|
Name |
Accession |
Description |
Interval |
E-value |
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
571-1227 |
2.84e-130 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 421.80 E-value: 2.84e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 571 QLPVFKHRASIVETLKRHRVVVVAGETGSGKSTQVPHFLLEdllLNDCGARKcnIVCTQPRRISAVSLATRVCEELGCEg 650
Cdd:COG1643 9 DLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLE---LGWGAGGR--IGMLEPRRLAARAAAERMAEELGEP- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 651 gPGGRnslCGYQIRMESRASESTRLLYCTTGVLLRKLQEDGLLADVSHVIVDEVHERSVQSDFLLVILKEILQK-RSDLH 729
Cdd:COG1643 83 -VGET---VGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPAlRPDLK 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 730 LILMSATVDSDKFSTYFTHCPILRISGRSYPVEVFHLediveetgfilekdseycqkfleeeeeitinvtskaggikkyq 809
Cdd:COG1643 159 LLVMSATLDAERFARLLGDAPVIESSGRTYPVEVRYR------------------------------------------- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 810 ecipvqsGASPELSPFYQkyssrtqyAVlymnphkinLDLILELLvyldkspqfRNIEGAVLIFLPGLAHIQQLYDLLsn 889
Cdd:COG1643 196 -------PLPADERDLED--------AV---------ADAVREAL---------AEEPGDILVFLPGEREIRRTAEAL-- 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 890 dRRFYSERYQLIALHSVLSTQDQAAAFMLPPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQMSSLVETF 969
Cdd:COG1643 241 -RGRLPPDTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTER 319
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 970 VSKASALQRQGRAGRVRDGFCFRLYTRERFEGFLEYSVPEILRVPLEELCLHiMKC-DLGSPEDFlsKALDPPQPQVISN 1048
Cdd:COG1643 320 ISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILE-LAAwGLGDPEDL--PFLDPPPARAIAD 396
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 1049 AMNLLRKIGACEPsEPKLTPLGQHLAALPVNVKIGKMLIFGAIFGCLEPVATLAAVMTEKSPFitpigRKDeadlakssl 1128
Cdd:COG1643 397 ARALLQELGALDA-DGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPR-----RGA--------- 461
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 1129 avADSDHLTIYNAYLGWKKAqqeggfrseisycQRNFLNRTSLLTLEDVKQELMKLVRaagfssstsweGKKGPQALSFQ 1208
Cdd:COG1643 462 --AGSDLLARLNLWRRLREQ-------------QREFLSYLRLREWRDLARQLRRLLG-----------EGANEEPADYE 515
|
650
....*....|....*....
gi 564335293 1209 DIALLkavLAAGLYDSVGK 1227
Cdd:COG1643 516 AIGLL---LALAYPDRIAR 531
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
572-754 |
2.40e-124 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 382.34 E-value: 2.40e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 572 LPVFKHRASIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNDCGARKCNIVCTQPRRISAVSLATRVCEELGCEGG 651
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEDLLLNGGTAQKCNIVCTQPRRISAMSLATRVCEELGCESG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 652 PGGRNSLCGYQIRMESRASESTRLLYCTTGVLLRKLQEDGLLADVSHVIVDEVHERSVQSDFLLVILKEILQKRSDLHLI 731
Cdd:cd17975 81 PGGKNSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHLI 160
|
170 180
....*....|....*....|...
gi 564335293 732 LMSATVDSDKFSTYFTHCPILRI 754
Cdd:cd17975 161 LMSATVDCEKFSSYFTHCPILRI 183
|
|
| DEAH_box_HrpA |
TIGR01967 |
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ... |
555-1218 |
1.96e-98 |
|
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273900 [Multi-domain] Cd Length: 1283 Bit Score: 343.67 E-value: 1.96e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 555 RLQSTPKyqrlLKERQQLPVFKHRASIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLlndcgARKCNIVCTQPRRIS 634
Cdd:TIGR01967 53 RRQAVPE----IRYPDNLPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICLELGR-----GSHGLIGHTQPRRLA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 635 AVSLATRVCEELGCEGGpggrnSLCGYQIRMESRASESTRLLYCTTGVLLRKLQEDGLLADVSHVIVDEVHERSVQSDFL 714
Cdd:TIGR01967 124 ARTVAQRIAEELGTPLG-----EKVGYKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFL 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 715 LVILKEILQKRSDLHLILMSATVDSDKFSTYFTHCPILRISGRSYPVEVFHlediveetgfilekdseycqKFLEEEEEI 794
Cdd:TIGR01967 199 LGYLKQLLPRRPDLKIIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRY--------------------RPLVEEQED 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 795 TinvtskaggikkyqecipvqsgaspelspfyqkysSRTQYAVLymnphkinLDLILELlvyldkspqFRNIEGAVLIFL 874
Cdd:TIGR01967 259 D-----------------------------------DLDQLEAI--------LDAVDEL---------FAEGPGDILIFL 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 875 PGLAHIQQLYDLLsndRRFYSERYQLIALHSVLSTQDQAAAFMlpPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKEN 954
Cdd:TIGR01967 287 PGEREIRDAAEIL---RKRNLRHTEILPLYARLSNKEQQRVFQ--PHSGRRIVLATNVAETSLTVPGIHYVIDTGTARIS 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 955 KYHESSQMSSLVETFVSKASALQRQGRAGRVRDGFCFRLYTRERFEGFLEYSVPEILRVPLEELCLHIMKCDLGSPEDFl 1034
Cdd:TIGR01967 362 RYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNSRPEFTDPEILRTNLASVILQMLALRLGDIAAF- 440
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 1035 sKALDPPQPQVISNAMNLLRKIGAC--EPSEPKLTPLGQHLAALPVNVKIGKMLIFGAIFGCLEPVATLAAVMTEKSPFI 1112
Cdd:TIGR01967 441 -PFIEAPDPRAIRDGFRLLEELGALddDEAEPQLTPIGRQLAQLPVDPRLARMLLEAHRLGCLQEVLIIASALSIQDPRE 519
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 1113 TPIGRKDEADLAKSSLAVADSDHLTIYNAYLGWKKAQQE---GGFRSEisyCQRNFLNRTSLLTLEDVKQELMKLVRAAG 1189
Cdd:TIGR01967 520 RPMEKQQAADQAHARFKDPRSDFLSRVNLWRHIEEQRQAlsaNQFRNA---CRKQYLNYLRVREWQDIYRQLTQVVKELG 596
|
650 660
....*....|....*....|....*....
