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Conserved domains on  [gi|528474643|ref|XP_005164182|]
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WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [Danio rerio]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
121-280 4.10e-12

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.24  E-value: 4.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528474643 121 IHNIRDMKVLHTIRETPPNPSglcALSISNDNCYLAYpGSATiGEVQVFDTVNLRAANMIPAHDSPLAALAFDASGTKLA 200
Cdd:COG2319  230 LWDLATGKLLRTLTGHSGSVR---SVAFSPDGRLLAS-GSAD-GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLA 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528474643 201 TASEKGTViRVFSIPEGQKLFEFRRGVKRcvsICSLAFSMEGLYLSASSNTETVHIFKLETqrekpQEEPTTWTGYFGKV 280
Cdd:COG2319  305 SGSDDGTV-RLWDLATGKLLRTLTGHTGA---VRSVAFSPDGKTLASGSDDGTVRLWDLAT-----GELLRTLTGHTGAV 375
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
121-280 4.10e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.24  E-value: 4.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528474643 121 IHNIRDMKVLHTIRETPPNPSglcALSISNDNCYLAYpGSATiGEVQVFDTVNLRAANMIPAHDSPLAALAFDASGTKLA 200
Cdd:COG2319  230 LWDLATGKLLRTLTGHSGSVR---SVAFSPDGRLLAS-GSAD-GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLA 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528474643 201 TASEKGTViRVFSIPEGQKLFEFRRGVKRcvsICSLAFSMEGLYLSASSNTETVHIFKLETqrekpQEEPTTWTGYFGKV 280
Cdd:COG2319  305 SGSDDGTV-RLWDLATGKLLRTLTGHTGA---VRSVAFSPDGKTLASGSDDGTVRLWDLAT-----GELLRTLTGHTGAV 375
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 121-265 4.38e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.26  E-value: 4.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528474643 121 IHNIRDMKVLHTIREtppNPSGLCALSISNDNCYLAypGSATIGEVQVFDTVNLRAANMIPAHDSPLAALAFDASGTKLA 200
Cdd:cd00200  119 VWDVETGKCLTTLRG---HTDWVNSVAFSPDGTFVA--SSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLL 193

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528474643 201 TASEKGTvIRVFSIPEGQKLFEFRRgvkRCVSICSLAFSMEGLYLSASSNTETVHIFKLETQREK 265
Cdd:cd00200  194 SSSSDGT-IKLWDLSTGKCLGTLRG---HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECV 254
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
121-280 4.10e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.24  E-value: 4.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528474643 121 IHNIRDMKVLHTIRETPPNPSglcALSISNDNCYLAYpGSATiGEVQVFDTVNLRAANMIPAHDSPLAALAFDASGTKLA 200
Cdd:COG2319  230 LWDLATGKLLRTLTGHSGSVR---SVAFSPDGRLLAS-GSAD-GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLA 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528474643 201 TASEKGTViRVFSIPEGQKLFEFRRGVKRcvsICSLAFSMEGLYLSASSNTETVHIFKLETqrekpQEEPTTWTGYFGKV 280
Cdd:COG2319  305 SGSDDGTV-RLWDLATGKLLRTLTGHTGA---VRSVAFSPDGKTLASGSDDGTVRLWDLAT-----GELLRTLTGHTGAV 375
WD40 COG2319
WD40 repeat [General function prediction only];
133-345 9.34e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.01  E-value: 9.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528474643 133 IRETPPNPSGLCALSISNDNCYLAYPGSAtiGEVQVFDTVNLRAANMIPAHDSPLAALAFDASGTKLATASEKGTViRVF 212
Cdd:COG2319   71 LATLLGHTAAVLSVAFSPDGRLLASASAD--GTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV-RLW 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528474643 213 SIPEGQKLFEFrRGVKRCVSicSLAFSMEGLYLSASSNTETVHIFKLETQRekpqeEPTTWTGYFGKVLmaSTTYLPahv 292
Cdd:COG2319  148 DLATGKLLRTL-TGHSGAVT--SVAFSPDGKLLASGSDDGTVRLWDLATGK-----LLRTLTGHTGAVR--SVAFSP--- 214

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528474643 293 temftQGRAFA------TVRL----------PFSGHKN-ICALAIIQKIPRLLVAAADGYLYLYNLDPQE 345
Cdd:COG2319  215 -----DGKLLAsgsadgTVRLwdlatgkllrTLTGHSGsVRSVAFSPDGRLLASGSADGTVRLWDLATGE 279
WD40 COG2319
WD40 repeat [General function prediction only];
118-261 2.70e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.85  E-value: 2.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528474643 118 SLYIHNIRDMKVLHTIRetpPNPSGLCALSISNDNCYLAYpGSATiGEVQVFDTVNLRAANMIPAHDSPLAALAFDASGT 197
Cdd:COG2319  269 TVRLWDLATGELLRTLT---GHSGGVNSVAFSPDGKLLAS-GSDD-GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGK 343

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528474643 198 KLATASEKGTViRVFSIPEGQKLFEFRRGVKRcvsICSLAFSMEGLYLSASSNTETVHIFKLET 261
Cdd:COG2319  344 TLASGSDDGTV-RLWDLATGELLRTLTGHTGA---VTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 121-265 4.38e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.26  E-value: 4.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528474643 121 IHNIRDMKVLHTIREtppNPSGLCALSISNDNCYLAypGSATIGEVQVFDTVNLRAANMIPAHDSPLAALAFDASGTKLA 200
Cdd:cd00200  119 VWDVETGKCLTTLRG---HTDWVNSVAFSPDGTFVA--SSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLL 193

