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Conserved domains on  [gi|256773243|ref|NP_898961|]
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methylcytosine dioxygenase TET3 isoform 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TET3 cd18897
oxygenase domain of ten-eleven translocation (TET)3 methylcytosine dioxygenase and similar ...
 701-1025 0e+00

oxygenase domain of ten-eleven translocation (TET)3 methylcytosine dioxygenase and similar proteins; TET3 is involved in DNA demethylation through iteratively oxidizing 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). TET proteins contain a C-terminal catalytic domain which consists of a cysteine-rich region and a double-stranded beta-helix (DSBH) fold. TET3 serves as a tumor suppressor; it acts as a suppressor of ovarian cancer by demethylating the miR-30d precursor gene promoter to block TGF-beta1 induced epithelial-mesenchymal transition (EMT). TET3 (and TET2) promoters are silenced in melanoma cells by mechanisms triggered by TGF-beta and mediated by DNA methyltransferase 3 alpha (DNMT3A), which play a functional role in the EMT process and metastasis. In addition, TET3 (and TET2) may be guardians of regulatory T cell stability and immune homeostasis. TET3 has been shown to prevent terminal differentiation of adult neural stem cells by a mechanism involving direct binding and repression of TET3 to the imprinted gene Snrpn. TET3 has also been shown to mediate the activation of hepatic stellate cells via modulation of the long non-coding RNA HIF1A-AS1 expression. TET1 belongs to the TET/JBP family of dioxygenases that require Fe2+ and alpha-ketoglutarate (also known as 2-oxoglutarate) for activity.


:

Pssm-ID: 380676  Cd Length: 452  Bit Score: 726.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  701 CDCVEQIVEKDEGPYYTHLGSGPTVASIRELMEDRYGEKGKAIRIEKVIYTGKEGKSSRGCPIAKWVIRRHTLEEKLLCL 780
Cdd:cd18897     1 CDCVEQILEKDEGPYYTHLGSGPTVASIRELMEERYGEKGKAIRIEKVIYTGKEGKSSRGCPIAKWVIRRSSEEEKLLCL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  781 VRHRAGHHCQNAVIVILILAWEGIPRSLGDTLYQELTDTLRKYGNPTSRRCGLNDDRTCACQGKDPNTCGASFSFGCSWS 860
Cdd:cd18897    81 VRHRAGHHCQNAVIVILILAWEGIPRALGDKLYQELTETLTKYGNPTSRRCGLNDDRTCACQGKDPNTCGASFSFGCSWS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  861 MYFNGCKYARSKTPRKFRLTGDNPKEEEVLRNSFQDLATEVAPLYKRLAPQAYQNQVTNEDVAIDCRLGLKEGRPFSGVT 940
Cdd:cd18897   161 MYFNGCKYARSKTPRKFRLIGDNPKEEENLRDNFQDLATEVAPLYKRLAPQAYQNQVTNEDIAIDCRLGLKEGRPFSGVT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  941 ACMDFCAHAHKDQHNLYNGCTVVCTLTKEDNRCVGQIPEDEQLHVLPLYKMASTDEFGSEENQNAKVSSGAIQVLTAFPR 1020
Cdd:cd18897   241 ACMDFCAHAHKDQHNLYNGCTVVCTLTKEDNRTVGKIPEDEQLHVLPLYKMSTTDEFGSEENQNEKIGSGAIQVLTSFPR 320


                  ....*
gi 256773243 1021 EVRRL 1025
Cdd:cd18897   321 EVREV 325
Tet_JBP super family cl40427
oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and ...
 1477-1639 2.24e-81

oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins; TET proteins are involved in DNA demethylation through iteratively oxidizing 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). TET proteins contain a C-terminal catalytic domain which consists of a cysteine-rich region and a double-stranded beta-helix (DSBH) fold. Alterations in TET protein function have been linked to cancer, and TETs influence many cell differentiation processes. J binding protein (JBP) 1 and JBP2 are thymidine hydroxylases that catalyze the first step of base J biosynthesis: the hydroxylation of thymine in DNA to form 5-hydroxymethyluracil (hmU). Base J (beta-d-glucopyranosyloxymethyluracil) is a hyper-modified DNA base found in the DNA of kinetoplastids (Trypanosoma brucei, Trypanosoma cruzi, and Leishmania). JBP1 and JBP2 each contain a J-DNA binding domain and a thymidine hydroxylase domain. Members of this TET/JBP family of dioxygenases require Fe2+ and alpha-ketoglutarate (also known as 2-oxoglutarate) for activity.


The actual alignment was detected with superfamily member cd18897:

Pssm-ID: 394797  Cd Length: 452  Bit Score: 276.10  E-value: 2.24e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243 1477 DPFSLEEGTAEEPPSkGVVKEEKSGPtveEDEEELWSDSEHNFLDENIGGVAVAPAHCSILIECARRELHATTPLKKPNR 1556
Cdd:cd18897   295 DEFGSEENQNEKIGS-GAIQVLTSFP---REVREVWSDSEHNFLDENIGGVAVAPAHGSILIECARRELHATTPLKKPNR 370

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243 1557 CHPTRISLVFYQHKNLNQPNHGLALWEAKMKQLAERARQRQEEAARLGLgQQEAKLYGKKRKWGGAMVAEPQHKEKKGAI 1636
Cdd:cd18897   371 CHPTRISLVFYQHKNLNQPNHGLALWEAKMKLLAERARARQEEAARLGL-QQEIKPYGKKRKWGGAPAAEPQPKEKKDKI 449


                  ...
gi 256773243 1637 PTR 1639
Cdd:cd18897   450 PTR 452
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 162-625 2.96e-08

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.18  E-value: 2.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  162 QGRPRLPGALPPSEAGLPAPSTRPPllSSEVPQVPPLEGLPLSQSALSiakeknislQTAIAIEALTQLSSALPQPSHST 241
Cdd:PHA03247 2595 SARPRAPVDDRGDPRGPAPPSPLPP--DTHAPDPPPPSPSPAANEPDP---------HPPPTVPPPERPRDDPAPGRVSR 2663

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  242 SQASCPLPEALSPSAPFRSPQ-SYLRAPSWPVV----PPEEHPSFAPDSPAFPPATPRPEFSEAWGTDTPPATprnSWPV 316
Cdd:PHA03247 2664 PRRARRLGRAAQASSPPQRPRrRAARPTVGSLTsladPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALP---AAPA 2740

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  317 PRPSPDpmaeleqllGSASDYIQSVFKRPEAL-----PTKPKVKVEAPSSSPAPVPSPISQREAPLLSSEPDTHQKAQTA 391
Cdd:PHA03247 2741 PPAVPA---------GPATPGGPARPARPPTTagppaPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAV 2811

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  392 LqqhlhhkrnlfleqAQDASFPTSTEPQAPgwwaPPGSPAPRPPDKPPKEKKKKPPTPAGGPVgaektTPGIKTSVRKPI 471
Cdd:PHA03247 2812 L--------------APAAALPPAASPAGP----LPPPTSAQPTAPPPPPGPPPPSLPLGGSV-----APGGDVRRRPPS 2868

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  472 QikKSRSRDMQPLFLPVRQIVleglKPQASEGQAPLP-AQLSVPPPASQGAASQSCATPLTPEPSLALFAPSPSGDSLLP 550
Cdd:PHA03247 2869 R--SPAAKPAAPARPPVRRLA----RPAVSRSTESFAlPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPP 2942

