenesis| Uma2 family endonuclease belongs to the PDDEXK nuclease superfamily and may act as a restriction endonuclease
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| RESC6-like super family | cl46254 | RNA-editing substrate-binding complex subunit 6 (RESC6) and related proteins; RESC6 (GRBC6, ... |
168-415 | 3.42e-36 | |||||
RNA-editing substrate-binding complex subunit 6 (RESC6) and related proteins; RESC6 (GRBC6, MRB3010) is a component of the RNA-editing substrate-binding complex (RESC), that is composed of about 20 components and is involved in kinetoplast RNA processing. The mitochondrial DNA of Trypanosomatids, known as the kinetoplast DNA (kDNA or mtDNA), consists of a network of dozens of maxicircles and thousands of minicircles concatenated together. Maxicircles are equivalent to other eukaryotic mitochondrial DNAs, while minicircles encode guide RNAs (gRNAs) involved in U-insertion/deletion editing processes exclusive of Trypanosomatids that produce the maturation of the maxicircle-encoded transcripts. Although most gRNAs are encoded by minicircles, varying numbers of maxicircle-encoded gRNAs have been identified in kinetoplastids species. Trypanosoma brucei maxicircles encode 9S and 12S rRNAs, two gRNAs, two ribosomal proteins and 16 subunits of respiratory complexes. 12 of the 18 maxicircle genes are present as cryptogenes whose transcripts require U-insertion/deletion editing, mediated by gRNAs, to restore a protein-coding capacity. RESC interacts with two other complexes, the RNA-editing helicase 2 complex (REH2C) and RNA-editing catalytic complex (RECC) to form an assembly (editosome/holoenzyme) that carries out U-insertion/deletion mRNA editing. RESC6 is predicted (by AlphaFold) to adopt an all-helical structure with a disordered region at the N-terminus. The helical structure that is predicted with high confidence resembles Armadillo (ARM)/beta-catenin-like repeats. ARM repeats have been implicated in mediating protein-protein interactions. The actual alignment was detected with superfamily member cd23739: Pssm-ID: 480594 [Multi-domain] Cd Length: 249 Bit Score: 136.62 E-value: 3.42e-36
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| FAST_1 | pfam06743 | FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic ... |
442-514 | 3.38e-20 | |||||
FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2. : Pssm-ID: 461999 [Multi-domain] Cd Length: 72 Bit Score: 84.84 E-value: 3.38e-20
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| RAP | smart00952 | This domain is found in various eukaryotic species, particularly in apicomplexans; In ... |
619-675 | 3.69e-13 | |||||
This domain is found in various eukaryotic species, particularly in apicomplexans; In Plasmodium falciparum, the domain is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain. : Pssm-ID: 214932 Cd Length: 58 Bit Score: 64.56 E-value: 3.69e-13
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| Name | Accession | Description | Interval | E-value | |||||
| TBRG4-like_N | cd23739 | transforming growth factor beta (TGFbeta) regulator 4 (TBRG4) and similar proteins; predicted ... |
168-415 | 3.42e-36 | |||||
transforming growth factor beta (TGFbeta) regulator 4 (TBRG4) and similar proteins; predicted alpha-helical domain N-terminal to FAST kinase-like protein, subdomain 1 (FAST_1); TBRG4 also called cell cycle progression restoration protein 2 or Fas-activated serine-threonine (FAST) kinase domain-containing protein 4, is a regulator of TGFbeta and is implicated in numerous types of cancer. It serves a role in the tumorigenesis of lung cancer via deregulation of DNA damage-inducible transcript 3 (DDIT3), caveolin 1 (CAV1), and ribonucleotide reductase regulatory subunit M2 (RRM2). This domain lies N-terminal to the FAST_1 domain, and is predicted (by AlphaFold) to be alpha-helical, with similarity to structures of members of the 6-hairpin (6 helical hairpin) clan. Pssm-ID: 467932 [Multi-domain] Cd Length: 249 Bit Score: 136.62 E-value: 3.42e-36
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| FAST_1 | pfam06743 | FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic ... |
442-514 | 3.38e-20 | |||||
FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2. Pssm-ID: 461999 [Multi-domain] Cd Length: 72 Bit Score: 84.84 E-value: 3.38e-20
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| RAP | smart00952 | This domain is found in various eukaryotic species, particularly in apicomplexans; In ... |
619-675 | 3.69e-13 | |||||
This domain is found in various eukaryotic species, particularly in apicomplexans; In Plasmodium falciparum, the domain is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain. Pssm-ID: 214932 Cd Length: 58 Bit Score: 64.56 E-value: 3.69e-13
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| RAP | pfam08373 | RAP domain; This domain is found in various eukaryotic species, where it is found in proteins ... |
