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Conserved domains on  [gi|564368920|ref|XP_006245220|]
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fibronectin isoform X10 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 353-401 5.85e-24

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


:

Pssm-ID: 128373  Cd Length: 49  Bit Score: 96.21  E-value: 5.85e-24
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 564368920    353 GNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 413-461 2.18e-23

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


:

Pssm-ID: 128373  Cd Length: 49  Bit Score: 94.67  E-value: 2.18e-23
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 564368920    413 GNSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
fn3 pfam00041
Fibronectin type III domain;
1448-1529 1.33e-19

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 85.16  E-value: 1.33e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  1448 DVPRDLEVIASTPTSLLISWEPPAVS---VRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRG 1524
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 564368920  1525 DSPAS 1529
Cdd:pfam00041   81 EGPPS 85
fn3 pfam00041
Fibronectin type III domain;
1542-1622 3.69e-19

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 84.00  E-value: 3.69e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  1542 DKPSQMQVTDVQDNSISVRWLPST---SPVTGYRVTTAPKNGLGPTKSQTVSPDQTEMTIEGLQPTVEYVVSVYAQNRNG 1618
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 564368920  1619 ESQP 1622
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
993-1537 1.10e-17

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 89.29  E-value: 1.10e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  993 TTKLDAPTNLQFVNETDRTVLVTWTPPRARIAGYRLTVGLTRGGQPKQYNVGPMASKYPLRNLQPG--SEYTVTLMAVKG 1070
Cdd:COG3401    54 TLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSpaVGTATTATAVAG 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1071 NQQSPKATGVFTTLQPLRSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGgeapreVTSDSGSIVVSGLTPGVEYTY 1150
Cdd:COG3401   134 GAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLT------VTSTTLVDGGGDIEPGTTYYY 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1151 TIQVLRDGQERDAPIVNRVV---TPLSPPTNLHLEANPDTGVlTVSWERSTTPDITGYRITTTPTNGQQGTALEEVvhaD 1227
Cdd:COG3401   208 RVAATDTGGESAPSNEVSVTtptTPPSAPTGLTATADTPGSV-TLSWDPVTESDATGYRVYRSNSGDGPFTKVATV---T 283

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1228 QSSCTFENLNPGLEYNVSVYTVKDDKESAPISDTV-----IPAVPPPTDLRFTNIGPDTMRVTWAPPPSIELTNLLVrYS 1302
Cdd:COG3401   284 TTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVsvttdLTPPAAPSGLTATAVGSSSITLSWTASSDADVTGYNV-YR 362

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1303 PVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVY---------EQHESIPLRGRQKTGLDSPTGFDSSDVTANSF 1373
Cdd:COG3401   363 STSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDaagnesapsEEVSATTASAASGESLTASVDAVPLTDVAGAT 442

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1374 TVHWVAPRAPITGYIIRH-HAEHSAGRPRQDRVppsrNSITLTNLNPGTEYIVTIIAVNGREESPPLIGQQSTVSDVPRD 1452
Cdd:COG3401   443 AAASAASNPGVSAAVLADgGDTGNAVPFTTTSS----TVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAA 518

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1453 LEVIASTPTSLLISWEPPAVSVRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDSPASSKP 1532
Cdd:COG3401   519 AVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSGAGLGSGNLYLITTLGGSLLTTTSTNTNDVAGVHGG 598


                  ....*
gi 564368920 1533 VSINY 1537
Cdd:COG3401   599 TLLVL 603
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1903-1983 1.04e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.15  E-value: 1.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1903 DAPSNLRFLTTTPNSLLVSWQAPR---ARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 1979
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 564368920 1980 KSEP 1983
Cdd:cd00063    82 ESPP 85
fn3 pfam00041
Fibronectin type III domain;
811-882 8.67e-16

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 74.37  E-value: 8.67e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564368920   811 DAPPDPTVDQVDDTSIVVRWSRP---QAPITGYRIVYSPSVEGS-STELNLPETANSVTLSDLQPGVQYNITIYAV 882
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
fn3 pfam00041
Fibronectin type III domain;
1722-1802 1.06e-15

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.99  E-value: 1.06e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  1722 PAPTNLKFTQVSPTTLTAQWTAP---SVKLTGYRVRVTPKEKTGPMKEINLSPDSTSVIVSGLMVATKYEVSVYALKDTL 1798
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 564368920  1799 TSRP 1802
Cdd:pfam00041   81 EGPP 84
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
698-1033 5.71e-15

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 80.82  E-value: 5.71e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  698 TTSASTPVTSNTVTGETAPFSPVVATSESVTEITASSFVVSWVSASDT-VSGFRVEYELSEEGdEPQYLDlPSTATSVNI 776
Cdd:COG3401   212 TDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDG-PFTKVA-TVTTTSYTD 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  777 PDLLPGRKY---IVNVYQISEEGKQSLILS-TSQTTAPDAPPDPTVDQVDDTSIVVRWS-RPQAPITGYRIVYSPSVEGS 851
Cdd:COG3401   290 TGLTNGTTYyyrVTAVDAAGNESAPSNVVSvTTDLTPPAAPSGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGT 369

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  852 STELNLPETANSVTLSDLQPGVQYNITIYAV----EENQESTPVFIQQETTGVPRSDDVPAPKDLQFVEVTDVKVTIMWT 927
Cdd:COG3401   370 YTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdaagNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAAS 449

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  928 PPNSAVTGYRVDVLPVNLPgehgqrlPVNRNTFAEVTGLSPGVTYLFKVFAVHQGRESKPLTAQQTTKLDAPTNLQFVNE 1007
Cdd:COG3401   450 NPGVSAAVLADGGDTGNAV-------PFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGG 522

                         330       340
                  ....*....|....*....|....*.
gi 564368920 1008 TDRTVLVTWTPPRARIAGYRLTVGLT 1033
Cdd:COG3401   523 APDGTPNVTGASPVTVGASTGDVLIT 548
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 187-231 6.29e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 70.46  E-value: 6.29e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 564368920    187 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGNGRITCTSRNR 231
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
232-271 1.42e-14

Fibronectin type I domain;


:

Pssm-ID: 459644  Cd Length: 40  Bit Score: 69.26  E-value: 1.42e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564368920   232 CNDQDTRTSYRIGDTWSKKDNRGNLLQCVCTGNGRGEWKC 271
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2130-2171 1.93e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.30  E-value: 1.93e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 564368920   2130 CHDN--GVNYKIGEKWDRQGENGQRMSCTCLGNGKGEFKCDPHE 2171
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVP 44
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2085-2129 1.99e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.92  E-value: 1.99e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 564368920   2085 CFDPYTVSHYAVGEEWERLSDSGFKLTCQCLGFGSGHFRCDSSKW 2129
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn3 pfam00041
Fibronectin type III domain;
1814-1893 4.27e-14

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.37  E-value: 4.27e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  1814 SPPRRARVTDATETTITISWRTKTE---TITGFQVDAIPANGQTPVQ-RTISPDVRSYTITGLQPGTDYKIHLYTLNDNA 1889
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNeITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 564368920  1890 RSSP 1893
Cdd:pfam00041   81 EGPP 84
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 561-604 4.65e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.15  E-value: 4.65e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 564368920    561 CQDSETRTFYQIGDSWEK-FVHGVRYQCYCYGRGIGEWHCQPLQT 604
Cdd:smart00058    1 CFDEETGTTYRVGDTWERpYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 470-513 5.71e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 67.76  E-value: 5.71e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 564368920    470 CTTNE-GVMYRIGDQWDKQHDLGHMMRCTCVGNGRGEWACIPYSQ 513
Cdd:smart00058    1 CFDEEtGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 518-560 2.86e-13

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 65.84  E-value: 2.86e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 564368920    518 CIVDD--ITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPIDQ 560
Cdd:smart00058    1 CFDEEtgTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 98-141 7.25e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 61.98  E-value: 7.25e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 564368920     98 CFDKYTGNTYKVGDTYERPKDS-MIWDCTCIGAGRGRISCTIANR 141
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGgHVLQCTCLGGGRGEWKCDPVPV 45
fn3 pfam00041
Fibronectin type III domain;
619-688 1.02e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 1.02e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564368920   619 TPSQPNSHPIQWNAPEP--SHITKYILRWRPKTSTGRWKEATIPGHLNSYTIKGLTPGVIYEGQLISIQQYG 688
Cdd:pfam00041    9 TDVTSTSLTVSWTPPPDgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2173-2212 1.08e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


:

Pssm-ID: 238018  Cd Length: 43  Bit Score: 61.19  E-value: 1.08e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 564368920 2173 TCYDD--GKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNC 2212
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDPV 43
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 142-185 2.04e-11

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 60.44  E-value: 2.04e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 564368920    142 CHEG--GQSYKIGDKWRRPHEtGGYMLECLCLGNGKGEWTCKPIAE 185
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYE-GGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 53-90 6.83e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


:

Pssm-ID: 238018  Cd Length: 43  Bit Score: 58.88  E-value: 6.83e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 564368920   53 CFDN--GKHYQINQQWERTYLGNALVCTCYGGSRGFNCES 90
Cdd:cd00061     3 CFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDP 42
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1632-1719 8.42e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.59  E-value: 8.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1632 DRPKGLAFTDVDVDSIKIAWESPQ---GQVSRYRVTYSSPEDGIHELFPAPDGDEDTAELHGLRPGSEYTVSVVALHGGM 1708
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 564368920 1709 ESQPLIGVQST 1719
Cdd:cd00063    82 ESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
1999-2057 6.65e-07

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 6.65e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564368920  1999 TISWT-PFQESSE---YIISCQPVGTDEEPLQFQVPGTSTSATLTGLTRGVTYNIIVEALHNQ 2057
Cdd:pfam00041   17 TVSWTpPPDGNGPitgYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 308-347 1.42e-04

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 41.18  E-value: 1.42e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 564368920    308 CVTD-SGVVYSVGMQWLK-SQGDKQMLCTCLGNG---VSCQETAV 347
Cdd:smart00058    1 CFDEeTGTTYRVGDTWERpYEGGHVLQCTCLGGGrgeWKCDPVPV 45
 
Name Accession Description Interval E-value
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 353-401 5.85e-24

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 96.21  E-value: 5.85e-24
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 564368920    353 GNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 413-461 2.18e-23

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 94.67  E-value: 2.18e-23
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 564368920    413 GNSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 354-401 2.19e-22

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 91.98  E-value: 2.19e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 564368920  354 NSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:cd00062     1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 414-461 2.71e-22