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 256773243  551 PtqemrSPSPMVALQSGSTGGPLPPADDKLeelirqfeaefgdsfgLPGPPSVPIQEPENQSTCLPAPESPFATR 625
Cdd:PHA03247 2943 L-----APTTDPAGAGEPSGAVPQPWLGAL----------------VPGRVAVPRFRVPQPAPSREAPASSTPPL 2996
 
Name Accession Description Interval E-value
TET3 cd18897
oxygenase domain of ten-eleven translocation (TET)3 methylcytosine dioxygenase and similar ...
 701-1025 0e+00

oxygenase domain of ten-eleven translocation (TET)3 methylcytosine dioxygenase and similar proteins; TET3 is involved in DNA demethylation through iteratively oxidizing 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). TET proteins contain a C-terminal catalytic domain which consists of a cysteine-rich region and a double-stranded beta-helix (DSBH) fold. TET3 serves as a tumor suppressor; it acts as a suppressor of ovarian cancer by demethylating the miR-30d precursor gene promoter to block TGF-beta1 induced epithelial-mesenchymal transition (EMT). TET3 (and TET2) promoters are silenced in melanoma cells by mechanisms triggered by TGF-beta and mediated by DNA methyltransferase 3 alpha (DNMT3A), which play a functional role in the EMT process and metastasis. In addition, TET3 (and TET2) may be guardians of regulatory T cell stability and immune homeostasis. TET3 has been shown to prevent terminal differentiation of adult neural stem cells by a mechanism involving direct binding and repression of TET3 to the imprinted gene Snrpn. TET3 has also been shown to mediate the activation of hepatic stellate cells via modulation of the long non-coding RNA HIF1A-AS1 expression. TET1 belongs to the TET/JBP family of dioxygenases that require Fe2+ and alpha-ketoglutarate (also known as 2-oxoglutarate) for activity.


Pssm-ID: 380676  Cd Length: 452  Bit Score: 726.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  701 CDCVEQIVEKDEGPYYTHLGSGPTVASIRELMEDRYGEKGKAIRIEKVIYTGKEGKSSRGCPIAKWVIRRHTLEEKLLCL 780
Cdd:cd18897     1 CDCVEQILEKDEGPYYTHLGSGPTVASIRELMEERYGEKGKAIRIEKVIYTGKEGKSSRGCPIAKWVIRRSSEEEKLLCL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  781 VRHRAGHHCQNAVIVILILAWEGIPRSLGDTLYQELTDTLRKYGNPTSRRCGLNDDRTCACQGKDPNTCGASFSFGCSWS 860
Cdd:cd18897    81 VRHRAGHHCQNAVIVILILAWEGIPRALGDKLYQELTETLTKYGNPTSRRCGLNDDRTCACQGKDPNTCGASFSFGCSWS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  861 MYFNGCKYARSKTPRKFRLTGDNPKEEEVLRNSFQDLATEVAPLYKRLAPQAYQNQVTNEDVAIDCRLGLKEGRPFSGVT 940
Cdd:cd18897   161 MYFNGCKYARSKTPRKFRLIGDNPKEEENLRDNFQDLATEVAPLYKRLAPQAYQNQVTNEDIAIDCRLGLKEGRPFSGVT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  941 ACMDFCAHAHKDQHNLYNGCTVVCTLTKEDNRCVGQIPEDEQLHVLPLYKMASTDEFGSEENQNAKVSSGAIQVLTAFPR 1020
Cdd:cd18897   241 ACMDFCAHAHKDQHNLYNGCTVVCTLTKEDNRTVGKIPEDEQLHVLPLYKMSTTDEFGSEENQNEKIGSGAIQVLTSFPR 320


                  ....*
gi 256773243 1021 EVRRL 1025
Cdd:cd18897   321 EVREV 325
TET3 cd18897
oxygenase domain of ten-eleven translocation (TET)3 methylcytosine dioxygenase and similar ...
 1477-1639 2.24e-81

oxygenase domain of ten-eleven translocation (TET)3 methylcytosine dioxygenase and similar proteins; TET3 is involved in DNA demethylation through iteratively oxidizing 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). TET proteins contain a C-terminal catalytic domain which consists of a cysteine-rich region and a double-stranded beta-helix (DSBH) fold. TET3 serves as a tumor suppressor; it acts as a suppressor of ovarian cancer by demethylating the miR-30d precursor gene promoter to block TGF-beta1 induced epithelial-mesenchymal transition (EMT). TET3 (and TET2) promoters are silenced in melanoma cells by mechanisms triggered by TGF-beta and mediated by DNA methyltransferase 3 alpha (DNMT3A), which play a functional role in the EMT process and metastasis. In addition, TET3 (and TET2) may be guardians of regulatory T cell stability and immune homeostasis. TET3 has been shown to prevent terminal differentiation of adult neural stem cells by a mechanism involving direct binding and repression of TET3 to the imprinted gene Snrpn. TET3 has also been shown to mediate the activation of hepatic stellate cells via modulation of the long non-coding RNA HIF1A-AS1 expression. TET1 belongs to the TET/JBP family of dioxygenases that require Fe2+ and alpha-ketoglutarate (also known as 2-oxoglutarate) for activity.


Pssm-ID: 380676  Cd Length: 452  Bit Score: 276.10  E-value: 2.24e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243 1477 DPFSLEEGTAEEPPSkGVVKEEKSGPtveEDEEELWSDSEHNFLDENIGGVAVAPAHCSILIECARRELHATTPLKKPNR 1556
Cdd:cd18897   295 DEFGSEENQNEKIGS-GAIQVLTSFP---REVREVWSDSEHNFLDENIGGVAVAPAHGSILIECARRELHATTPLKKPNR 370

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243 1557 CHPTRISLVFYQHKNLNQPNHGLALWEAKMKQLAERARQRQEEAARLGLgQQEAKLYGKKRKWGGAMVAEPQHKEKKGAI 1636
Cdd:cd18897   371 CHPTRISLVFYQHKNLNQPNHGLALWEAKMKLLAERARARQEEAARLGL-QQEIKPYGKKRKWGGAPAAEPQPKEKKDKI 449


                  ...
gi 256773243 1637 PTR 1639
Cdd:cd18897   450 PTR 452
Tet_JBP pfam12851
Oxygenase domain of the 2OGFeDO superfamily; A double-stranded beta helix (DSBH) fold domain ...
 858-985 5.01e-45

Oxygenase domain of the 2OGFeDO superfamily; A double-stranded beta helix (DSBH) fold domain of the 2-oxoglutarate (2OG)-Fe(II)-dependent dioxygenase (2OGFeDO) superfamily found in various eukaryotes, bacteria and bacteriophages. Members of this family catalyze nucleic acid modifications, such as thymidine hydroxylation during base J synthesis in kinetoplastids, and the conversion of 5 methyl-cytosine (5-mC) to 5-hydroxymethyl-cytosine (hmC), or further oxidation to 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). Metazoan TET proteins contain a cysteine-rich region inserted into the core of the DSBH fold. Vertebrate TET proteins are oncogenes that are mutated in various myeloid cancers. Fungal and algal versions of this family are linked to a predicted transposase and show lineage-specific expansions.


