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Conserved domains on  [gi|30425322|ref|NP_780748|]
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DDB1- and CUL4-associated factor 12-like protein 2 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 95-295 2.23e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 64.28  E-value: 2.23e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425322  95 ERQLTLGPLNKVFASQWLNARQVVCGTKCNTLFVVDVQTGRITRiplmrdrgpgqTRAQPTCGIHAIQLNPSKTLLATGG 174
Cdd:cd00200  44 LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR-----------TLTGHTSYVSSVAFSPDGRILSSSS 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425322 175 ENpNSLAVYQLPTldPVCLGDRQGHRDWIFAIAWMSD-TVAVSGSRDGTVALWRVDSDMFNGSIPWHNNSgipryshirp 253
Cdd:cd00200 113 RD-KTIKVWDVET--GKCLTTLRGHTDWVNSVAFSPDgTFVASSSQDGTIKLWDLRTGKCVATLTGHTGE---------- 179

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 30425322 254 rdmeaiprattnpgnrkVRALAFSGRNQELGAVSLDGYFHLW 295
Cdd:cd00200 180 -----------------VNSVAFSPDGEKLLSSSSDGTIKLW 204
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 95-295 2.23e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.28  E-value: 2.23e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425322  95 ERQLTLGPLNKVFASQWLNARQVVCGTKCNTLFVVDVQTGRITRiplmrdrgpgqTRAQPTCGIHAIQLNPSKTLLATGG 174
Cdd:cd00200  44 LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR-----------TLTGHTSYVSSVAFSPDGRILSSSS 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425322 175 ENpNSLAVYQLPTldPVCLGDRQGHRDWIFAIAWMSD-TVAVSGSRDGTVALWRVDSDMFNGSIPWHNNSgipryshirp 253
Cdd:cd00200 113 RD-KTIKVWDVET--GKCLTTLRGHTDWVNSVAFSPDgTFVASSSQDGTIKLWDLRTGKCVATLTGHTGE---------- 179

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 30425322 254 rdmeaiprattnpgnrkVRALAFSGRNQELGAVSLDGYFHLW 295
Cdd:cd00200 180 -----------------VNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
115-297 3.00e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.93  E-value: 3.00e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425322 115 RQVVCGTKCNTLFVVDVQTGRITRiplmrdrgpgqTRAQPTCGIHAIQLNPSKTLLATGGENpNSLAVYQLPTldPVCLG 194
Cdd:COG2319 259 RLLASGSADGTVRLWDLATGELLR-----------TLTGHSGGVNSVAFSPDGKLLASGSDD-GTVRLWDLAT--GKLLR 324

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425322 195 DRQGHRDWIFAIAWMSD-TVAVSGSRDGTVALWRVDSDMFNGSIPWHNNSgipryshirprdmeaiprattnpgnrkVRA 273
Cdd:COG2319 325 TLTGHTGAVRSVAFSPDgKTLASGSDDGTVRLWDLATGELLRTLTGHTGA---------------------------VTS 377

                       170       180
                ....*....|....*....|....
gi 30425322 274 LAFSGRNQELGAVSLDGYFHLWKA 297
Cdd:COG2319 378 VAFSPDGRTLASGSADGTVRLWDL 401
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 192-226 6.84e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 6.84e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 30425322    192 CLGDRQGHRDWIFAIAWMSD-TVAVSGSRDGTVALW 226
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDgKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
192-226 1.37e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.37e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 30425322   192 CLGDRQGHRDWIFAIAWMSD-TVAVSGSRDGTVALW 226
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDgKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 95-295 2.23e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.28  E-value: 2.23e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425322  95 ERQLTLGPLNKVFASQWLNARQVVCGTKCNTLFVVDVQTGRITRiplmrdrgpgqTRAQPTCGIHAIQLNPSKTLLATGG 174
Cdd:cd00200  44 LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR-----------TLTGHTSYVSSVAFSPDGRILSSSS 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425322 175 ENpNSLAVYQLPTldPVCLGDRQGHRDWIFAIAWMSD-TVAVSGSRDGTVALWRVDSDMFNGSIPWHNNSgipryshirp 253
Cdd:cd00200 113 RD-KTIKVWDVET--GKCLTTLRGHTDWVNSVAFSPDgTFVASSSQDGTIKLWDLRTGKCVATLTGHTGE---------- 179

