|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00108 |
PTZ00108 |
DNA topoisomerase 2-like protein; Provisional |
13-1485 |
0e+00 |
|
DNA topoisomerase 2-like protein; Provisional
Pssm-ID: 240271 [Multi-domain] Cd Length: 1388 Bit Score: 1699.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 13 KKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVG-INYREVTFVPGLYKIFDEILVNAADNKQRDP--- 88
Cdd:PTZ00108 1 KKNKTVEERYQKKTQIEHILLRPDTYIGSIETQTEDMWVYDEEKNrMVYKTITYVPGLYKIFDEILVNAADNKARDKggh 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 89 KMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE 168
Cdd:PTZ00108 81 RMTYIKVTIDEENGEISVYNDGEGIPVQIHKEHKIYVPEMIFGHLLTSSNYDDTEKRVTGGRNGFGAKLTNIFSTKFTVE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 169 TASREYKKMFKQTWMDNMGRAGEMELKPFNG-EDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNG 247
Cdd:PTZ00108 161 CVDSKSGKKFKMTWTDNMSKKSEPRITSYDGkKDYTKVTFYPDYAKFGMTEFDDDMLRLLKKRVYDLAGCFGKLKVYLNG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 248 NKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVD 327
Cdd:PTZ00108 241 ERIAIKSFKDYVDLYLPDGEEGKKPPYPFVYTSVNGRWEVVVSLSDGQFQQVSFVNSICTTKGGTHVNYILDQLISKLQE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 328 VVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKA 407
Cdd:PTZ00108 321 KAKKKKKKGKEIKPNQIKNHLWVFVNCLIVNPSFDSQTKETLTTKPSKFGSTCELSEKLIKYVLKSPILENIVEWAQAKL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 408 QVQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHK 487
Cdd:PTZ00108 401 AAELNKKMKAGKKSRILGIPKLDDANDAGGKNSEECTLILTEGDSAKALALAGLSVVGRDYYGVFPLRGKLLNVRDASLK 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 488 QIMENAEINNIIKIVGLQYKKNYEDedsLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHR-FLEEFITPIV 566
Cdd:PTZ00108 481 QLMNNKEIQNLFKILGLDIGKKYED---PKGLRYGSLMIMTDQDHDGSHIKGLLINMIHHFWPSLLKNPgFLKEFITPIV 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 567 KVSK-NKQEMAFYSLPEFEEWKSSTPNhKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQ 645
Cdd:PTZ00108 558 KATKkGNQVISFFTIPDFEKWKQTVGL-KGWKIKYYKGLGTSTDKEGKEYFSNIDKHRIRFVYVDDSDDDSIDLAFSKKR 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 646 IDDRKEWLTNFME----DRRQRKllglpedylygqtttyLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTC 721
Cdd:PTZ00108 637 VEDRKEWITNYKGgtyvDHSKKK----------------LTYSDFVNKELILFSIADNERSIPSLVDGLKPGQRKILFAC 700
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 722 FKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSL 801
Cdd:PTZ00108 701 FKRNLKNEIKVAQLSGYVSEHSAYHHGEQSLQQTIVGMAQNFVGSNNINLLYPCGQFGSRLQGGKDHAAARYIFTKLSKI 780
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 802 ARLLFPPKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYK 881
Cdd:PTZ00108 781 TRYIFPEEDDPILDYLEDDGQSVEPFYYVPIIPMVLVNGAEGIGTGFSTSIPNYNPLDIIDNLRRRLNGEEVRPLVPWYR 860
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 882 NFKGTIEELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEqVLEpmlNGTEKTPPLITDYREYHTDTTVKFVVKMT 961
Cdd:PTZ00108 861 GFKGTIERNPKGKFISKGIYEKVPDGTVEITELPIGKWTEDYKE-FLE---SETLKEKDVIVDYRDYSTANTVHFTVKLN 936
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 962 EEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQAR 1041
Cdd:PTZ00108 937 DGVLEQWEEEGIEKVFKLKSTISTTNMVLFDENGKIKKYSDALDILKEFYLVRLDLYKKRKEYLLGKLERELARLSNKVR 1016
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1042 FILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPL 1121
Cdd:PTZ00108 1017 FIKHVINGELVITNAKKKDLVKELKKLGYVRFKDIIKKKSEKITAEEEEGAEEDDEADDEDDEEELGAAVSYDYLLSMPI 1096
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1122 WYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVglpgkggkakgkktqmaevlps 1201
Cdd:PTZ00108 1097 WSLTKEKVEKLNAELEKKEKELEKLKNTTPKDMWLEDLDKFEEALEEQEEVEEKEIAK---------------------- 1154
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1202 prgqrvipritiemkaeaekknkkkiknentegspqedgveleglKQRLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNP 1281
Cdd:PTZ00108 1155 ---------------------------------------------EQRLKSKTKGKASKLRKPKLKKKEKKKKKSSADKS 1189
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1282 WSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQK 1361
Cdd:PTZ00108 1190 KKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEFSSDDLSKEG 1269
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1362 SVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQ 1441
Cdd:PTZ00108 1270 KPKNAPKRVSAVQYSPPPPSKRPDGESNGGSKPSSPTKKKVKKRLEGSLAALKKKKKSEKKTARKKKSKTRVKQASASQS 1349
|
1450 1460 1470 1480
....*....|....*....|....*....|....*....|....
gi 530412779 1442 KPdpaKTKNRRKRKPSTSDDSDsnFEKIVSKAVTSKKSKGESDD 1485
Cdd:PTZ00108 1350 SR---LLRRPRKKKSDSSSEDD--DDSEVDDSEDEDDEDDEDDD 1388
|
|
| PLN03128 |
PLN03128 |
DNA topoisomerase 2; Provisional |
17-1167 |
0e+00 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215593 [Multi-domain] Cd Length: 1135 Bit Score: 1663.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 17 SVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYdEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVT 96
Cdd:PLN03128 2 TIEETYQKKTQLEHILLRPDTYIGSTEKHTQTLWVY-EGGEMVNREVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKVD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 97 IDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKK 176
Cdd:PLN03128 81 IDVEQNTISVYNNGKGIPVEIHKEEGVYVPELIFGHLLTSSNFDDNEKKTTGGRNGYGAKLANIFSTEFTVETADGNRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 177 MFKQTWMDNMGRAGEMELKPFNG-EDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAG-STKDVKVFLNGNKLPVKG 254
Cdd:PLN03128 161 KYKQVFTNNMSVKSEPKITSCKAsENWTKITFKPDLAKFNMTRLDEDVVALMSKRVYDIAGcLGKKLKVELNGKKLPVKS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 255 FRSYVDMYLKDKLDEtgNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNK 334
Cdd:PLN03128 241 FQDYVGLYLGPNSRE--DPLPRIYEKVNDRWEVCVSLSDGSFQQVSFVNSIATIKGGTHVDYVADQIVKHIQEKVKKKNK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 335 GGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQVQLnKK 414
Cdd:PLN03128 319 NATHVKPFQIKNHLWVFVNCLIENPTFDSQTKETLTTRPSSFGSKCELSEEFLKKVEKCGVVENILSWAQFKQQKEL-KK 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 415 CSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAE 494
Cdd:PLN03128 398 KDGAKRQRLTGIPKLDDANDAGGKKSKDCTLILTEGDSAKALAMSGLSVVGRDHYGVFPLRGKLLNVREASHKQIMKNAE 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 495 INNIIKIVGLQYKKNYeDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR-HRFLEEFITPIVKVSKNKQ 573
Cdd:PLN03128 478 ITNIKQILGLQFGKTY-DEENTKSLRYGHLMIMTDQDHDGSHIKGLIINFFHSFWPSLLKiPGFLVEFITPIVKATKGGK 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 574 EMAFYSLPEFEEWKSST-PNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDDRKEW 652
Cdd:PLN03128 557 SLSFYTMPEYEAWKESLeGETKGWTIKYYKGLGTSTSEEAKEYFSNLDIHKKEFLWQSDEDGDLIDMAFSKKRVEDRKIW 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 653 LTNFMEDrrqrkllglpeDYLyGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKV 732
Cdd:PLN03128 637 LNNYEPG-----------TFL-DQTGNGISYSDFINKELILFSQADLARSIPSMVDGLKPSQRKVLFACFKRNLKSEIKV 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 733 AQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDH 812
Cdd:PLN03128 705 AQLSGYVAEHSAYHHGEASLASTIIGMAQDFVGSNNINLLTPSGQFGTRLQGGKDAASARYIFTRLSPITRALFPKDDDV 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 813 TLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIEELAP 892
Cdd:PLN03128 785 LLNYLNEDGQSIEPEWYCPIIPMVLVNGSEGIGTGWSTFIPNYNPRDIIANIRRLLRGEELEPMHPWYRGFKGTITEVST 864
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 893 ---NQYVISGEVAILNSTTIEISELPVRTWTQTYKEqVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAE 969
Cdd:PLN03128 865 srsGSYTVTGIIEQIGDTTIRITELPVRKWTQDYKE-FLEALLTGTKKKEPEIKDFKENHTDTTVHFTVTLSEEKMARAL 943
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 970 RVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDG 1049
Cdd:PLN03128 944 AEGLEKKFKLSTTISTSNMHLFDKDGKIKKYDSPEDILEEFFHLRLDLYVKRKEVLLENLEYELKKLDNKARFILAVVKG 1023
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1050 KIIIENKPKKELIKVLIQRGYDSDPvkawKEAQQKVPDEEENEESDNEKETEKSDSvtDSGPTFNYLLDMPLWYLTKEKK 1129
Cdd:PLN03128 1024 EIVVNNRKRAELLAELEEKGFDKFP----KTAKISETNVVGDRDGEASEEEEASDN--ELAKSYDYLLGMPISSLTLEKV 1097
|
1130 1140 1150
....*....|....*....|....*....|....*...