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528474643 201 TASEKGTvIRVFSIPEGQKLFEFRRgvkRCVSICSLAFSMEGLYLSASSNTETVHIFKLETQREK 265
Cdd:cd00200  194 SSSSDGT-IKLWDLSTGKCLGTLRG---HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECV 254
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 145-345 1.21e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.72  E-value: 1.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528474643 145 ALSISNDNCYLAypGSATIGEVQVFDTVNLRAANMIPAHDSPLAALAFDASGTKLATASEKGTvIRVFSIPEGQKLFEFr 224
Cdd:cd00200   56 DVAASADGTYLA--SGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKT-IKVWDVETGKCLTTL- 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528474643 225 RGVKRcvSICSLAFSMEGLYLSASSNTETVHIFKLETQREKpqeepTTWTGYFGKVLmaSTTYLPahvtemftQGRAFA- 303
Cdd:cd00200  132 RGHTD--WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCV-----ATLTGHTGEVN--SVAFSP--------DGEKLLs 194

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 528474643 304 -----TVRL----------PFSGHKN-ICALAIIQKiPRLLVAAA-DGYLYLYNLDPQE 345
Cdd:cd00200  195 sssdgTIKLwdlstgkclgTLRGHENgVNSVAFSPD-GYLLASGSeDGTIRVWDLRTGE 252
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 180-356 3.83e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.18  E-value: 3.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528474643 180 IPAHDSPLAALAFDASGTKLATASEKGTvIRVFSIPEGQKLFEFR---RGVKRCVSICSlafsmeGLYLSASSNTETVHI 256
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGT-IKVWDLETGELLRTLKghtGPVRDVAASAD------GTYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528474643 257 FKLETqrekpQEEPTTWTGYFGKVLmaSTTYLPAHvtEMFTQGRAFATVRL----------PFSGHKN-ICALAIIQKIP 325
Cdd:cd00200   78 WDLET-----GECVRTLTGHTSYVS--SVAFSPDG--RILSSSSRDKTIKVwdvetgkcltTLRGHTDwVNSVAFSPDGT 148

                        170       180       190
                 ....*....|....*....|....*....|.
gi 528474643 326 RLLVAAADGYLYLYNLDpqEGGECTLMKQHK 356
Cdd:cd00200  149 FVASSSQDGTIKLWDLR--TGKCVATLTGHT 177
WD40 COG2319
WD40 repeat [General function prediction only];
160-345 1.34e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.29  E-value: 1.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528474643 160 SATIGEVQVFDTVNLRAANMIPAHDSPLAALAFDASGTKLATASEKGTViRVFSIPEGQKLFEFRRGVKrcvSICSLAFS 239
Cdd:COG2319   54 GAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTV-RLWDLATGLLLRTLTGHTG---AVRSVAFS 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528474643 240 MEGLYLSASSNTETVHIFKLETQRekpqeEPTTWTGYFGKVLmaSTTYLPahvtemftQGRAFA------TVRL------ 307
Cdd:COG2319  130 PDGKTLASGSADGTVRLWDLATGK-----LLRTLTGHSGAVT--SVAFSP--------DGKLLAsgsddgTVRLwdlatg 194

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 528474643 308 ----PFSGHKN-ICALAIIQKIPRLLVAAADGYLYLYNLDPQE 345
Cdd:COG2319  195 kllrTLTGHTGaVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
102-217 3.77e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 44.69  E-value: 3.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528474643 102 LAVKLNRQRLIVCLEES--LYIHNIRDMKVLHTIrETPPNPSGLcALSISNDNCYLAYPGSATIGE-VQVFDTVNLRAAN 178
Cdd:COG3391  115 LAVDPDGGRLYVADSGNgrVSVIDTATGKVVATI-PVGAGPHGI-AVDPDGKRLYVANSGSNTVSViVSVIDTATGKVVA 192

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 528474643 179 MIPAHDSPLaALAFDASGTKL-------ATASEKGTVIRVFSIPEG 217
Cdd:COG3391  193 TIPVGGGPV-GVAVSPDGRRLyvanrgsNTSNGGSNTVSVIDLATL 237
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 98-213 4.04e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.02  E-value: 4.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528474643  98 SNTILAVKL--NRQRLIVC-LEESLYIHNIRDMKVLHTIREtppNPSGLCALSISNDNCYLAypGSATIGEVQVFDTVNL 174
Cdd:cd00200  177 TGEVNSVAFspDGEKLLSSsSDGTIKLWDLSTGKCLGTLRG---HENGVNSVAFSPDGYLLA--SGSEDGTIRVWDLRTG 251

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 528474643 175 RAANMIPAHDSPLAALAFDASGTKLATASEKGTvIRVFS 213
Cdd:cd00200  252 ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGT-IRIWD 289
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
164-257 8.96e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.83  E-value: 8.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528474643 164 GEVQVFDTVNLRAANMIPAHDSPlAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGvkrcVSICSLAFSMEGL 243
Cdd:COG3391   90 GRVSVIDLATGKVVATIPVGGGP-RGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVG----AGPHGIAVDPDGK 164

                         90
                 ....*....|....*
gi 528474643 244 YL-SASSNTETVHIF 257
Cdd:COG3391  165 RLyVANSGSNTVSVI 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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