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Conserved domains on  [gi|564389402|ref|XP_006253289|]
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malignant fibrous histiocytoma-amplified sequence 1 isoform X2 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
109-371 5.08e-42

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 159.33  E-value: 5.08e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  109 LTELDVSHNRLtilgaevVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSFSCLNHLRTLDVDHNQ 188
Cdd:COG4886    98 LTELDLSGNEE-------LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQ 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  189 LTafpqqllqlaaleeldvssnrlrGLPEDISALRALKILWLSGAELGTLPSGFCELASLESLMLDNNGLQALPDEFSRL 268
Cdd:COG4886   171 LT-----------------------DLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANL 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  269 QRLKMLNLSSNLFEEFPaALLPLAGLEELYLSRNQLTSVPSLiAGLGRLLTLWLDNNRIrylpdSIVELTGLEELVLQGN 348
Cdd:COG4886   228 TNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQL-----TDLKLKELELLLGLNS 300

                         250       260
                  ....*....|....*....|...
gi 564389402  349 QIAVLPDNFGQLSRVGLWKIKDN 371
Cdd:COG4886   301 LLLLLLLLNLLELLILLLLLTTL 323
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 405-548 7.50e-15

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member cd09914:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 161  Bit Score: 73.14  E-value: 7.50e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  405 RLKLLLMGHKAAGKTLLRHCLTEDKVEGGQGGgdkeksylpfpplgSKGIEVTSWT--ADASRGLRFIVYDLAGDESYEV 482
Cdd:cd09914     1 EAKLMLVGQGGVGKTSLCKQLIGEKFDGDESS--------------THGINVQDWKipAPERKKIRLNVWDFGGQEIYHA 66

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564389402  483 IQPFFLSPGALYVLVVNLATYEprcFPTTVGSFLHRVGARVPHAVVCIVGTHADLCGERELEEKCL 548
Cdd:cd09914    67 THQFFLTSRSLYLLVFDLRTGD---EVSRVPYWLRQIKAFGGVSPVILVGTHIDESCDEDILKKAL 129
COR super family cl24610
C-terminal of Roc, COR, domain; The C-terminal of Roc domain, COR, along with Roc functions as ...
 656-902 6.07e-05

C-terminal of Roc, COR, domain; The C-terminal of Roc domain, COR, along with Roc functions as the putative regulator of kinase activity. It functions as a proper GTP-binding protein with a low GTPase activity somehow stimulating the kinase activity.


The actual alignment was detected with superfamily member pfam16095:

Pssm-ID: 406489  Cd Length: 196  Bit Score: 44.93  E-value: 6.07e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   656 PRSWQVLEElHFQPPQAQRLWLSWWDSARLGLQAGLT-EDRLQSALSYLHESGKLLYFEDSPALKEHVFHNLTRLID--- 731
Cdd:pfam16095    1 PKSWLAVRE-ALEKERQKKPYISYEEYRKICAENGIDdEEDQDTLLEFLHDLGVLLYFQDDPGLRDIVILNPQWLTNavy 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   732 -ILNVFFQRdaslllhklllgtNGEGEGEGESFPTIAvptpgQDPLRATQLHHyvegfllhgllpaHIIRLLlkphvqaq 810
Cdd:pfam16095   80 rVLDSKHVL-------------NNNGILTHEDLEQIW-----KDPGYPRELHP-------------YLLRLM-------- 120

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   811 qdlqlllellEKMGLCYCLNKPKgkplNGSaawYKFPCYVQNEVPHAEAWINGTNlagqsfvaeqLQIEYSFPFtFPPGL 890
Cdd:pfam16095  121 ----------EKFELCYELPGDE----EGT---YLVPQLLPENPPELYDWDEENN----------LELRYQYDF-LPKGI 172

                          250
                   ....*....|..
gi 564389402   891 FARYSVQINSHV 902
Cdd:pfam16095  173 FSRLIVRLHKFI 184
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
109-371 5.08e-42

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 159.33  E-value: 5.08e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  109 LTELDVSHNRLtilgaevVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSFSCLNHLRTLDVDHNQ 188
Cdd:COG4886    98 LTELDLSGNEE-------LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQ 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  189 LTafpqqllqlaaleeldvssnrlrGLPEDISALRALKILWLSGAELGTLPSGFCELASLESLMLDNNGLQALPDEFSRL 268
Cdd:COG4886   171 LT-----------------------DLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANL 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  269 QRLKMLNLSSNLFEEFPaALLPLAGLEELYLSRNQLTSVPSLiAGLGRLLTLWLDNNRIrylpdSIVELTGLEELVLQGN 348
Cdd:COG4886   228 TNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQL-----TDLKLKELELLLGLNS 300

                         250       260
                  ....*....|....*....|...
gi 564389402  349 QIAVLPDNFGQLSRVGLWKIKDN 371
Cdd:COG4886   301 LLLLLLLLNLLELLILLLLLTTL 323
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 54-360 2.17e-19

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 94.14  E-value: 2.17e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   54 LPANIGDIEVLN----LGNNGLEDVPEGLGSaLGSLRVLVLRRNRFA-RLPPAVAELgHHLTELDVSHNRLTILGAEVVS 128
Cdd:PLN00113  228 IPYEIGGLTSLNhldlVYNNLTGPIPSSLGN-LKNLQYLFLYQNKLSgPIPPSIFSL-QKLISLDLSDNSLSGEIPELVI 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  129 ALRELRKLNLSHNQLPA-LPAQLGALAHLEELDVSFNRLA-HLPDSFSCLNHLRTLDVDHNQLTA-FPQQLLQLAALEEL 205
Cdd:PLN00113  306 QLQNLEILHLFSNNFTGkIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGeIPEGLCSSGNLFKL 385

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  206 DVSSNRLRG-LPEDISALRALKILWLSGAEL-GTLPSGFCELASLESLMLDNNGLQA----------------------- 260
Cdd:PLN00113  386 ILFSNSLEGeIPKSLGACRSLRRVRLQDNSFsGELPSEFTKLPLVYFLDISNNNLQGrinsrkwdmpslqmlslarnkff 465

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  261 --LPDeFSRLQRLKMLNLSSNLFEE-FPAALLPLAGLEELYLSRNQLTSV-PSLIAGLGRLLTLWLDNNRIR-YLPDSIV 335
Cdd:PLN00113  466 ggLPD-SFGSKRLENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKLSGEiPDELSSCKKLVSLDLSHNQLSgQIPASFS 544

                         330       340
                  ....*....|....*....|....*.
gi 564389402  336 ELTGLEELVLQGNQIA-VLPDNFGQL 360
Cdd:PLN00113  545 EMPVLSQLDLSQNQLSgEIPKNLGNV 570
RocCOR cd09914
Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family; RocCOR (or Roco) protein ...
 405-548 7.50e-15

Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family; RocCOR (or Roco) protein family is characterized by a superdomain containing a Ras-like GTPase domain, called Roc (Ras of complex proteins), and a characteristic second domain called COR (C-terminal of Roc). A kinase domain and diverse regulatory domains are also often found in Roco proteins. Their functions are diverse; in Dictyostelium discoideum, which encodes 11 Roco proteins, they are involved in cell division, chemotaxis and development, while in human, where 4 Roco proteins (LRRK1, LRRK2, DAPK1, and MFHAS1) are encoded, these proteins are involved in epilepsy and cancer. Mutations in LRRK2 (leucine-rich repeat kinase 2) are known to cause familial Parkinson's disease.


Pssm-ID: 206741 [Multi-domain]  Cd Length: 161  Bit Score: 73.14  E-value: 7.50e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  405 RLKLLLMGHKAAGKTLLRHCLTEDKVEGGQGGgdkeksylpfpplgSKGIEVTSWT--ADASRGLRFIVYDLAGDESYEV 482
Cdd:cd09914     1 EAKLMLVGQGGVGKTSLCKQLIGEKFDGDESS--------------THGINVQDWKipAPERKKIRLNVWDFGGQEIYHA 66

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564389402  483 IQPFFLSPGALYVLVVNLATYEprcFPTTVGSFLHRVGARVPHAVVCIVGTHADLCGERELEEKCL 548
Cdd:cd09914    67 THQFFLTSRSLYLLVFDLRTGD---EVSRVPYWLRQIKAFGGVSPVILVGTHIDESCDEDILKKAL 129
LRR_8 pfam13855
Leucine rich repeat;
247-304 1.51e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.53  E-value: 1.51e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   247 SLESLMLDNNGLQALPDE-FSRLQRLKMLNLSSNLFEEF-PAALLPLAGLEELYLSRNQL 304
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 76-193 3.58e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.96  E-value: 3.58e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   76 EGLGSaLGSLRVLVLRRNRFARlppaVAELG--HHLTELDVSHNRLT-----ILGAEVVSALRE-LRKLNLSHNQLPALp 147
Cdd:cd21340    62 ENLEN-LVNLKKLYLGGNRISV----VEGLEnlTNLEELHIENQRLPpgeklTFDPRSLAALSNsLRVLNISGNNIDSL- 135

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 564389402  148 AQLGALAHLEELDVSFNRLAHLPD---SFSCLNHLRTLDVDHNQLTAFP 193
Cdd:cd21340   136 EPLAPLRNLEQLDASNNQISDLEElldLLSSWPSLRELDLTGNPVCKKP 184
Roc pfam08477
Ras of Complex, Roc, domain of DAPkinase; Roc, or Ras of Complex, proteins are mitochondrial ...
 407-536 1.95e-08

Ras of Complex, Roc, domain of DAPkinase; Roc, or Ras of Complex, proteins are mitochondrial Rho proteins (Miro-1, and Miro-2) and atypical Rho GTPases. Full-length proteins have a unique domain organization, with tandem GTP-binding domains and two EF hand domains (pfam00036) that may bind calcium. They are also larger than classical small GTPases. It has been proposed that they are involved in mitochondrial homeostasis and apoptosis.


Pssm-ID: 462490 [Multi-domain]  Cd Length: 114  Bit Score: 53.28  E-value: 1.95e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   407 KLLLMGHKAAGKT--LLRHCltedkveggqgGGDKEKSYLPfpplgSKGIEVTSWTA----DASRGLRFIVYDLAGDESY 480
Cdd:pfam08477    1 KVVLLGDSGVGKTslLKRFV-----------DDTFDPKYKS-----TIGVDFKTKTVlendDNGKKIKLNIWDTAGQERF 64

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 564389402   481 EVIQPFFLSPGALYVLVVNLATYEprcfptTVGSFLHRVGARVPHAVVCIVGTHAD 536
Cdd:pfam08477   65 RSLHPFYYRGAAAALLVYDSRTFS------NLKYWLRELKKYAGNSPVILVGNKID 114
COR pfam16095
C-terminal of Roc, COR, domain; The C-terminal of Roc domain, COR, along with Roc functions as ...
 656-902 6.07e-05

C-terminal of Roc, COR, domain; The C-terminal of Roc domain, COR, along with Roc functions as the putative regulator of kinase activity. It functions as a proper GTP-binding protein with a low GTPase activity somehow stimulating the kinase activity.


