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Conserved domains on  [gi|222352166|ref|NP_963845|]
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protein kinase C-binding protein NELL1 isoform 2 precursor [Homo sapiens]

Protein Classification

calcium-binding EGF-like domain-containing protein( domain architecture ID 11259390)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 29-213 1.12e-59

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


:

Pssm-ID: 214560  Cd Length: 184  Bit Score: 199.89  E-value: 1.12e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352166    29 QMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQDIereiHAAPHVSEKLIQlFRNKSEFTILATVQQKPSTSGVILSI-R 107
Cdd:smart00210   1 GQDLLQVFDLPSLSFAIRQVVGPEPGSPAYRLGDP----ALVPQPTRDLFP-SGLPEDFSLLTTFRQTPKSRGVLFAIyD 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352166   108 ELEHSYFELESSGLRDEIRYHY-IHNGKPRTEALP-YRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPD--TNLP 183
Cdd:smart00210  76 AQNVRQFGLEVDGRANTLLLRYqGVDGKQHTVSFRnLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRPGqpPIDT 155

                          170       180       190
                   ....*....|....*....|....*....|
gi 222352166   184 PGINLWLGQRNQkHGLFKGIIQDGKIIFMP 213
Cdd:smart00210 156 DGIEVRGAQAAD-RKPFQGDLQQLKIVCDP 184
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 480-515 2.73e-09

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 52.99  E-value: 2.73e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 222352166  480 CGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTIC 515
Cdd:pfam12947   1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 273-331 7.93e-08

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


:

Pssm-ID: 278520  Cd Length: 57  Bit Score: 49.35  E-value: 7.93e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 222352166  273 CQVSGLLYRDQDSWVDgDHCRNCTCKSGAVECRRMSCPPLNCsPDSLPVHIAGQCCKVC 331
Cdd:pfam00093   1 CVQNGVVYENGETWKP-DLCTICTCDDGKVLCDKIICPPLDC-PNPRLEIPPGECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 654-702 7.51e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 43.95  E-value: 7.51e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 222352166  654 KLYRSGDNWT-HSCQQCRCLEGEVDCWPLTCPNLSCE--YTAILEGECCPRC 702
Cdd:pfam00093   6 VVYENGETWKpDLCTICTCDDGKVLCDKIICPPLDCPnpRLEIPPGECCPVC 57
EGF_CA pfam07645
Calcium-binding EGF domain;
549-580 2.59e-05

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.45  E-value: 2.59e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 222352166  549 DIDECALRTHTCWNDSACINLAGGFDCLCPSG 580
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
434-466 1.41e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 1.41e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 222352166   434 DIDECAAKmHYCHANTVCVNLPGLYRCDCVPGY 466
Cdd:smart00179   1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 587-639 8.70e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 35.09  E-value: 8.70e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 222352166  587 CPHEGGLKHNGQVWtlKEDRCSVCSCKDGKIFCRRTAC---DCQNPSADLF---CCPEC 639
Cdd:pfam00093   1 CVQNGVVYENGETW--KPDLCTICTCDDGKVLCDKIICpplDCPNPRLEIPpgeCCPVC 57
 
Name Accession Description Interval E-value
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 29-213 1.12e-59

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 199.89  E-value: 1.12e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352166    29 QMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQDIereiHAAPHVSEKLIQlFRNKSEFTILATVQQKPSTSGVILSI-R 107
Cdd:smart00210   1 GQDLLQVFDLPSLSFAIRQVVGPEPGSPAYRLGDP----ALVPQPTRDLFP-SGLPEDFSLLTTFRQTPKSRGVLFAIyD 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352166   108 ELEHSYFELESSGLRDEIRYHY-IHNGKPRTEALP-YRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPD--TNLP 183
Cdd:smart00210  76 AQNVRQFGLEVDGRANTLLLRYqGVDGKQHTVSFRnLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRPGqpPIDT 155

                          170       180       190
                   ....*....|....*....|....*....|
gi 222352166   184 PGINLWLGQRNQkHGLFKGIIQDGKIIFMP 213
Cdd:smart00210 156 DGIEVRGAQAAD-RKPFQGDLQQLKIVCDP 184
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 98-206 2.40e-09