gi 564335293 1190 fssstsWEGKKGPQALSFQDIALLKAVLA 1218
Cdd:TIGR01967 597 ------LKLNEEPADYDAIHKALLSGLLS 619
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
554-1190 |
2.73e-91 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 323.16 E-value: 2.73e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 554 RRLQSTPKyqrlLKERQQLPVFKHRASIVETLKRHRVVVVAGETGSGKSTQVPHFLLEdlllndCG-ARKCNIVCTQPRR 632
Cdd:PRK11131 59 LREAARPE----ITYPENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLE------LGrGVKGLIGHTQPRR 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 633 ISAVSLATRVCEELGCEGGpggrnSLCGYQIRMESRASESTRLLYCTTGVLLRKLQEDGLLADVSHVIVDEVHERSVQSD 712
Cdd:PRK11131 129 LAARTVANRIAEELETELG-----GCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNID 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 713 FLLVILKEILQKRSDLHLILMSATVDSDKFSTYFTHCPILRISGRSYPVEVFHlEDIVEEtgfilEKDSEYCQkfLEeee 792
Cdd:PRK11131 204 FILGYLKELLPRRPDLKVIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRY-RPIVEE-----ADDTERDQ--LQ--- 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 793 eitinvtskagGIkkyqecipvqsgaspelspfyqkyssrtqyavlymnphkinLDLILELlvyLDKSPqfrnieGAVLI 872
Cdd:PRK11131 273 -----------AI-----------------------------------------FDAVDEL---GREGP------GDILI 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 873 FLPGLAHIQQLYDLLSNDRRFYSEryqLIALHSVLSTQDQAAAFMlpPPGVRKIVLATNIAETGITIPDVVFVIDTGRTK 952
Cdd:PRK11131 292 FMSGEREIRDTADALNKLNLRHTE---ILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTAR 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 953 ENKYHESSQMSSLVETFVSKASALQRQGRAGRVRDGFCFRLYTRERFEGFLEYSVPEILRVPLEELCLHIMKCDLGSPED 1032
Cdd:PRK11131 367 ISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAA 446
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 1033 FlsKALDPPQPQVISNAMNLLRKIGACEPSEP----KLTPLGQHLAALPVNVKIGKMLIFGAIFGCLEPVATLAAVMTEK 1108
Cdd:PRK11131 447 F--PFVEAPDKRNIQDGVRLLEELGAITTDEQasayKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQ 524
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 1109 SPFITPIGRKDEADLAKSSLAVADSDHLTIYNAYlGWKKAQQE----GGFRSEisyCQRNFLNRTSLLTLEDVKQELMKL 1184
Cdd:PRK11131 525 DPRERPMDKQQASDEKHRRFADKESDFLAFVNLW-NYLQEQQKalssNQFRRL---CRTDYLNYLRVREWQDIYTQLRQV 600
|
....*.
gi 564335293 1185 VRAAGF 1190
Cdd:PRK11131 601 VKELGI 606
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
588-754 |
2.91e-86 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 277.03 E-value: 2.91e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 588 HRVVVVAGETGSGKSTQVPHFLLEDLLlndCGARKCNIVCTQPRRISAVSLATRVCEELGCEGGpggrnSLCGYQIRMES 667
Cdd:cd17917 1 NQVVVIVGETGSGKTTQVPQFLLEDGL---AKGGKGRIVCTQPRRIAAISVAERVAEERGEKLG-----EEVGYQIRFES 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 668 RASESTRLLYCTTGVLLRKLQEDGLLADVSHVIVDEVHERSVQSDFLLVILKEILQKRSDLHLILMSATVDSDKFSTYFT 747
Cdd:cd17917 73 KTSSKTRIKFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFG 152
|
....*..