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 91.60  E-value: 2.71e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 564368920  414 NSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:cd00062     1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
fn2 pfam00040
Fibronectin type II domain;
360-401 2.17e-20

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 86.08  E-value: 2.17e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 564368920   360 CVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
fn3 pfam00041
Fibronectin type III domain;
1448-1529 1.33e-19

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 85.16  E-value: 1.33e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  1448 DVPRDLEVIASTPTSLLISWEPPAVS---VRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRG 1524
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 564368920  1525 DSPAS 1529
Cdd:pfam00041   81 EGPPS 85
fn3 pfam00041
Fibronectin type III domain;
1542-1622 3.69e-19

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 84.00  E-value: 3.69e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  1542 DKPSQMQVTDVQDNSISVRWLPST---SPVTGYRVTTAPKNGLGPTKSQTVSPDQTEMTIEGLQPTVEYVVSVYAQNRNG 1618
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 564368920  1619 ESQP 1622
Cdd:pfam00041   81 EGPP 84
fn2 pfam00040
Fibronectin type II domain;
420-461 4.91e-19

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 82.23  E-value: 4.91e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 564368920   420 CHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
993-1537 1.10e-17

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 89.29  E-value: 1.10e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  993 TTKLDAPTNLQFVNETDRTVLVTWTPPRARIAGYRLTVGLTRGGQPKQYNVGPMASKYPLRNLQPG--SEYTVTLMAVKG 1070
Cdd:COG3401    54 TLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSpaVGTATTATAVAG 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1071 NQQSPKATGVFTTLQPLRSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGgeapreVTSDSGSIVVSGLTPGVEYTY 1150
Cdd:COG3401   134 GAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLT------VTSTTLVDGGGDIEPGTTYYY 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1151 TIQVLRDGQERDAPIVNRVV---TPLSPPTNLHLEANPDTGVlTVSWERSTTPDITGYRITTTPTNGQQGTALEEVvhaD 1227
Cdd:COG3401   208 RVAATDTGGESAPSNEVSVTtptTPPSAPTGLTATADTPGSV-TLSWDPVTESDATGYRVYRSNSGDGPFTKVATV---T 283

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1228 QSSCTFENLNPGLEYNVSVYTVKDDKESAPISDTV-----IPAVPPPTDLRFTNIGPDTMRVTWAPPPSIELTNLLVrYS 1302
Cdd:COG3401   284 TTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVsvttdLTPPAAPSGLTATAVGSSSITLSWTASSDADVTGYNV-YR 362

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1303 PVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVY---------EQHESIPLRGRQKTGLDSPTGFDSSDVTANSF 1373
Cdd:COG3401   363 STSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDaagnesapsEEVSATTASAASGESLTASVDAVPLTDVAGAT 442

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1374 TVHWVAPRAPITGYIIRH-HAEHSAGRPRQDRVppsrNSITLTNLNPGTEYIVTIIAVNGREESPPLIGQQSTVSDVPRD 1452
Cdd:COG3401   443 AAASAASNPGVSAAVLADgGDTGNAVPFTTTSS----TVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAA 518

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1453 LEVIASTPTSLLISWEPPAVSVRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDSPASSKP 1532
Cdd:COG3401   519 AVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSGAGLGSGNLYLITTLGGSLLTTTSTNTNDVAGVHGG 598


                  ....*
gi 564368920 1533 VSINY 1537
Cdd:COG3401   599 TLLVL 603
fn3 pfam00041
Fibronectin type III domain;
1358-1438 1.01e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 77.07  E-value: 1.01e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  1358 DSPTGFDSSDVTANSFTVHWVAPR---APITGYIIRHHAEHSAGRPRQDRVPPSRNSITLTNLNPGTEYIVTIIAVNGRE 1434
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 564368920  1435 ESPP 1438
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1903-1983 1.04e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.15  E-value: 1.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1903 DAPSNLRFLTTTPNSLLVSWQAPR---ARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 1979
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 564368920 1980 KSEP 1983
Cdd:cd00063    82 ESPP 85
fn3 pfam00041
Fibronectin type III domain;
811-882 8.67e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 74.37  E-value: 8.67e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564368920   811 DAPPDPTVDQVDDTSIVVRWSRP---QAPITGYRIVYSPSVEGS-STELNLPETANSVTLSDLQPGVQYNITIYAV 882
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
fn3 pfam00041
Fibronectin type III domain;
1722-1802 1.06e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.99  E-value: 1.06e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  1722 PAPTNLKFTQVSPTTLTAQWTAP---SVKLTGYRVRVTPKEKTGPMKEINLSPDSTSVIVSGLMVATKYEVSVYALKDTL 1798
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 564368920  1799 TSRP 1802
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
1903-1983 2.19e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.22  E-value: 2.19e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  1903 DAPSNLRFLTTTPNSLLVSWQAPRAR---ITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 1979
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 564368920  1980 KSEP 1983
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 810-898 2.73e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 73.30  E-value: 2.73e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  810 PDAPPDPTVDQVDDTSIVVRWSRPQ---APITGYRIVYSPSVEGSSTELNLPE-TANSVTLSDLQPGVQYNITIYAVEEN 885
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 564368920  886 QESTPVFIQQETT 898
Cdd:cd00063    81 GESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
698-1033 5.71e-15

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 80.82  E-value: 5.71e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  698 TTSASTPVTSNTVTGETAPFSPVVATSESVTEITASSFVVSWVSASDT-VSGFRVEYELSEEGdEPQYLDlPSTATSVNI 776
Cdd:COG3401   212 TDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDG-PFTKVA-TVTTTSYTD 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  777 PDLLPGRKY---IVNVYQISEEGKQSLILS-TSQTTAPDAPPDPTVDQVDDTSIVVRWS-RPQAPITGYRIVYSPSVEGS 851
Cdd:COG3401   290 TGLTNGTTYyyrVTAVDAAGNESAPSNVVSvTTDLTPPAAPSGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGT 369

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  852 STELNLPETANSVTLSDLQPGVQYNITIYAV----EENQESTPVFIQQETTGVPRSDDVPAPKDLQFVEVTDVKVTIMWT 927
Cdd:COG3401   370 YTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdaagNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAAS 449

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  928 PPNSAVTGYRVDVLPVNLPgehgqrlPVNRNTFAEVTGLSPGVTYLFKVFAVHQGRESKPLTAQQTTKLDAPTNLQFVNE 1007
Cdd:COG3401   450 NPGVSAAVLADGGDTGNAV-------PFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGG 522

                         330       340
                  ....*....|....*....|....*.
gi 564368920 1008 TDRTVLVTWTPPRARIAGYRLTVGLT 1033
Cdd:COG3401   523 APDGTPNVTGASPVTVGASTGDVLIT 548
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 187-231 6.29e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 70.46  E-value: 6.29e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 564368920    187 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGNGRITCTSRNR 231
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
232-271 1.42e-14

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 69.26  E-value: 1.42e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564368920   232 CNDQDTRTSYRIGDTWSKKDNRGNLLQCVCTGNGRGEWKC 271
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1358-1438 1.86e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.99  E-value: 1.86e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1358 DSPTGFDSSDVTANSFTVHWVAPR---APITGYIIRHHAEHSAGRPRQDRVPPSRNSITLTNLNPGTEYIVTIIAVNGRE 1434
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 564368920 1435 ESPP 1438
Cdd:cd00063    82 ESPP 85
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2130-2171 1.93e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.30  E-value: 1.93e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 564368920   2130 CHDN--GVNYKIGEKWDRQGENGQRMSCTCLGNGKGEFKCDPHE 2171
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVP 44
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2085-2129 1.99e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.92  E-value: 1.99e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 564368920   2085 CFDPYTVSHYAVGEEWERLSDSGFKLTCQCLGFGSGHFRCDSSKW 2129
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 232-274 3.21e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.53  E-value: 3.21e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 564368920    232 CNDQDTRTSYRIGDTWSKKDNRGNLLQCVCTGNGRGEWKCERH 274
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPV 43
fn3 pfam00041
Fibronectin type III domain;
1814-1893 4.27e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.37  E-value: 4.27e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  1814 SPPRRARVTDATETTITISWRTKTE---TITGFQVDAIPANGQTPVQ-RTISPDVRSYTITGLQPGTDYKIHLYTLNDNA 1889
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNeITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 564368920  1890 RSSP 1893
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1448-1530 4.51e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.83  E-value: 4.51e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1448 DVPRDLEVIASTPTSLLISWEPPAVS---VRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRG 1524
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....*.
gi 564368920 1525 DSPASS 1530
Cdd:cd00063    82 ESPPSE 87
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 561-604 4.65e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.15  E-value: 4.65e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 564368920    561 CQDSETRTFYQIGDSWEK-FVHGVRYQCYCYGRGIGEWHCQPLQT 604
Cdd:smart00058    1 CFDEETGTTYRVGDTWERpYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 470-513 5.71e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 67.76  E-value: 5.71e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 564368920    470 CTTNE-GVMYRIGDQWDKQHDLGHMMRCTCVGNGRGEWACIPYSQ 513
Cdd:smart00058    1 CFDEEtGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1542-1629 1.23e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 68.68  E-value: 1.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1542 DKPSQMQVTDVQDNSISVRWLPST---SPVTGYRVTTAPKNGLGPTKSQTVSPDQTEMTIEGLQPTVEYVVSVYAQNRNG 1618
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 564368920 1619 ESQPLVQTAVT 1629
Cdd:cd00063    82 ESPPSESVTVT 92
fn1 pfam00039
Fibronectin type I domain;
561-599 1.53e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 66.57  E-value: 1.53e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564368920   561 CQDSETRTFYQIGDSWEKFVH-GVRYQCYCYGRGIGEWHC 599
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQrGHVLQCTCLGNGGGEIRC 40
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1604-1974 1.70e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 75.81  E-value: 1.70e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1604 TVEYVVSVYAQNRNGESQPLVQTAVTNIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSS-PEDGIHELFPAPDGD 1682
Cdd:COG3401    21 TAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVaAAPPTATGLTTLTGS 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1683 EDTAELHGLRPGSEYTVSVVALHGGMESQPLIGVQSTAIPAPTNLKFTQVSPTTLTAQWTAPSVKLTGYRVRVTPKEKTG 1762
Cdd:COG3401   101 GSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAV 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1763 PMKEINLSPDSTSVIVSGLMVATKYEVSVYALKDTLTSRPAQGV--VTTLENVSPPRRARVTDATETTITISWRTKTET- 1839
Cdd:COG3401   181 ATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVsvTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESd 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1840 ITGFQVDAIPANGQTPVQRTiSPDVRSYTITGLQPGTDYKIHLYTLNDNARSSP--VVIDASTAI---DAPSNLRFLTTT 1914
Cdd:COG3401   261 ATGYRVYRSNSGDGPFTKVA-TVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESApsNVVSVTTDLtppAAPSGLTATAVG 339