gi 530412779 1130 DELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELE 1167
Cdd:PLN03128 1098 DELRAERAKKETEVEELKKTTPEDLWRKDLDAFEEALD 1135
|
|
| PLN03237 |
PLN03237 |
DNA topoisomerase 2; Provisional |
3-1468 |
0e+00 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215641 [Multi-domain] Cd Length: 1465 Bit Score: 1489.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 3 VNKIKKNEDAKKrlSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINyREVTFVPGLYKIFDEILVNAAD 82
Cdd:PLN03237 15 VAAAPAASSGGK--TIEEMYQKKSQLEHILLRPDTYIGSIEKHTQTLWVYETDKMVQ-RSVTYVPGLYKIFDEILVNAAD 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 83 NKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFS 162
Cdd:PLN03237 92 NKQRDPKMDSLRVVIDVEQNLISVYNNGDGVPVEIHQEEGVYVPEMIFGHLLTSSNYDDNEKKTTGGRNGYGAKLTNIFS 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 163 TKFTVETASREYKKMFKQTWMDNMGRAGE-MELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGST-KD 240
Cdd:PLN03237 172 TEFVIETADGKRQKKYKQVFSNNMGKKSEpVITKCKKSENWTKVTFKPDLAKFNMTHLEDDVVALMKKRVVDIAGCLgKT 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 241 VKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQ 320
Cdd:PLN03237 252 VKVELNGKRIPVKSFSDYVDLYLESANKSRPENLPRIYEKVNDRWEVCVSLSEGQFQQVSFVNSIATIKGGTHVDYVTNQ 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 321 IVTKLVDVVKKKNKGGvAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESIL 400
Cdd:PLN03237 332 IANHVMEAVNKKNKNA-NIKAHNVKNHLWVFVNALIDNPAFDSQTKETLTLRQSSFGSKCELSEDFLKKVMKSGIVENLL 410
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 401 NWVKFKAQVQLnKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILN 480
Cdd:PLN03237 411 SWADFKQSKEL-KKTDGAKTTRVTGIPKLEDANEAGGKNSEKCTLILTEGDSAKALAVAGLSVVGRNYYGVFPLRGKLLN 489
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 481 VREASHKQIMENAEINNIIKIVGLQYKKNYEdedSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR-HRFLE 559
Cdd:PLN03237 490 VREASHKQIMNNAEIENIKQILGLQHGKQYE---SVKSLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKvPSFLV 566
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 560 EFITPIVKVSK-NKQEMAFYSLPEFEEWKSS-TPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAI 637
Cdd:PLN03237 567 EFITPIVKATRrGKKVLSFYSMPEYEEWKESlGGNATGWSIKYYKGLGTSTAKEGKEYFKNLGKHKKDFVWEDEQDGDAI 646
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 638 SLAFSKKQIDDRKEWLTNFMedrrqrkllglPEDYLyGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKV 717
Cdd:PLN03237 647 ELAFSKKKIEARKNWLRQYE-----------PGTHL-DQTQKDVKYSDFVNKELILFSMADLQRSIPSMVDGLKPGQRKI 714
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 718 LFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTM 797
Cdd:PLN03237 715 LFCSFKRNFVKEAKVAQLSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRLQGGKDHASARYIFTR 794
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 798 LSSLARLLFPPKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPML 877
Cdd:PLN03237 795 LSPITRFLFPKDDDILLDYLNEDGQSIEPTWYMPIIPTVLVNGAEGIGTGWSTFIPNYNPRDIVANIRRLLNGESMEPMH 874
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 878 PSYKNFKGTIEELAPNQ----YVISGEVAILNSTTIEISELPVRTWTQTYKEqVLEPMLNGTEKTP-PLITDYREYHTDT 952
Cdd:PLN03237 875 PWYRGFKGTIEKTASKEggctYTITGLYEEVDETTLRITELPIRRWTDDYKE-FLESLKTDNNKNKdPFIKDVKAYNDDT 953
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 953 TVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAE 1032
Cdd:PLN03237 954 TVHFEVILSEENMLAAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEQILEEFFHLRLEYYEKRKEVLLKNLEFE 1033
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1033 SAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAwKEAQQKVPDEEENEESDNEKETEKSDSVTDsGPT 1112
Cdd:PLN03237 1034 LLKLENKVRFILAVVDGEIIVNNRKKADLVEELRQKGFTPFPKKA-KSVEAAVAGATDDAAEEEEEIDVSSSSGVR-GSD 1111
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1113 FNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKAkgkk 1192
Cdd:PLN03237 1112 YDYLLSMAIGTLTLEKVQELCADRDKLNIEVEDLKKTTPKSLWLKDLDALEKELDKLDKEDAKAEEAREKLQRAAA---- 1187
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1193 tqMAEVLPSPRGQRVIPRitiemkaeaekknKKKIKNENTEGSPQEDGVELEGlKQRLEKKQKREPGTKTKKQTTLAFKP 1272
Cdd:PLN03237 1188 --RGESGAAKKVSRQAPK-------------KPAPKKTTKKASESETTEETYG-SSAMETENVAEVVKPKGRAGAKKKAP 1251
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1273 IKKGKKRNPWSDSESDRSSDESNFDVPP-----RETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTK 1347
Cdd:PLN03237 1252 AAAKEKEEEDEILDLKDRLAAYNLDSAPaqsakMEETVKAVPARRAAARKKPLASVSVISDSDDDDDDFAVEVSLAERLK 1331
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1348 ---------------TSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPpathfpdETEI----TNPVPKKNVTVKKTA 1408
Cdd:PLN03237 1332 kkggrkpaaankkaaKPPAAAKKRGPATVQSGQKLLTEMLKPAEAIGISP-------EKKVrkmrASPFNKKSGSVLGRA 1404
|
1450 1460 1470 1480 1490 1500
....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1409 AKSQSSTSTTGAkkrAAPKGTKRDPAlnsGVSQKPDPAktknRRKRKPSTSDDSDSNFEK 1468
Cdd:PLN03237 1405 ATNKETESSENV---SGSSSSEKDEI---DVSAKPRPQ----RANRKQTTYVLSDSESES 1454
|
|
| TOP2c |
smart00433 |
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE |
68-657 |
0e+00 |
|
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
Pssm-ID: 214659 [Multi-domain] Cd Length: 594 Bit Score: 776.73 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 68 GLYKIFDEILVNAADNKQRDPkMSCIRVTIDPENnLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVT 147
Cdd:smart00433 1 GLHHLVDEIVDNAADEALAGY-MDTIKVTIDKDN-SISVEDNGRGIPVEIHPKEKKYAPEVIFTVLHAGGKFDDDAYKVS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 148 GGRNGYGAKLCNIFSTKFTVETASReyKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSldKDIVALM 227
Cdd:smart00433 79 GGLHGVGASVVNALSTEFEVEVARD--GKEYKQSFSNNGKPLSEPKIIGDTKKDGTKVTFKPDLEIFGMTT--DDDFELL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 228 VRRAYDIAGSTKDVKVFLNGNK-------LPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKG-FQQI 299
Cdd:smart00433 155 KRRLRELAFLNKGVKITLNDERsdeektfLFEGGIKDYVELLNKNKELLSPEPTYIEGEKDNIRVEVAFQYTDGYsENIV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 300 SFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVA-VKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFG- 377
Cdd:smart00433 235 SFVNNIATTEGGTHENGFKDALTRVINEYAKKKKKLKEKnIKGEDVREGLTAFISVKIPEPQFEGQTKEKLGTSEVRFGv 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 378 ----STCQLSEKFIKAAIGCGIVESILNWVKFKAQVQ-LNKKCSAVKHNRIKGIPKLDDANDAGGRnstECTLILTEGDS 452
Cdd:smart00433 315 ekivSECLLSFLEENPVEASKIVEKVLLAAKARAAAKkARELTRKKKLSSISLPGKLADASSAGPK---KCELFLVEGDS 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 453 AKTLAVSGLgvvGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYededSLKTLRYGKIMIMTDQDQ 532
Cdd:smart00433 392 AGGSAKSGR---DRDFQAILPLRGKILNVEKASLDKILKNEEIQALITALGLGIGKDF----DIEKLRYGKIIIMTDADV 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 533 DGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQ--EMAFYSLPEFEEWKSSTPNHK-KWKVKYYKGLGTSTS 609
Cdd:smart00433 465 DGSHIKGLLLTFFYRYMPPLIEAGFVYIAIPPLYKVTKGKKkyVYSFYSLDEYEKWLEKTEGNKsKYEIQRYKGLGEMNA 544
|
570 580 590 600
....*....|....*....|....*....|....*....|....*....
