NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|31982342|ref|NP_848855|]
View 

SLIT and NTRK-like protein 4 precursor [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
59-213 6.00e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 6.00e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342  59 SNFYHLNFQNNFLNILyPNTFVNFSHAVSLHLGNNKLQNIeGGAFLGLSALKQLHLNNNELKILrADTFLGIENLEYLQA 138
Cdd:COG4886 113 TNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDL 189

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31982342 139 DYNLIKYIErGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIgrvVELQLEDN 213
Cdd:COG4886 190 SNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNL---EELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
358-531 8.00e-13

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 8.00e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342 358 SVNCQEKNIQSMSELTPKPLNAKKLHVNGNNIKDVDiSDFTEFEGLDLLHLGSNQITLIKGEVFhNLTNLRRLYLNGNQI 437
Cdd:COG4886 117 SLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELG-NLTNLKELDLSNNQI 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342 438 ERLyPEIFSGLHNLQYLYLEYNLIKEIlagtfdsmpnlqllylnnnllkslPVYIFSGAPLARLNLRNNKFMYLPvsgVL 517
Cdd:COG4886 195 TDL-PEPLGNLTNLEELDLSGNQLTDL------------------------PEPLANLTNLETLDLSNNQLTDLP---EL 246

                       170
                ....*....|....
gi 31982342 518 DQLQSLTQIDLEGN 531
Cdd:COG4886 247 GNLTNLEELDLSNN 260
LRRCT smart00082
Leucine rich repeat C-terminal domain;
213-253 8.24e-07

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 46.65  E-value: 8.24e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 31982342    213 NPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLL 253
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLL 41
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 502-563 5.15e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 43.92  E-value: 5.15e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31982342    502 NLRNNKFMYLPvSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWLEKLNDGIVVKELK-CETP 563
Cdd:TIGR00864    1 DISNNKISTIE-EGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAAlCAGP 62
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
59-213 6.00e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 6.00e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342  59 SNFYHLNFQNNFLNILyPNTFVNFSHAVSLHLGNNKLQNIeGGAFLGLSALKQLHLNNNELKILrADTFLGIENLEYLQA 138
Cdd:COG4886 113 TNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDL 189

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31982342 139 DYNLIKYIErGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIgrvVELQLEDN 213
Cdd:COG4886 190 SNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNL---EELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
358-531 8.00e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 8.00e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342 358 SVNCQEKNIQSMSELTPKPLNAKKLHVNGNNIKDVDiSDFTEFEGLDLLHLGSNQITLIKGEVFhNLTNLRRLYLNGNQI 437
Cdd:COG4886 117 SLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELG-NLTNLKELDLSNNQI 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342 438 ERLyPEIFSGLHNLQYLYLEYNLIKEIlagtfdsmpnlqllylnnnllkslPVYIFSGAPLARLNLRNNKFMYLPvsgVL 517
Cdd:COG4886 195 TDL-PEPLGNLTNLEELDLSGNQLTDL------------------------PEPLANLTNLETLDLSNNQLTDLP---EL 246

                       170
                ....*....|....
gi 31982342 518 DQLQSLTQIDLEGN 531
Cdd:COG4886 247 GNLTNLEELDLSNN 260
LRR_8 pfam13855
Leucine rich repeat;
402-461 1.03e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.31  E-value: 1.03e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342   402 GLDLLHLGSNQITLIKGEVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLI 461
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
83-143 7.25e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 7.25e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31982342    83 SHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLI 143
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 382-464 2.28e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.42  E-value: 2.28e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342 382 LHVNGNNIKDvdISDFTEFEGLDLLHLGSNQITLIKGevFHNLTNLRRLYLNGNQIERLypEIFSGLHNLQYLYLEYNLI 461
Cdd:cd21340   7 LYLNDKNITK--IDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRI 80