gi 564335293 748 HCPILRI 754
Cdd:cd17917 153 GAPVIHI 159
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
571-1110 |
2.78e-68 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 247.14 E-value: 2.78e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 571 QLPVFKHRASIVETLKRHRVVVVAGETGSGKSTQVPhflLEDLLLNDCGARkcnIVCTQPRRISAVSLATRVCEELGCEg 650
Cdd:PRK11664 3 SLPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLP---LQLLQHGGINGK---IIMLEPRRLAARNVAQRLAEQLGEK- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 651 gPGGRnslCGYQIRMESRASESTRLLYCTTGVLLRKLQEDGLLADVSHVIVDEVHERSVQSDFLLVILKEILQK-RSDLH 729
Cdd:PRK11664 76 -PGET---VGYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVQQGlRDDLK 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 730 LILMSATVDSDKFSTYFTHCPILRISGRSYPVEvfhlediveetgfilekdseycqkfleeeeeitinvtskaggiKKYQ 809
Cdd:PRK11664 152 LLIMSATLDNDRLQQLLPDAPVIVSEGRSFPVE-------------------------------------------RRYQ 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 810 eciPVQSgaspelspfYQKYSSRTQYAvlymnphkinldlILELLvyldkspqfRNIEGAVLIFLPGLAHIQQLYDLLSN 889
Cdd:PRK11664 189 ---PLPA---------HQRFDEAVARA-------------TAELL---------RQESGSLLLFLPGVGEIQRVQEQLAS 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 890 DrrfYSERYQLIALHSVLSTQDQAAAFMLPPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQMSSLVETF 969
Cdd:PRK11664 235 R---VASDVLLCPLYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLVTQR 311
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 970 VSKASALQRQGRAGRVRDGFCFRLYTRERFEGFLEYSVPEILRVPLEELCLHIMKCDLGSPEDFlsKALDPPQPQVISNA 1049
Cdd:PRK11664 312 ISQASMTQRAGRAGRLEPGICLHLYSKEQAERAAAQSEPEILHSDLSGLLLELLQWGCHDPAQL--SWLDQPPAAALAAA 389
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564335293 1050 MNLLRKIGACEpSEPKLTPLGQHLAALPVNVKIGKMLIFGAIFG-CLEPVATLAAVMTEKSP 1110
Cdd:PRK11664 390 KRLLQQLGALD-GQGRLTARGRKMAALGNDPRLAAMLVAAKEDDeAALATAAKLAAILEEPP 450
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
572-754 |
3.77e-68 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 226.98 E-value: 3.77e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 572 LPVFKHRASIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNDCGARkCNIVCTQPRRISAVSLATRVCEELGcegg 651
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRGRGAR-CNVVITQPRRISAVSVAQRVAHELG---- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 652 PGGRNSLcGYQIRMESRASEST-RLLYCTTGVLLRKLQEDGLLADVSHVIVDEVHERSVQSDFLLVILKEILQKRSDLHL 730
Cdd:cd17976 76 PNLRRNV-GYQVRLESRPPPRGgALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRV 154
|
170 180
....*....|....*....|....
gi 564335293 731 ILMSATVDSDKFSTYFTHCPILRI 754
Cdd:cd17976 155 VLMSATGDNQRLSRYFGGCPVVRV 178
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
520-754 |
1.69e-66 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 224.33 E-value: 1.69e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 520 PEESWENLVS---DEDLSALSLEPTGAEDLEpvRNLFRRLQSTPKYQRLLKERQQLPVFKHRASIVETLKRHRVVVVAGE 596
Cdd:cd17972 6 PQSNWNPWTSsniDEGPLAFATPEQISMDLK--NELMYQREQDHNLQQILQERELLPVKKFREEILEAISNNPVVIIRGA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 597 TGSGKSTQVPHFLLEDLLLNDCGArKCNIVCTQPRRISAVSLATRVCEELGCEGGPGgrnslCGYQIRMES---RASESt 673
Cdd:cd17972 84 TGCGKTTQVPQYILDDFIQNDRAA-ECNIVVTQPRRISAVSVAERVAFERGEEVGKS-----CGYSVRFESvlpRPHAS- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 674 rLLYCTTGVLLRKLqEDGLLAdVSHVIVDEVHERSVQSDFLLVILKEILQKRSDLHLILMSATVDSDKFSTYFTHCPILR 753
Cdd:cd17972 157 -ILFCTVGVLLRKL-EAGIRG-ISHVIVDEIHERDINTDFLLVVLRDVVQAYPDLRVILMSATIDTSMFCEYFFNCPVIE 233
|
.
gi 564335293 754 I 754
Cdd:cd17972 234 V 234
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
572-754 |
1.82e-66 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 222.03 E-value: 1.82e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 572 LPVFKHRASIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNDCGArKCNIVCTQPRRISAVSLATRVCEELGCEGG 651
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDDAIERGKGS-SCRIVCTQPRRISAISVAERVAAERAESCG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 652 PGgrNSLcGYQIRMESR-ASESTRLLYCTTGVLLRKLQEDGLLADVSHVIVDEVHERSVQSDFLLVILKEILQKRSDLHL 730
Cdd:cd17981 80 LG--NST-GYQIRLESRkPRKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKV 156
|
170 180
....*....|....*....|....