gi 530412779 610 KEAKEYFADMKRHRIQFKYSGPEDDA-AISLAFSKKQIDDRKEWLTNFM 657
Cdd:smart00433 545 DQLWETTMDPERRTLLFVTLDDADEAdLIFSALMGDKVEPRKEWIEENA 593
|
|
| TOP4c |
smart00434 |
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC |
681-1157 |
0e+00 |
|
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
Pssm-ID: 214660 [Multi-domain] Cd Length: 444 Bit Score: 566.81 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 681 LTYNDFINKELILFSNS-DNERSIPSMVDGLKPGQRKVLFTCFKRNDKR-EVKVAQLAGSVAEMSSYH-HGEMSLMMTII 757
Cdd:smart00434 1 IDIEDFINKEYLDYSMSvINGRAIPDVRDGLKPVQRRILYAMFKRGLTPdEPKVKSARGVGDVMGKYHpHGDSSLYDTIV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 758 NLAQNFVgsNNLNLLQPIGQFGTRLhGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYD-DNQRVEPEWYIPIIPMV 836
Cdd:smart00434 81 RMAQDFS--NNYPLLDGQGNFGSRL-DGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNyDGQEIEPTVLPPIIPNL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 837 LINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEP----LPMLPSYKNFKGTIEELAPNQYVISGEVAILNSTTIEIS 912
Cdd:smart00434 158 LVNGSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDAsideLMMIPWGPDFPTGGEIVGPGKYVVRGKIEIEDDNTIVIT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 913 ELPVRTWTQTYKEQVLEPMLNGteKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFD 992
Cdd:smart00434 238 ELPYQVNTADLIEKIAELVKDK--KIEGIIDVRDESHDRTGVRIVIELKRGAMAEVVLNGLYKLTKLQTTFSINMLALFD 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 993 HvGCLKKYDTVlDILRDFFELRLKYYGLRKEWLLGMLGAEsAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDS 1072
Cdd:smart00434 316 N-GRPKKYNLK-EILKEFLDHRLEVYTRRKEYLLGKLEAE-RLHILEGLFIALSIIDEIIVLIRSSKDLAKEAKEKLMER 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1073 dpvkawkeaqqkvpdeeeneesdneketeksdsVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPS 1152
Cdd:smart00434 393 ---------------------------------FELSEIQADAILDMRLRRLTKLEVEKLEKELKELEKEIEDLEKILAS 439
|
....*
gi 530412779 1153 DLWKE 1157
Cdd:smart00434 440 EEWLN 444
|
|
| TOP4c |
cd00187 |
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ... |
699-1162 |
8.52e-171 |
|
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.
Pssm-ID: 238111 [Multi-domain] Cd Length: 445 Bit Score: 519.82 E-value: 8.52e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 699 NERSIPSMVDGLKPGQRKVLFTCFKRN---DKREVKVAQLAGSVAEMSsYHHGEMSLMMTIINLAQNFvgSNNLNLLQPI 775
Cdd:cd00187 1 NGRALPDVRDGLKPVQRRILYAMFKRGltpDKPEKKVARLVGDVAGKY-HPHGDSSLYDTIVRMAQDF--SNNIPLLDPQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 776 GQFGTRlhGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYD-DNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPN 854
Cdd:cd00187 78 GNFGSR--DGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNyDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 855 FDVREIVNNIRRLMDGEEP-------LPMLPSYKNFkGTIEELA---------PNQYVISGEVAIL---NSTTIEISELP 915
Cdd:cd00187 156 HNLREVIDALRALIDNPEAsidelmeIIKGPDFPTG-GIIEGRAgireayetgRGRYIIRGKYEIEddeGRNTIEITELP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 916 VRTWTQTYKEQVLEPMlngTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNsMVLFDHVG 995
Cdd:cd00187 235 YQVNKAKLKEKIAELV---KDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGIN-MVAFDPNG 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 996 CLKKYdTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKID--GKIIIENKPKKELIKVLIQRGYDSD 1073
Cdd:cd00187 311 RPKKL-NLKEILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILNIDEviNLIRSSDEAKKALIEELEKLGFSEI 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1074 pvkawkeaqqkvpdeeeneesdneketeksdsvtdsgpTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKS--- 1150
Cdd:cd00187 390 --------------------------------------QADAILDMRLRRLTKLEREKLLKELKELEAEIEDLEKILase 431
|
490
....*....|....
gi 530412779 1151 --PSDLWKEDLATF 1162
Cdd:cd00187 432 erPKDLWKEELDEF 445
|
|
| DNA_topoisoIV |
pfam00521 |
DNA gyrase/topoisomerase IV, subunit A; |
701-1159 |
3.10e-158 |
|
DNA gyrase/topoisomerase IV, subunit A;
Pssm-ID: 459843 [Multi-domain] Cd Length: 432 Bit Score: 485.90 E-value: 3.10e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 701 RSIPSMVDGLKPGQRKVLFTCFK--RNDKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFVGsnNLNLLQPIGQ 777
Cdd:pfam00521 1 RAIPDVRDGLKPVQRRILYAMFEllNLDKPYKKVARLVGDV--MGKYHpHGDASLYDAIVRMAQDFVG--NIPLLDGQGN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 778 FGTRLHGGKDsASPRYIFTMLSSLARLLFPPKDDHTLKFLYD-DNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFD 856
Cdd:pfam00521 77 FGSRIDGDKD-AAMRYTETRLSKIARELFPDIDDDTVDYVPNyDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 857 VREIVNNIRRLMDGEEP-----LPMLPSYKNFKGTIEELAP--------NQYVISGEVAILNSTTIEISELPVRTWTQTY 923
Cdd:pfam00521 156 LREIIDALIALLDGPEAtllmkYIMGPDFPTGGGIIGKGGIkeayktgrGKITVRAKVEIEDRKTIVITELPYGVWTSDL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 924 KEQvLEPMLNgtEKTPPLITDYREYhTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVgclKKYDTV 1003
Cdd:pfam00521 236 IEK-IEELVK--NGKIKGISDIRDE-SDRGVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLFDGG---PKYLGL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1004 LDILRDFFELRLKYYGLRKEWLLGMLGAESAKLN------NQARFILEKIDGKiIIENKPKKELIKVLiqrgydsdpvka 1077
Cdd:pfam00521 309 KEILKEFLDHRLEVYERRKEYLLEKLEERLHILEgllialNNIDFVIEIIRGS-IDRKKAKKNLIEEL------------ 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1078 wKEAQqkvpdeeeneesdneketeksdsvtdsgptFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPS----- 1152
Cdd:pfam00521 376 -SEIQ------------------------------ADYLLDMRLRRLTKEEVDKLLEEIDELEKEIAELEKLLASekkln 424
|
....*..
gi 530412779 1153 DLWKEDL 1159
Cdd:pfam00521 425 DLWIEEL 431
|
|
| HATPase_TopII-like |
cd16930 |
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the ... |
65-210 |
5.44e-96 |
|
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the histidine kinase-like ATPase (HATpase) domains of human topoisomerase IIA (TopIIA) and TopIIB, Saccharomyces cerevisae TOP2p, and related proteins. These proteins catalyze the passage of DNA double strands through a transient double-strand break in the presence of ATP.
Pssm-ID: 340407 [Multi-domain] Cd Length: 147 Bit Score: 305.03 E-value: 5.44e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 65 FVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEK 144
Cdd:cd16930 1 YVPGLYKIFDEILVNAADNKQRDKSMTCIKVTIDPENNEISVWNNGKGIPVVIHKEEKIYVPEMIFGHLLTSSNYDDDEK 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530412779 145 KVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPF-NGEDYTCITFQPD 210
Cdd:cd16930 81 KVTGGRNGYGAKLCNIFSTEFTVETADSESKKKFKQTWTNNMGKASEPKITPYeKGKDYTKVTFKPD 147
|
|
| TopoIIA_Trans_ScTopoIIA |
cd03481 |
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the ... |
253-405 |
7.11e-89 |
|
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded by a single gene. The type IIA enzymes are the predominant form of topoisomerase and are found in some bacteriophages, viruses and archaea, and in all bacteria and eukaryotes. All type IIA topoisomerases are related to each other at amino acid sequence level, though their oligomeric organization sometimes differs. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. TopoIIA enzymes also catenate/ decatenate duplex rings. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes.