                ...
gi 31982342 462 KEI 464
Cdd:cd21340  81 SVV 83
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 63-233 8.14e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 8.14e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342  63 HLNFQNNflNILYPNTFVNFSHAVSLHLGNNKLQNIEGgaFLGLSALKQLHLNNNelKILRADTFLGIENLEYLQADYNL 142
Cdd:cd21340   6 HLYLNDK--NITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNN--QIEKIENLENLVNLKKLYLGGNR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342 143 IKYIErgAFNKLHKLKVL-ILNDNL-----ISFLPDNIFRFA-SLTHLDIRGNRIQKLPYIGVLEHIgrvVELQLEDnpw 215
Cdd:cd21340  80 ISVVE--GLENLTNLEELhIENQRLppgekLTFDPRSLAALSnSLRVLNISGNNIDSLEPLAPLRNL---EQLDASN--- 151

                       170
                ....*....|....*...
gi 31982342 216 NCSCDLLPLKAWLENMPY 233
Cdd:cd21340 152 NQISDLEELLDLLSSWPS 169
LRRCT smart00082
Leucine rich repeat C-terminal domain;
213-253 8.24e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 46.65  E-value: 8.24e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 31982342    213 NPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLL 253
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLL 41
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 502-563 5.15e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 43.92  E-value: 5.15e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31982342    502 NLRNNKFMYLPvSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWLEKLNDGIVVKELK-CETP 563
Cdd:TIGR00864    1 DISNNKISTIE-EGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAAlCAGP 62
LRRCT smart00082
Leucine rich repeat C-terminal domain;
531-563 3.09e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 36.25  E-value: 3.09e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 31982342    531 NPWDCTCDLVALKLWLEKLNDGIVVKELKCETP 563
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASP 33
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
59-213 6.00e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 6.00e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342  59 SNFYHLNFQNNFLNILyPNTFVNFSHAVSLHLGNNKLQNIeGGAFLGLSALKQLHLNNNELKILrADTFLGIENLEYLQA 138
Cdd:COG4886 113 TNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDL 189

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31982342 139 DYNLIKYIErGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIgrvVELQLEDN 213
Cdd:COG4886 190 SNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNL---EELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
63-214 1.22e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.81  E-value: 1.22e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342  63 HLNFQNNFLNILyPNTFVNFSHAVSLHLGNNKLQNIeGGAFLGLSALKQLHLNNNELKILrADTFLGIENLEYLQADYNL 142
Cdd:COG4886 140 ELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQ 216

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31982342 143 IKYIERgAFNKLHKLKVLILNDNLISFLPdNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGrvvELQLEDNP 214
Cdd:COG4886 217 LTDLPE-PLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLK---TLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
358-531 8.00e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 8.00e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342 358 SVNCQEKNIQSMSELTPKPLNAKKLHVNGNNIKDVDiSDFTEFEGLDLLHLGSNQITLIKGEVFhNLTNLRRLYLNGNQI 437
Cdd:COG4886 117 SLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELG-NLTNLKELDLSNNQI 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342 438 ERLyPEIFSGLHNLQYLYLEYNLIKEIlagtfdsmpnlqllylnnnllkslPVYIFSGAPLARLNLRNNKFMYLPvsgVL 517
Cdd:COG4886 195 TDL-PEPLGNLTNLEELDLSGNQLTDL------------------------PEPLANLTNLETLDLSNNQLTDLP---EL 246

                       170
                ....*....|....
gi 31982342 518 DQLQSLTQIDLEGN 531
Cdd:COG4886 247 GNLTNLEELDLSNN 260
LRR_8 pfam13855
Leucine rich repeat;
402-461 1.03e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.31  E-value: 1.03e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342   402 GLDLLHLGSNQITLIKGEVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLI 461
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
380-532 7.18e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 7.18e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342 380 KKLHVNGNNIKDVDISdFTEFEGLDLLHLGSNQITLIkGEVFHNLTNLRRLYLNGNQIERLyPEIFSGLHNLQYLYLEYN 459
Cdd:COG4886 162 KSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNN 238

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31982342 460 LIKEIlaGTFDSMPNlqllylnnnllkslpvyifsgapLARLNLRNNKFMYLPVSGvldQLQSLTQIDLEGNP 532
Cdd:COG4886 239 QLTDL--PELGNLTN-----------------------LEELDLSNNQLTDLPPLA---NLTNLKTLDLSNNQ 283
LRR_8 pfam13855
Leucine rich repeat;
83-143 7.25e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 7.25e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31982342    83 SHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLI 143
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 382-464 2.28e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.42  E-value: 2.28e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342 382 LHVNGNNIKDvdISDFTEFEGLDLLHLGSNQITLIKGevFHNLTNLRRLYLNGNQIERLypEIFSGLHNLQYLYLEYNLI 461
Cdd:cd21340   7 LYLNDKNITK--IDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRI 80