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 30425322 254 rdmeaiprattnpgnrkVRALAFSGRNQELGAVSLDGYFHLW 295
Cdd:cd00200 180 -----------------VNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
115-297 3.00e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.93  E-value: 3.00e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425322 115 RQVVCGTKCNTLFVVDVQTGRITRiplmrdrgpgqTRAQPTCGIHAIQLNPSKTLLATGGENpNSLAVYQLPTldPVCLG 194
Cdd:COG2319 259 RLLASGSADGTVRLWDLATGELLR-----------TLTGHSGGVNSVAFSPDGKLLASGSDD-GTVRLWDLAT--GKLLR 324

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425322 195 DRQGHRDWIFAIAWMSD-TVAVSGSRDGTVALWRVDSDMFNGSIPWHNNSgipryshirprdmeaiprattnpgnrkVRA 273
Cdd:COG2319 325 TLTGHTGAVRSVAFSPDgKTLASGSDDGTVRLWDLATGELLRTLTGHTGA---------------------------VTS 377

                       170       180
                ....*....|....*....|....
gi 30425322 274 LAFSGRNQELGAVSLDGYFHLWKA 297
Cdd:COG2319 378 VAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 117-296 6.79e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.12  E-value: 6.79e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425322 117 VVCGTKCNTLFVVDVQTGRitriplmrdrgPGQTRAQPTCGIHAIQLNPSKTLLATGGENpNSLAVYQLPTLDpvCLGDR 196
Cdd:cd00200 150 VASSSQDGTIKLWDLRTGK-----------CVATLTGHTGEVNSVAFSPDGEKLLSSSSD-GTIKLWDLSTGK--CLGTL 215

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425322 197 QGHRDWIFAIAWMSDT-VAVSGSRDGTVALWRVDSDMFNGSIPWHNNSgipryshirprdmeaiprattnpgnrkVRALA 275
Cdd:cd00200 216 RGHENGVNSVAFSPDGyLLASGSEDGTIRVWDLRTGECVQTLSGHTNS---------------------------VTSLA 268

                       170       180
                ....*....|....*....|.
gi 30425322 276 FSGRNQELGAVSLDGYFHLWK 296
Cdd:cd00200 269 WSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
115-297 2.39e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.24  E-value: 2.39e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425322 115 RQVVCGTKCNTLFVVDVQTGRITRiplmrdrgpgqTRAQPTCGIHAIQLNPSKTLLATGGENpNSLAVYQLPTldPVCLG 194
Cdd:COG2319 175 KLLASGSDDGTVRLWDLATGKLLR-----------TLTGHTGAVRSVAFSPDGKLLASGSAD-GTVRLWDLAT--GKLLR 240

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425322 195 DRQGHRDWIFAIAWMSD-TVAVSGSRDGTVALWRVDSDMFNGSIPWHNNSgipryshirprdmeaiprattnpgnrkVRA 273
Cdd:COG2319 241 TLTGHSGSVRSVAFSPDgRLLASGSADGTVRLWDLATGELLRTLTGHSGG---------------------------VNS 293