Pssm-ID: 372343  Cd Length: 166  Bit Score: 160.62  E-value: 5.01e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243   858 SWSMYFNGCKYARSKTPRKFRLTGDNPKEEEVLRNSFQDLATEVAPLYKRLAPQAYQNQVTNEDVAIDCRLGLKEGRPFS 937
Cdd:pfam12851    1 SWSMYYDGCKFPGPRKPRKFSFTPRNPKEEIKLEDELQELAALLGAIYKQIAPDLYENQIEYEQDAAICRLGRKWGRPFS 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 256773243   938 GVTACMDFCAHAHKDQHNLYNGCTVVCTLTkedNRCVGQIPEDEQLHV 985
Cdd:pfam12851   81 GVTVNLNFETISHRDLGNFRNGSTLLCTLT---GRYEGGRLALPQLGV 125
Tet_JBP pfam12851
Oxygenase domain of the 2OGFeDO superfamily; A double-stranded beta helix (DSBH) fold domain ...
 1526-1570 8.20e-10

Oxygenase domain of the 2OGFeDO superfamily; A double-stranded beta helix (DSBH) fold domain of the 2-oxoglutarate (2OG)-Fe(II)-dependent dioxygenase (2OGFeDO) superfamily found in various eukaryotes, bacteria and bacteriophages. Members of this family catalyze nucleic acid modifications, such as thymidine hydroxylation during base J synthesis in kinetoplastids, and the conversion of 5 methyl-cytosine (5-mC) to 5-hydroxymethyl-cytosine (hmC), or further oxidation to 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). Metazoan TET proteins contain a cysteine-rich region inserted into the core of the DSBH fold. Vertebrate TET proteins are oncogenes that are mutated in various myeloid cancers. Fungal and algal versions of this family are linked to a predicted transposase and show lineage-specific expansions.


Pssm-ID: 372343  Cd Length: 166  Bit Score: 59.32  E-value: 8.20e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 256773243  1526 GVAVAPAHCSILIECARRELHATTPLKKPNRchPTRISLVFYQHK 1570
Cdd:pfam12851  124 GVAFAPTPGTVLIFCGKSLEHGVTPVKNPNR--WERVSLVFYWHK 166
PHA03247 PHA03247
large tegument protein UL36; Provisional
 162-625 2.96e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.18  E-value: 2.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  162 QGRPRLPGALPPSEAGLPAPSTRPPllSSEVPQVPPLEGLPLSQSALSiakeknislQTAIAIEALTQLSSALPQPSHST 241
Cdd:PHA03247 2595 SARPRAPVDDRGDPRGPAPPSPLPP--DTHAPDPPPPSPSPAANEPDP---------HPPPTVPPPERPRDDPAPGRVSR 2663

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  242 SQASCPLPEALSPSAPFRSPQ-SYLRAPSWPVV----PPEEHPSFAPDSPAFPPATPRPEFSEAWGTDTPPATprnSWPV 316
Cdd:PHA03247 2664 PRRARRLGRAAQASSPPQRPRrRAARPTVGSLTsladPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALP---AAPA 2740

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  317 PRPSPDpmaeleqllGSASDYIQSVFKRPEAL-----PTKPKVKVEAPSSSPAPVPSPISQREAPLLSSEPDTHQKAQTA 391
Cdd:PHA03247 2741 PPAVPA---------GPATPGGPARPARPPTTagppaPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAV 2811

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  392 LqqhlhhkrnlfleqAQDASFPTSTEPQAPgwwaPPGSPAPRPPDKPPKEKKKKPPTPAGGPVgaektTPGIKTSVRKPI 471
Cdd:PHA03247 2812 L--------------APAAALPPAASPAGP----LPPPTSAQPTAPPPPPGPPPPSLPLGGSV-----APGGDVRRRPPS 2868

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  472 QikKSRSRDMQPLFLPVRQIVleglKPQASEGQAPLP-AQLSVPPPASQGAASQSCATPLTPEPSLALFAPSPSGDSLLP 550
Cdd:PHA03247 2869 R--SPAAKPAAPARPPVRRLA----RPAVSRSTESFAlPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPP 2942

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 256773243  551 PtqemrSPSPMVALQSGSTGGPLPPADDKLeelirqfeaefgdsfgLPGPPSVPIQEPENQSTCLPAPESPFATR 625
Cdd:PHA03247 2943 L-----APTTDPAGAGEPSGAVPQPWLGAL----------------VPGRVAVPRFRVPQPAPSREAPASSTPPL 2996
 
Name Accession Description Interval E-value
TET3 cd18897
oxygenase domain of ten-eleven translocation (TET)3 methylcytosine dioxygenase and similar ...
 701-1025 0e+00

oxygenase domain of ten-eleven translocation (TET)3 methylcytosine dioxygenase and similar proteins; TET3 is involved in DNA demethylation through iteratively oxidizing 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). TET proteins contain a C-terminal catalytic domain which consists of a cysteine-rich region and a double-stranded beta-helix (DSBH) fold. TET3 serves as a tumor suppressor; it acts as a suppressor of ovarian cancer by demethylating the miR-30d precursor gene promoter to block TGF-beta1 induced epithelial-mesenchymal transition (EMT). TET3 (and TET2) promoters are silenced in melanoma cells by mechanisms triggered by TGF-beta and mediated by DNA methyltransferase 3 alpha (DNMT3A), which play a functional role in the EMT process and metastasis. In addition, TET3 (and TET2) may be guardians of regulatory T cell stability and immune homeostasis. TET3 has been shown to prevent terminal differentiation of adult neural stem cells by a mechanism involving direct binding and repression of TET3 to the imprinted gene Snrpn. TET3 has also been shown to mediate the activation of hepatic stellate cells via modulation of the long non-coding RNA HIF1A-AS1 expression. TET1 belongs to the TET/JBP family of dioxygenases that require Fe2+ and alpha-ketoglutarate (also known as 2-oxoglutarate) for activity.


Pssm-ID: 380676  Cd Length: 452  Bit Score: 726.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  701 CDCVEQIVEKDEGPYYTHLGSGPTVASIRELMEDRYGEKGKAIRIEKVIYTGKEGKSSRGCPIAKWVIRRHTLEEKLLCL 780
Cdd:cd18897     1 CDCVEQILEKDEGPYYTHLGSGPTVASIRELMEERYGEKGKAIRIEKVIYTGKEGKSSRGCPIAKWVIRRSSEEEKLLCL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  781 VRHRAGHHCQNAVIVILILAWEGIPRSLGDTLYQELTDTLRKYGNPTSRRCGLNDDRTCACQGKDPNTCGASFSFGCSWS 860
Cdd:cd18897    81 VRHRAGHHCQNAVIVILILAWEGIPRALGDKLYQELTETLTKYGNPTSRRCGLNDDRTCACQGKDPNTCGASFSFGCSWS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  861 MYFNGCKYARSKTPRKFRLTGDNPKEEEVLRNSFQDLATEVAPLYKRLAPQAYQNQVTNEDVAIDCRLGLKEGRPFSGVT 940
Cdd:cd18897   161 MYFNGCKYARSKTPRKFRLIGDNPKEEENLRDNFQDLATEVAPLYKRLAPQAYQNQVTNEDIAIDCRLGLKEGRPFSGVT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  941 ACMDFCAHAHKDQHNLYNGCTVVCTLTKEDNRCVGQIPEDEQLHVLPLYKMASTDEFGSEENQNAKVSSGAIQVLTAFPR 1020
Cdd:cd18897   241 ACMDFCAHAHKDQHNLYNGCTVVCTLTKEDNRTVGKIPEDEQLHVLPLYKMSTTDEFGSEENQNEKIGSGAIQVLTSFPR 320


                  ....*
gi 256773243 1021 EVRRL 1025
Cdd:cd18897   321 EVREV 325
TET cd18892
oxygenase domain of ten-eleven translocation (TET)1, TET2, and TET3 methylcytosine ...
 701-1035 0e+00

oxygenase domain of ten-eleven translocation (TET)1, TET2, and TET3 methylcytosine dioxygenases and similar proteins; TET proteins are involved in DNA demethylation through iteratively oxidizing 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). TET proteins contain a C-terminal catalytic domain which consists of a cysteine-rich region and a double-stranded beta-helix (DSBH) fold. Alterations in TET protein function have been linked to cancer, and TETs influence many cell differentiation processes. TET family genes have been implicated as tumor suppressors, for example mutations/deletions of the TET2 gene frequently occur in multiple spectra of myeloid malignancies. TET3 acts as a suppressor of ovarian cancer by demethylating the miR-30d precursor gene promoter to block TGF-beta1 induced epithelial-mesenchymal transition (EMT). TET3 (and TET2) promoters are silenced in melanoma cells by mechanisms triggered by TGF-beta and mediated by DNA methyltransferase 3 alpha (DNMT3A). TET genes are downregulated in endometriosis. TET proteins belong to the TET/JBP family of dioxygenases that require Fe2+ and alpha-ketoglutarate (also known as 2-oxoglutarate) for activity.