                ...
gi 31982342 462 KEI 464
Cdd:cd21340  81 SVV 83
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 359-550 5.17e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.18  E-value: 5.17e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342 359 VNCQEKNIQSMSELTPKPlNAKKLHVNGNNIKDvdISDFTEFEGLDLLHLGSNQITLIKGevFHNLTNLRRLYLNGNQIE 438
Cdd:cd21340   7 LYLNDKNITKIDNLSLCK-NLKVLYLYDNKITK--IENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342 439 RLypEIFSGLHNLQYLYLEYNLIKEILAGTFDSmpnlqllylnnnllkslpvyiFSGAPLAR----LNLRNNKFMYLpvs 514
Cdd:cd21340  82 VV--EGLENLTNLEELHIENQRLPPGEKLTFDP---------------------RSLAALSNslrvLNISGNNIDSL--- 135

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 31982342 515 GVLDQLQSLTQIDLEGNP---WDCTCDLVALKLWLEKLN 550
Cdd:cd21340 136 EPLAPLRNLEQLDASNNQisdLEELLDLLSSWPSLRELD 174
LRR_8 pfam13855
Leucine rich repeat;
378-437 2.41e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 2.41e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342   378 NAKKLHVNGNNIKDVDISDFTEFEGLDLLHLGSNQITLIKGEVFHNLTNLRRLYLNGNQI 437
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
425-473 2.04e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 2.04e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 31982342   425 TNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEILAGTFDSMP 473
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP 49
LRR_8 pfam13855
Leucine rich repeat;
132-190 2.82e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 2.82e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342   132 NLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFR-FASLTHLDIRGNRI 190
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
109-167 3.36e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 3.36e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 31982342   109 LKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLI 167
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 63-233 8.14e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 8.14e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342  63 HLNFQNNflNILYPNTFVNFSHAVSLHLGNNKLQNIEGgaFLGLSALKQLHLNNNelKILRADTFLGIENLEYLQADYNL 142
Cdd:cd21340   6 HLYLNDK--NITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNN--QIEKIENLENLVNLKKLYLGGNR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342 143 IKYIErgAFNKLHKLKVL-ILNDNL-----ISFLPDNIFRFA-SLTHLDIRGNRIQKLPYIGVLEHIgrvVELQLEDnpw 215
Cdd:cd21340  80 ISVVE--GLENLTNLEELhIENQRLppgekLTFDPRSLAALSnSLRVLNISGNNIDSLEPLAPLRNL---EQLDASN--- 151

                       170
                ....*....|....*...
gi 31982342 216 NCSCDLLPLKAWLENMPY 233
Cdd:cd21340 152 NQISDLEELLDLLSSWPS 169
LRR_8 pfam13855
Leucine rich repeat;
59-119 6.05e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 6.05e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31982342    59 SNFYHLNFQNNFLNILYPNTFVNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNEL 119
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
213-253 8.24e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 46.65  E-value: 8.24e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 31982342    213 NPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLL 253
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLL 41
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 63-194 1.22e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.17  E-value: 1.22e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342  63 HLNFQNNFLNILypntfVNFSHAVSL---HLGNNKLQNIEGgaFLGLSALKQLHLNNNELK-----ILRADTFLGI-ENL 133
Cdd:cd21340  50 HLYLQNNQIEKI-----ENLENLVNLkklYLGGNRISVVEG--LENLTNLEELHIENQRLPpgeklTFDPRSLAALsNSL 122

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31982342 134 EYLQADYNLIKYIErgAFNKLHKLKVLILNDNLISFLPD---NIFRFASLTHLDIRGNRIQKLP 194
Cdd:cd21340 123 RVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEElldLLSSWPSLRELDLTGNPVCKKP 184
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
377-531 1.80e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.09  E-value: 1.80e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342 377 LNAKKLHVNGNNIKDVDISDFTEFEGLDLLHLGSNqitlikgEVFHNLTNLRRLYLNGNQIERLyPEIFSGLHNLQYLYL 456
Cdd:COG4886  72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDL 143

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31982342 457 EYNLIKEILAgTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSgvLDQLQSLTQIDLEGN 531
Cdd:COG4886 144 SNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEP--LGNLTNLEELDLSGN 215
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
42-194 5.41e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.47  E-value: 5.41e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342  42 NCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFVNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKI 121
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31982342 122 LRADTFLGIENLEYLQADYNLIKYiERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLP 194
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTELDLS-GNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP 152
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 502-563 5.15e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 43.92  E-value: 5.15e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31982342    502 NLRNNKFMYLPvSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWLEKLNDGIVVKELK-CETP 563
Cdd:TIGR00864    1 DISNNKISTIE-EGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAAlCAGP 62
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
363-532 9.60e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 9.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342 363 EKNIQSMSELTPKPLNAKKLHVNGNNIKDVDISDFTEFEGLDLLHLGSNQITLIKGEVFHNLTNLRRL------------ 430
Cdd:COG4886  34 LLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELdlsgneelsnlt 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342 431 -----YLNGNQIERLyPEIFSGLHNLQYLYLEYNLIKEIlagtfdsmpnlqllylnnnllkslPVYIFSGAPLARLNLRN 505
Cdd:COG4886 114 nleslDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL------------------------PEPLGNLTNLKSLDLSN 168

                       170       180
                ....*....|....*....|....*..
gi 31982342 506 NKFMYLPVSgvLDQLQSLTQIDLEGNP 532
Cdd:COG4886 169 NQLTDLPEE--LGNLTNLKELDLSNNQ 193
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 93-188 9.92e-04

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.84  E-value: 9.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342    93 NKLQNIEGGAFLGLSALKQLHLNNNeLKILRADTFLGIeNLEYLQADYNlIKYIERGAFNKLHKLKVLILNDNLISFlPD 172
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNC-SLTSITIPSS-LTSIGEYAFSNCSNLKSITLPSNLTSI-GS 95

                          90
                  ....*....|....*.
gi 31982342   173 NIFRFASLTHLDIRGN 188
Cdd:pfam13306  96 YAFSNCSLKSITIPSS 111
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 425-459 1.50e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.22  E-value: 1.50e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 31982342   425 TNLRRLYLNGNQIERLypEIFSGLHNLQYLYLEYN 459
Cdd:pfam12799   1 PNLEVLDLSNNQITDI--PPLAKLPNLETLDLSGN 33
LRR_8 pfam13855
Leucine rich repeat;
156-214 1.64e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.64e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342   156 KLKVLILNDNLISFLPDNIFR-FASLTHLDIRGNRIQKLPYiGVLEHIGRVVELQLEDNP 214
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNR 60
LRRCT smart00082
Leucine rich repeat C-terminal domain;
531-563 3.09e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 36.25  E-value: 3.09e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 31982342    531 NPWDCTCDLVALKLWLEKLNDGIVVKELKCETP 563
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASP 33
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
71-470 5.75e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.92  E-value: 5.75e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342  71 LNILYPNTFVNFSHAVSLHLGNNKLQNIeGGAFLGLSALKQLHLNNNELKILRADtFLGIENLEYLQADYNLIKYIERgA 150
Cdd:COG4886 101 LDLSGNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPE-E 177

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342 151 FNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPyigvlehigrvvelqlednpwncscdllplkAWLEN 230
Cdd:COG4886 178 LGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLP-------------------------------EPLAN 226

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342 231 MpyniyigeaicetpsdlygrllketnkqelcpmgtgsdfdvrilppsqqengfttpnghttqTTLHRLvtkppkttnps 310
Cdd:COG4886 227 L--------------------------------------------------------------TNLETL----------- 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342 311 kisgivagkalsnrNLSqivsyqtrvppltpcpvpcfckthpsdlglsvNCQEKNIQSMSELTpkplNAKKLHVNGNNIK 390
Cdd:COG4886 234 --------------DLS--------------------------------NNQLTDLPELGNLT----NLEELDLSNNQLT 263

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982342 391 DvdISDFTEFEGLDLLHLGSNQITLIKGEVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEILAGTFD 470
Cdd:COG4886 264 D--LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLA 341
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH