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Conserved domains on  [gi|261245013|ref|NP_766422|]
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lipoxygenase homology domain-containing protein 1 isoform 1 [Mus musculus]

Protein Classification

phospholipase C( domain architecture ID 10109880)

phospholipase C catayzes the hydroysis of a phosphatidylcholine to form 1,2-diacyl-sn-glycerol and phosphocholine

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 970-1090 9.07e-57

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 192.38  E-value: 9.07e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  970 TTFSVTIKTGDKKNAGTDANVFITLFGTQDNNGMTLLKSSkTNSDKFERDSIEIFTVETLDLGDLWKVRIGHDNTGKAPG 1049
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKS-NNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 261245013 1050 WFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIVRDLFHA 1090
Cdd:cd01756    80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 172-289 2.00e-55

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 188.53  E-value: 2.00e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  172 NKYEIKVYTGDVIGAGTDADVFINIFGEYGDTGERRLE--NEKDNFEKGAEDKFTLDAPDLGQLMKINVGHNNKGGSAGW 249
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKksNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 261245013  250 FLSKIIIEDIGNKRKYDFPLNRWLALDEDDGKIQRDILVG 289
Cdd:cd01756    81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1949-2067 3.57e-55

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 187.76  E-value: 3.57e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1949 VKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQK-MRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYYSGW 2027
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSnNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 261245013 2028 LVEKVEVTNTSTGVATIFSCGRWLDKSRGDGLTWRELFPS 2067
Cdd:cd01756    81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1255-1375 1.05e-53

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 183.91  E-value: 1.05e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1255 VLYSVQIFTGNVPGAGTDAKVYITIYGDLGDTGERYLGKSENRtNKFEKGTADTFIIEAADLGVIYKIKLRHDNTKWCAD 1334
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNK-NKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 261245013 1335 WYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEK 1375
Cdd:cd01756    80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 684-805 1.85e-53

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 183.14  E-value: 1.85e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  684 FRYHISVKTGDVSGASTDSRVYIKLYGEKSDTIKQVLLVSDNnlKDYFERGRVDEFTLETLNIGTINRLVIGHDSTGMHA 763
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNN--KNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGA 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 261245013  764 GWFLGSVQIRVPRQGKQYTFPANRWLDKNQADGRLEVELYPS 805
Cdd:cd01756    79 GWFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1680-1800 5.65e-52

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 178.90  E-value: 5.65e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1680 TSYTVSVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFsDMLSLGHLCKLRVWHDNKGIFPG 1759
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNKNKFERGQTDKFTV-EAVDLGKLKKIRIGHDNSGLGAG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 261245013 1760 WHLSYVDVKDNSRDETFRFQCDCWLSKSEGDRQTLRDFACA 1800
Cdd:cd01756    80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 43-162 1.07e-49

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 172.35  E-value: 1.07e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   43 KVYEVVTATGDVRGAGTDANVFITLFGENGLSPKLHL-TSKSESAFEKANVDVFRVRTNNVGLIYKIRIEHDNTGLNASW 121
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLkKSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 261245013  122 YLDRVIVTDMKRpHLRYYFNCNNWLSKVEGDRQWCRDLLAS 162
Cdd:cd01756    81 FLDKVEIREPGT-GDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 816-936 1.18e-49

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 171.97  E-value: 1.18e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  816 YEIEIWTGDVGGAGTTSRVFVQIYGEEGKTEVLFL--SSRSKVFDRGskdifQTDTFTIYAIDLGALTKIRIRHDNTGNR 893
Cdd:cd01756     3 YEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLkkSNNKNKFERG-----QTDKFTVEAVDLGKLKKIRIGHDNSGLG 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 261245013  894 PGWFLDRVDITDVNNETTYYFPCQRWLAVEEDDGQLSRELLPV 936
Cdd:cd01756    78 AGWFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 554-675 2.58e-48

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 168.50  E-value: 2.58e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  554 RYRVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCrNNTDLFEKGNADEFTIESVTMRKVRRVRVRHDGKGSGSGW 633
Cdd:cd01756     2 TYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKS-NNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 261245013  634 YLDRVLVREEGQpeSDNVEFPCLRWLDKDKDDGQLVRELLPS 675
Cdd:cd01756    81 FLDKVEIREPGT--GDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 426-542 1.34e-45

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 160.41  E-value: 1.34e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  426 PWSLWVWTTDLKKAGTNSPIFIQIYGKKGRTDEILLNPNNK--WFKPGIIEKFRMELPDLGRFYKIRAWHDRQNPGSGWH 503
Cdd:cd01756     2 TYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNknKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGWF 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 261245013  504 LEKMTLMNTINKDKYNFNCNRWLDANEDDNEIVREMTAE 542
Cdd:cd01756    82 LDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1101-1227 1.31e-44

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 157.72  E-value: 1.31e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1101 VPYEITLYTSDVFAAGTDANIFIVIYGcDAVCTRQKFLCTNKREQKlfFERKSASRFIVELEDVGEiIEKIRIGHDNTGI 1180
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYG-ENGDTGKRKLKKSNNKNK--FERGQTDKFTVEAVDLGK-LKKIRIGHDNSGL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 261245013 1181 NPGWHCSHVDIRRLLPekdgTETLTFPCDRWLATSEDDKKTIRELVP 1227
Cdd:cd01756    77 GAGWFLDKVEIREPGT----GDEYTFPCNRWLDKDEDDGQIVRELYP 119
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 296-414 1.68e-44

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 157.33  E-value: 1.68e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  296 ITYIVTVFTGDIRGAGTKSKIYLVMYGARGNknSGKIFLE----GGVFDRGRTDIFHIDlAVLLSPLSRVSIGHGNIGVN 371
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGD--TGKRKLKksnnKNKFERGQTDKFTVE-AVDLGKLKKIRIGHDNSGLG 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 261245013  372 RGWYCEKVVILCPFTGIQQTFPCSNWLDEKKADGLIERQLYEM 414
Cdd:cd01756    78 AGWFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1553-1670 7.65e-44

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 155.41  E-value: 7.65e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1553 VLYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEVQLDKK--KARFEREQNDTFIMEILDIAPFTKMRIRIDGMGSRPEW 1630
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSnnKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 261245013 1631 FLERILLKNMNTGDLTMFYYGDWLSQKKGKKTLVCEICAV 1670
Cdd:cd01756    81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT super family cl00011
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1424-1539 2.44e-08

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


The actual alignment was detected with superfamily member cd01752:

Pssm-ID: 412108  Cd Length: 120  Bit Score: 54.20  E-value: 2.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1424 YYVSVTTGKHKEAATDSRAFVLLIGEDDEctnriwldypQGKRGFSCGSVEEFYVGGLDV---------GIIKKIELGHD 1494
Cdd:cd01752     3 YLVTVFTGWRRGAGTTAKVTITLYGAEGE----------SEPHHLRDPEKPIFERGSVDSfllttpfplGELQSIRLWHD 72

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 261245013 1495 GASPESCW-----LVEELclavPTQGTKYTLrCNCWLAKDRGDGVTSRVF 1539
Cdd:cd01752    73 NSGLSPSWylsrvIVRDL----QTGKKWFFL-CNDWLSVEEGDGTVERTF 117
PLAT super family cl00011
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1813-1914 1.43e-04

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


The actual alignment was detected with superfamily member cd00113:

Pssm-ID: 412108  Cd Length: 116  Bit Score: 43.10  E-value: 1.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1813 YEIVIETGN--GGETRENVWLILEGR-KNRSKEFLVENSSRqraFRKGTTDTFEFDsiFLGDIASLCVGHLAREDrfiPK 1889
Cdd:cd00113     3 YTVTIKTGDkkGAGTDSNISLALYGEnGNSSDIPILDGPGS---FERGSTDTFQID--LKLDIGDITKVYLRRDG---SG 74

                          90       100
                  ....*....|....*....|....*
gi 261245013 1890 RELVWHVKTITITEMEYGNVYFFNC 1914
Cdd:cd00113    75 LSDGWYCESITVQALGTKKVYTFPV 99
 
Name Accession Description Interval E-value
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 970-1090 9.07e-57

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 192.38  E-value: 9.07e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  970 TTFSVTIKTGDKKNAGTDANVFITLFGTQDNNGMTLLKSSkTNSDKFERDSIEIFTVETLDLGDLWKVRIGHDNTGKAPG 1049
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKS-NNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 261245013 1050 WFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIVRDLFHA 1090
Cdd:cd01756    80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 172-289 2.00e-55

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 188.53  E-value: 2.00e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  172 NKYEIKVYTGDVIGAGTDADVFINIFGEYGDTGERRLE--NEKDNFEKGAEDKFTLDAPDLGQLMKINVGHNNKGGSAGW 249
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKksNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 261245013  250 FLSKIIIEDIGNKRKYDFPLNRWLALDEDDGKIQRDILVG 289
Cdd:cd01756    81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1949-2067 3.57e-55

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 187.76  E-value: 3.57e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1949 VKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQK-MRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYYSGW 2027
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSnNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 261245013 2028 LVEKVEVTNTSTGVATIFSCGRWLDKSRGDGLTWRELFPS 2067
Cdd:cd01756    81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1255-1375 1.05e-53

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 183.91  E-value: 1.05e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1255 VLYSVQIFTGNVPGAGTDAKVYITIYGDLGDTGERYLGKSENRtNKFEKGTADTFIIEAADLGVIYKIKLRHDNTKWCAD 1334
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNK-NKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 261245013 1335 WYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEK 1375
Cdd:cd01756    80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 684-805 1.85e-53

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 183.14  E-value: 1.85e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  684 FRYHISVKTGDVSGASTDSRVYIKLYGEKSDTIKQVLLVSDNnlKDYFERGRVDEFTLETLNIGTINRLVIGHDSTGMHA 763
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNN--KNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGA 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 261245013  764 GWFLGSVQIRVPRQGKQYTFPANRWLDKNQADGRLEVELYPS 805
Cdd:cd01756    79 GWFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1680-1800 5.65e-52

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 178.90  E-value: 5.65e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1680 TSYTVSVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFsDMLSLGHLCKLRVWHDNKGIFPG 1759
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNKNKFERGQTDKFTV-EAVDLGKLKKIRIGHDNSGLGAG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 261245013 1760 WHLSYVDVKDNSRDETFRFQCDCWLSKSEGDRQTLRDFACA 1800
Cdd:cd01756    80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 43-162 1.07e-49

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 172.35  E-value: 1.07e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   43 KVYEVVTATGDVRGAGTDANVFITLFGENGLSPKLHL-TSKSESAFEKANVDVFRVRTNNVGLIYKIRIEHDNTGLNASW 121
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLkKSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 261245013  122 YLDRVIVTDMKRpHLRYYFNCNNWLSKVEGDRQWCRDLLAS 162
Cdd:cd01756    81 FLDKVEIREPGT-GDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 816-936 1.18e-49

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 171.97  E-value: 1.18e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  816 YEIEIWTGDVGGAGTTSRVFVQIYGEEGKTEVLFL--SSRSKVFDRGskdifQTDTFTIYAIDLGALTKIRIRHDNTGNR 893
Cdd:cd01756     3 YEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLkkSNNKNKFERG-----QTDKFTVEAVDLGKLKKIRIGHDNSGLG 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 261245013  894 PGWFLDRVDITDVNNETTYYFPCQRWLAVEEDDGQLSRELLPV 936
Cdd:cd01756    78 AGWFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 554-675 2.58e-48

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 168.50  E-value: 2.58e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  554 RYRVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCrNNTDLFEKGNADEFTIESVTMRKVRRVRVRHDGKGSGSGW 633
Cdd:cd01756     2 TYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKS-NNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 261245013  634 YLDRVLVREEGQpeSDNVEFPCLRWLDKDKDDGQLVRELLPS 675
Cdd:cd01756    81 FLDKVEIREPGT--GDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 426-542 1.34e-45

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 160.41  E-value: 1.34e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  426 PWSLWVWTTDLKKAGTNSPIFIQIYGKKGRTDEILLNPNNK--WFKPGIIEKFRMELPDLGRFYKIRAWHDRQNPGSGWH 503
Cdd:cd01756     2 TYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNknKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGWF 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 261245013  504 LEKMTLMNTINKDKYNFNCNRWLDANEDDNEIVREMTAE 542
Cdd:cd01756    82 LDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1101-1227 1.31e-44