Pssm-ID: 380671  Cd Length: 398  Bit Score: 662.06  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  701 CDCVEQIV-EKDEGPYYTHLGSGPTVASIRELMEDRYGEKGKAIRIEKVIYTGKEGKSSRGCPIAKWVIRRHTLEEKLLC 779
Cdd:cd18892     1 CGCFPPDEsPPEPGPYYTHLGAGPSLAALRELLEKRTGVTGKAIRIEKVIYTGKEGKTSQGCPIAKWIIRRSSLEEKYLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  780 LVRHRAGHHCQNAVIVILILAWEGIPRSLGDTLYQELTDTLRKYGNPTSRRCGLNDDRTCACQGKDPNTCGASFSFGCSW 859
Cdd:cd18892    81 LVKHRPGHFCHSAFIVICIVAWEGVPQSNADELYSLLTDKLNKFGLPTKRRCGTNEERTCACQGLDPETCGASFSFGCSW 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  860 SMYFNGCKYARSKTPRKFRLTGdnPKEEEVLRNSFQDLATEVAPLYKRLAPQAYQNQVTNEDVAIDCRLGLKEGRPFSGV 939
Cdd:cd18892   161 SMYYNGCKFARSKTVRKFRLSD--KSEEEELEDKLQNLATHLAPLYKSLAPDSYKNQVQFEEEALDCRLGLKPGRPFSGV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  940 TACMDFCAHAHKDQHNLYNGCTVVCTLTKEDNRCvGQIPEDEQLHVLPLYKMASTDEFGSEENQNAKVSSGAIQVLTAFP 1019
Cdd:cd18892   239 TACVDFCAHAHKDLHNMNNGCTVVVTLTKHRNLT-KPEPEQLHVLPLYLYDMTDEDEFGSVEGQEEKVRNGSIEVLTKYP 317

                         330
                  ....*....|....*.
gi 256773243 1020 REVRRLPEPAKSCRQR 1035
Cdd:cd18892   318 CEVREYWSDSEECFLD 333
TET1 cd18895
oxygenase domain of ten-eleven translocation (TET)1 methylcytosine dioxygenase and similar ...
 701-1025 0e+00

oxygenase domain of ten-eleven translocation (TET)1 methylcytosine dioxygenase and similar proteins; TET1 is involved in DNA demethylation through iteratively oxidizing 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). Human TET1 (and TET2) are more active on 5mC-DNA than 5hmC/5fC-DNA substrates. TET proteins contain a C-terminal catalytic domain which consists of a cysteine-rich region and a double-stranded beta-helix (DSBH) fold. TET1 plays multiple roles in in tumor development and progression. TET1 serves as a tumor suppressor gene; loss of TET1 is associated with tumorigenesis and can be used as a potential biomarker for cancer therapy. In addition to its dioxygenase activity, it can induce epithelial-mesenchymal transition and act as a coactivator to regulate gene transcription. The regulation of TET1 is also correlated with microRNA in a posttranscriptional modification process. TET1 belongs to the TET/JBP family of dioxygenases that require Fe2+ and alpha-ketoglutarate (also known as 2-oxoglutarate) for activity.


Pssm-ID: 380674  Cd Length: 410  Bit Score: 621.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  701 CDCVEQIVEKDEGPYYTHLGSGPTVASIRELMEDRYGEKGKAIRIEKVIYTGKEGKSSRGCPIAKWVIRRHTLEEKLLCL 780
Cdd:cd18895     1 CDCVEQIIEKDEGPYYTHLGAGPSVAAVREIMENRYGEKGNAIRIEVVVYTGKEGKSSQGCPIAKWVIRRSSDEEKLLCL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  781 VRHRAGHHCQNAVIVILILAWEGIPRSLGDTLYQELTDTLRKYGNPTSRRCGLNDDRTCACQGKDPNTCGASFSFGCSWS 860
Cdd:cd18895    81 VRQRAGHHCQTAVIVILILAWEGIPRLLADRLYQELTQTLKKYGSPTSRRCALNEDRTCACQGLDPETCGASFSFGCSWS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  861 MYFNGCKYARSKTPRKFRLTGDNPKEEEVLRNSFQDLATEVAPLYKRLAPQAYQNQVTNEDVAIDCRLGLKEGRPFSGVT 940
Cdd:cd18895   161 MYFNGCKFARSKYPRKFRLLTDDPKEEENLESNLQNLATDVAPVYKKLAPEAFQNQVENENVAPDCRLGSKEGRPFSGVT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  941 ACMDFCAHAHKDQHNLYNGCTVVCTLTKEDNRCVGQIPEDEQLHVLPLYKMASTDEFGSEENQNAKVSSGAIQVLTAFPR 1020
Cdd:cd18895   241 ACIDFCAHAHKDTHNMHNGSTVVCTLTKEDNRSVGVIPEDEQLHVLPLYKISDTDEFGSEEGQEAKIKNGAIQVLSAFPR 320


                  ....*
gi 256773243 1021 EVRRL 1025
Cdd:cd18895   321 EVREV 325
TET2 cd18896
oxygenase domain of ten-eleven translocation (TET)2 methylcytosine dioxygenase and similar ...
 697-1037 0e+00

oxygenase domain of ten-eleven translocation (TET)2 methylcytosine dioxygenase and similar proteins; TET2 is involved in DNA demethylation through iteratively oxidizing 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). Human TET2 (and TET1) have been shown to be more active on 5mC-DNA than 5hmC/5fC-DNA substrates. TET proteins contain a C-terminal catalytic domain which consists of a cysteine-rich region and a double-stranded beta-helix (DSBH) fold. TET2 acts as a tumor suppressor in hematopoiesis; mutations/deletions of the TET2 gene frequently occur in multiple spectra of myeloid malignancies. TET2 (and TET3) promoters are silenced in melanoma cells by mechanisms triggered by TGF-beta and mediated by DNA methyltransferase 3 alpha (DNMT3A), which play a functional role in the epithelial-mesenchymal transition process and metastasis. In addition, TET2 (and TET3) may be guardians of regulatory T cell stability and immune homeostasis. TET2 belongs to the TET/JBP family of dioxygenases that require Fe2+ and alpha-ketoglutarate (also known as 2-oxoglutarate) for activity.