Pssm-ID: 239563 [Multi-domain] Cd Length: 153 Bit Score: 285.33 E-value: 7.11e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 253 KGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKK 332
Cdd:cd03481 1 KSFKDYVKLYLKDANKEDGPPPPVVYEPVNDRWEVAVALSDGQFQQVSFVNSIATTKGGTHVDYVADQIVKKLDEVVKKK 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530412779 333 NKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKF 405
Cdd:cd03481 81 NKGGINVKPFQVKNHLWIFVNCLIENPSFDSQTKETLTTKPKSFGSKCELSEKFLKKAVKSGIVESVLSWAKF 153
|
|
| 39 |
PHA02569 |
DNA topoisomerase II large subunit; Provisional |
29-654 |
9.60e-85 |
|
DNA topoisomerase II large subunit; Provisional
Pssm-ID: 177398 [Multi-domain] Cd Length: 602 Bit Score: 290.50 E-value: 9.60e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 29 EHILLRPDTYIGSVELVTQQMWVYDedvgiNYREVTFVPGLYKIFDEILVNAADNKQR-DPKMS-CIRVTIDpeNNLISI 106
Cdd:PHA02569 11 EHILKRPGMYIGSVAYEAHERFLFG-----KFTQVEYVPGLVKIIDEIIDNSVDEAIRtNFKFAnKIDVTIK--NNQVTV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 107 WNNGKGIP---VVEHKVEKMYVPALIFGQLLTSSNYDDDEKkVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQT-W 182
Cdd:PHA02569 84 SDNGRGIPqamVTTPEGEEIPGPVAAWTRTKAGSNFDDTNR-VTGGMNGVGSSLTNFFSVLFIGETCDGKNEVTVNCSnG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 183 MDNMGrageMELKPfNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKgFRSYVDMY 262
Cdd:PHA02569 163 AENIS----WSTKP-GKGKGTSVTFIPDFSHFEVNGLDQQYLDIILDRLQTLAVVFPDIKFTFNGKKVSGK-FKKYAKQF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 263 LKDKldetgnslkVIHEqvNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKggVAVKAH 342
Cdd:PHA02569 237 GDDT---------IVQE--NDNVSIALAPSPDGFRQLSFVNGLHTKNGGHHVDCVMDDICEELIPMIKKKHK--IEVTKA 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 343 QVKN--HMWIFVNALIeNPTFDSQTKENMTLQPKSFGSTCQLSEKFI------KAAIGCGIVESIL--NWVKFKAQVQLN 412
Cdd:PHA02569 304 RVKEclTIVLFVRNMS-NPRFDSQTKERLTSPFGEIRNHIDLDYKKIakqilkTEAIIMPIIEAALarKLAAEKAAETKA 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 413 KKcSAVKHNRIKGIPklddANDAGgrNSTECTLILTEGDSAKTLAVSglgVVGRDKYGVFPLRGKILNVREASHKQIMEN 492
Cdd:PHA02569 383 AK-KAKKAKVAKHIK----ANLIG--KDAETTLFLTEGDSAIGYLIE---VRDEELHGGYPLRGKVLNTWGMSYADILKN 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 493 AEINNIIKIVGLQYKknyEDEDSLKtlrYGKIMIMTDQDQDG-SHIKGLLINFIhHNWPSLL---RHRFLEefiTPIVKV 568
Cdd:PHA02569 453 KELFDICAITGLVLG---EKAENMN---YKNIAIMTDADVDGkGSIYPLLLAFF-SRWPELFeqgRIRFVK---TPVIIA 522
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 569 SKNKQEMAFYSLPEFEEWKSStpnHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEddaAISLAFSKKQiDD 648
Cdd:PHA02569 523 QVGKETKWFYSLDEFEKAKDS---LKKWSIRYIKGLGSLRKSEYRRVINNPVYDVVVLPDDWKE---LFEMLFGDDA-DL 595
|
....*.
gi 530412779 649 RKEWLT 654
Cdd:PHA02569 596 RKDWMS 601
|
|
| TOPRIM_TopoIIA |
cd03365 |
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
443-563 |
1.92e-77 |
|
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173785 [Multi-domain] Cd Length: 120 Bit Score: 251.07 E-value: 1.92e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 443 CTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKnyEDEDSLKTLRYG 522
Cdd:cd03365 1 CTLILTEGDSAKALAVAGLSVVGRDYYGVFPLRGKLLNVREASHKQIMENAEIQNIKKILGLQHGK--SDYESTKSLRYG 78
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 530412779 523 KIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHR-FLEEFIT 563
Cdd:cd03365 79 RLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKIPgFLVEFIT 120
|
|
| 52 |
PHA02592 |
DNA topisomerase II medium subunit; Provisional |
679-1167 |
3.12e-77 |
|
DNA topisomerase II medium subunit; Provisional
Pssm-ID: 222896 [Multi-domain] Cd Length: 439 Bit Score: 263.46 E-value: 3.12e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 679 TYLTYNDFINKELILFSNSD-NERSIPSMVDGLKPGQRKVLFTC--FKRNDKREV-KVAQLAGSVAEMSsYHHGEMSLMM 754
Cdd:PHA02592 4 KERSLKSIVNNEALEYAMYTvEERAIPNLIDGLKPVQRFVIHRAleYAKGNKEKFdKVAAIAGGVADLG-YHHGETSAQD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 755 TIINLAQNFvgSNNLNLLQPIGQFGTRLhgGKDSASPRYIFTMLSSLARLLFppKDDHtLKFLYDDNQRVEPEWYIPIIP 834
Cdd:PHA02592 83 AGALMANTW--NNNIPLLDGQGNFGSRL--VQKAAAARYIFARVHDNFRKIY--KDED-LAPVHEDPEHIPPAFYLPIIP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 835 MVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIEELAPNQYVISGEVAILNSTTIEISEL 914
Cdd:PHA02592 156 MVLLNGVSGIATGYATNILPHSPKSVIKAVLAALNGKDITEPKVQFPEFKGEVVEIEPGSYEIRGTYELNGKTKLHITEI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 915 PVRTWTQTYKEqVLEPMLngtEKTppLITDYREYHTDtTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLfDHV 994
Cdd:PHA02592 236 PVKYDRETYVA-VLDPLE---EKG--KIVSYDDCTED-GFRFKVTLKREENEEATHEKIMKDFGLIERVSQNITVI-NEN 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 995 GCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLiqrgydsdp 1074
Cdd:PHA02592 308 GKLKVYENAEDLIRDFVEIRKTYVQKRIQYEIKETEEAFDLALAKAEFIKRVIAGEIVLQGKTRSELTEEL--------- 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1075 vKAWKeaqqkvpdeeeneesdneketeksdsvtDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDL 1154
Cdd:PHA02592 379 -SDNK----------------------------DFGEYADKLVAMNIYSMTSDEREKLQKEAEELEKEHEYWKKTTAKKE 429
|
490
....*....|...
gi 530412779 1155 WKEDLatfiEELE 1167
Cdd:PHA02592 430 YIKDL----EELK 438
|
|
| TOPRIM_C |
pfam16898 |
C-terminal associated domain of TOPRIM; TOPRIM_C is found as the C-terminal extension of the ... |
561-699 |
1.74e-75 |
|
C-terminal associated domain of TOPRIM; TOPRIM_C is found as the C-terminal extension of the TOPRIM domain, pfam01751 in metazoa.