Pssm-ID: 406489  Cd Length: 196  Bit Score: 44.93  E-value: 6.07e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   656 PRSWQVLEElHFQPPQAQRLWLSWWDSARLGLQAGLT-EDRLQSALSYLHESGKLLYFEDSPALKEHVFHNLTRLID--- 731
Cdd:pfam16095    1 PKSWLAVRE-ALEKERQKKPYISYEEYRKICAENGIDdEEDQDTLLEFLHDLGVLLYFQDDPGLRDIVILNPQWLTNavy 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   732 -ILNVFFQRdaslllhklllgtNGEGEGEGESFPTIAvptpgQDPLRATQLHHyvegfllhgllpaHIIRLLlkphvqaq 810
Cdd:pfam16095   80 rVLDSKHVL-------------NNNGILTHEDLEQIW-----KDPGYPRELHP-------------YLLRLM-------- 120

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   811 qdlqlllellEKMGLCYCLNKPKgkplNGSaawYKFPCYVQNEVPHAEAWINGTNlagqsfvaeqLQIEYSFPFtFPPGL 890
Cdd:pfam16095  121 ----------EKFELCYELPGDE----EGT---YLVPQLLPENPPELYDWDEENN----------LELRYQYDF-LPKGI 172

                          250
                   ....*....|..
gi 564389402   891 FARYSVQINSHV 902
Cdd:pfam16095  173 FSRLIVRLHKFI 184
PTZ00132 PTZ00132
GTP-binding nuclear protein Ran; Provisional
 398-480 1.55e-03

GTP-binding nuclear protein Ran; Provisional


Pssm-ID: 240284 [Multi-domain]  Cd Length: 215  Bit Score: 41.22  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  398 SQPAVQPRLKLLLMGHKAAGKTLL--RHcLTedkveggqggGDKEKSYLPfpplgSKGIEVTSWTADASRG-LRFIVYDL 474
Cdd:PTZ00132    2 QQMDEVPEFKLILVGDGGVGKTTFvkRH-LT----------GEFEKKYIP-----TLGVEVHPLKFYTNCGpICFNVWDT 65


                  ....*.
gi 564389402  475 AGDESY 480
Cdd:PTZ00132   66 AGQEKF 71
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
109-371 5.08e-42

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 159.33  E-value: 5.08e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  109 LTELDVSHNRLtilgaevVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSFSCLNHLRTLDVDHNQ 188
Cdd:COG4886    98 LTELDLSGNEE-------LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQ 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  189 LTafpqqllqlaaleeldvssnrlrGLPEDISALRALKILWLSGAELGTLPSGFCELASLESLMLDNNGLQALPDEFSRL 268
Cdd:COG4886   171 LT-----------------------DLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANL 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  269 QRLKMLNLSSNLFEEFPaALLPLAGLEELYLSRNQLTSVPSLiAGLGRLLTLWLDNNRIrylpdSIVELTGLEELVLQGN 348
Cdd:COG4886   228 TNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQL-----TDLKLKELELLLGLNS 300

                         250       260
                  ....*....|....*....|...
gi 564389402  349 QIAVLPDNFGQLSRVGLWKIKDN 371
Cdd:COG4886   301 LLLLLLLLNLLELLILLLLLTTL 323
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
42-373 1.51e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 143.54  E-value: 1.51e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   42 DSLESPDAPQLVLPANIGDIEVLNLGNNGLEDVPEGLGSALGSLRVLVLRRNRfarlppAVAELgHHLTELDVSHNRLTI 121
Cdd:COG4886    55 LLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNL-TNLESLDLSGNQLTD 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  122 LGAEVvSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSFSCLNHLRTLDVDHNQLTAFPQQLLQLAA 201
Cdd:COG4886   128 LPEEL-ANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTN 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  202 LEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPSgFCELASLESLMLDNNGLQALPDEfSRLQRLKMLNLSSNLF 281
Cdd:COG4886   207 LEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQL 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  282 EEFpaALLPLAGLEELYLSRNQLTSVPSLIAGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDNFGQLS 361
Cdd:COG4886   285 TDL--KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLL 362

                         330
                  ....*....|..
gi 564389402  362 RVGLWKIKDNPL 373
Cdd:COG4886   363 LTLLLTLGLLGL 374
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-363 9.35e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 140.84  E-value: 9.35e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   56 ANIGDIEVLNLGNNGLEDVPEGLGSaLGSLRVLVLRRNRFARLPPAVAELgHHLTELDVSHNRLTILGAEVvSALRELRK 135
Cdd:COG4886   110 SNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLPEPLGNL-TNLKSLDLSNNQLTDLPEEL-GNLTNLKE 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  136 LNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSFSCLNHLRTLDVDHNQLTAFPqqllqlaaleeldvssnrlrgl 215
Cdd:COG4886   187 LDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP---------------------- 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  216 peDISALRALKILWLSGAELGTLPSgFCELASLESLMLDNNGLQALP----DEFSRLQRLKMLNLSSNLFEEFPAALLPL 291
Cdd:COG4886   245 --ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDLKlkelELLLGLNSLLLLLLLLNLLELLILLLLLT 321