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 157.72  E-value: 1.31e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1101 VPYEITLYTSDVFAAGTDANIFIVIYGcDAVCTRQKFLCTNKREQKlfFERKSASRFIVELEDVGEiIEKIRIGHDNTGI 1180
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYG-ENGDTGKRKLKKSNNKNK--FERGQTDKFTVEAVDLGK-LKKIRIGHDNSGL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 261245013 1181 NPGWHCSHVDIRRLLPekdgTETLTFPCDRWLATSEDDKKTIRELVP 1227
Cdd:cd01756    77 GAGWFLDKVEIREPGT----GDEYTFPCNRWLDKDEDDGQIVRELYP 119
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 296-414 1.68e-44

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 157.33  E-value: 1.68e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  296 ITYIVTVFTGDIRGAGTKSKIYLVMYGARGNknSGKIFLE----GGVFDRGRTDIFHIDlAVLLSPLSRVSIGHGNIGVN 371
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGD--TGKRKLKksnnKNKFERGQTDKFTVE-AVDLGKLKKIRIGHDNSGLG 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 261245013  372 RGWYCEKVVILCPFTGIQQTFPCSNWLDEKKADGLIERQLYEM 414
Cdd:cd01756    78 AGWFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1553-1670 7.65e-44

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 155.41  E-value: 7.65e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1553 VLYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEVQLDKK--KARFEREQNDTFIMEILDIAPFTKMRIRIDGMGSRPEW 1630
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSnnKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 261245013 1631 FLERILLKNMNTGDLTMFYYGDWLSQKKGKKTLVCEICAV 1670
Cdd:cd01756    81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 174-273 2.37e-20

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 88.26  E-value: 2.37e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   174 YEIKVYTGDVIGAGTDADVFINIFGEYGDTGERRLENEKDNFEKGAEDKFTLDAP-DLGQLMKINVGHNNKGGSAGWFLS 252
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIDTDwDVGAILKINLHWDNNGLSDEWFLK 80

                           90       100
                   ....*....|....*....|..
gi 261245013   253 KIIIEDIG-NKRKYDFPLNRWL 273
Cdd:pfam01477   81 SITVEVPGeTGGKYTFPCNSWV 102
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 298-402 9.70e-20

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 86.72  E-value: 9.70e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   298 YIVTVFTGDIRGAGTKSKIYLVMYGARGNKNSGKIFLEGGVFDRGRTDIFHIDLAVLLSPLSRVSIGHGNIGVNRGWYCE 377
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIDTDWDVGAILKINLHWDNNGLSDEWFLK 80

                           90       100
                   ....*....|....*....|....*.
gi 261245013   378 KVVILCP-FTGIQQTFPCSNWLDEKK 402
Cdd:pfam01477   81 SITVEVPgETGGKYTFPCNSWVYGSK 106
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 972-1079 1.22e-19

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 86.33  E-value: 1.22e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   972 FSVTIKTGDKKNAGTDANVFITLFGTQDNngMTLLKSSKTNSDkFERDSIEIFTVET-LDLGDLWKVRIGHDNTGKAPGW 1050
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGE--SAQLEITLDNPD-FERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEW 77

                           90       100       110
                   ....*....|....*....|....*....|
gi 261245013  1051 FVDWVEVDAPSL-GKCMTFPCGRWLAKNED 1079
Cdd:pfam01477   78 FLKSITVEVPGEtGGKYTFPCNSWVYGSKK 107
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1682-1794 1.35e-19

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 85.95  E-value: 1.35e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  1682 YTVSVKTSDILGAGTDANVFIIIFGENGDSGTLALKQsaNWNKFERNNTDTFNFSDMLSLGHLCKLRVWHDNKGIFPGWH 1761
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITL--DNPDFERGAEDSFEIDTDWDVGAILKINLHWDNNGLSDEWF 78

                           90       100       110
                   ....*....|....*....|....*....|....
gi 261245013  1762 LSYVDVKDNSRDE-TFRFQCDCWLSKSEGDRQTL 1794
Cdd:pfam01477   79 LKSITVEVPGETGgKYTFPCNSWVYGSKKYKETR 112
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 45-148 2.17e-19

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 85.56  E-value: 2.17e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013    45 YEVVTATGDVRGAGTDANVFITLFGENGLSPKLHLTSKSESaFEKANVDVFRVRT-NNVGLIYKIRIEHDNTGLNASWYL 123
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD-FERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEWFL 79

                           90       100
                   ....*....|....*....|....*
gi 261245013   124 DRVIVTDMKRPHLRYYFNCNNWLSK 148
Cdd:pfam01477   80 KSITVEVPGETGGKYTFPCNSWVYG 104
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 816-925 4.16e-19

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 84.79  E-value: 4.16e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   816 YEIEIWTGDVGGAGTTSRVFVQIYGEEGKTEVLFLSSRSKVFDRGSkdifqTDTFTIYA-IDLGALTKIRIRHDNTGNRP 894
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGA-----EDSFEIDTdWDVGAILKINLHWDNNGLSD 75

                           90       100       110
                   ....*....|....*....|....*....|..
gi 261245013   895 GWFLDRVDIT-DVNNETTYYFPCQRWLAVEED 925
Cdd:pfam01477   76 EWFLKSITVEvPGETGGKYTFPCNSWVYGSKK 107
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1951-2060 3.85e-18

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 82.09  E-value: 3.85e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  1951 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKmRNLFERGSTDRFFLET-LELGELRKVRLEHDSSGYYSGWLV 2029
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLD-NPDFERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEWFL 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 261245013  2030 EKVEVT-NTSTGVATIFSCGRWLDKSRGDGLT 2060
Cdd:pfam01477   80 KSITVEvPGETGGKYTFPCNSWVYGSKKYKET 111
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1257-1372 1.02e-17

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 80.94  E-value: 1.02e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  1257 YSVQIFTGNVPGAGTDAKVYITIYGDLGDTGERYLGKSENRtnkFEKGTADTFII-EAADLGVIYKIKLRHDNTKWCADW 1335
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD---FERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDEW 77

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 261245013  1336 YVEKVEIW-NDTNEDEFLFLCGRWLSlKKEDGRLERLF 1372
Cdd:pfam01477   78 FLKSITVEvPGETGGKYTFPCNSWVY-GSKKYKETRVF 114
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 686-793 2.25e-17

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 79.78  E-value: 2.25e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   686 YHISVKTGDVSGASTDSRVYIKLYGEKSDTIKQVLLVSDNNlkdyFERGRVDEFTLET-LNIGTINRLVIGHDSTGMHAG 764
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD----FERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDE 76

                           90       100       110
                   ....*....|....*....|....*....|
gi 261245013   765 WFLGSVQIRVPRQ-GKQYTFPANRWLDKNQ 793
Cdd:pfam01477   77 WFLKSITVEVPGEtGGKYTFPCNSWVYGSK 106
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 427-534 8.04e-16

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 75.55  E-value: 8.04e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   427 WSLWVWTTDLKKAGTNSPIFIQIYGKKGRTDEILLNPNNKWFKPGIIEKFRMELP-DLGRFYKIRAWHDRQNPGSGWHLE 505
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIDTDwDVGAILKINLHWDNNGLSDEWFLK 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 261245013   506 KMTLM-NTINKDKYNFNCNRWLDANEDDNE 534
Cdd:pfam01477   81 SITVEvPGETGGKYTFPCNSWVYGSKKYKE 110
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
173-273 1.83e-14

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 71.13  E-value: 1.83e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013    173 KYEIKVYTGDVIGAGTDADVFINIFGEYGDTGERRL-ENEKDNFEKGAEDKFTLDAP-DLGQLMKINVgHNNKGGSAgWF 250
Cdd:smart00308    2 KYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLdYLFKGIFARGSTYEFTFDVDeDFGELGAVKI-KNEHRHPE-WF 79

                            90       100
                    ....*....|....*....|...
gi 261245013    251 LSKIIIEDIGNKRKYDFPLNRWL 273
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSWV 102
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1103-1221 1.85e-13

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 68.61  E-value: 1.85e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  1103 YEITLYTSDVFAAGTDANIFIVIYGCDAVCTRQKFLCTNKReqklfFERKSASRFIVELE-DVGEIIeKIRIGHDNTGIN 1181
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD-----FERGAEDSFEIDTDwDVGAIL-KINLHWDNNGLS 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 261245013  1182 PGWHCSHVdirRLLPEKDGTETLTFPCDRWLATSEDDKKT 1221
Cdd:pfam01477   75 DEWFLKSI---TVEVPGETGGKYTFPCNSWVYGSKKYKET 111
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1555-1662 5.28e-13

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 67.46  E-value: 5.28e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  1555 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEVQLDKKKARFEREQNDTFIMEI-LDIAPFTKMRIRIDGMGSRPEWFLE 1633
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEWFLK 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 261245013  1634 RILL-KNMNTGDLTMFYYGDWLSQKKGKKT 1662
Cdd:pfam01477   81 SITVeVPGETGGKYTFPCNSWVYGSKKYKE 110
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 555-664 6.17e-13

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 67.07  E-value: 6.17e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   555 YRVTVCTGELEGAGTDANVYLCLFGDVGDTGerLLYNCRNNTDlFEKGNADEFTI-ESVTMRKVRRVRVRHDGKGSGSGW 633
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESA--QLEITLDNPD-FERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDEW 77

                           90       100       110
                   ....*....|....*....|....*....|.
gi 261245013   634 YLDRVLVREEGQPESdNVEFPCLRWLDKDKD 664
Cdd:pfam01477   78 FLKSITVEVPGETGG-KYTFPCNSWVYGSKK 107
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
974-1077 6.56e-13

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 66.51  E-value: 6.56e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013    974 VTIKTGDKKNAGTDANVFITLFGTQDNNGMTLLKSSKTNSdkFERDSIEIFTVET-LDLGDLWKVRIGHDNtgKAPGWFV 1052
Cdd:smart00308    5 VTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGI--FARGSTYEFTFDVdEDFGELGAVKIKNEH--RHPEWFL 80

                            90       100
                    ....*....|....*....|....*
gi 261245013   1053 DWVEVDAPSLGKCMTFPCGRWLAKN 1077
Cdd:smart00308   81 KSITVKDLPTGGKYHFPCNSWVYPD 105
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
815-920 6.63e-13

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 66.51  E-value: 6.63e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013    815 HYEIEIWTGDVGGAGTTSRVFVQIYGEEGKTEVLFLSSRSKV-FDRGSKDIFQTDTFTiyaiDLGALTKIRIRHDNtgNR 893
Cdd:smart00308    2 KYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGiFARGSTYEFTFDVDE----DFGELGAVKIKNEH--RH 75

                            90       100
                    ....*....|....*....|....*..
gi 261245013    894 PGWFLDRVDITDVNNETTYYFPCQRWL 920
Cdd:smart00308   76 PEWFLKSITVKDLPTGGKYHFPCNSWV 102
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1950-2053 1.37e-12

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 65.74  E-value: 1.37e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   1950 KYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET-LELGELRKVRLEHDssGYYSGWL 2028
Cdd:smart00308    2 KYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGIFARGSTYEFTFDVdEDFGELGAVKIKNE--HRHPEWF 79

                            90       100
                    ....*....|....*....|....*
gi 261245013   2029 VEKVEVTNTSTGVATIFSCGRWLDK 2053
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSWVYP 104
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
431-527 1.06e-10

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 60.35  E-value: 1.06e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013    431 VWTTDLKKAGTNSPIFIQIYGKKGRTDEILLNPNNKW-FKPGIIEKFRMELP-DLGRFYKIRAWHdrQNPGSGWHLEKMT 508
Cdd:smart00308    7 VTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGiFARGSTYEFTFDVDeDFGELGAVKIKN--EHRHPEWFLKSIT 84

                            90
                    ....*....|....*....
gi 261245013    509 LMNTINKDKYNFNCNRWLD 527
Cdd:smart00308   85 VKDLPTGGKYHFPCNSWVY 103
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
684-792 4.33e-09

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 55.73  E-value: 4.33e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013    684 FRYHISVKTGDVSGASTDSRVYIKLYGEKSDTIKQVLlvsDNNLKDYFERGRVDEFTLET-LNIGTINRLVIGHDSTgmH 762
Cdd:smart00308    1 GKYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKL---DYLFKGIFARGSTYEFTFDVdEDFGELGAVKIKNEHR--H 75

                            90       100       110
                    ....*....|....*....|....*....|
gi 261245013    763 AGWFLGSVQIRVPRQGKQYTFPANRWLDKN 792
Cdd:smart00308   76 PEWFLKSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 1424-1539 2.44e-08