Pssm-ID: 380675  Cd Length: 434  Bit Score: 613.52  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  697 EFPTCDCVEQIVEKDEGPYYTHLGSGPTVASIRELMEDRYGEKGKAIRIEKVIYTGKEGKSSRGCPIAKWVIRRHTLEEK 776
Cdd:cd18896     1 DFPSCSCVEQIIEKDEGPYYTHLGAGPNVAAIREIMEERFGQKGKAIRIERVIYTGKEGKSSQGCPIAKWVIRRSSEEEK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  777 LLCLVRHRAGHHCQNAVIVILILAWEGIPRSLGDTLYQELTDTLRKYGNPTSRRCGLNDDRTCACQGKDPNTCGASFSFG 856
Cdd:cd18896    81 LLCLVRERAGHSCETAVIVILILVWEGIPISLADKLYSELTDTLRKYGTLTNRRCALNEERTCACQGLDPETCGASFSFG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  857 CSWSMYFNGCKYARSKTPRKFRLTGDNPKEEEVLRNSFQDLATEVAPLYKRLAPQAYQNQVTNEDVAIDCRLGLKEGRPF 936
Cdd:cd18896   161 CSWSMYYNGCKFARSKIPRKFKLLGDDPKEEEKLESNLQNLSTLMAPTYKKLAPDAYNNQIEYEHRAPDCRLGLKEGRPF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  937 SGVTACMDFCAHAHKDQHNLYNGCTVVCTLTKEDNRCVGQIPEDEQLHVLPLYKMASTDEFGSEENQNAKVSSGAIQVLT 1016
Cdd:cd18896   241 SGVTACLDFCAHAHRDLHNMQNGSTLVCTLTREDNREIGKIPEDEQLHVLPLYKVSDVDEFGSTEAQEEKKRNGAIQVLS 320

                         330       340
                  ....*....|....*....|.
gi 256773243 1017 AFPREVRRLPEPAKSCRQRQL 1037
Cdd:cd18896   321 SFRRKVRMLAEPVKTCRQRKL 341
TET3 cd18897
oxygenase domain of ten-eleven translocation (TET)3 methylcytosine dioxygenase and similar ...
 1477-1639 2.24e-81

oxygenase domain of ten-eleven translocation (TET)3 methylcytosine dioxygenase and similar proteins; TET3 is involved in DNA demethylation through iteratively oxidizing 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). TET proteins contain a C-terminal catalytic domain which consists of a cysteine-rich region and a double-stranded beta-helix (DSBH) fold. TET3 serves as a tumor suppressor; it acts as a suppressor of ovarian cancer by demethylating the miR-30d precursor gene promoter to block TGF-beta1 induced epithelial-mesenchymal transition (EMT). TET3 (and TET2) promoters are silenced in melanoma cells by mechanisms triggered by TGF-beta and mediated by DNA methyltransferase 3 alpha (DNMT3A), which play a functional role in the EMT process and metastasis. In addition, TET3 (and TET2) may be guardians of regulatory T cell stability and immune homeostasis. TET3 has been shown to prevent terminal differentiation of adult neural stem cells by a mechanism involving direct binding and repression of TET3 to the imprinted gene Snrpn. TET3 has also been shown to mediate the activation of hepatic stellate cells via modulation of the long non-coding RNA HIF1A-AS1 expression. TET1 belongs to the TET/JBP family of dioxygenases that require Fe2+ and alpha-ketoglutarate (also known as 2-oxoglutarate) for activity.


Pssm-ID: 380676  Cd Length: 452  Bit Score: 276.10  E-value: 2.24e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243 1477 DPFSLEEGTAEEPPSkGVVKEEKSGPtveEDEEELWSDSEHNFLDENIGGVAVAPAHCSILIECARRELHATTPLKKPNR 1556
Cdd:cd18897   295 DEFGSEENQNEKIGS-GAIQVLTSFP---REVREVWSDSEHNFLDENIGGVAVAPAHGSILIECARRELHATTPLKKPNR 370

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243 1557 CHPTRISLVFYQHKNLNQPNHGLALWEAKMKQLAERARQRQEEAARLGLgQQEAKLYGKKRKWGGAMVAEPQHKEKKGAI 1636
Cdd:cd18897   371 CHPTRISLVFYQHKNLNQPNHGLALWEAKMKLLAERARARQEEAARLGL-QQEIKPYGKKRKWGGAPAAEPQPKEKKDKI 449


                  ...
gi 256773243 1637 PTR 1639
Cdd:cd18897   450 PTR 452
Tet_JBP cd14946
oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and ...
 728-990 2.94e-58

oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins; TET proteins are involved in DNA demethylation through iteratively oxidizing 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). TET proteins contain a C-terminal catalytic domain which consists of a cysteine-rich region and a double-stranded beta-helix (DSBH) fold. Alterations in TET protein function have been linked to cancer, and TETs influence many cell differentiation processes. J binding protein (JBP) 1 and JBP2 are thymidine hydroxylases that catalyze the first step of base J biosynthesis: the hydroxylation of thymine in DNA to form 5-hydroxymethyluracil (hmU). Base J (beta-d-glucopyranosyloxymethyluracil) is a hyper-modified DNA base found in the DNA of kinetoplastids (Trypanosoma brucei, Trypanosoma cruzi, and Leishmania). JBP1 and JBP2 each contain a J-DNA binding domain and a thymidine hydroxylase domain. Members of this TET/JBP family of dioxygenases require Fe2+ and alpha-ketoglutarate (also known as 2-oxoglutarate) for activity.


Pssm-ID: 380670  Cd Length: 264  Bit Score: 202.23  E-value: 2.94e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  728 IRELMEDRYG-EKGKAIRIEKVIYTGKEGKSsRGCPIAKWVIRRhtleEKLLCLVRHRAGhhcqnavIVILILAWEGIPR 806
Cdd:cd14946     1 LLENMLSKCGtQQSFANANITLKYEGKEGKS-QGCPKALKNVRT----SKLAYFVCDHDG-------SVILAYVPEVLPK 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  807 SLGDTLYQELTDTLRKYGNptsrrcglnddrtcacqgKDPNTCGASFSFGCSWSMYFNGCKyarsktprkfRLTGDNPKE 886
Cdd:cd14946    69 ELVEEFTEKLESIQTKRGT------------------LDPETKGDTGYSGILDNSMPFNYV----------TADLSQELG 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  887 EEVLRNSFQDLATEVAPLYKRLAPQAYQNQVTNEDVAIDCRLGLKEGRPFSGVTACMD-FCAHAHKDQHNLYNGCTVVCT 965
Cdd:cd14946   121 QYLSEIVNPQISYYISKLLTCVSPRTINYLVEYEHRSLNDSYYALNNCLYPSTAFNSLkRIRKPHKDNLDIQNGPSSLFY 200

                         250       260
                  ....*....|....*....|....*
gi 256773243  966 LTKEDNrcvgqipeDEQLHVLPLYK 990
Cdd:cd14946   201 FGNFQN--------TEGYLELTLKK 217
TET2 cd18896
oxygenase domain of ten-eleven translocation (TET)2 methylcytosine dioxygenase and similar ...
 1508-1603 1.11e-47

oxygenase domain of ten-eleven translocation (TET)2 methylcytosine dioxygenase and similar proteins; TET2 is involved in DNA demethylation through iteratively oxidizing 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). Human TET2 (and TET1) have been shown to be more active on 5mC-DNA than 5hmC/5fC-DNA substrates. TET proteins contain a C-terminal catalytic domain which consists of a cysteine-rich region and a double-stranded beta-helix (DSBH) fold. TET2 acts as a tumor suppressor in hematopoiesis; mutations/deletions of the TET2 gene frequently occur in multiple spectra of myeloid malignancies. TET2 (and TET3) promoters are silenced in melanoma cells by mechanisms triggered by TGF-beta and mediated by DNA methyltransferase 3 alpha (DNMT3A), which play a functional role in the epithelial-mesenchymal transition process and metastasis. In addition, TET2 (and TET3) may be guardians of regulatory T cell stability and immune homeostasis. TET2 belongs to the TET/JBP family of dioxygenases that require Fe2+ and alpha-ketoglutarate (also known as 2-oxoglutarate) for activity.


