|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
90-1018 |
0e+00 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 1179.41 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 90 PGEKKDVSGPLPPAYSPQYVEAAWYQWWVREGFFKP-EYQARLPQatGETFSMCIPPPNVTGSLHIGHALTVAIQDALVR 168
Cdd:PTZ00419 14 KKNKKRNISSMAASYDPKEVESGWYEWWEKSGFFKPaEDAKSLNS--GKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 169 WHRMRGDRVLWIPGSDHAGIATQAMVEKQLWKEQRVRRHELSREDFLRAVWQWKHEKGGEIYEQLCALGASLDWDRECFT 248
Cdd:PTZ00419 92 YHRMKGDETLWVPGTDHAGIATQVVVEKKLMKEENKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSLDWSREVFT 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 249 MDAGSSAAVTEAFVRLYNSGLLYRNRQLVNWSCTLRSAISDIEVESRPLPGRTVLQLPGCPTPVSFGLLASVAFPVDGEP 328
Cdd:PTZ00419 172 MDEQRSKAVKEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEKPTKITIPGYDKKVEVGVLWHFAYPLEDSG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 329 DTEIVVGTTRPETLPGDVAVAVHPDDPRYTHLHGRQLRHPLT-GQLLPLITDTT-VQPHVGTGAVKVTPAHSPIDAEIGT 406
Cdd:PTZ00419 252 QEEIVVATTRIETMLGDVAVAVHPKDERYKKLHGKELIHPFIpDRKIPIIADDElVDMEFGTGAVKITPAHDPNDYEIAK 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 407 RHGLTPLSVIAEDGTMTSLCGDWlQGLHRFVAREKIMCTLREQGLFRGLQEHPMVLPICSRSGDVVEYLLKSQWFVRCQE 486
Cdd:PTZ00419 332 RHNLPFINIFTLDGKINENGGEF-AGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGDIVEPMLIPQWYVNCKD 410
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 487 MGDLAAKAVESGALELWPSFHQKSWQHWFAHIGDWCVSRQLWWGHQIPAYRVIGENAEDDRK--ECWVVGRSEAEARAVA 564
Cdd:PTZ00419 411 MAKRAVEAVRNGELKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPAYRVISKGPETDPSdeEPWVVARSEEEALEKA 490
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 565 AKRTGRPEAELTLERDPDVLDTWFSSALFPFSALGWPRETPDLAHFYPLTLLETGSDLLMFWVGRMVMLGTQLTGQLPFS 644
Cdd:PTZ00419 491 KKKFGLSEEDFELEQDEDVLDTWFSSGLFPFSTLGWPDQTDDLQRFFPTSLLETGSDILFFWVARMVMMSLHLTDKLPFK 570
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 645 KVLLHSMVRDRQGRKMSKSLGNVLDPRDIISGQELQVLQAKLRDGNLDPGELAVAAAAQKKDFPYGIPECGTDALRFALC 724
Cdd:PTZ00419 571 TVFLHAMVRDSQGEKMSKSKGNVIDPLEVIEGISLQDLNQKLYEGNLPEKEIKRAIELQKKEFPNGIPECGTDALRFGLL 650
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 725 SHGILGGDLHLSVSEVLNYRHFCNKLWNALRFVLRALGDNFVPQPAEEVTPSSP-----MDAWILSRLAFAASECERGFL 799
Cdd:PTZ00419 651 AYTQQGRNINLDINRVVGYRHFCNKLWNAVKFALMKLLKDFNLPNSTLFKPNNVeslpwEDKWILHRLNVAIKEVTEGFK 730
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 800 SRELSLVTHTLYHFWLHNLCDVYLEAVKPVLSSVPRPP---GPPQVLFSCADVGLRLLAPLMPFLAEELWQRLPPRPGGP 876
Cdd:PTZ00419 731 EYDFSEATQATYNFWLYELCDVYLELIKPRLSKQSDGErkqHAQDVLHTVLDIGLRLLHPMMPFITEELYQRLPNYLRKS 810
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 877 laPSICVAPYPSTRSLefWRQPELERCFSRVQEVVQALRALRATYQLT-KARPQVLLQCSDPGEQGLVQP---FLEPLGI 952
Cdd:PTZ00419 811 --ESISIAKYPQPNPG--WNNEALDEEMKIIMSIVKSIRSLIATLGIPnKTKPDCYVTAKDAELIELIESaenLISTLAK 886
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 160333671 953 LSHCGAVGFLSPGAAAPSGWALTPLGDTMKIYMELQGLVDPQSQLPRLTARRQKLQKQLDDLLNRT 1018
Cdd:PTZ00419 887 IGSVSVIPPIEEEAEVPKGCGFDVVDNKVIIYLNLDEFIDLKKELAKLEKKLAKLQKSLESYLKKI 952
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
100-1012 |
0e+00 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 991.48 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 100 LPPAYSPQYVEAAWYQWWVREGFFKPEyqarlPQATGETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDRVLW 179
Cdd:COG0525 3 LPKTYDPKEVEAKWYQYWEENGYFKAD-----PDSDKEPFTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLW 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 180 IPGSDHAGIATQAMVEKQLwKEQRVRRHELSREDFLRAVWQWKHEKGGEIYEQLCALGASLDWDRECFTMDAGSSAAVTE 259
Cdd:COG0525 78 QPGTDHAGIATQAVVERQL-AEEGKSRHDLGREKFLERVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVRE 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 260 AFVRLYNSGLLYRNRQLVNWSCTLRSAISDIEVESRPLPGRtvlqlpgcptpvsfglLASVAFPVDGEPDtEIVVGTTRP 339
Cdd:COG0525 157 VFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVKGH----------------LWHIRYPLADGSG-YIVVATTRP 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 340 ETLPGDVAVAVHPDDPRYTHLHGRQLRHPLTGQLLPLITDTTVQPHVGTGAVKVTPAHSPIDAEIGTRHGLTPLSVIAED 419
Cdd:COG0525 220 ETMLGDTAVAVHPEDERYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILDED 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 420 GTMTSLCGDwLQGLHRFVAREKIMCTLREQGLFRGLQEHPMVLPICSRSGDVVEYLLKSQWFVRCQEMGDLAAKAVESGA 499
Cdd:COG0525 300 GTINENAGK-YRGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPAIEAVEDGE 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 500 LELWPSFHQKSWQHWFAHIGDWCVSRQLWWGHQIPAYrvIGENAEddrkecWVVGRSEAEARAVAAkrtgrpeaELTLER 579
Cdd:COG0525 379 IKFVPERWEKTYFHWMENIRDWCISRQLWWGHRIPAW--YCPDGE------VYVARTEPEACAKAG--------SVNLTQ 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 580 DPDVLDTWFSSALFPFSALGWPRETPDLAHFYPLTLLETGSDLLMFWVGRMVMLGTQLTGQLPFSKVLLHSMVRDRQGRK 659
Cdd:COG0525 443 DEDVLDTWFSSALWPFSTLGWPEKTEDLKYFYPTSVLVTGFDIIFFWVARMIMMGLHFTGEVPFKDVYIHGLVRDEQGRK 522
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 660 MSKSLGNVLDPRDIISgqelqvlqaklrdgnldpgelavaaaaqkkdfpygipECGTDALRFALCSHGILGGDLHLSVSE 739
Cdd:COG0525 523 MSKSKGNVIDPLDLID-------------------------------------KYGADALRFTLAALASPGRDIKFDEER 565
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 740 VLNYRHFCNKLWNALRFVLRaLGDNFVPQPAEEVTPSSPMDAWILSRLAFAASECERGFLSRELSLVTHTLYHF-WlHNL 818
Cdd:COG0525 566 VEGYRNFANKLWNASRFVLM-NLEGFDPGLDPDPEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALYDFvW-NEF 643
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 819 CDVYLEAVKPVLSSvprpPGPPQ------VLFSCADVGLRLLAPLMPFLAEELWQRLPPRPGGplaPSICVAPYPSTRsl 892
Cdd:COG0525 644 CDWYLELAKPRLYG----GDEAAkretraTLVYVLEQILRLLHPFMPFITEEIWQKLPPRKEG---ESIMLAPWPEAD-- 714
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 893 EFWRQPELERCFSRVQEVVQALRALRATYQLT-KARPQVLLQCSDPGEQGLVQPFLEPLGILSHCGAVGFLSpgAAAPSG 971
Cdd:COG0525 715 EELIDEEAEAEFEWLKEVISAIRNIRAEMNIPpSKKLPLLLKGADEADRARLEENAAYIKRLARLEEITILV--DEKPEG 792
|
890 900 910 920
....*....|....*....|....*....|....*....|.