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 54.20  E-value: 2.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1424 YYVSVTTGKHKEAATDSRAFVLLIGEDDEctnriwldypQGKRGFSCGSVEEFYVGGLDV---------GIIKKIELGHD 1494
Cdd:cd01752     3 YLVTVFTGWRRGAGTTAKVTITLYGAEGE----------SEPHHLRDPEKPIFERGSVDSfllttpfplGELQSIRLWHD 72

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 261245013 1495 GASPESCW-----LVEELclavPTQGTKYTLrCNCWLAKDRGDGVTSRVF 1539
Cdd:cd01752    73 NSGLSPSWylsrvIVRDL----QTGKKWFFL-CNDWLSVEEGDGTVERTF 117
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
298-401 2.72e-08

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 53.41  E-value: 2.72e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013    298 YIVTVFTGDIRGAGTKSKIYLVMYGARG-NKNSGKIFLEGGVFDRGRTDIFHIDLAVLLSPLSRVSIGHGNIGvnRGWYC 376
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGdGKESKLDYLFKGIFARGSTYEFTFDVDEDFGELGAVKIKNEHRH--PEWFL 80

                            90       100
                    ....*....|....*....|....*
gi 261245013    377 EKVVILCPFTGIQQTFPCSNWLDEK 401
Cdd:smart00308   81 KSITVKDLPTGGKYHFPCNSWVYPD 105
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1682-1786 3.34e-08

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 53.41  E-value: 3.34e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   1682 YTVSVKTSDILGAGTDANVFIIIFGENGDSGtLALKQSANWNKFERNNTDTFNFSDMLSLGHLCKLRVWHDNKgiFPGWH 1761
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGK-ESKLDYLFKGIFARGSTYEFTFDVDEDFGELGAVKIKNEHR--HPEWF 79

                            90       100
                    ....*....|....*....|....*
gi 261245013   1762 LSYVDVKDNSRDETFRFQCDCWLSK 1786
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSWVYP 104
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1424-1539 3.92e-08

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 53.59  E-value: 3.92e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  1424 YYVSVTTGKHKEAATDSRAFVLLIGEDDECTNR-IWLDYPqgkrGFSCGSVEEFYV-GGLDVGIIKKIELGHDGASPESC 1501
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLeITLDNP----DFERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDE 76

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 261245013  1502 WLVEELCLAVP-TQGTKYTLRCNCWLAKDRGDGVTsRVF 1539
Cdd:pfam01477   77 WFLKSITVEVPgETGGKYTFPCNSWVYGSKKYKET-RVF 114
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
553-662 9.75e-08

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 51.87  E-value: 9.75e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013    553 ARYRVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNtdLFEKGNADEFTIESVTMRKVRRVRVRHDGKGSgSG 632
Cdd:smart00308    1 GKYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKG--IFARGSTYEFTFDVDEDFGELGAVKIKNEHRH-PE 77

                            90       100       110
                    ....*....|....*....|....*....|
gi 261245013    633 WYLDRVLVreEGQPESDNVEFPCLRWLDKD 662
Cdd:smart00308   78 WFLKSITV--KDLPTGGKYHFPCNSWVYPD 105
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1257-1362 1.10e-07

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 51.87  E-value: 1.10e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   1257 YSVQIFTGNVPGAGTDAKVYITIYGDLGDTGERYLGKSENrtNKFEKGTADTFIIE-AADLGVIYKIKLRHDNTKwcADW 1335
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFK--GIFARGSTYEFTFDvDEDFGELGAVKIKNEHRH--PEW 78

                            90       100
                    ....*....|....*....|....*..
gi 261245013   1336 YVEKVEIWNDTNEDEFLFLCGRWLSLK 1362
Cdd:smart00308   79 FLKSITVKDLPTGGKYHFPCNSWVYPD 105
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
45-148 1.54e-07

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 51.49  E-value: 1.54e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013     45 YEVVTATGDVRGAGTDANVFITLFGENGLSPKLHLTSKSESAFEKANVDVFRVRTN-NVGLIYKIRIEHDNTGlnASWYL 123
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGIFARGSTYEFTFDVDeDFGELGAVKIKNEHRH--PEWFL 80

                            90       100
                    ....*....|....*....|....*
gi 261245013    124 DRVIVTDMKrPHLRYYFNCNNWLSK 148
Cdd:smart00308   81 KSITVKDLP-TGGKYHFPCNSWVYP 104
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1555-1655 1.18e-05

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 46.10  E-value: 1.18e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   1555 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEVQLDK-KKARFEREQNDTFIMEI-LDIAPFTKMRIRIDgmGSRPEWFL 1632
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYlFKGIFARGSTYEFTFDVdEDFGELGAVKIKNE--HRHPEWFL 80

                            90       100
                    ....*....|....*....|...
gi 261245013   1633 ERILLKNMNTGDLTMFYYGDWLS 1655
Cdd:smart00308   81 KSITVKDLPTGGKYHFPCNSWVY 103
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1424-1529 3.54e-05

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 44.55  E-value: 3.54e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   1424 YYVSVTTGKHKEAATDSRAFVLLIGEDDECTNRIwlDYPQGKRGFSCGSVEEFYV-GGLDVGIIKKIELGHDGASPEscW 1502
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESK--LDYLFKGIFARGSTYEFTFdVDEDFGELGAVKIKNEHRHPE--W 78

                            90       100
                    ....*....|....*....|....*..
gi 261245013   1503 LVEELCLAVPTQGTKYTLRCNCWLAKD 1529
Cdd:smart00308   79 FLKSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1813-1914 1.43e-04

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 43.10  E-value: 1.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1813 YEIVIETGN--GGETRENVWLILEGR-KNRSKEFLVENSSRqraFRKGTTDTFEFDsiFLGDIASLCVGHLAREDrfiPK 1889
Cdd:cd00113     3 YTVTIKTGDkkGAGTDSNISLALYGEnGNSSDIPILDGPGS---FERGSTDTFQID--LKLDIGDITKVYLRRDG---SG 74

                          90       100
                  ....*....|....*....|....*
gi 261245013 1890 RELVWHVKTITITEMEYGNVYFFNC 1914
Cdd:cd00113    75 LSDGWYCESITVQALGTKKVYTFPV 99
 
Name Accession Description Interval E-value
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 970-1090 9.07e-57

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 192.38  E-value: 9.07e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  970 TTFSVTIKTGDKKNAGTDANVFITLFGTQDNNGMTLLKSSkTNSDKFERDSIEIFTVETLDLGDLWKVRIGHDNTGKAPG 1049
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKS-NNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 261245013 1050 WFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIVRDLFHA 1090
Cdd:cd01756    80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 172-289 2.00e-55

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 188.53  E-value: 2.00e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  172 NKYEIKVYTGDVIGAGTDADVFINIFGEYGDTGERRLE--NEKDNFEKGAEDKFTLDAPDLGQLMKINVGHNNKGGSAGW 249
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKksNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 261245013  250 FLSKIIIEDIGNKRKYDFPLNRWLALDEDDGKIQRDILVG 289
Cdd:cd01756    81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1949-2067 3.57e-55

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 187.76  E-value: 3.57e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1949 VKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQK-MRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYYSGW 2027
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSnNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 261245013 2028 LVEKVEVTNTSTGVATIFSCGRWLDKSRGDGLTWRELFPS 2067
Cdd:cd01756    81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1255-1375 1.05e-53

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 183.91  E-value: 1.05e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1255 VLYSVQIFTGNVPGAGTDAKVYITIYGDLGDTGERYLGKSENRtNKFEKGTADTFIIEAADLGVIYKIKLRHDNTKWCAD 1334
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNK-NKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 261245013 1335 WYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEK 1375
Cdd:cd01756    80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 684-805 1.85e-53

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 183.14  E-value: 1.85e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  684 FRYHISVKTGDVSGASTDSRVYIKLYGEKSDTIKQVLLVSDNnlKDYFERGRVDEFTLETLNIGTINRLVIGHDSTGMHA 763
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNN--KNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGA 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 261245013  764 GWFLGSVQIRVPRQGKQYTFPANRWLDKNQADGRLEVELYPS 805
Cdd:cd01756    79 GWFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1680-1800 5.65e-52

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 178.90  E-value: 5.65e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1680 TSYTVSVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFsDMLSLGHLCKLRVWHDNKGIFPG 1759
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNKNKFERGQTDKFTV-EAVDLGKLKKIRIGHDNSGLGAG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 261245013 1760 WHLSYVDVKDNSRDETFRFQCDCWLSKSEGDRQTLRDFACA 1800
Cdd:cd01756    80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 43-162 1.07e-49

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 172.35  E-value: 1.07e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   43 KVYEVVTATGDVRGAGTDANVFITLFGENGLSPKLHL-TSKSESAFEKANVDVFRVRTNNVGLIYKIRIEHDNTGLNASW 121
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLkKSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 261245013  122 YLDRVIVTDMKRpHLRYYFNCNNWLSKVEGDRQWCRDLLAS 162
Cdd:cd01756    81 FLDKVEIREPGT-GDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 816-936 1.18e-49

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 171.97  E-value: 1.18e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  816 YEIEIWTGDVGGAGTTSRVFVQIYGEEGKTEVLFL--SSRSKVFDRGskdifQTDTFTIYAIDLGALTKIRIRHDNTGNR 893
Cdd:cd01756     3 YEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLkkSNNKNKFERG-----QTDKFTVEAVDLGKLKKIRIGHDNSGLG 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 261245013  894 PGWFLDRVDITDVNNETTYYFPCQRWLAVEEDDGQLSRELLPV 936
Cdd:cd01756    78 AGWFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 554-675 2.58e-48

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 168.50  E-value: 2.58e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  554 RYRVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCrNNTDLFEKGNADEFTIESVTMRKVRRVRVRHDGKGSGSGW 633
Cdd:cd01756     2 TYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKS-NNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 261245013  634 YLDRVLVREEGQpeSDNVEFPCLRWLDKDKDDGQLVRELLPS 675
Cdd:cd01756    81 FLDKVEIREPGT--GDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 426-542 1.34e-45

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 160.41  E-value: 1.34e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  426 PWSLWVWTTDLKKAGTNSPIFIQIYGKKGRTDEILLNPNNK--WFKPGIIEKFRMELPDLGRFYKIRAWHDRQNPGSGWH 503
Cdd:cd01756     2 TYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNknKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGWF 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 261245013  504 LEKMTLMNTINKDKYNFNCNRWLDANEDDNEIVREMTAE 542
Cdd:cd01756    82 LDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1101-1227 1.31e-44

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 157.72  E-value: 1.31e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1101 VPYEITLYTSDVFAAGTDANIFIVIYGcDAVCTRQKFLCTNKREQKlfFERKSASRFIVELEDVGEiIEKIRIGHDNTGI 1180
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYG-ENGDTGKRKLKKSNNKNK--FERGQTDKFTVEAVDLGK-LKKIRIGHDNSGL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 261245013 1181 NPGWHCSHVDIRRLLPekdgTETLTFPCDRWLATSEDDKKTIRELVP 1227
Cdd:cd01756    77 GAGWFLDKVEIREPGT----GDEYTFPCNRWLDKDEDDGQIVRELYP 119
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 296-414 1.68e-44

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 157.33  E-value: 1.68e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  296 ITYIVTVFTGDIRGAGTKSKIYLVMYGARGNknSGKIFLE----GGVFDRGRTDIFHIDlAVLLSPLSRVSIGHGNIGVN 371
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGD--TGKRKLKksnnKNKFERGQTDKFTVE-AVDLGKLKKIRIGHDNSGLG 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 261245013  372 RGWYCEKVVILCPFTGIQQTFPCSNWLDEKKADGLIERQLYEM 414
Cdd:cd01756    78 AGWFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1553-1670 7.65e-44

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 155.41  E-value: 7.65e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1553 VLYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEVQLDKK--KARFEREQNDTFIMEILDIAPFTKMRIRIDGMGSRPEW 1630
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSnnKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 261245013 1631 FLERILLKNMNTGDLTMFYYGDWLSQKKGKKTLVCEICAV 1670
Cdd:cd01756    81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 815-934 1.08e-34

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 129.32  E-value: 1.08e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  815 HYEIEIWTGDVGGAGTTSRVFVQIYGEEGKTEV-LFLSSRSKVFDRGSKDIFQTDTftiyAIDLGALTKIRIRHDNTGNR 893
Cdd:cd01752     2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPhHLRDPEKPIFERGSVDSFLLTT----PFPLGELQSIRLWHDNSGLS 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 261245013  894 PGWFLDRVDITDVNNETTYYFPCQRWLAVEEDDGQLSRELL 934
Cdd:cd01752    78 PSWYLSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFP 118
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 173-288 5.61e-30

