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Conserved domains on  [gi|575501678|ref|NP_780545|]
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tectonin beta-propeller repeat-containing protein 2 isoform 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tectonin super family cl41172
Tectonin domain; This entry represents proteins homologous to tectonin. This protein adopts a ...
 824-1018 4.80e-18

Tectonin domain; This entry represents proteins homologous to tectonin. This protein adopts a 6 bladed beta propeller structure.


The actual alignment was detected with superfamily member pfam19193:

Pssm-ID: 465992 [Multi-domain]  Cd Length: 215  Bit Score: 83.84  E-value: 4.80e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501678   824 QDALWALDSLGQVFIRTlskscptGMHWTKLDLSqlgtvrLTSL-ACGNQHIWACDSRGGVYFRVGTQPLNPSLmlPAWi 902
Cdd:pfam19193   43 PAGVWGVNSNNKIYKYV-------GGSWVPVDGS------LKQVdAGGDGQVWGVNSADDIYCLNGDDASSYAG--LPW- 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501678   903 mieppVQLAG-VTLVSVhsSPNDqmLWALDSRWNVHVRTGITEEMPVGTDWEHVPGlQACQLALSTR-TVWARCPNGDLA 980
Cdd:pfam19193  107 -----TQVDGsLKYYSC--GPGG--CWGVNSNDDIYYRRYVGPSTCGGTGWTQVPG-KLKMIEVGSDgSVFGVNSNGNVY 176

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 575501678   981 RRYGITDKNPAGDYWKKIPGSVSCFTVTSSD-ELWAVGS 1018
Cdd:pfam19193  177 QRTGISSSNPTGTGWTQIPGSLSIKHVSYDLgRLWGVNT 215
Hyd_WA pfam06462
Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from ...
 641-672 3.58e-05

Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from plasmodia of Physarum polycephalum (Slime mold) and both proteins contain six tandem repeats that are each 33-37 amino acids in length. Homologous repeats are found in L-6, a bacterial lipopolysaccharide-binding lectin from horseshoe crab hemocytes. The repetitive sequences of the tectonins and L-6 are reminiscent of the WD repeats of the beta-subunit of G proteins, suggesting that they form beta-propeller domains. The tectonins may be lectins that function as part of a transmembrane signalling complex during phagocytosis. Tectonin beta-propeller repeat-containing protein 1 (TECPR1) has a critical function during autophagosome maturation and autophagosome-lysosome fusion.


:

Pssm-ID: 461921 [Multi-domain]  Cd Length: 30  Bit Score: 41.63  E-value: 3.58e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 575501678   641 TLWALDIHGKLWFRTGVVPKKPQGddDHWWQV 672
Cdd:pfam06462    1 QVWAVTSDGRVYFRTGVTPSNPTG--TSWEHV 30
Hyd_WA pfam06462
Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from ...
 592-619 1.15e-04

Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from plasmodia of Physarum polycephalum (Slime mold) and both proteins contain six tandem repeats that are each 33-37 amino acids in length. Homologous repeats are found in L-6, a bacterial lipopolysaccharide-binding lectin from horseshoe crab hemocytes. The repetitive sequences of the tectonins and L-6 are reminiscent of the WD repeats of the beta-subunit of G proteins, suggesting that they form beta-propeller domains. The tectonins may be lectins that function as part of a transmembrane signalling complex during phagocytosis. Tectonin beta-propeller repeat-containing protein 1 (TECPR1) has a critical function during autophagosome maturation and autophagosome-lysosome fusion.


:

Pssm-ID: 461921 [Multi-domain]  Cd Length: 30  Bit Score: 40.09  E-value: 1.15e-04
                           10        20
                   ....*....|....*....|....*...
gi 575501678   592 VVWALTEQRALLYREGVSSFCPEGEQWK 619
Cdd:pfam06462    1 QVWAVTSDGRVYFRTGVTPSNPTGTSWE 28
 
Name Accession Description Interval E-value
Tectonin pfam19193
Tectonin domain; This entry represents proteins homologous to tectonin. This protein adopts a ...
 824-1018 4.80e-18

Tectonin domain; This entry represents proteins homologous to tectonin. This protein adopts a 6 bladed beta propeller structure.


