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Conserved domains on  [gi|530398666|ref|XP_005253751|]
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COP9 signalosome complex subunit 7a isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CSN7a_helixI pfam18392
COP9 signalosome complex subunit 7a helix I domain; This is The C-terminal helix I domain ...
 166-215 1.21e-21

COP9 signalosome complex subunit 7a helix I domain; This is The C-terminal helix I domain found in COP9 signalosome complex subunit 7a. The helix from CSN7 (helix I) contacts CSN6 helices I and II at the base of the bundle, nearest the PCI ring.


:

Pssm-ID: 465740  Cd Length: 50  Bit Score: 85.04  E-value: 1.21e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 530398666  166 DLSAIARTLQEWCVGCEVVLSGIEEQVSRANQHKEQQLGLKQQIESEVAN 215
Cdd:pfam18392   1 DIGVIINTLQEWCDSCEAVLSCIETQVNRANAEKNKHIKHKEKIEQEIAN 50
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
 87-177 1.68e-12

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


:

Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 61.87  E-value: 1.68e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530398666    87 PLTEAQKNKLRHLSVVTLAAKVKCIPYAVLLEALALRNVrQLEDLVIEAVYADVLRGSLDQRNQRLEVDYSIGRDIQRQD 166
Cdd:smart00088   1 QLVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVP-EVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPRRSEPLA 79

                           90
                   ....*....|.
gi 530398666   167 lsAIARTLQEW 177
Cdd:smart00088  80 --QFAETLKKL 88
 
Name Accession Description Interval E-value
CSN7a_helixI pfam18392
COP9 signalosome complex subunit 7a helix I domain; This is The C-terminal helix I domain ...
 166-215 1.21e-21

COP9 signalosome complex subunit 7a helix I domain; This is The C-terminal helix I domain found in COP9 signalosome complex subunit 7a. The helix from CSN7 (helix I) contacts CSN6 helices I and II at the base of the bundle, nearest the PCI ring.


Pssm-ID: 465740  Cd Length: 50  Bit Score: 85.04  E-value: 1.21e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 530398666  166 DLSAIARTLQEWCVGCEVVLSGIEEQVSRANQHKEQQLGLKQQIESEVAN 215
Cdd:pfam18392   1 DIGVIINTLQEWCDSCEAVLSCIETQVNRANAEKNKHIKHKEKIEQEIAN 50
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
 87-177 1.68e-12

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 61.87  E-value: 1.68e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530398666    87 PLTEAQKNKLRHLSVVTLAAKVKCIPYAVLLEALALRNVrQLEDLVIEAVYADVLRGSLDQRNQRLEVDYSIGRDIQRQD 166
Cdd:smart00088   1 QLVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVP-EVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPRRSEPLA 79

                           90
                   ....*....|.
gi 530398666   167 lsAIARTLQEW 177
Cdd:smart00088  80 --QFAETLKKL 88
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
 64-154 5.92e-06

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 44.13  E-value: 5.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530398666   64 FRLLTVFAYGTYADYLAEAR----------NLPPLTEAQKNKLRHLSVVTLAAKVKCIPYAVLLEALALrNVRQLEDLVI 133
Cdd:pfam01399   4 RDLLRAFYSGDLSEFEEILAdykeelllddGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGL-SVDEVEKILA 82

                          90       100
                  ....*....|....*....|.
gi 530398666  134 EAVYADVLRGSLDQRNQRLEV 154
Cdd:pfam01399  83 KLIRDGRIRAKIDQVNGIVVF 103
 
Name Accession Description Interval E-value
CSN7a_helixI pfam18392
COP9 signalosome complex subunit 7a helix I domain; This is The C-terminal helix I domain ...
 166-215 1.21e-21

COP9 signalosome complex subunit 7a helix I domain; This is The C-terminal helix I domain found in COP9 signalosome complex subunit 7a. The helix from CSN7 (helix I) contacts CSN6 helices I and II at the base of the bundle, nearest the PCI ring.


Pssm-ID: 465740  Cd Length: 50  Bit Score: 85.04  E-value: 1.21e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 530398666  166 DLSAIARTLQEWCVGCEVVLSGIEEQVSRANQHKEQQLGLKQQIESEVAN 215
Cdd:pfam18392   1 DIGVIINTLQEWCDSCEAVLSCIETQVNRANAEKNKHIKHKEKIEQEIAN 50
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
 87-177 1.68e-12

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 61.87  E-value: 1.68e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530398666    87 PLTEAQKNKLRHLSVVTLAAKVKCIPYAVLLEALALRNVrQLEDLVIEAVYADVLRGSLDQRNQRLEVDYSIGRDIQRQD 166
Cdd:smart00088   1 QLVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVP-EVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPRRSEPLA 79

                           90
                   ....*....|.
gi 530398666   167 lsAIARTLQEW 177
Cdd:smart00088  80 --QFAETLKKL 88
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
 64-154 5.92e-06

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 44.13  E-value: 5.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530398666   64 FRLLTVFAYGTYADYLAEAR----------NLPPLTEAQKNKLRHLSVVTLAAKVKCIPYAVLLEALALrNVRQLEDLVI 133
Cdd:pfam01399   4 RDLLRAFYSGDLSEFEEILAdykeelllddGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGL-SVDEVEKILA 82

                          90       100
                  ....*....|....*....|.
gi 530398666  134 EAVYADVLRGSLDQRNQRLEV 154
Cdd:pfam01399  83 KLIRDGRIRAKIDQVNGIVVF 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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