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 115.84  E-value: 5.61e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  173 KYEIKVYTGDVIGAGTDADVFINIFGEYGDTGERRLENEKDN-FEKGAEDKFTLDAP-DLGQLMKINVGHNNKGGSAGWF 250
Cdd:cd01752     2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPEKPiFERGSVDSFLLTTPfPLGELQSIRLWHDNSGLSPSWY 81

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 261245013  251 LSKIIIEDIGNKRKYDFPLNRWLALDEDDGKIQRDILV 288
Cdd:cd01752    82 LSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFPV 119
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1555-1665 2.52e-29

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 113.97  E-value: 2.52e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1555 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEVQLDKKKARFEREQNDTFIMEI-LDIAPFTKMRIRIDGMGSRPEWFLE 1633
Cdd:cd00113     3 YTVTIKTGDKKGAGTDSNISLALYGENGNSSDIPILDGPGSFERGSTDTFQIDLkLDIGDITKVYLRRDGSGLSDGWYCE 82

                          90       100       110
                  ....*....|....*....|....*....|..
gi 261245013 1634 RILLKNMNTGDLTMFYYGDWLSQKKGKKTLVC 1665
Cdd:cd00113    83 SITVQALGTKKVYTFPVNRWVLGGKWYTSVRS 114
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 45-154 4.88e-29

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 113.14  E-value: 4.88e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   45 YEVVTATGDVRGAGTDANVFITLFGENGLSPKLHLTSKSESAFEKANVDVFRVRT-NNVGLIYKIRIEHDNTGLNASWYL 123
Cdd:cd01752     3 YLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPEKPIFERGSVDSFLLTTpFPLGELQSIRLWHDNSGLSPSWYL 82

                          90       100       110
                  ....*....|....*....|....*....|.
gi 261245013  124 DRVIVTDMKRPHlRYYFNCNNWLSKVEGDRQ 154
Cdd:cd01752    83 SRVIVRDLQTGK-KWFFLCNDWLSVEEGDGT 112
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 1950-2065 9.82e-29

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 112.37  E-value: 9.82e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1950 KYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLETLE-LGELRKVRLEHDSSGYYSGWL 2028
Cdd:cd01752     2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPEKPIFERGSVDSFLLTTPFpLGELQSIRLWHDNSGLSPSWY 81

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 261245013 2029 VEKVEVTNTSTGVATIFSCGRWLDKSRGDGLTWRELF 2065
Cdd:cd01752    82 LSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFP 118
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 1681-1800 9.24e-28

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 109.67  E-value: 9.24e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1681 SYTVSVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSaNWNKFERNNTDTFNFSDMLSLGHLCKLRVWHDNKGIFPGW 1760
Cdd:cd01752     2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDP-EKPIFERGSVDSFLLTTPFPLGELQSIRLWHDNSGLSPSW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 261245013 1761 HLSYVDVKDNSRDETFRFQCDCWLSKSEGDRQTLRDFACA 1800
Cdd:cd01752    81 YLSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFPVA 120
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 1256-1373 4.28e-27

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 107.75  E-value: 4.28e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1256 LYSVQIFTGNVPGAGTDAKVYITIYGDLGDTGERYLGKSENRTnkFEKGTADTFIIEAA-DLGVIYKIKLRHDNTKWCAD 1334
Cdd:cd01752     2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPEKPI--FERGSVDSFLLTTPfPLGELQSIRLWHDNSGLSPS 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 261245013 1335 WYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFY 1373
Cdd:cd01752    80 WYLSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFP 118
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 974-1090 1.54e-22

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 94.65  E-value: 1.54e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  974 VTIKTGDKKNAGTDANVFITLFGtqdNNGMTLLKS-SKTNSDKFERDSIEIFTVETL-DLGDLWKVRIGHDNTGKAPGWF 1051
Cdd:cd01752     5 VTVFTGWRRGAGTTAKVTITLYG---AEGESEPHHlRDPEKPIFERGSVDSFLLTTPfPLGELQSIRLWHDNSGLSPSWY 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 261245013 1052 VDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIVRDLFHA 1090
Cdd:cd01752    82 LSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFPVA 120
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 972-1082 2.26e-22

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 93.94  E-value: 2.26e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  972 FSVTIKTGDKKNAGTDANVFITLFGTqdnNGMTLLKSSKTNSDKFERDSIEIFTVET-LDLGDLWKVRIGHDNTGKAPGW 1050
Cdd:cd00113     3 YTVTIKTGDKKGAGTDSNISLALYGE---NGNSSDIPILDGPGSFERGSTDTFQIDLkLDIGDITKVYLRRDGSGLSDGW 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 261245013 1051 FVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGS 1082
Cdd:cd00113    80 YCESITVQALGTKKVYTFPVNRWVLGGKWYTS 111
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 815-920 7.37e-21

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 89.71  E-value: 7.37e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  815 HYEIEIWTGDVGGAGTTSRVFVQIYGEEGKTEVLFLSSRSKVFDRGSkdifqTDTFTIYA-IDLGALTKIRIRHDNTGNR 893
Cdd:cd00113     2 RYTVTIKTGDKKGAGTDSNISLALYGENGNSSDIPILDGPGSFERGS-----TDTFQIDLkLDIGDITKVYLRRDGSGLS 76

                          90       100
                  ....*....|....*....|....*..
gi 261245013  894 PGWFLDRVDITDVNNETTYYFPCQRWL 920
Cdd:cd00113    77 DGWYCESITVQALGTKKVYTFPVNRWV 103
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 174-273 2.37e-20

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 88.26  E-value: 2.37e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   174 YEIKVYTGDVIGAGTDADVFINIFGEYGDTGERRLENEKDNFEKGAEDKFTLDAP-DLGQLMKINVGHNNKGGSAGWFLS 252
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIDTDwDVGAILKINLHWDNNGLSDEWFLK 80

                           90       100
                   ....*....|....*....|..
gi 261245013   253 KIIIEDIG-NKRKYDFPLNRWL 273
Cdd:pfam01477   81 SITVEVPGeTGGKYTFPCNSWV 102
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1682-1793 3.01e-20

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 88.16  E-value: 3.01e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1682 YTVSVKTSDILGAGTDANVFIIIFGENGDSGTLalKQSANWNKFERNNTDTFNFSDMLSLGHLCKLRVWHDNKGIFPGWH 1761
Cdd:cd00113     3 YTVTIKTGDKKGAGTDSNISLALYGENGNSSDI--PILDGPGSFERGSTDTFQIDLKLDIGDITKVYLRRDGSGLSDGWY 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 261245013 1762 LSYVDVKDNSRDETFRFQCDCWLSKSEGDRQT 1793
Cdd:cd00113    81 CESITVQALGTKKVYTFPVNRWVLGGKWYTSV 112
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 684-803 3.47e-20

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 88.10  E-value: 3.47e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  684 FRYHISVKTGDVSGASTDSRVYIKLYGEKSDTIKQVLLVSDnnlKDYFERGRVDEFTLETL-NIGTINRLVIGHDSTGMH 762
Cdd:cd01752     1 YLYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPE---KPIFERGSVDSFLLTTPfPLGELQSIRLWHDNSGLS 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 261245013  763 AGWFLGSVQIRVPRQGKQYTFPANRWLDKNQADGRLEVELY 803
Cdd:cd01752    78 PSWYLSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFP 118
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 298-402 9.70e-20

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 86.72  E-value: 9.70e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   298 YIVTVFTGDIRGAGTKSKIYLVMYGARGNKNSGKIFLEGGVFDRGRTDIFHIDLAVLLSPLSRVSIGHGNIGVNRGWYCE 377
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIDTDWDVGAILKINLHWDNNGLSDEWFLK 80

                           90       100
                   ....*....|....*....|....*.
gi 261245013   378 KVVILCP-FTGIQQTFPCSNWLDEKK 402
Cdd:pfam01477   81 SITVEVPgETGGKYTFPCNSWVYGSK 106
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 972-1079 1.22e-19

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 86.33  E-value: 1.22e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   972 FSVTIKTGDKKNAGTDANVFITLFGTQDNngMTLLKSSKTNSDkFERDSIEIFTVET-LDLGDLWKVRIGHDNTGKAPGW 1050
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGE--SAQLEITLDNPD-FERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEW 77

                           90       100       110
                   ....*....|....*....|....*....|
gi 261245013  1051 FVDWVEVDAPSL-GKCMTFPCGRWLAKNED 1079
Cdd:pfam01477   78 FLKSITVEVPGEtGGKYTFPCNSWVYGSKK 107
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1682-1794 1.35e-19

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 85.95  E-value: 1.35e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  1682 YTVSVKTSDILGAGTDANVFIIIFGENGDSGTLALKQsaNWNKFERNNTDTFNFSDMLSLGHLCKLRVWHDNKGIFPGWH 1761
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITL--DNPDFERGAEDSFEIDTDWDVGAILKINLHWDNNGLSDEWF 78

                           90       100       110
                   ....*....|....*....|....*....|....
gi 261245013  1762 LSYVDVKDNSRDE-TFRFQCDCWLSKSEGDRQTL 1794
Cdd:pfam01477   79 LKSITVEVPGETGgKYTFPCNSWVYGSKKYKETR 112
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 45-148 2.17e-19

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 85.56  E-value: 2.17e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013    45 YEVVTATGDVRGAGTDANVFITLFGENGLSPKLHLTSKSESaFEKANVDVFRVRT-NNVGLIYKIRIEHDNTGLNASWYL 123
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD-FERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEWFL 79

                           90       100
                   ....*....|....*....|....*
gi 261245013   124 DRVIVTDMKRPHLRYYFNCNNWLSK 148
Cdd:pfam01477   80 KSITVEVPGETGGKYTFPCNSWVYG 104
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 816-925 4.16e-19

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 84.79  E-value: 4.16e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   816 YEIEIWTGDVGGAGTTSRVFVQIYGEEGKTEVLFLSSRSKVFDRGSkdifqTDTFTIYA-IDLGALTKIRIRHDNTGNRP 894
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGA-----EDSFEIDTdWDVGAILKINLHWDNNGLSD 75

                           90       100       110
                   ....*....|....*....|....*....|..
gi 261245013   895 GWFLDRVDIT-DVNNETTYYFPCQRWLAVEED 925
Cdd:pfam01477   76 EWFLKSITVEvPGETGGKYTFPCNSWVYGSKK 107
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 173-280 6.87e-19

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 84.31  E-value: 6.87e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  173 KYEIKVYTGDVIGAGTDADVFINIFGEYGDTGERRLENEKDNFEKGAEDKFTLDAP-DLGQLMKINVGHNNKGGSAGWFL 251
Cdd:cd00113     2 RYTVTIKTGDKKGAGTDSNISLALYGENGNSSDIPILDGPGSFERGSTDTFQIDLKlDIGDITKVYLRRDGSGLSDGWYC 81

                          90       100
                  ....*....|....*....|....*....
gi 261245013  252 SKIIIEDIGNKRKYDFPLNRWLALDEDDG 280
Cdd:cd00113    82 ESITVQALGTKKVYTFPVNRWVLGGKWYT 110
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1950-2060 1.16e-18

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 83.54  E-value: 1.16e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1950 KYEVIVTTGYEPGAGTDANVFVTIFGANGdtgKRELKQKMRNL--FERGSTDRFFLET-LELGELRKVRLEHDSSGYYSG 2026
Cdd:cd00113     2 RYTVTIKTGDKKGAGTDSNISLALYGENG---NSSDIPILDGPgsFERGSTDTFQIDLkLDIGDITKVYLRRDGSGLSDG 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 261245013 2027 WLVEKVEVTNTSTGVATIFSCGRWLDKSRGDGLT 2060
Cdd:cd00113    79 WYCESITVQALGTKKVYTFPVNRWVLGGKWYTSV 112
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 43-148 1.19e-18

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 83.54  E-value: 1.19e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   43 KVYEVVTATGDVRGAGTDANVFITLFGENGLSPKLHLTSKSESaFEKANVDVFRVRT-NNVGLIYKIRIEHDNTGLNASW 121
Cdd:cd00113     1 CRYTVTIKTGDKKGAGTDSNISLALYGENGNSSDIPILDGPGS-FERGSTDTFQIDLkLDIGDITKVYLRRDGSGLSDGW 79

