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Conserved domains on  [gi|31742516|ref|NP_852090|]
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frataxin, mitochondrial isoform 2 preproprotein [Homo sapiens]

Protein Classification

frataxin family protein( domain architecture ID 2077)

frataxin family protein promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways; similar to Trachipleistophora hominis frataxin

CATH:  3.30.920.10
Gene Ontology:  GO:0008199|GO:0008198|GO:0016226
SCOP:  4001566
TCDB:  9.B.21

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Frataxin super family cl00238
Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), ...
 94-162 7.09e-33

Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in the mitochondrial matrix suggesting that frataxin is involved in mitochondrial iron homeostasis and possibly in iron transport; the domain has an alpha-beta fold consisting of two helices flanking an antiparallel beta sheet.


The actual alignment was detected with superfamily member TIGR03422:

Pssm-ID: 469678  Cd Length: 97  Bit Score: 113.48  E-value: 7.09e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31742516    94 TYERLAEETLDSLAEFFEDLADKPYTFeDYDVSFGSGVLTVKLGGdLGTYVINKQTPNKQIWLSS----PSRY 162
Cdd:TIGR03422   1 EYHKVADEYLDHLLDKLEELGESRPDL-DFDVEYSSGVLTLELPS-VGTYVINKQPPNKQIWLSSpvsgPKRY 71
 
Name Accession Description Interval E-value
mito_frataxin TIGR03422
frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease ...
 94-162 7.09e-33

frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease Friedreich's ataxia. Its orthologs are widely distributed in the bacteria, associated with the ISC system for iron-sulfur cluster assembly, and designated CyaY. This exception-type model allows those examples of frataxin per se that score above the trusted cutoff to the CyaY equivalog-type model (TIGR03421) to be named appropriately.


Pssm-ID: 132463  Cd Length: 97  Bit Score: 113.48  E-value: 7.09e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31742516    94 TYERLAEETLDSLAEFFEDLADKPYTFeDYDVSFGSGVLTVKLGGdLGTYVINKQTPNKQIWLSS----PSRY 162
Cdd:TIGR03422   1 EYHKVADEYLDHLLDKLEELGESRPDL-DFDVEYSSGVLTLELPS-VGTYVINKQPPNKQIWLSSpvsgPKRY 71
Frataxin_Cyay pfam01491
Frataxin-like domain; This family contains proteins that have a domain related to the globular ...
 90-159 9.05e-31

Frataxin-like domain; This family contains proteins that have a domain related to the globular C-terminus of Frataxin the protein that is mutated in Friedreich's ataxia. This domain is found in a family of bacterial proteins. The function of this domain is currently unknown. It has been suggested that this family is involved in iron transport.


Pssm-ID: 460230  Cd Length: 106  Bit Score: 108.38  E-value: 9.05e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31742516    90 LDETTYERLAEETLDSLAEFFEDLADKPytfEDYDVSFGSGVLTVKLGgDLGTYVINKQTPNKQIWLSSP 159
Cdd:pfam01491   1 MTDSEFHRLADATLESLEDSLEELLDEG---SDADVEYSGGVLTLEFD-NGGTYVINKQPPNRQIWLSSP 66
Frataxin cd00503
Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), ...
 90-160 1.85e-27

Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in the mitochondrial matrix suggesting that frataxin is involved in mitochondrial iron homeostasis and possibly in iron transport; the domain has an alpha-beta fold consisting of two helices flanking an antiparallel beta sheet.


Pssm-ID: 238280  Cd Length: 105  Bit Score: 99.65  E-value: 1.85e-27
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31742516  90 LDETTYERLAEETLDSLAEFFEDLADKpytfEDYDVSFGSGVLTVKLGgDLGTYVINKQTPNKQIWLSSPS 160
Cdd:cd00503   1 MNESEFHRLADDLLLKIEDTLEEQDDD----ADIDVETQGGVLTLTFG-NGSTIVINRQEPLRQIWLASKV 66
CyaY COG1965
Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; ...
 90-160 5.20e-12

Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; Fe-S cluster assembly protein CyaY, frataxin homolog is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441568  Cd Length: 106  Bit Score: 59.81  E-value: 5.20e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31742516  90 LDETTYERLAEETLDSLAEFFEDLADkpytfEDYDVSFGSGVLTVKLGGDlGTYVINKQTPNKQIWLSSPS 160
Cdd:COG1965   1 MTESEFHQLADALLEAIEEALDRDDD-----ADIDCERSGGVLTLEFDNG-SKIIINRQEPLRQIWLAAKS 65
cyaY PRK00446
frataxin-like protein; Provisional
 90-160 4.98e-08

frataxin-like protein; Provisional


Pssm-ID: 234765  Cd Length: 105  Bit Score: 49.11  E-value: 4.98e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31742516   90 LDETTYERLAEETLDSLAEFFEDLADKpytfeDYDVSFGSGVLTVKLGGdlGT-YVINKQTPNKQIWLSSPS 160
Cdd:PRK00446   1 MNDSEFHQLADALWQAIEEQLDDDGDA-----DIDCERNGGVLTLTFEN--GSkIIINRQEPLHELWLAAKS 65
 
Name Accession Description Interval E-value
mito_frataxin TIGR03422
frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease ...
 94-162 7.09e-33

frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease Friedreich's ataxia. Its orthologs are widely distributed in the bacteria, associated with the ISC system for iron-sulfur cluster assembly, and designated CyaY. This exception-type model allows those examples of frataxin per se that score above the trusted cutoff to the CyaY equivalog-type model (TIGR03421) to be named appropriately.


