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Conserved domains on  [gi|1958752768|ref|XP_006233239|]
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proline/serine-rich coiled-coil protein 1 isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GTSE1_N super family cl21116
G-2 and S-phase expressed 1; This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S ...
 61-175 3.98e-12

G-2 and S-phase expressed 1; This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S phase-expressed-1) protein is specifically expressed during S and G2 phases of the cell cycle. It is mainly localized to the microtubules and when overexpressed delays the G2 to M transition. the full protein negatively regulates p53 transactivation function, protein levels, and p53-dependent apoptosis. This domain family is found in eukaryotes, and is approximately 140 amino acids in length. There is a conserved FDFD sequence motif.


The actual alignment was detected with superfamily member pfam15259:

Pssm-ID: 464599 [Multi-domain]  Cd Length: 144  Bit Score: 63.49  E-value: 3.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752768  61 FIVDETLDFGgLSPSDSHEEEDITVLVSPEKPLRRGLS-----HRSNPNAVAPALQGVRFSLGPLSPEKLEEILDEANRL 135
Cdd:pfam15259   3 LLADEKFDFD-LSLSPSSANEDDEVFVGPVGHKERCVAasvelNSQIPKQPLLPGSESPTSWSPLTGEKFVEVYKEAHLL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958752768 136 AAQLeECALKDSENAAAGPGRP---------------------------SPRgkpSPRRETFVLKDS 175
Cdd:pfam15259  82 ALQL-ESSSKNEAAKAAQPEDPssqgvekfvqdsklklnlfekekemekSPR---SIKRETYCVQDS 144
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 182-348 3.14e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.98  E-value: 3.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752768 182 PTVSSWSAPPPSNLTGLRSSDKKGSARAGRVTAGKKPSSIKKESPTcnlfSASKNPGRSPLAQPTLPPRRKTGSGARTVA 261
Cdd:pfam05109 432 PTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPT----PAGTTSGASPVTPSPSPRDNGTESKAPDMT 507

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752768 262 SP--------PIPVRPAPQSSASNSQCSSWLQGAAAKSSS-RLPFPSAI-PKPAIRMPLTGRSIPAgKGALAPDP---LP 328
Cdd:pfam05109 508 SPtsavttptPNATSPTPAVTTPTPNATSPTLGKTSPTSAvTTPTPNATsPTPAVTTPTPNATIPT-LGKTSPTSavtTP 586

                         170       180
                  ....*....|....*....|
gi 1958752768 329 TQKGHPSTVGHRAPVSQRTN 348
Cdd:pfam05109 587 TPNATSPTVGETSPQANTTN 606
 
Name Accession Description Interval E-value
GTSE1_N pfam15259
G-2 and S-phase expressed 1; This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S ...
 61-175 3.98e-12

G-2 and S-phase expressed 1; This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S phase-expressed-1) protein is specifically expressed during S and G2 phases of the cell cycle. It is mainly localized to the microtubules and when overexpressed delays the G2 to M transition. the full protein negatively regulates p53 transactivation function, protein levels, and p53-dependent apoptosis. This domain family is found in eukaryotes, and is approximately 140 amino acids in length. There is a conserved FDFD sequence motif.


Pssm-ID: 464599 [Multi-domain]  Cd Length: 144  Bit Score: 63.49  E-value: 3.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752768  61 FIVDETLDFGgLSPSDSHEEEDITVLVSPEKPLRRGLS-----HRSNPNAVAPALQGVRFSLGPLSPEKLEEILDEANRL 135
Cdd:pfam15259   3 LLADEKFDFD-LSLSPSSANEDDEVFVGPVGHKERCVAasvelNSQIPKQPLLPGSESPTSWSPLTGEKFVEVYKEAHLL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958752768 136 AAQLeECALKDSENAAAGPGRP---------------------------SPRgkpSPRRETFVLKDS 175
Cdd:pfam15259  82 ALQL-ESSSKNEAAKAAQPEDPssqgvekfvqdsklklnlfekekemekSPR---SIKRETYCVQDS 144
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 182-348 3.14e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.98  E-value: 3.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752768 182 PTVSSWSAPPPSNLTGLRSSDKKGSARAGRVTAGKKPSSIKKESPTcnlfSASKNPGRSPLAQPTLPPRRKTGSGARTVA 261
Cdd:pfam05109 432 PTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPT----PAGTTSGASPVTPSPSPRDNGTESKAPDMT 507

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752768 262 SP--------PIPVRPAPQSSASNSQCSSWLQGAAAKSSS-RLPFPSAI-PKPAIRMPLTGRSIPAgKGALAPDP---LP 328
Cdd:pfam05109 508 SPtsavttptPNATSPTPAVTTPTPNATSPTLGKTSPTSAvTTPTPNATsPTPAVTTPTPNATIPT-LGKTSPTSavtTP 586

                         170       180
                  ....*....|....*....|
gi 1958752768 329 TQKGHPSTVGHRAPVSQRTN 348
Cdd:pfam05109 587 TPNATSPTVGETSPQANTTN 606
 
Name Accession Description Interval E-value
GTSE1_N pfam15259
G-2 and S-phase expressed 1; This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S ...
 61-175 3.98e-12

G-2 and S-phase expressed 1; This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S phase-expressed-1) protein is specifically expressed during S and G2 phases of the cell cycle. It is mainly localized to the microtubules and when overexpressed delays the G2 to M transition. the full protein negatively regulates p53 transactivation function, protein levels, and p53-dependent apoptosis. This domain family is found in eukaryotes, and is approximately 140 amino acids in length. There is a conserved FDFD sequence motif.


Pssm-ID: 464599 [Multi-domain]  Cd Length: 144  Bit Score: 63.49  E-value: 3.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752768  61 FIVDETLDFGgLSPSDSHEEEDITVLVSPEKPLRRGLS-----HRSNPNAVAPALQGVRFSLGPLSPEKLEEILDEANRL 135
Cdd:pfam15259   3 LLADEKFDFD-LSLSPSSANEDDEVFVGPVGHKERCVAasvelNSQIPKQPLLPGSESPTSWSPLTGEKFVEVYKEAHLL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958752768 136 AAQLeECALKDSENAAAGPGRP---------------------------SPRgkpSPRRETFVLKDS 175
Cdd:pfam15259  82 ALQL-ESSSKNEAAKAAQPEDPssqgvekfvqdsklklnlfekekemekSPR---SIKRETYCVQDS 144
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 182-348 3.14e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.98  E-value: 3.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752768 182 PTVSSWSAPPPSNLTGLRSSDKKGSARAGRVTAGKKPSSIKKESPTcnlfSASKNPGRSPLAQPTLPPRRKTGSGARTVA 261
Cdd:pfam05109 432 PTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPT----PAGTTSGASPVTPSPSPRDNGTESKAPDMT 507

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752768 262 SP--------PIPVRPAPQSSASNSQCSSWLQGAAAKSSS-RLPFPSAI-PKPAIRMPLTGRSIPAgKGALAPDP---LP 328
Cdd:pfam05109 508 SPtsavttptPNATSPTPAVTTPTPNATSPTLGKTSPTSAvTTPTPNATsPTPAVTTPTPNATIPT-LGKTSPTSavtTP 586

                         170       180
                  ....*....|....*....|
gi 1958752768 329 TQKGHPSTVGHRAPVSQRTN 348
Cdd:pfam05109 587 TPNATSPTVGETSPQANTTN 606
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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