Pssm-ID: 465302 [Multi-domain] Cd Length: 127 Bit Score: 245.89 E-value: 1.74e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 561 FITPIVKVSKNKQEMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLA 640
Cdd:pfam16898 1 FITPIVKVTKGKEVISFFSLPEYEEWKESTPNLKGWKIKYYKGLGTSTSEEAKEYFSNLDKHRKEFKYLGDDDDEAIDLA 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 530412779 641 FSKKQIDDRKEWLTNFMedrrqrkllglPEDYLYgQTTTYLTYNDFINKELILFSNSDN 699
Cdd:pfam16898 81 FSKKKADDRKEWLRNFN-----------PGTYLD-HSTKEISYSDFINKELILFSMADN 127
|
|
| TOPRIM_TopoIIA_like |
cd01030 |
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ... |
443-563 |
2.95e-63 |
|
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173780 [Multi-domain] Cd Length: 115 Bit Score: 210.44 E-value: 2.95e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 443 CTLILTEGDSAKTLAVSGLGVVgrdKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDedsLKTLRYG 522
Cdd:cd01030 1 CELILVEGDSAGGSAKQGRDRV---FQAVFPLRGKILNVEKASLKKILKNEEIQNIIKALGLGIGKDDFD---LDKLRYG 74
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 530412779 523 KIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFIT 563
Cdd:cd01030 75 KIIIMTDADVDGSHIRTLLLTFFYRFWPSLLENGFLYIAQT 115
|
|
| PRK05559 |
PRK05559 |
DNA topoisomerase IV subunit B; Reviewed |
28-605 |
1.06e-53 |
|
DNA topoisomerase IV subunit B; Reviewed
Pssm-ID: 235501 [Multi-domain] Cd Length: 631 Bit Score: 199.94 E-value: 1.06e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 28 LEHILLRPDTYIGSvelvtqqmwvYDEDvginyrevtfvpGLYKIFDEILVNAAD-------NKqrdpkmscIRVTIDpE 100
Cdd:PRK05559 19 LEPVRKRPGMYIGS----------TDTR------------GLHHLVQEVIDNSVDealaghgKR--------IEVTLH-A 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 101 NNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETAsREyKKMFKQ 180
Cdd:PRK05559 68 DGSVSVRDNGRGIPVGIHPEEGKSGVEVILTKLHAGGKFSNKAYKFSGGLHGVGVSVVNALSSRLEVEVK-RD-GKVYRQ 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 181 TWmDNMGRAGEMEL--KPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRR-AYDIAGstkdVKVFLNGNKLPVKgFRS 257
Cdd:PRK05559 146 RF-EGGDPVGPLEVvgTAGKRKTGTRVRFWPDPKIFDSPKFSPERLKERLRSkAFLLPG----LTITLNDERERQT-FHY 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 258 yvDMYLKDKLDETGNSLKVIHEQVNHRW---------EVCLTMSEKGFQQI-SFVNSIATSKGGRHVDYVADQIVTKLVD 327
Cdd:PRK05559 220 --ENGLKDYLAELNEGKETLPEEFVGSFegeaegeavEWALQWTDEGGENIeSYVNLIPTPQGGTHENGFREGLLKAVRE 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 328 VVKKKN--KGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMtlqpksfGST-CQ-LSEKFIKAAIG------CGIVE 397
Cdd:PRK05559 298 FAEKRNllPKGKKLEGEDVREGLAAVLSVKIPEPQFEGQTKEKL-------GSReARrFVSGVVKDAFDlwlnqnPELAE 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 398 SILNWVKFKAQVQLNKKCSAVKHNRIKGI---PKLddaNDAGGRNSTECTLILTEGDSAktlavSGLGVVGRDKY--GVF 472
Cdd:PRK05559 371 KLAEKAIKAAQARLRAAKKVKRKKKTSGPalpGKL---ADCTSQDPERTELFLVEGDSA-----GGSAKQARDREfqAIL 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 473 PLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDslktLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSL 552
Cdd:PRK05559 443 PLRGKILNTWEASLDDVLANEEIHDIIVAIGIGPGDSFDLED----LRYGKIIIMTDADVDGAHIATLLLTFFYRHFPPL 518
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*.
gi 530412779 553 LR--HRFLEEfiTPIVKVSKNKQEMAFYSLPEFEEW-KSSTPNHKKWKVKYYKGLG 605
Cdd:PRK05559 519 VEagHVYIAL--PPLYRVDKGKKKIYALDEEEKEELlKKLGKKGGKPEIQRFKGLG 572
|
|
| GyrB |
COG0187 |
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair]; |
28-605 |
2.84e-40 |
|
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
Pssm-ID: 439957 [Multi-domain] Cd Length: 635 Bit Score: 159.42 E-value: 2.84e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 28 LEHILLRPDTYIGSVelvtqqmwvyDEDvginyrevtfvpGLYKIFDEILVNA--------ADNkqrdpkmscIRVTIDp 99
Cdd:COG0187 17 LEAVRKRPGMYIGST----------DER------------GLHHLVWEIVDNSidealagyCDR---------IEVTLH- 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 100 ENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETAsREyKKMFK 179
Cdd:COG0187 65 ADGSVTVEDNGRGIPVDIHPKEGKSALEVVLTVLHAGGKFDGGSYKVSGGLHGVGASVVNALSERLEVEVK-RD-GKIYR 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 180 QTWMDnmGRAGEmELKpfNGEDY----TCITFQPDLSKFKMQSLDKDIVALMVRRaydiagstkdvKVFLNGN------- 248
Cdd:COG0187 143 QRFER--GKPVG-PLE--KIGKTdrtgTTVRFKPDPEIFETTEFDYETLAERLRE-----------LAFLNKGltitltd 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 249 ---KLPVK-------GFRSYVDMYLKDKldetgnslKVIHEQV--------NHRWEVCLTMSEKGFQQI-SFVNSIATSK 309
Cdd:COG0187 207 ereEEPKEetfhyegGIKDFVEYLNEDK--------EPLHPEViyfegekdGIEVEVALQWNDGYSENIhSFVNNINTPE 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 310 GGRHV------------DYVadqivtKLVDVVKKKNK---------GGVAVkahqvknhmwifVNALIENPTFDSQTKEn 368
Cdd:COG0187 279 GGTHEtgfrtaltrvinDYA------RKNGLLKEKDKnltgddvreGLTAV------------ISVKLPEPQFEGQTKT- 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 369 mtlqpksfgstcQLSEKFIKaaigcGIVESILN----------------WVKF-----------KAQVQLNKKCSAVKHN 421
Cdd:COG0187 340 ------------KLGNSEAR-----GIVESVVSeklehyleenpaeakkILEKailaarareaaRKARELVRRKSALESS 402
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 422 RIKGipKLDDANDaggRNSTECTLILTEGDSA----KTlavsglgvvGRD-KY-GVFPLRGKILNVREASHKQIMENAEI 495
Cdd:COG0187 403 GLPG--KLADCSS---KDPEESELFIVEGDSAggsaKQ---------GRDrEFqAILPLRGKILNVEKARLDKILKNEEI 468
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 496 NNIIKIVGLQYKKNYEDEDslktLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLeeFI--TPIVKVSKNKQ 573
Cdd:COG0187 469 RDLITALGTGIGDDFDLEK----LRYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIEAGHV--YIaqPPLYRIKKGKK 542
|
650 660 670
....*....|....*....|....*....|..
gi 530412779 574 EMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLG 605
Cdd:COG0187 543 TYYAYSDAELDELLKELKGKKKVEIQRYKGLG 574
|
|
| gyrB |
PRK05644 |
DNA gyrase subunit B; Validated |
28-605 |
7.25e-35 |
|
DNA gyrase subunit B; Validated
Pssm-ID: 235542 [Multi-domain] Cd Length: 638 Bit Score: 142.93 E-value: 7.25e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 28 LEHILLRPDTYIGSvelvtqqmwvydedvginyrevTFVPGLYKIFDEILVNA--------ADNkqrdpkmscIRVTIDP 99
Cdd:PRK05644 19 LEAVRKRPGMYIGS----------------------TGERGLHHLVYEIVDNSidealagyCDH---------IEVTINE 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 100 eNNLISIWNNGKGIPVVEHKVEKmyVPAL--IFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETaSREYKKm 177
Cdd:PRK05644 68 -DGSITVTDNGRGIPVDIHPKTG--KPAVevVLTVLHAGGKFGGGGYKVSGGLHGVGVSVVNALSTWLEVEV-KRDGKI- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 178 FKQTWMDnmGR-AGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVAlmvRRAYDIAGSTKDVKVFL----NGNKLPV 252
Cdd:PRK05644 143 YYQEYER--GVpVTPLEVIGETDETGTTVTFKPDPEIFETTEFDYDTLA---TRLRELAFLNKGLKITLtderEGEEKEE 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 253 K-----GFRSYVDmYL-KDKldetgnslKVIHEQV--------NHRWEVCLTMSEkGFQQ--ISFVNSIATSKGGRHVD- 315
Cdd:PRK05644 218 TfhyegGIKEYVE-YLnRNK--------EPLHEEPiyfegekdGIEVEVAMQYND-GYSEniLSFANNINTHEGGTHEEg 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 316 -YVAdqiVTKLV-DVVKKKNK---------------GGVAVKAhqVKnhmwifvnalIENPTFDSQTK------ENMTLQ 372
Cdd:PRK05644 288 fKTA---LTRVInDYARKNKLlkekddnltgedvreGLTAVIS--VK----------HPEPQFEGQTKtklgnsEVRGIV 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 373 PKSFGStcQLSEKF------IKAaigcgIVESILNwvKFKAQVqlnkkcsAVKHNR----------IKGIP-KLDDANDa 435
Cdd:PRK05644 353 DSVVSE--ALSEFLeenpnvAKK-----IVEKAIL--AARARE-------AARKAReltrrksaleSSSLPgKLADCSS- 415
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 436 ggRNSTECTLILTEGDSAKTLAVSGlgvvgRDKY--GVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKknyeDE 513
Cdd:PRK05644 416 --KDPEESELYIVEGDSAGGSAKQG-----RDRRfqAILPLRGKILNVEKARLDKILKNEEIRALITALGTGIG----DD 484
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 514 DSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIhhnwpsllrHRFLEEFIT---------PIVKVSKNKQEMAfYSLPEFE 584
Cdd:PRK05644 485 FDISKLRYHKIIIMTDADVDGAHIRTLLLTFF---------YRYMRPLIEagyvyiaqpPLYKIKKGGKEYA-YSDEELD 554
|
650 660
....*....|....*....|...
gi 530412779 585 EWKSSTPNH--KKWKVKYYKGLG 605
Cdd:PRK05644 555 EILAELKLKgnPKYGIQRYKGLG 577
|
|
| DTHCT |
pfam08070 |
DTHCT (NUC029) region; The DTCHT region is the C-terminal part of DNA gyrases B / ... |
1423-1510 |
8.57e-34 |
|
DTHCT (NUC029) region; The DTCHT region is the C-terminal part of DNA gyrases B / topoisomerase IV / HATPase proteins. This region is composed of quite low complexity sequence.