Pssm-ID: 132463  Cd Length: 97  Bit Score: 113.48  E-value: 7.09e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31742516    94 TYERLAEETLDSLAEFFEDLADKPYTFeDYDVSFGSGVLTVKLGGdLGTYVINKQTPNKQIWLSS----PSRY 162
Cdd:TIGR03422   1 EYHKVADEYLDHLLDKLEELGESRPDL-DFDVEYSSGVLTLELPS-VGTYVINKQPPNKQIWLSSpvsgPKRY 71
Frataxin_Cyay pfam01491
Frataxin-like domain; This family contains proteins that have a domain related to the globular ...
 90-159 9.05e-31

Frataxin-like domain; This family contains proteins that have a domain related to the globular C-terminus of Frataxin the protein that is mutated in Friedreich's ataxia. This domain is found in a family of bacterial proteins. The function of this domain is currently unknown. It has been suggested that this family is involved in iron transport.


Pssm-ID: 460230  Cd Length: 106  Bit Score: 108.38  E-value: 9.05e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31742516    90 LDETTYERLAEETLDSLAEFFEDLADKPytfEDYDVSFGSGVLTVKLGgDLGTYVINKQTPNKQIWLSSP 159
Cdd:pfam01491   1 MTDSEFHRLADATLESLEDSLEELLDEG---SDADVEYSGGVLTLEFD-NGGTYVINKQPPNRQIWLSSP 66
Frataxin cd00503
Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), ...
 90-160 1.85e-27

Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in the mitochondrial matrix suggesting that frataxin is involved in mitochondrial iron homeostasis and possibly in iron transport; the domain has an alpha-beta fold consisting of two helices flanking an antiparallel beta sheet.


Pssm-ID: 238280  Cd Length: 105  Bit Score: 99.65  E-value: 1.85e-27
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31742516  90 LDETTYERLAEETLDSLAEFFEDLADKpytfEDYDVSFGSGVLTVKLGgDLGTYVINKQTPNKQIWLSSPS 160
Cdd:cd00503   1 MNESEFHRLADDLLLKIEDTLEEQDDD----ADIDVETQGGVLTLTFG-NGSTIVINRQEPLRQIWLASKV 66
FeS_CyaY TIGR03421
iron donor protein CyaY; Members of this protein family are the iron-sulfur cluster (FeS) ...
 91-160 1.37e-18

iron donor protein CyaY; Members of this protein family are the iron-sulfur cluster (FeS) metabolism protein CyaY, a homolog of eukaryotic frataxin. ISC is one of several bacterial systems for FeS assembly; we find by Partial Phylogenetic Profiling vs. the ISC system that CyaY most like work with the ISC system for FeS cluster biosynthesis. A study of of cyaY mutants in Salmonella enterica bears this out. Although the trusted cutoff is set low enough to include eukaryotic frataxin sequences, a narrower, exception-type model (TIGR03421) identifies identifies members of that specific set. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274572  Cd Length: 102  Bit Score: 76.86  E-value: 1.37e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31742516    91 DETTYERLAEETLDSLAEFFEDlADKpytfeDYDVSFGSGVLTVKLGgDLGTYVINKQTPNKQIWLSSPS 160
Cdd:TIGR03421   1 NESEFHQLAEALLDAIEEAIDD-GDA-----DIDCERQGGVLTLTFE-NGSQIIINKQEPLHQIWLAAKS 63
CyaY COG1965
Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; ...
 90-160 5.20e-12

Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; Fe-S cluster assembly protein CyaY, frataxin homolog is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441568  Cd Length: 106  Bit Score: 59.81  E-value: 5.20e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31742516  90 LDETTYERLAEETLDSLAEFFEDLADkpytfEDYDVSFGSGVLTVKLGGDlGTYVINKQTPNKQIWLSSPS 160
Cdd:COG1965   1 MTESEFHQLADALLEAIEEALDRDDD-----ADIDCERSGGVLTLEFDNG-SKIIINRQEPLRQIWLAAKS 65
cyaY PRK00446
frataxin-like protein; Provisional
 90-160 4.98e-08

frataxin-like protein; Provisional


Pssm-ID: 234765  Cd Length: 105  Bit Score: 49.11  E-value: 4.98e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31742516   90 LDETTYERLAEETLDSLAEFFEDLADKpytfeDYDVSFGSGVLTVKLGGdlGT-YVINKQTPNKQIWLSSPS 160
Cdd:PRK00446   1 MNDSEFHQLADALWQAIEEQLDDDGDA-----DIDCERNGGVLTLTFEN--GSkIIINRQEPLHELWLAAKS 65
cyaY PRK01379
iron donor protein CyaY;
90-159 7.15e-07

iron donor protein CyaY;


Pssm-ID: 134546  Cd Length: 103  Bit Score: 46.08  E-value: 7.15e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31742516   90 LDETTYERLAEETLDSLAEFFEDlADKPYTFedyDVSFGSGVLTvkLGGDLGTYVINKQTPNKQIWLSSP 159
Cdd:PRK01379   1 MNNSEFSKIAETTIAYIADKIEE-QDKEASI---DVDLQGDILN--LDTDKGIYVINKQSAAKEIWLSSP 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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