gi 564335293 731 ILMSATVDSDKFSTYFTHCPILRI 754
Cdd:cd17981 157 ILMSATLNAEKFSDYFNNCPMIHI 180
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
840-994 |
1.83e-66 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 221.64 E-value: 1.83e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 840 MNPHKINLDLILELLVYLDKSpqfrNIEGAVLIFLPGLAHIQQLYDLL-SNDRRFYSERYQLIALHSVLSTQDQAAAFML 918
Cdd:cd18791 20 EKEDPDYVDAAVRLILQIHRT----EEPGDILVFLPGQEEIERLCELLrEELLSPDLGKLLVLPLHSSLPPEEQQRVFEP 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564335293 919 PPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQMSSLVETFVSKASALQRQGRAGRVRDGFCFRLY 994
Cdd:cd18791 96 PPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRAGRTRPGKCYRLY 171
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
572-754 |
1.75e-64 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 216.25 E-value: 1.75e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 572 LPVFKHRASIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLlNDCGARKCNIVCTQPRRISAVSLATRVCEELGCEGG 651
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSL-QGPPLPVANIICTQPRRISAISVAERVAQERAERVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 652 pggrnSLCGYQIRMESRASESTRLLYCTTGVLLRKLQEDGLLADVSHVIVDEVHERSVQSDFLLVILKEILQKRSDLHLI 731
Cdd:cd17985 80 -----QSVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVI 154
|
170 180
....*....|....*....|...
gi 564335293 732 LMSATVDSDKFSTYFTHCPILRI 754
Cdd:cd17985 155 LMSATLNAELFSDYFNSCPVIHI 177
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
572-754 |
1.66e-57 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 196.20 E-value: 1.66e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 572 LPVFKHRASIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNdcgARKCNIVCTQPRRISAVSLATRVCEELGCEGG 651
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCYAN---GIPCRIFCTQPRRLAAIAVAERVAAERGEKIG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 652 pggrnSLCGYQIRMESRASESTRLLYCTTGVLLRKLQE-DGLLADVSHVIVDEVHERSVQSDFLLVILKEILQKRSDLHL 730
Cdd:cd17987 78 -----QTVGYQIRLESRVSPKTLLTFCTNGVLLRTLMAgDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKL 152
|
170 180
....*....|....*....|....
gi 564335293 731 ILMSATVDSDKFSTYFTHCPILRI 754
Cdd:cd17987 153 ILSSAALDVNLFIRYFGSCPVIYI 176
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
560-754 |
9.69e-57 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 194.56 E-value: 9.69e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 560 PKYQRLLKERQQLPVFKHRASIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNDcgaRKCNIVCTQPRRISAVSLA 639
Cdd:cd17973 1 QRYFEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPHQ---PKKLVACTQPRRVAAMSVA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 640 TRVCEELGCEGGpggrnSLCGYQIRMESRASESTRLLYCTTGVLLRKLQEDGLLADVSHVIVDEVHERSVQSDFLLVILK 719
Cdd:cd17973 78 QRVAEEMDVKLG-----EEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLK 152
|
170 180 190
....*....|....*....|....*....|....*
gi 564335293 720 EILQKRSDLHLILMSATVDSDKFSTYFTHCPILRI 754
Cdd:cd17973 153 EVVRRRPDLKLIVMSATLDAGKFQKYFDNAPLLKV 187
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
572-754 |
4.52e-55 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 189.19 E-value: 4.52e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 572 LPVFKHRASIVETLKRHRVVVVAGETGSGKSTQVPHFLLEdlllndcgARKCNIVCTQPRRISAVSLATRVCEELGCEGG 651
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLA--------AGFRHIACTQPRRIACISLAKRVAFESLNQYG 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 652 pggrnSLCGYQIRMESRASESTRLLYCTTGVLLRKLQEDGLLADVSHVIVDEVHERSVQSDFLLVILKEILQKRSDLHLI 731
Cdd:cd17979 73 -----SKVAYQIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLI 147
|
170 180
....*....|....*....|...
gi 564335293 732 LMSATVDSDKFSTYFTHCPILRI 754
Cdd:cd17979 148 LMSATINIELFSGYFEGAPVVQV 170
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
572-754 |
2.21e-54 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 187.56 E-value: 2.21e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 572 LPVFKHRASIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLlndcgARKCNIVCTQPRRISAVSLATRVCEELGCEGG 651
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGF-----ARGGMIGITQPRRVAAVSVAKRVAEEMGVELG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 652 pggrnSLCGYQIRMESRASESTRLLYCTTGVLLRKLQEDGLLADVSHVIVDEVHERSVQSDFLLVILKEILQKR-----S 726
Cdd:cd17978 76 -----QLVGYSVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRkeqklS 150
|
170 180
....*....|....*....|....*...
gi 564335293 727 DLHLILMSATVDSDKFSTYFTHCPILRI 754
Cdd:cd17978 151 PLKVIIMSATLDADLFSEYFNGAPVLYI 178
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
572-747 |
1.19e-51 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 179.62 E-value: 1.19e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 572 LPVFKHRASIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNdcgARKCNIVCTQPRRISAVSLATRVCEELGCEgg 651
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYYKR---GKYCNIVVTQPRRIAAISIARRVSQEREWT-- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 652 pggRNSLCGYQIRMESRASESTRLLYCTTGVLLRKLQEDGLLADVSHVIVDEVHERSVQSDFLLVILKEILQKRSD-LHL 730
Cdd:cd17988 76 ---LGSLVGYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSRhVKI 152
|
170
....*....|....*..
