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Conserved domains on  [gi|530393892|ref|XP_005269986|]
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non-structural maintenance of chromosomes element 4 homolog A isoform X2 [Homo sapiens]

Protein Classification

non-structural maintenance of chromosomes element 4( domain architecture ID 10555400)

non-structural maintenance of chromosomes element 4 is a component of the SMC5-SMC6 complex, which promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nse4_C pfam08743
Nse4 C-terminal; Nse4 is the kleisin component of the Smc5/6 DNA repair complex. It bridges ...
 126-215 1.14e-35

Nse4 C-terminal; Nse4 is the kleisin component of the Smc5/6 DNA repair complex. It bridges the heads of Smc5 and Smc6. This is the C-terminal domain of Nse4 that interacts with the head domain of Smc5.


:

Pssm-ID: 462585  Cd Length: 89  Bit Score: 121.09  E-value: 1.14e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393892  126 PMSFFDFVVDPHSFPRTVENIFHVSFIIRDGFARIRLDQDRLPVIEPVSINEENEGFEHNTQvRNQGIIALSYRDWEEIV 205
Cdd:pfam08743   1 PINLFKFVINPKSFAQTVENLFYLSFLVKDGRVGIELDEDGLPVLEPVAPPEEEEAKEGGVS-RNQAVFSLDMKTWKELI 79

                          90
                  ....*....|
gi 530393892  206 KTFEISEPVI 215
Cdd:pfam08743  80 EAFDITEPMI 89
 
Name Accession Description Interval E-value
Nse4_C pfam08743
Nse4 C-terminal; Nse4 is the kleisin component of the Smc5/6 DNA repair complex. It bridges ...
 126-215 1.14e-35

Nse4 C-terminal; Nse4 is the kleisin component of the Smc5/6 DNA repair complex. It bridges the heads of Smc5 and Smc6. This is the C-terminal domain of Nse4 that interacts with the head domain of Smc5.


Pssm-ID: 462585  Cd Length: 89  Bit Score: 121.09  E-value: 1.14e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393892  126 PMSFFDFVVDPHSFPRTVENIFHVSFIIRDGFARIRLDQDRLPVIEPVSINEENEGFEHNTQvRNQGIIALSYRDWEEIV 205
Cdd:pfam08743   1 PINLFKFVINPKSFAQTVENLFYLSFLVKDGRVGIELDEDGLPVLEPVAPPEEEEAKEGGVS-RNQAVFSLDMKTWKELI 79

                          90
                  ....*....|
gi 530393892  206 KTFEISEPVI 215
Cdd:pfam08743  80 EAFDITEPMI 89
COG5125 COG5125
Uncharacterized conserved protein [Function unknown];
72-215 1.13e-14

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 227454 [Multi-domain]  Cd Length: 259  Bit Score: 70.80  E-value: 1.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393892  72 PRVDRPRKVPVIQEERAMPAQLRRMEESHQEATEKEVERILGLLQtyfredPDTPMSFFDFVVDPHSFPRTVENIFHVSF 151
Cdd:COG5125  130 PSRRRAQSQRSRQTLPETEVPTNITRQEDSVEEPKILAQISRLLA------EKGRTNYFKFIIDPRSFSKTIENLFYLSF 203

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530393892 152 IIRDGFARIRLDQDRLPVIEPVSIneenegFEHNTqvrNQGIIALSYRDWEEIVKTFEISEPVI 215
Cdd:COG5125  204 LLKEGKAFLEFDEDGTLYVVSEGS------EGAST---GHLVVEMTYDEYLRIVERMGISKAMI 258
 
Name Accession Description Interval E-value
Nse4_C pfam08743
Nse4 C-terminal; Nse4 is the kleisin component of the Smc5/6 DNA repair complex. It bridges ...
 126-215 1.14e-35

Nse4 C-terminal; Nse4 is the kleisin component of the Smc5/6 DNA repair complex. It bridges the heads of Smc5 and Smc6. This is the C-terminal domain of Nse4 that interacts with the head domain of Smc5.


Pssm-ID: 462585  Cd Length: 89  Bit Score: 121.09  E-value: 1.14e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393892  126 PMSFFDFVVDPHSFPRTVENIFHVSFIIRDGFARIRLDQDRLPVIEPVSINEENEGFEHNTQvRNQGIIALSYRDWEEIV 205
Cdd:pfam08743   1 PINLFKFVINPKSFAQTVENLFYLSFLVKDGRVGIELDEDGLPVLEPVAPPEEEEAKEGGVS-RNQAVFSLDMKTWKELI 79

                          90
                  ....*....|
gi 530393892  206 KTFEISEPVI 215
Cdd:pfam08743  80 EAFDITEPMI 89
COG5125 COG5125
Uncharacterized conserved protein [Function unknown];
72-215 1.13e-14

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 227454 [Multi-domain]  Cd Length: 259  Bit Score: 70.80  E-value: 1.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530393892  72 PRVDRPRKVPVIQEERAMPAQLRRMEESHQEATEKEVERILGLLQtyfredPDTPMSFFDFVVDPHSFPRTVENIFHVSF 151
Cdd:COG5125  130 PSRRRAQSQRSRQTLPETEVPTNITRQEDSVEEPKILAQISRLLA------EKGRTNYFKFIIDPRSFSKTIENLFYLSF 203

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530393892 152 IIRDGFARIRLDQDRLPVIEPVSIneenegFEHNTqvrNQGIIALSYRDWEEIVKTFEISEPVI 215
Cdd:COG5125  204 LLKEGKAFLEFDEDGTLYVVSEGS------EGAST---GHLVVEMTYDEYLRIVERMGISKAMI 258
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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