gi 160333671 972 wALTPLGDTMKIYMELQGLVDPQSQLPRLTARRQKLQKQLD 1012
Cdd:COG0525 793 -AASAVVGGAEVFLPLEGLIDVEAERARLEKELAKLEKEIA 832
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
44-1050 |
0e+00 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 969.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 44 REAKQKRLREKQAALEAGLAEKSK-----IPAVPTKAWSHKEV-----VLYEIPTGP-GEKKDVSGPLPPAYSPQYVEAA 112
Cdd:PLN02381 29 KEKELKKLKAAQKEAKAKLQAQQAsdgtnVPKKSEKKSRKRDVedenpEDFIDPDTPfGQKKRLSSQMAKQYSPSAVEKS 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 113 WYQWWVREGFFKPEyqarlPQATGETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDRVLWIPGSDHAGIATQA 192
Cdd:PLN02381 109 WYAWWEKSGYFGAD-----AKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGIATQV 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 193 MVEKQLWKEQRVRRHELSREDFLRAVWQWKHEKGGEIYEQLCALGASLDWDRECFTMDAGSSAAVTEAFVRLYNSGLLYR 272
Cdd:PLN02381 184 VVEKKLMRERHLTRHDIGREEFVSEVWKWKDEYGGTILNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRLYKEGLIYR 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 273 NRQLVNWSCTLRSAISDIEVESRPLPGRTVLQLPGCPTPVSFGLLASVAFPVDGEPDtEIVVGTTRPETLPGDVAVAVHP 352
Cdd:PLN02381 264 DIRLVNWDCTLRTAISDVEVDYIDIKERTLLKVPGYDKPVEFGVLTSFAYPLEGGLG-EIVVATTRIETMLGDTAIAIHP 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 353 DDPRYTHLHGRQLRHPLTGQLLPLITDTT-VQPHVGTGAVKVTPAHSPIDAEIGTRHGLTPLSVIAEDGTMTSLCGDWLQ 431
Cdd:PLN02381 343 DDERYKHLHGKFAVHPFNGRKLPIICDAIlVDPNFGTGAVKITPAHDPNDFEVGKRHNLEFINIFTDDGKINSNGGSEFA 422
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 432 GLHRFVAREKIMCTLREQGLFRGLQEHPMVLPICSRSGDVVEYLLKSQWFVRCQEMGDLAAKAV---ESGALELWPSFHQ 508
Cdd:PLN02381 423 GMPRFAAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNDVVEPMIKPQWFVNCSSMAKQALDAAidgENKKLEFIPKQYL 502
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 509 KSWQHWFAHIGDWCVSRQLWWGHQIPAYRVIGEnaEDDRKEC------WVVGRSEAEARAVAAKRTgrPEAELTLERDPD 582
Cdd:PLN02381 503 AEWKRWLENIRDWCISRQLWWGHRIPAWYVTLE--DDQLKELgsyndhWVVARNESDALLEASQKF--PGKKFELSQDPD 578
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 583 VLDTWFSSALFPFSALGWPRETPDLAHFYPLTLLETGSDLLMFWVGRMVMLGTQLTGQLPFSKVLLHSMVRDRQGRKMSK 662
Cdd:PLN02381 579 VLDTWFSSGLFPLSVLGWPDDTDDLKAFYPTSVLETGHDILFFWVARMVMMGMQLGGDVPFRKVYLHPMIRDAHGRKMSK 658
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 663 SLGNVLDPRDIISGQELQVLQAKLRDGNLDPGELAVAAAAQKKDFPYGIPECGTDALRFALCSHGILGGDLHLSVSEVLN 742
Cdd:PLN02381 659 SLGNVIDPLEVINGISLEGLHKRLEEGNLDPKELVVAKEGQKKDFPNGIAECGTDALRFALVSYTAQSDKINLDILRVVG 738
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 743 YRHFCNKLWNALRFVLRALGDNFVPQPAEEVTPSSPMDAWILSRLAFAASECERGFLSRELSLVTHTLYHFWLHNLCDVY 822
Cdd:PLN02381 739 YRQWCNKLWNAVRFAMSKLGDDYTPPATLSVETMPFSCKWILSVLNKAISKTVSSLDAYEFSDAASTVYSWWQYQFCDVF 818
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 823 LEAVKPVLSS-----VPRPPGPPQVLFSCADVGLRLLAPLMPFLAEELWQRLPPRPGGPLAPSICVAPYPStrSLEFWRQ 897
Cdd:PLN02381 819 IEAIKPYFAGdnpefASERAAAQDTLWICLDTGLRLLHPFMPFVTEELWQRLPQPKDHTRKDSIMISEYPS--AVEAWTN 896
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 898 PELERCFSRVQEVVQALRALRATY---QLTKARPQVLLqCSDPGEQGLVQPFLEPLGILSHCGAVGFLSPGA-AAPSGWA 973
Cdd:PLN02381 897 EKVEYEMDLVLSTVKCLRSLRAEVlekQKNERLPAFAL-CRNQEIAAIIKSHQLEILTLANLSSLKVLLSENdAPPAGCA 975
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 160333671 974 LTPLGDTMKIYMELQGLVDPQSQLPRLTARRQKLQKQLDDLLNRTMSEGLAERqqriSSLHLELSKLDQAASYLQQL 1050
Cdd:PLN02381 976 FENVNENLKVYLQAQGAVNAEAELEKLRNKMDEIQKQQEKLEKKMNASGYKEK----VPANIQEEDARKLTKLLQEL 1048
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
100-1012 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 966.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 100 LPPAYSPQYVEAAWYQWWVREGFFKPEyqarlpQATGETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDRVLW 179
Cdd:PRK05729 5 LPKTYDPKEVEAKWYQKWEEKGYFKPD------DNSKKPFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLW 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 180 IPGSDHAGIATQAMVEKQLWKEQrVRRHELSREDFLRAVWQWKHEKGGEIYEQLCALGASLDWDRECFTMDAGSSAAVTE 259
Cdd:PRK05729 79 LPGTDHAGIATQMVVERQLAAEG-KSRHDLGREKFLEKVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVRE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 260 AFVRLYNSGLLYRNRQLVNWSCTLRSAISDIEVESRPLPGRtvlqlpgcptpvsfglLASVAFPVDgEPDTEIVVGTTRP 339
Cdd:PRK05729 158 VFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEVEYKEVKGK----------------LWHIRYPLA-DGSDYLVVATTRP 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 340 ETLPGDVAVAVHPDDPRYTHLHGRQLRHPLTGQLLPLITDTTVQPHVGTGAVKVTPAHSPIDAEIGTRHGLTPLSVIAED 419
Cdd:PRK05729 221 ETMLGDTAVAVNPEDERYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDED 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 420 GTMTSLCGDwLQGLHRFVAREKIMCTLREQGLFRGLQEHPMVLPICSRSGDVVEYLLKSQWFVRCQEMGDLAAKAVESGA 499
Cdd:PRK05729 301 GTINENPGE-YQGLDRFEARKAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPALEAVENGE 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 500 LELWPSFHQKSWQHWFAHIGDWCVSRQLWWGHQIPAYRvigenaedDRKECWVVGRSEAEARAVAAkrtgrpeaeltLER 579
Cdd:PRK05729 380 IKFVPERWEKTYFHWMENIQDWCISRQLWWGHRIPAWY--------DEDGEVYVGREEPEAREKAL-----------LTQ 440
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 580 DPDVLDTWFSSALFPFSALGWPRETPDLAHFYPLTLLETGSDLLMFWVGRMVMLGTQLTGQLPFSKVLLHSMVRDRQGRK 659
Cdd:PRK05729 441 DEDVLDTWFSSALWPFSTLGWPEKTEDLKRFYPTSVLVTGFDIIFFWVARMIMMGLHFTGQVPFKDVYIHGLVRDEQGRK 520
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 660 MSKSLGNVLDPRDIISgqelqvlqaklrdgnldpgelavaaaaqkkdfPYgipecGTDALRFALCSHGILGGDLHLSVSE 739
Cdd:PRK05729 521 MSKSKGNVIDPLDLID--------------------------------KY-----GADALRFTLAALASPGRDIRFDEER 563
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 740 VLNYRHFCNKLWNALRFVLRALGDNFVPQPAEEvTPSSPMDAWILSRLAFAASECERGFLSRELSLVTHTLYHFWLHNLC 819
Cdd:PRK05729 564 VEGYRNFANKLWNASRFVLMNLEGADVGELPDP-EELSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEFIWNEFC 642
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 820 DVYLEAVKPVLSSvPRPPGPPQVLFSCADVGLRLLAPLMPFLAEELWQRLPPRPGgplAPSICVAPYPSTRSLEFwrqPE 899
Cdd:PRK05729 643 DWYLELAKPVLQE-AAKRATRATLAYVLEQILRLLHPFMPFITEELWQKLAPLGI---EESIMLAPWPEADEAID---EA 715
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 900 LERCFSRVQEVVQALRALRATYQLTKARP-QVLLQCSDPGEQGLVQPFLEPLGILSHCGAVGFLSPGAAAPSGwALTPLG 978
Cdd:PRK05729 716 AEAEFEWLKELITAIRNIRAEMNIPPSKKlPLLLKGADAEDRARLEANEAYIKRLARLESLEILADDEEAPEG-AASAVV 794
|
890 900 910
....*....|....*....|....*....|....
gi 160333671 979 DTMKIYMELQGLVDPQSQLPRLTARRQKLQKQLD 1012
Cdd:PRK05729 795 GGAELFLPLEGLIDVEAELARLEKELAKLEKEIE 828
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
100-1012 |
0e+00 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 842.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 100 LPPAYSPQYVEAAWYQWWVREGFFKPEyqarlPQATGETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDRVLW 179
Cdd:TIGR00422 1 MPKDYDPHEVEKKWYKKWEKSGFFKPD-----GNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLW 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 180 IPGSDHAGIATQAMVEKQLWKEqRVRRHELSREDFLRAVWQWKHEKGGEIYEQLCALGASLDWDRECFTMDAGSSAAVTE 259
Cdd:TIGR00422 76 LPGTDHAGIATQVKVEKKLGAE-GKTKHDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 260 AFVRLYNSGLLYRNRQLVNWSCTLRSAISDIEVESRPLPGrtvlQLPGcptpvsfgllasVAFPVDGEPDTEIVVGTTRP 339
Cdd:TIGR00422 155 AFVRLYEKGLIYRGEYLVNWDPKLNTAISDIEVEYKEVKG----KLYY------------IRYPLANGSKDYLVVATTRP 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 340 ETLPGDVAVAVHPDDPRYTHLHGRQLRHPLTGQLLPLITDTTVQPHVGTGAVKVTPAHSPIDAEIGTRHGLTPLSVIAED 419
Cdd:TIGR00422 219 ETMFGDTAVAVHPEDERYKHLIGKKVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILDED 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 420 GTMTSLCGDWlQGLHRFVAREKIMCTLREQGLFRGLQEHPMVLPICSRSGDVVEYLLKSQWFVRCQEMGDLAAKAVESGA 499
Cdd:TIGR00422 299 GLLNENAGKY-QGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALEAAEEGE 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 500 LELWPSFHQKSWQHWFAHIGDWCVSRQLWWGHQIPAYRVigenaeddrKEC--WVVGRSEAEARAVAakrtgRPEAELTL 577
Cdd:TIGR00422 378 IKFVPKRMEKRYLNWLRNIKDWCISRQLIWGHRIPVWYC---------KECgeVYVAKEEPLPDDKT-----NTGPSVEL 443
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 578 ERDPDVLDTWFSSALFPFSALGWPRETPDLAHFYPLTLLETGSDLLMFWVGRMVMLGTQLTGQLPFSKVLLHSMVRDRQG 657
Cdd:TIGR00422 444 EQDTDVLDTWFSSSLWPFSTLGWPDETKDLKKFYPTDLLVTGYDIIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQG 523
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 658 RKMSKSLGNVLDPRDIISgqelqvlqaklrdgnldpgelavaaaaqkkdfpygipECGTDALRFALCSHGILGGDLHLSV 737
Cdd:TIGR00422 524 RKMSKSLGNVIDPLDVIE-------------------------------------KYGADALRFTLASLVTPGDDINFDW 566
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 738 SEVLNYRHFCNKLWNALRFVLRALGDNFVPQPAEEvtPSSPMDAWILSRLAFAASECERGFLSRELSLVTHTLYHFWLHN 817
Cdd:TIGR00422 567 KRVESARNFLNKLWNASRFVLMNLSDDLELSGGEE--KLSLADRWILSKLNRTIKEVRKALDKYRFAEAAKALYEFIWND 644
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 818 LCDVYLEAVKPVL--SSVPRPPGPPQVLFSCADVGLRLLAPLMPFLAEELWQRLPPRpggplAPSICVAPYPSTrsLEFW 895
Cdd:TIGR00422 645 FCDWYIELVKYRLynGNEAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFKEG-----ADSIMLQSYPVV--DAEF 717
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 896 RQPELERCFSRVQEVVQALRALRATYQLTKARP-QVLLQCSDPGEQGLVQPFLEPLGILSHCGAVGFLSpgAAAPSGWAL 974
Cdd:TIGR00422 718 VDEEAEKAFELLKEIIVSIRNLKAESNIPPNAPlKVLLIYTEAETAERLKLNAVDIKGAINFSEVEVVI--EKPEVTEAV 795
|
890 900 910
....*....|....*....|....*....|....*...