gi 564335293 731 ILMSATVDSDKFSTYFT 747
Cdd:cd17988 153 ILMSATISCKEFADYFT 169
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
572-754 |
2.87e-50 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 175.34 E-value: 2.87e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 572 LPVFKHRASIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDlllndcGARKCNIV-CTQPRRISAVSLATRVCEELGCEG 650
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHED------GYTDYGMIgCTQPRRVAAMSVAKRVSEEMGVEL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 651 GpggrnSLCGYQIRMESRASESTRLLYCTTGVLLRKLQEDGLLADVSHVIVDEVHERSVQSDFLLVILKEILQKRSDLHL 730
Cdd:cd17983 75 G-----EEVGYAIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKL 149
|
170 180
....*....|....*....|....
gi 564335293 731 ILMSATVDSDKFSTYFTHCPILRI 754
Cdd:cd17983 150 IVTSATMDADKFADFFGNVPIFTI 173
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
568-754 |
1.18e-49 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 173.82 E-value: 1.18e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 568 ERQQLPVFKHRASIVETLKRHRVVVVAGETGSGKSTQVPHFLLEdlllndCG-ARKCNIVCTQPRRISAVSLATRVCEEL 646
Cdd:cd17971 2 QRESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAE------AGyTSRGKIGCTQPRRVAAMSVAKRVAEEF 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 647 GCEGGpggrnSLCGYQIRMESRASESTRLLYCTTGVLLRKLQEDGLLADVSHVIVDEVHERSVQSDFLLVILKEILQKRS 726
Cdd:cd17971 76 GCCLG-----QEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRP 150
|
170 180
....*....|....*....|....*...
gi 564335293 727 DLHLILMSATVDSDKFSTYFTHCPILRI 754
Cdd:cd17971 151 DLKLIVTSATLDAVKFSQYFYEAPIFTI 178
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
572-746 |
3.16e-49 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 173.04 E-value: 3.16e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 572 LPVFKHRASIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNdcGARKcnIVCTQPRRISAVSLATRVCEELGCEGG 651
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAGWTA--GGRV--VGCTQPRRVAAVTVAGRVAEEMGAVLG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 652 pggrnSLCGYQIRMESRASE-STRLLYCTTGVLLRKLQEDGLLADVSHVIVDEVHERSVQSDFLLVILKEILQKRSDLHL 730
Cdd:cd17980 77 -----HEVGYCIRFDDCTDPqATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRL 151
|
170
....*....|....*.
gi 564335293 731 ILMSATVDSDKFSTYF 746
Cdd:cd17980 152 IVASATLDAEKFRDFF 167
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
572-754 |
6.32e-49 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 171.53 E-value: 6.32e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 572 LPVFKHRASIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNDCGarkcNIVCTQPRRISAVSLATRVCEELGCEGG 651
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYTKGGG----KIGCTQPRRVAAMSVAARVAEEMGVKLG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 652 pggrnSLCGYQIRMESRASESTRLLYCTTGVLLRKLQEDGLLADVSHVIVDEVHERSVQSDFLLVILKEILQKRSDLHLI 731
Cdd:cd17974 77 -----NEVGYSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLL 151
|
170 180
....*....|....*....|...
gi 564335293 732 LMSATVDSDKFSTYFTHCPILRI 754
Cdd:cd17974 152 ISSATMDAEKFSAFFDDAPIFRI 174
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
572-743 |
4.46e-47 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 167.15 E-value: 4.46e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 572 LPVFKHRASIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNDCGARKCNIVCTQPRRISAVSLATRVCEELGCEGG 651
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSPESDNPGMIGITQPRRVAAVSMAKRVAEELNVFGK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 652 PggrnslCGYQIRMESRASESTRLLYCTTGVLLRKLQEDGLLADVSHVIVDEVHERSVQSDFLLVILKEILQKRSDLH-- 729
Cdd:cd17982 81 E------VSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKLYlq 154
|
170 180
....*....|....*....|..
gi 564335293 730 --------LILMSATVDSDKFS 743
Cdd:cd17982 155 dqtvkplkLVIMSATLRVEDFT 176
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
572-754 |
6.64e-47 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 165.71 E-value: 6.64e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 572 LPVFKHRASIVETLKRHRVVVVAGETGSGKSTQVPHFLLEdLLLNDCGArkcnIVCTQPRRISAVSLATRVCEELGCEGG 651
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLE-LGRGIRGL----IGHTQPRRLAARSVAERIAEELKTELG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 652 pggrnSLCGYQIRMESRASESTRLLYCTTGVLLRKLQEDGLLADVSHVIVDEVHERSVQSDFLLVILKEILQKRSDLHLI 731
Cdd:cd17989 76 -----GAVGYKVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVI 150
|
170 180
....*....|....*....|...
gi 564335293 732 LMSATVDSDKFSTYFTHCPILRI 754
Cdd:cd17989 151 ITSATIDAERFSRHFNNAPIIEV 173
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
572-754 |
6.74e-42 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 151.55 E-value: 6.74e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 572 LPVFKHRASIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLlndcgARKCNIVCTQPRRISAVSLATRVCEELGCEGG 651
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGF-----SQHGMIGVTQPRRVAAISVAQRVAEEMKCTLG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 652 pggrnSLCGYQIRMESRASESTRLLYCTTGVLLRKLQEDGLLADVSHVIVDEVHERSVQSDFLLVILKEILQKRS----- 726
Cdd:cd17984 76 -----SKVGYQVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFQEKSpnrke 150
|
170 180
....*....|....*....|....*...