619-675 | 3.15e-10 | |||||
RAP domain; This domain is found in various eukaryotic species, where it is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain. The domain is involved in plant defence in response to bacterial infection. Pssm-ID: 429953 Cd Length: 58 Bit Score: 56.05 E-value: 3.15e-10
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| Name | Accession | Description | Interval | E-value | |||||
| TBRG4-like_N | cd23739 | transforming growth factor beta (TGFbeta) regulator 4 (TBRG4) and similar proteins; predicted ... |
168-415 | 3.42e-36 | |||||
transforming growth factor beta (TGFbeta) regulator 4 (TBRG4) and similar proteins; predicted alpha-helical domain N-terminal to FAST kinase-like protein, subdomain 1 (FAST_1); TBRG4 also called cell cycle progression restoration protein 2 or Fas-activated serine-threonine (FAST) kinase domain-containing protein 4, is a regulator of TGFbeta and is implicated in numerous types of cancer. It serves a role in the tumorigenesis of lung cancer via deregulation of DNA damage-inducible transcript 3 (DDIT3), caveolin 1 (CAV1), and ribonucleotide reductase regulatory subunit M2 (RRM2). This domain lies N-terminal to the FAST_1 domain, and is predicted (by AlphaFold) to be alpha-helical, with similarity to structures of members of the 6-hairpin (6 helical hairpin) clan. Pssm-ID: 467932 [Multi-domain] Cd Length: 249 Bit Score: 136.62 E-value: 3.42e-36
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| FAST_1 | pfam06743 | FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic ... |
442-514 | 3.38e-20 | |||||
FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2. Pssm-ID: 461999 [Multi-domain] Cd Length: 72 Bit Score: 84.84 E-value: 3.38e-20
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| RAP | smart00952 | This domain is found in various eukaryotic species, particularly in apicomplexans; In ... |
619-675 | 3.69e-13 | |||||
This domain is found in various eukaryotic species, particularly in apicomplexans; In Plasmodium falciparum, the domain is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain. Pssm-ID: 214932 Cd Length: 58 Bit Score: 64.56 E-value: 3.69e-13
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| RAP | pfam08373 | RAP domain; This domain is found in various eukaryotic species, where it is found in proteins ... |
619-675 | 3.15e-10 | |||||
RAP domain; This domain is found in various eukaryotic species, where it is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain. The domain is involved in plant defence in response to bacterial infection. Pssm-ID: 429953 Cd Length: 58 Bit Score: 56.05 E-value: 3.15e-10
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| RESC8-like | cd23736 | RNA-editing substrate-binding complex subunit 8 (RESC8) and related proteins; RESC8 (REMC1, ... |
366-496 | 2.32e-03 | |||||
RNA-editing substrate-binding complex subunit 8 (RESC8) and related proteins; RESC8 (REMC1, MRB10130) is a component of the RNA-editing substrate-binding complex (RESC) that is composed of about 20-components and is involved in kinetoplast RNA processing. RESC8 with RESC10, and RESC14 are RESC organizers which are important for modulating proper protein-protein-RNA rearrangements during editing. The mitochondrial DNA of Trypanosomatids, known as the kinetoplast DNA (kDNA or mtDNA), consists of a network of dozens of maxicircles and thousands of minicircles concatenated together. Maxicircles are equivalent to other eukaryotic mitochondrial DNAs, while minicircles encode guide RNAs (gRNAs) involved in U-insertion/deletion editing processes exclusive of Trypanosomatids that produce the maturation of the maxicircle-encoded transcripts. Although most gRNAs are encoded by minicircles, varying numbers of maxicircle-encoded gRNAs have been identified in kinetoplastids species. Trypanosoma brucei maxicircles encode 9S and 12S rRNAs, two gRNAs, two ribosomal proteins and 16 subunits of respiratory complexes. 12 of the 18 maxicircle genes are present as cryptogenes whose transcripts require U-insertion/deletion editing, mediated by gRNAs, to restore a protein-coding capacity. RESC interacts with two other complexes, the RNA-editing helicase 2 complex (REH2C) and RNA-editing catalytic complex (RECC) to form an assembly (editosome/holoenzyme) that carries out U-insertion/deletion mRNA editing. RESC8 is predicted (by AlphaFold) to adopt an all-helical structure, with a lower confidence in prediction of the N-terminal 100 residues. The helical structure that is predicted with high confidence, representing the middle and most of the C-terminal region, resembles Armadillo (ARM)/beta-catenin-like repeats. ARM repeats have been implicated in mediating protein-protein interactions. Pssm-ID: 467929 [Multi-domain] Cd Length: 514 Bit Score: 41.22 E-value: 2.32e-03
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