Pssm-ID: 465992 [Multi-domain]  Cd Length: 215  Bit Score: 83.84  E-value: 4.80e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501678   824 QDALWALDSLGQVFIRTlskscptGMHWTKLDLSqlgtvrLTSL-ACGNQHIWACDSRGGVYFRVGTQPLNPSLmlPAWi 902
Cdd:pfam19193   43 PAGVWGVNSNNKIYKYV-------GGSWVPVDGS------LKQVdAGGDGQVWGVNSADDIYCLNGDDASSYAG--LPW- 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501678   903 mieppVQLAG-VTLVSVhsSPNDqmLWALDSRWNVHVRTGITEEMPVGTDWEHVPGlQACQLALSTR-TVWARCPNGDLA 980
Cdd:pfam19193  107 -----TQVDGsLKYYSC--GPGG--CWGVNSNDDIYYRRYVGPSTCGGTGWTQVPG-KLKMIEVGSDgSVFGVNSNGNVY 176

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 575501678   981 RRYGITDKNPAGDYWKKIPGSVSCFTVTSSD-ELWAVGS 1018
Cdd:pfam19193  177 QRTGISSSNPTGTGWTQIPGSLSIKHVSYDLgRLWGVNT 215
Hyd_WA pfam06462
Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from ...
 641-672 3.58e-05

Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from plasmodia of Physarum polycephalum (Slime mold) and both proteins contain six tandem repeats that are each 33-37 amino acids in length. Homologous repeats are found in L-6, a bacterial lipopolysaccharide-binding lectin from horseshoe crab hemocytes. The repetitive sequences of the tectonins and L-6 are reminiscent of the WD repeats of the beta-subunit of G proteins, suggesting that they form beta-propeller domains. The tectonins may be lectins that function as part of a transmembrane signalling complex during phagocytosis. Tectonin beta-propeller repeat-containing protein 1 (TECPR1) has a critical function during autophagosome maturation and autophagosome-lysosome fusion.


Pssm-ID: 461921 [Multi-domain]  Cd Length: 30  Bit Score: 41.63  E-value: 3.58e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 575501678   641 TLWALDIHGKLWFRTGVVPKKPQGddDHWWQV 672
Cdd:pfam06462    1 QVWAVTSDGRVYFRTGVTPSNPTG--TSWEHV 30
Hyd_WA pfam06462
Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from ...
 592-619 1.15e-04

Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from plasmodia of Physarum polycephalum (Slime mold) and both proteins contain six tandem repeats that are each 33-37 amino acids in length. Homologous repeats are found in L-6, a bacterial lipopolysaccharide-binding lectin from horseshoe crab hemocytes. The repetitive sequences of the tectonins and L-6 are reminiscent of the WD repeats of the beta-subunit of G proteins, suggesting that they form beta-propeller domains. The tectonins may be lectins that function as part of a transmembrane signalling complex during phagocytosis. Tectonin beta-propeller repeat-containing protein 1 (TECPR1) has a critical function during autophagosome maturation and autophagosome-lysosome fusion.


Pssm-ID: 461921 [Multi-domain]  Cd Length: 30  Bit Score: 40.09  E-value: 1.15e-04
                           10        20
                   ....*....|....*....|....*...
gi 575501678   592 VVWALTEQRALLYREGVSSFCPEGEQWK 619
Cdd:pfam06462    1 QVWAVTSDGRVYFRTGVTPSNPTGTSWE 28
TECPR smart00706
Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal ...
 993-1025 1.30e-04

Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins;


Pssm-ID: 214782 [Multi-domain]  Cd Length: 35  Bit Score: 40.17  E-value: 1.30e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 575501678    993 DYWKKIPGSVSCFTVTSSDELWAVGSSGCLLQR 1025
Cdd:smart00706    1 GSWTQVPGELVQVSVGPSDTVWAVNSDGNIYRR 33
TECPR smart00706
Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal ...
 630-656 7.08e-03

Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins;


Pssm-ID: 214782 [Multi-domain]  Cd Length: 35  Bit Score: 35.17  E-value: 7.08e-03
                            10        20
                    ....*....|....*....|....*..
gi 575501678    630 EPVCITLGDQHTLWALDIHGKLWFRTG 656
Cdd:smart00706    9 ELVQVSVGPSDTVWAVNSDGNIYRRTG 35
 
Name Accession Description Interval E-value
Tectonin pfam19193
Tectonin domain; This entry represents proteins homologous to tectonin. This protein adopts a ...
 824-1018 4.80e-18

Tectonin domain; This entry represents proteins homologous to tectonin. This protein adopts a 6 bladed beta propeller structure.