Pssm-ID: 462355 [Multi-domain] Cd Length: 97 Bit Score: 125.64 E-value: 8.57e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 1423 RAAPKGTKR------DPALNSGVSQKPDPAKTKNRRKRKPSTS-DDSDSNFEKIVSKAVTSKKSKG--ESDDFHMDFDSA 1493
Cdd:pfam08070 1 KAAPKAAKAadksssDSDSDAGASKKPAPPKGRKARKRKPSSSsDDSDSDFGKKPSKAVAKKKSKKvsDDDDFSVDLDSE 80
|
90
....*....|....*..
gi 530412779 1494 VAPRAKSVRAKKPIKYL 1510
Cdd:pfam08070 81 VAPRARPGRAKKPVKYL 97
|
|
| DNA_gyraseB |
pfam00204 |
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal ... |
254-414 |
2.48e-31 |
|
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal S5 domain 2-like fold. This family is structurally related to PF01119.
Pssm-ID: 425522 [Multi-domain] Cd Length: 173 Bit Score: 121.57 E-value: 2.48e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 254 GFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTM---SEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVK 330
Cdd:pfam00204 1 GLKDFVEELNKDKKPLHKEIIYFEGESPDNRIEVEVALqwtDSYSENILSFVNNIATPEGGTHVDGFKSALTRTINEYAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 331 KKN---KGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGC-GIVESILNWVKFK 406
Cdd:pfam00204 81 KKGllkKKDEKITGEDIREGLTAVVSVKIPDPQFEGQTKEKLGNPEVKSAVEKIVSEKLEEFLEENpEIAKKILEKALQA 160
|
....*...
gi 530412779 407 AQVQLNKK 414
Cdd:pfam00204 161 AKARLAAR 168
|
|
| PRK09631 |
PRK09631 |
DNA topoisomerase IV subunit A; Provisional |
700-1061 |
5.69e-24 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 236598 [Multi-domain] Cd Length: 635 Bit Score: 109.03 E-value: 5.69e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 700 ERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGsvaEMSSYH-HGEMSLMMTIINLAqnfvgsNNLNLLQPIGQF 778
Cdd:PRK09631 22 DRAIPDVIDGLKPVQRRILHSLFEMHDGKFHKVANVVG---NTMKYHpHGDASIYEALVNLA------NKDLFIDKQGNF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 779 GTRLHGgkDSAS-PRYIFTMLSSLARLLFPPKDDHTLKFLYdDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDV 857
Cdd:PRK09631 93 GNLFTG--DPASaARYIECRLTPLAKEVLYNKEITEYEPSY-DGRNNEPLCLPAKIPVILIQGAEGIAVGMATKILPHNF 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 858 REIVNNIRRLMDGeEPLPMLPSYKNfkGTIEELapNQY-------VISGEVAILNSTTIEISELPVRTWTQTYKEQVLEP 930
Cdd:PRK09631 170 NEILQAVKSELLG-ESFALYPDFPT--GGIVDV--SEYadgngkvLVRAKIETKDEKTIVIREIPFGTTTESLIASIEKA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 931 MLNGTEKTPPlITDYreyhTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHvgcLKKYDTVLDILRdF 1010
Cdd:PRK09631 245 ARKGKIKISS-INDY----TAENVEIEIKLPRGVYASEVIEALYAYTDCEVSISVNLLVIKDR---YPVIYTVTDIIK-F 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 530412779 1011 FELRLKYYgLRKEwllgmLGAESAKLnnqarfiLEKIDGK----IIIENKPKKEL 1061
Cdd:PRK09631 316 HAEHLQKV-LKME-----LELERAKL-------LEKIFAKtleqIFIEERIYKRI 357
|
|
| TOPRIM_TopoIIA_GyrB |
cd03366 |
TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ... |
443-553 |
6.03e-24 |
|
TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. DNA gyrase is more effective at relaxing supercoils than decatentating DNA. DNA gyrase in addition inserts negative supercoils in the presence of ATP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173786 [Multi-domain] Cd Length: 114 Bit Score: 98.11 E-value: 6.03e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 443 CTLILTEGDSAktlavSGLGVVGRDKY--GVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEdedsLKTLR 520
Cdd:cd03366 1 SELYIVEGDSA-----GGSAKQGRDRRfqAILPLRGKILNVEKARLDKILKNEEIRALITALGTGIGEDFD----LEKLR 71
|
90 100 110
....*....|....*....|....*....|...
gi 530412779 521 YGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLL 553
Cdd:cd03366 72 YHKIIIMTDADVDGAHIRTLLLTFFFRYMRPLI 104
|
|
| PTZ00109 |
PTZ00109 |
DNA gyrase subunit b; Provisional |
254-643 |
5.15e-19 |
|
DNA gyrase subunit b; Provisional
Pssm-ID: 240272 [Multi-domain] Cd Length: 903 Bit Score: 93.79 E-value: 5.15e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 254 GFRSYVDMYLKDKL----DETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSkGGRHVDYVADQIvTKLVDVV 329
Cdd:PTZ00109 376 GTREFLEELIKDKTplykDINIISIRGVIKNVNVEVSLSWSLESYTALIKSFANNVSTT-AGTHIDGFKYAI-TRCVNGN 453
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 330 KKKN---KGG-VAVKAHQVKNHMWIFVNALIENPTFDSQTKEnmtlqpksfgstcQLSEKFIKAaigcgIVESILNWvKF 405
Cdd:PTZ00109 454 IKKNgyfKGNfVNIPGEFIREGMTAIISVKLNGAEFDGQTKT-------------KLGNHLLKT-----ILESIVFE-QL 514
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 406 KAQVQLNKKCSAVKHNRIKGIPKLDDANDAG-----GRNS-----------TECT--------LILTEGDSAktlAVSGL 461
Cdd:PTZ00109 515 SEILEFEPNLLLAIYNKSLAAKKAFEEAKAAkdlirQKNNqyystilpgklVDCIsddierneLFIVEGESA---AGNAK 591
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 462 GVVGRDKYGVFPLRGKILNVRE-ASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLK----------------------- 517
Cdd:PTZ00109 592 QARNREFQAVLPLKGKILNIEKiKNNKKVFENSEIKLLITSIGLSVNPVTWRQYDLShgtkaskdesvqnnnstltkkkn 671
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 518 -----TLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQemafyslpefEEWKSSTPN 592
Cdd:PTZ00109 672 slfdtPLRYGKIILLTDADVDGEHLRILLLTLLYRFCPSLYEHGRVYVACPPLYRITNNRM----------KQFNVSTKN 741
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 530412779 593 HKKWKVKYYKGLGTSTSKE-AKEYFADMKRHRIQFKYSGPEDDAAISLAFSK 643
Cdd:PTZ00109 742 SKKYIYTWSDEELNVLIKLlNKDYSSKETTRSVEEKGNAPDLDNEYEDEKLD 793
|
|
| gyrA |
TIGR01063 |
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ... |
701-1077 |
1.01e-18 |
|
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273423 [Multi-domain] Cd Length: 800 Bit Score: 92.76 E-value: 1.01e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 701 RSIPSMVDGLKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFvgSNNLNLLQPIG 776
Cdd:TIGR01063 25 RALPDVRDGLKPVHRRILYAMYElglTPDKPYKKSARIVGDV--MGKYHpHGDSAIYDTLVRMAQDF--SLRYPLVDGQG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 777 QFGTRlhGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFL--YDDNQRvEPEWYIPIIPMVLINGAEGIGTGWSCKIPN 854
Cdd:TIGR01063 101 NFGSI--DGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVpnYDGSEQ-EPTVLPSRFPNLLVNGSSGIAVGMATNIPP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 855 FDVREIVNNIRRLMDGEE----------PLPMLP-------------SYKNFKGTIeelapnqyVISGEVAILNS----T 907
Cdd:TIGR01063 178 HNLGEIIDALLAYIDNPDisiqelleviKGPDFPtggiilgrsgirsAYETGRGSI--------VIRARAEIEEDskgrE 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 908 TIEISELPVRTWTQTYKEQVLEpMLNgtEKTPPLITDYREYHTDTTVKFVVkmtEEKLAEAERVGLHKVFK---LQTSLT 984