gi 564335293 727 DLHLILMSATVDSDKFSTYFTHCPILRI 754
Cdd:cd17984 151 HLKVVVMSATLELAKLSAFFGNCPVFDI 178
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
572-753 |
1.93e-41 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 150.17 E-value: 1.93e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 572 LPVFKHRASIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNdcgARKcnIVCTQPRRISAVSLATRVCEELGCEGG 651
Cdd:cd17990 1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWIA---GGK--IIVLEPRRVAARAAARRLATLLGEAPG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 652 pggrnSLCGYQIRMESRASESTRLLYCTTGVLLRKLQEDGLLADVSHVIVDEVHERSVQSDFLLVILKEILQ-KRSDLHL 730
Cdd:cd17990 76 -----ETVGYRVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQlLRDDLRL 150
|
170 180
....*....|....*....|...
gi 564335293 731 ILMSATVDSDKFSTYFTHCPILR 753
Cdd:cd17990 151 LAMSATLDGDGLAALLPEAPVVE 173
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
572-754 |
1.64e-30 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 119.16 E-value: 1.64e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 572 LPVFKHRASIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNDcgARKCNIVCTQPRRISAVSLATRVCEELGCEGG 651
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEYCLSAH--YQHGVVVCTQVHKQTAVWLALRVADEMDVNIG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 652 pggrnSLCGYQIRMESRASESTRLLYCTTGVLLRKLQEDGLLADVSHVIVDEVHERSVQSDFLLVILKEILQKRSDLHLI 731
Cdd:cd17977 79 -----HEVGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKLV 153
|
170 180
....*....|....*....|...
gi 564335293 732 LMSATVDSDKFSTYFTHCPILRI 754
Cdd:cd17977 154 IITCPHLSSKLLSYYGNVPLIEV 176
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
578-764 |
1.71e-24 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 102.57 E-value: 1.71e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 578 RASIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNDcgarKCNIVCTQPRRisavSLATRVCEELGCEGGPGGRNS 657
Cdd:smart00487 14 KEAIEALLSGLRDVILAAPTGSGKTLAALLPALEALKRGK----GGRVLVLVPTR----ELAEQWAEELKKLGPSLGLKV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 658 LC---GYQIRMESR--ASESTRLLYCTTGVLLRKLQEDGL-LADVSHVIVDEVHERSVQsDFLLVILKEILQKRSDLHLI 731
Cdd:smart00487 86 VGlygGDSKREQLRklESGKTDILVTTPGRLLDLLENDKLsLSNVDLVILDEAHRLLDG-GFGDQLEKLLKLLPKNVQLL 164
|
170 180 190
....*....|....*....|....*....|....*..
gi 564335293 732 LMSAT--VDSDKFSTYFTHCP--ILRISGRSYPVEVF 764
Cdd:smart00487 165 LLSATppEEIENLLELFLNDPvfIDVGFTPLEPIEQF 201
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
572-754 |
6.07e-24 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 100.36 E-value: 6.07e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 572 LPVFKHRASIVETLKRHR-VVVVAGETGSGKSTQVPHFLLEDLLLNdcGARKCNIVCTQPRRISAVSLATRVCEE----L 646
Cdd:cd17986 1 LPIWAAKFTFLEQLESPSgIVLVSGEPGSGKSTQVPQWCAEFALSR--GFQKGQVTVTQPHPLAARSLALRVADEmdlnL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 647 GCEggpggrnslCGYQIRMESRASESTRLLYCTTGVLLRKLQEDGLLADVSHVIVDEVHERSVQSDFLLVILKEILQKRS 726
Cdd:cd17986 79 GHE---------VGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRP 149
|
170 180
....*....|....*....|....*...
gi 564335293 727 DLHLILMSATVDSDKFSTYFTHCPILRI 754
Cdd:cd17986 150 ELRVVVVTSPALEPKLRAFWGNPPVVHV 177
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
1049-1138 |
4.53e-21 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 89.22 E-value: 4.53e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 1049 AMNLLRKIGACEPSEpKLTPLGQHLAALPVNVKIGKMLIFGAIFGCLEPVATLAAVMTEKSPFITPIG------------ 1116
Cdd:pfam04408 1 ALELLYYLGALDEDG-ELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFldprsaakaarr 79
|
90 100
....*....|....*....|....*
gi 564335293 1117 ---RKDEADLAKSSLAVADSDHLTI 1138
Cdd:pfam04408 80 rrrAADEKARAKFARLDLEGDHLTL 104
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
1056-1137 |
1.10e-20 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 87.32 E-value: 1.10e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 1056 IGACEPSEpKLTPLGQHLAALPVNVKIGKMLIFGAIFGCLEPVATLAAVMTEKSPFitPIGRKDEADLAKSSLAVADSDH 1135
Cdd:smart00847 2 LGALDDDG-RLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR--PKEKREDADAARRRFADPESDH 78
|
..
gi 564335293 1136 LT 1137
Cdd:smart00847 79 LT 80
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
1213-1299 |
2.41e-15 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 72.29 E-value: 2.41e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 1213 LKAVLAAGLYDSVGKIMCTKSVDVTEKLacmvetaQGKAQVHPSSVNRDLQT--YGWLLYQEKVRYARVYLRETTLITPF 1290
Cdd:pfam07717 1 LRAALAAGLYPNVARRDPKGKGYTTLSD-------NQRVFIHPSSVLFNEKTfpPEWVVYQELVETTKVYIRTVTAISPE 73
|
....*....
gi 564335293 1291 PVLLFGGDI 1299
Cdd:pfam07717 74 WLLLFAPHI 82
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
591-736 |
3.62e-14 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 70.90 E-value: 3.62e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 591 VVVAGETGSGKSTQVPHFLLEDLLlndcgARKCNIVCTQPRRISAVSLAtrvcEELGCEGGPGGRNSLCGYQIRMESRAS 670
Cdd:cd00046 4 VLITAPTGSGKTLAALLAALLLLL-----KKGKKVLVLVPTKALALQTA----ERLRELFGPGIRVAVLVGGSSAEEREK 74
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564335293 671 ESTR---LLYCTTGVLLRKLQEDGLL--ADVSHVIVDEVHERSVQSDFLLVI-LKEILQKRSDLHLILMSAT 736
Cdd:cd00046 75 NKLGdadIIIATPDMLLNLLLREDRLflKDLKLIIVDEAHALLIDSRGALILdLAVRKAGLKNAQVILLSAT 146
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
579-740 |
3.06e-13 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 68.81 E-value: 3.06e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 579 ASIVETLKRHRVVVVAGETGSGKST--QVPhfLLEDLLLNDCGARkcnIVCTQPRRisavSLAT---RVCEELGCEGGPG 653
Cdd:pfam00270 5 AEAIPAILEGRDVLVQAPTGSGKTLafLLP--ALEALDKLDNGPQ---ALVLAPTR----ELAEqiyEELKKLGKGLGLK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 654 GRNSLCGYQIRMESRASESTRLLYCTTGVLLRKLQEDGLLADVSHVIVDEVHeRSVQSDFlLVILKEIL-QKRSDLHLIL 732
Cdd:pfam00270 76 VASLLGGDSRKEQLEKLKGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAH-RLLDMGF-GPDLEEILrRLPKKRQILL 153
|
....*...
gi 564335293 733 MSATVDSD 740
Cdd:pfam00270 154 LSATLPRN 161
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
881-984 |
9.85e-13 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 64.93 E-value: 9.85e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 881 QQLYDLLSNdrrfysERYQLIALHSVLSTQDQAAAFMLPPPGVRKIVLATNIAETGITIPDVVFVIDTGrtkenkyhess 960
Cdd:smart00490 1 EELAELLKE------LGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYD----------- 63
|
90 100
....*....|....*....|....
gi 564335293 961 qmsslveTFVSKASALQRQGRAGR 984
Cdd:smart00490 64 -------LPWSPASYIQRIGRAGR 80
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
581-995 |
7.27e-10 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 63.46 E-value: 7.27e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 581 IVETLKRHRVVVVAGETGSGKSTQVPHFLL---------EDLLLNDCGARKCNIVCTQPRrISAVSLATRV-CEELGCEG 650
Cdd:PHA02653 172 IFEAWISRKPVVLTGGTGVGKTSQVPKLLLwfnylfggfDNLDKIDPNFIERPIVLSLPR-VALVRLHSITlLKSLGFDE 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 651 GPGGRNSLcGYQIRMESRASESTR---LLYCTTGVLLRKLQedgllaDVSHVIVDEVHERSVQSDFLLVIL-KEILQKRS 726
Cdd:PHA02653 251 IDGSPISL-KYGSIPDELINTNPKpygLVFSTHKLTLNKLF------DYGTVIIDEVHEHDQIGDIIIAVArKHIDKIRS 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 727 dlhLILMSATV--DSDKFSTYFTHCPILRISGRS-YPV-EVFhlediVEETGFILEKdseycQKFLEEEEEitiNVTSka 802
Cdd:PHA02653 324 ---LFLMTATLedDRDRIKEFFPNPAFVHIPGGTlFPIsEVY-----VKNKYNPKNK-----RAYIEEEKK---NIVT-- 385
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 803 gGIKKYQeciPVQsGASPELspFYQKYSSRTQYAVlYMNPHKINLDlilellvyldkspqFRNIEGAVliflPGLAHIqq 882
Cdd:PHA02653 386 -ALKKYT---PPK-GSSGIV--FVASVSQCEEYKK-YLEKRLPIYD--------------FYIIHGKV----PNIDEI-- 437
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 883 LYDLLSNDRrfyseryqlIAlhsvlstqdqaaafmlpppgvrkIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQM 962
Cdd:PHA02653 438 LEKVYSSKN---------PS-----------------------IIISTPYLESSVTIRNATHVYDTGRVYVPEPFGGKEM 485
|
410 420 430
....*....|....*....|....*....|...