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564368920 1915 PNSLLVSWQA-PRARITGYIIKYEKPGSPPREVVPRPRPGvTEATITGLEPGTEYTIYVIA 1974
Cdd:COG3401   340 SSSITLSWTAsSDADVTGYNVYRSTSGGGTYTKIAETVTT-TSYTDTGLTPGTTYYYKVTA 399
fn1 pfam00039
Fibronectin type I domain;
2085-2124 2.62e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 65.80  E-value: 2.62e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564368920  2085 CFDPYTVSHYAVGEEWERLSDSGFKLTCQCLGFGSGHFRC 2124
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 518-560 2.86e-13

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 65.84  E-value: 2.86e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 564368920    518 CIVDD--ITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPIDQ 560
Cdd:smart00058    1 CFDEEtgTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
470-508 4.40e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 65.03  E-value: 4.40e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564368920   470 CTTNE-GVMYRIGDQWDKQHDLGHMMRCTCVGNGRGEWAC 508
Cdd:pfam00039    1 CYDPQtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
fn3 pfam00041
Fibronectin type III domain;
907-987 5.77e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 66.28  E-value: 5.77e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920   907 PAPKDLQFVEVTDVKVTIMWTPP---NSAVTGYRVDVLPVNLpGEHGQRLPVNRNTF-AEVTGLSPGVTYLFKVFAVHQG 982
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNS-GEPWNEITVPGTTTsVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 564368920   983 RESKP 987
Cdd:pfam00041   80 GEGPP 84
fn1 pfam00039
Fibronectin type I domain;
187-226 1.38e-12

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 63.87  E-value: 1.38e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564368920   187 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGNGRITC 226
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 810-888 1.62e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.94  E-value: 1.62e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920    810 PDAPPDPTVDQVDDTSIVVRWSRPQ-----APITGYRIVYSPSvEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEE 884
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREE-GSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 564368920    885 NQES 888
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1267-1346 1.84e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.94  E-value: 1.84e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920   1267 PPPTDLRFTNIGPDTMRVTWAPPPSIELTNLLVRYSPVKNEED--VAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1344
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGseWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 564368920   1345 ES 1346
Cdd:smart00060   82 EG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 559-602 4.47e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 62.35  E-value: 4.47e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 564368920  559 DQCQDSETRTFYQIGDSWEKFVHGVRYQCYCYGrGIGEWHCQPL 602
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCDPV 43
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 98-141 7.25e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 61.98  E-value: 7.25e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 564368920     98 CFDKYTGNTYKVGDTYERPKDS-MIWDCTCIGAGRGRISCTIANR 141
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGgHVLQCTCLGGGRGEWKCDPVPV 45
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1903-1981 8.35e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.02  E-value: 8.35e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920   1903 DAPSNLRFLTTTPNSLLVSWQAP-RARITGYIIKY--EKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 1979
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYrvEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 564368920   1980 KS 1981
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
619-688 1.02e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 1.02e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564368920   619 TPSQPNSHPIQWNAPEP--SHITKYILRWRPKTSTGRWKEATIPGHLNSYTIKGLTPGVIYEGQLISIQQYG 688
Cdd:pfam00041    9 TDVTSTSLTVSWTPPPDgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2173-2212 1.08e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 61.19  E-value: 1.08e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 564368920 2173 TCYDD--GKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNC 2212
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDPV 43
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1542-1620 1.18e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 62.63  E-value: 1.18e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920   1542 DKPSQMQVTDVQDNSISVRWLP-----STSPVTGYRVTTAPKNGlgPTKSQTVSPDQTEMTIEGLQPTVEYVVSVYAQNR 1616
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPppddgITGYIVGYRVEYREEGS--EWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 564368920   1617 NGES 1620
Cdd:smart00060   80 AGEG 83
fn1 pfam00039
Fibronectin type I domain;
98-136 1.24e-11

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 61.18  E-value: 1.24e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564368920    98 CFDKYTGNTYKVGDTYERPKDS-MIWDCTCIGAGRGRISC 136
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRgHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 142-185 2.04e-11

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 60.44  E-value: 2.04e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 564368920    142 CHEG--GQSYKIGDKWRRPHEtGGYMLECLCLGNGKGEWTCKPIAE 185
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYE-GGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 96-137 2.31e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 60.42  E-value: 2.31e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 564368920   96 ETCFDKYTGNTYKVGDTYERPKDSMIWDCTCIGaGRGRISCT 137
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCD 41
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 907-994 2.39e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.13  E-value: 2.39e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  907 PAPKDLQFVEVTDVKVTIMWTPP---NSAVTGYRVDVLPVNLPGEHGQRLPVNRNTFAEVTGLSPGVTYLFKVFAVHQGR 983
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 564368920  984 ESKPLTAQQTT 994
Cdd:cd00063    82 ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1450-1526 2.88e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.48  E-value: 2.88e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920   1450 PRDLEVIASTPTSLLISWEPPAVS-----VRYYRITYGETGGNspVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRG 1524
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSE--WKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 564368920   1525 DS 1526
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1722-1809 5.43e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.97  E-value: 5.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1722 PAPTNLKFTQVSPTTLTAQWTAPS---VKLTGYRVRVTPKEKTGPMKEINLSPDSTSVIVSGLMVATKYEVSVYALKDTL 1798
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 564368920 1799 TSRPAQGVVTT 1809
Cdd:cd00063    82 ESPPSESVTVT 92
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 53-90 6.83e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 58.88  E-value: 6.83e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 564368920   53 CFDN--GKHYQINQQWERTYLGNALVCTCYGGSRGFNCES 90
Cdd:cd00061     3 CFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDP 42
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1632-1719 8.42e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.59  E-value: 8.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1632 DRPKGLAFTDVDVDSIKIAWESPQ---GQVSRYRVTYSSPEDGIHELFPAPDGDEDTAELHGLRPGSEYTVSVVALHGGM 1708
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 564368920 1709 ESQPLIGVQST 1719
Cdd:cd00063    82 ESPPSESVTVT 92
fn1 pfam00039
Fibronectin type I domain;
2130-2167 8.59e-11

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 58.48  E-value: 8.59e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564368920  2130 CHDN--GVNYKIGEKWDRQGENGQRMSCTCLGNGKGEFKC 2167
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2083-2127 9.43e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 58.50  E-value: 9.43e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 564368920 2083 DSCFDPYTVSHYAVGEEWERLSDsGFKLTCQCLGfGSGHFRCDSS 2127
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDPV 43
fn3 pfam00041
Fibronectin type III domain;
1632-1712 1.31e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.74  E-value: 1.31e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  1632 DRPKGLAFTDVDVDSIKIAWESP---QGQVSRYRVTYSSPEDGIHEL-FPAPdGDEDTAELHGLRPGSEYTVSVVALHGG 1707
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNeITVP-GTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 564368920  1708 MESQP 1712
Cdd:pfam00041   80 GEGPP 84
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 185-228 2.00e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 57.73  E-value: 2.00e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 564368920  185 EKCFDHAAGTSYVVGETWEKPYQGwMMVDCTCLGeGNGRITCTS 228
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEG-HVLQCTCLG-NRGEARCDP 42
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2174-2214 3.03e-10

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 57.36  E-value: 3.03e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 564368920   2174 CYDD--GKTYHVGEQWQKEYL-GAICSCTCFGGQRG-WRCDNCRR 2214
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
524-555 4.89e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 56.55  E-value: 4.89e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 564368920   524 TYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKC 555
Cdd:pfam00039    9 FYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 468-511 6.80e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 56.19  E-value: 6.80e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 564368920  468 EICTTNE-GVMYRIGDQWDKQHDlGHMMRCTCVGNgRGEWACIPY 511
Cdd:cd00061     1 EKCFDPQtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
fn1 pfam00039
Fibronectin type I domain;
142-180 9.61e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 55.78  E-value: 9.61e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 564368920   142 CHE--GGQSYKIGDKWRRPHETGgYMLECLCLGNGKGEWTC 180
Cdd:pfam00039    1 CYDpqTGRFYQVGETWERPSQRG-HVLQCTCLGNGGGEIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1814-1894 1.19e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 1.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1814 SPPRRARVTDATETTITISW---RTKTETITGFQVDAIPANGQTPVQ-RTISPDVRSYTITGLQPGTDYKIHLYTLNDNA 1889
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWtppEDDGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....*
gi 564368920 1890 RSSPV 1894
Cdd:cd00063    82 ESPPS 86
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 230-274 1.83e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 55.03  E-value: 1.83e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 564368920  230 NRCNDQDTRTSYRIGDTWSKKDNrGNLLQCVCTGNgRGEWKCERH 274
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 53-93 2.61e-09

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 54.66  E-value: 2.61e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 564368920     53 CFDN--GKHYQINQQWERTYL-GNALVCTCYGGSRG-FNCESKPE 93
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2129-2170 3.69e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 54.26  E-value: 3.69e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 564368920 2129 WCHDN--GVNYKIGEKWDRQGEnGQRMSCTCLGNgKGEFKCDPH 2170
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1722-1793 4.67e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.31  E-value: 4.67e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564368920   1722 PAPTNLKFTQVSPTTLTAQWTAPSVK-LTGYRV--RVTPKEKTGPMKEINLSPDSTSVIVSGLMVATKYEVSVYA 1793
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVgyRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 516-557 3.58e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 51.18  E-value: 3.58e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 564368920  516 DQCIVDD--ITYNVNDTFHKRHEeGHMLNCTCFGqGRGRWKCDP 557
Cdd:cd00061     1 EKCFDPQtgVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDP 42
fn1 pfam00039
Fibronectin type I domain;
2174-2209 6.72e-08

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 50.39  E-value: 6.72e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564368920  2174 CYDD--GKTYHVGEQWQKEYL-GAICSCTCFGGQRG-WRC 2209
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 140-182 9.63e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 50.02  E-value: 9.63e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 564368920  140 NRCHEG--GQSYKIGDKWRRPHEtgGYMLECLCLGNgKGEWTCKP 182
Cdd:cd00061     1 EKCFDPqtGVFYRVGETWERPSE--GHVLQCTCLGN-RGEARCDP 42
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1814-1888 1.89e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 1.89e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920   1814 SPPRRARVTDATETTITISWRTKTET-----ITGFQVDAIPANGQTpVQRTISPDVRSYTITGLQPGTDYKIHLYTLNDN 1888
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEW-KEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
fn1 pfam00039
Fibronectin type I domain;
53-88 2.27e-07