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564389402  292 AGLEELYLSRNQLTSVPSLIAGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDNFGQLSRV 363
Cdd:COG4886   322 TLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLL 393
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
27-356 1.31e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 125.82  E-value: 1.31e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   27 SNLRQLTLScpgagGDSLESpdapqlvLPANIGD---IEVLNLGNNGLEDVPEGLGSaLGSLRVLVLRRNRFARLPPAVA 103
Cdd:COG4886   113 TNLESLDLS-----GNQLTD-------LPEELANltnLKELDLSNNQLTDLPEPLGN-LTNLKSLDLSNNQLTDLPEELG 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  104 ELgHHLTELDVSHNRLTILGAEvVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPdSFSCLNHLRTLD 183
Cdd:COG4886   180 NL-TNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELD 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  184 VDHNQLTAFPqqllqlaaleeldvssnrlrglpeDISALRALKILWLSGAELGTLPSGFCELASLESLMLDNNGLQALPD 263
Cdd:COG4886   257 LSNNQLTDLP------------------------PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLE 312

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  264 EFSRLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLIAGLGRLLTLWLDNNRIRYLPDSIVELTGLEEL 343
Cdd:COG4886   313 LLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLL 392

                         330
                  ....*....|...
gi 564389402  344 VLQGNQIAVLPDN 356
Cdd:COG4886   393 LLTTTAGVLLLTL 405
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 54-360 2.17e-19

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 94.14  E-value: 2.17e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   54 LPANIGDIEVLN----LGNNGLEDVPEGLGSaLGSLRVLVLRRNRFA-RLPPAVAELgHHLTELDVSHNRLTILGAEVVS 128
Cdd:PLN00113  228 IPYEIGGLTSLNhldlVYNNLTGPIPSSLGN-LKNLQYLFLYQNKLSgPIPPSIFSL-QKLISLDLSDNSLSGEIPELVI 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  129 ALRELRKLNLSHNQLPA-LPAQLGALAHLEELDVSFNRLA-HLPDSFSCLNHLRTLDVDHNQLTA-FPQQLLQLAALEEL 205
Cdd:PLN00113  306 QLQNLEILHLFSNNFTGkIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGeIPEGLCSSGNLFKL 385

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  206 DVSSNRLRG-LPEDISALRALKILWLSGAEL-GTLPSGFCELASLESLMLDNNGLQA----------------------- 260
Cdd:PLN00113  386 ILFSNSLEGeIPKSLGACRSLRRVRLQDNSFsGELPSEFTKLPLVYFLDISNNNLQGrinsrkwdmpslqmlslarnkff 465

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  261 --LPDeFSRLQRLKMLNLSSNLFEE-FPAALLPLAGLEELYLSRNQLTSV-PSLIAGLGRLLTLWLDNNRIR-YLPDSIV 335
Cdd:PLN00113  466 ggLPD-SFGSKRLENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKLSGEiPDELSSCKKLVSLDLSHNQLSgQIPASFS 544

                         330       340
                  ....*....|....*....|....*.
gi 564389402  336 ELTGLEELVLQGNQIA-VLPDNFGQL 360
Cdd:PLN00113  545 EMPVLSQLDLSQNQLSgEIPKNLGNV 570
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
88-339 1.97e-17

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 87.44  E-value: 1.97e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   88 LVLRRNRFARLPPAVAElghHLTELDVSHNRLTILGAEVVSALRELrklNLSHNQLPALPAQLGALahLEELDVSFNRLA 167
Cdd:PRK15370  183 LRLKILGLTTIPACIPE---QITTLILDNNELKSLPENLQGNIKTL---YANSNQLTSIPATLPDT--IQEMELSINRIT 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  168 HLPDSFSclNHLRTLDVDHNQLTAFPqqLLQLAALEELDVSSNRLRGLPEDI-SALRALKILWLSGAEL-GTLPSGfcel 245
Cdd:PRK15370  255 ELPERLP--SALQSLDLFHNKISCLP--ENLPEELRYLSVYDNSIRTLPAHLpSGITHLNVQSNSLTALpETLPPG---- 326

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  246 asLESLMLDNNGLQALPDefSRLQRLKMLNLSSNLFEEFPAALLPLagLEELYLSRNQLTSVP-SLIAGLGRLLTLWldN 324
Cdd:PRK15370  327 --LKTLEAGENALTSLPA--SLPPELQVLDVSKNQITVLPETLPPT--ITTLDVSRNALTNLPeNLPAALQIMQASR--N 398

                         250
                  ....*....|....*
gi 564389402  325 NRIRyLPDSIVELTG 339
Cdd:PRK15370  399 NLVR-LPESLPHFRG 412
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
63-373 6.86e-17

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 85.98  E-value: 6.86e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   63 VLNLGNNGLEDVPEGLgsalgslrvlvlrrnrfarlpPAvaelghHLTELDVSHNRLTILGAevvsALRELRKLNLSHNQ 142
Cdd:PRK15387  205 VLNVGESGLTTLPDCL---------------------PA------HITTLVIPDNNLTSLPA----LPPELRTLEVSGNQ 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  143 LPALPAQLGALAhleELDVSFNRLAHLPDSFSCLNHLRTLDvdhNQLTAFPQQLLQLAALeelDVSSNRLRGLPEDISAL 222
Cdd:PRK15387  254 LTSLPVLPPGLL---ELSIFSNPLTHLPALPSGLCKLWIFG---NQLTSLPVLPPGLQEL---SVSDNQLASLPALPSEL 324

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  223 RALKILWLSGAELGTLPSGfcelasLESLMLDNNGLQALPDEFSRLQRLKMLNlssNLFEEFPAalLPlAGLEELYLSRN 302
Cdd:PRK15387  325 CKLWAYNNQLTSLPTLPSG------LQELSVSDNQLASLPTLPSELYKLWAYN---NRLTSLPA--LP-SGLKELIVSGN 392