gi 564335293 963 sslvetFVSKASALQRQGRAGRVRDGFCFRLYT 995
Cdd:PHA02653 486 ------FISKSMRTQRKGRVGRVSPGTYVYFYD 512
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
864-985 |
1.19e-09 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 56.84 E-value: 1.19e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 864 RNIEGAVLIFLPGLAHIQqlYDLLSNdrrfySERYQLIALHSVLSTQDQAAAFMLPPPGVRKIVLATNIAETGITIPDVV 943
Cdd:pfam00271 12 KERGGKVLIFSQTKKTLE--AELLLE-----KEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPDVD 84
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 564335293 944 FVIDTGRTKenkyhessqmsslvetfvSKASALQRQGRAGRV 985
Cdd:pfam00271 85 LVINYDLPW------------------NPASYIQRIGRAGRA 108
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
512-942 |
2.94e-06 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 51.56 E-value: 2.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 512 NKTETAEDPEESWENLVSDEDLSALSLEPTGAEDLEPVRNLFRRLQSTPKYQRLLKERQQLPVFK-----HRASIVETLK 586
Cdd:COG1061 14 LRSSLLLLDLERLELSLLRNLVEARRLAIKEGTREDGRRLPEEDTERELAEAEALEAGDEASGTSfelrpYQQEALEALL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 587 RH------RVVVVAGeTGSGKSTqvphFLLEDLLLNDCGARKCnIVCtqPRRISAVSLATRVCEELGCEGGPGGRNSlcg 660
Cdd:COG1061 94 AAlergggRGLVVAP-TGTGKTV----LALALAAELLRGKRVL-VLV--PRRELLEQWAEELRRFLGDPLAGGGKKD--- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 661 yqirmesrasESTRLLYCTTGVLLRKLQEDGLLADVSHVIVDEVHERSVQSdfllviLKEILQKRSDLHLILMSATvdsd 740
Cdd:COG1061 163 ----------SDAPITVATYQSLARRAHLDELGDRFGLVIIDEAHHAGAPS------YRRILEAFPAAYRLGLTAT---- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 741 kfstyfthcPIlRISGRsyPVEVFHLEDIVEETGfilekdseycqkfLEEEEEitinvtskAGGIKKYqECIPVQSGASP 820
Cdd:COG1061 223 ---------PF-RSDGR--EILLFLFDGIVYEYS-------------LKEAIE--------DGYLAPP-EYYGIRVDLTD 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 821 ELSPfYQKYSSRTQYAVLYMNPHKinlDLILEllVYLDKSPQFRniegAVLIFLPGLAHIQQLYDLLSndrrfySERYQL 900
Cdd:COG1061 269 ERAE-YDALSERLREALAADAERK---DKILR--ELLREHPDDR----KTLVFCSSVDHAEALAELLN------EAGIRA 332
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 564335293 901 IALHSVLSTQDQAAAFMLPPPGVRKIVLATNIAETGITIPDV 942
Cdd:COG1061 333 AVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRL 374
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
925-984 |
1.42e-04 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 41.54 E-value: 1.42e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 925 KIVLATNIAETGITIPDVVFVIDTGRTKenkyhessqmsslvetfvSKASALQRQGRAGR 984
Cdd:cd18785 24 EILVATNVLGEGIDVPSLDTVIFFDPPS------------------SAASYIQRVGRAGR 65
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
585-754 |
3.08e-04 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 43.02 E-value: 3.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 585 LKRHRVVVVAGeTGSGKStqvphFLLEDLLLNDCGARKCNIVCTQPRRisavSLATRVCEELGCEGGPGGRN-SLCGYQI 663
Cdd:cd17921 15 LSGDSVLVSAP-TSSGKT-----LIAELAILRALATSGGKAVYIAPTR----ALVNQKEADLRERFGPLGKNvGLLTGDP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 664 RMESRASESTRLLYCTT---GVLLRKLQEDGLLaDVSHVIVDEVH--ERSVQSDFLLVILKEILQKRSDLHLILMSATVD 738
Cdd:cd17921 85 SVNKLLLAEADILVATPeklDLLLRNGGERLIQ-DVRLVVVDEAHliGDGERGVVLELLLSRLLRINKNARFVGLSATLP 163
|
170
....*....|....*..
gi 564335293 739 S-DKFSTYFTHCPILRI 754
Cdd:cd17921 164 NaEDLAEWLGVEDLIRF 180
|
|
| AAA_22 |
pfam13401 |
AAA domain; |
589-733 |
2.59e-03 |
|
AAA domain;
Pssm-ID: 379165 [Multi-domain] Cd Length: 129 Bit Score: 39.25 E-value: 2.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335293 589 RVVVVAGETGSGKSTqvphfLLEDLLLNDCGARKCNIVCTQPRRISAVSLATRVCEELGCEGGPGGRNSLCGYQIRMESR 668
Cdd:pfam13401 6 GILVLTGESGTGKTT-----LLRRLLEQLPEVRDSVVFVDLPSGTSPKDLLRALLRALGLPLSGRLSKEELLAALQQLLL 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564335293 669 ASESTRLLycttgvllrklqedglladvshvIVDEVHERSVQSDFLLVILKEIlqKRSDLHLILM 733
Cdd:pfam13401 81 ALAVAVVL-----------------------IIDEAQHLSLEALEELRDLLNL--SSKLLQLILV 120
|
|
| |