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 48.85  E-value: 2.27e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564368920    53 CFDN--GKHYQINQQWERTYL-GNALVCTCYGGSRG-FNC 88
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 907-985 4.10e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 4.10e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920    907 PAPKDLQFVEVTDVKVTIMWTPPNSAV-TGYRVDVLPVNLPGEHGQR--LPVNRNTFAEVTGLSPGVTYLFKVFAVHQGR 983
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGiTGYIVGYRVEYREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 564368920    984 ES 985
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
1999-2057 6.65e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 6.65e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564368920  1999 TISWT-PFQESSE---YIISCQPVGTDEEPLQFQVPGTSTSATLTGLTRGVTYNIIVEALHNQ 2057
Cdd:pfam00041   17 TVSWTpPPDGNGPitgYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1634-1710 4.33e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 4.33e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920   1634 PKGLAFTDVDVDSIKIAWESPQ-----GQVSRYRVTYSSPEDGIHELfpAPDGDEDTAELHGLRPGSEYTVSVVALHGGM 1708
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEV--NVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 564368920   1709 ES 1710
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 616-688 8.83e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 8.83e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564368920    616 ITETPSQPNSHPIQWNAPEPSHITKYILRWRP--KTSTGRWKEATIPGHLNSYTIKGLTPGVIYEGQLISIQQYG 688
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVeyREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 611-678 8.40e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.25  E-value: 8.40e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  611 PVQVIITETpsQPNSHPIQWNAPEP--SHITKYILRWRPKTSTGRWKEATIPGHLNSYTIKGLTPGVIYE 678
Cdd:cd00063     4 PTNLRVTDV--TSTSVTLSWTPPEDdgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYE 71
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 308-347 1.42e-04

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 41.18  E-value: 1.42e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 564368920    308 CVTD-SGVVYSVGMQWLK-SQGDKQMLCTCLGNG---VSCQETAV 347
Cdd:smart00058    1 CFDEeTGTTYRVGDTWERpYEGGHVLQCTCLGGGrgeWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 307-345 2.05e-04

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 40.78  E-value: 2.05e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 564368920  307 HCVTDS-GVVYSVGMQWLKSQGDKQMLCTCLGN--GVSCQET 345
Cdd:cd00061     2 KCFDPQtGVFYRVGETWERPSEGHVLQCTCLGNrgEARCDPV 43
 
Name Accession Description Interval E-value
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 353-401 5.85e-24

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 96.21  E-value: 5.85e-24
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 564368920    353 GNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 413-461 2.18e-23

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 94.67  E-value: 2.18e-23
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 564368920    413 GNSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 354-401 2.19e-22

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 91.98  E-value: 2.19e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 564368920  354 NSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:cd00062     1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 414-461 2.71e-22

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 91.60  E-value: 2.71e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 564368920  414 NSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:cd00062     1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
fn2 pfam00040
Fibronectin type II domain;
360-401 2.17e-20

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 86.08  E-value: 2.17e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 564368920   360 CVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
fn3 pfam00041
Fibronectin type III domain;
1448-1529 1.33e-19

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 85.16  E-value: 1.33e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  1448 DVPRDLEVIASTPTSLLISWEPPAVS---VRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRG 1524
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 564368920  1525 DSPAS 1529
Cdd:pfam00041   81 EGPPS 85
fn3 pfam00041
Fibronectin type III domain;
1542-1622 3.69e-19

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 84.00  E-value: 3.69e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  1542 DKPSQMQVTDVQDNSISVRWLPST---SPVTGYRVTTAPKNGLGPTKSQTVSPDQTEMTIEGLQPTVEYVVSVYAQNRNG 1618
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 564368920  1619 ESQP 1622
Cdd:pfam00041   81 EGPP 84
fn2 pfam00040
Fibronectin type II domain;
420-461 4.91e-19

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 82.23  E-value: 4.91e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 564368920   420 CHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
993-1537 1.10e-17

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 89.29  E-value: 1.10e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  993 TTKLDAPTNLQFVNETDRTVLVTWTPPRARIAGYRLTVGLTRGGQPKQYNVGPMASKYPLRNLQPG--SEYTVTLMAVKG 1070
Cdd:COG3401    54 TLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSpaVGTATTATAVAG 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1071 NQQSPKATGVFTTLQPLRSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGgeapreVTSDSGSIVVSGLTPGVEYTY 1150
Cdd:COG3401   134 GAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLT------VTSTTLVDGGGDIEPGTTYYY 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1151 TIQVLRDGQERDAPIVNRVV---TPLSPPTNLHLEANPDTGVlTVSWERSTTPDITGYRITTTPTNGQQGTALEEVvhaD 1227
Cdd:COG3401   208 RVAATDTGGESAPSNEVSVTtptTPPSAPTGLTATADTPGSV-TLSWDPVTESDATGYRVYRSNSGDGPFTKVATV---T 283

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1228 QSSCTFENLNPGLEYNVSVYTVKDDKESAPISDTV-----IPAVPPPTDLRFTNIGPDTMRVTWAPPPSIELTNLLVrYS 1302
Cdd:COG3401   284 TTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVsvttdLTPPAAPSGLTATAVGSSSITLSWTASSDADVTGYNV-YR 362

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1303 PVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVY---------EQHESIPLRGRQKTGLDSPTGFDSSDVTANSF 1373
Cdd:COG3401   363 STSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDaagnesapsEEVSATTASAASGESLTASVDAVPLTDVAGAT 442

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1374 TVHWVAPRAPITGYIIRH-HAEHSAGRPRQDRVppsrNSITLTNLNPGTEYIVTIIAVNGREESPPLIGQQSTVSDVPRD 1452
Cdd:COG3401   443 AAASAASNPGVSAAVLADgGDTGNAVPFTTTSS----TVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAA 518

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1453 LEVIASTPTSLLISWEPPAVSVRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDSPASSKP 1532
Cdd:COG3401   519 AVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSGAGLGSGNLYLITTLGGSLLTTTSTNTNDVAGVHGG 598


                  ....*
gi 564368920 1533 VSINY 1537
Cdd:COG3401   599 TLLVL 603
fn3 pfam00041
Fibronectin type III domain;
1358-1438 1.01e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 77.07  E-value: 1.01e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  1358 DSPTGFDSSDVTANSFTVHWVAPR---APITGYIIRHHAEHSAGRPRQDRVPPSRNSITLTNLNPGTEYIVTIIAVNGRE 1434
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 564368920  1435 ESPP 1438
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1903-1983 1.04e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.15  E-value: 1.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1903 DAPSNLRFLTTTPNSLLVSWQAPR---ARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 1979
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 564368920 1980 KSEP 1983
Cdd:cd00063    82 ESPP 85
fn3 pfam00041
Fibronectin type III domain;
811-882 8.67e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 74.37  E-value: 8.67e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564368920   811 DAPPDPTVDQVDDTSIVVRWSRP---QAPITGYRIVYSPSVEGS-STELNLPETANSVTLSDLQPGVQYNITIYAV 882
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
fn3 pfam00041
Fibronectin type III domain;
1722-1802 1.06e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.99  E-value: 1.06e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  1722 PAPTNLKFTQVSPTTLTAQWTAP---SVKLTGYRVRVTPKEKTGPMKEINLSPDSTSVIVSGLMVATKYEVSVYALKDTL 1798
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 564368920  1799 TSRP 1802
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
1267-1348 1.76e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.60  E-value: 1.76e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  1267 PPPTDLRFTNIGPDTMRVTWAPPP--SIELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1344
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 564368920  1345 ESIP 1348
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
1903-1983 2.19e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.22  E-value: 2.19e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  1903 DAPSNLRFLTTTPNSLLVSWQAPRAR---ITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 1979
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 564368920  1980 KSEP 1983
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 810-898 2.73e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 73.30  E-value: 2.73e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  810 PDAPPDPTVDQVDDTSIVVRWSRPQ---APITGYRIVYSPSVEGSSTELNLPE-TANSVTLSDLQPGVQYNITIYAVEEN 885
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 564368920  886 QESTPVFIQQETT 898
Cdd:cd00063    81 GESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
698-1033 5.71e-15

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 80.82  E-value: 5.71e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  698 TTSASTPVTSNTVTGETAPFSPVVATSESVTEITASSFVVSWVSASDT-VSGFRVEYELSEEGdEPQYLDlPSTATSVNI 776
Cdd:COG3401   212 TDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDG-PFTKVA-TVTTTSYTD 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  777 PDLLPGRKY---IVNVYQISEEGKQSLILS-TSQTTAPDAPPDPTVDQVDDTSIVVRWS-RPQAPITGYRIVYSPSVEGS 851
Cdd:COG3401   290 TGLTNGTTYyyrVTAVDAAGNESAPSNVVSvTTDLTPPAAPSGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGT 369

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  852 STELNLPETANSVTLSDLQPGVQYNITIYAV----EENQESTPVFIQQETTGVPRSDDVPAPKDLQFVEVTDVKVTIMWT 927
Cdd:COG3401   370 YTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdaagNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAAS 449

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  928 PPNSAVTGYRVDVLPVNLPgehgqrlPVNRNTFAEVTGLSPGVTYLFKVFAVHQGRESKPLTAQQTTKLDAPTNLQFVNE 1007
Cdd:COG3401   450 NPGVSAAVLADGGDTGNAV-------PFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGG 522

                         330       340
                  ....*....|....*....|....*.
gi 564368920 1008 TDRTVLVTWTPPRARIAGYRLTVGLT 1033
Cdd:COG3401   523 APDGTPNVTGASPVTVGASTGDVLIT 548
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 187-231 6.29e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 70.46  E-value: 6.29e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 564368920    187 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGNGRITCTSRNR 231
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
232-271 1.42e-14

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 69.26  E-value: 1.42e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564368920   232 CNDQDTRTSYRIGDTWSKKDNRGNLLQCVCTGNGRGEWKC 271
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1358-1438 1.86e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.99  E-value: 1.86e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1358 DSPTGFDSSDVTANSFTVHWVAPR---APITGYIIRHHAEHSAGRPRQDRVPPSRNSITLTNLNPGTEYIVTIIAVNGRE 1434
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 564368920 1435 ESPP 1438
Cdd:cd00063    82 ESPP 85
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2130-2171 1.93e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.30  E-value: 1.93e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 564368920   2130 CHDN--GVNYKIGEKWDRQGENGQRMSCTCLGNGKGEFKCDPHE 2171
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVP 44
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2085-2129 1.99e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.92  E-value: 1.99e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 564368920   2085 CFDPYTVSHYAVGEEWERLSDSGFKLTCQCLGFGSGHFRCDSSKW 2129
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 232-274 3.21e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.53  E-value: 3.21e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 564368920    232 CNDQDTRTSYRIGDTWSKKDNRGNLLQCVCTGNGRGEWKCERH 274
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPV 43
fn3 pfam00041
Fibronectin type III domain;
1814-1893 4.27e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.37  E-value: 4.27e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  1814 SPPRRARVTDATETTITISWRTKTE---TITGFQVDAIPANGQTPVQ-RTISPDVRSYTITGLQPGTDYKIHLYTLNDNA 1889
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNeITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 564368920  1890 RSSP 1893
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1448-1530 4.51e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.83  E-value: 4.51e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1448 DVPRDLEVIASTPTSLLISWEPPAVS---VRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRG 1524
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....*.
gi 564368920 1525 DSPASS 1530
Cdd:cd00063    82 ESPPSE 87
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 561-604 4.65e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.15  E-value: 4.65e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 564368920    561 CQDSETRTFYQIGDSWEK-FVHGVRYQCYCYGRGIGEWHCQPLQT 604
Cdd:smart00058    1 CFDEETGTTYRVGDTWERpYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 470-513 5.71e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 67.76  E-value: 5.71e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 564368920    470 CTTNE-GVMYRIGDQWDKQHDLGHMMRCTCVGNGRGEWACIPYSQ 513
Cdd:smart00058    1 CFDEEtGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1166-1576 6.61e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 77.35  E-value: 6.61e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1166 VNRVVTPLSPPTNLHLEANPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGTALEEVVHADQSSCTFENLNPGLEYNVS 1245
Cdd:COG3401    43 VLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAV 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1246 VYTVKDDKESAPISDTVIPAVPPPTDLRFTNIGPDTMRVTWAPPpsielTNLLVRYSPVKNEEDVAELSISPSDNAVVLT 1325
Cdd:COG3401   123 GTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGA-----GVVVSPDTSATAAVATTSLTVTSTTLVDGGG 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1326 NLLPGTEYLVSVSSVYEQHESIPLRGRQKTGL----DSPTGFDSSDVTANSFTVHWVAPRAP-ITGYIIrHHAEHSAGRP 1400
Cdd:COG3401   198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPttppSAPTGLTATADTPGSVTLSWDPVTESdATGYRV-YRSNSGDGPF 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1401 RQdRVPPSRNSITLTNLNPGTEYIVTIIAVNGR-EESPPligqqSTVSDV---------PRDLEVIASTPTSLLISWEPP 1470
Cdd:COG3401   277 TK-VATVTTTSYTDTGLTNGTTYYYRVTAVDAAgNESAP-----SNVVSVttdltppaaPSGLTATAVGSSSITLSWTAS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1471 A-VSVRYYRItYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDSPASSKPVSINYQTEIDKPSQMQV 1549
Cdd:COG3401   351 SdADVTGYNV-YRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTAS 429

                         410       420
                  ....*....|....*....|....*..
gi 564368920 1550 TDVQDNSISVRWLPSTSPVTGYRVTTA 1576
Cdd:COG3401   430 VDAVPLTDVAGATAAASAASNPGVSAA 456
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1542-1629 1.23e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 68.68  E-value: 1.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1542 DKPSQMQVTDVQDNSISVRWLPST---SPVTGYRVTTAPKNGLGPTKSQTVSPDQTEMTIEGLQPTVEYVVSVYAQNRNG 1618
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 564368920 1619 ESQPLVQTAVT 1629
Cdd:cd00063    82 ESPPSESVTVT 92
fn1 pfam00039
Fibronectin type I domain;
561-599 1.53e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 66.57  E-value: 1.53e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564368920   561 CQDSETRTFYQIGDSWEKFVH-GVRYQCYCYGRGIGEWHC 599
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQrGHVLQCTCLGNGGGEIRC 40
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1604-1974 1.70e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 75.81  E-value: 1.70e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1604 TVEYVVSVYAQNRNGESQPLVQTAVTNIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSS-PEDGIHELFPAPDGD 1682
Cdd:COG3401    21 TAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVaAAPPTATGLTTLTGS 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1683 EDTAELHGLRPGSEYTVSVVALHGGMESQPLIGVQSTAIPAPTNLKFTQVSPTTLTAQWTAPSVKLTGYRVRVTPKEKTG 1762
Cdd:COG3401   101 GSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAV 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1763 PMKEINLSPDSTSVIVSGLMVATKYEVSVYALKDTLTSRPAQGV--VTTLENVSPPRRARVTDATETTITISWRTKTET- 1839
Cdd:COG3401   181 ATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVsvTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESd 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1840 ITGFQVDAIPANGQTPVQRTiSPDVRSYTITGLQPGTDYKIHLYTLNDNARSSP--VVIDASTAI---DAPSNLRFLTTT 1914
Cdd:COG3401   261 ATGYRVYRSNSGDGPFTKVA-TVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESApsNVVSVTTDLtppAAPSGLTATAVG 339

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564368920 1915 PNSLLVSWQA-PRARITGYIIKYEKPGSPPREVVPRPRPGvTEATITGLEPGTEYTIYVIA 1974
Cdd:COG3401   340 SSSITLSWTAsSDADVTGYNVYRSTSGGGTYTKIAETVTT-TSYTDTGLTPGTTYYYKVTA 399
fn1 pfam00039
Fibronectin type I domain;
2085-2124 2.62e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 65.80  E-value: 2.62e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564368920  2085 CFDPYTVSHYAVGEEWERLSDSGFKLTCQCLGFGSGHFRC 2124
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 518-560 2.86e-13

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 65.84  E-value: 2.86e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 564368920    518 CIVDD--ITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPIDQ 560
Cdd:smart00058    1 CFDEEtgTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
470-508 4.40e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 65.03  E-value: 4.40e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564368920   470 CTTNE-GVMYRIGDQWDKQHDLGHMMRCTCVGNGRGEWAC 508
Cdd:pfam00039    1 CYDPQtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
fn3 pfam00041
Fibronectin type III domain;
907-987 5.77e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 66.28  E-value: 5.77e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920   907 PAPKDLQFVEVTDVKVTIMWTPP---NSAVTGYRVDVLPVNLpGEHGQRLPVNRNTF-AEVTGLSPGVTYLFKVFAVHQG 982
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNS-GEPWNEITVPGTTTsVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 564368920   983 RESKP 987
Cdd:pfam00041   80 GEGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
807-1379 1.07e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 73.50  E-value: 1.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  807 TTAPDAPPDPTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQ 886
Cdd:COG3401    54 TLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAG 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  887 ESTPVFIQQETTGVPRSDDVPAPKDLQFVEVTDVKVTIMWTPPNSAVTGYRVDVLPVNLPGEHGqrlpvnrntfaevtGL 966
Cdd:COG3401   134 GAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGG--------------DI 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  967 SPGVTYLFKVFAVHQGRESKP----LTAQQTTKLDAPTNLQFVNETDRTVLVTWTP-PRARIAGYRLtvgltrggqpkqy 1041
Cdd:COG3401   200 EPGTTYYYRVAATDTGGESAPsnevSVTTPTTPPSAPTGLTATADTPGSVTLSWDPvTESDATGYRV------------- 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1042 nvgpmaskyplrnlqpgseytvtlmavkgnQQSPKATGVFTTLqplrsippynTEVTETtivitwtpaprigfklgvrps 1121
Cdd:COG3401   267 ------------------------------YRSNSGDGPFTKV----------ATVTTT--------------------- 285

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1122 qggeaprevtsdsgSIVVSGLTPGVEYTYTIQVLRDGQERDAP----IVNRVVTPLSPPTNLHLEANPDTGVlTVSWERS 1197
Cdd:COG3401   286 --------------SYTDTGLTNGTTYYYRVTAVDAAGNESAPsnvvSVTTDLTPPAAPSGLTATAVGSSSI-TLSWTAS 350

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1198 TTPDITGYRITTTPTNGQQGTALEEVVhaDQSSCTFENLNPGLEYNVSVYTV-KDDKESAPISDTVIPAVPPPTDLRFTN 1276
Cdd:COG3401   351 SDADVTGYNVYRSTSGGGTYTKIAETV--TTTSYTDTGLTPGTTYYYKVTAVdAAGNESAPSEEVSATTASAASGESLTA 428

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1277 iGPDTMRVTWAPPPSIELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQHESIPLRGRQKTG 1356
Cdd:COG3401   429 -SVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTN 507

                         570       580
                  ....*....|....*....|...
gi 564368920 1357 LDSPTGFDSSDVTANSFTVHWVA 1379
Cdd:COG3401   508 SVSVIGASAAAAVGGAPDGTPNV 530
fn1 pfam00039
Fibronectin type I domain;
187-226 1.38e-12

