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Conserved domains on  [gi|30520017|ref|NP_848771|]
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phosphoinositide-interacting protein [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PIRT super family cl20968
Phosphoinositide-interacting protein family; The function of this family, PIRT, is not known, ...
 5-135 5.18e-57

Phosphoinositide-interacting protein family; The function of this family, PIRT, is not known, however it is predicted to be a multi-pass membrane protein. This family of proteins is thought to have a role in positively regulating TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). This family of proteins is found in eukaryotes. Proteins in this family are located in the cell membrane. Proteins in this family are approximately 140 amino acids in length.


The actual alignment was detected with superfamily member pfam15099:

Pssm-ID: 434456  Cd Length: 128  Bit Score: 173.26  E-value: 5.18e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30520017     5 PKALEVDERSPESKDLLPSQTASSLCISSRSESVWTTTPKSNWEIYHKPIIIMSVGAAILLFGVAITCVAyILEEKHKvv 84
Cdd:pfam15099   1 PNSPEDSEKSPESKELLTSQTASTLCISSRSESVWTTPPRSKWDIYHKPVIVLSVGAAVFLFGVVITSLS-CFKNKNK-- 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 30520017    85 QVLRMIGPAFLSLGLMMLVCGLVWVPIIKKKQKQRQKSNFFQSLKFFLLNR 135
Cdd:pfam15099  78 EVYKMCGPAFLSLGLMLLVCGLVWIPIIRKKQKQRQKSQFLQSLKSFFFNR 128
 
Name Accession Description Interval E-value
PIRT pfam15099
Phosphoinositide-interacting protein family; The function of this family, PIRT, is not known, ...
 5-135 5.18e-57

Phosphoinositide-interacting protein family; The function of this family, PIRT, is not known, however it is predicted to be a multi-pass membrane protein. This family of proteins is thought to have a role in positively regulating TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). This family of proteins is found in eukaryotes. Proteins in this family are located in the cell membrane. Proteins in this family are approximately 140 amino acids in length.


Pssm-ID: 434456  Cd Length: 128  Bit Score: 173.26  E-value: 5.18e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30520017     5 PKALEVDERSPESKDLLPSQTASSLCISSRSESVWTTTPKSNWEIYHKPIIIMSVGAAILLFGVAITCVAyILEEKHKvv 84
Cdd:pfam15099   1 PNSPEDSEKSPESKELLTSQTASTLCISSRSESVWTTPPRSKWDIYHKPVIVLSVGAAVFLFGVVITSLS-CFKNKNK-- 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 30520017    85 QVLRMIGPAFLSLGLMMLVCGLVWVPIIKKKQKQRQKSNFFQSLKFFLLNR 135
Cdd:pfam15099  78 EVYKMCGPAFLSLGLMLLVCGLVWIPIIRKKQKQRQKSQFLQSLKSFFFNR 128
 
Name Accession Description Interval E-value
PIRT pfam15099
Phosphoinositide-interacting protein family; The function of this family, PIRT, is not known, ...
 5-135 5.18e-57

Phosphoinositide-interacting protein family; The function of this family, PIRT, is not known, however it is predicted to be a multi-pass membrane protein. This family of proteins is thought to have a role in positively regulating TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). This family of proteins is found in eukaryotes. Proteins in this family are located in the cell membrane. Proteins in this family are approximately 140 amino acids in length.


Pssm-ID: 434456  Cd Length: 128  Bit Score: 173.26  E-value: 5.18e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30520017     5 PKALEVDERSPESKDLLPSQTASSLCISSRSESVWTTTPKSNWEIYHKPIIIMSVGAAILLFGVAITCVAyILEEKHKvv 84
Cdd:pfam15099   1 PNSPEDSEKSPESKELLTSQTASTLCISSRSESVWTTPPRSKWDIYHKPVIVLSVGAAVFLFGVVITSLS-CFKNKNK-- 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 30520017    85 QVLRMIGPAFLSLGLMMLVCGLVWVPIIKKKQKQRQKSNFFQSLKFFLLNR 135
Cdd:pfam15099  78 EVYKMCGPAFLSLGLMLLVCGLVWIPIIRKKQKQRQKSQFLQSLKSFFFNR 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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