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Conserved domains on  [gi|169791011|ref|NP_899112|]
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transcription elongation regulator 1-like protein [Mus musculus]

Protein Classification

WW domain-containing protein( domain architecture ID 13418196)

WW domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FF pfam01846
FF domain; This domain has been predicted to be involved in protein-protein interaction. This ...
 456-504 4.14e-11

FF domain; This domain has been predicted to be involved in protein-protein interaction. This domain was recently shown to bind the hyperphosphorylated C-terminal repeat domain of RNA polymerase II, confirming its role in protein-protein interactions.


:

Pssm-ID: 426471 [Multi-domain]  Cd Length: 50  Bit Score: 58.24  E-value: 4.14e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 169791011  456 ERVTHFRDMLLERGVSAFSTWEKELHKIVFDPRYL-LLNSEERKQIFEQF 504
Cdd:pfam01846   1 KAREAFKELLKEHKITPYSTWSEIKKKIENDPRYKaLLDGSEREELFEDY 50
FF pfam01846
FF domain; This domain has been predicted to be involved in protein-protein interaction. This ...
 523-571 1.14e-10

FF domain; This domain has been predicted to be involved in protein-protein interaction. This domain was recently shown to bind the hyperphosphorylated C-terminal repeat domain of RNA polymerase II, confirming its role in protein-protein interactions.


:

Pssm-ID: 426471 [Multi-domain]  Cd Length: 50  Bit Score: 56.70  E-value: 1.14e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 169791011  523 AKEEFKKLLEESKVSPRTTFKEFAEKHGRDQRFRLVQKRKDQEHFFNQF 571
Cdd:pfam01846   2 AREAFKELLKEHKITPYSTWSEIKKKIENDPRYKALLDGSEREELFEDY 50
PRP40 super family cl34905
Splicing factor [RNA processing and modification];
348-588 3.57e-07

Splicing factor [RNA processing and modification];


The actual alignment was detected with superfamily member COG5104:

Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 53.16  E-value: 3.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169791011 348 PWCVVWTGDDRVFFFNPTMQLSVWEKPvdlqnrgDLKRIIEDPPHKRKLEASATESSDGSSSDDGSEDQSVKTKRNRTES 427
Cdd:COG5104   57 PWKECRTADGKVYYYNSITRESRWKIP-------PERKKVEPIAEQKHDERSMIGGNGNDMAITDHETSEPKYLLGRLMS 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169791011 428 CEGpgpeDTHQVDKGPQtpppqilLPLEERVTHFRDMLLERGVSAFSTWEKELHKIVfDPRYLLLNSEE--RKQIFEQFV 505
Cdd:COG5104  130 QYG----ITSTKDAVYR-------LTKEEAEKEFITMLKENQVDSTWPIFRAIEELR-DPRYWMVDTDPlwRKDLFKKYF 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169791011 506 KTRIKEEYKERKSKLLLAKEEFKKLLE-ESKVSPRTTFKEFAEKHGRDQRFRLVQKRKDQEHFFNQFILILKKRDKENRL 584
Cdd:COG5104  198 ENQEKDQREEEENKQRKYINEFCKMLAgNSHIKYYTDWFTFKSIFSKHPYYSSVVNEKTKRQTFQKYKDKLGCYEKYVGK 277


                 ....
gi 169791011 585 RLRK 588
Cdd:COG5104  278 HMGG 281
 
Name Accession Description Interval E-value
FF pfam01846
FF domain; This domain has been predicted to be involved in protein-protein interaction. This ...
 456-504 4.14e-11

FF domain; This domain has been predicted to be involved in protein-protein interaction. This domain was recently shown to bind the hyperphosphorylated C-terminal repeat domain of RNA polymerase II, confirming its role in protein-protein interactions.


Pssm-ID: 426471 [Multi-domain]  Cd Length: 50  Bit Score: 58.24  E-value: 4.14e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 169791011  456 ERVTHFRDMLLERGVSAFSTWEKELHKIVFDPRYL-LLNSEERKQIFEQF 504
Cdd:pfam01846   1 KAREAFKELLKEHKITPYSTWSEIKKKIENDPRYKaLLDGSEREELFEDY 50
FF pfam01846
FF domain; This domain has been predicted to be involved in protein-protein interaction. This ...
 523-571 1.14e-10

FF domain; This domain has been predicted to be involved in protein-protein interaction. This domain was recently shown to bind the hyperphosphorylated C-terminal repeat domain of RNA polymerase II, confirming its role in protein-protein interactions.


Pssm-ID: 426471 [Multi-domain]  Cd Length: 50  Bit Score: 56.70  E-value: 1.14e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 169791011  523 AKEEFKKLLEESKVSPRTTFKEFAEKHGRDQRFRLVQKRKDQEHFFNQF 571
Cdd:pfam01846   2 AREAFKELLKEHKITPYSTWSEIKKKIENDPRYKALLDGSEREELFEDY 50
FF smart00441
Contains two conserved F residues; A novel motif that often accompanies WW domains. Often ...
 460-506 5.73e-08

Contains two conserved F residues; A novel motif that often accompanies WW domains. Often contains two conserved Phe (F) residues.