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 63.87  E-value: 1.38e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564368920   187 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGNGRITC 226
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
fn3 pfam00041
Fibronectin type III domain;
1174-1257 1.56e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.13  E-value: 1.56e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  1174 SPPTNLHL-EANPDTgvLTVSWERSTTP--DITGYRITTTPTNGQQGTaLEEVVHADQSSCTFENLNPGLEYNVSVYTVK 1250
Cdd:pfam00041    1 SAPSNLTVtDVTSTS--LTVSWTPPPDGngPITGYEVEYRPKNSGEPW-NEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   ....*..
gi 564368920  1251 DDKESAP 1257
Cdd:pfam00041   78 GGGEGPP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 810-888 1.62e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.94  E-value: 1.62e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920    810 PDAPPDPTVDQVDDTSIVVRWSRPQ-----APITGYRIVYSPSvEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEE 884
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREE-GSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 564368920    885 NQES 888
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1267-1346 1.84e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.94  E-value: 1.84e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920   1267 PPPTDLRFTNIGPDTMRVTWAPPPSIELTNLLVRYSPVKNEED--VAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1344
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGseWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 564368920   1345 ES 1346
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
726-797 3.44e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 3.44e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564368920   726 SVTEITASSFVVSW---VSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEEGK 797
Cdd:pfam00041    7 TVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 559-602 4.47e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 62.35  E-value: 4.47e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 564368920  559 DQCQDSETRTFYQIGDSWEKFVHGVRYQCYCYGrGIGEWHCQPL 602
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCDPV 43
fn3 pfam00041
Fibronectin type III domain;
997-1075 4.47e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.59  E-value: 4.47e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920   997 DAPTNLQFVNETDRTVLVTWTPPRAR---IAGYRLTVGLTRGGQPKQ-YNVGPMASKYPLRNLQPGSEYTVTLMAVKGNQ 1072
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNeITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ...
gi 564368920  1073 QSP 1075
Cdd:pfam00041   81 EGP 83
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 98-141 7.25e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 61.98  E-value: 7.25e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 564368920     98 CFDKYTGNTYKVGDTYERPKDS-MIWDCTCIGAGRGRISCTIANR 141
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGgHVLQCTCLGGGRGEWKCDPVPV 45
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1903-1981 8.35e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.02  E-value: 8.35e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920   1903 DAPSNLRFLTTTPNSLLVSWQAP-RARITGYIIKY--EKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 1979
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYrvEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 564368920   1980 KS 1981
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
619-688 1.02e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 1.02e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564368920   619 TPSQPNSHPIQWNAPEP--SHITKYILRWRPKTSTGRWKEATIPGHLNSYTIKGLTPGVIYEGQLISIQQYG 688
Cdd:pfam00041    9 TDVTSTSLTVSWTPPPDgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1267-1348 1.03e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.90  E-value: 1.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1267 PPPTDLRFTNIGPDTMRVTWAPPPSI--ELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1344
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 564368920 1345 ESIP 1348
Cdd:cd00063    82 ESPP 85
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2173-2212 1.08e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 61.19  E-value: 1.08e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 564368920 2173 TCYDD--GKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNC 2212
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDPV 43
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1542-1620 1.18e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 62.63  E-value: 1.18e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920   1542 DKPSQMQVTDVQDNSISVRWLP-----STSPVTGYRVTTAPKNGlgPTKSQTVSPDQTEMTIEGLQPTVEYVVSVYAQNR 1616
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPppddgITGYIVGYRVEYREEGS--EWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 564368920   1617 NGES 1620
Cdd:smart00060   80 AGEG 83
fn1 pfam00039
Fibronectin type I domain;
98-136 1.24e-11

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 61.18  E-value: 1.24e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564368920    98 CFDKYTGNTYKVGDTYERPKDS-MIWDCTCIGAGRGRISC 136
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRgHVLQCTCLGNGGGEIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 997-1083 1.35e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.51  E-value: 1.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  997 DAPTNLQFVNETDRTVLVTWTPPR---ARIAGYRLTVGLTRGGQPKQYNVGPM-ASKYPLRNLQPGSEYTVTLMAVKGNQ 1072
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGsETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 564368920 1073 QSPKATGV-FTT 1083
Cdd:cd00063    82 ESPPSESVtVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1358-1436 2.01e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.86  E-value: 2.01e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920   1358 DSPTGFDSSDVTANSFTVHWVAPRAP-ITGYIIRHHAEHSAGRPRQDRV--PPSRNSITLTNLNPGTEYIVTIIAVNGRE 1434
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 564368920   1435 ES 1436
Cdd:smart00060   82 EG 83
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 142-185 2.04e-11

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 60.44  E-value: 2.04e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 564368920    142 CHEG--GQSYKIGDKWRRPHEtGGYMLECLCLGNGKGEWTCKPIAE 185
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYE-GGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 96-137 2.31e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 60.42  E-value: 2.31e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 564368920   96 ETCFDKYTGNTYKVGDTYERPKDSMIWDCTCIGaGRGRISCT 137
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCD 41
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 907-994 2.39e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.13  E-value: 2.39e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  907 PAPKDLQFVEVTDVKVTIMWTPP---NSAVTGYRVDVLPVNLPGEHGQRLPVNRNTFAEVTGLSPGVTYLFKVFAVHQGR 983
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 564368920  984 ESKPLTAQQTT 994
Cdd:cd00063    82 ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1450-1526 2.88e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.48  E-value: 2.88e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920   1450 PRDLEVIASTPTSLLISWEPPAVS-----VRYYRITYGETGGNspVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRG 1524
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSE--WKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 564368920   1525 DS 1526
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1722-1809 5.43e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.97  E-value: 5.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1722 PAPTNLKFTQVSPTTLTAQWTAPS---VKLTGYRVRVTPKEKTGPMKEINLSPDSTSVIVSGLMVATKYEVSVYALKDTL 1798
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 564368920 1799 TSRPAQGVVTT 1809
Cdd:cd00063    82 ESPPSESVTVT 92
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 53-90 6.83e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 58.88  E-value: 6.83e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 564368920   53 CFDN--GKHYQINQQWERTYLGNALVCTCYGGSRGFNCES 90
Cdd:cd00061     3 CFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDP 42
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1632-1719 8.42e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.59  E-value: 8.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1632 DRPKGLAFTDVDVDSIKIAWESPQ---GQVSRYRVTYSSPEDGIHELFPAPDGDEDTAELHGLRPGSEYTVSVVALHGGM 1708
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 564368920 1709 ESQPLIGVQST 1719
Cdd:cd00063    82 ESPPSESVTVT 92
fn1 pfam00039
Fibronectin type I domain;
2130-2167 8.59e-11

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 58.48  E-value: 8.59e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564368920  2130 CHDN--GVNYKIGEKWDRQGENGQRMSCTCLGNGKGEFKC 2167
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2083-2127 9.43e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 58.50  E-value: 9.43e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 564368920 2083 DSCFDPYTVSHYAVGEEWERLSDsGFKLTCQCLGfGSGHFRCDSS 2127
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDPV 43
fn3 pfam00041
Fibronectin type III domain;
1632-1712 1.31e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.74  E-value: 1.31e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  1632 DRPKGLAFTDVDVDSIKIAWESP---QGQVSRYRVTYSSPEDGIHEL-FPAPdGDEDTAELHGLRPGSEYTVSVVALHGG 1707
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNeITVP-GTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 564368920  1708 MESQP 1712
Cdd:pfam00041   80 GEGPP 84
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 185-228 2.00e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 57.73  E-value: 2.00e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 564368920  185 EKCFDHAAGTSYVVGETWEKPYQGwMMVDCTCLGeGNGRITCTS 228
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEG-HVLQCTCLG-NRGEARCDP 42
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2174-2214 3.03e-10

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 57.36  E-value: 3.03e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 564368920   2174 CYDD--GKTYHVGEQWQKEYL-GAICSCTCFGGQRG-WRCDNCRR 2214
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1041-1618 3.92e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 65.02  E-value: 3.92e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1041 YNVGPMASKYPLRNLQPGSEYTVTLMAVKGNQQSPKATGVFTTLQPLRSIPPYNTEVT-ETTIVITWTPAPRIGFKLGVR 1119
Cdd:COG3401     1 TGSSYLTSLDAGIAASAAANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAaGLSSGGGLGTGGRAGTTSGVA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1120 PSQGGEAPREVTSDSGSIVVSGLTPGVEYTYTIQVLRDGQERDAPIVNRVVTPLSPPTNLHLEANPDTGVlTVSWERSTT 1199
Cdd:COG3401    81 AVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGV-DGANASGTT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1200 PDITGYRITTTPTNGQQGTALEEVVHADQSSCT---FENLNPGLEYNVSVYTVKDDKESAP---ISDTVIPAVP-PPTDL 1272
Cdd:COG3401   160 ASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLvdgGGDIEPGTTYYYRVAATDTGGESAPsneVSVTTPTTPPsAPTGL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1273 RFTNIGPDTMRVTWAPPPSIELTNLLVRYSPVKNE--EDVAELSispsDNAVVLTNLLPGTEYLVSVSSVYEQHESIPLR 1350
Cdd:COG3401   240 TATADTPGSVTLSWDPVTESDATGYRVYRSNSGDGpfTKVATVT----TTSYTDTGLTNGTTYYYRVTAVDAAGNESAPS 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1351 G-----RQKTGLDSPTGFDSSDVTANSFTVHW-VAPRAPITGYIIrHHAEHSAGRPRQDRVPPSRNSITLTNLNPGTEYI 1424
Cdd:COG3401   316 NvvsvtTDLTPPAAPSGLTATAVGSSSITLSWtASSDADVTGYNV-YRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYY 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1425 --VTIIAVNGREE--SPPLIGQQSTVSDVPRDLEVIASTPTSLLISWEPPAVSVRYYRITYGETGGNSPVQEFTVPGSKS 1500
Cdd:COG3401   395 ykVTAVDAAGNESapSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTS 474

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1501 TATINNIKPGADYTITLYAVTGRGDSPASSKPVSINYQTEIDKPSQMQVTDVQDNSISVrwlpSTSPVTGYRVTTAPKNG 1580
Cdd:COG3401   475 STVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGA----SPVTVGASTGDVLITDL 550

                         570       580       590
                  ....*....|....*....|....*....|....*...
gi 564368920 1581 LGPTKSQTVSPDQTEMTIEGLQPTVEYVVSVYAQNRNG 1618
Cdd:COG3401   551 VSLTTSASSSVSGAGLGSGNLYLITTLGGSLLTTTSTN 588
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1174-1263 4.77e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.28  E-value: 4.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1174 SPPTNLHLEANPDTGVlTVSWERSTTP--DITGYRITTTPTNGQQGTALEeVVHADQSSCTFENLNPGLEYNVSVYTVKD 1251
Cdd:cd00063     2 SPPTNLRVTDVTSTSV-TLSWTPPEDDggPITGYVVEYREKGSGDWKEVE-VTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|..
gi 564368920 1252 DKESAPISDTVI 1263
Cdd:cd00063    80 GGESPPSESVTV 91
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
563-956 4.85e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 64.64  E-value: 4.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  563 DSETRTFYQIGDSWEKFVHGVRYQCY--CYGRGIGEWHCQPLQTYPGTTGPVQVI-ITETPSQPNSHPIQWNAPEPSHIT 639
Cdd:COG3401   183 TSLTVTSTTLVDGGGDIEPGTTYYYRvaATDTGGESAPSNEVSVTTPTTPPSAPTgLTATADTPGSVTLSWDPVTESDAT 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  640 KYILrWRPKTSTGRWKE-ATIPGhlNSYTIKGLTPGVIYEgqlisiqqYGhqeVTRFDFTTSASTPvtSNTVTGETAPFS 718
Cdd:COG3401   263 GYRV-YRSNSGDGPFTKvATVTT--TSYTDTGLTNGTTYY--------YR---VTAVDAAGNESAP--SNVVSVTTDLTP 326

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  719 PVVATSESVTEITASSFVVSWVSASDT-VSGFRVEYELSEEGdEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEEGK 797
Cdd:COG3401   327 PAAPSGLTATAVGSSSITLSWTASSDAdVTGYNVYRSTSGGG-TYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGN 405