Cdd:TIGR01063 250 AIIVTEIPYQVNKARLIEKIAE-LVR--EKKIEGISDIRDESDREGIRIVI---ELKRDAVAEVVLNNLYKqtqLQVSFG 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 985 CNSMVLFDHvgcLKKYDTVLDILRDFFELRLK------YYGLRK-----EWLLGMLGAesakLNNqarfilekIDGKI-I 1052
Cdd:TIGR01063 324 INMLALVKG---LPKVLNLKELLEAFVEHRKDvitrrtIFELRKaeeraHILEGLLIA----LDN--------IDEVIaL 388
|
410 420
....*....|....*....|....*
gi 530412779 1053 IENKPKKELIKVLIQRGYDSDPVKA 1077
Cdd:TIGR01063 389 IRASQNTEEAKTRLVERFSLSEIQA 413
|
|
| gyrB |
PRK14939 |
DNA gyrase subunit B; Provisional |
93-574 |
1.43e-18 |
|
DNA gyrase subunit B; Provisional
Pssm-ID: 237860 [Multi-domain] Cd Length: 756 Bit Score: 92.08 E-value: 1.43e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 93 IRVTIDPENNlISIWNNGKGIPVVEHKVEKmyVPAL--IFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVeTA 170
Cdd:PRK14939 61 ITVTIHADGS-VSVSDNGRGIPTDIHPEEG--VSAAevIMTVLHAGGKFDQNSYKVSGGLHGVGVSVVNALSEWLEL-TI 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 171 SREyKKMFKQTWmdNMGRA-------GEMELKpfnGedyTCITFQPDLSKFKMQSLDKDIVAlmvRRAYDIAgstkdvkv 243
Cdd:PRK14939 137 RRD-GKIHEQEF--EHGVPvaplkvvGETDKT---G---TEVRFWPSPEIFENTEFDYDILA---KRLRELA-------- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 244 FLNgnklpvkgfrSYVDMYLKDKLDETGNSL-----------------KVIHEQVNH--------RWEVCL----TMSEK 294
Cdd:PRK14939 197 FLN----------SGVRIRLKDERDGKEEEFhyeggikafveylnrnkTPLHPNIFYfsgekdgiGVEVALqwndSYQEN 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 295 GFqqiSFVNSIATSKGGRHV------------DYVADQIVTKlvdvvKKKNK--------GGVAVKAhqVKnhmwifvna 354
Cdd:PRK14939 267 VL---CFTNNIPQRDGGTHLagfraaltrtinNYIEKEGLAK-----KAKVSltgddareGLTAVLS--VK--------- 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 355 lIENPTFDSQTKENMtlqpksfGStcqlSEkfIKaaigcGIVESILN--WVKF------KAQVQLNKKCSAVKH------ 420
Cdd:PRK14939 328 -VPDPKFSSQTKDKL-------VS----SE--VR-----PAVESLVNekLSEFleenpnEAKIIVGKIIDAARAreaark 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 421 ----NRIKGIpkLDDAN------DAGGRNSTECTLILTEGDSA----KTlavsglgvvGRD-KY-GVFPLRGKILNVREA 484
Cdd:PRK14939 389 arelTRRKGA--LDIAGlpgklaDCQEKDPALSELYLVEGDSAggsaKQ---------GRDrKFqAILPLKGKILNVEKA 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 485 SHKQIMENAEINNIIKIVGLQYKKnyeDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLeeFI-- 562
Cdd:PRK14939 458 RFDKMLSSQEIGTLITALGCGIGR---DEFNPDKLRYHKIIIMTDADVDGSHIRTLLLTFFYRQMPELIERGHL--YIaq 532
|
570
....*....|..
gi 530412779 563 TPIVKVSKNKQE 574
Cdd:PRK14939 533 PPLYKVKKGKQE 544
|
|
| PRK09630 |
PRK09630 |
DNA topoisomerase IV subunit A; Provisional |
700-922 |
2.09e-17 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 170022 Cd Length: 479 Bit Score: 87.26 E-value: 2.09e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 700 ERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVaeMSSYHHGEMSLMMTIINLAqnfvgsNNLNLLQPIGQFG 779
Cdd:PRK09630 22 ERAIPHILDGLKPVQRRLLWTLFRMDDGKMHKVANIAGRT--MALHPHGDAPIVEALVVLA------NKGYLIDTQGNFG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 780 TRLHGGKDSASpRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRvEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVRE 859
Cdd:PRK09630 94 NPLTGDPHAAA-RYIEARLSPLAKEVLFNTDLMTFHDSYDGREK-EPDILPAKLPLLLLHGVDGIAVGMTTKIFPHNFCE 171
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530412779 860 IVN-NIRRLMDgeEPLPMLPSYKNfKGTIEelaPNQY-------VISGEVAILNSTTIEISELPVRTWTQT 922
Cdd:PRK09630 172 LLEaQIAILND--QPFTLLPDFPS-GGTMD---ASEYqdglgsiTLRASIDIINDKTLLIKEICPSTTTET 236
|
|
| PRK12758 |
PRK12758 |
DNA gyrase/topoisomerase IV subunit A; |
700-852 |
2.04e-12 |
|
DNA gyrase/topoisomerase IV subunit A;
Pssm-ID: 237192 [Multi-domain] Cd Length: 869 Bit Score: 72.34 E-value: 2.04e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 700 ERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEmssYH-HGEMSLMMTIINLAQnfvgsNNLnLLQPIGQF 778
Cdd:PRK12758 41 ERAVPHIEDGLKPVQRRILHSMKEMDDGRYNKVANVVGHTMQ---YHpHGDASIGDALVQLGQ-----KDL-LIDTQGNW 111
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530412779 779 GTRLhGGKDSASPRYIFTMLSSLA-RLLFPPKDDHtLKFLYDDNQRvEPEwYIPI-IPMVLINGAEGIGTGWSCKI 852
Cdd:PRK12758 112 GNIL-TGDGAAAPRYIEARLSKFAlEVVFNPKTTE-WQLSYDGRKK-EPV-TLPVkFPLLLAQGAEGIAVGLSTKI 183
|
|
| TopoII_MutL_Trans |
cd00329 |
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the ... |
255-367 |
2.82e-11 |
|
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes. The GyrB dimerizes in response to ATP binding, and is homologous to the N-terminal half of eukaryotic Topo II and the ATPase fragment of MutL. Type II DNA topoisomerases catalyze the ATP-dependent transport of one DNA duplex through another, in the process generating transient double strand breaks via covalent attachments to both DNA strands at the 5' positions. Included in this group are proteins similar to human MLH1 and PMS2. MLH1 forms a heterodimer with PMS2 which functions in meiosis and in DNA mismatch repair (MMR). Cells lacking either hMLH1 or hPMS2 have a strong mutator phenotype and display microsatellite instability (MSI). Mutation in hMLH1 accounts for a large fraction of Lynch syndrome (HNPCC) families.
Pssm-ID: 238202 [Multi-domain] Cd Length: 107 Bit Score: 61.89 E-value: 2.82e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 255 FRSYVDMYLKDKLDEtgnslKVIHEQVNH---RWEVCLTMSE----KGFQQISFVNSIATSKGGRHVDYVADQIVTKLvd 327
Cdd:cd00329 1 LKDRLAEILGDKVAD-----KLIYVEGESdgfRVEGAISYPDsgrsSKDRQFSFVNGRPVREGGTHVKAVREAYTRAL-- 73
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 530412779 328 vvkkknkggvavKAHQVKNHMWIFVNALIEN--PTFD-SQTKE 367
Cdd:cd00329 74 ------------NGDDVRRYPVAVLSLKIPPslVDVNvHPTKE 104
|
|
| HATPase_GyrB-like |
cd16928 |
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes ... |
69-246 |
1.75e-10 |
|
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes histidine kinase-like ATPase domain of the B subunit of DNA gyrase. Bacterial DNA gyrase is a type II topoisomerase (type II as it transiently cleaves both strands of DNA) which catalyzes the introduction of negative supercoils into DNA, possibly by a mechanism in which one segment of the double-stranded DNA substrate is passed through a transient break in a second segment. It consists of GyrA and GyrB subunits in an A2B2 stoichiometry; GyrA subunits catalyze strand-breakage and reunion reactions, and GyrB subunits hydrolyze ATP. DNA gyrase is found in bacteria, plants and archaea, but as it is absent in humans it is a possible drug target for the treatment of bacterial and parasite infections.