Pssm-ID: 128718 [Multi-domain]  Cd Length: 55  Bit Score: 49.49  E-value: 5.73e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 169791011   460 HFRDMLLERGVS-AFSTWEKELHKIVFDPRY-LLLNSEERKQIFEQFVK 506
Cdd:smart00441   6 AFKELLKEHEVItPDTTWSEARKKLKNDPRYkALLSESEREQLFEDHIE 54
PRP40 COG5104
Splicing factor [RNA processing and modification];
348-588 3.57e-07

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 53.16  E-value: 3.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169791011 348 PWCVVWTGDDRVFFFNPTMQLSVWEKPvdlqnrgDLKRIIEDPPHKRKLEASATESSDGSSSDDGSEDQSVKTKRNRTES 427
Cdd:COG5104   57 PWKECRTADGKVYYYNSITRESRWKIP-------PERKKVEPIAEQKHDERSMIGGNGNDMAITDHETSEPKYLLGRLMS 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169791011 428 CEGpgpeDTHQVDKGPQtpppqilLPLEERVTHFRDMLLERGVSAFSTWEKELHKIVfDPRYLLLNSEE--RKQIFEQFV 505
Cdd:COG5104  130 QYG----ITSTKDAVYR-------LTKEEAEKEFITMLKENQVDSTWPIFRAIEELR-DPRYWMVDTDPlwRKDLFKKYF 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169791011 506 KTRIKEEYKERKSKLLLAKEEFKKLLE-ESKVSPRTTFKEFAEKHGRDQRFRLVQKRKDQEHFFNQFILILKKRDKENRL 584
Cdd:COG5104  198 ENQEKDQREEEENKQRKYINEFCKMLAgNSHIKYYTDWFTFKSIFSKHPYYSSVVNEKTKRQTFQKYKDKLGCYEKYVGK 277


                 ....
gi 169791011 585 RLRK 588
Cdd:COG5104  278 HMGG 281
FF smart00441
Contains two conserved F residues; A novel motif that often accompanies WW domains. Often ...
 523-572 4.85e-05

Contains two conserved F residues; A novel motif that often accompanies WW domains. Often contains two conserved Phe (F) residues.


Pssm-ID: 128718 [Multi-domain]  Cd Length: 55  Bit Score: 41.02  E-value: 4.85e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 169791011   523 AKEEFKKLLEESKVS-PRTTFKEFAEKHGRDQRFRLVQKRKDQEHFFNQFI 572
Cdd:smart00441   3 AKEAFKELLKEHEVItPDTTWSEARKKLKNDPRYKALLSESEREQLFEDHI 53
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 347-376 4.18e-04

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 37.89  E-value: 4.18e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 169791011 347 SPWCVVWTGDDRVFFFNPTMQLSVWEKPVD 376
Cdd:cd00201    2 PGWEERWDPDGRVYYYNHNTKETQWEDPRE 31
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 347-374 6.18e-04

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 37.48  E-value: 6.18e-04
                          10        20
                  ....*....|....*....|....*...
gi 169791011  347 SPWCVVWTGDDRVFFFNPTMQLSVWEKP 374
Cdd:pfam00397   3 PGWEERWDPDGRVYYYNHETGETQWEKP 30
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 343-376 9.40e-04

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 36.81  E-value: 9.40e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 169791011   343 PVPgSPWCVVWTGDDRVFFFNPTMQLSVWEKPVD 376
Cdd:smart00456   1 PLP-PGWEERKDPDGRPYYYNHETKETQWEKPRE 33
 
Name Accession Description Interval E-value
FF pfam01846
FF domain; This domain has been predicted to be involved in protein-protein interaction. This ...
 456-504 4.14e-11

FF domain; This domain has been predicted to be involved in protein-protein interaction. This domain was recently shown to bind the hyperphosphorylated C-terminal repeat domain of RNA polymerase II, confirming its role in protein-protein interactions.


Pssm-ID: 426471 [Multi-domain]  Cd Length: 50  Bit Score: 58.24  E-value: 4.14e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 169791011  456 ERVTHFRDMLLERGVSAFSTWEKELHKIVFDPRYL-LLNSEERKQIFEQF 504
Cdd:pfam01846   1 KAREAFKELLKEHKITPYSTWSEIKKKIENDPRYKaLLDGSEREELFEDY 50
FF pfam01846
FF domain; This domain has been predicted to be involved in protein-protein interaction. This ...
 523-571 1.14e-10

FF domain; This domain has been predicted to be involved in protein-protein interaction. This domain was recently shown to bind the hyperphosphorylated C-terminal repeat domain of RNA polymerase II, confirming its role in protein-protein interactions.


Pssm-ID: 426471 [Multi-domain]  Cd Length: 50  Bit Score: 56.70  E-value: 1.14e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 169791011  523 AKEEFKKLLEESKVSPRTTFKEFAEKHGRDQRFRLVQKRKDQEHFFNQF 571
Cdd:pfam01846   2 AREAFKELLKEHKITPYSTWSEIKKKIENDPRYKALLDGSEREELFEDY 50
FF smart00441
Contains two conserved F residues; A novel motif that often accompanies WW domains. Often ...
 460-506 5.73e-08

Contains two conserved F residues; A novel motif that often accompanies WW domains. Often contains two conserved Phe (F) residues.


Pssm-ID: 128718 [Multi-domain]  Cd Length: 55  Bit Score: 49.49  E-value: 5.73e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 169791011   460 HFRDMLLERGVS-AFSTWEKELHKIVFDPRY-LLLNSEERKQIFEQFVK 506
Cdd:smart00441   6 AFKELLKEHEVItPDTTWSEARKKLKNDPRYkALLSESEREQLFEDHIE 54
PRP40 COG5104
Splicing factor [RNA processing and modification];
348-588 3.57e-07

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 53.16  E-value: 3.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169791011 348 PWCVVWTGDDRVFFFNPTMQLSVWEKPvdlqnrgDLKRIIEDPPHKRKLEASATESSDGSSSDDGSEDQSVKTKRNRTES 427
Cdd:COG5104   57 PWKECRTADGKVYYYNSITRESRWKIP-------PERKKVEPIAEQKHDERSMIGGNGNDMAITDHETSEPKYLLGRLMS 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169791011 428 CEGpgpeDTHQVDKGPQtpppqilLPLEERVTHFRDMLLERGVSAFSTWEKELHKIVfDPRYLLLNSEE--RKQIFEQFV 505
Cdd:COG5104  130 QYG----ITSTKDAVYR-------LTKEEAEKEFITMLKENQVDSTWPIFRAIEELR-DPRYWMVDTDPlwRKDLFKKYF 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169791011 506 KTRIKEEYKERKSKLLLAKEEFKKLLE-ESKVSPRTTFKEFAEKHGRDQRFRLVQKRKDQEHFFNQFILILKKRDKENRL 584
Cdd:COG5104  198 ENQEKDQREEEENKQRKYINEFCKMLAgNSHIKYYTDWFTFKSIFSKHPYYSSVVNEKTKRQTFQKYKDKLGCYEKYVGK 277


                 ....
gi 169791011 585 RLRK 588
Cdd:COG5104  278 HMGG 281
FF smart00441
Contains two conserved F residues; A novel motif that often accompanies WW domains. Often ...
 523-572 4.85e-05

Contains two conserved F residues; A novel motif that often accompanies WW domains. Often contains two conserved Phe (F) residues.


Pssm-ID: 128718 [Multi-domain]  Cd Length: 55  Bit Score: 41.02  E-value: 4.85e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 169791011   523 AKEEFKKLLEESKVS-PRTTFKEFAEKHGRDQRFRLVQKRKDQEHFFNQFI 572
Cdd:smart00441   3 AKEAFKELLKEHEVItPDTTWSEARKKLKNDPRYKALLSESEREQLFEDHI 53
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 347-376 4.18e-04

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 37.89  E-value: 4.18e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 169791011 347 SPWCVVWTGDDRVFFFNPTMQLSVWEKPVD 376
Cdd:cd00201    2 PGWEERWDPDGRVYYYNHNTKETQWEDPRE 31
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 347-374 6.18e-04

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 37.48  E-value: 6.18e-04
                          10        20
                  ....*....|....*....|....*...
gi 169791011  347 SPWCVVWTGDDRVFFFNPTMQLSVWEKP 374
Cdd:pfam00397   3 PGWEERWDPDGRVYYYNHETGETQWEKP 30
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 343-376 9.40e-04

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 36.81  E-value: 9.40e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 169791011   343 PVPgSPWCVVWTGDDRVFFFNPTMQLSVWEKPVD 376
Cdd:smart00456   1 PLP-PGWEERKDPDGRPYYYNHETKETQWEKPRE 33
OmpH smart00935
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 484-588 5.05e-03

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 214922 [Multi-domain]  Cd Length: 140  Bit Score: 37.56  E-value: 5.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169791011   484 VFDPRYLLLNSEERKQIFEQfvktrIKEEYKERKSKLLLAKEEFKKLLEE-SKVSPRTTFKEFAEKhgrdQRfRLVQKRK 562
Cdd:smart00935   3 VVDVQKILQESPAGKAAQKQ-----LEKEFKKRQAELEKLEKELQKLKEKlQKDAATLSEAAREKK----EK-ELQKKVQ 72

                           90       100
                   ....*....|....*....|....*.
gi 169791011   563 DQEHFFNQFILILKKRDKENRLRLRK 588
Cdd:smart00935  73 EFQRKQQKLQQDLQKRQQEELQKILD 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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