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564389402  303 QLTSVPSLIAGLGRLLtlwLDNNRIRYLPdsiVELTGLEELVLQGNQIAVLPDNFGQLSRVGLWKIKDNPL 373
Cdd:PRK15387  393 RLTSLPVLPSELKELM---VSGNRLTSLP---MLPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPL 457
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
54-239 2.68e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 83.98  E-value: 2.68e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   54 LPANIGD-IEVLNLGNNGLEDVPEGLGSALGSlrvLVLRRNRFARLPPAVAElghHLTELDVSHNRLTILGAEVVSALRE 132
Cdd:PRK15370  235 IPATLPDtIQEMELSINRITELPERLPSALQS---LDLFHNKISCLPENLPE---ELRYLSVYDNSIRTLPAHLPSGITH 308

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  133 lrkLNLSHNQLPALPAQLGalAHLEELDVSFNRLAHLPDSFSclNHLRTLDVDHNQLTAFPqqLLQLAALEELDVSSNRL 212
Cdd:PRK15370  309 ---LNVQSNSLTALPETLP--PGLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLP--ETLPPTITTLDVSRNAL 379

                         170       180
                  ....*....|....*....|....*..
gi 564389402  213 RGLPEDISAlrALKILWLSGAELGTLP 239
Cdd:PRK15370  380 TNLPENLPA--ALQIMQASRNNLVRLP 404
RocCOR cd09914
Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family; RocCOR (or Roco) protein ...
 405-548 7.50e-15

Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family; RocCOR (or Roco) protein family is characterized by a superdomain containing a Ras-like GTPase domain, called Roc (Ras of complex proteins), and a characteristic second domain called COR (C-terminal of Roc). A kinase domain and diverse regulatory domains are also often found in Roco proteins. Their functions are diverse; in Dictyostelium discoideum, which encodes 11 Roco proteins, they are involved in cell division, chemotaxis and development, while in human, where 4 Roco proteins (LRRK1, LRRK2, DAPK1, and MFHAS1) are encoded, these proteins are involved in epilepsy and cancer. Mutations in LRRK2 (leucine-rich repeat kinase 2) are known to cause familial Parkinson's disease.


Pssm-ID: 206741 [Multi-domain]  Cd Length: 161  Bit Score: 73.14  E-value: 7.50e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  405 RLKLLLMGHKAAGKTLLRHCLTEDKVEGGQGGgdkeksylpfpplgSKGIEVTSWT--ADASRGLRFIVYDLAGDESYEV 482
Cdd:cd09914     1 EAKLMLVGQGGVGKTSLCKQLIGEKFDGDESS--------------THGINVQDWKipAPERKKIRLNVWDFGGQEIYHA 66

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564389402  483 IQPFFLSPGALYVLVVNLATYEprcFPTTVGSFLHRVGARVPHAVVCIVGTHADLCGERELEEKCL 548
Cdd:cd09914    67 THQFFLTSRSLYLLVFDLRTGD---EVSRVPYWLRQIKAFGGVSPVILVGTHIDESCDEDILKKAL 129
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 108-359 3.23e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.03  E-value: 3.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  108 HLTELDVSHNRLTI-LGAEVVSALRELRKLNLSHNQLPAlPAQLGALAHLEELDVSFNRLA-HLPDSFSCLNHLRTLDVD 185
Cdd:PLN00113   94 YIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTG-SIPRGSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLG 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  186 HNQLTA-FPQQLLQLAALEELDVSSNRLRG-LPEDISALRALKILWLSGAEL-GTLPSGFCELASLESLMLDNNGLQA-L 261
Cdd:PLN00113  173 GNVLVGkIPNSLTNLTSLEFLTLASNQLVGqIPRELGQMKSLKWIYLGYNNLsGEIPYEIGGLTSLNHLDLVYNNLTGpI 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  262 PDEFSRLQRLKMLNLSSNLFE-EFPAALLPLAGLEELYLSRNQLT-SVPSLIAGLGRLLTLWL-DNNRIRYLPDSIVELT 338
Cdd:PLN00113  253 PSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLfSNNFTGKIPVALTSLP 332

                         250       260
                  ....*....|....*....|..
gi 564389402  339 GLEELVLQGNQIA-VLPDNFGQ 359
Cdd:PLN00113  333 RLQVLQLWSNKFSgEIPKNLGK 354
LRR_8 pfam13855
Leucine rich repeat;
247-304 1.51e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.53  E-value: 1.51e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   247 SLESLMLDNNGLQALPDE-FSRLQRLKMLNLSSNLFEEF-PAALLPLAGLEELYLSRNQL 304
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 76-193 3.58e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.96  E-value: 3.58e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   76 EGLGSaLGSLRVLVLRRNRFARlppaVAELG--HHLTELDVSHNRLT-----ILGAEVVSALRE-LRKLNLSHNQLPALp 147
Cdd:cd21340    62 ENLEN-LVNLKKLYLGGNRISV----VEGLEnlTNLEELHIENQRLPpgeklTFDPRSLAALSNsLRVLNISGNNIDSL- 135

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 564389402  148 AQLGALAHLEELDVSFNRLAHLPD---SFSCLNHLRTLDVDHNQLTAFP 193
Cdd:cd21340   136 EPLAPLRNLEQLDASNNQISDLEElldLLSSWPSLRELDLTGNPVCKKP 184
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
15-283 5.81e-10