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 56.66  E-value: 2.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352166  98 STSGVILSI-RELEHSYFELEssgLRD-EIRYHYiHNGKPRTEA-LPYRMADGQWHKVALSVSASHLLLHVDCNRIYERV 174
Cdd:cd00110   32 SPNGLLLYAgSQNGGDFLALE---LEDgRLVLRY-DLGSGSLVLsSKTPLNDGQWHSVSVERNGRSVTLSVDGERVVESG 107

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 222352166 175 IDPPDTNLPPGINLWLG----QRNQKHGL----FKGIIQD 206
Cdd:cd00110  108 SPGGSALLNLDGPLYLGglpeDLKSPGLPvspgFVGCIRD 147
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 480-515 2.73e-09

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 52.99  E-value: 2.73e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 222352166  480 CGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTIC 515
Cdd:pfam12947   1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 273-331 7.93e-08

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 49.35  E-value: 7.93e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 222352166  273 CQVSGLLYRDQDSWVDgDHCRNCTCKSGAVECRRMSCPPLNCsPDSLPVHIAGQCCKVC 331
Cdd:pfam00093   1 CVQNGVVYENGETWKP-DLCTICTCDDGKVLCDKIICPPLDC-PNPRLEIPPGECCPVC 57
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 98-191 6.25e-07

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 48.96  E-value: 6.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352166   98 STSGVILSIRELEHSYFELEssgLRD-EIRYHY-IHNGKPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVI 175
Cdd:pfam02210   5 QPNGLLLYAGGGGSDFLALE---LVNgRLVLRYdLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSLP 81

                          90
                  ....*....|....*.
gi 222352166  176 DPPDTNLPPGINLWLG 191
Cdd:pfam02210  82 PGESLLLNLNGPLYLG 97
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 654-702 7.51e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 43.95  E-value: 7.51e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 222352166  654 KLYRSGDNWT-HSCQQCRCLEGEVDCWPLTCPNLSCE--YTAILEGECCPRC 702
Cdd:pfam00093   6 VVYENGETWKpDLCTICTCDDGKVLCDKIICPPLDCPnpRLEIPPGECCPVC 57
EGF_CA pfam07645
Calcium-binding EGF domain;
549-580 2.59e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.45  E-value: 2.59e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 222352166  549 DIDECALRTHTCWNDSACINLAGGFDCLCPSG 580
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
VWC smart00214
von Willebrand factor (vWF) type C domain;
656-702 9.45e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.96  E-value: 9.45e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 222352166   656 YRSGDNWT-HSCQQCRCLEGE-VDCWPLTCP-NLSCE--YTAILEGECCPRC 702
Cdd:smart00214   8 YNDGETWKpDPCQICTCLDGTtVLCDPVECPpPPDCPnpERVKPPGECCPRC 59
EGF_CA smart00179
Calcium-binding EGF-like domain;
434-466 1.41e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 1.41e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 222352166   434 DIDECAAKmHYCHANTVCVNLPGLYRCDCVPGY 466
Cdd:smart00179   1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA pfam07645
Calcium-binding EGF domain;
434-465 1.47e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.53  E-value: 1.47e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 222352166  434 DIDECAAKMHYCHANTVCVNLPGLYRCDCVPG 465
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
549-587 3.53e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 3.53e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 222352166   549 DIDECALRtHTCWNDSACINLAGGFDCLCPSGPSCSGDC 587
Cdd:smart00179   1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYTDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 434-467 5.74e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 5.74e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 222352166 434 DIDECAAkMHYCHANTVCVNLPGLYRCDCVPGYI 467
Cdd:cd00054    1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPGYT 33
VWC smart00214
von Willebrand factor (vWF) type C domain;
273-331 2.10e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 37.11  E-value: 2.10e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352166   273 CQVSGLLYRDQDSWVDgDHCRNCTCKSGA-VECRRMSCPPLNCSPDSLPVHIAGQCCKVC 331
Cdd:smart00214   1 CVHNGRVYNDGETWKP-DPCQICTCLDGTtVLCDPVECPPPPDCPNPERVKPPGECCPRC 59
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 549-580 2.56e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 2.56e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 222352166 549 DIDECALRtHTCWNDSACINLAGGFDCLCPSG 580
Cdd:cd00054    1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 478-510 2.80e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 2.80e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 222352166 478 DECGSGqHNCDENAICTNTVQGHSCTCKPGYVG 510
Cdd:cd00054    3 DECASG-NPCQNGGTCVNTVGSYRCSCPPGYTG 34
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 587-639 8.70e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 35.09  E-value: 8.70e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 222352166  587 CPHEGGLKHNGQVWtlKEDRCSVCSCKDGKIFCRRTAC---DCQNPSADLF---CCPEC 639
Cdd:pfam00093   1 CVQNGVVYENGETW--KPDLCTICTCDDGKVLCDKIICpplDCPNPRLEIPpgeCCPVC 57
 