                          90       100
                  ....*....|....*....|....*..
gi 261245013  122 YLDRVIVTDMKRPHlRYYFNCNNWLSK 148
Cdd:cd00113    80 YCESITVQALGTKK-VYTFPVNRWVLG 105
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 1103-1225 1.41e-18

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 83.48  E-value: 1.41e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1103 YEITLYTSDVFAAGTDANIFIVIYGCDAVCTRQKFLCTNKReqklFFERKSASRFIVE-LEDVGEIiEKIRIGHDNTGIN 1181
Cdd:cd01752     3 YLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPEKP----IFERGSVDSFLLTtPFPLGEL-QSIRLWHDNSGLS 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 261245013 1182 PGWHCSHVDIRRLLPEKdgteTLTFPCDRWLATSEDDKKTIREL 1225
Cdd:cd01752    78 PSWYLSRVIVRDLQTGK----KWFFLCNDWLSVEEGDGTVERTF 117
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1951-2060 3.85e-18

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 82.09  E-value: 3.85e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  1951 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKmRNLFERGSTDRFFLET-LELGELRKVRLEHDSSGYYSGWLV 2029
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLD-NPDFERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEWFL 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 261245013  2030 EKVEVT-NTSTGVATIFSCGRWLDKSRGDGLT 2060
Cdd:pfam01477   80 KSITVEvPGETGGKYTFPCNSWVYGSKKYKET 111
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 298-400 6.66e-18

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 81.23  E-value: 6.66e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  298 YIVTVFTGDIRGAGTKSKIYLVMYGARGNKNSGKIFLEGGVFDRGRTDIFHIDLAVLLSPLSRVSIGHGNIGVNRGWYCE 377
Cdd:cd00113     3 YTVTIKTGDKKGAGTDSNISLALYGENGNSSDIPILDGPGSFERGSTDTFQIDLKLDIGDITKVYLRRDGSGLSDGWYCE 82

                          90       100
                  ....*....|....*....|...
gi 261245013  378 KVVILCPFTGIQQTFPCSNWLDE 400
Cdd:cd00113    83 SITVQALGTKKVYTFPVNRWVLG 105
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1257-1372 1.02e-17

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 80.94  E-value: 1.02e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  1257 YSVQIFTGNVPGAGTDAKVYITIYGDLGDTGERYLGKSENRtnkFEKGTADTFII-EAADLGVIYKIKLRHDNTKWCADW 1335
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD---FERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDEW 77

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 261245013  1336 YVEKVEIW-NDTNEDEFLFLCGRWLSlKKEDGRLERLF 1372
Cdd:pfam01477   78 FLKSITVEvPGETGGKYTFPCNSWVY-GSKKYKETRVF 114
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 686-793 2.25e-17

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 79.78  E-value: 2.25e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   686 YHISVKTGDVSGASTDSRVYIKLYGEKSDTIKQVLLVSDNNlkdyFERGRVDEFTLET-LNIGTINRLVIGHDSTGMHAG 764
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD----FERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDE 76

                           90       100       110
                   ....*....|....*....|....*....|
gi 261245013   765 WFLGSVQIRVPRQ-GKQYTFPANRWLDKNQ 793
Cdd:pfam01477   77 WFLKSITVEVPGEtGGKYTFPCNSWVYGSK 106
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 685-792 8.49e-17

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 78.15  E-value: 8.49e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  685 RYHISVKTGDVSGASTDSRVYIKLYGEKSDTiKQVLLVSDNnlkDYFERGRVDEFTLET-LNIGTINRLVIGHDSTGMHA 763
Cdd:cd00113     2 RYTVTIKTGDKKGAGTDSNISLALYGENGNS-SDIPILDGP---GSFERGSTDTFQIDLkLDIGDITKVYLRRDGSGLSD 77

                          90       100
                  ....*....|....*....|....*....
gi 261245013  764 GWFLGSVQIRVPRQGKQYTFPANRWLDKN 792
Cdd:cd00113    78 GWYCESITVQALGTKKVYTFPVNRWVLGG 106
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 298-412 1.37e-16

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 77.70  E-value: 1.37e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  298 YIVTVFTGDIRGAGTKSKIYLVMYGArgNKNSGKIFLEGG---VFDRGRTDIFHIDLAVLLSPLSRVSIGHGNIGVNRGW 374
Cdd:cd01752     3 YLVTVFTGWRRGAGTTAKVTITLYGA--EGESEPHHLRDPekpIFERGSVDSFLLTTPFPLGELQSIRLWHDNSGLSPSW 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 261245013  375 YCEKVVILCPFTGIQQTFPCSNWLDEKKADGLIERQLY 412
Cdd:cd01752    81 YLSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFP 118
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 425-533 2.03e-16

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 76.99  E-value: 2.03e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  425 YPWSLWVWTTDLKKAGTNSPIFIQIYGKKGRTDEILLNPNNKWFKPGIIEKFRMELP-DLGRFYKIRAWHDRQNPGSGWH 503
Cdd:cd00113     1 CRYTVTIKTGDKKGAGTDSNISLALYGENGNSSDIPILDGPGSFERGSTDTFQIDLKlDIGDITKVYLRRDGSGLSDGWY 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 261245013  504 LEKMTLMNTINKDKYNFNCNRWLDANEDDN 533
Cdd:cd00113    81 CESITVQALGTKKVYTFPVNRWVLGGKWYT 110
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 427-534 8.04e-16

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 75.55  E-value: 8.04e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   427 WSLWVWTTDLKKAGTNSPIFIQIYGKKGRTDEILLNPNNKWFKPGIIEKFRMELP-DLGRFYKIRAWHDRQNPGSGWHLE 505
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIDTDwDVGAILKINLHWDNNGLSDEWFLK 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 261245013   506 KMTLM-NTINKDKYNFNCNRWLDANEDDNE 534
Cdd:pfam01477   81 SITVEvPGETGGKYTFPCNSWVYGSKKYKE 110
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1257-1372 1.18e-15

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 75.07  E-value: 1.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1257 YSVQIFTGNVPGAGTDAKVYITIYGDLGDTGErylGKSENRTNKFEKGTADTFIIEAA-DLGVIYKIKLRHDNTKWCADW 1335
Cdd:cd00113     3 YTVTIKTGDKKGAGTDSNISLALYGENGNSSD---IPILDGPGSFERGSTDTFQIDLKlDIGDITKVYLRRDGSGLSDGW 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 261245013 1336 YVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLF 1372
Cdd:cd00113    80 YCESITVQALGTKKVYTFPVNRWVLGGKWYTSVRSLK 116
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 1554-1669 1.45e-15

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 74.62  E-value: 1.45e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1554 LYEMTVWTGDVVGGGTDSNIFMTLYGINGSTE-EVQLDKKKARFEREQNDTFIMEildiAPF-----TKMRIRIDGMGSR 1627
Cdd:cd01752     2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEpHHLRDPEKPIFERGSVDSFLLT----TPFplgelQSIRLWHDNSGLS 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 261245013 1628 PEWFLERILLKNMNTGDLTMFYYGDWLSQKKGKKTLVCEICA 1669
Cdd:cd01752    78 PSWYLSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFPV 119
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
173-273 1.83e-14

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 71.13  E-value: 1.83e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013    173 KYEIKVYTGDVIGAGTDADVFINIFGEYGDTGERRL-ENEKDNFEKGAEDKFTLDAP-DLGQLMKINVgHNNKGGSAgWF 250
Cdd:smart00308    2 KYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLdYLFKGIFARGSTYEFTFDVDeDFGELGAVKI-KNEHRHPE-WF 79

                            90       100
                    ....*....|....*....|...
gi 261245013    251 LSKIIIEDIGNKRKYDFPLNRWL 273
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSWV 102
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 437-542 4.72e-14

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 70.38  E-value: 4.72e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  437 KKAGTNSPIFIQIYGKKGRTD-EILLNPNNKWFKPGIIEKFRMELP-DLGRFYKIRAWHDRQNPGSGWHLEKMTLMNTIN 514
Cdd:cd01752    13 RGAGTTAKVTITLYGAEGESEpHHLRDPEKPIFERGSVDSFLLTTPfPLGELQSIRLWHDNSGLSPSWYLSRVIVRDLQT 92

                          90       100
                  ....*....|....*....|....*...
gi 261245013  515 KDKYNFNCNRWLDANEDDNEIVREMTAE 542
Cdd:cd01752    93 GKKWFFLCNDWLSVEEGDGTVERTFPVA 120
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 972-1081 8.72e-14

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 69.49  E-value: 8.72e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  972 FSVTIKTGDK-KNAGTDANVFITLFGTQDNNGMTLLKssktnsdkfeRDSIEiFTVETLDLGDLWKVRIGHDNTGKAPGW 1050
Cdd:cd01757     3 YHVVIVPSKKlGGSMFTANPWICVSGELGETPPLQIP----------KNSLE-MTFDCQNLGKLTTVQIGHDNSGLLAKW 71

                          90       100       110
                  ....*....|....*....|....*....|.
gi 261245013 1051 FVDWVEVDAPSLGKCMTFPCGRWLAKNEDDG 1081
Cdd:cd01757    72 LVEYVMVRNEITGHTYKFPCGRWLGEGVDDG 102
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 1953-2060 1.53e-13

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 68.72  E-value: 1.53e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1953 VIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKqkmRNLFErgstdrFFLETLELGELRKVRLEHDSSGYYSGWLVEKV 2032
Cdd:cd01757     6 VIVPSKKLGGSMFTANPWICVSGELGETPPLQIP---KNSLE------MTFDCQNLGKLTTVQIGHDNSGLLAKWLVEYV 76

                          90       100
                  ....*....|....*....|....*...
gi 261245013 2033 EVTNTSTGVATIFSCGRWLDKSRGDGLT 2060
Cdd:cd01757    77 MVRNEITGHTYKFPCGRWLGEGVDDGNG 104
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1103-1221 1.85e-13

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 68.61  E-value: 1.85e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  1103 YEITLYTSDVFAAGTDANIFIVIYGCDAVCTRQKFLCTNKReqklfFERKSASRFIVELE-DVGEIIeKIRIGHDNTGIN 1181
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD-----FERGAEDSFEIDTDwDVGAIL-KINLHWDNNGLS 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 261245013  1182 PGWHCSHVdirRLLPEKDGTETLTFPCDRWLATSEDDKKT 1221
Cdd:pfam01477   75 DEWFLKSI---TVEVPGETGGKYTFPCNSWVYGSKKYKET 111
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 554-670 3.11e-13

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 68.13  E-value: 3.11e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  554 RYRVTVCTGELEGAGTDANVYLCLFGDVGDTGErllYNCRNNTDLFEKGNADEFTIE-SVTMRKVRRVRVRHDGKGSGSG 632
Cdd:cd00113     2 RYTVTIKTGDKKGAGTDSNISLALYGENGNSSD---IPILDGPGSFERGSTDTFQIDlKLDIGDITKVYLRRDGSGLSDG 78

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 261245013  633 WYLDRVLVREEGqpESDNVEFPCLRWLDKDKDDGQLVR 670
Cdd:cd00113    79 WYCESITVQALG--TKKVYTFPVNRWVLGGKWYTSVRS 114
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1555-1662 5.28e-13

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 67.46  E-value: 5.28e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  1555 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEVQLDKKKARFEREQNDTFIMEI-LDIAPFTKMRIRIDGMGSRPEWFLE 1633
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEWFLK 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 261245013  1634 RILL-KNMNTGDLTMFYYGDWLSQKKGKKT 1662
Cdd:pfam01477   81 SITVeVPGETGGKYTFPCNSWVYGSKKYKE 110
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 555-664 6.17e-13

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 67.07  E-value: 6.17e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   555 YRVTVCTGELEGAGTDANVYLCLFGDVGDTGerLLYNCRNNTDlFEKGNADEFTI-ESVTMRKVRRVRVRHDGKGSGSGW 633
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESA--QLEITLDNPD-FERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDEW 77

                           90       100       110
                   ....*....|....*....|....*....|.
gi 261245013   634 YLDRVLVREEGQPESdNVEFPCLRWLDKDKD 664
Cdd:pfam01477   78 FLKSITVEVPGETGG-KYTFPCNSWVYGSKK 107
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
974-1077 6.56e-13