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 63.26  E-value: 5.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   15 WRDAA-LRARKLRSNLRQLTLSCPGAGGDSLESPDAPQLVLPANI-GDIEVLNLGNNGLEDVPeGLGSALGSLRVLVLRR 92
Cdd:PRK15387  176 WRRAApAEESRGRAAVVQKMRACLNNGNAVLNVGESGLTTLPDCLpAHITTLVIPDNNLTSLP-ALPPELRTLEVSGNQL 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   93 NRFARLPPAVAELG------HHLTELDVSHNRLTILGAEVVSAL---RELRKLNLSHNQL---PALPAQLGAL------- 153
Cdd:PRK15387  255 TSLPVLPPGLLELSifsnplTHLPALPSGLCKLWIFGNQLTSLPvlpPGLQELSVSDNQLaslPALPSELCKLwaynnql 334

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  154 -------AHLEELDVSFNRLAHLPdsfSCLNHLRTLDVDHNQLTAFPQQLLQLAALEeldVSSNRLRGLPEDISALRALK 226
Cdd:PRK15387  335 tslptlpSGLQELSVSDNQLASLP---TLPSELYKLWAYNNRLTSLPALPSGLKELI---VSGNRLTSLPVLPSELKELM 408

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 564389402  227 ILWLSGAELGTLPSGfcelasLESLMLDNNGLQALPDEFSRLQRLKMLNLSSNLFEE 283
Cdd:PRK15387  409 VSGNRLTSLPMLPSG------LLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSE 459
LRR_8 pfam13855
Leucine rich repeat;
84-143 1.81e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 1.81e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402    84 SLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTILGAEVVSALRELRKLNLSHNQL 143
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 84-192 2.38e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 2.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   84 SLRVLVLRRNRFARLPPavaeLGH--HLTELDVSHNRLTILgaEVVSALRELRKLNLSHNQ---------LPAL------ 146
Cdd:cd21340    25 NLKVLYLYDNKITKIEN----LEFltNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRisvveglenLTNLeelhie 98

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  147 -------------PAQLGALAH-LEELDVSFNRLAHLpDSFSCLNHLRTLDVDHNQLTAF 192
Cdd:cd21340    99 nqrlppgekltfdPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDL 157
LRR_8 pfam13855
Leucine rich repeat;
131-189 3.30e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 3.30e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564389402   131 RELRKLNLSHNQLPAL-PAQLGALAHLEELDVSFNRLAHL-PDSFSCLNHLRTLDVDHNQL 189
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
Roc pfam08477
Ras of Complex, Roc, domain of DAPkinase; Roc, or Ras of Complex, proteins are mitochondrial ...
 407-536 1.95e-08

Ras of Complex, Roc, domain of DAPkinase; Roc, or Ras of Complex, proteins are mitochondrial Rho proteins (Miro-1, and Miro-2) and atypical Rho GTPases. Full-length proteins have a unique domain organization, with tandem GTP-binding domains and two EF hand domains (pfam00036) that may bind calcium. They are also larger than classical small GTPases. It has been proposed that they are involved in mitochondrial homeostasis and apoptosis.


Pssm-ID: 462490 [Multi-domain]  Cd Length: 114  Bit Score: 53.28  E-value: 1.95e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   407 KLLLMGHKAAGKT--LLRHCltedkveggqgGGDKEKSYLPfpplgSKGIEVTSWTA----DASRGLRFIVYDLAGDESY 480
Cdd:pfam08477    1 KVVLLGDSGVGKTslLKRFV-----------DDTFDPKYKS-----TIGVDFKTKTVlendDNGKKIKLNIWDTAGQERF 64

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 564389402   481 EVIQPFFLSPGALYVLVVNLATYEprcfptTVGSFLHRVGARVPHAVVCIVGTHAD 536
Cdd:pfam08477   65 RSLHPFYYRGAAAALLVYDSRTFS------NLKYWLRELKKYAGNSPVILVGNKID 114
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
211-415 1.65e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 55.47  E-value: 1.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  211 RLRG-LPEDISALRaLKILWLSgaelgTLPSGFCElaSLESLMLDNNGLQALPDefsrlqrlkmlNLSSNLfeefpaall 289
Cdd:PRK15370  171 RMRDcLKNNKTELR-LKILGLT-----TIPACIPE--QITTLILDNNELKSLPE-----------NLQGNI--------- 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  290 plaglEELYLSRNQLTSVPSLIAGLGRLLTLwlDNNRIRYLPDSIVelTGLEELVLQGNQIAVLPDNFGQLSRVglWKIK 369
Cdd:PRK15370  223 -----KTLYANSNQLTSIPATLPDTIQEMEL--SINRITELPERLP--SALQSLDLFHNKISCLPENLPEELRY--LSVY 291

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 564389402  370 DNPLIQPPyEVCMKGIPYIAAYQKELAHSQPAVQPRLKLLLMGHKA 415
Cdd:PRK15370  292 DNSIRTLP-AHLPSGITHLNVQSNSLTALPETLPPGLKTLEAGENA 336
PLN03150 PLN03150
hypothetical protein; Provisional
 215-327 1.86e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 55.21  E-value: 1.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  215 LPEDISALRALKilwlsgAELGtLPSGF------------------CELAS------LESLMLDNNGLQA-LPDEFSRLQ 269
Cdd:PLN03150  370 LLEEVSALQTLK------SSLG-LPLRFgwngdpcvpqqhpwsgadCQFDStkgkwfIDGLGLDNQGLRGfIPNDISKLR 442

