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Conserved domains on  [gi|27436867|ref|NP_775101|]
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SLIT and NTRK-like protein 4 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
59-213 4.43e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 4.43e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867  59 SNFYHLNFQNNFLNILyPNTFLNFSHAVSLHLGNNKLQNIeGGAFLGLSALKQLHLNNNELKILrADTFLGIENLEYLQA 138
Cdd:COG4886 113 TNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDL 189

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27436867 139 DYNLIKYIErGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIgrvVELQLEDN 213
Cdd:COG4886 190 SNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNL---EELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
358-531 2.48e-14

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.13  E-value: 2.48e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867 358 SVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDvSDFTDFEGLDLLHLGSNQITVIkGDVFHNLTNLRRLYLNGNQI 437
Cdd:COG4886 117 SLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQI 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867 438 ERLyPEIFSGLHNLQYLYLEYNLIKEISAgTFDSMPNlqllylnnnllkslpvyifsgapLARLNLRNNKFMYLPvsgVL 517
Cdd:COG4886 195 TDL-PEPLGNLTNLEELDLSGNQLTDLPE-PLANLTN-----------------------LETLDLSNNQLTDLP---EL 246

                       170
                ....*....|....
gi 27436867 518 DQLQSLTQIDLEGN 531
Cdd:COG4886 247 GNLTNLEELDLSNN 260
LRRCT smart00082
Leucine rich repeat C-terminal domain;
213-253 8.91e-07

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 46.27  E-value: 8.91e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 27436867    213 NPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLL 253
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLL 41
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 502-563 1.13e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 42.76  E-value: 1.13e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27436867    502 NLRNNKFMYLPvSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWVEKLSDGIVVKELK-CETP 563
Cdd:TIGR00864    1 DISNNKISTIE-EGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAAlCAGP 62
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
59-213 4.43e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 4.43e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867  59 SNFYHLNFQNNFLNILyPNTFLNFSHAVSLHLGNNKLQNIeGGAFLGLSALKQLHLNNNELKILrADTFLGIENLEYLQA 138
Cdd:COG4886 113 TNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDL 189

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27436867 139 DYNLIKYIErGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIgrvVELQLEDN 213
Cdd:COG4886 190 SNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNL---EELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
358-531 2.48e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.13  E-value: 2.48e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867 358 SVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDvSDFTDFEGLDLLHLGSNQITVIkGDVFHNLTNLRRLYLNGNQI 437
Cdd:COG4886 117 SLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQI 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867 438 ERLyPEIFSGLHNLQYLYLEYNLIKEISAgTFDSMPNlqllylnnnllkslpvyifsgapLARLNLRNNKFMYLPvsgVL 517
Cdd:COG4886 195 TDL-PEPLGNLTNLEELDLSGNQLTDLPE-PLANLTN-----------------------LETLDLSNNQLTDLP---EL 246

                       170
                ....*....|....
gi 27436867 518 DQLQSLTQIDLEGN 531
Cdd:COG4886 247 GNLTNLEELDLSNN 260
LRR_8 pfam13855
Leucine rich repeat;
402-461 1.53e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.01  E-value: 1.53e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867   402 GLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLI 461
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
83-143 6.08e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 6.08e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27436867    83 SHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLI 143
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 359-458 6.24e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.18  E-value: 6.24e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867 359 VNCQEKNIQSMSELIPKPlNAKKLHVNGNSIKDVDVSDFtdFEGLDLLHLGSNQITVIKGdvFHNLTNLRRLYLNGNQIE 438
Cdd:cd21340   7 LYLNDKNITKIDNLSLCK-NLKVLYLYDNKITKIENLEF--LTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS 81

                        90       100
                ....*....|....*....|
gi 27436867 439 RLypEIFSGLHNLQYLYLEY 458
Cdd:cd21340  82 VV--EGLENLTNLEELHIEN 99
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 63-233 3.03e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.18  E-value: 3.03e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867  63 HLNFQNNflNILYPNTFLNFSHAVSLHLGNNKLQNIEGgaFLGLSALKQLHLNNNelKILRADTFLGIENLEYLQADYNL 142
Cdd:cd21340   6 HLYLNDK--NITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNN--QIEKIENLENLVNLKKLYLGGNR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867 143 IKYIErgAFNKLHKLKVL-ILNDNL-----ISFLPDNIFRFA-SLTHLDIRGNRIQKLPYIGVLEHIgrvVELQLEDnpw 215
Cdd:cd21340  80 ISVVE--GLENLTNLEELhIENQRLppgekLTFDPRSLAALSnSLRVLNISGNNIDSLEPLAPLRNL---EQLDASN--- 151

                       170
                ....*....|....*...
gi 27436867 216 NCSCDLLPLKAWLENMPY 233
Cdd:cd21340 152 NQISDLEELLDLLSSWPS 169
LRRCT smart00082
Leucine rich repeat C-terminal domain;
213-253 8.91e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 46.27  E-value: 8.91e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 27436867    213 NPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLL 253
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLL 41
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 502-563 1.13e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 42.76  E-value: 1.13e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27436867    502 NLRNNKFMYLPvSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWVEKLSDGIVVKELK-CETP 563
Cdd:TIGR00864    1 DISNNKISTIE-EGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAAlCAGP 62
LRRCT smart00082
Leucine rich repeat C-terminal domain;
531-563 6.67e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 35.48  E-value: 6.67e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 27436867    531 NPWDCTCDLVALKLWVEKLSDGIVVKELKCETP 563
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASP 33
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
59-213 4.43e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 4.43e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867  59 SNFYHLNFQNNFLNILyPNTFLNFSHAVSLHLGNNKLQNIeGGAFLGLSALKQLHLNNNELKILrADTFLGIENLEYLQA 138
Cdd:COG4886 113 TNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDL 189

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27436867 139 DYNLIKYIErGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIgrvVELQLEDN 213
Cdd:COG4886 190 SNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNL---EELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
358-531 2.48e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.13  E-value: 2.48e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867 358 SVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDvSDFTDFEGLDLLHLGSNQITVIkGDVFHNLTNLRRLYLNGNQI 437
Cdd:COG4886 117 SLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQI 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867 438 ERLyPEIFSGLHNLQYLYLEYNLIKEISAgTFDSMPNlqllylnnnllkslpvyifsgapLARLNLRNNKFMYLPvsgVL 517
Cdd:COG4886 195 TDL-PEPLGNLTNLEELDLSGNQLTDLPE-PLANLTN-----------------------LETLDLSNNQLTDLP---EL 246

                       170
                ....*....|....
gi 27436867 518 DQLQSLTQIDLEGN 531
Cdd:COG4886 247 GNLTNLEELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
63-214 6.31e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.58  E-value: 6.31e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867  63 HLNFQNNFLNILyPNTFLNFSHAVSLHLGNNKLQNIeGGAFLGLSALKQLHLNNNELKILrADTFLGIENLEYLQADYNL 142
Cdd:COG4886 140 ELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQ 216

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27436867 143 IKYIERgAFNKLHKLKVLILNDNLISFLPdNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGrvvELQLEDNP 214
Cdd:COG4886 217 LTDLPE-PLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLK---TLDLSNNQ 283
LRR_8 pfam13855
Leucine rich repeat;
402-461 1.53e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.01  E-value: 1.53e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867   402 GLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLI 461
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
83-143 6.08e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 6.08e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27436867    83 SHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLI 143
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
378-437 1.47e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.53  E-value: 1.47e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867   378 NAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQI 437
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 359-458 6.24e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.18  E-value: 6.24e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867 359 VNCQEKNIQSMSELIPKPlNAKKLHVNGNSIKDVDVSDFtdFEGLDLLHLGSNQITVIKGdvFHNLTNLRRLYLNGNQIE 438
Cdd:cd21340   7 LYLNDKNITKIDNLSLCK-NLKVLYLYDNKITKIENLEF--LTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS 81

                        90       100
                ....*....|....*....|
gi 27436867 439 RLypEIFSGLHNLQYLYLEY 458
Cdd:cd21340  82 VV--EGLENLTNLEELHIEN 99
LRR_8 pfam13855
Leucine rich repeat;
425-473 2.88e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 2.88e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 27436867   425 TNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSMP 473
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP 49
LRR_8 pfam13855
Leucine rich repeat;
132-190 2.55e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 2.55e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867   132 NLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFR-FASLTHLDIRGNRI 190
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
109-167 3.02e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 3.02e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 27436867   109 LKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLI 167
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 63-233 3.03e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.18  E-value: 3.03e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867  63 HLNFQNNflNILYPNTFLNFSHAVSLHLGNNKLQNIEGgaFLGLSALKQLHLNNNelKILRADTFLGIENLEYLQADYNL 142
Cdd:cd21340   6 HLYLNDK--NITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNN--QIEKIENLENLVNLKKLYLGGNR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867 143 IKYIErgAFNKLHKLKVL-ILNDNL-----ISFLPDNIFRFA-SLTHLDIRGNRIQKLPYIGVLEHIgrvVELQLEDnpw 215
Cdd:cd21340  80 ISVVE--GLENLTNLEELhIENQRLppgekLTFDPRSLAALSnSLRVLNISGNNIDSLEPLAPLRNL---EQLDASN--- 151

                       170
                ....*....|....*...
gi 27436867 216 NCSCDLLPLKAWLENMPY 233
Cdd:cd21340 152 NQISDLEELLDLLSSWPS 169
LRR_8 pfam13855
Leucine rich repeat;
59-119 5.48e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 5.48e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27436867    59 SNFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNEL 119
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
377-531 6.85e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.63  E-value: 6.85e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867 377 LNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQItvikgdvFHNLTNLRRLYLNGNQIERLyPEIFSGLHNLQYLYL 456
Cdd:COG4886  72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDL 143

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27436867 457 EYNLIKEISAgTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSgvLDQLQSLTQIDLEGN 531
Cdd:COG4886 144 SNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEP--LGNLTNLEELDLSGN 215
LRRCT smart00082
Leucine rich repeat C-terminal domain;
213-253 8.91e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 46.27  E-value: 8.91e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 27436867    213 NPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLL 253
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLL 41
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 63-194 1.10e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.17  E-value: 1.10e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867  63 HLNFQNNFLNILypntfLNFSHAVSL---HLGNNKLQNIEGgaFLGLSALKQLHLNNNELK-----ILRADTFLGI-ENL 133
Cdd:cd21340  50 HLYLQNNQIEKI-----ENLENLVNLkklYLGGNRISVVEG--LENLTNLEELHIENQRLPpgeklTFDPRSLAALsNSL 122

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27436867 134 EYLQADYNLIKYIErgAFNKLHKLKVLILNDNLISFLPD---NIFRFASLTHLDIRGNRIQKLP 194
Cdd:cd21340 123 RVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEElldLLSSWPSLRELDLTGNPVCKKP 184
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
42-465 1.27e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.39  E-value: 1.27e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867  42 NCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKI 121
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867 122 LRADTFLGIENLEYLQADYNLIKYiERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLP-YIGVLE 200
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTELDLS-GNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPePLGNLT 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867 201 HIgrvVELQLEDNPwncscdllplkawLENMPYNIyigeaicetpsdlygrllketnkqelcpmgtgsdfdvrilppSQL 280
Cdd:COG4886 160 NL---KSLDLSNNQ-------------LTDLPEEL------------------------------------------GNL 181

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867 281 engyttpnghttqTSLHRLVtkppkttnpskisgivagkaLSNRNLSQIvsyqtrvppltpcpapcfckthPSDLGlsvn 360
Cdd:COG4886 182 -------------TNLKELD--------------------LSNNQITDL----------------------PEPLG---- 202

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867 361 cqekniqSMSELipkplnaKKLHVNGNSIKDVDvSDFTDFEGLDLLHLGSNQITVIkgDVFHNLTNLRRLYLNGNQIERL 440
Cdd:COG4886 203 -------NLTNL-------EELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDL 265

                       410       420
                ....*....|....*....|....*
gi 27436867 441 YPEifSGLHNLQYLYLEYNLIKEIS 465
Cdd:COG4886 266 PPL--ANLTNLKTLDLSNNQLTDLK 288
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 425-466 6.01e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.00  E-value: 6.01e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 27436867   425 TNLRRLYLNGNQIERLypEIFSGLHNLQYLYLEYN-LIKEISA 466
Cdd:pfam12799   1 PNLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNnKITDLSD 41
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 93-188 8.35e-04

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 40.22  E-value: 8.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867    93 NKLQNIEGGAFLGLSALKQLHLNNNeLKILRADTFLGIeNLEYLQADYNlIKYIERGAFNKLHKLKVLILNDNLISFlPD 172
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNC-SLTSITIPSS-LTSIGEYAFSNCSNLKSITLPSNLTSI-GS 95

                          90
                  ....*....|....*.
gi 27436867   173 NIFRFASLTHLDIRGN 188
Cdd:pfam13306  96 YAFSNCSLKSITIPSS 111
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-464 9.85e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 9.85e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867  52 NQLKPPWSNFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLhLNNNELKILRADTFLGIE 131
Cdd:COG4886  35 LALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDL-TNLTELDLSGNEELSNLT 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867 132 NLEYLQADYNLIKYIERgAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPyiGVLEHIGRVVELQLE 211
Cdd:COG4886 114 NLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLP--EELGNLTNLKELDLS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867 212 DNPwncscdllplkawLENMPYNIyigeaicetpsdlygrllketnkqelcpmgtgsdfdvrilppSQLENgyttpnght 291
Cdd:COG4886 191 NNQ-------------ITDLPEPL------------------------------------------GNLTN--------- 206

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867 292 tqtsLHRLvtkppkttnpskisgivagkALSNRNLSQIvsyqtrvppltpcpapcfckthpsdlglsvncqEKNIQSMSE 371
Cdd:COG4886 207 ----LEEL--------------------DLSGNQLTDL---------------------------------PEPLANLTN 229

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867 372 LipkplnaKKLHVNGNSIKDVdvSDFTDFEGLDLLHLGSNQITVIkgDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNL 451
Cdd:COG4886 230 L-------ETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGL 298

                       410
                ....*....|...
gi 27436867 452 QYLYLEYNLIKEI 464
Cdd:COG4886 299 NSLLLLLLLLNLL 311
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 502-563 1.13e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 42.76  E-value: 1.13e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27436867    502 NLRNNKFMYLPvSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWVEKLSDGIVVKELK-CETP 563
Cdd:TIGR00864    1 DISNNKISTIE-EGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAAlCAGP 62
LRR_8 pfam13855
Leucine rich repeat;
156-214 1.47e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.47e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867   156 KLKVLILNDNLISFLPDNIFR-FASLTHLDIRGNRIQKLPYiGVLEHIGRVVELQLEDNP 214
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNR 60
LRRCT smart00082
Leucine rich repeat C-terminal domain;
531-563 6.67e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 35.48  E-value: 6.67e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 27436867    531 NPWDCTCDLVALKLWVEKLSDGIVVKELKCETP 563
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASP 33
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 351-466 8.72e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.39  E-value: 8.72e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436867 351 HPSDLGlSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDF----TDFEGLDLLHLGSNQIT----VIKGDVFH 422
Cdd:COG5238 183 ETVYLG-CNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILaealKGNKSLTTLDLSNNQIGdegvIALAEALK 261

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 27436867 423 NLTNLRRLYLNGNQIE----RLYPEIFSGLHNLQYLYLEYNLIKEISA 466
Cdd:COG5238 262 NNTTVETLYLSGNQIGaegaIALAKALQGNTTLTSLDLSVNRIGDEGA 309
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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