NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|30425222|ref|NP_780686|]
View 

zinc finger protein 574 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
498-852 8.42e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 8.42e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425222 498 HKCSICGKMFKKKSHVRNHLRTHTGERPFPCPD--CSKPFNSPANLARHRLTHTGERPYRCgdCGKAFTQSSTLRQHRLV 575
Cdd:COG5048  34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425222 576 HAQHFPYR---CQECGVRFHRPYRLLMHRYHHTGEYPYKCRECPRSFLLR--RLLEVHQLVIHAGR-QPYRCSScgaaFP 649
Cdd:COG5048 112 SSSSNSNDnnlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqSNSLHPPLPANSLSkDPSSNLS----LL 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425222 650 SSLRLRehrcaaaaaQAPRRFECGTCGKKVGSAARLQAHEAAHAAAGPgevlakEPPAPRASRATRTPVAPSPTALSGTT 729
Cdd:COG5048 188 ISSNVS---------TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSS------LPLTTNSQLSPKSLLSQSPSSLSSSD 252

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425222 730 SAAPAAPARRRGPECSECKKLFSTETSLQVHRRIHTgerPYPCPDCGKAFRQSTHLKDHRR--LHTGE--RPFAC--EVC 803
Cdd:COG5048 253 SSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLC 329

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|.
gi 30425222 804 GKAFAISMRLAEHRRIHTGERPYSCP--DCGKSYRSFSNLWKHRKTHQQQH 852
Cdd:COG5048 330 GKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKD 380
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
498-852 8.42e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 8.42e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425222 498 HKCSICGKMFKKKSHVRNHLRTHTGERPFPCPD--CSKPFNSPANLARHRLTHTGERPYRCgdCGKAFTQSSTLRQHRLV 575
Cdd:COG5048  34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425222 576 HAQHFPYR---CQECGVRFHRPYRLLMHRYHHTGEYPYKCRECPRSFLLR--RLLEVHQLVIHAGR-QPYRCSScgaaFP 649
Cdd:COG5048 112 SSSSNSNDnnlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqSNSLHPPLPANSLSkDPSSNLS----LL 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425222 650 SSLRLRehrcaaaaaQAPRRFECGTCGKKVGSAARLQAHEAAHAAAGPgevlakEPPAPRASRATRTPVAPSPTALSGTT 729
Cdd:COG5048 188 ISSNVS---------TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSS------LPLTTNSQLSPKSLLSQSPSSLSSSD 252

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425222 730 SAAPAAPARRRGPECSECKKLFSTETSLQVHRRIHTgerPYPCPDCGKAFRQSTHLKDHRR--LHTGE--RPFAC--EVC 803
Cdd:COG5048 253 SSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLC 329

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|.
gi 30425222 804 GKAFAISMRLAEHRRIHTGERPYSCP--DCGKSYRSFSNLWKHRKTHQQQH 852
Cdd:COG5048 330 GKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKD 380
zf-H2C2_2 pfam13465
Zinc-finger double domain;
756-781 3.65e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 3.65e-05
                          10        20
                  ....*....|....*....|....*.
gi 30425222   756 SLQVHRRIHTGERPYPCPDCGKAFRQ 781
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
498-852 8.42e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 8.42e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425222 498 HKCSICGKMFKKKSHVRNHLRTHTGERPFPCPD--CSKPFNSPANLARHRLTHTGERPYRCgdCGKAFTQSSTLRQHRLV 575
Cdd:COG5048  34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425222 576 HAQHFPYR---CQECGVRFHRPYRLLMHRYHHTGEYPYKCRECPRSFLLR--RLLEVHQLVIHAGR-QPYRCSScgaaFP 649
Cdd:COG5048 112 SSSSNSNDnnlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqSNSLHPPLPANSLSkDPSSNLS----LL 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425222 650 SSLRLRehrcaaaaaQAPRRFECGTCGKKVGSAARLQAHEAAHAAAGPgevlakEPPAPRASRATRTPVAPSPTALSGTT 729
Cdd:COG5048 188 ISSNVS---------TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSS------LPLTTNSQLSPKSLLSQSPSSLSSSD 252