gi 160333671 975 TPLGDTMKIYMELQGLVDpqsqlprLTARRQKLQKQLD 1012
Cdd:TIGR00422 796 VELVPGFEIIIPVKGLIN-------KAKELARLQKQLD 826
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
100-1017 |
0e+00 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 741.81 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 100 LPPAYSPQYVEAAWYQWWVREGFFKPEYQARlpqaTGETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDRVLW 179
Cdd:PRK14900 15 LAKGYEHREVEARWYPFWQERGYFHGDEHDR----TRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLW 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 180 IPGSDHAGIATQAMVEKQLWKEQRVRRHELSREDFLRAVWQWKHEKGGEIYEQLCALGASLDWDRECFTMDAGSSAAVTE 259
Cdd:PRK14900 91 LPGTDHAGIATQMIVEKELKKTEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVRE 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 260 AFVRLYNSGLLYRNRQLVNWSCTLRSAISDIEVESRPLPGrtvlqlpgcptpvsfGLLASVAFPV-DGepDTEIVVGTTR 338
Cdd:PRK14900 171 VFVRLHEEGLIYREKKLINWCPDCRTALSDLEVEHEEAHQ---------------GELWSFAYPLaDG--SGEIVVATTR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 339 PETLPGDVAVAVHPDDPRYTHLHGRQLRHPLTGQLLPLITDTT-VQPHVGTGAVKVTPAHSPIDAEIGTRHGLTPLSVIA 417
Cdd:PRK14900 234 PETMLGDTAVAVHPLDPRYMALHGKKVRHPITGRTFPIVADAIlVDPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIG 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 418 EDGTMTSLCGDwLQGLHRFVAREKIMCTLREQGLFRGLQEHPMVLPICSRSGDVVEYLLKSQWFVRCQEMGDLAAKAVES 497
Cdd:PRK14900 314 PDGRMTAEAGP-LAGLDRFEARKEVKRLLAEQGLDRGAKPHVLPLGRCQRSATILEPLLSDQWYVRIEPLARPAIEAVEQ 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 498 GALELWPSFHQKSWQHWFAHIGDWCVSRQLWWGHQIPAYRVIGENAeddrkecwVVGRSEAEARAVAAKRtgrpeaelTL 577
Cdd:PRK14900 393 GRTRFIPEQWTNTYMAWMRNIHDWCISRQLWWGHQIPAWYCPDGHV--------TVARETPEACSTCGKA--------EL 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 578 ERDPDVLDTWFSSALFPFSALGWPRETPDLAHFYPLTLLETGSDLLMFWVGRMVMLGTQLTGQLPFSKVLLHSMVRDRQG 657
Cdd:PRK14900 457 RQDEDVLDTWFSSGLWPFSTMGWPEQTDTLRTFYPTSVMETGHDIIFFWVARMMMMGLHFMGEVPFRTVYLHPMVRDEKG 536
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 658 RKMSKSLGNVLDPRDIisgqelqvlqaklrdgnldpgelavaaaaqkkdfpygIPECGTDALRFALCSHGILGGDLHLSV 737
Cdd:PRK14900 537 QKMSKTKGNVIDPLVI-------------------------------------TEQYGADALRFTLAALTAQGRDIKLAK 579
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 738 SEVLNYRHFCNKLWNALRFVLRALGDNFVPQPAEEVTPSSPMDAWILSRLAFAASECERGFLSRELSLVTHTLYHFWLHN 817
Cdd:PRK14900 580 ERIEGYRAFANKLWNASRFALMNLSGYQERGEDPARLARTPADRWILARLQRAVNETVEALEAFRFNDAANAVYAFVWHE 659
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 818 LCDVYLEAVKPVLSSV-PRPPGPPQ-VLFSCADVGLRLLAPLMPFLAEELWQRLPPRPGGPLAP-SICVAPYPSTRSLEf 894
Cdd:PRK14900 660 LCDWYIELAKEALASEdPEARRSVQaVLVHCLQTSYRLLHPFMPFITEELWHVLRAQVGASAWAdSVLAAEYPRKGEAD- 738
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 895 wrqPELERCFSRVQEVVQALRALRATYQLT-----KARPQVLLQCSDPGEQGLVQ-PFLEPLGILSHCGAVGFLSPGAAA 968
Cdd:PRK14900 739 ---EAAEAAFRPVLGIIDAVRNIRGEMGIPwkvklGAQAPVEIAVADPALRDLLQaGELARVHRVAGVEGSRLVVAAATA 815
|
890 900 910 920
....*....|....*....|....*....|....*....|....*....
gi 160333671 969 PSGWALTPLGDTMKIYMELQGLVDPQSQLPRLTARRQKLQKQLDDLLNR 1017
Cdd:PRK14900 816 PAPQSAVGVGPGFEVRVPLAGVIDLAAETARVDKEIGKVDQDLAVLERK 864
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
114-1026 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 658.94 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 114 YQWWVREGFFKPEYQArlpqaTGETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDRVLWIPGSDHAGIATQAM 193
Cdd:PLN02943 70 YNWWESQGYFKPNFDR-----GGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIATQLV 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 194 VEKQLWKEQrVRRHELSREDFLRAVWQWKHEKGGEIYEQLCALGASLDWDRECFTMDAGSSAAVTEAFVRLYNSGLLYRN 273
Cdd:PLN02943 145 VEKMLASEG-IKRTDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQG 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 274 RQLVNWSCTLRSAISDIEVESRPLPGRtvlqlpgcptpvsfglLASVAFPVDGEPDTEIVVGTTRPETLPGDVAVAVHPD 353
Cdd:PLN02943 224 SYMVNWSPNLQTAVSDLEVEYSEEPGT----------------LYYIKYRVAGGSEDFLTIATTRPETLFGDVAIAVNPE 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 354 DPRYTHLHGRQLRHPLT-GQLLPLITDTTVQPHVGTGAVKVTPAHSPIDAEIGTRHGLTPLSVIAEDGTMTSLCGdwlqg 432
Cdd:PLN02943 288 DDRYSKYIGKMAIVPMTyGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDGTLNEVAG----- 362
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 433 LHRFVAREKIMCTLREQGLFRGLQEHPMVLPICSRSGDVVEYLLKSQWFVRCQEMGDLAAKAVESGALELWPSFHQKSWQ 512
Cdd:PLN02943 363 LYWFEAREKLWSDLEETGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVTMEPLAEKALKAVENGELTIIPERFEKIYN 442
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 513 HWFAHIGDWCVSRQLWWGHQIPAYRVIGENAEDDrkecWVVGRSEAEARAVAAKRTGRpeaELTLERDPDVLDTWFSSAL 592
Cdd:PLN02943 443 HWLSNIKDWCISRQLWWGHRIPVWYIVGKDCEED----YIVARSAEEALEKAREKYGK---DVEIYQDPDVLDTWFSSAL 515
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 593 FPFSALGWPR-ETPDLAHFYPLTLLETGSDLLMFWVGRMVMLGTQLTGQLPFSKVLLHSMVRDRQGRKMSKSLGNVLDPR 671
Cdd:PLN02943 516 WPFSTLGWPDvSAEDFKKFYPTTVLETGHDILFFWVARMVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPL 595
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 672 DIIsgqelqvlqaklrdgnldpgelavaaaaqkKDFpygipecGTDALRFALcSHGILGGDLHLSVSEVLNYRHFCNKLW 751
Cdd:PLN02943 596 DTI------------------------------KEF-------GTDALRFTL-ALGTAGQDLNLSTERLTSNKAFTNKLW 637
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 752 NALRFVLRALGDNFVPQP----------AEEVTPSSPM-DAWILSRLAFAASECERGFLSRELSLVTHTLYHFWLHNLCD 820
Cdd:PLN02943 638 NAGKFVLQNLPSQSDTSAwehilackfdKEESLLSLPLpECWVVSKLHELIDSVTTSYDKYFFGDVGREIYDFFWSDFAD 717
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 821 VYLEAVKPVL---SSVPRPPGPPQVLFSCADVGLRLLAPLMPFLAEELWQRLPPRpggplAPSICVAPYPsTRSLEfwRQ 897
Cdd:PLN02943 718 WYIEASKTRLyhsGDNSALSRAQAVLLYVFENILKLLHPFMPFVTEELWQALPYR-----KEALIVSPWP-QTSLP--KD 789
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 898 PELERCFSRVQEVVQALRALRATYQLTKARPQVLLQCSDPGEQGLVQPFLEPLGILSHCG--AVGFLS--PGAAAPSGWA 973
Cdd:PLN02943 790 LKSIKRFENLQSLTRAIRNARAEYSVEPAKRISASIVASAEVIEYISKEKEVLALLSRLDlqNVHFTDspPGDANQSVHL 869
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|...
gi 160333671 974 LTPLGdtMKIYMELQGLVDPQSQLPRLTARRQKLQKQLDDLLNRTMSEGLAER 1026
Cdd:PLN02943 870 VASEG--LEAYLPLADMVDISAEVERLSKRLSKMQTEYDALAARLSSPKFVEK 920
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
112-736 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 609.41 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 112 AWYQWWVREGFFKPEYQARLPQatgETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDRVLWIPGSDHAGIATQ 191
Cdd:pfam00133 1 QIYEFWDEQGYFKPELEKRKGK---PSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 192 AMVEKQLWKEQRVRRHELSREDFLRAVWQWKHEKGGEIYEQLCALGASLDWDRECFTMDAGSSAAVTEAFVRLYNSGLLY 271
Cdd:pfam00133 78 QVVEKKLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 272 RNRQLVNWSCTLRSAISDIEVESRPLPGRTVlqlpgcptpvsfgllaSVAFPVDGEPDTEIVVGTTRPETLPGDVAVAVH 351
Cdd:pfam00133 158 RGKKLVNWSPALNTALSNLEVEYKDVKGPSI----------------HVAFPLADDEGASLVIWTTTPWTLPGNTAVAVN 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 352 PD-------------------------------DPRYTHLHGRQLRHPLTGQLLPLITDTTVQPHVGTGAVKVTPAHSPI 400
Cdd:pfam00133 222 PEfdyvitgegyilaeallkslykkgtdkkileDFRGKELEGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGEN 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 401 DAEIGTRHGLTPLSVIAEDGTMTSLCGDWlQGLHRFVAREKIMCTLREQGLFRGLQEHPMVLPICSRSGDVVEYLLKSQW 480
Cdd:pfam00133 302 DYEVGQRHNLEVINPVDDDGTFTEEAPDF-QGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQW 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 481 FVRCQEMGDLAAKAVESgaLELWPSFHQKSWQHWFAHIGDWCVSRQLWWGHQIPAYRVIGENAEDDRKEC--WVVGRSEA 558
Cdd:pfam00133 381 FVRMDELADQALEAVEK--VQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEVVCRGELfeLVAGRFEE 458
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 559 EARAVA----AKRTGRPEAElTLERDPDVLDTWFSSALFPFSALGWPRE-TPDLAHFYPLTLLETGSDLLMFWVGRMVML 633
Cdd:pfam00133 459 EGSIKWlhreAKDKLGYGKG-TLEQDEDVLDTWFSSGSWPFSTLGWPFVnTEEFKKFFPADMLLEGSDQTRGWFYRMIML 537
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 634 GTQLTGQLPFSKVLLHSMVRDRQGRKMSKSLGNVLDPRDIISgqelqvlqaklrdgnldpgelavaaaaqkkdfpygipE 713
Cdd:pfam00133 538 STALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVID-------------------------------------K 580
|
650 660
....*....|....*....|...