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 66.51  E-value: 6.56e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013    974 VTIKTGDKKNAGTDANVFITLFGTQDNNGMTLLKSSKTNSdkFERDSIEIFTVET-LDLGDLWKVRIGHDNtgKAPGWFV 1052
Cdd:smart00308    5 VTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGI--FARGSTYEFTFDVdEDFGELGAVKIKNEH--RHPEWFL 80

                            90       100
                    ....*....|....*....|....*
gi 261245013   1053 DWVEVDAPSLGKCMTFPCGRWLAKN 1077
Cdd:smart00308   81 KSITVKDLPTGGKYHFPCNSWVYPD 105
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
815-920 6.63e-13

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 66.51  E-value: 6.63e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013    815 HYEIEIWTGDVGGAGTTSRVFVQIYGEEGKTEVLFLSSRSKV-FDRGSKDIFQTDTFTiyaiDLGALTKIRIRHDNtgNR 893
Cdd:smart00308    2 KYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGiFARGSTYEFTFDVDE----DFGELGAVKIKNEH--RH 75

                            90       100
                    ....*....|....*....|....*..
gi 261245013    894 PGWFLDRVDITDVNNETTYYFPCQRWL 920
Cdd:smart00308   76 PEWFLKSITVKDLPTGGKYHFPCNSWV 102
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 554-673 9.01e-13

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 66.92  E-value: 9.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  554 RYRVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNcrNNTDLFEKGNADEF---------TIESVTMrkvrrvrvRH 624
Cdd:cd01752     2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRD--PEKPIFERGSVDSFllttpfplgELQSIRL--------WH 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 261245013  625 DGKGSGSGWYLDRVLVREegqPESDNV-EFPCLRWLDKDKDDGQLVRELL 673
Cdd:cd01752    72 DNSGLSPSWYLSRVIVRD---LQTGKKwFFLCNDWLSVEEGDGTVERTFP 118
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 1682-1788 1.32e-12

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 66.80  E-value: 1.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1682 YTVSVKTSDILGAGTDANVFIIIFGENGDSGTLALKQS------ANWNKFERNNTDTFNFSDMLSLGHLCKLRVWHDNKG 1755
Cdd:cd01754     3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGLRIANLEAwgglmgAGHDYFERGNLDRFSGRGPCLPSPPCWMNLTSDGTG 82

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 261245013 1756 IFPGWHLSYVDVK---DNSRDETFRFQCDCWLSKSE 1788
Cdd:cd01754    83 NHPGWYVNYVEVTqagQHAPCMQHLFAVEQWLATDE 118
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1950-2053 1.37e-12

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 65.74  E-value: 1.37e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   1950 KYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET-LELGELRKVRLEHDssGYYSGWL 2028
Cdd:smart00308    2 KYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGIFARGSTYEFTFDVdEDFGELGAVKIKNE--HRHPEWF 79

                            90       100
                    ....*....|....*....|....*
gi 261245013   2029 VEKVEVTNTSTGVATIFSCGRWLDK 2053
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSWVYP 104
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 685-790 3.55e-12

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 65.02  E-value: 3.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  685 RYHISVKTGDVSGASTDSRVYIKLYGEKSDTIKQVLLvsdnNLKDYFERGRVDEFTLE-TLNIGTINRLVIGHDSTGMHA 763
Cdd:cd01753     2 EYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLD----RPGYDFERGAVDEYKVKvPEDLGELLLVRLRKRKYLLFD 77

                          90       100
                  ....*....|....*....|....*..
gi 261245013  764 GWFLGSVQIRVPRQGKqYTFPANRWLD 790
Cdd:cd01753    78 AWFCNYITVTGPGGDE-YHFPCYRWIE 103
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 686-798 4.62e-12

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 65.25  E-value: 4.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  686 YHISVKTGDVSGASTDSRVYIKLYGEKSDTIKQVLLVSDNNLK----DYFERGRVDEFT--LETLNiGTINRLVIGHDST 759
Cdd:cd01754     3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGLRIANLEAWGGLMgaghDYFERGNLDRFSgrGPCLP-SPPCWMNLTSDGT 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 261245013  760 GMHAGWFLGSVQIRVPRQGK---QYTFPANRWLDKNQADGRL 798
Cdd:cd01754    82 GNHPGWYVNYVEVTQAGQHApcmQHLFAVEQWLATDESPYML 123
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1102-1212 1.27e-11

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 63.51  E-value: 1.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1102 PYEITLYTSDVFAAGTDANIFIVIYGcdAVCTRQKFLCTNKreqKLFFERKSASRFIVELE-DVGeIIEKIRIGHDNTGI 1180
Cdd:cd00113     2 RYTVTIKTGDKKGAGTDSNISLALYG--ENGNSSDIPILDG---PGSFERGSTDTFQIDLKlDIG-DITKVYLRRDGSGL 75

                          90       100       110
                  ....*....|....*....|....*....|..
gi 261245013 1181 NPGWHCSHVDIRRLlpekDGTETLTFPCDRWL 1212
Cdd:cd00113    76 SDGWYCESITVQAL----GTKKVYTFPVNRWV 103
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 971-1084 1.62e-11

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 63.10  E-value: 1.62e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  971 TFSVTIKTGDKKNAGTDANVFITLFGTQDNNGMTLLKSSKTNsdkFERDSIEIFTVE-TLDLGDLWKVRIGHDNTGKAPG 1049
Cdd:cd01753     2 EYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYD---FERGAVDEYKVKvPEDLGELLLVRLRKRKYLLFDA 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 261245013 1050 WFVDWVEVDAPSlGKCMTFPCGRWLaknEDDGSIV 1084
Cdd:cd01753    79 WFCNYITVTGPG-GDEYHFPCYRWI---EGYGTLE 109
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 173-280 2.34e-11

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 62.71  E-value: 2.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  173 KYEIKVYTGDVIGAGTDADVFINIFGEYGDTGERRLENEKDNFEKGAEDKFTLDAP-DLGQLMKINVgHNNKGGS-AGWF 250
Cdd:cd01753     2 EYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYDFERGAVDEYKVKVPeDLGELLLVRL-RKRKYLLfDAWF 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 261245013  251 LSKIIIEDIGNkRKYDFPLNRWLaldEDDG 280
Cdd:cd01753    81 CNYITVTGPGG-DEYHFPCYRWI---EGYG 106
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 43-152 6.88e-11

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 61.17  E-value: 6.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   43 KVYEVVTATGDVRGAGTDANVFITLFGENGLSPKlHLTSKSESAFEKANVDVFRVR-TNNVGLIYKIRIEHDNTGLNASW 121
Cdd:cd01753     1 AEYKVTVATGSSLFAGTDDYIYLTLVGTAGESEK-QLLDRPGYDFERGAVDEYKVKvPEDLGELLLVRLRKRKYLLFDAW 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 261245013  122 YLDRVIVTDmkrPHLRYY-FNCNNWlskVEGD 152
Cdd:cd01753    80 FCNYITVTG---PGGDEYhFPCYRW---IEGY 105
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
431-527 1.06e-10

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 60.35  E-value: 1.06e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013    431 VWTTDLKKAGTNSPIFIQIYGKKGRTDEILLNPNNKW-FKPGIIEKFRMELP-DLGRFYKIRAWHdrQNPGSGWHLEKMT 508
Cdd:smart00308    7 VTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGiFARGSTYEFTFDVDeDFGELGAVKIKN--EHRHPEWFLKSIT 84

                            90
                    ....*....|....*....
gi 261245013    509 LMNTINKDKYNFNCNRWLD 527
Cdd:smart00308   85 VKDLPTGGKYHFPCNSWVY 103
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 816-934 1.70e-10

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 60.24  E-value: 1.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  816 YEIEIWTGD-VGGAGTTSRVFVQIYGEEGKTEVLFLSsrskvfdrgsKDIFQtdtFTIYAIDLGALTKIRIRHDNTGNRP 894
Cdd:cd01757     3 YHVVIVPSKkLGGSMFTANPWICVSGELGETPPLQIP----------KNSLE---MTFDCQNLGKLTTVQIGHDNSGLLA 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 261245013  895 GWFLDRVDITDVNNETTYYFPCQRWLA-----VEEDDGQLSRELL 934
Cdd:cd01757    70 KWLVEYVMVRNEITGHTYKFPCGRWLGegvddGNGEDGSLERVLV 114
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 971-1078 2.59e-10

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 60.25  E-value: 2.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  971 TFSVTIKTGDKKNAGTDANVFITLF-----GTQDNNGMTLLKSSKTNSDKFERDSIEIFTVETLDL-GDLWKVRIGHDNT 1044
Cdd:cd01754     2 VYTIYVQTGSIWKAGTDSRISLQIYdadgpGLRIANLEAWGGLMGAGHDYFERGNLDRFSGRGPCLpSPPCWMNLTSDGT 81

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 261245013 1045 GKAPGWFVDWVEVDAPSLGK-CMT--FPCGRWLAKNE 1078
Cdd:cd01754    82 GNHPGWYVNYVEVTQAGQHApCMQhlFAVEQWLATDE 118
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 174-277 3.33e-10

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 59.86  E-value: 3.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  174 YEIKVYTGDVIGAGTDADVFINIFGEYGDTGE-RRLEN-------EKDNFEKGAEDKFTLDAPDL-GQLMKINVGHNNKG 244
Cdd:cd01754     3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGLRiANLEAwgglmgaGHDYFERGNLDRFSGRGPCLpSPPCWMNLTSDGTG 82

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 261245013  245 GSAGWFLSKIIIEDIGNKR---KYDFPLNRWLALDE 277
Cdd:cd01754    83 NHPGWYVNYVEVTQAGQHApcmQHLFAVEQWLATDE 118
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 686-799 3.49e-10

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 59.09  E-value: 3.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  686 YHISVKTGD-VSGASTDSRVYIKLYGEKSDTikQVLLVSDNNLkdyfergrvdEFTLETLNIGTINRLVIGHDSTGMHAG 764
Cdd:cd01757     3 YHVVIVPSKkLGGSMFTANPWICVSGELGET--PPLQIPKNSL----------EMTFDCQNLGKLTTVQIGHDNSGLLAK 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 261245013  765 WFLGSVQIRVPRQGKQYTFPANRWL-----DKNQADGRLE 799
Cdd:cd01757    71 WLVEYVMVRNEITGHTYKFPCGRWLgegvdDGNGEDGSLE 110
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 816-930 3.92e-10

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 58.86  E-value: 3.92e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  816 YEIEIWTGDVGGAGTTSRVFVQIYGEEGKTEVLFLSSRSKVFDRGSKDIFQTDTFTiyaiDLGALTKIRIRHDNTGNRPG 895
Cdd:cd01753     3 YKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYDFERGAVDEYKVKVPE----DLGELLLVRLRKRKYLLFDA 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 261245013  896 WFLDRVDITdVNNETTYYFPCQRWLaveEDDGQLS 930
Cdd:cd01753    79 WFCNYITVT-GPGGDEYHFPCYRWI---EGYGTLE 109
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 816-930 5.26e-10

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 59.09  E-value: 5.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  816 YEIEIWTGDVGGAGTTSRVFVQIYGEEGKT-EVLFLSSRSKV-------FDRGSKDIF--QTDTFTiyaidlGALTKIRI 885
Cdd:cd01754     3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGlRIANLEAWGGLmgaghdyFERGNLDRFsgRGPCLP------SPPCWMNL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 261245013  886 RHDNTGNRPGWFLDRVDITDVNNE---TTYYFPCQRWLAVEEDDGQLS 930
Cdd:cd01754    77 TSDGTGNHPGWYVNYVEVTQAGQHapcMQHLFAVEQWLATDESPYMLT 124
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 44-150 5.96e-10

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 59.09  E-value: 5.96e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   44 VYEVVTATGDVRGAGTDANVFITLFGENG-------LSPKLHLTSKSESAFEKANVDVFRVRTNNV-GLIYKIRIEHDNT 115
Cdd:cd01754     2 VYTIYVQTGSIWKAGTDSRISLQIYDADGpglrianLEAWGGLMGAGHDYFERGNLDRFSGRGPCLpSPPCWMNLTSDGT 81

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 261245013  116 GLNASWYLDRVIVTdMKRPHLR---YYFNCNNWLSKVE 150
Cdd:cd01754    82 GNHPGWYVNYVEVT-QAGQHAPcmqHLFAVEQWLATDE 118
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 1949-2058 7.51e-10