Pssm-ID: 340405 [Multi-domain] Cd Length: 180 Bit Score: 61.40 E-value: 1.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 69 LYKIFDEILVNAAD-------NKqrdpkmscIRVTIDpENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDD 141
Cdd:cd16928 1 LHHLVWEIVDNSIDealagyaTE--------IEVTLH-EDNSITVEDNGRGIPVDIHPKTGKSAVEVVLTVLHAGGKFDG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 142 DEKKVTGGRNGYGAKLCNIFSTKFTVETAsREyKKMFKQTWMDNmGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDK 221
Cdd:cd16928 72 GSYKVSGGLHGVGVSVVNALSERLEVEVK-RD-GKIYRQEFSRG-GPLTPLEVIGETKKTGTTVRFWPDPEIFEKTEFDF 148
|
170 180
....*....|....*....|....*
gi 530412779 222 DIVAlmvRRAYDIAGSTKDVKVFLN 246
Cdd:cd16928 149 DTLK---RRLRELAFLNKGLKIVLE 170
|
|
| PRK05561 |
PRK05561 |
DNA topoisomerase 4 subunit A; |
700-946 |
2.40e-10 |
|
DNA topoisomerase 4 subunit A;
Pssm-ID: 235503 [Multi-domain] Cd Length: 742 Bit Score: 65.51 E-value: 2.40e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 700 ERSIPSMVDGLKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFvgSNNLNLLQPI 775
Cdd:PRK05561 33 DRALPDVRDGLKPVQRRILYAMSElglTPDAKFKKSARVVGDV--LGKYHpHGDSSIYDAMVRMAQDF--SYRYPLVDGQ 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 776 GQFGTRlhGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFL--YDDNQRvEPEWYIPIIPMVLINGAEGIGTGWSCKIP 853
Cdd:PRK05561 109 GNFGSI--DGDPAAAMRYTEARLSPIAELLLEEIDEGTVDFVpnFDGTLK-EPTVLPARFPNLLLNGATGIAVGMATDIP 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 854 NFDVREIVNNIRRLMDGEE----------PLPMLPS--------------YKNFKG--------TIEELAPNQYVisgev 901
Cdd:PRK05561 186 PHNLREVIDAAIHLIDNPDatleelmefvPGPDFPTggeiitgrdgirkaYETGRGsirvrarwEIEDLAGGRWQ----- 260
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 530412779 902 ailnsttIEISELPVrtwtQTYKEQVLEPMLNGT-EKTPPLITDYR 946
Cdd:PRK05561 261 -------IVITELPY----QVSKAKLIEQIAELMnAKKLPGIADVR 295
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
68-175 |
3.15e-08 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 53.14 E-value: 3.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 68 GLYKIFDEILVNAADNKqrdPKMSCIRVTIDPENNL-ISIWNNGKGIPVVEHKvekmyvpaLIFGQLLTSSnydddekKV 146
Cdd:pfam02518 5 RLRQVLSNLLDNALKHA---AKAGEITVTLSEGGELtLTVEDNGIGIPPEDLP--------RIFEPFSTAD-------KR 66
|
90 100 110
....*....|....*....|....*....|.
gi 530412779 147 TGGRNGYGAKLCNIFSTKF--TVETASREYK 175
Cdd:pfam02518 67 GGGGTGLGLSIVRKLVELLggTITVESEPGG 97
|
|
| PRK13979 |
PRK13979 |
DNA topoisomerase IV subunit A; Provisional |
700-872 |
4.92e-08 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 237576 [Multi-domain] Cd Length: 957 Bit Score: 57.81 E-value: 4.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 700 ERSIPSMVDGLKPGQRKVLFTCFKRN---DKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFvgSNNLNLLQPI 775
Cdd:PRK13979 36 DRALPDVRDGLKPVHRRILYGAYMLKafpDKPYYKSARIVGDI--LGKYHpHGDSSVYDAMVILAQDF--TTRMPLIDGH 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 776 GQFGTRlhGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFL--YDDNQRvEPEWYIPIIPMVLINGAEGIGTGWSCKIP 853
Cdd:PRK13979 112 GNWGSI--DGDSAAAMRYTEARLTPIAMEMLRDIDKDVVNMVdnYSDSEK-EPEVLPARYPNLLVNGAFGIAVGLATNIP 188
|
170
....*....|....*....
gi 530412779 854 NFDVREIVNNIRRLMDGEE 872
Cdd:PRK13979 189 PHNLKEVIDGTLAYIDNNE 207
|
|
| GyrA |
COG0188 |
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair]; |
701-869 |
1.87e-07 |
|
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
Pssm-ID: 439958 [Multi-domain] Cd Length: 804 Bit Score: 55.82 E-value: 1.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 701 RSIPSMVDGLKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFvgSNNLNLLQPIG 776
Cdd:COG0188 34 RALPDVRDGLKPVHRRILYAMHElglTPDKPYKKSARVVGDV--MGKYHpHGDSAVYDALVRMAQDF--SMRYPLVDGQG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 777 QFGTRlhGGkDS-ASPRYIFTMLSSLARLLFPPKDDHTLKFL--YDDNQRvEPEwYIP-IIPMVLINGAEGIGTGWSCKI 852
Cdd:COG0188 110 NFGSI--DG-DPaAAMRYTEARLAKIAEELLADIDKDTVDFVpnYDGSEQ-EPT-VLPaRFPNLLVNGSSGIAVGMATNI 184
|
170
....*....|....*....
gi 530412779 853 P--NfdVREIVNNIRRLMD 869
Cdd:COG0188 185 PphN--LGEVIDACIALID 201
|
|
| PRK05560 |
PRK05560 |
DNA gyrase subunit A; Validated |
701-890 |
2.62e-07 |
|
DNA gyrase subunit A; Validated
Pssm-ID: 235502 [Multi-domain] Cd Length: 805 Bit Score: 55.42 E-value: 2.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 701 RSIPSMVDGLKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFvgSNNLNLLQPIG 776
Cdd:PRK05560 29 RALPDVRDGLKPVHRRILYAMNElgnTPDKPYKKSARIVGDV--MGKYHpHGDSAVYDALVRMAQDF--SMRYPLVDGQG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 777 QFGTRlhGGkDS-ASPRYIFTMLSSLARLLFPPKDDHTLKFL--YDDNQRvEPEwYIPI-IPMVLINGAEGIGTGWSCKI 852
Cdd:PRK05560 105 NFGSI--DG-DPaAAMRYTEARMSKIAHELLADIDKETVDFVpnYDGSEQ-EPT-VLPArFPNLLVNGSSGIAVGMATNI 179
|
170 180 190
....*....|....*....|....*....|....*...
gi 530412779 853 PNFDVREIVNNIRRLMDGEEplpmlpsyknfkGTIEEL 890
Cdd:PRK05560 180 PPHNLGEVIDACLALIDNPD------------ITIEEL 205
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
68-168 |
1.44e-06 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 48.41 E-value: 1.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 68 GLYKIFDEILVNAADNKqrdPKMSCIRVTIDPENN--LISIWNNGKGIPvvEHKVEKMYVPaliFGQLltssnyddDEKK 145
Cdd:smart00387 5 RLRQVLSNLLDNAIKYT---PEGGRITVTLERDGDhvEITVEDNGPGIP--PEDLEKIFEP---FFRT--------DKRS 68
|
90 100
....*....|....*....|...
gi 530412779 146 VTGGRNGYGAKLCNIFSTKFTVE 168
Cdd:smart00387 69 RKIGGTGLGLSIVKKLVELHGGE 91
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
444-544 |
1.64e-06 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 47.74 E-value: 1.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 444 TLILTEGDS-AKTLAvsglGVVGRDKYGVFPLRGKILNVREASHKQIMenaeinNIIKIVGLQYKKnyededslktlryg 522
Cdd:pfam01751 1 ELIIVEGPSdAIALE----KALGGGFQAVVAVLGHLLSLEKGPKKKAL------KALKELALKAKE-------------- 56
|
90 100
....*....|....*....|..
gi 530412779 523 kIMIMTDQDQDGSHIKGLLINF 544
Cdd:pfam01751 57 -VILATDPDREGEAIALKLLEL 77
|
|
| TOPRIM |
cd00188 |
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type ... |
443-554 |
5.87e-04 |
|
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from bacterial and archaea, and bacterial DNA repair proteins of the RecR/M family. This domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in nucleotide polymerization by primases and in strand joining in topoisomerases and, as a general acid in strand cleavage by topisomerases and nucleases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173773 [Multi-domain] Cd Length: 83 Bit Score: 40.10 E-value: 5.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412779 443 CTLILTEGDS-AKTLAVSGlgvvgRDKYGVFPLRGKILNvreashkqimenAEINNIIKIVGlqykknyededslktlRY 521
Cdd:cd00188 1 KKLIIVEGPSdALALAQAG-----GYGGAVVALGGHALN------------KTRELLKRLLG----------------EA 47
|
90 100 110
....*....|....*....|....*....|...
gi 530412779 522 GKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR 554
Cdd:cd00188 48 KEVIIATDADREGEAIALRLLELLKSLGKKVRR 80
|
|
| |