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  798 QSLILSTSQTTAPDAPPDPTVDQVDDTSIVVRWSRPQAPI--------------TGYRIVYSPSVEGSSTELNLPETANS 863
Cdd:COG3401   406 ESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAAsaasnpgvsaavlaDGGDTGNAVPFTTTSSTVTATTTDTT 485

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  864 VTLSDLQPGVQYNITIYAVEENQESTPVF-IQQETTGVPRSDDVPAPKDLQFVEVTDVKVTIMWTPPNSAVTGYRVDVLP 942
Cdd:COG3401   486 TANLSVTTGSLVGGSGASSVTNSVSVIGAsAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSGAG 565

                         410
                  ....*....|....
gi 564368920  943 VNLPGEHGQRLPVN 956
Cdd:COG3401   566 LGSGNLYLITTLGG 579
fn1 pfam00039
Fibronectin type I domain;
524-555 4.89e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 56.55  E-value: 4.89e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 564368920   524 TYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKC 555
Cdd:pfam00039    9 FYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 468-511 6.80e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 56.19  E-value: 6.80e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 564368920  468 EICTTNE-GVMYRIGDQWDKQHDlGHMMRCTCVGNgRGEWACIPY 511
Cdd:cd00061     1 EKCFDPQtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
fn1 pfam00039
Fibronectin type I domain;
142-180 9.61e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 55.78  E-value: 9.61e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 564368920   142 CHE--GGQSYKIGDKWRRPHETGgYMLECLCLGNGKGEWTC 180
Cdd:pfam00039    1 CYDpqTGRFYQVGETWERPSQRG-HVLQCTCLGNGGGEIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1814-1894 1.19e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 1.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1814 SPPRRARVTDATETTITISW---RTKTETITGFQVDAIPANGQTPVQ-RTISPDVRSYTITGLQPGTDYKIHLYTLNDNA 1889
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWtppEDDGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....*
gi 564368920 1890 RSSPV 1894
Cdd:cd00063    82 ESPPS 86
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
704-898 1.47e-09

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 63.43  E-value: 1.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  704 PVTSNTVTGETAPFSPVVATSESVTEITassfvVSWVSASDTVSgfrveYELSEEGDEPQYLDLPST-ATSVNIPDLLPG 782
Cdd:COG4733   528 PPQWPPVNVTTSESLSVVAQGTAVTTLT-----VSWDAPAGAVA-----YEVEWRRDDGNWVSVPRTsGTSFEVPGIYAG 597

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  783 RkYIVNVYQISEEGKQSLILSTSQTTA---PDAPPDPTVDQV--DDTSIVVRWSRPQ-APITGYRIVYSPSVEGSSTELN 856
Cdd:COG4733   598 D-YEVRVRAINALGVSSAWAASSETTVtgkTAPPPAPTGLTAtgGLGGITLSWSFPVdADTLRTEIRYSTTGDWASATVA 676

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 564368920  857 LPE-TANSVTLSDLQPGVQYNITIYAVEENQESTPVFIQQETT 898
Cdd:COG4733   677 QALyPGNTYTLAGLKAGQTYYYRARAVDRSGNVSAWWVSGQAS 719
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1733-2105 1.75e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 63.10  E-value: 1.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1733 SPTTLTAQWTAPSVKLTGYRVRVTPKEKTGPMKEINLSPDSTSVIVSGLMVATKYEVSVYALKDTLTSRPAQGVVTTLEN 1812
Cdd:COG3401    75 TTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGAN 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1813 VSPPRRARVTDATETTITISWRTKTETITGFqvdaipangqtpvqrTISPDVRSYTITGLQPGTDYKIHLYTLNDNARSS 1892
Cdd:COG3401   155 ASGTTASSVAGAGVVVSPDTSATAAVATTSL---------------TVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESA 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1893 PV----VIDASTAIDAPSNLRFLTTTPNSLLVSWQA-PRARITGYIIKYEKPGSPPREVVPRPRpgVTEATITGLEPGTE 1967
Cdd:COG3401   220 PSnevsVTTPTTPPSAPTGLTATADTPGSVTLSWDPvTESDATGYRVYRSNSGDGPFTKVATVT--TTSYTDTGLTNGTT 297

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1968 YTIYVIALKNN----QKSEPLIGrkKTGQEAL-------------SQTTISWTPFQES--SEYIIscqpVGTDEEPLQFQ 2028
Cdd:COG3401   298 YYYRVTAVDAAgnesAPSNVVSV--TTDLTPPaapsgltatavgsSSITLSWTASSDAdvTGYNV----YRSTSGGGTYT 371

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 2029 V---PGTSTSATLTGLTRGVTYNIIVEALHNQRRHKVREEVVTVGNTVNEGLNQPTDDSCFDPYTVSHYAVGEEWERLSD 2105
Cdd:COG3401   372 KiaeTVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNP 451
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 230-274 1.83e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 55.03  E-value: 1.83e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 564368920  230 NRCNDQDTRTSYRIGDTWSKKDNrGNLLQCVCTGNgRGEWKCERH 274
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 53-93 2.61e-09

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 54.66  E-value: 2.61e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 564368920     53 CFDN--GKHYQINQQWERTYL-GNALVCTCYGGSRG-FNCESKPE 93
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2129-2170 3.69e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 54.26  E-value: 3.69e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 564368920 2129 WCHDN--GVNYKIGEKWDRQGEnGQRMSCTCLGNgKGEFKCDPH 2170
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1722-1793 4.67e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.31  E-value: 4.67e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564368920   1722 PAPTNLKFTQVSPTTLTAQWTAPSVK-LTGYRV--RVTPKEKTGPMKEINLSPDSTSVIVSGLMVATKYEVSVYA 1793
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVgyRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 997-1074 7.24e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.54  E-value: 7.24e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920    997 DAPTNLQFVNETDRTVLVTWTPP-----RARIAGYRLtVGLTRGGQPKQYNVGPMASKYPLRNLQPGSEYTVTLMAVKGN 1071
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRV-EYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 564368920   1072 QQS 1074
Cdd:smart00060   81 GEG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 516-557 3.58e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 51.18  E-value: 3.58e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 564368920  516 DQCIVDD--ITYNVNDTFHKRHEeGHMLNCTCFGqGRGRWKCDP 557
Cdd:cd00061     1 EKCFDPQtgVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDP 42
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1174-1255 3.70e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.62  E-value: 3.70e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920   1174 SPPTNLHLEANPDTGVlTVSWERSTTPDITGYRITTTPTNGQQGTALEEV-VHADQSSCTFENLNPGLEYNVSVYTVKDD 1252
Cdd:smart00060    2 SPPSNLRVTDVTSTSV-TLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVnVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 564368920   1253 KES 1255
Cdd:smart00060   81 GEG 83
fn1 pfam00039
Fibronectin type I domain;
2174-2209 6.72e-08

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 50.39  E-value: 6.72e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564368920  2174 CYDD--GKTYHVGEQWQKEYL-GAICSCTCFGGQRG-WRC 2209
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 140-182 9.63e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 50.02  E-value: 9.63e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 564368920  140 NRCHEG--GQSYKIGDKWRRPHEtgGYMLECLCLGNgKGEWTCKP 182
Cdd:cd00061     1 EKCFDPqtGVFYRVGETWERPSE--GHVLQCTCLGN-RGEARCDP 42
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
1730-1972 1.40e-07

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 57.26  E-value: 1.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1730 TQVSPTTLTAQWTAPSVKLTGYRVRVTPKEKTGPM---KEINLSPDSTSVIVsglmvATKYEVSVYALKDT--LTSRPAQ 1804
Cdd:COG4733   456 QSVAGRTLTVSTAYSETPEAGAVWAFGPDELETQLfrvVSIEENEDGTYTIT-----AVQHAPEKYAAIDAgaFDDVPPQ 530

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1805 GVVTTLEnVSPPRRARVTDATETTITISWRTKTETITgFQVDAIPANGQ-TPVQRTISPdvrSYTITGLQPGtDYKIHLY 1883
Cdd:COG4733   531 WPPVNVT-TSESLSVVAQGTAVTTLTVSWDAPAGAVA-YEVEWRRDDGNwVSVPRTSGT---SFEVPGIYAG-DYEVRVR 604

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1884 TLNDNARSSPVVIDASTAI----DAPSNLRFLTTTPNSLLV--SW-QAPRARITGYIIKYEKPGSPPREVVPRPRPGVTE 1956
Cdd:COG4733   605 AINALGVSSAWAASSETTVtgktAPPPAPTGLTATGGLGGItlSWsFPVDADTLRTEIRYSTTGDWASATVAQALYPGNT 684

                         250
                  ....*....|....*.
gi 564368920 1957 ATITGLEPGTEYTIYV 1972
Cdd:COG4733   685 YTLAGLKAGQTYYYRA 700
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1814-1888 1.89e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 1.89e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920   1814 SPPRRARVTDATETTITISWRTKTET-----ITGFQVDAIPANGQTpVQRTISPDVRSYTITGLQPGTDYKIHLYTLNDN 1888
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEW-KEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
fn1 pfam00039
Fibronectin type I domain;
53-88 2.27e-07

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 48.85  E-value: 2.27e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564368920    53 CFDN--GKHYQINQQWERTYL-GNALVCTCYGGSRG-FNC 88
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 907-985 4.10e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 4.10e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920    907 PAPKDLQFVEVTDVKVTIMWTPPNSAV-TGYRVDVLPVNLPGEHGQR--LPVNRNTFAEVTGLSPGVTYLFKVFAVHQGR 983
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGiTGYIVGYRVEYREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 564368920    984 ES 985
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 726-808 5.73e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 5.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  726 SVTEITASSFVVSWVSASDT---VSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEEGKQSLIL 802
Cdd:cd00063     8 RVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                  ....*.
gi 564368920  803 STSQTT 808
Cdd:cd00063    88 SVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
1091-1158 6.52e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 6.52e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564368920  1091 PPYN---TEVTETTIVITWTPAPR-----IGFKLGVRPSQGGEAPREVT--SDSGSIVVSGLTPGVEYTYTIQVLRDG 1158
Cdd:pfam00041    2 APSNltvTDVTSTSLTVSWTPPPDgngpiTGYEVEYRPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1999-2057 6.65e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 6.65e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564368920  1999 TISWT-PFQESSE---YIISCQPVGTDEEPLQFQVPGTSTSATLTGLTRGVTYNIIVEALHNQ 2057
Cdd:pfam00041   17 TVSWTpPPDGNGPitgYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1634-1710 4.33e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 4.33e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920   1634 PKGLAFTDVDVDSIKIAWESPQ-----GQVSRYRVTYSSPEDGIHELfpAPDGDEDTAELHGLRPGSEYTVSVVALHGGM 1708
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEV--NVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 564368920   1709 ES 1710
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 726-790 7.34e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.07  E-value: 7.34e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564368920    726 SVTEITASSFVVSW-VSASDTVSGFRVEYELSEEGDEPQYLDLPSTA--TSVNIPDLLPGRKYIVNVY 790
Cdd:smart00060    8 RVTDVTSTSVTLSWePPPDDGITGYIVGYRVEYREEGSEWKEVNVTPssTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 616-688 8.83e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 8.83e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564368920    616 ITETPSQPNSHPIQWNAPEPSHITKYILRWRP--KTSTGRWKEATIPGHLNSYTIKGLTPGVIYEGQLISIQQYG 688
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVeyREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1095-1160 2.35e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.53  E-value: 2.35e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564368920   1095 TEVTETTIVITWTP-------APRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYTYTIQVLRDGQE 1160
Cdd:smart00060   10 TDVTSTSVTLSWEPppddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 611-678 8.40e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.25  E-value: 8.40e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  611 PVQVIITETpsQPNSHPIQWNAPEP--SHITKYILRWRPKTSTGRWKEATIPGHLNSYTIKGLTPGVIYE 678
Cdd:cd00063     4 PTNLRVTDV--TSTSVTLSWTPPEDdgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYE 71
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 308-347 1.42e-04