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  270 RLKMLNLSSNLFE-EFPAALLPLAGLEELYLSRNQLT-SVPSLIAGLGRLLTLWLDNNRI 327
Cdd:PLN03150  443 HLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 107-321 5.73e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.33  E-value: 5.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  107 HHLteldvSHNRLTILGAEVVSALRELRKLNLSHNQLPALPaQLGALAHLEELDVSFNRLAHLpDSFSCLNHLRTLDVDH 186
Cdd:cd21340     5 THL-----YLNDKNITKIDNLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  187 NQLTafpqqllqlaaleeldvssnRLRGLpEDISALRALKIlwlsgaELGTLPSGfcelaslESLMLDNNGLQALpdefs 266
Cdd:cd21340    78 NRIS--------------------VVEGL-ENLTNLEELHI------ENQRLPPG-------EKLTFDPRSLAAL----- 118

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 564389402  267 rLQRLKMLNLSSNLFEEfPAALLPLAGLEELYLSRNQLTSVPSLIAGLGRLLTLW 321
Cdd:cd21340   119 -SNSLRVLNISGNNIDS-LEPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLR 171
LRR_8 pfam13855
Leucine rich repeat;
293-350 1.01e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 1.01e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   293 GLEELYLSRNQLTSV-PSLIAGLGRLLTLWLDNNRIRYL-PDSIVELTGLEELVLQGNQI 350
Cdd:pfam13855    2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 61-189 1.08e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.93  E-value: 1.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   61 IEVLNLG-NNGLEDVPEGLGSAlgSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTILGAEVVSALRELRKLNLS 139
Cdd:PLN00113  454 LQMLSLArNKFFGGLPDSFGSK--RLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLS 531

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 564389402  140 HNQLPA-LPAQLGALAHLEELDVSFNRLA-HLPDSFSCLNHLRTLDVDHNQL 189
Cdd:PLN00113  532 HNQLSGqIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHL 583
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 217-377 2.48e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.40  E-value: 2.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  217 EDISALRALKILWLSGAELGTLPsGFCELASLESLMLDNNGLQALpDEFSRLQRLKMLNLSSNLFEEfpaallpLAGLE- 295
Cdd:cd21340    18 DNLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISV-------VEGLEn 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  296 -----ELYLSRNQL------TSVPSLIAGLGRLLTLwLD--NNRIRYLpDSIVELTGLEELVLQGNQIAVLPDNFGQLSR 362
Cdd:cd21340    89 ltnleELHIENQRLppgeklTFDPRSLAALSNSLRV-LNisGNNIDSL-EPLAPLRNLEQLDASNNQISDLEELLDLLSS 166

                         170
                  ....*....|....*...
gi 564389402  363 VG-LWKI--KDNPLIQPP 377
Cdd:cd21340   167 WPsLRELdlTGNPVCKKP 184
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 230-360 3.40e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.39  E-value: 3.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  230 LSGAEL-GTLPSGFCELASLESLMLDNNGLQA-LPDE-FSRLQRLKMLNLSSNLFE-EFPAALLPlaGLEELYLSRNQLT 305
Cdd:PLN00113   76 LSGKNIsGKISSAIFRLPYIQTINLSNNQLSGpIPDDiFTTSSSLRYLNLSNNNFTgSIPRGSIP--NLETLDLSNNMLS 153

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 564389402  306 -SVPSLIAGLGRLLTLWLDNNRIR-YLPDSIVELTGLEELVLQGNQ-IAVLPDNFGQL 360
Cdd:PLN00113  154 gEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQlVGQIPRELGQM 211
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 107-350 7.66e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 49.28  E-value: 7.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  107 HHLTELDVSHNRLTILGAEVV-SALR---ELRKLNLSHNQLPALPAQLGALahleeldvsfnrlahlPDSFSCLNHLRTL 182
Cdd:cd00116    23 LCLQVLRLEGNTLGEEAAKALaSALRpqpSLKELCLSLNETGRIPRGLQSL----------------LQGLTKGCGLQEL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  183 DVDHNQLTAfpqqllqlaaleeldvssnRLRGLPEDISALRALKILWLSGAELG-----TLPSGFCELA-SLESLMLDNN 256
Cdd:cd00116    87 DLSDNALGP-------------------DGCGVLESLLRSSSLQELKLNNNGLGdrglrLLAKGLKDLPpALEKLVLGRN 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  257 GL-----QALPDEFSRLQRLKMLNLSSN---------LFEEFPA------------------------ALLPLAGLEELY 298
Cdd:cd00116   148 RLegascEALAKALRANRDLKELNLANNgigdagiraLAEGLKAncnlevldlnnngltdegasalaeTLASLKSLEVLN 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564389402  299 LSRNQLTSV------PSLIAGLGRLLTLWLDNNRI---------RYLPDSIVeltgLEELVLQGNQI 350
Cdd:cd00116   228 LGDNNLTDAgaaalaSALLSPNISLLTLSLSCNDItddgakdlaEVLAEKES----LLELDLRGNKF 290
COR pfam16095
C-terminal of Roc, COR, domain; The C-terminal of Roc domain, COR, along with Roc functions as ...
 656-902 6.07e-05

C-terminal of Roc, COR, domain; The C-terminal of Roc domain, COR, along with Roc functions as the putative regulator of kinase activity. It functions as a proper GTP-binding protein with a low GTPase activity somehow stimulating the kinase activity.