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425222 730 SAAPAAPARRRGPECSECKKLFSTETSLQVHRRIHTgerPYPCPDCGKAFRQSTHLKDHRR--LHTGE--RPFAC--EVC 803
Cdd:COG5048 253 SSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLC 329

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|.
gi 30425222 804 GKAFAISMRLAEHRRIHTGERPYSCP--DCGKSYRSFSNLWKHRKTHQQQH 852
Cdd:COG5048 330 GKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKD 380
zf-H2C2_2 pfam13465
Zinc-finger double domain;
756-781 3.65e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 3.65e-05
                          10        20
                  ....*....|....*....|....*.
gi 30425222   756 SLQVHRRIHTGERPYPCPDCGKAFRQ 781
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 761-846 4.45e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.02  E-value: 4.45e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425222 761 RRIHT-GERPYPCP--DCGKAFRQSTHLKDHRrLHTGERPFACEVCGKAfaismrlaEHRRIHTGERPYSCPDCGKSYRS 837
Cdd:COG5189 340 RMLKVkDGKPYKCPveGCNKKYKNQNGLKYHM-LHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKN 410


                ....*....
gi 30425222 838 FSNLWKHRK 846
Cdd:COG5189 411 LNGLKYHRK 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
768-840 4.59e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 4.59e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30425222 768 RPYPCPDCGKAFRQSTHLKDHRRLHTGERPFACEVCGKAFAISMRLA--EHRRIHTGERPYSCPDCGKSYRSFSN 840
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLElsRHLRTHHNNPSDLNSKSLPLSNSKAS 106
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
468-588 5.13e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 5.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425222 468 SYRCLLCSREFGKALQLTRHQRFV-HRLE--RRHKC--SICGKMFKKKSHVRNHLRTHTGERPFPC-------------- 528
Cdd:COG5048 289 PIKSKQCNISFSRSSPLTRHLRSVnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEkllnssskfsplln 368

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425222 529 -----------------------PDCSKPFNSPANLARHRLTHTGERP--YRCGDCGKAFTQSSTLRQHRLVHAQHFPYR 583
Cdd:COG5048 369 neppqslqqykdlkndkksetlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448


                ....*
gi 30425222 584 CQECG 588
Cdd:COG5048 449 CSILK 453
zf-H2C2_2 pfam13465
Zinc-finger double domain;
540-565 1.88e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.88e-04
                          10        20
                  ....*....|....*....|....*.
gi 30425222   540 NLARHRLTHTGERPYRCGDCGKAFTQ 565
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
784-808 2.62e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.62e-04
                          10        20
                  ....*....|....*....|....*
gi 30425222   784 HLKDHRRLHTGERPFACEVCGKAFA 808
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 522-605 3.43e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 3.43e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425222 522 GERPFPCP--DCSKPFNSPANLARHRLThtgerpyrcGDCGKAFTQSSTLRQHRLVHAQHFPYRCQECGVRFHRPYRLLM 599
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ....*.
gi 30425222 600 HRYHHT 605
Cdd:COG5189 417 HRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
812-837 6.65e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 6.65e-04
                          10        20
                  ....*....|....*....|....*.
gi 30425222   812 RLAEHRRIHTGERPYSCPDCGKSYRS 837
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 498-520 7.60e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 7.60e-04
                          10        20
                  ....*....|....*....|...
gi 30425222   498 HKCSICGKMFKKKSHVRNHLRTH 520
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 826-848 8.98e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 8.98e-04
                          10        20
                  ....*....|....*....|...
gi 30425222   826 YSCPDCGKSYRSFSNLWKHRKTH 848
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 770-792 1.16e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 1.16e-03
                          10        20
                  ....*....|....*....|...
gi 30425222   770 YPCPDCGKAFRQSTHLKDHRRLH 792
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
512-537 1.25e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.25e-03
                          10        20
                  ....*....|....*....|....*.
gi 30425222   512 HVRNHLRTHTGERPFPCPDCSKPFNS 537
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 554-576 2.89e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.89e-03
                          10        20
                  ....*....|....*....|...
gi 30425222   554 YRCGDCGKAFTQSSTLRQHRLVH 576
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
796-853 4.84e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 4.84e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425222 796 RPFACEVCGKAFAISMRLAEHRRIHTGERPYSCPD--CGKSYRSFSNLWKHRKTHQQQHQ 853
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPS 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH