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Conserved domains on  [gi|530362302|ref|XP_005270768|]
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importin subunit alpha-7 isoform X1 [Homo sapiens]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
66-555 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 621.91  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302  66 IQLRKQKREQQLFKRRNVELINEEAamfdsllMDSYVSSTTGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPP 145
Cdd:COG5064   34 VELRKQKREELLNKRRNLADVSEEA-------ESSFIPMEQQFYSELPQLTQQLFSDDIEQQLQAVYKFRKLLSKETSPP 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302 146 IDEVINTPrVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIA 225
Cdd:COG5064  107 IQPVIDAG-VVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWALGNIA 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302 226 GDSSVCRDYVLNCSILNPLLTLLTKSTR-LTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACW 304
Cdd:COG5064  186 GDSEGCRDYVLQCGALEPLLGLLLSSAIhISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVLVDACW 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302 305 ALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRK 384
Cdd:COG5064  266 AISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIRK 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302 385 EACWTISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGT--PEQIRYLVSLGCIKPLCDLLTV 462
Cdd:COG5064  346 EACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLnrPDIIRYLVSQGFIKPLCDLLDV 425

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302 463 MDSKIVQVALNGLENILRLGEQEGKRSGSGVNPYCGLIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEDDDSSLA 542
Cdd:COG5064  426 VDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMDAIHGLQDSVNRTIYDKAYSIIEKFFGEEDAVDELA 505

                        490       500
                 ....*....|....*....|.
gi 530362302 543 PQV--------DETQQQFIFQ 555
Cdd:COG5064  506 PETagntftfgSNVNQQGNFN 526
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
66-555 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 621.91  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302  66 IQLRKQKREQQLFKRRNVELINEEAamfdsllMDSYVSSTTGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPP 145
Cdd:COG5064   34 VELRKQKREELLNKRRNLADVSEEA-------ESSFIPMEQQFYSELPQLTQQLFSDDIEQQLQAVYKFRKLLSKETSPP 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302 146 IDEVINTPrVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIA 225
Cdd:COG5064  107 IQPVIDAG-VVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWALGNIA 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302 226 GDSSVCRDYVLNCSILNPLLTLLTKSTR-LTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACW 304
Cdd:COG5064  186 GDSEGCRDYVLQCGALEPLLGLLLSSAIhISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVLVDACW 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302 305 ALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRK 384
Cdd:COG5064  266 AISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIRK 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302 385 EACWTISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGT--PEQIRYLVSLGCIKPLCDLLTV 462
Cdd:COG5064  346 EACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLnrPDIIRYLVSQGFIKPLCDLLDV 425

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302 463 MDSKIVQVALNGLENILRLGEQEGKRSGSGVNPYCGLIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEDDDSSLA 542
Cdd:COG5064  426 VDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMDAIHGLQDSVNRTIYDKAYSIIEKFFGEEDAVDELA 505

                        490       500
                 ....*....|....*....|.
gi 530362302 543 PQV--------DETQQQFIFQ 555
Cdd:COG5064  506 PETagntftfgSNVNQQGNFN 526
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 499-544 1.83e-19

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 81.87  E-value: 1.83e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 530362302  499 LIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVED--DDSSLAPQ 544
Cdd:pfam16186   2 LIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEeeDDENLAPE 49
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 186-225 7.31e-10

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 54.36  E-value: 7.31e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 530362302   186 TSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIA 225
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 113-267 7.13e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 39.32  E-value: 7.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302  113 REMVEMLFSDDSDLQ------LATTQKFRKLLSKepSPPIDEVINTprvvdrfVEFLKRNENCTLQFEAAWALTNIASGT 186
Cdd:PLN03200  612 RTLIQLLSSSKEETQekaasvLADIFSSRQDLCE--SLATDEIINP-------CIKLLTNNTEAVATQSARALAALSRSI 682

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302  187 SQQTKI-VIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDyVLNCSILNPLLTLLTKSTrLTMTRNAVWALS 265
Cdd:PLN03200  683 KENRKVsYAAEDAIKPLIKLAKSSSIEVAEQAVCALANLLSDPEVAAE-ALAEDIILPLTRVLREGT-LEGKRNAARALA 760


                  ..
gi 530362302  266 NL 267
Cdd:PLN03200  761 QL 762
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
66-555 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 621.91  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302  66 IQLRKQKREQQLFKRRNVELINEEAamfdsllMDSYVSSTTGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPP 145
Cdd:COG5064   34 VELRKQKREELLNKRRNLADVSEEA-------ESSFIPMEQQFYSELPQLTQQLFSDDIEQQLQAVYKFRKLLSKETSPP 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302 146 IDEVINTPrVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIA 225
Cdd:COG5064  107 IQPVIDAG-VVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWALGNIA 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302 226 GDSSVCRDYVLNCSILNPLLTLLTKSTR-LTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACW 304
Cdd:COG5064  186 GDSEGCRDYVLQCGALEPLLGLLLSSAIhISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVLVDACW 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302 305 ALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRK 384
Cdd:COG5064  266 AISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIRK 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302 385 EACWTISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGT--PEQIRYLVSLGCIKPLCDLLTV 462
Cdd:COG5064  346 EACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLnrPDIIRYLVSQGFIKPLCDLLDV 425

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302 463 MDSKIVQVALNGLENILRLGEQEGKRSGSGVNPYCGLIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEDDDSSLA 542
Cdd:COG5064  426 VDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMDAIHGLQDSVNRTIYDKAYSIIEKFFGEEDAVDELA 505

                        490       500
                 ....*....|....*....|.
gi 530362302 543 PQV--------DETQQQFIFQ 555
Cdd:COG5064  506 PETagntftfgSNVNQQGNFN 526
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 499-544 1.83e-19

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 81.87  E-value: 1.83e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 530362302  499 LIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVED--DDSSLAPQ 544
Cdd:pfam16186   2 LIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEeeDDENLAPE 49
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 43-132 3.22e-18

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 79.12  E-value: 3.22e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302   43 RMKSYKNNALNPEEMRRRREEEGIQLRKQKREQQLFKRRNVELINEEAAMFDSLLmdsyvssttgeSVITREMVEMLFSD 122
Cdd:pfam01749   1 RRKSFKNKGKDADELRRRREEVQVELRKQKREEQLLKRRNVGAPSSSSSSAESQL-----------LESLPEMVQGVNSD 69

                          90
                  ....*....|
gi 530362302  123 DSDLQLATTQ 132
Cdd:pfam01749  70 DPELQLEATQ 79
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 186-225 1.31e-11

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 59.39  E-value: 1.31e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 530362302  186 TSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIA 225
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
HEAT COG1413
HEAT repeat [General function prediction only];
258-432 4.21e-11

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 60.80  E-value: 4.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302 258 RNAVWALSNLcrgknpppefaKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDgpnekIQAVidsgvcRRLVELLMHND 337
Cdd:COG1413    3 RAAARALGRL-----------GDPAAVPALIAALADEDPDVRAAAARALGRLGD-----PRAV------PALLEALKDPD 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302 338 YKVASPALRAVGNIvtGDDiqtqvilncSALPCLLHLLSSPKESIRKEACWTISNITagnraqiqaviDANIFPVLIEIL 417
Cdd:COG1413   61 PEVRAAAAEALGRI--GDP---------EAVPALIAALKDEDPEVRRAAAEALGRLG-----------DPAAVPALLEAL 118

                        170
                 ....*....|....*
gi 530362302 418 QKAEFRTRKEAAWAI 432
Cdd:COG1413  119 KDPDWEVRRAAARAL 133
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 358-395 4.20e-10

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 55.15  E-value: 4.20e-10
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 530362302  358 QTQVILNCSALPCLLHLLSSPKESIRKEACWTISNITA 395
Cdd:pfam00514   4 NKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 186-225 7.31e-10

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 54.36  E-value: 7.31e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 530362302   186 TSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIA 225
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
HEAT COG1413
HEAT repeat [General function prediction only];
175-351 1.96e-09

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 56.18  E-value: 1.96e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302 175 AAWALTNIASgtsqqtkivieAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVcrdyvlncsilNPLLTLLtKSTRL 254
Cdd:COG1413    5 AARALGRLGD-----------PAAVPALIAALADEDPDVRAAAARALGRLGDPRAV-----------PALLEAL-KDPDP 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302 255 TMTRNAVWALSNLcrgKNPPPefakvspcLPVLSRLLFSSDSDLLADACWALSYLSDgpnekiQAVIDsgvcrRLVELLM 334
Cdd:COG1413   62 EVRAAAAEALGRI---GDPEA--------VPALIAALKDEDPEVRRAAAEALGRLGD------PAAVP-----ALLEALK 119

                        170
                 ....*....|....*..
gi 530362302 335 HNDYKVASPALRAVGNI 351
Cdd:COG1413  120 DPDWEVRRAAARALGRL 136
HEAT COG1413
HEAT repeat [General function prediction only];
213-393 1.46e-08

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 53.48  E-value: 1.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302 213 VQEQAVWALGNIAGDSSVcrdyvlncsilnPLLTLLTKSTRLTMTRNAVWALSNLcrgknpppefaKVSPCLPVLSRLLF 292
Cdd:COG1413    1 VRRAAARALGRLGDPAAV------------PALIAALADEDPDVRAAAARALGRL-----------GDPRAVPALLEALK 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302 293 SSDSDLLADACWALSYLSDgpnekiQAVIDsgvcrRLVELLMHNDYKVASPALRAVGNIvtGDDiqtqvilncSALPCLL 372
Cdd:COG1413   58 DPDPEVRAAAAEALGRIGD------PEAVP-----ALIAALKDEDPEVRRAAAEALGRL--GDP---------AAVPALL 115

                        170       180
                 ....*....|....*....|.
gi 530362302 373 HLLSSPKESIRKEACWTISNI 393
Cdd:COG1413  116 EALKDPDWEVRRAAARALGRL 136
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 355-395 3.81e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 49.35  E-value: 3.81e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 530362302   355 DDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTISNITA 395
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 171-224 5.41e-08

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 49.29  E-value: 5.41e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 530362302  171 LQFEAAWALTNIASGTSQQTKIVIEAgAVPIFIELLNSDFEDVQEQAVWALGNI 224
Cdd:pfam13513   3 VREAAALALGSLAEGGPDLLAPAVPE-LLPALLPLLNDDSDLVREAAAWALGRL 55
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 397-437 1.20e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.83  E-value: 1.20e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 530362302  397 NRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATS 437
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 313-353 6.49e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.91  E-value: 6.49e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 530362302  313 PNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVT 353
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 440-480 9.51e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.52  E-value: 9.51e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 530362302  440 TPEQIRYLVSLGCIKPLCDLLTVMDSKIVQVALNGLENILR 480
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 228-269 1.04e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.52  E-value: 1.04e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 530362302  228 SSVCRDYVLNCSILNPLLTLLtKSTRLTMTRNAVWALSNLCR 269
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLL-SSPDEEVQEEAAWALSNLAA 41
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 156-265 5.67e-06

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 44.64  E-value: 5.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302  156 VDRFVEFLKRNENCTLQFEAAWALTNIASgtsqqtkivieAGAVPIFIELLNSDFEDVQEQAVWALGNIaGDSSVcrdyv 235
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRALGRIGD-----------PEAVPALLELLKDEDPAVRRAAAEALGKI-GDPEA----- 63

                          90       100       110
                  ....*....|....*....|....*....|
gi 530362302  236 lncsiLNPLLTLLTKSTRLTMTRNAVWALS 265
Cdd:pfam13646  64 -----LPALLELLRDDDDDVVRAAAAEALA 88
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 313-352 7.30e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 42.80  E-value: 7.30e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 530362302   313 PNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIV 352
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 397-437 1.91e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 41.65  E-value: 1.91e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 530362302   397 NRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATS 437
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 272-311 2.22e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 41.67  E-value: 2.22e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 530362302  272 NPPPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSD 311
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT COG1413
HEAT repeat [General function prediction only];
150-225 3.76e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 43.85  E-value: 3.76e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530362302 150 INTPRVVDRFVEFLKrNENCTLQFEAAWALTNIASgtsqqtkivieAGAVPIFIELLNSDFEDVQEQAVWALGNIA 225
Cdd:COG1413   74 IGDPEAVPALIAALK-DEDPEVRRAAAEALGRLGD-----------PAAVPALLEALKDPDWEVRRAAARALGRLG 137
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 344-393 9.03e-05