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 58.09  E-value: 7.51e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1949 VKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNlFERGSTDRFFLE-TLELGELRKVRLEHDSSGYYSGW 2027
Cdd:cd01753     1 AEYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYD-FERGAVDEYKVKvPEDLGELLLVRLRKRKYLLFDAW 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 261245013 2028 LVEKVEVTNTSTGVATiFSCGRWLDksrGDG 2058
Cdd:cd01753    80 FCNYITVTGPGGDEYH-FPCYRWIE---GYG 106
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 553-663 2.43e-09

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 56.93  E-value: 2.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  553 ARYRVTVCTGELEGAGTDANVYLCLfgdVGDTGERLLYNCRNNTDLFEKGNADEFTIESVTMRKVRRVRVRHDGK-GSGS 631
Cdd:cd01753     1 AEYKVTVATGSSLFAGTDDYIYLTL---VGTAGESEKQLLDRPGYDFERGAVDEYKVKVPEDLGELLLVRLRKRKyLLFD 77

                          90       100       110
                  ....*....|....*....|....*....|..
gi 261245013  632 GWYLDRVLVREegqPESDNVEFPCLRWLDKDK 663
Cdd:cd01753    78 AWFCNYITVTG---PGGDEYHFPCYRWIEGYG 106
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 1103-1216 4.09e-09

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 56.78  E-value: 4.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1103 YEITLYTSDVFAAGTDANIFIVIYGCDAVCTRQKFLctnKREQKL------FFERKSASRFIVELEDVGEIIEKIRIGHD 1176
Cdd:cd01754     3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGLRIANL---EAWGGLmgaghdYFERGNLDRFSGRGPCLPSPPCWMNLTSD 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 261245013 1177 NTGINPGWHCSHVDIrRLLPEKDGTETLTFPCDRWLATSE 1216
Cdd:cd01754    80 GTGNHPGWYVNYVEV-TQAGQHAPCMQHLFAVEQWLATDE 118
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
684-792 4.33e-09

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 55.73  E-value: 4.33e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013    684 FRYHISVKTGDVSGASTDSRVYIKLYGEKSDTIKQVLlvsDNNLKDYFERGRVDEFTLET-LNIGTINRLVIGHDSTgmH 762
Cdd:smart00308    1 GKYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKL---DYLFKGIFARGSTYEFTFDVdEDFGELGAVKIKNEHR--H 75

                            90       100       110
                    ....*....|....*....|....*....|
gi 261245013    763 AGWFLGSVQIRVPRQGKQYTFPANRWLDKN 792
Cdd:smart00308   76 PEWFLKSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 297-399 6.24e-09

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 55.78  E-value: 6.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  297 TYIVTVFTGDIRGAGTKSKIYLVMYGARGNKNSGKIFLEGGVFDRGRTDIFHIDLAVLLSPLSRVSIGHGNIGVNRGWYC 376
Cdd:cd01753     2 EYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYDFERGAVDEYKVKVPEDLGELLLVRLRKRKYLLFDAWFC 81

                          90       100
                  ....*....|....*....|...
gi 261245013  377 EKVVILCPFTGIqQTFPCSNWLD 399
Cdd:cd01753    82 NYITVTGPGGDE-YHFPCYRWIE 103
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 1255-1371 1.20e-08

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 54.85  E-value: 1.20e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1255 VLYSVQIFTGN-VPGAGTDAKVYITIYGDLGDTGERYLGKsenrtNKFEkgtadtFIIEAADLGVIYKIKLRHDNTKWCA 1333
Cdd:cd01757     1 MPYHVVIVPSKkLGGSMFTANPWICVSGELGETPPLQIPK-----NSLE------MTFDCQNLGKLTTVQIGHDNSGLLA 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 261245013 1334 DWYVEKVEIWNDTNEDEFLFLCGRWLS-----LKKEDGRLERL 1371
Cdd:cd01757    70 KWLVEYVMVRNEITGHTYKFPCGRWLGegvddGNGEDGSLERV 112
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 1951-2051 1.87e-08

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 54.85  E-value: 1.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1951 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGK-------RELKQKMRNLFERGSTDRFFLETLEL-GELRKVRLEHDSSG 2022
Cdd:cd01754     3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGLRianleawGGLMGAGHDYFERGNLDRFSGRGPCLpSPPCWMNLTSDGTG 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 261245013 2023 YYSGWLVEKVEVtnTSTGVAT-----IFSCGRWL 2051
Cdd:cd01754    83 NHPGWYVNYVEV--TQAGQHApcmqhLFAVEQWL 114
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 1424-1539 2.44e-08

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 54.20  E-value: 2.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1424 YYVSVTTGKHKEAATDSRAFVLLIGEDDEctnriwldypQGKRGFSCGSVEEFYVGGLDV---------GIIKKIELGHD 1494
Cdd:cd01752     3 YLVTVFTGWRRGAGTTAKVTITLYGAEGE----------SEPHHLRDPEKPIFERGSVDSfllttpfplGELQSIRLWHD 72

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 261245013 1495 GASPESCW-----LVEELclavPTQGTKYTLrCNCWLAKDRGDGVTSRVF 1539
Cdd:cd01752    73 NSGLSPSWylsrvIVRDL----QTGKKWFFL-CNDWLSVEEGDGTVERTF 117
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
298-401 2.72e-08

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 53.41  E-value: 2.72e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013    298 YIVTVFTGDIRGAGTKSKIYLVMYGARG-NKNSGKIFLEGGVFDRGRTDIFHIDLAVLLSPLSRVSIGHGNIGvnRGWYC 376
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGdGKESKLDYLFKGIFARGSTYEFTFDVDEDFGELGAVKIKNEHRH--PEWFL 80

                            90       100
                    ....*....|....*....|....*
gi 261245013    377 EKVVILCPFTGIQQTFPCSNWLDEK 401
Cdd:smart00308   81 KSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 297-398 2.77e-08

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 54.47  E-value: 2.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  297 TYIVTVFTGDIRGAGTKSKIYLVMYGARGNKNSGKiFLE--GGV-------FDRGRTDIFHIDLAVLLSPLSRVSIGHGN 367
Cdd:cd01754     2 VYTIYVQTGSIWKAGTDSRISLQIYDADGPGLRIA-NLEawGGLmgaghdyFERGNLDRFSGRGPCLPSPPCWMNLTSDG 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 261245013  368 IGVNRGWYCEKVVILCpfTGI-----QQTFPCSNWL 398
Cdd:cd01754    81 TGNHPGWYVNYVEVTQ--AGQhapcmQHLFAVEQWL 114
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1682-1786 3.34e-08

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 53.41  E-value: 3.34e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   1682 YTVSVKTSDILGAGTDANVFIIIFGENGDSGtLALKQSANWNKFERNNTDTFNFSDMLSLGHLCKLRVWHDNKgiFPGWH 1761
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGK-ESKLDYLFKGIFARGSTYEFTFDVDEDFGELGAVKIKNEHR--HPEWF 79

                            90       100
                    ....*....|....*....|....*
gi 261245013   1762 LSYVDVKDNSRDETFRFQCDCWLSK 1786
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSWVYP 104
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1424-1539 3.92e-08

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 53.59  E-value: 3.92e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  1424 YYVSVTTGKHKEAATDSRAFVLLIGEDDECTNR-IWLDYPqgkrGFSCGSVEEFYV-GGLDVGIIKKIELGHDGASPESC 1501
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLeITLDNP----DFERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDE 76

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 261245013  1502 WLVEELCLAVP-TQGTKYTLRCNCWLAKDRGDGVTsRVF 1539
Cdd:pfam01477   77 WFLKSITVEVPgETGGKYTFPCNSWVYGSKKYKET-RVF 114
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 45-148 5.34e-08

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 52.93  E-value: 5.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   45 YEVVTATGD-VRGAGTDANVFITLFGENGLSPKLHLTSKS-ESAFEkanvdvfrvrTNNVGLIYKIRIEHDNTGLNASWY 122
Cdd:cd01757     3 YHVVIVPSKkLGGSMFTANPWICVSGELGETPPLQIPKNSlEMTFD----------CQNLGKLTTVQIGHDNSGLLAKWL 72

                          90       100
                  ....*....|....*....|....*.
gi 261245013  123 LDRVIVTDMKRPHLrYYFNCNNWLSK 148
Cdd:cd01757    73 VEYVMVRNEITGHT-YKFPCGRWLGE 97
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 174-287 9.11e-08

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 52.54  E-value: 9.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  174 YEIKVYTGD-VIGAGTDADVFINIFGEYGDTGerRLENEKDNFEkgaedkFTLDAPDLGQLMKINVGHNNKGGSAGWFLS 252
Cdd:cd01757     3 YHVVIVPSKkLGGSMFTANPWICVSGELGETP--PLQIPKNSLE------MTFDCQNLGKLTTVQIGHDNSGLLAKWLVE 74

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 261245013  253 KIIIEDIGNKRKYDFPLNRWLALDEDDGKIQRDIL 287
Cdd:cd01757    75 YVMVRNEITGHTYKFPCGRWLGEGVDDGNGEDGSL 109
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
553-662 9.75e-08

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 51.87  E-value: 9.75e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013    553 ARYRVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNtdLFEKGNADEFTIESVTMRKVRRVRVRHDGKGSgSG 632
Cdd:smart00308    1 GKYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKG--IFARGSTYEFTFDVDEDFGELGAVKIKNEHRH-PE 77

                            90       100       110
                    ....*....|....*....|....*....|
gi 261245013    633 WYLDRVLVreEGQPESDNVEFPCLRWLDKD 662
Cdd:smart00308   78 WFLKSITV--KDLPTGGKYHFPCNSWVYPD 105
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1257-1362 1.10e-07

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 51.87  E-value: 1.10e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   1257 YSVQIFTGNVPGAGTDAKVYITIYGDLGDTGERYLGKSENrtNKFEKGTADTFIIE-AADLGVIYKIKLRHDNTKwcADW 1335
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFK--GIFARGSTYEFTFDvDEDFGELGAVKIKNEHRH--PEW 78

                            90       100
                    ....*....|....*....|....*..
gi 261245013   1336 YVEKVEIWNDTNEDEFLFLCGRWLSLK 1362
Cdd:smart00308   79 FLKSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 1684-1796 1.47e-07

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 51.77  E-value: 1.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1684 VSVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNtdtfnfsdmlsLGHLCKLRVWHDNKGIFPGWHLS 1763
Cdd:cd01757     6 VIVPSKKLGGSMFTANPWICVSGELGETPPLQIPKNSLEMTFDCQN-----------LGKLTTVQIGHDNSGLLAKWLVE 74

                          90       100       110
                  ....*....|....*....|....*....|...
gi 261245013 1764 YVDVKDNSRDETFRFQCDCWLSKSEGDRQTLRD 1796
Cdd:cd01757    75 YVMVRNEITGHTYKFPCGRWLGEGVDDGNGEDG 107
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
45-148 1.54e-07

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 51.49  E-value: 1.54e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013     45 YEVVTATGDVRGAGTDANVFITLFGENGLSPKLHLTSKSESAFEKANVDVFRVRTN-NVGLIYKIRIEHDNTGlnASWYL 123
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGIFARGSTYEFTFDVDeDFGELGAVKIKNEHRH--PEWFL 80

                            90       100
                    ....*....|....*....|....*
gi 261245013    124 DRVIVTDMKrPHLRYYFNCNNWLSK 148
Cdd:smart00308   81 KSITVKDLP-TGGKYHFPCNSWVYP 104
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 555-666 2.81e-07

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 51.00  E-value: 2.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  555 YRVTVCTGE-LEGAGTDANVYLCLFGDVGDTGERLLyncrnntdlfeKGNADEFTIESVTMRKVRRVRVRHDGKGSGSGW 633
Cdd:cd01757     3 YHVVIVPSKkLGGSMFTANPWICVSGELGETPPLQI-----------PKNSLEMTFDCQNLGKLTTVQIGHDNSGLLAKW 71

                          90       100       110
                  ....*....|....*....|....*....|...
gi 261245013  634 YLDRVLVREEgqPESDNVEFPCLRWLDKDKDDG 666
Cdd:cd01757    72 LVEYVMVRNE--ITGHTYKFPCGRWLGEGVDDG 102
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 1256-1342 5.13e-07

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 50.62  E-value: 5.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1256 LYSVQIFTGNVPGAGTDAKVYITIYGDLGDTG-----ERYLGKSENRTNKFEKGTADTFIIEAADL-GVIYKIKLRHDNT 1329
Cdd:cd01754     2 VYTIYVQTGSIWKAGTDSRISLQIYDADGPGLrianlEAWGGLMGAGHDYFERGNLDRFSGRGPCLpSPPCWMNLTSDGT 81