Pssm-ID: 465992 [Multi-domain]  Cd Length: 215  Bit Score: 83.84  E-value: 4.80e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501678   824 QDALWALDSLGQVFIRTlskscptGMHWTKLDLSqlgtvrLTSL-ACGNQHIWACDSRGGVYFRVGTQPLNPSLmlPAWi 902
Cdd:pfam19193   43 PAGVWGVNSNNKIYKYV-------GGSWVPVDGS------LKQVdAGGDGQVWGVNSADDIYCLNGDDASSYAG--LPW- 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501678   903 mieppVQLAG-VTLVSVhsSPNDqmLWALDSRWNVHVRTGITEEMPVGTDWEHVPGlQACQLALSTR-TVWARCPNGDLA 980
Cdd:pfam19193  107 -----TQVDGsLKYYSC--GPGG--CWGVNSNDDIYYRRYVGPSTCGGTGWTQVPG-KLKMIEVGSDgSVFGVNSNGNVY 176

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 575501678   981 RRYGITDKNPAGDYWKKIPGSVSCFTVTSSD-ELWAVGS 1018
Cdd:pfam19193  177 QRTGISSSNPTGTGWTQIPGSLSIKHVSYDLgRLWGVNT 215
Tectonin pfam19193
Tectonin domain; This entry represents proteins homologous to tectonin. This protein adopts a ...
 828-1037 4.83e-10

Tectonin domain; This entry represents proteins homologous to tectonin. This protein adopts a 6 bladed beta propeller structure.


Pssm-ID: 465992 [Multi-domain]  Cd Length: 215  Bit Score: 60.73  E-value: 4.83e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501678   828 WALDSLGQVFIRTLSKscptgmhWTKLDlsqlGtvRLTSLACGNQHIWACDSRGGVYFRVGTQplnpslmlpaWimiepp 907
Cdd:pfam19193   13 WGVDSAGNVYYLTGSS-------WVRVP----G--RLKHVSVGPAGVWGVNSNNKIYKYVGGS----------W------ 63

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501678   908 VQLAGvTLVSVHSSPnDQMLWALDSRWNVHVRTGITEEMPVGTDWEHVPGLQAcQLALSTRTVWARCPNGDLARRYGITD 987
Cdd:pfam19193   64 VPVDG-SLKQVDAGG-DGQVWGVNSADDIYCLNGDDASSYAGLPWTQVDGSLK-YYSCGPGGCWGVNSNDDIYYRRYVGP 140

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 575501678   988 KNPAGDYWKKIPGSVSCFTVTSSDELWAVGSSGCLLQRLTKTFShshNPQ 1037
Cdd:pfam19193  141 STCGGTGWTQVPGKLKMIEVGSDGSVFGVNSNGNVYQRTGISSS---NPT 187
Hyd_WA pfam06462
Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from ...
 926-955 7.17e-07

Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from plasmodia of Physarum polycephalum (Slime mold) and both proteins contain six tandem repeats that are each 33-37 amino acids in length. Homologous repeats are found in L-6, a bacterial lipopolysaccharide-binding lectin from horseshoe crab hemocytes. The repetitive sequences of the tectonins and L-6 are reminiscent of the WD repeats of the beta-subunit of G proteins, suggesting that they form beta-propeller domains. The tectonins may be lectins that function as part of a transmembrane signalling complex during phagocytosis. Tectonin beta-propeller repeat-containing protein 1 (TECPR1) has a critical function during autophagosome maturation and autophagosome-lysosome fusion.


Pssm-ID: 461921 [Multi-domain]  Cd Length: 30  Bit Score: 46.25  E-value: 7.17e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 575501678   926 MLWALDSRWNVHVRTGITEEMPVGTDWEHV 955
Cdd:pfam06462    1 QVWAVTSDGRVYFRTGVTPSNPTGTSWEHV 30
Hyd_WA pfam06462
Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from ...
 969-998 1.11e-06

Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from plasmodia of Physarum polycephalum (Slime mold) and both proteins contain six tandem repeats that are each 33-37 amino acids in length. Homologous repeats are found in L-6, a bacterial lipopolysaccharide-binding lectin from horseshoe crab hemocytes. The repetitive sequences of the tectonins and L-6 are reminiscent of the WD repeats of the beta-subunit of G proteins, suggesting that they form beta-propeller domains. The tectonins may be lectins that function as part of a transmembrane signalling complex during phagocytosis. Tectonin beta-propeller repeat-containing protein 1 (TECPR1) has a critical function during autophagosome maturation and autophagosome-lysosome fusion.