                       170       180
                ....*....|....*....|....
gi 30425322 274 LAFSGRNQELGAVSLDGYFHLWKA 297
Cdd:COG2319 294 VAFSPDGKLLASGSDDGTVRLWDL 317
WD40 COG2319
WD40 repeat [General function prediction only];
26-295 3.53e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 3.53e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425322  26 PGRAAAAAGTGQADGPLLLAKRPRRPVARRSLVHYLKGRALGADGHPGVAGFEGDLRSYGVLRLPELLRERQLTLGPLNK 105
Cdd:COG2319   4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425322 106 VFASqwLNARQVVCGTKCNTLFVVDVQTGRITRIPLmrdrgpGQTRAqptcgIHAIQLNPSKTLLATGGENpNSLAVYQL 185
Cdd:COG2319  84 VAFS--PDGRLLASASADGTVRLWDLATGLLLRTLT------GHTGA-----VRSVAFSPDGKTLASGSAD-GTVRLWDL 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425322 186 PTldPVCLGDRQGHRDWIFAIAWMSD-TVAVSGSRDGTVALWRVDSDMFNGSIPWHNNSgipryshirprdmeaipratt 264
Cdd:COG2319 150 AT--GKLLRTLTGHSGAVTSVAFSPDgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA--------------------- 206

                       250       260       270
                ....*....|....*....|....*....|.
gi 30425322 265 npgnrkVRALAFSGRNQELGAVSLDGYFHLW 295
Cdd:COG2319 207 ------VRSVAFSPDGKLLASGSADGTVRLW 231
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 101-387 4.87e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.43  E-value: 4.87e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425322 101 GPLNKVFASQWLNARQVVC-GTKCNTLFVVDVQTGRITRiplmrdrgpgqTRAQPTCGIHAIQLNPSKTLLATGGENpNS 179
Cdd:cd00200   7 GHTGGVTCVAFSPDGKLLAtGSGDGTIKVWDLETGELLR-----------TLKGHTGPVRDVAASADGTYLASGSSD-KT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425322 180 LAVYQLPTldPVCLGDRQGHRDWIFAIAWMSD-TVAVSGSRDGTVALWRVDSDMFNGSIPWHNNSgipryshirprdmea 258
Cdd:cd00200  75 IRLWDLET--GECVRTLTGHTSYVSSVAFSPDgRILSSSSRDKTIKVWDVETGKCLTTLRGHTDW--------------- 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425322 259 iprattnpgnrkVRALAFSGRNQELGAVSLDGYFHLWKARSSlsrllslrlpYCRE-------NV-CLTYCDELSLYAVG 330
Cdd:cd00200 138 ------------VNSVAFSPDGTFVASSSQDGTIKLWDLRTG----------KCVAtltghtgEVnSVAFSPDGEKLLSS 195

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425322 331 SQSHVSFL-DPRQRQQnIKPLCSREGgtGVRSLSFYQH--IITVGTGHGSLLFYDIRAQK 387
Cdd:cd00200 196 SSDGTIKLwDLSTGKC-LGTLRGHEN--GVNSVAFSPDgyLLASGSEDGTIRVWDLRTGE 252
WD40 COG2319
WD40 repeat [General function prediction only];
124-230 8.60e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.23  E-value: 8.60e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425322 124 NTLFVVDVQTGRITRiplmrdrgpgqTRAQPTCGIHAIQLNPSKTLLATGGENpNSLAVYQLPTldPVCLGDRQGHRDWI 203
Cdd:COG2319 310 GTVRLWDLATGKLLR-----------TLTGHTGAVRSVAFSPDGKTLASGSDD-GTVRLWDLAT--GELLRTLTGHTGAV 375

                        90       100
                ....*....|....*....|....*...
gi 30425322 204 FAIAWMSD-TVAVSGSRDGTVALWRVDS 230
Cdd:COG2319 376 TSVAFSPDgRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 192-226 6.84e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 6.84e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 30425322    192 CLGDRQGHRDWIFAIAWMSD-TVAVSGSRDGTVALW 226
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDgKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
192-226 1.37e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.37e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 30425322   192 CLGDRQGHRDWIFAIAWMSD-TVAVSGSRDGTVALW 226
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDgKLLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 197-231 2.30e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.01  E-value: 2.30e-03
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 30425322 197 QGHRDWIFAIAWMSDT-VAVSGSRDGTVALWRVDSD 231
Cdd:cd00200   6 KGHTGGVTCVAFSPDGkLLATGSGDGTIKVWDLETG 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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