Name Accession Description Interval E-value
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 29-213 1.12e-59

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 199.89  E-value: 1.12e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352166    29 QMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQDIereiHAAPHVSEKLIQlFRNKSEFTILATVQQKPSTSGVILSI-R 107
Cdd:smart00210   1 GQDLLQVFDLPSLSFAIRQVVGPEPGSPAYRLGDP----ALVPQPTRDLFP-SGLPEDFSLLTTFRQTPKSRGVLFAIyD 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352166   108 ELEHSYFELESSGLRDEIRYHY-IHNGKPRTEALP-YRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPD--TNLP 183
Cdd:smart00210  76 AQNVRQFGLEVDGRANTLLLRYqGVDGKQHTVSFRnLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRPGqpPIDT 155

                          170       180       190
                   ....*....|....*....|....*....|
gi 222352166   184 PGINLWLGQRNQkHGLFKGIIQDGKIIFMP 213
Cdd:smart00210 156 DGIEVRGAQAAD-RKPFQGDLQQLKIVCDP 184
LamG smart00282
Laminin G domain;
98-206 4.81e-14

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 69.68  E-value: 4.81e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352166    98 STSGVILSIRELEHS-YFELESSGLRDEIRYHYiHNGKPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVID 176
Cdd:smart00282  10 SPNGLLLYAGSKGGGdYLALELRDGRLVLRYDL-GSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGGNRVSGESP 88

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 222352166   177 PPDTNLPPGINLWLG----QRNQKHGL----FKGIIQD 206
Cdd:smart00282  89 GGLTILNLDGPLYLGglpeDLKLPPLPvtpgFRGCIRN 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 98-206 2.40e-09

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 56.66  E-value: 2.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352166  98 STSGVILSI-RELEHSYFELEssgLRD-EIRYHYiHNGKPRTEA-LPYRMADGQWHKVALSVSASHLLLHVDCNRIYERV 174
Cdd:cd00110   32 SPNGLLLYAgSQNGGDFLALE---LEDgRLVLRY-DLGSGSLVLsSKTPLNDGQWHSVSVERNGRSVTLSVDGERVVESG 107

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 222352166 175 IDPPDTNLPPGINLWLG----QRNQKHGL----FKGIIQD 206
Cdd:cd00110  108 SPGGSALLNLDGPLYLGglpeDLKSPGLPvspgFVGCIRD 147
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 480-515 2.73e-09

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 52.99  E-value: 2.73e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 222352166  480 CGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTIC 515
Cdd:pfam12947   1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 273-331 7.93e-08

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 49.35  E-value: 7.93e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 222352166  273 CQVSGLLYRDQDSWVDgDHCRNCTCKSGAVECRRMSCPPLNCsPDSLPVHIAGQCCKVC 331
Cdd:pfam00093   1 CVQNGVVYENGETWKP-DLCTICTCDDGKVLCDKIICPPLDC-PNPRLEIPPGECCPVC 57
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 98-191 6.25e-07

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 48.96  E-value: 6.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352166   98 STSGVILSIRELEHSYFELEssgLRD-EIRYHY-IHNGKPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVI 175
Cdd:pfam02210   5 QPNGLLLYAGGGGSDFLALE---LVNgRLVLRYdLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSLP 81