Pssm-ID: 461921 [Multi-domain]  Cd Length: 30  Bit Score: 45.87  E-value: 1.11e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 575501678   969 TVWARCPNGDLARRYGITDKNPAGDYWKKI 998
Cdd:pfam06462    1 QVWAVTSDGRVYFRTGVTPSNPTGTSWEHV 30
Hyd_WA pfam06462
Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from ...
 641-672 3.58e-05

Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from plasmodia of Physarum polycephalum (Slime mold) and both proteins contain six tandem repeats that are each 33-37 amino acids in length. Homologous repeats are found in L-6, a bacterial lipopolysaccharide-binding lectin from horseshoe crab hemocytes. The repetitive sequences of the tectonins and L-6 are reminiscent of the WD repeats of the beta-subunit of G proteins, suggesting that they form beta-propeller domains. The tectonins may be lectins that function as part of a transmembrane signalling complex during phagocytosis. Tectonin beta-propeller repeat-containing protein 1 (TECPR1) has a critical function during autophagosome maturation and autophagosome-lysosome fusion.


Pssm-ID: 461921 [Multi-domain]  Cd Length: 30  Bit Score: 41.63  E-value: 3.58e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 575501678   641 TLWALDIHGKLWFRTGVVPKKPQGddDHWWQV 672
Cdd:pfam06462    1 QVWAVTSDGRVYFRTGVTPSNPTG--TSWEHV 30
Hyd_WA pfam06462
Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from ...
 592-619 1.15e-04

Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from plasmodia of Physarum polycephalum (Slime mold) and both proteins contain six tandem repeats that are each 33-37 amino acids in length. Homologous repeats are found in L-6, a bacterial lipopolysaccharide-binding lectin from horseshoe crab hemocytes. The repetitive sequences of the tectonins and L-6 are reminiscent of the WD repeats of the beta-subunit of G proteins, suggesting that they form beta-propeller domains. The tectonins may be lectins that function as part of a transmembrane signalling complex during phagocytosis. Tectonin beta-propeller repeat-containing protein 1 (TECPR1) has a critical function during autophagosome maturation and autophagosome-lysosome fusion.


Pssm-ID: 461921 [Multi-domain]  Cd Length: 30  Bit Score: 40.09  E-value: 1.15e-04
                           10        20
                   ....*....|....*....|....*...
gi 575501678   592 VVWALTEQRALLYREGVSSFCPEGEQWK 619
Cdd:pfam06462    1 QVWAVTSDGRVYFRTGVTPSNPTGTSWE 28
TECPR smart00706
Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal ...
 993-1025 1.30e-04

Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins;


Pssm-ID: 214782 [Multi-domain]  Cd Length: 35  Bit Score: 40.17  E-value: 1.30e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 575501678    993 DYWKKIPGSVSCFTVTSSDELWAVGSSGCLLQR 1025
Cdd:smart00706    1 GSWTQVPGELVQVSVGPSDTVWAVNSDGNIYRR 33
Hyd_WA pfam06462
Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from ...
 826-854 1.97e-04

Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from plasmodia of Physarum polycephalum (Slime mold) and both proteins contain six tandem repeats that are each 33-37 amino acids in length. Homologous repeats are found in L-6, a bacterial lipopolysaccharide-binding lectin from horseshoe crab hemocytes. The repetitive sequences of the tectonins and L-6 are reminiscent of the WD repeats of the beta-subunit of G proteins, suggesting that they form beta-propeller domains. The tectonins may be lectins that function as part of a transmembrane signalling complex during phagocytosis. Tectonin beta-propeller repeat-containing protein 1 (TECPR1) has a critical function during autophagosome maturation and autophagosome-lysosome fusion.


Pssm-ID: 461921 [Multi-domain]  Cd Length: 30  Bit Score: 39.32  E-value: 1.97e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 575501678   826 ALWALDSLGQVFIRT-LSKSCPTGMHWTKL 854
Cdd:pfam06462    1 QVWAVTSDGRVYFRTgVTPSNPTGTSWEHV 30
TECPR smart00706
Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal ...
 630-656 7.08e-03

Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins;


Pssm-ID: 214782 [Multi-domain]  Cd Length: 35  Bit Score: 35.17  E-value: 7.08e-03
                            10        20
                    ....*....|....*....|....*..
gi 575501678    630 EPVCITLGDQHTLWALDIHGKLWFRTG 656
Cdd:smart00706    9 ELVQVSVGPSDTVWAVNSDGNIYRRTG 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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