Pssm-ID: 380675  Cd Length: 434  Bit Score: 177.47  E-value: 1.11e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243 1508 EEELWSDSEHNFLDENIGGVAVAPAHCSILIECARRELHATTPLKKPNRCHPTRISLVFYQHKNLNQPNHGLALWEAKMk 1587
Cdd:cd18896   342 EDEVWSDSEQSFLDPDIGGVAVAPSHGSILIECAKRELHATTPLKNPNRNHPTRISLVFYQHKSMNEPKHGLALWEAKM- 420

                          90
                  ....*....|....*.
gi 256773243 1588 qlAERARQRQEEAARL 1603
Cdd:cd18896   421 --AEKAREKEEECEKY 434
TET1 cd18895
oxygenase domain of ten-eleven translocation (TET)1 methylcytosine dioxygenase and similar ...
 1477-1599 2.24e-46

oxygenase domain of ten-eleven translocation (TET)1 methylcytosine dioxygenase and similar proteins; TET1 is involved in DNA demethylation through iteratively oxidizing 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). Human TET1 (and TET2) are more active on 5mC-DNA than 5hmC/5fC-DNA substrates. TET proteins contain a C-terminal catalytic domain which consists of a cysteine-rich region and a double-stranded beta-helix (DSBH) fold. TET1 plays multiple roles in in tumor development and progression. TET1 serves as a tumor suppressor gene; loss of TET1 is associated with tumorigenesis and can be used as a potential biomarker for cancer therapy. In addition to its dioxygenase activity, it can induce epithelial-mesenchymal transition and act as a coactivator to regulate gene transcription. The regulation of TET1 is also correlated with microRNA in a posttranscriptional modification process. TET1 belongs to the TET/JBP family of dioxygenases that require Fe2+ and alpha-ketoglutarate (also known as 2-oxoglutarate) for activity.


Pssm-ID: 380674  Cd Length: 410  Bit Score: 172.79  E-value: 2.24e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243 1477 DPFSLEEGTaEEPPSKGVVKEEKSGPtveEDEEELWSDSEHNFLDENIGGVAVAPAHCSILIECARRELHATTPLKKPNR 1556
Cdd:cd18895   295 DEFGSEEGQ-EAKIKNGAIQVLSAFP---REVREVWSDSEHNFLDEDIGGVAVAPSHGSILIECARRELHATTPIKKPNR 370

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 256773243 1557 CHPTRISLVFYQHKNLNQPNHGLALWEAKMkqlAERARQRQEE 1599
Cdd:cd18895   371 NHPTRISLVFYQHKNLNEPKHGLALWEAKM---AEKAKEKEKE 410
Tet_JBP pfam12851
Oxygenase domain of the 2OGFeDO superfamily; A double-stranded beta helix (DSBH) fold domain ...
 858-985 5.01e-45

Oxygenase domain of the 2OGFeDO superfamily; A double-stranded beta helix (DSBH) fold domain of the 2-oxoglutarate (2OG)-Fe(II)-dependent dioxygenase (2OGFeDO) superfamily found in various eukaryotes, bacteria and bacteriophages. Members of this family catalyze nucleic acid modifications, such as thymidine hydroxylation during base J synthesis in kinetoplastids, and the conversion of 5 methyl-cytosine (5-mC) to 5-hydroxymethyl-cytosine (hmC), or further oxidation to 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). Metazoan TET proteins contain a cysteine-rich region inserted into the core of the DSBH fold. Vertebrate TET proteins are oncogenes that are mutated in various myeloid cancers. Fungal and algal versions of this family are linked to a predicted transposase and show lineage-specific expansions.


Pssm-ID: 372343  Cd Length: 166  Bit Score: 160.62  E-value: 5.01e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243   858 SWSMYFNGCKYARSKTPRKFRLTGDNPKEEEVLRNSFQDLATEVAPLYKRLAPQAYQNQVTNEDVAIDCRLGLKEGRPFS 937
Cdd:pfam12851    1 SWSMYYDGCKFPGPRKPRKFSFTPRNPKEEIKLEDELQELAALLGAIYKQIAPDLYENQIEYEQDAAICRLGRKWGRPFS 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 256773243   938 GVTACMDFCAHAHKDQHNLYNGCTVVCTLTkedNRCVGQIPEDEQLHV 985
Cdd:pfam12851   81 GVTVNLNFETISHRDLGNFRNGSTLLCTLT---GRYEGGRLALPQLGV 125
TET cd18892
oxygenase domain of ten-eleven translocation (TET)1, TET2, and TET3 methylcytosine ...
 1510-1586 1.91e-39

oxygenase domain of ten-eleven translocation (TET)1, TET2, and TET3 methylcytosine dioxygenases and similar proteins; TET proteins are involved in DNA demethylation through iteratively oxidizing 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). TET proteins contain a C-terminal catalytic domain which consists of a cysteine-rich region and a double-stranded beta-helix (DSBH) fold. Alterations in TET protein function have been linked to cancer, and TETs influence many cell differentiation processes. TET family genes have been implicated as tumor suppressors, for example mutations/deletions of the TET2 gene frequently occur in multiple spectra of myeloid malignancies. TET3 acts as a suppressor of ovarian cancer by demethylating the miR-30d precursor gene promoter to block TGF-beta1 induced epithelial-mesenchymal transition (EMT). TET3 (and TET2) promoters are silenced in melanoma cells by mechanisms triggered by TGF-beta and mediated by DNA methyltransferase 3 alpha (DNMT3A). TET genes are downregulated in endometriosis. TET proteins belong to the TET/JBP family of dioxygenases that require Fe2+ and alpha-ketoglutarate (also known as 2-oxoglutarate) for activity.


Pssm-ID: 380671  Cd Length: 398  Bit Score: 152.45  E-value: 1.91e-39
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 256773243 1510 ELWSDSEHNFLDENIGGVAVAPAHCSILIECARRELHATTPLKKPNRCHPTRISLVFYQHKNLNQPNHGLALWEAKM 1586
Cdd:cd18892   322 EYWSDSEECFLDPDIGGVAIALSHGSVLFECAKRELHATTPLKNPNRQHPTRISLVFYQHKNLNYSRHGLAEYEAKM 398
Tet_JBP cd14946
oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and ...
 1524-1570 1.23e-11

oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins; TET proteins are involved in DNA demethylation through iteratively oxidizing 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). TET proteins contain a C-terminal catalytic domain which consists of a cysteine-rich region and a double-stranded beta-helix (DSBH) fold. Alterations in TET protein function have been linked to cancer, and TETs influence many cell differentiation processes. J binding protein (JBP) 1 and JBP2 are thymidine hydroxylases that catalyze the first step of base J biosynthesis: the hydroxylation of thymine in DNA to form 5-hydroxymethyluracil (hmU). Base J (beta-d-glucopyranosyloxymethyluracil) is a hyper-modified DNA base found in the DNA of kinetoplastids (Trypanosoma brucei, Trypanosoma cruzi, and Leishmania). JBP1 and JBP2 each contain a J-DNA binding domain and a thymidine hydroxylase domain. Members of this TET/JBP family of dioxygenases require Fe2+ and alpha-ketoglutarate (also known as 2-oxoglutarate) for activity.