                          90
                  ....*....|....*.
gi 222352166  176 DPPDTNLPPGINLWLG 191
Cdd:pfam02210  82 PGESLLLNLNGPLYLG 97
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 654-702 7.51e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 43.95  E-value: 7.51e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 222352166  654 KLYRSGDNWT-HSCQQCRCLEGEVDCWPLTCPNLSCE--YTAILEGECCPRC 702
Cdd:pfam00093   6 VVYENGETWKpDLCTICTCDDGKVLCDKIICPPLDCPnpRLEIPPGECCPVC 57
EGF_CA pfam07645
Calcium-binding EGF domain;
478-507 7.68e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.99  E-value: 7.68e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 222352166  478 DECGSGQHNCDENAICTNTVQGHSCTCKPG 507
Cdd:pfam07645   3 DECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
549-580 2.59e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.45  E-value: 2.59e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 222352166  549 DIDECALRTHTCWNDSACINLAGGFDCLCPSG 580
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
Laminin_G_1 pfam00054
Laminin G domain;
98-213 8.55e-05

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 43.07  E-value: 8.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352166   98 STSGVILSI-RELEHSYFELEssgLRD-EIRYHY-IHNGKPRTEALPyRMADGQWHKVALSVSASHLLLHVD-CNRIYER 173
Cdd:pfam00054   5 EPSGLLLYNgTQTERDFLALE---LRDgRLEVSYdLGSGAAVVRSGD-KLNDGKWHSVELERNGRSGTLSVDgEARPTGE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 222352166  174 VIDPPDTNLPPGINLWLG-----------QRNQKHglFKGIIQDGKIIFMP 213
Cdd:pfam00054  81 SPLGATTDLDVDGPLYVGglpslgvkkrrLAISPS--FDGCIRDVIVNGKP 129
VWC smart00214
von Willebrand factor (vWF) type C domain;
656-702 9.45e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.96  E-value: 9.45e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 222352166   656 YRSGDNWT-HSCQQCRCLEGE-VDCWPLTCP-NLSCE--YTAILEGECCPRC 702
Cdd:smart00214   8 YNDGETWKpDPCQICTCLDGTtVLCDPVECPpPPDCPnpERVKPPGECCPRC 59
EGF_CA smart00179
Calcium-binding EGF-like domain;
434-466 1.41e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 1.41e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 222352166   434 DIDECAAKmHYCHANTVCVNLPGLYRCDCVPGY 466
Cdd:smart00179   1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA pfam07645
Calcium-binding EGF domain;
434-465 1.47e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.53  E-value: 1.47e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 222352166  434 DIDECAAKMHYCHANTVCVNLPGLYRCDCVPG 465
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
549-587 3.53e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 3.53e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 222352166   549 DIDECALRtHTCWNDSACINLAGGFDCLCPSGPSCSGDC 587
Cdd:smart00179   1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYTDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 434-467 5.74e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 5.74e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 222352166 434 DIDECAAkMHYCHANTVCVNLPGLYRCDCVPGYI 467
Cdd:cd00054    1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPGYT 33
VWC smart00214
von Willebrand factor (vWF) type C domain;
273-331 2.10e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 37.11  E-value: 2.10e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352166   273 CQVSGLLYRDQDSWVDgDHCRNCTCKSGA-VECRRMSCPPLNCSPDSLPVHIAGQCCKVC 331
Cdd:smart00214   1 CVHNGRVYNDGETWKP-DPCQICTCLDGTtVLCDPVECPPPPDCPNPERVKPPGECCPRC 59
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 549-580 2.56e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 2.56e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 222352166 549 DIDECALRtHTCWNDSACINLAGGFDCLCPSG 580
Cdd:cd00054    1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 478-510 2.80e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 2.80e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 222352166 478 DECGSGqHNCDENAICTNTVQGHSCTCKPGYVG 510
Cdd:cd00054    3 DECASG-NPCQNGGTCVNTVGSYRCSCPPGYTG 34
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 587-639 8.70e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 35.09  E-value: 8.70e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 222352166  587 CPHEGGLKHNGQVWtlKEDRCSVCSCKDGKIFCRRTAC---DCQNPSADLF---CCPEC 639
Cdd:pfam00093   1 CVQNGVVYENGETW--KPDLCTICTCDDGKVLCDKIICpplDCPNPRLEIPpgeCCPVC 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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