Pssm-ID: 406489  Cd Length: 196  Bit Score: 44.93  E-value: 6.07e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   656 PRSWQVLEElHFQPPQAQRLWLSWWDSARLGLQAGLT-EDRLQSALSYLHESGKLLYFEDSPALKEHVFHNLTRLID--- 731
Cdd:pfam16095    1 PKSWLAVRE-ALEKERQKKPYISYEEYRKICAENGIDdEEDQDTLLEFLHDLGVLLYFQDDPGLRDIVILNPQWLTNavy 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   732 -ILNVFFQRdaslllhklllgtNGEGEGEGESFPTIAvptpgQDPLRATQLHHyvegfllhgllpaHIIRLLlkphvqaq 810
Cdd:pfam16095   80 rVLDSKHVL-------------NNNGILTHEDLEQIW-----KDPGYPRELHP-------------YLLRLM-------- 120

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   811 qdlqlllellEKMGLCYCLNKPKgkplNGSaawYKFPCYVQNEVPHAEAWINGTNlagqsfvaeqLQIEYSFPFtFPPGL 890
Cdd:pfam16095  121 ----------EKFELCYELPGDE----EGT---YLVPQLLPENPPELYDWDEENN----------LELRYQYDF-LPKGI 172

                          250
                   ....*....|..
gi 564389402   891 FARYSVQINSHV 902
Cdd:pfam16095  173 FSRLIVRLHKFI 184
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 62-191 1.65e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.04  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   62 EVLNLGNNGLED-----VPEGLGSALGSLRVLVLRRNRF--ARLPPAVAELGHH--LTELDVSHNRLTILG----AEVVS 128
Cdd:cd00116   111 QELKLNNNGLGDrglrlLAKGLKDLPPALEKLVLGRNRLegASCEALAKALRANrdLKELNLANNGIGDAGiralAEGLK 190

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564389402  129 ALRELRKLNLSHNQL-----PALPAQLGALAHLEELDVSFNRL-----AHLPDSFSCLNH-LRTLDVDHNQLTA 191
Cdd:cd00116   191 ANCNLEVLDLNNNGLtdegaSALAETLASLKSLEVLNLGDNNLtdagaAALASALLSPNIsLLTLSLSCNDITD 264
PLN03150 PLN03150
hypothetical protein; Provisional
 61-179 3.03e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.81  E-value: 3.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   61 IEVLNLGNNGLEDVPEGLGSALGSLRVLVLRRNRF-ARLPPAVAELGHhLTELDVSHNRLTILGAEVVSALRELRKLNLS 139
Cdd:PLN03150  420 IDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIrGNIPPSLGSITS-LEVLDLSYNSFNGSIPESLGQLTSLRILNLN 498

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 564389402  140 HNQLPA-LPAQLGA-LAHLEELDVSFNR-LAHLPDSFSCLNHL 179
Cdd:PLN03150  499 GNSLSGrVPAALGGrLLHRASFNFTDNAgLCGIPGLRACGPHL 541
PTZ00132 PTZ00132
GTP-binding nuclear protein Ran; Provisional
 398-480 1.55e-03

GTP-binding nuclear protein Ran; Provisional


Pssm-ID: 240284 [Multi-domain]  Cd Length: 215  Bit Score: 41.22  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  398 SQPAVQPRLKLLLMGHKAAGKTLL--RHcLTedkveggqggGDKEKSYLPfpplgSKGIEVTSWTADASRG-LRFIVYDL 474
Cdd:PTZ00132    2 QQMDEVPEFKLILVGDGGVGKTTFvkRH-LT----------GEFEKKYIP-----TLGVEVHPLKFYTNCGpICFNVWDT 65


                  ....*.
gi 564389402  475 AGDESY 480
Cdd:PTZ00132   66 AGQEKF 71
LRR_8 pfam13855
Leucine rich repeat;
155-190 2.14e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 2.14e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 564389402   155 HLEELDVSFNRLAHL-PDSFSCLNHLRTLDVDHNQLT 190
Cdd:pfam13855    2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLT 38
LRR_8 pfam13855
Leucine rich repeat;
223-281 2.48e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 2.48e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564389402   223 RALKILWLSGAELGTLPSG-FCELASLESLMLDNNGLQAL-PDEFSRLQRLKMLNLSSNLF 281
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 84-350 2.54e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.31  E-value: 2.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402   84 SLRVLVLRRNRFARLPPAVAELGHHLT--ELDVSHNRLTILGA---EVVSALRELRKLNLSHNQLPALpaQLGALAHLEE 158
Cdd:COG5238    89 LLVVDWEGAEEVSPVALAETATAVATPppDLRRIMAKTLEDSLilyLALPRRINLIQVLKDPLGGNAV--HLLGLAARLG 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  159 LDVsfnrlAHLPDSFSCLNHLRTLDVDHNQLtafpqqllqlaaleeldvSSNRLRGLPEDISALRALKILWLSGAELG-- 236
Cdd:COG5238   167 LLA-----AISMAKALQNNSVETVYLGCNQI------------------GDEGIEELAEALTQNTTVTTLWLKRNPIGde 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564389402  237 ---TLPSGFCELASLESLMLDNN-----GLQALPDEFSRLQRLKMLNLSSNLFEEFPAALLP--LAG---LEELYLSRNQ 303
Cdd:COG5238   224 gaeILAEALKGNKSLTTLDLSNNqigdeGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAkaLQGnttLTSLDLSVNR 303

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 564389402  304 LT--SVPSLIAGLGR---LLTLWLDNNRI-----RYLPDSIVELTGLEELVLQGNQI 350
Cdd:COG5238   304 IGdeGAIALAEGLQGnktLHTLNLAYNGIgaqgaIALAKALQENTTLHSLDLSDNQI 360
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 294-332 8.98e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 8.98e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564389402   294 LEELYLSRNQLTSVPSLiAGLGRLLTLWL-DNNRIRYLPD 332
Cdd:pfam12799    3 LEVLDLSNNQITDIPPL-AKLPNLETLDLsGNNKITDLSD 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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