Pssm-ID: 380670  Cd Length: 264  Bit Score: 67.02  E-value: 1.23e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 256773243 1524 IGGVAVAPAHCSILIECARRELHATTPLKKPNRcHPTRISLVFYQHK 1570
Cdd:cd14946   219 IGNCAVFVQPGDVLFFKGNEYKHVVTNITNPNN-HGWRISLVYYAHK 264
Tet_JBP pfam12851
Oxygenase domain of the 2OGFeDO superfamily; A double-stranded beta helix (DSBH) fold domain ...
 1526-1570 8.20e-10

Oxygenase domain of the 2OGFeDO superfamily; A double-stranded beta helix (DSBH) fold domain of the 2-oxoglutarate (2OG)-Fe(II)-dependent dioxygenase (2OGFeDO) superfamily found in various eukaryotes, bacteria and bacteriophages. Members of this family catalyze nucleic acid modifications, such as thymidine hydroxylation during base J synthesis in kinetoplastids, and the conversion of 5 methyl-cytosine (5-mC) to 5-hydroxymethyl-cytosine (hmC), or further oxidation to 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). Metazoan TET proteins contain a cysteine-rich region inserted into the core of the DSBH fold. Vertebrate TET proteins are oncogenes that are mutated in various myeloid cancers. Fungal and algal versions of this family are linked to a predicted transposase and show lineage-specific expansions.


Pssm-ID: 372343  Cd Length: 166  Bit Score: 59.32  E-value: 8.20e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 256773243  1526 GVAVAPAHCSILIECARRELHATTPLKKPNRchPTRISLVFYQHK 1570
Cdd:pfam12851  124 GVAFAPTPGTVLIFCGKSLEHGVTPVKNPNR--WERVSLVFYWHK 166
PHA03247 PHA03247
large tegument protein UL36; Provisional
 162-625 2.96e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.18  E-value: 2.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  162 QGRPRLPGALPPSEAGLPAPSTRPPllSSEVPQVPPLEGLPLSQSALSiakeknislQTAIAIEALTQLSSALPQPSHST 241
Cdd:PHA03247 2595 SARPRAPVDDRGDPRGPAPPSPLPP--DTHAPDPPPPSPSPAANEPDP---------HPPPTVPPPERPRDDPAPGRVSR 2663

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  242 SQASCPLPEALSPSAPFRSPQ-SYLRAPSWPVV----PPEEHPSFAPDSPAFPPATPRPEFSEAWGTDTPPATprnSWPV 316
Cdd:PHA03247 2664 PRRARRLGRAAQASSPPQRPRrRAARPTVGSLTsladPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALP---AAPA 2740

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  317 PRPSPDpmaeleqllGSASDYIQSVFKRPEAL-----PTKPKVKVEAPSSSPAPVPSPISQREAPLLSSEPDTHQKAQTA 391
Cdd:PHA03247 2741 PPAVPA---------GPATPGGPARPARPPTTagppaPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAV 2811

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  392 LqqhlhhkrnlfleqAQDASFPTSTEPQAPgwwaPPGSPAPRPPDKPPKEKKKKPPTPAGGPVgaektTPGIKTSVRKPI 471
Cdd:PHA03247 2812 L--------------APAAALPPAASPAGP----LPPPTSAQPTAPPPPPGPPPPSLPLGGSV-----APGGDVRRRPPS 2868

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  472 QikKSRSRDMQPLFLPVRQIVleglKPQASEGQAPLP-AQLSVPPPASQGAASQSCATPLTPEPSLALFAPSPSGDSLLP 550
Cdd:PHA03247 2869 R--SPAAKPAAPARPPVRRLA----RPAVSRSTESFAlPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPP 2942

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 256773243  551 PtqemrSPSPMVALQSGSTGGPLPPADDKLeelirqfeaefgdsfgLPGPPSVPIQEPENQSTCLPAPESPFATR 625
Cdd:PHA03247 2943 L-----APTTDPAGAGEPSGAVPQPWLGAL----------------VPGRVAVPRFRVPQPAPSREAPASSTPPL 2996
PHA03247 PHA03247
large tegument protein UL36; Provisional
 249-700 2.98e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 2.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  249 PEALSPSAPFRSPQSYLRAPSWPVVPP---EEHPSFAPDSPAFPPATPRpefSEAW-------------------GTDTP 306
Cdd:PHA03247 2484 AEARFPFAAGAAPDPGGGGPPDPDAPPapsRLAPAILPDEPVGEPVHPR---MLTWirgleelasddagdpppplPPAAP 2560

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  307 PATPRNSWPVPRPSPDPmaeleqllgsASDYIQSVFKRPEALP--TKPKVKVEapssspapvPSPISQREAPLLSSEPDT 384
Cdd:PHA03247 2561 PAAPDRSVPPPRPAPRP----------SEPAVTSRARRPDAPPqsARPRAPVD---------DRGDPRGPAPPSPLPPDT 2621

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  385 HQkaqtalqqhlhhkrnlfLEQAQDASFPTSTEPQAPGWWAPPGSPAPRPPDKPPKEKKKKPPTPAGGPVGAEKTTPGIK 464
Cdd:PHA03247 2622 HA-----------------PDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPR 2684

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  465 TSVRKPIQIKKSRSRD-------MQPLFLPVRQIVLEGLKPQASEGQAPLPAQLSVPPPASQGAASQ-SCATPLTPEPSL 536
Cdd:PHA03247 2685 RRAARPTVGSLTSLADpppppptPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPgGPARPARPPTTA 2764

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  537 ALFAPSPSGDSLLPPTQemRSPSPMVALQSGSTGGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVPiqEPENQSTCLP 616
Cdd:PHA03247 2765 GPPAPAPPAAPAAGPPR--RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPP--PTSAQPTAPP 2840

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  617 APESPFATRSPKKIKIESSGAVtvlsttcfhSEEGGQEATPTKAENPLTPTLSGFLESPLKYLDTPTKSLLDTPAKKAQS 696
Cdd:PHA03247 2841 PPPGPPPPSLPLGGSVAPGGDV---------RRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQP 2911


                  ....
gi 256773243  697 EFPT 700
Cdd:PHA03247 2912 QAPP 2915
PHA03247 PHA03247
large tegument protein UL36; Provisional
 163-625 2.93e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 2.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  163 GRPRLPGALPPSEAGLPAPSTRPPLLSSEVP---QVPP--------LEGL----------PLSQSALSIAKEKNISLqta 221
Cdd:PHA03247 2494 AAPDPGGGGPPDPDAPPAPSRLAPAILPDEPvgePVHPrmltwirgLEELasddagdpppPLPPAAPPAAPDRSVPP--- 2570

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  222 iaiealtqlSSALPQPSHSTSQAscplpEALSPSAPfrsPQSYL-RAPSWPVVPPEEHPSFAPDSPAF-----PPATPRP 295
Cdd:PHA03247 2571 ---------PRPAPRPSEPAVTS-----RARRPDAP---PQSARpRAPVDDRGDPRGPAPPSPLPPDThapdpPPPSPSP 2633

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  296 EFSEAWGTDT----PPATPRNSWPVPRPSPDPMAELEQLLGSASDYIQSvfKRPEALPtkPKVKVEAPSSSPAPVPSPIS 371
Cdd:PHA03247 2634 AANEPDPHPPptvpPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQR--PRRRAAR--PTVGSLTSLADPPPPPPTPE 2709

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  372 QREAPLLSSEPDTHQKAqtalqqhlhhkrnlfleQAQDASFPTSTEPQAPgwwAPPGSPAPRPPDKPPKEKKKKPPTPAG 451
Cdd:PHA03247 2710 PAPHALVSATPLPPGPA-----------------AARQASPALPAAPAPP---AVPAGPATPGGPARPARPPTTAGPPAP 2769

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  452 GPVGAEKTTPGIKTSVrkPIQIKKSRSRDMQPLFLPVRQIVLEGLKPQASEGQAPLPAQLSVPPPASQGAASQSCATPlt 531
Cdd:PHA03247 2770 APPAAPAAGPPRRLTR--PAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGP-- 2845

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  532 PEPSLALF-APSPSGD-SLLPPTqemRSPSPMvalqsgstggPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVPIQEPE 609
Cdd:PHA03247 2846 PPPSLPLGgSVAPGGDvRRRPPS---RSPAAK----------PAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQ 2912

                         490
                  ....*....|....*.
gi 256773243  610 NQSTCLPAPESPFATR 625
Cdd:PHA03247 2913 APPPPQPQPQPPPPPQ 2928
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 208-348 4.23e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 48.27  E-value: 4.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  208 LSIAKEKNISLQTAIaIEALTQLSSAlPQPSHSTSQASCPLPEALSPSAPFRSPQSyLRAPSWPVVPPEEHPsfaPDSPA 287
Cdd:PRK14950  341 LRTTSYGQLPLELAV-IEALLVPVPA-PQPAKPTAAAPSPVRPTPAPSTRPKAAAA-ANIPPKEPVRETATP---PPVPP 414

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 256773243  288 FPPATPRPEFSEAWGTDTPPATPRNSWPVPRPSPDP----------MAELEQLLGSASDYIQSVFKRPEAL 348
Cdd:PRK14950  415 RPVAPPVPHTPESAPKLTRAAIPVDEKPKYTPPAPPkeeekaliadGDVLEQLEAIWKQILRDVPPRSPAV 485
PHA03247 PHA03247
large tegument protein UL36; Provisional
 13-326 4.82e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 4.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243   13 QLSTSGAPVNGAREPAGPGLLGAAGPwrVDQKPDWEAASGPTHAARLEDAHDLVAFSAVAEAVSSYGALSTRLYETFNRE 92
Cdd:PHA03247 2594 QSARPRAPVDDRGDPRGPAPPSPLPP--DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLG 2671

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243   93 MSREAGSNGRGPRPESCSEGSEDLDTLQTALALARHGMKPPNCTCDGPECPDFLEWLEGKIKSM-------------AME 159
Cdd:PHA03247 2672 RAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALpaapappavpagpATP 2751

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  160 GGQGRPRLPG--ALPPSEAGLPAPSTRPPLLSSEVPQVPPLEGLPLSQSALSIAKEKNISLQTAIAIEALTQLSSALPQP 237
Cdd:PHA03247 2752 GGPARPARPPttAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPP 2831

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  238 SHST----SQASCPLPEALS------PSAPFRSpqsylRAPSWPVVPPEEHPSFAPDSPAFPPATPRPEFSEAWGTDtPP 307
Cdd:PHA03247 2832 TSAQptapPPPPGPPPPSLPlggsvaPGGDVRR-----RPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPD-QP 2905

                         330
                  ....*....|....*....
gi 256773243  308 ATPRNSWPVPRPSPDPMAE 326
Cdd:PHA03247 2906 ERPPQPQAPPPPQPQPQPP 2924
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
453-626 6.22e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.48  E-value: 6.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  453 PVGAEKTTPGIKTSVRKPIQIKKSRSRDMQPLfLPVRQIVLEGLKPQASEGQAPLPAQLSVPPPASQGAASQSCATPLTP 532
Cdd:PRK12323  402 PPAAPAAAPAAAAAARAVAAAPARRSPAPEAL-AAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAP 480

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  533 EPSLALFAPSPSgDSLLPPTQEMRSPSPMVALQSGSTGGPLPPADDKLEELIRQFEAEFGDSfgLPGPPSVPIQEPENQS 612
Cdd:PRK12323  481 ARAAPAAAPAPA-DDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETL--APAPAAAPAPRAAAAT 557

                         170
                  ....*....|....
gi 256773243  613 TCLPAPESPFATRS 626
Cdd:PRK12323  558 EPVVAPRPPRASAS 571
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
160-379 3.34e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.17  E-value: 3.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  160 GGQGRPRLPGALPPSEaglPAPSTRPPLLSSEVPQVPPLEGLPLSQSALSIAKEKNISLQTAIAIEALtqlssalpqPSH 239
Cdd:PRK12323  369 GGGAGPATAAAAPVAQ---PAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEAL---------AAA 436

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  240 STSQASCPLPEALSPSAPFRSPQSYLRAPSWPVVPPeehpsfaPDSPAFPPATPRPEFSEAWGTDTPPATPRNSWPVPRP 319
Cdd:PRK12323  437 RQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPV-------AAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASP 509

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  320 SPDPMAELEQLLGSASDYIQSVFKRPEALPTKPKVKVEAPSSSPAPVPSPISQREAPLLS 379
Cdd:PRK12323  510 APAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRAS 569
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 181-576 4.50e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.08  E-value: 4.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  181 PSTRPPLLSSEVPQVPpLEGLPLSQSALSIAKEKNISLQTAIAIEALTQLSSALPQPSH--STSQASCPLPEALSPSAPF 258
Cdd:PHA03307   20 FFPRPPATPGDAADDL-LSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTeaPANESRSTPTWSLSTLAPA 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  259 RSPQSYLRAPSWPVVPPEEHPSFAPDSPAFPPATPRPEF------SEAWGTDTPPATPRNSWPVPRPSPDPmaeleqllG 332
Cdd:PHA03307   99 SPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMlrpvgsPGPPPAASPPAAGASPAAVASDAASS--------R 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  333 SASDYIQSVfkrPEALPTKPKVKVEAPSSSPAPVPSPISQREAPLLSSEPDTHQKAQTalqqhlhhkRNLFLEQAQDASF 412
Cdd:PHA03307  171 QAALPLSSP---EETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPG---------RSAADDAGASSSD 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  413 PTSTEPQAPGWWAPPGSPAPRPPDKPPKEKKKKPPTPAGGPVGAEKTTPGIKTSVRKPiqiKKSRSRDMQPLFLPVRQIV 492
Cdd:PHA03307  239 SSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSP---SPSPSSPGSGPAPSSPRAS 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  493 LEGLKPQASegqaplpaqlSVPPPASQGAASQSCATPLTPEPSLALFAPSPSGDSLLPPTQEMRSPSPMVALQSGSTGGP 572
Cdd:PHA03307  316 SSSSSSRES----------SSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRP 385


                  ....
gi 256773243  573 LPPA 576
Cdd:PHA03307  386 TRRR 389
dnaA PRK14086
chromosomal replication initiator protein DnaA;
163-326 5.27e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 41.35  E-value: 5.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  163 GRP-RLPGALPPSeAGLPAPSTRPPLLSSEvPQVP-----PLEGLPLSQ-SALSIAKEKNISLQTAI-AIEALTQLSSAL 234
Cdd:PRK14086   79 GRPiRIAITVDPS-AGEPAPPPPHARRTSE-PELPrpgrrPYEGYGGPRaDDRPPGLPRQDQLPTARpAYPAYQQRPEPG 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773243  235 PQPSHSTSQASCPLPEALSPSAPFRSPQSYLRAPSwpvvppeehpsfaPDSPafPPATPRPEFSEAWG---TDTPPATPR 311
Cdd:PRK14086  157 AWPRAADDYGWQQQRLGFPPRAPYASPASYAPEQE-------------RDRE--PYDAGRPEYDQRRRdydHPRPDWDRP 221

                         170
                  ....*....|....*
gi 256773243  312 NSWPVPRPSPDPMAE 326
Cdd:PRK14086  222 RRDRTDRPEPPPGAG 236
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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