gi 160333671 714 CGTDALRFALCSHGiLGGDLHLS 736
Cdd:pfam00133 581 YGADALRLWLANSD-YGRDINLS 602
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
137-735 |
4.01e-177 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 521.81 E-value: 4.01e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 137 ETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDRVLWIPGSDHAGIATQAMVEKQLWKEQrVRRHELSREDFLR 216
Cdd:cd00817 1 PVFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEG-KTRHDLGREEFLE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 217 AVWQWKHEKGGEIYEQLCALGASLDWDRECFTMDAGSSAAVTEAFVRLYNSGLLYRNRQLVNWSCTLRSAISDIEVesrp 296
Cdd:cd00817 80 KCWEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV---- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 297 lpgrtvlqlpgcptpvsfgllasvafpvdgepdteivvgttrpetlpgdvavavhpddprythlhgrqlrhpltgqllpl 376
Cdd:cd00817 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 377 itdttvqphvgtgavkvtpahspidaeigtrhgltplsviaedgtmtslcgdwlqglhrfvarekimctlreqglfrglq 456
Cdd:cd00817 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 457 ehpmvlpiCSRSGDVVEYLLKSQWFVRCQEMGDLAAKAVESGALELWPSFHQKSWQHWFAHIGDWCVSRQLWWGHQIPAY 536
Cdd:cd00817 156 --------CSRSGDVIEPLLKPQWFVKVKDLAKKALEAVKEGDIKFVPERMEKRYENWLENIRDWCISRQLWWGHRIPAW 227
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 537 RVIGENAeddrkecWVVGRSEAEARAVAAKRTGRPEAELTLERDPDVLDTWFSSALFPFSALGWPRETPDLAHFYPLTLL 616
Cdd:cd00817 228 YCKDGGH-------WVVAREEDEAIDKAAPEACVPCGGEELKQDEDVLDTWFSSSLWPFSTLGWPEETKDLKKFYPTSLL 300
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 617 ETGSDLLMFWVGRMVMLGTQLTGQLPFSKVLLHSMVRDRQGRKMSKSLGNVLDPRDIISGqelqvlqaklrdgnldpgel 696
Cdd:cd00817 301 VTGHDIIFFWVARMIMRGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDG-------------------- 360
|
570 580 590
....*....|....*....|....*....|....*....
gi 160333671 697 avaaaaqkkdfpygipeCGTDALRFALCSHGILGGDLHL 735
Cdd:cd00817 361 -----------------YGADALRFTLASAATQGRDINL 382
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
100-915 |
2.67e-138 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 436.16 E-value: 2.67e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 100 LPPAYSPQYVEAAWYQWWVREGFFKPEyqarlPQATGETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDRVLW 179
Cdd:PRK13208 6 LPKKYDPEELEEKWQKIWEEEGTYKFD-----PDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 180 IPGSDHAGIATQAMVEKQLwkeqRVRRHELSREDFLRAVWQWKHEKGGEIYEQLCALGASLDWDRECFTMDAGSSAAVTE 259
Cdd:PRK13208 81 PQGWDDNGLPTERKVEKYY----GIRKDDISREEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQK 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 260 AFVRLYNSGLLYRNRQLVNWSCTLRSAISDIEVESRPLPGrtvlqlpgcptpvsfgLLASVAFPVDGepDTEIVVGTTRP 339
Cdd:PRK13208 157 SFLDLYKKGLIYRAEAPVLWCPRCETAIAQAEVEYREREG----------------KLNYIKFPVED--GEEIEIATTRP 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 340 ETLPGDVAVAVHPDDPRYTHLHGRQLRHPLTGQLLPLITDTTVQPHVGTGAVKVTPAHSPIDAEIGTRHGLTPLSVIAED 419
Cdd:PRK13208 219 ELLPACVAVVVHPDDERYKHLVGKTAIVPLFGVEVPILADPLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRIIIDED 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 420 GTMTSLCGDwLQGLHRFVAREKIMCTLREQGLFrGLQE---HPmvLPICSRSGDVVEYLLKSQWFVRcqeMGDLAAKAVE 496
Cdd:PRK13208 299 GRMTEAAGK-LAGLTIEEARKKIVEDLKSGGLL-GKQEpikHN--VKFCERCDTPLEILVTRQWFIK---VLDLKEELLE 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 497 SGA-LELWPSFHQKSWQHWFAHI-GDWCVSRQ--------LWW----GHQIPAyrvigenaedDRKECWVVGRSEAEARA 562
Cdd:PRK13208 372 RGKeINWYPEHMRVRLENWIEGLnWDWCISRQryfgtpipVWYckdcGHPILP----------DEEDLPVDPTKDEPPGY 441
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 563 VAAKRTGRPeaeltLERDPDVLDTWFSSALFPFSALGWPRETPDLAHFYPLTLLETGSDLLMFW----VGRMVmlgtQLT 638
Cdd:PRK13208 442 KCPQCGSPG-----FEGETDVMDTWATSSITPLIVTGWERDEDLFEKVFPMDLRPQGHDIIRTWlfytILRAY----LLT 512
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 639 GQLPFSKVLLHSMVRDRQGRKMSKSLGNVLDPRDIisgqelqvlqaklrdgnldpgelavaaaaqkkdfpygIPECGTDA 718
Cdd:PRK13208 513 GKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEEL-------------------------------------LEKYGADA 555
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 719 LRFALCShGILGGDLHLSVSEVLNYRHFCNKLWNALRFVLrALGDNFVPQPAEEvtpSSPMDAWILSRLAFAASECERGF 798
Cdd:PRK13208 556 VRYWAAS-ARLGSDTPFDEKQVKIGRRLLTKLWNASRFVL-HFSADPEPDKAEV---LEPLDRWILAKLAKVVEKATEAL 630
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 799 LSRELSLVTHTLYHFWLHNLCDVYLEAVKPVLSSvpRPPGPPQ-----VLFSCADVGLRLLAPLMPFLAEELWQRLPPRp 873
Cdd:PRK13208 631 ENYDFAKALEEIESFFWHVFCDDYLELVKSRAYG--EDEEEEQksaryTLYTVLDTLLRLLAPFLPFITEEVWSWLYGG- 707
|
810 820 830 840
....*....|....*....|....*....|....*....|..
gi 160333671 874 ggplapSICVAPYPSTRslEFWRQPELERCFSRVQEVVQALR 915
Cdd:PRK13208 708 ------SVHRASWPEPD--EELIDEEDEELGELAKEILSAVR 741
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
145-919 |
1.41e-83 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 291.21 E-value: 1.41e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 145 PPNVTGSLHIGHALTVAIQDALVRWHRMRGDRVLWIPGSD-HaG--IATQamVEKQLwKEQRVRRHELSREDFLRA---- 217
Cdd:COG0060 54 PPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGWDcH-GlpIELK--VEKEL-GIKKKDIEKVGIAEFREKcrey 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 218 VWQWKHE-KggeiyEQLCALGASLDWDRECFTMDAGSSAAVTEAFVRLYNSGLLYRNRQLVNWSCTLRSAISDIEVESRP 296
Cdd:COG0060 130 ALKYVDEqR-----EDFKRLGVWGDWDNPYLTMDPEYEESIWWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEVEYKD 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 297 LPGRTVlqlpgcptpvsfgllaSVAFPVDGEP------DTEIVVGTTRPETLPGDVAVAVHPD---------DPRY---- 357
Cdd:COG0060 205 VTSPSI----------------YVKFPVKDEKalllleDAYLVIWTTTPWTLPANLAVAVHPDidyvlvevtGGERlila 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 358 ------------------------THLHGRQLRHPLTGQLL-----PLITDTtvqpHV----GTGAVKVTPAHSPIDAEI 404
Cdd:COG0060 269 ealveavlkelgiedyevlatfkgAELEGLRYEHPFYYVVGydrahPVILGD----YVttedGTGIVHTAPGHGEDDFEV 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 405 GTRHGLTPLSVIAEDGTMTSLCGDWlQGLHRFVAREKIMCTLREQG--LFRGLQEHPMvlPICSRSGDVVEYLLKSQWFV 482
Cdd:COG0060 345 GKKYGLPVLNPVDDDGRFTEEAPLF-AGLFVKDANPAIIEDLKERGalLAREKITHSY--PHCWRCKTPLIYRATPQWFI 421
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 483 RcqeMGDLAAKAVEsgALEL--W-PSFHQKSWQHWFAHIGDWCVSRQLWWGHQIPAYR------------VIG---ENAE 544
Cdd:COG0060 422 S---MDKLRDRALE--AIEKvnWiPEWGEGRFGNMLENRPDWCISRQRYWGVPIPIWVcedcgelhrteeVIGsvaELLE 496
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 545 DDRKECWVvgRSEAEARAVAAKRTGRPEAElTLERDPDVLDTWFSSALFPFSALgwpRETPDL---AHFYpltlLEtGSD 621
Cdd:COG0060 497 EEGADAWF--ELDLHRPFLDETLKCPKCGG-TMRRVPDVLDVWFDSGSMHFAVL---ENREELhfpADFY----LE-GSD 565
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 622 --------LLMfwvgrmvmLGTQLTGQLPFSKVLLHSMVRDRQGRKMSKSLGNVLDPRDIIsgqelqvlqaklrdgnldp 693
Cdd:COG0060 566 qtrgwfysSLL--------TSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVI------------------- 618
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 694 gelavaaaaqKKDfpygipecGTDALRFALCSHGiLGGDLHLSVSEVLNYRHFCNKLWNALRFVLRALgDNFVPQpAEEV 773
Cdd:COG0060 619 ----------DKY--------GADILRLWVASSD-YWGDLRFSDEILKEVRDVYRRLRNTYRFLLANL-DDFDPA-EDAV 677
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 774 TPSS--PMDAWILSRLAFAASECERGFLSRELSLVTHTLYHFwlhnlCDV-----YLEAVKPVL-----SSVPRppgppQ 841
Cdd:COG0060 678 PYEDlpELDRWILSRLNELIKEVTEAYDNYDFHRAYRALHNF-----CVEdlsnwYLDISKDRLyteaaDSLDRra-aqT 751
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 842 VLFSCADVGLRLLAPLMPFLAEELWQRLPprpgGPLAPSICVAPYPSTrsLEFWRQPELERCFSRVQEVV----QALRAL 917
Cdd:COG0060 752 TLYEVLETLVRLLAPILPFTAEEIWQNLP----GEAEESVHLADWPEV--DEELIDEELEAKWDLVREVRsavlKALEAA 825
|
..
gi 160333671 918 RA 919
Cdd:COG0060 826 RK 827
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
110-889 |
2.62e-52 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 199.61 E-value: 2.62e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 110 EAAWYQWWVREGFFKpeyqaRL-PQATGETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDRVLWIPGSDHAGI 188
Cdd:PLN02843 9 EPEIQKLWEENQVYK-----RVsDRNNGESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 189 ATQAMVEKQLWKEQR-----VRRHELSREDFLRAVWQWKhekggeiyEQLCALGASLDWDRECFTMDAGSSAAVTEAFVR 263
Cdd:PLN02843 84 PIELKVLQSLDQEARkeltpIKLRAKAAKFAKKTVDTQR--------ESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 264 LYNSGLLYRNRQLVNWSCTLRSAISDIEVE------SRPLpgrtVLQLPGCPTPVSFGLLASVAFPvdgepDTEIVVGTT 337
Cdd:PLN02843 156 MFLNGYIYRGRKPVHWSPSSRTALAEAELEypeghvSKSI----YVAFPVVSPSETSPEELEEFLP-----GLSLAIWTT 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 338 RPETLPGDVAVAVHPD----------------------DPRYTH------------------------------------ 359
Cdd:PLN02843 227 TPWTMPANAAVAVNDKlqysvvevqsfsedestsggnkKKRPGNvlkeqqklflivatdlvpaleakwgvklvvlktfpg 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 360 --LHGRQLRHPLTGQLLPLI-------TDTtvqphvGTGAVKVTPAHSPIDAEIGTRHGLTPLSVIAEDGTMTSLCGDwL 430
Cdd:PLN02843 307 sdLEGCRYIHPLYNRESPVViggdyitTES------GTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQ-F 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 431 QGLHRFVAREKIMCT-LREQGLFrgLQEHPMV--LPICSRSGDVVEYLLKSQWFVRCQEMGDLAAKAVESgaLELWPSFH 507
Cdd:PLN02843 380 SGLSVLGEGNAAVVEaLDEAGSL--LMEEAYGhkYPYDWRTKKPTIFRATEQWFASVEGFRQAALDAIDK--VKWIPAQG 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 508 QKSWQHWFAHIGDWCVSRQLWWGHQIPAY-------------------RVIGENAEDdrkeCW----VVGRSEAEARAVA 564
Cdd:PLN02843 456 ENRIRAMVSGRSDWCISRQRTWGVPIPVFyhvetkeplmneetiahvkSIVAQKGSD----AWwymdVEDLLPEKYRDKA 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 565 AKrtgrpeaeltLERDPDVLDTWFSSALfpfSALGWPRETPDLAhfYPLTLLETGSDLLMFWVGRMVMLGTQLTGQLPFS 644
Cdd:PLN02843 532 SD----------YEKGTDTMDVWFDSGS---SWAGVLGSREGLS--YPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYK 596
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 645 KVLLHSMVRDRQGRKMSKSLGNVLDPRDIISGqelqvlqaklrdGNldpgelavaaaAQKKDfpygiPECGTDALRFALC 724
Cdd:PLN02843 597 SVLTHGFVLDEKGFKMSKSLGNVVDPRLVIEG------------GK-----------NQKQE-----PAYGADVLRLWVA 648
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 725 SHG-----ILGGDLHLSVSEVlnYRhfcnKLWNALRFVLRALGDnFVPQPAEEVTPSSPMDAWILSRLAFAASECERGFL 799
Cdd:PLN02843 649 SVDytgdvLIGPQILKQMSDI--YR----KLRGTLRYLLGNLHD-WKPDNAVPYEDLPSIDKYALFQLENVVNEIEESYD 721
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 800 SRELSLVTHTLYHFWLHNLCDVYLEAVKPVLSsVPRPPGPPQ-----VLFSCADVGLRLLAPLMPFLAEELWQRLPPRPG 874
Cdd:PLN02843 722 NYQFFKIFQILQRFTIVDLSNFYLDVAKDRLY-VGGTTSFTRrscqtVLAAHLLSLLRAIAPILPHLAEDAWQNLPFQED 800
|
890
....*....|....*
gi 160333671 875 GPLAPSICVAPYPST 889
Cdd:PLN02843 801 GSAAESVFEAGWPTP 815
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
735-869 |
1.55e-49 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 171.59 E-value: 1.55e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 735 LSVSEVLNYRHFCNKLWNALRFVLRALGDNFVPQPAEEvtPSSPMDAWILSRLAFAASECERGFLSRELSLVTHTLYHFW 814
Cdd:cd07962 1 FDEKRVEGGRNFCNKLWNAARFVLMNLEDDDEPEEDPE--SLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFF 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 160333671 815 LHNLCDVYLEAVKPVL--SSVPRPPGPPQVLFSCADVGLRLLAPLMPFLAEELWQRL 869
Cdd:cd07962 79 WNDFCDWYLELVKPRLygEDEEEKKAARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
138-674 |
2.05e-48 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 174.91 E-value: 2.05e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 138 TFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDRVLWIPGSDHAGIATQAMVEKQLWKEQRVRrhelSREDFLRA 217
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKKTI----WIEEFRED 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 218 VWQWKHEKGGEIYEQLCALGASLDWDRECFTMDAGSSAAVTEAFVRLYNSGLLYRnrqlvnwsctlrsaisdievesRPL 297
Cdd:cd00668 77 PKEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYR----------------------GTH 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 298 PGRtvlqlpgcPTPVSFgllasvafpvdgepdteivvgttrpetlpgdvavavhpddprythlhgrqlrhpltgqllpli 377
Cdd:cd00668 135 PVR--------ITEQWF--------------------------------------------------------------- 143
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 378 tdttvqphvgtgaVKVTPahspidaeigtrhgltplsviaedgtmtslcgdwlqglhrfvAREKIMctlreqglfRGLQE 457
Cdd:cd00668 144 -------------FDMPK------------------------------------------FKEKLL---------KALRR 159
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 458 HPMVLPicsrsgdvveyllksQWFVRCQEmgdlaakavesgalelwpsfhqkswqhWFAHIGDWCVSRQLWWGHQIPayr 537
Cdd:cd00668 160 GKIVPE---------------HVKNRMEA---------------------------WLESLLDWAISRQRYWGTPLP--- 194
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 538 vigenaeddrkecwvvgrseaearavaakrtgrpeaeltlerdPDVLDTWFSSALFPFSALGWPRETPDLAHFYPLTLLE 617
Cdd:cd00668 195 -------------------------------------------EDVFDVWFDSGIGPLGSLGYPEEKEWFKDSYPADWHL 231
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*..
gi 160333671 618 TGSDLLMFWVGRMVMLGTQLTGQLPFSKVLLHSMVRDRQGRKMSKSLGNVLDPRDII 674
Cdd:cd00668 232 IGKDILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVV 288
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
780-928 |
1.59e-33 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 125.98 E-value: 1.59e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 780 DAWILSRLAFAASECERGFLSRELSLVTHTLYHFWLHNLCDVYLEAVKPVLSSVPRPPGPPQVLFSCADVGLRLLAPLMP 859
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEEPDSRAQTTLYEVLETLLRLLAPFMP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 160333671 860 FLAEELWQRLpprpggplapSICVAPYPSTRSLEfwrQPELERCFSRVQEVVQALRALRATYQLTKARP 928
Cdd:pfam08264 81 FITEELWQKE----------SIHLAPWPEDAELE---EAELEEAFELRQEIVQAIRKLRSELKIKKSLP 136
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
145-918 |
3.43e-29 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 126.38 E-value: 3.43e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 145 PPNVTGSLHIGHALTVAIQDALVRWHRMRGDRVLWIPGSDHAGIATQAMVEKQLWKEQRV--------RRHELSREDFLR 216
Cdd:PLN02882 46 PPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHGLPVEYEIDKKLGIKRRDdvlkmgidKYNEECRSIVTR 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 217 AVWQWkhEKggeiyeQLCALGASLDWDRECFTMDAGSSAAVTEAFVRLYNSGLLYRNRQLVNWSCTLRSAISDIEVEsrp 296
Cdd:PLN02882 126 YSKEW--EK------TVTRTGRWIDFENDYKTMDPKFMESVWWVFKQLFEKGLVYKGFKVMPYSTACKTPLSNFEAG--- 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 297 LPGRTVlqlpgcPTPVsfgllASVAFPVDGEPD-TEIVVGTTRPETLPGDVAVAVHPD------------------DPRY 357
Cdd:PLN02882 195 LNYKDV------SDPA-----VMVSFPIVGDPDnASFVAWTTTPWTLPSNLALCVNPNftyvkvrnkytgkvyivaESRL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 358 THL-----------------HGRQLRHPLTGQLL------PL--------------ITDTTVQPHVGTGAVKVTPAHSPI 400
Cdd:PLN02882 264 SALptakpkskkgskpenaaEGYEVLAKVPGSSLvgkkyePLfdyfsefsdtafrvVADDYVTDDSGTGVVHCAPAFGED 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 401 DAEIGTRHGLT------PLSVIAeDGTMTSLCGDWlQGLHRFVAREKIMCTLREQGlfRGLQEHPMV--LPICSRSGDVV 472
Cdd:PLN02882 344 DYRVCLANGIIekggnlPVPVDD-DGCFTEKVTDF-SGRYVKDADKDIIAAIKAKG--RLVKSGSIThsYPFCWRSDTPL 419
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 473 EYLLKSQWFVRCQEMGDlaaKAVESGALELW-PSF-HQKSWQHWFAHIGDWCVSRQLWWGHQIPAYrvigenAEDDRKEC 550
Cdd:PLN02882 420 IYRAVPSWFVKVEEIKD---RLLENNKQTYWvPDYvKEKRFHNWLENARDWAVSRSRFWGTPLPIW------ISDDGEEV 490
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 551 WVVGrSEAEARAVAAKR---------------TGRPEAELTLERDPDVLDTWFSSALFPFSALGWPRETPDLahF---YP 612
Cdd:PLN02882 491 VVIG-SIAELEKLSGVKvtdlhrhfidhitipSSRGPEFGVLRRVDDVFDCWFESGSMPYAYIHYPFENKEL--FeknFP 567
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 613 LTLLETGSDLLMFWVGRMVMLGTQLTGQLPFSKVLLHSMVRDRQGRKMSKSLGNVLDPRDIISgqelqvlqaklrdgnld 692
Cdd:PLN02882 568 ADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVID----------------- 630
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 693 pgelavaaaaqkkdfpygipECGTDALRFALC-------------SHGILGgdlhlSVSEVL-----NYRHFcnkLWNAL 754
Cdd:PLN02882 631 --------------------KYGADALRLYLInspvvraeplrfkEEGVFG-----VVKDVFlpwynAYRFL---VQNAK 682
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 755 RFVLRAlGDNFVPQPAEEVTPSS-PMDAWILSrlafaASECERGFLSRE-----LSLVTHTLYHFwLHNLCDVYleavkp 828
Cdd:PLN02882 683 RLEVEG-GAPFVPLDLAKLQNSAnVLDRWINS-----ATQSLVKFVREEmgayrLYTVVPYLVKF-IDNLTNIY------ 749
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 829 VLSSVPRPPGPP---------QVLFSCADVGLRLLAPLMPFLAEELWQRL-PPRPGGPlaPSICVAPYPSTRSLEfwRQP 898
Cdd:PLN02882 750 VRFNRKRLKGRTgeedcrtalSTLYNVLLTSCKVMAPFTPFFTEVLYQNLrKVLPGSE--ESIHYCSFPQVDEGE--LDE 825
|
890 900
....*....|....*....|
gi 160333671 899 ELERCFSRVQEVVQALRALR 918
Cdd:PLN02882 826 RIEQSVSRMQTVIELARNIR 845
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
104-874 |
4.38e-28 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 122.17 E-value: 4.38e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 104 YSPQYVEAAWYQWWVREGFFKPEYQARLPQATgeTFSMcIPPPnvTGSLHIGHALTVAIQDALVRWHRMRGDRVLWIPGS 183
Cdd:TIGR00396 1 YNHIEIEEKWQQKWDENKTFKVTDDSSKPKYY--ILSM-FPYP--SGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGW 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 184 DHAGI-ATQAMVEKQLwkeqrvrrhelsredflrAVWQWKHEKGGEIYEQLCALGASLDWDRECFTMDAGSSAAVTEAFV 262
Cdd:TIGR00396 76 DAFGLpAENAAIKRGI------------------HPAKWTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIFL 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 263 RLYNSGLLYRNRQLVNWSCTL-------------RSAISDIEVESRPLPgRTVL--------------QLPGCPTPV--- 312
Cdd:TIGR00396 138 ELFEKGLAYVKEADVNWCPNDgtvlaneqvdsdgRSWRGDTPVEKKELK-QWFLkitayaeellndleELDHWPESVkem 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 313 -------SFGllASVAFPVDGePDTEIVVGTTRPETLPGDVAVAVHPDDP-------------------RYTHLHGRQLR 366
Cdd:TIGR00396 217 qrnwigkSEG--VEITFKIAD-HDEKITVFTTRPDTIFGVTYLALAPEHPlvekaaennpkvaafikkiLNKTVAERTKA 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 367 --------------HPLTGQLLPLITDTTVQPHVGTGAVKVTPAHSPIDAEIGTRHGLTPLSVIAEDGTMTSLCGDWLQ- 431
Cdd:TIGR00396 294 tkekkgvdtgikaiHPLTGEKIPIWVANYVLMEYGTGAVMGVPAHDERDFEFAQKYGLPIKPVIDPAEKDLSLTAAYTEd 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 432 ----------GLHRFVAREKIMCTLREQGLfrglqehpmvlpicsrSGDVVEYLLKsqwfvrcqemgdlaakavesgale 501
Cdd:TIGR00396 374 gvlvnsgefnGLNSSEARNAIIDMLEKEGK----------------GKRKVNYRLR------------------------ 413
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 502 lwpsfhqkswqhwfahigDWCVSRQLWWGHQIP-------------------------AYRVIGENAEDDRKEcWVvgrs 556
Cdd:TIGR00396 414 ------------------DWGFSRQRYWGEPIPiihcedggvvpvpeedlpvilpedvVYDGDGGSPLSRIPE-WV---- 470
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 557 eaearavaakRTGRPEAELTLERDPDVLDTWFSSA--LFPFSALGWPRETPD---LAHFYPLTLLETGSD-----LLM-- 624
Cdd:TIGR00396 471 ----------NVTCPSCGKPALRETDTMDTFAGSSwyYLRYLDPKNTDGPFDkekAEYWLPVDLYIGGIEhailhLLYar 540
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 625 FWVGRMVMLGTqLTGQLPFSKVLLHSMV-----------------------RDRQGR--------KMSKSLGNVLDPRDI 673
Cdd:TIGR00396 541 FFHKFLRDIGY-VNTKEPFKKLINQGMVlgfyyppngkvpadvlterdekgKDKAGGelvyvgyeKMSKSKGNGIDPQEI 619
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 674 ISgqelqvlqaklrdgnldpgelavaaaaqkkdfpygipECGTDALRFALCSHGILGGDLHLSVSEVLNYRHFCNKLWNa 753
Cdd:TIGR00396 620 VE-------------------------------------SYGADALRLFIMFMGPIAASLEWNESGLEGARRFLDRVWN- 661
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 754 lrfvlraLGDNFVPQPAEEVTPSSPMDAwilsrlafAASECERGFlSRELSLVT-HTLYHFWLHNLCDVYLEAVKpVLSS 832
Cdd:TIGR00396 662 -------LVYEITGELDAASLTVTALEE--------AQKELRRDV-HKFLKKVTeDLEKRESFNTAISAMMELLN-KLYK 724
|
890 900 910 920
....*....|....*....|....*....|....*....|..
gi 160333671 833 VPRPPGPPQVLFSCadvgLRLLAPLMPFLAEELWQRLPPRPG 874
Cdd:TIGR00396 725 AKKEALMLEYLKGF----VTVLSPFAPHLAEELWEKLGSEPF 762
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
145-674 |
5.91e-26 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 110.40 E-value: 5.91e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 145 PPNVTGSLHIGHALTVAIQDALVRWHRMRGDRVLWIPGSDHAGIATQAMVEKQLWKEQRVRRHELSREDF--------LR 216
Cdd:cd00818 9 PPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEKMGIAEFnakcrefaLR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 217 AVWQWKhekggeiyEQLCALGASLDWDRECFTMDAGSSAAVTEAFVRLYNSGLLYRNRQLVNWsctlrsaisdievesrp 296
Cdd:cd00818 89 YVDEQE--------EQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW----------------- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 297 lpgrtvlqlpgcptpvsfgllasvafpvdgepdteivvgttrpetlpgdvavavhpddprythlhgrqlrhpltgqllPL 376
Cdd:cd00818 144 ------------------------------------------------------------------------------PL 145
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 377 ItdttvqphvgtgaVKVTPahspidaeigtrhgltplsviaedgtmtslcgdwlqglhrfvarekimctlreqglfrglq 456
Cdd:cd00818 146 I-------------YRATP------------------------------------------------------------- 151
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 457 ehpmvlpicsrsgdvveyllksQWFVRCQEMGDLAAKAVESgaLELWPSFHQKSWQHWFAHIGDWCVSRQLWWGHQIPAY 536
Cdd:cd00818 152 ----------------------QWFIRVTKIKDRLLEANDK--VNWIPEWVKNRFGNWLENRRDWCISRQRYWGTPIPVW 207
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 537 RvigenAEDDrkecwvvgrseaearavaakrtgrpeAELTLERDPDVLDTWFSSALFPFSALGWPRETPDLAHFYPLTLL 616
Cdd:cd00818 208 Y-----CEDC--------------------------GEVLVRRVPDVLDVWFDSGSMPYAQLHYPFENEDFEELFPADFI 256
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 160333671 617 ETGSDLLMFWVGRMVMLGTQLTGQLPFSKVLLHSMVRDRQGRKMSKSLGNVLDPRDII 674
Cdd:cd00818 257 LEGSDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKMSKSLGNYVDPQEVV 314
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
145-674 |
2.56e-25 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 113.91 E-value: 2.56e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 145 PPNVTGSLHIGHALTVAIQDALVRWHRMRGDRVLWIPGSDHAGIAtqamVEKQLWKEQRVRRhelsREDFLRAvwqwkhe 224
Cdd:PTZ00427 110 PPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLP----IEYEIEKENNINK----KEDILKM------- 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 225 kGGEIYEQLCA----------------LGASLDWDRECFTMDAGSSAAVTEAFVRLYNSGLLYRNRQLVNWSCTLRSAIS 288
Cdd:PTZ00427 175 -GIDVYNEKCRgivlkysnewvktverIGRWIDFKNDYKTMDKTFMESVWWVFSELYKNNYVYKSFKVMPYSCKCNTPIS 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 289 DIEVEsrplpgrtvLQLPGCPTP---VSFGLLASvaFPV---------DGEP---------------------------- 328
Cdd:PTZ00427 254 NFELN---------LNYKDTPDPsiiISFVLCSD--FPKveeecnieeDKQLlgekysvlynnkrensnngnnnstnnvc 322
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 329 ---DTEIVVGTTRPETLPGDVAVAVhpdDPRYTHL-----------------------------------------HGRQ 364
Cdd:PTZ00427 323 yaqHSEILAWTTTPWTLPSNLALCV---NEHFTYLrihhvksnrvvivgecrlewimkelkwnvedlkivnrfkgkELKG 399
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 365 LRH-PLTGQLL----------PLITDTTVQPHVGTGAVKVTPAHSPIDAEIGTRHG-LTPLSVIAED-----GTMTSLCg 427
Cdd:PTZ00427 400 LRYkPLFTNFYekynfkerayKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGvIDPEKNIFIDpldanGYFTNEV- 478
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 428 DWLQGLHRFVAREKIMCTLREQGlfRGLQEHPMV--LPICSRSGDVVEYLLKSQWFVRcqeMGDLAAKAVESGALELWPS 505
Cdd:PTZ00427 479 EEVQNLYIKEADNVIKKKLKNEN--RLLSNNTIVhsYPFCWRSDTPLIYRAIPAWFIR---VSNSTNELVKNNETTYWIP 553
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 506 FH--QKSWQHWFAHIGDWCVSRQLWWGHQIPAYrvigenaEDDRKECWVVGRSEAEARAVAAKRT--------------G 569
Cdd:PTZ00427 554 AHikEKKFHNWIKDAKDWCISRNRYWGTPIPIW-------ADEKMETVICVESIKHLEELSGVKNindlhrhfidhieiK 626
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 570 RPEAEL--TLERDPDVLDTWFSSALFPFSALGWP--RETPDLAHFYPLTLLETGSDLLMFWVGRMVMLGTQLTGQLPFSK 645
Cdd:PTZ00427 627 NPKGKTypKLKRIPEVFDCWFESGSMPYAKVHYPfsTEKEDFHKIFPADFIAEGLDQTRGWFYTLLVISTLLFDKAPFKN 706
|
650 660
....*....|....*....|....*....
gi 160333671 646 VLLHSMVRDRQGRKMSKSLGNVLDPRDII 674
Cdd:PTZ00427 707 LICNGLVLASDGKKMSKRLKNYPDPLYIL 735
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
152-869 |
1.01e-21 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 101.87 E-value: 1.01e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 152 LHIGHALTVAIQDALVRWHRMRGDRVLWiPGSDHA------GIAtqamvekqlwkeQRVRRHELSREDFLRAVwqwkHEK 225
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLF-PMAFHVtgtpilGIA------------ERIARGDPETIELYKSL----YGI 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 226 GGEIYEQLC------------------ALGASLDWDRECFTMDAGSSAAVTEAFVRLYNSGLLYRNRQLVNWsCTLrsai 287
Cdd:PRK12300 64 PEEELEKFKdpeyiveyfseeakedmkRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRY-CPN---- 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 288 SDIEVESRPLPGRTVlqlpgcPTPVSFGLlasVAFPVDGepDTEIVVGTTRPETLPGDVAVAVHPD-------------- 353
Cdd:PRK12300 139 DNNPVGDHDLLDGEE------PEIVEYTL---IKFEESE--DLILPAATLRPETIFGVTNLWVNPDatyvkaevdgekwi 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 354 --------------------DPRYTHLHGRQLRHPLTGQLLPLITDTTVQPHVGTGAVKVTPAHSPID--------AEIG 405
Cdd:PRK12300 208 vskeaaeklsfqdrdveiieEIKGSELIGKKVKNPVTGKEVPILPADFVDPDNGTGVVMSVPAHAPYDyvalrdlkKNKE 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 406 TRHGLTPLSVI---------AED-----------------------------GTMTSLCGDwLQGLHRFVAREKIMCTLR 447
Cdd:PRK12300 288 LLDVIEPIPLIevegygefpAKEvveklgiksqedpeleeatkevyraefhkGVLKENTGE-YAGKPVREAREKITKDLI 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 448 EQGLFRGLQEHpMVLPICSRSG-DVVEYLLKSQWFVRC--QEMGDLAAKAVESgaLELWPS-----FHQK-SWqhwfahI 518
Cdd:PRK12300 367 EKGIADIMYEF-SNRPVYCRCGtECVVKVVKDQWFIDYsdPEWKELAHKALDN--MEIIPEeyrkeFENTiDW------L 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 519 GDWCVSRQLWWGHQIP-----------------AY-------RVIGENAEDDRKECW---VVGRSEAEAravAAKRTGRP 571
Cdd:PRK12300 438 KDRACARRRGLGTRLPwdeewiieslsdstiymAYytiahkiREYGIKPEQLTPEFFdyvFLGKGDPEE---VSKKTGIP 514
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 572 EAELTLERDpdvldtwfssalfpfsalgwpretpDLAHFYPLTLLETGSDL----LMF-------------WVGRMVMLG 634
Cdd:PRK12300 515 KEILEEMRE-------------------------EFLYWYPVDWRHSGKDLipnhLTFfifnhvaifpeekWPRGIVVNG 569
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 635 tqltgqlpfskvllhsMVRdRQGRKMSKSLGNVLDPRDIISgqelqvlqaklrdgnldpgelavaaaaqkkdfpygipEC 714
Cdd:PRK12300 570 ----------------FVL-LEGKKMSKSKGNVIPLRKAIE-------------------------------------EY 595
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 715 GTDALRFALCSHGILGGDLHLSVSEVLNYRHFCNKLWNalrFVLRALGdnfvpqpAEEVTPSSPMDAWILSRLAFA---A 791
Cdd:PRK12300 596 GADVVRLYLTSSAELLQDADWREKEVESVRRQLERFYE---LAKELIE-------IGGEEELRFIDKWLLSRLNRIikeT 665
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 792 SECERGFLSRELslVTHTLYHfwLHNLCDVYL----EAVKPVLSSVprppgppqvlfscADVGLRLLAPLMPFLAEELWQ 867
Cdd:PRK12300 666 TEAMESFQTRDA--VQEAFYE--LLNDLRWYLrrvgEANNKVLREV-------------LEIWIRLLAPFTPHLAEELWH 728
|
..
gi 160333671 868 RL 869
Cdd:PRK12300 729 KL 730
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
91-450 |
1.04e-18 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 92.19 E-value: 1.04e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 91 GEKKDVSGPLPPAYSPQYVEAAWYQWWVREGFFKPEYQARLPQATGETFSMcIPPPNVTGsLHIGHALTVAIQDALVRWH 170
Cdd:PLN02563 67 STTAKTTPAAKRAYPFHEIEPKWQRYWEENRTFRTPDDVDTSKPKFYVLDM-FPYPSGAG-LHVGHPEGYTATDILARYK 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 171 RMRGDRVLWIPGSDHAGI-ATQAMVEkqlwkeqrVRRHelSREDFLRAVWQWKhekggeiyEQLCALGASLDWDRECFTM 249
Cdd:PLN02563 145 RMQGYNVLHPMGWDAFGLpAEQYAIE--------TGTH--PKITTLKNIARFR--------SQLKSLGFSYDWDREISTT 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 250 DAGSSAAVTEAFVRLYNSGLLYRNRQLVNWSCTLRSAISDIE------------VESRPL----------PGRTVLQLPG 307
Cdd:PLN02563 207 EPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCPALGTVLANEEvvdglsergghpVIRKPMrqwmlkitayADRLLEDLDD 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 308 CPTPVSFGLL----------ASVAFPVDG----EPDTEIVVGTTRPETLPGDVAVAVHPDDP------------------ 355
Cdd:PLN02563 287 LDWPESIKEMqrnwigrsegAELDFSVLDgegkERDEKITVYTTRPDTLFGATYLVVAPEHPllsslttaeqkeaveeyv 366
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 356 ----RYTHLHGRQL-------------RHPLTGQLLPLITDTTVQPHVGTGAVKVTPAHSPIDAEIGTRHGLTPLSVIA- 417
Cdd:PLN02563 367 daasRKSDLERTELqkektgvftgsyaINPATGEAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKp 446
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 160333671 418 -------------EDGTM--TSLCGDWLQGLHRFVAREKIMCTLREQG 450
Cdd:PLN02563 447 adgneddaekaytGEGVIvnSSSSGLDINGLSSKEAAKKVIEWLEETG 494
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
104-887 |
2.60e-18 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 90.50 E-value: 2.60e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 104 YSPQYVEAAWYQWWVREGFFKPEyqarlPQATGETF---SMcIPPPnvTGSLHIGHALTVAIQDALVRWHRMRGDRVL-- 178
Cdd:COG0495 5 YNPKEIEKKWQKYWEENGTFKAD-----EDSSKPKYyvlDM-FPYP--SGRLHMGHVRNYTIGDVVARYKRMQGYNVLhp 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 179 --W----IPgsdhagiATQAMVEKQlwkeqrvrRHElsredflrAVWQWK---HEKggeiyEQLCALGASLDWDRECFTM 249
Cdd:COG0495 77 mgWdafgLP-------AENAAIKNG--------VHP--------AEWTYEniaNMR-----RQLKRLGLSYDWSREIATC 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 250 DagssaavtEA--------FVRLYNSGLLYRNRQLVNW--SC-T-L--------RSAISDIEVESRPLPG---------- 299
Cdd:COG0495 129 D--------PEyykwtqwiFLQLYEKGLAYRKEAPVNWcpVDqTvLaneqvidgRCWRCGAPVEKKELPQwflkitdyad 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 300 RtvL-----QLPGCPTPV----------SFGllASVAFPVDGePDTEIVVGTTRPETLPGD--VAVAV-HP-------DD 354
Cdd:COG0495 201 E--LlddldKLDGWPEKVktmqrnwigrSEG--AEVDFPVEG-SDEKITVFTTRPDTLFGAtfMVLAPeHPlvkelatPE 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 355 PR----------------------------YThlhGRQLRHPLTGQLLPL-ITDtTVQPHVGTGAVKVTPAHSPIDAEIG 405
Cdd:COG0495 276 QNaavaafieeakkkseiertsetkektgvFT---GLYAINPLTGEKIPIwIAD-YVLMDYGTGAVMAVPAHDQRDFEFA 351
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 406 TRHGLTPLSVIA---------------EDGTMT-SlcgDWLQGLHRFVAREKIMCTLREQGLFRGlqehpmvlpicsrsg 469
Cdd:COG0495 352 KKYGLPIKQVIApedgddpdileeaytGDGVLInS---GEFDGLDSEEAKEAIIEWLEEKGLGKR--------------- 413
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 470 dVVEYLLKsqwfvrcqemgdlaakavesgalelwpsfhqkswqhwfahigDWCVSRQLWWGHQIP--------------- 534
Cdd:COG0495 414 -KVNYRLR------------------------------------------DWLISRQRYWGEPIPiihcedcgvvpvped 450
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 535 ----------AYRVIGENAEDDRKEcWVvgrseaearAVAAKRTGRPeAeltlERDPDVLDTWF-SSalfpfsalgW--- 600
Cdd:COG0495 451 qlpvelpedvDFDPTGGSPLARAPE-WV---------NVTCPKCGGP-A----RRETDTMDTFVdSS---------Wyyl 506
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 601 ----PRET-----PDLAHFY-PLtlletgsDL-----------LM---FWVgrMVM--LGtQLTGQLPFSKVLLHSMVRD 654
Cdd:COG0495 507 rytdPHNDeapfdPEAANYWlPV-------DQyiggiehailhLLyarFFT--KVLrdLG-LVSFDEPFKRLLTQGMVLE 576
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 655 --RQGR------KMSKSLGNVLDPRDIISgqelqvlqaklrdgnldpgelavaaaaqkkdfpygipECGTDALR----FA 722
Cdd:COG0495 577 vgKDGVviggieKMSKSKGNVVDPDEIIE-------------------------------------KYGADTLRlfemFA 619
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 723 lcshgilgGDLHLSVSevlnyrhfcnklWN------ALRFVLRA--LGDNFVPQPAEEVTPSSPMDAWI----------- 783
Cdd:COG0495 620 --------GPPERDLE------------WSdsgvegAYRFLNRVwrLVVDEAEALKLDVADLSEADKELrralhktikkv 679
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 784 ---LSRLAF--AASECergflsRELslvTHTLYHFWLHNLCD--VYLEAVKPVlssvprppgppqvlfscadvgLRLLAP 856
Cdd:COG0495 680 tedIERLRFntAIAAL------MEL---VNALYKAKDSGEADraVLREALETL---------------------VLLLAP 729
|
970 980 990
....*....|....*....|....*....|.
gi 160333671 857 LMPFLAEELWQRLpprpGGplAPSICVAPYP 887
Cdd:COG0495 730 FAPHIAEELWERL----GH--EGSVADAPWP 754
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
736-918 |
7.60e-18 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 82.19 E-value: 7.60e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 736 SVSEvlNYRhfcnKLWNALRFVLRALGDnfvPQPAEEVTPSSPM---DAWILSRLAFAASECERGFLSRELSLVTHTLYH 812
Cdd:cd07960 8 QVAE--AYR----KIRNTFRFLLGNLND---FDPAKDAVPYEELlelDRYALHRLNELIKEVREAYENYEFHKVYQALNN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 813 FWLHNLCDVYLEAVKPVL-----SSVPRPPGppQ-VLFSCADVGLRLLAPLMPFLAEELWQRLPPRPGgplAPSICVAPY 886
Cdd:cd07960 79 FCTVDLSAFYLDIIKDRLycdakDSLERRSA--QtVLYHILDALLKLLAPILPFTAEEVWEHLPGEKK---EESVFLEDW 153
|
170 180 190
....*....|....*....|....*....|..
gi 160333671 887 PSTRslEFWRQPELErcfsrvqEVVQALRALR 918
Cdd:cd07960 154 PELP--EEWKDEELE-------EKWEKLLALR 176
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
737-915 |
2.85e-17 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 80.67 E-value: 2.85e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 737 VSEVLnyRHFCNKLWNALRF-VLRALGDNFVPQPAEEVTPSSP-MDAWILSRLAFAASECERGFLSRELSLVTHTLYHFW 814
Cdd:cd07961 6 VREVV--RKVLLPLWNAYRFfVTYANLDGFDPGKDDDAVASLNvLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEFI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 815 LhNLCDVYL------------EAVKpvLSSVprppgppQVLFSCADVGLRLLAPLMPFLAEELWQRLppRPGGPLAP-SI 881
Cdd:cd07961 84 D-ELTNWYIrrnrkrfwgeegDDDK--LAAY-------ATLYEVLLTLSRLMAPFTPFITEEIYQNL--RRELGDAPeSV 151
|
170 180 190
....*....|....*....|....*....|....
gi 160333671 882 CVAPYPSTRslEFWRQPELERCFSRVQEVVQALR 915
Cdd:cd07961 152 HLLDWPEVD--ESLIDEELEEAMELVREIVELGR 183
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
144-279 |
5.34e-13 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 71.12 E-value: 5.34e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 144 PPPNvtGSLHIGHALTVAIQDALVRWHRMRGDRVLWIPGSDHAGIATQAMVEkqlwkeqRVRRHELSredflravwqWKH 223
Cdd:cd00812 9 PYPS--GALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAI-------KIGRDPED----------WTE 69
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 160333671 224 EKGGEIYEQLCALGASLDWDRECFTMDAGSSAAVTEAFVRLYNSGLLYRNRQLVNW 279
Cdd:cd00812 70 YNIKKMKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNW 125
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
146-214 |
9.27e-09 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 58.84 E-value: 9.27e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 160333671 146 PNVTGSLHIGHALTVAIQDALVRWHRMRGDRVLWIPGSDHAG--IATQAMVEKQLWKEQRVRRHELSREDF 214
Cdd:pfam09334 8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGtpIELKAEKEGITPEELVDRYHEIHREDF 78
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
143-200 |
1.11e-08 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 58.97 E-value: 1.11e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 160333671 143 IPPPNvtGSLHIGHALTVaIQ-DALVRWHRMRGDRVLWIPGSD-H----------AGIATQAMVE------KQLWK 200
Cdd:COG0143 9 IPYAN--GPPHIGHLYTY-IPaDILARYQRLRGHDVLFVTGTDeHgtkielaaekEGITPQELVDrihaefKELFE 81
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
657-869 |
2.09e-08 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 58.20 E-value: 2.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 657 GRKMSKSLGNVLDPRDIIsgqelqvlqaklrdgnldpgelavaaaaqkKDFpygipecGTDALRFALCSHGILGGDLHLS 736
Cdd:COG0143 325 GEKMSKSRGNVIDPDDLL------------------------------DRY-------GPDALRYYLLREVPFGQDGDFS 367
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 737 VSEVLNyRH---FCNKLWNalrFVLRALG------DNFVPQPAEEvtpsSPMDAWILSRLAFAASECERGFLSRELSLVT 807
Cdd:COG0143 368 WEDFVA-RVnsdLANDLGN---LASRTLSmihkyfDGKVPEPGEL----TEADEELLAEAEAALEEVAEAMEAFEFRKAL 439
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 160333671 808 HTLYHFWlhNLCDVYLEAVKP-VLSSVPRPPGPPQVLFSCADVgLR----LLAPLMPFLAEELWQRL 869
Cdd:COG0143 440 EEIMALA--RAANKYIDETAPwKLAKDEDPERLATVLYTLLEA-LRilaiLLKPFLPETAEKILEQL 503
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
146-271 |
2.11e-08 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 57.16 E-value: 2.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 146 PNVTGSLHIGHALTVAIQDALVRWHRMRGDRVLWIPGSDHAG--IATQAMVEKQLWKEQRVRRHELSREDflravWQWkh 223
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGtkIEQKAEEEGVTPQELCDKYHEIFKDL-----FKW-- 81
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 160333671 224 ekggeiyeqlcalgASLDWDRECFTMDAGSSAAVTEAFVRLYNSGLLY 271
Cdd:cd00814 82 --------------LNISFDYFIRTTSPRHKEIVQEFFKKLYENGYIY 115
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
137-237 |
2.43e-08 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 57.97 E-value: 2.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 137 ETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDRVLWIPGSD-H----------AGIATQAMVE------KQLW 199
Cdd:PRK11893 1 KKFYITTPIYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDeHgqkiqrkaeeAGISPQELADrnsaafKRLW 80
|
90 100 110
....*....|....*....|....*....|....*....
gi 160333671 200 KeqrvrRHELSREDFLRAVwQWKHEKG-GEIYEQLCALG 237
Cdd:PRK11893 81 E-----ALNISYDDFIRTT-DPRHKEAvQEIFQRLLANG 113
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
580-869 |
2.53e-07 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 54.50 E-value: 2.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 580 DPD-VLDTWFSsALFPF-SALGWP----RETPDLAHFYP--LTLLetGSDLLMF----WVGRMVMLGtqltGQLPfSKVL 647
Cdd:PRK11893 217 DPKhVIYVWFD-ALTNYlTALGYPddeeLLAELFNKYWPadVHLI--GKDILRFhavyWPAFLMAAG----LPLP-KRVF 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 648 LHSMVRdRQGRKMSKSLGNVLDPRDIISgqelqvlqaklrdgnldpgelavaaaaqkkdfpygipECGTDALRFALCSHG 727
Cdd:PRK11893 289 AHGFLT-LDGEKMSKSLGNVIDPFDLVD-------------------------------------EYGVDAVRYFLLREI 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 728 ILGGDLHLSVSEVLNYR--HFCNKLWNALRFVLRALGDNF---VPQPAEEvtpsSPMDAWILSRLAFAASECERGFLSRE 802
Cdd:PRK11893 331 PFGQDGDFSREAFINRInaDLANDLGNLAQRTLSMIAKNFdgkVPEPGAL----TEADEALLEAAAALLERVRAAMDNLA 406
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 160333671 803 LSLVTHTLYHfwLHNLCDVYLEAVKPVLSSVPRPPGPPQVLFSCADvGLR----LLAPLMPFLAEELWQRL 869
Cdd:PRK11893 407 FDKALEAILA--LVRAANKYIDEQAPWSLAKTDPERLATVLYTLLE-VLRgiavLLQPVMPELAAKILDQL 474
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
476-674 |
3.67e-07 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 53.41 E-value: 3.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 476 LKSQWFVR--CQEMGDLAAKAVEsgALELWPSFHQKSWQHWfahIGdwcVSRQLWWGHQIPAYRVIgenaeddrkECWVv 553
Cdd:cd00812 128 LLDQWFLKysETEWKEKLLKDLE--KLDGWPEEVRAMQENW---IG---CSRQRYWGTPIPWTDTM---------ESLS- 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 554 GRSEAEARAVAAKRTGRPEaELTLERDPDVLDTWfssalfpfsalgwpretpdlahfYPLTLLETGSDL----LMFWV-G 628
Cdd:cd00812 190 DSTWYYARYTDAHNLEQPY-EGDLEFDREEFEYW-----------------------YPVDIYIGGKEHapnhLLYSRfN 245
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 160333671 629 RMVMLGTQLTGQLPFSKVLLHSMVRdRQGRKMSKSLGNVLDPRDII 674
Cdd:cd00812 246 HKALFDEGLVTDEPPKGLIVQGMVL-LEGEKMSKSKGNVVTPDEAI 290
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
148-216 |
5.69e-07 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 53.65 E-value: 5.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 148 VTGSLHIGHALTVAIQDALVRWHRMRGDRVLWIPGSD-H----------AGIATQAMVE------KQLWKEQrvrrhELS 210
Cdd:PRK12267 15 PNGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDeHgqkiqqaaekAGKTPQEYVDeisagfKELWKKL-----DIS 89
|
....*.
gi 160333671 211 REDFLR 216
Cdd:PRK12267 90 YDKFIR 95
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
146-214 |
6.71e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 50.15 E-value: 6.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 146 PNVTGSLHIGHALTVaIQ-DALVRWHRMRGDRVLWIPGSD-H----------AGIATQAMVEkqlwkeqrvRRHELSRED 213
Cdd:PRK00133 11 PYANGPIHLGHLVEY-IQaDIWVRYQRMRGHEVLFVCADDaHgtpimlkaekEGITPEELIA---------RYHAEHKRD 80
|
.
gi 160333671 214 F 214
Cdd:PRK00133 81 F 81
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
109-178 |
3.05e-05 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 48.14 E-value: 3.05e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 109 VEAAWYQWWVREGFFKPEYQARLPqATGETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDRVL 178
Cdd:PLN02959 18 IEVAVQKWWEEEKVFEAEAGDEPP-KPGEKFFGNFPYPYMNGLLHLGHAFSLSKLEFAAAYHRLRGANVL 86
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
136-272 |
3.05e-05 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 48.17 E-value: 3.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 136 GETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDRVLWIPGSDHAG--IATQAMVEKQLWKEQrvrrHELSRED 213
Cdd:PLN02224 68 ADTFVLTTPLYYVNAPPHMGSAYTTIAADSIARFQRLLGKKVIFITGTDEHGekIATSAAANGRNPPEH----CDIISQS 143
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 160333671 214 FlRAVWQwkhekggeiyeqlcalGASLDWDRECFTMDAGSSAAVTEAFVRLYNSGLLYR 272
Cdd:PLN02224 144 Y-RTLWK----------------DLDIAYDKFIRTTDPKHEAIVKEFYARVFANGDIYR 185
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
771-869 |
1.80e-04 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 42.19 E-value: 1.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 771 EEVTPSSPMDAWILSRLAFAASECERGFLSRELSLVTHTLYhFWLHNLCDVYLEAVKPVLSSvprppgppQVLFSCADVG 850
Cdd:cd07959 28 GELEELTFIDRWLLSRLNRLIKETTEAYENMQFREALKEGL-YELQNDLDWYRERGGAGMNK--------DLLRRFIEVW 98
|
90
....*....|....*....
gi 160333671 851 LRLLAPLMPFLAEELWQRL 869
Cdd:cd07959 99 TRLLAPFAPHLAEEIWHEL 117
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
851-869 |
4.27e-04 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 41.05 E-value: 4.27e-04
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
577-674 |
7.35e-04 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 43.64 E-value: 7.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333671 577 LERDPD-VLDTWFSsALFPF-SALGWPRETPDLAH-FYPLTLLETGSDLLMF----WVGRMVMLGtqltgqLPFSKVLL- 648
Cdd:PRK12267 217 VPFDPKhVVYVWID-ALLNYiTALGYGSDDDELFKkFWPADVHLVGKDILRFhaiyWPIMLMALG------LPLPKKVFa 289
|
90 100
....*....|....*....|....*..
gi 160333671 649 HS-MVRDrqGRKMSKSLGNVLDPRDII 674
Cdd:PRK12267 290 HGwWLMK--DGKMSKSKGNVVDPEELV 314
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
144-205 |
8.78e-04 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 40.93 E-value: 8.78e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 160333671 144 PPPNVTGSLHIGHALTVAIQDALVRWHRMRGDRVLWIPGSDHAG--IATQAMVEKQLWKEQRVR 205
Cdd:cd00802 4 SGITPNGYLHIGHLRTIVTFDFLAQAYRKLGYKVRCIALIDDAGglIGDPANKKGENAKAFVER 67
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
637-674 |
9.83e-04 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 42.78 E-value: 9.83e-04
10 20 30
....*....|....*....|....*....|....*....
gi 160333671 637 LTGQlPFSKVLLHS-MVRDRqGRKMSKSLGNVLDPRDII 674
Cdd:COG0215 244 ATGK-PFARYWMHNgFLTVN-GEKMSKSLGNFFTVRDLL 280
|
|
| ArgRS_core |
cd00671 |
catalytic core domain of arginyl-tRNA synthetases; Arginyl tRNA synthetase (ArgRS) catalytic ... |
146-178 |
2.35e-03 |
|
catalytic core domain of arginyl-tRNA synthetases; Arginyl tRNA synthetase (ArgRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. There are at least three subgroups of ArgRS. One type contains both characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. The second subtype lacks the KMSKS motif; however, it has a lysine N-terminal to the HIGH motif, which serves as the functional counterpart to the second lysine of the KMSKS motif. A third group, which is found primarily in archaea and a few bacteria, lacks both the KMSKS motif and the HIGH loop lysine.
Pssm-ID: 185675 [Multi-domain] Cd Length: 212 Bit Score: 40.63 E-value: 2.35e-03
10 20 30
....*....|....*....|....*....|...
gi 160333671 146 PNVTGSLHIGHALTVAIQDALVRWHRMRGDRVL 178
Cdd:cd00671 9 ANPTGPLHVGHLRNAIIGDSLARILEFLGYDVT 41
|
|
| argS |
PRK01611 |
arginyl-tRNA synthetase; Reviewed |
146-177 |
4.04e-03 |
|
arginyl-tRNA synthetase; Reviewed
Pssm-ID: 234964 [Multi-domain] Cd Length: 507 Bit Score: 40.91 E-value: 4.04e-03
10 20 30
....*....|....*....|....*....|..
gi 160333671 146 PNVTGSLHIGHALTVAIQDALVRWHRMRGDRV 177
Cdd:PRK01611 120 ANPTGPLHVGHLRSAVIGDALARILEFAGYDV 151
|
|
| |