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 40.43  E-value: 9.03e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 530362302  344 ALRAVGNI--VTGDDIQTQVIlncSALPCLLHLLSSPKESIRKEACWTISNI 393
Cdd:pfam13513   7 AALALGSLaeGGPDLLAPAVP---ELLPALLPLLNDDSDLVREAAAWALGRL 55
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 440-478 1.40e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.33  E-value: 1.40e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 530362302   440 TPEQIRYLVSLGCIKPLCDLLTVMDSKIVQVALNGLENI 478
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNL 39
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 142-184 2.49e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 38.59  E-value: 2.49e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 530362302  142 PSPPIDEVINtPRVVDRFVEFLKrNENCTLQFEAAWALTNIAS 184
Cdd:pfam00514   1 SPENKQAVIE-AGAVPPLVRLLS-SPDEEVQEEAAWALSNLAA 41
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 213-267 2.26e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 36.58  E-value: 2.26e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 530362302  213 VQEQAVWALGNIA-GDSSVCRDYVLNcsILNPLLTLLTKSTRLTMtRNAVWALSNL 267
Cdd:pfam13513   3 VREAAALALGSLAeGGPDLLAPAVPE--LLPALLPLLNDDSDLVR-EAAAWALGRL 55
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 329-429 3.14e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 36.93  E-value: 3.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302  329 LVELLM-HNDYKVASPALRAVGNIvtGDDiqtqvilncSALPCLLHLLSSPKESIRKEACWTISNItaGNRAQIqavida 407
Cdd:pfam13646   4 LLQALLrDPDPEVRAAAIRALGRI--GDP---------EAVPALLELLKDEDPAVRRAAAEALGKI--GDPEAL------ 64

                          90       100
                  ....*....|....*....|..
gi 530362302  408 nifPVLIEILQKAEFRTRKEAA 429
Cdd:pfam13646  65 ---PALLELLRDDDDDVVRAAA 83
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 113-267 7.13e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 39.32  E-value: 7.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302  113 REMVEMLFSDDSDLQ------LATTQKFRKLLSKepSPPIDEVINTprvvdrfVEFLKRNENCTLQFEAAWALTNIASGT 186
Cdd:PLN03200  612 RTLIQLLSSSKEETQekaasvLADIFSSRQDLCE--SLATDEIINP-------CIKLLTNNTEAVATQSARALAALSRSI 682

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302  187 SQQTKI-VIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDyVLNCSILNPLLTLLTKSTrLTMTRNAVWALS 265
Cdd:PLN03200  683 KENRKVsYAAEDAIKPLIKLAKSSSIEVAEQAVCALANLLSDPEVAAE-ALAEDIILPLTRVLREGT-LEGKRNAARALA 760


                  ..
gi 530362302  266 NL 267
Cdd:PLN03200  761 QL 762
HEAT COG1413
HEAT repeat [General function prediction only];
340-478 7.26e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 36.92  E-value: 7.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362302 340 VASPALRAVGNIvtGDDiqtqvilncSALPCLLHLLSSPKESIRKEACWTISNITagnraqiqaviDANIFPVLIEILQK 419
Cdd:COG1413    1 VRRAAARALGRL--GDP---------AAVPALIAALADEDPDVRAAAARALGRLG-----------DPRAVPALLEALKD 58

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530362302 420 AEFRTRKEAAWAITNAtsgGTPEQirylvslgcIKPLCDLLTVMDSKIVQVALNGLENI 478
Cdd:COG1413   59 PDPEVRAAAAEALGRI---GDPEA---------VPALIAALKDEDPEVRRAAAEALGRL 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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