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 41.18  E-value: 1.42e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 564368920    308 CVTD-SGVVYSVGMQWLK-SQGDKQMLCTCLGNG---VSCQETAV 347
Cdd:smart00058    1 CFDEeTGTTYRVGDTWERpYEGGHVLQCTCLGGGrgeWKCDPVPV 45
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
1374-1904 1.50e-04

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 47.25  E-value: 1.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1374 TVHWVAP---RAPITGYIIRHHAEHSAGRPRQDRV-PPSRNSITL---TNLNPGTEYI-----------VTIIAVNGREe 1435
Cdd:COG4733   384 TVTFSVGldgLVATPGDVIAVADDVLAGRRIGGRVsSVDGRVVTLdrpVTMEAGDRYLrvrlpdgtsvaRTVQSVAGRT- 462

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1436 spplIGQQSTVSDVPRDLEVIAStptslliswEPPAVSVRYYRITYGETGGNSpvqEFTVpgsksTATINNikPGADYTI 1515
Cdd:COG4733   463 ----LTVSTAYSETPEAGAVWAF---------GPDELETQLFRVVSIEENEDG---TYTI-----TAVQHA--PEKYAAI 519

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1516 TLYAVTGRGDSPAsskPVSINYQTEIDKPSQMQVTdvqdNSISVRWLPSTSpVTGYRVTTAPKNGlgptkSQTVSPDQTE 1595
Cdd:COG4733   520 DAGAFDDVPPQWP---PVNVTTSESLSVVAQGTAV----TTLTVSWDAPAG-AVAYEVEWRRDDG-----NWVSVPRTSG 586

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1596 MTIEGLQPTV-EYVVSVYAQNRNGESQPLVQTAVTNID-------RPKGLAFTdVDVDSIKIAWESPQG-QVSRYRVTYS 1666
Cdd:COG4733   587 TSFEVPGIYAgDYEVRVRAINALGVSSAWAASSETTVTgktapppAPTGLTAT-GGLGGITLSWSFPVDaDTLRTEIRYS 665

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1667 SPEDGIHELFPAPDGDEDTAELHGLRPGSEYTVSVVAL-HGGMESQPLIGVQSTAIPAPTNLKFTQVSPTTLTAQ---WT 1742
Cdd:COG4733   666 TTGDWASATVAQALYPGNTYTLAGLKAGQTYYYRARAVdRSGNVSAWWVSGQASADAAGILDAITGQILETELGQeldAI 745

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1743 APSVKLTGYRVRVTPKEKTGPMKEINLSPDSTSVIVSGLMVATKYEVSVY-ALKDTLTSRPAQGVVTTLENVSPPRRARV 1821
Cdd:COG4733   746 IQNATVAEVVAATVTDVTAQIDTAVLFAGVATAAAIGAEARVAATVAESAtAAAATGTAADAAGDASGGVTAGTSGTTGA 825

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1822 TDATETTITISWRTKTETITG---FQVDAIPANGQTPVQRTISPDVRSYTiTGLQPGTDYKIHLYTLNDNARSSPVVIDA 1898
Cdd:COG4733   826 GDTAASTTRVAAAVVLAGVVVygdAIIESGNTGDIVATGDIASAAAGAVA-TTVSGTTAADVSAVADSTAASLTAIVIAA 904


                  ....*.
gi 564368920 1899 STAIDA 1904
Cdd:COG4733   905 TTIIDA 910
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 307-345 2.05e-04

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 40.78  E-value: 2.05e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 564368920  307 HCVTDS-GVVYSVGMQWLKSQGDKQMLCTCLGN--GVSCQET 345
Cdd:cd00061     2 KCFDPQtGVFYRVGETWERPSEGHVLQCTCLGNrgEARCDPV 43
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
723-1224 2.27e-04

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 46.48  E-value: 2.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  723 TSESVTEITASSFVVSWVSASDTVSGFRVEyelSEEGDE----PQYLDLPSTATSVNI-PDLLPGRKYIV--------NV 789
Cdd:COG4733   427 TLDRPVTMEAGDRYLRVRLPDGTSVARTVQ---SVAGRTltvsTAYSETPEAGAVWAFgPDELETQLFRVvsieenedGT 503

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  790 YQIS----EEGKQSLILSTSQTTAPDAPPDPTV----------DQVDDTSIVVRWSRPQAPITgYRIVYSPsveGSSTEL 855
Cdd:COG4733   504 YTITavqhAPEKYAAIDAGAFDDVPPQWPPVNVttseslsvvaQGTAVTTLTVSWDAPAGAVA-YEVEWRR---DDGNWV 579

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  856 NLPET-ANSVTLSDLQPGvQYNITIYAVEENQESTPVFIQQETTGVPRSDDVPAPKDLQfVEVTDVKVTIMWT-PPNSAV 933
Cdd:COG4733   580 SVPRTsGTSFEVPGIYAG-DYEVRVRAINALGVSSAWAASSETTVTGKTAPPPAPTGLT-ATGGLGGITLSWSfPVDADT 657

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920  934 TGYRVDVLPVNLPGEHGQRLPVNRNTFAEVTGLSPGVTYLFKVFAV-HQGRESkPLTAQQTTKLDAPTNLQFVN----ET 1008
Cdd:COG4733   658 LRTEIRYSTTGDWASATVAQALYPGNTYTLAGLKAGQTYYYRARAVdRSGNVS-AWWVSGQASADAAGILDAITgqilET 736

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1009 DRTVLVTWTPPRARIAGY-RLTVGLTRGGQPKQYNVGPMASkyplrNLQPGSEYTVTLMAVkGNQQSPKATGVFTTLQPL 1087
Cdd:COG4733   737 ELGQELDAIIQNATVAEVvAATVTDVTAQIDTAVLFAGVAT-----AAAIGAEARVAATVA-ESATAAAATGTAADAAGD 810

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1088 RSIppYNTEVTETTIVITWTPAPRIgfklgvrpsqggeapREVTSDSGSIVVSGLTPGVEYTYTIQVLRDGQERDAPIVN 1167
Cdd:COG4733   811 ASG--GVTAGTSGTTGAGDTAASTT---------------RVAAAVVLAGVVVYGDAIIESGNTGDIVATGDIASAAAGA 873

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 564368920 1168 RVVTplspPTNLHLEANPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGTALEEVV 1224
Cdd:COG4733   874 VATT----VSGTTAADVSAVADSTAASLTAIVIAATTIIDAIGDGTTREPAGDIGAS 926
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1095-1160 2.53e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 2.53e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564368920 1095 TEVTETTIVITWTP-----APRIGFKLGVRPSQGGEaPREVTSDSG---SIVVSGLTPGVEYTYTIQVLRDGQE 1160
Cdd:cd00063    10 TDVTSTSVTLSWTPpeddgGPITGYVVEYREKGSGD-WKEVEVTPGsetSYTLTGLKPGTEYEFRVRAVNGGGE 82
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
1820-2047 2.93e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 43.01  E-value: 2.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1820 RVTDATETTITISWRTKTETITGFQVDAIP--------ANGQTPVQRTI----SPDVRS--YTITGLQPGTD--YKIHL- 1882
Cdd:COG4733   430 RPVTMEAGDRYLRVRLPDGTSVARTVQSVAgrtltvstAYSETPEAGAVwafgPDELETqlFRVVSIEENEDgtYTITAv 509

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1883 ------YTLNDNA-------RSSPVVIDASTAIDAPSNlrflTTTPNSLLVSWQAPRARITgYIIKYEKPGSpprEVVPR 1949
Cdd:COG4733   510 qhapekYAAIDAGafddvppQWPPVNVTTSESLSVVAQ----GTAVTTLTVSWDAPAGAVA-YEVEWRRDDG---NWVSV 581

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1950 PRPGVTEATITGLEPGTeYTIYVIAL-KNNQKSEPLIGRKK--TGQEA-------------LSQTTISWTPFQES--SEY 2011
Cdd:COG4733   582 PRTSGTSFEVPGIYAGD-YEVRVRAInALGVSSAWAASSETtvTGKTApppaptgltatggLGGITLSWSFPVDAdtLRT 660

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 564368920 2012 IISCQPVGTDEEPLQFQVPGTSTSATLTGLTRGVTY 2047
Cdd:COG4733   661 EIRYSTTGDWASATVAQALYPGNTYTLAGLKAGQTY 696
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
1097-1249 7.48e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 41.47  E-value: 7.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1097 VTETTIVITWTPAP-RIGFKLGVRPSqGGEAPREVTSDSGSIVVSGLTPGvEYTYTIQ-VLRDGQERDAPIVNRV----- 1169
Cdd:COG4733   549 TAVTTLTVSWDAPAgAVAYEVEWRRD-DGNWVSVPRTSGTSFEVPGIYAG-DYEVRVRaINALGVSSAWAASSETtvtgk 626

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368920 1170 VTPLSPPTNLhlEANPDTGVLTVSWERSTTPDITGYRITTTPTNGqQGTALEEVVHADQSSCTFENLNPGLEYNVSVYTV 1249
Cdd:COG4733   627 TAPPPAPTGL--TATGGLGGITLSWSFPVDADTLRTEIRYSTTGD-WASATVAQALYPGNTYTLAGLKAGQTYYYRARAV 703
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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