                          90
                  ....*....|...
gi 261245013 1330 KWCADWYVEKVEI 1342
Cdd:cd01754    82 GNHPGWYVNYVEV 94
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 1255-1360 5.98e-07

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 50.00  E-value: 5.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1255 VLYSVQIFTGNVPGAGTDAKVYITIygdLGDTGERYLGKSENRTNKFEKGTADTFIIEA-ADLGVIYKIKLRHDNTKWCA 1333
Cdd:cd01753     1 AEYKVTVATGSSLFAGTDDYIYLTL---VGTAGESEKQLLDRPGYDFERGAVDEYKVKVpEDLGELLLVRLRKRKYLLFD 77

                          90       100
                  ....*....|....*....|....*..
gi 261245013 1334 DWYVEKVEIwNDTNEDEFLFLCGRWLS 1360
Cdd:cd01753    78 AWFCNYITV-TGPGGDEYHFPCYRWIE 103
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1423-1535 6.87e-07

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 50.03  E-value: 6.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1423 PYYVSVTTGKHKEAATDSRAFVLLIGEDDectNRIWLDYPQGKRGFSCGSVEEFYV-GGLDVGIIKKIELGHDGASPESC 1501
Cdd:cd00113     2 RYTVTIKTGDKKGAGTDSNISLALYGENG---NSSDIPILDGPGSFERGSTDTFQIdLKLDIGDITKVYLRRDGSGLSDG 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 261245013 1502 WLVEelCLAVPTQGTK--YTLRCNCWLAKDRGDGVT 1535
Cdd:cd00113    79 WYCE--SITVQALGTKkvYTFPVNRWVLGGKWYTSV 112
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 555-668 1.40e-06

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 49.46  E-value: 1.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  555 YRVTVCTGELEGAGTDANVYLCLFGDVGDTG-----ERLLYNCRNNTDLFEKGNADEFTIESVTMRKVR-RVRVRHDGKG 628
Cdd:cd01754     3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGLrianlEAWGGLMGAGHDYFERGNLDRFSGRGPCLPSPPcWMNLTSDGTG 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 261245013  629 SGSGWYLDRVLVREEGQPESDNVE-FPCLRWLDKDKDDGQL 668
Cdd:cd01754    83 NHPGWYVNYVEVTQAGQHAPCMQHlFAVEQWLATDESPYML 123
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 1103-1223 2.11e-06

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 48.46  E-value: 2.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1103 YEITLYTSDVFAAGTDANIFIVIYGCDAVCTRQKFLCTNKReqklfFERKSASRFIVEL-EDVGEIIeKIRIGHDNTGIN 1181
Cdd:cd01753     3 YKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYD-----FERGAVDEYKVKVpEDLGELL-LVRLRKRKYLLF 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 261245013 1182 PGWHCSHVDIRRLlpekdGTETLTFPCDRWLatseDDKKTIR 1223
Cdd:cd01753    77 DAWFCNYITVTGP-----GGDEYHFPCYRWI----EGYGTLE 109
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
 1256-1359 3.83e-06

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 47.46  E-value: 3.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1256 LYSVQIFTGNVPGAGTDAKVYITIYGDLGDTGERYLgksenrTNKFEKGTADTFIIEAADLGVIYKIKLRhdNTKWCADW 1335
Cdd:cd02899     2 TYTASVQTGKDKEAGTNGTIEITLLGSSGRSNPKTL------SQGFYPGSLKRIRFRAADVGDINAIILS--NTALNDPW 73

                          90       100
                  ....*....|....*....|....
gi 261245013 1336 YVEKVEIWNDTNEdEFLFLCGRWL 1359
Cdd:cd02899    74 YCDYVRIKSEDGK-VFAFNVKRWI 96
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 1681-1785 1.04e-05

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 46.53  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1681 SYTVSVKTSDILGAGTDANVFIIIFGENGDSGTLALKqsaNWNK-FERNNTDTFNFSDMLSLGHLCKLRVWHDNKGIFPG 1759
Cdd:cd01753     2 EYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLD---RPGYdFERGAVDEYKVKVPEDLGELLLVRLRKRKYLLFDA 78

                          90       100
                  ....*....|....*....|....*.
gi 261245013 1760 WHLSYVDVKDNSRDEtFRFQCDCWLS 1785
Cdd:cd01753    79 WFCNYITVTGPGGDE-YHFPCYRWIE 103
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1555-1655 1.18e-05

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 46.10  E-value: 1.18e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   1555 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEVQLDK-KKARFEREQNDTFIMEI-LDIAPFTKMRIRIDgmGSRPEWFL 1632
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYlFKGIFARGSTYEFTFDVdEDFGELGAVKIKNE--HRHPEWFL 80

                            90       100
                    ....*....|....*....|...
gi 261245013   1633 ERILLKNMNTGDLTMFYYGDWLS 1655
Cdd:smart00308   81 KSITVKDLPTGGKYHFPCNSWVY 103
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1424-1529 3.54e-05

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 44.55  E-value: 3.54e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   1424 YYVSVTTGKHKEAATDSRAFVLLIGEDDECTNRIwlDYPQGKRGFSCGSVEEFYV-GGLDVGIIKKIELGHDGASPEscW 1502
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESK--LDYLFKGIFARGSTYEFTFdVDEDFGELGAVKIKNEHRHPE--W 78

                            90       100
                    ....*....|....*....|....*..
gi 261245013   1503 LVEELCLAVPTQGTKYTLRCNCWLAKD 1529
Cdd:smart00308   79 FLKSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 431-530 1.13e-04

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 43.45  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  431 VWTTDLKKAGTNSPIFIQIYGKKGRTDEILLNPNNKWFKPGIIEKFRMELP-DLG-----RFYKIRAWHDrqnpgSGWHL 504
Cdd:cd01753     7 VATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYDFERGAVDEYKVKVPeDLGelllvRLRKRKYLLF-----DAWFC 81

                          90       100
                  ....*....|....*....|....*.
gi 261245013  505 EKMTLmNTINKDKYNFNCNRWLDANE 530
Cdd:cd01753    82 NYITV-TGPGGDEYHFPCYRWIEGYG 106
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1813-1914 1.43e-04

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 43.10  E-value: 1.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1813 YEIVIETGN--GGETRENVWLILEGR-KNRSKEFLVENSSRqraFRKGTTDTFEFDsiFLGDIASLCVGHLAREDrfiPK 1889
Cdd:cd00113     3 YTVTIKTGDkkGAGTDSNISLALYGEnGNSSDIPILDGPGS---FERGSTDTFQID--LKLDIGDITKVYLRRDG---SG 74

                          90       100
                  ....*....|....*....|....*
gi 261245013 1890 RELVWHVKTITITEMEYGNVYFFNC 1914
Cdd:cd00113    75 LSDGWYCESITVQALGTKKVYTFPV 99
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
 43-148 1.53e-04

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 42.84  E-value: 1.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013   43 KVYEVVTATGDVRGAGTDANVFITLFGENGLSPKLHLTskseSAFEKANVDVFRVRTNNVGLIYKIRIEhdNTGLNASWY 122
Cdd:cd02899     1 KTYTASVQTGKDKEAGTNGTIEITLLGSSGRSNPKTLS----QGFYPGSLKRIRFRAADVGDINAIILS--NTALNDPWY 74

                          90       100
                  ....*....|....*....|....*..
gi 261245013  123 LDRV-IVTDMKRphlRYYFNCNNWLSK 148
Cdd:cd02899    75 CDYVrIKSEDGK---VFAFNVKRWIGY 98
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 355-411 3.89e-04

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 42.14  E-value: 3.89e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 261245013  355 LSPLSRVSIGHGNIGVNRGWYCEKVVILCPFTGIQQTFPCSNWL-----DEKKADGLIERQL 411
Cdd:cd01757    52 LGKLTTVQIGHDNSGLLAKWLVEYVMVRNEITGHTYKFPCGRWLgegvdDGNGEDGSLERVL 113
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 1553-1664 5.21e-04

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 41.53  E-value: 5.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1553 VLYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEVQLDKKKARFEREQNDTFIMEI-LDIAPFTKMRIRIDGMGSRPEWF 1631
Cdd:cd01753     1 AEYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYDFERGAVDEYKVKVpEDLGELLLVRLRKRKYLLFDAWF 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 261245013 1632 LERILLKNMNtGDLTMFYYGDWLSqkkGKKTLV 1664
Cdd:cd01753    81 CNYITVTGPG-GDEYHFPCYRWIE---GYGTLE 109
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
 1950-2053 5.31e-04

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 41.29  E-value: 5.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1950 KYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKmrnlFERGSTDRFFLETLELGELRKVRLEHDSSGyySGWLV 2029
Cdd:cd02899     2 TYTASVQTGKDKEAGTNGTIEITLLGSSGRSNPKTLSQG----FYPGSLKRIRFRAADVGDINAIILSNTALN--DPWYC 75

                          90       100
                  ....*....|....*....|....
gi 261245013 2030 EKVEVtNTSTGVATIFSCGRWLDK 2053
Cdd:cd02899    76 DYVRI-KSEDGKVFAFNVKRWIGY 98
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 1422-1535 9.03e-04

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 40.98  E-value: 9.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1422 IPYYVSVTTGKHKEAA-TDSRAFVLLIGEDDEcTNRiwldyPQGKRGfscgsVEEFYVGGLDVGIIKKIELGHDGASPES 1500
Cdd:cd01757     1 MPYHVVIVPSKKLGGSmFTANPWICVSGELGE-TPP-----LQIPKN-----SLEMTFDCQNLGKLTTVQIGHDNSGLLA 69

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 261245013 1501 CWLVEELCLAVPTQGTKYTLRCNCWLAKDRGDGVT 1535
Cdd:cd01757    70 KWLVEYVMVRNEITGHTYKFPCGRWLGEGVDDGNG 104
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 1101-1218 1.36e-03

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 40.60  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1101 VPYEITLYTSD-VFAAGTDANIFIVIYGCdavctrqkfLCTNKREQklfFERKSASrFIVELEDVGeIIEKIRIGHDNTG 1179
Cdd:cd01757     1 MPYHVVIVPSKkLGGSMFTANPWICVSGE---------LGETPPLQ---IPKNSLE-MTFDCQNLG-KLTTVQIGHDNSG 66

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 261245013 1180 INPGWHCSHVDIRRllpEKDGtETLTFPCDRWLATSEDD 1218
Cdd:cd01757    67 LLAKWLVEYVMVRN---EITG-HTYKFPCGRWLGEGVDD 101
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
 971-1076 2.05e-03

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 39.75  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  971 TFSVTIKTGDKKNAGTDANVFITLFGtqdNNGMTllkSSKTNSDKFERDSIEIFTVETLDLGDLWKVRIGhdNTGKAPGW 1050
Cdd:cd02899     2 TYTASVQTGKDKEAGTNGTIEITLLG---SSGRS---NPKTLSQGFYPGSLKRIRFRAADVGDINAIILS--NTALNDPW 73

                          90       100
                  ....*....|....*....|....*.
gi 261245013 1051 FVDWVEVDAPSlGKCMTFPCGRWLAK 1076
Cdd:cd02899    74 YCDYVRIKSED-GKVFAFNVKRWIGY 98
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
 173-273 3.80e-03

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 38.98  E-value: 3.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013  173 KYEIKVYTGDVIGAGTDADVFINIFGEYGDTGERRLeneKDNFEKGAEDKFTLDAPDLGQLMKINVghNNKGGSAGWFLS 252
Cdd:cd02899     2 TYTASVQTGKDKEAGTNGTIEITLLGSSGRSNPKTL---SQGFYPGSLKRIRFRAADVGDINAIIL--SNTALNDPWYCD 76

                          90       100
                  ....*....|....*....|.
gi 261245013  253 KIIIEDiGNKRKYDFPLNRWL 273
Cdd:cd02899    77 YVRIKS-EDGKVFAFNVKRWI 96
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 1554-1637 9.00e-03

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 38.29  E-value: 9.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245013 1554 LYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEVQLDKKKARFEREQNDTFIMEILDI---------APFTKMRIRIDGM 1624
Cdd:cd01754     2 VYTIYVQTGSIWKAGTDSRISLQIYDADGPGLRIANLEAWGGLMGAGHDYFERGNLDRfsgrgpclpSPPCWMNLTSDGT 81

                          90
                  ....*....|...
gi 261245013 1625 GSRPEWFLERILL 1637
Cdd:cd01754    82 GNHPGWYVNYVEV 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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