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Conserved domains on  [gi|564393225|ref|XP_006254696|]
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DAP3-binding cell death enhancer 1 isoform X1 [Rattus norvegicus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11434433)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
267-424 1.39e-40

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 146.61  E-value: 1.39e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564393225 267 DYTAAFSYFQKAADRGYSKAQYNVGLCLEHGRGTPRDLSKAVLFYHLAAVQGHSLAQYRYARCLLQSPGSMSDPErqRAV 346
Cdd:COG0790   82 DYEKALEWFEKAAEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPA--KAA 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564393225 347 SLLKQAADSGLTEAQAFLGVLFT--KEPHLDEQKAVKYFWLAASNGDSQSRFHLGICYEKGLGVQRNLGEAVKCYQKSAA 424
Cdd:COG0790  160 EWYRKAAEQGDADAQYNLGVLYEngRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAE 239
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
267-424 1.39e-40

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 146.61  E-value: 1.39e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564393225 267 DYTAAFSYFQKAADRGYSKAQYNVGLCLEHGRGTPRDLSKAVLFYHLAAVQGHSLAQYRYARCLLQSPGSMSDPErqRAV 346
Cdd:COG0790   82 DYEKALEWFEKAAEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPA--KAA 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564393225 347 SLLKQAADSGLTEAQAFLGVLFT--KEPHLDEQKAVKYFWLAASNGDSQSRFHLGICYEKGLGVQRNLGEAVKCYQKSAA 424
Cdd:COG0790  160 EWYRKAAEQGDADAQYNLGVLYEngRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAE 239
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 284-319 4.82e-08

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 49.09  E-value: 4.82e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 564393225   284 SKAQYNVGLCLEHGRGTPRDLSKAVLFYHLAAVQGH 319
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 284-318 1.86e-06

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 44.43  E-value: 1.86e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 564393225  284 SKAQYNVGLCLEHGRGTPRDLSKAVLFYHLAAVQG 318
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
267-424 1.39e-40

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 146.61  E-value: 1.39e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564393225 267 DYTAAFSYFQKAADRGYSKAQYNVGLCLEHGRGTPRDLSKAVLFYHLAAVQGHSLAQYRYARCLLQSPGSMSDPErqRAV 346
Cdd:COG0790   82 DYEKALEWFEKAAEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPA--KAA 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564393225 347 SLLKQAADSGLTEAQAFLGVLFT--KEPHLDEQKAVKYFWLAASNGDSQSRFHLGICYEKGLGVQRNLGEAVKCYQKSAA 424
Cdd:COG0790  160 EWYRKAAEQGDADAQYNLGVLYEngRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAE 239
TPR COG0790
TPR repeat [General function prediction only];
222-438 5.20e-40

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 145.07  E-value: 5.20e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564393225 222 PGGKNEQDKPKALPLEEAVTSIQQLFQLSVAIAFNFLGTENIKTGDYTAAFSYFQKAADRGYSKAQYNVGLCLEHGRGTP 301
Cdd:COG0790    1 LALAAAAAAAAAAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564393225 302 RDLSKAVLFYHLAAVQGHSLAQYRYARCLLQSPGSMSDPERqrAVSLLKQAADSGLTEAQAFLGVLFTKEPHL--DEQKA 379
Cdd:COG0790   81 KDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGLGVPQDYAK--ALEWYEKAAEQGDADAQYNLGLLYLNGEGVpkDPAKA 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 564393225 380 VKYFWLAASNGDSQSRFHLGICYEKGLGVQRNLGEAVKCYQKSAAMGNEPAQERLRTLF 438
Cdd:COG0790  159 AEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLY 217
TPR COG0790
TPR repeat [General function prediction only];
267-389 5.23e-28

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 111.94  E-value: 5.23e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564393225 267 DYTAAFSYFQKAADRGYSKAQYNVGLCLEHGRGTPRDLSKAVLFYHLAAVQGHSLAQYRYARCLLQSPGSMSDPErqRAV 346
Cdd:COG0790  118 DYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPA--KAL 195

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 564393225 347 SLLKQAADSGLTEAQAFLGVLFT--KEPHLDEQKAVKYFWLAASN 389
Cdd:COG0790  196 EWYRKAAEQGDADAQYNLGRLYLngEGVEKDLEKALRWLRKAAEQ 240
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 284-319 4.82e-08

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 49.09  E-value: 4.82e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 564393225   284 SKAQYNVGLCLEHGRGTPRDLSKAVLFYHLAAVQGH 319
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 392-427 2.18e-07

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 47.17  E-value: 2.18e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 564393225   392 SQSRFHLGICYEKGLGVQRNLGEAVKCYQKSAAMGN 427
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
252-449 9.69e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.01  E-value: 9.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564393225 252 AIAFNFLGTENIKTGDYTAAFSYFQKAA--DRGYSKAQYNVGLCLEHgRGtprDLSKAVLFYH--LAAVQGHSLAQYRYA 327
Cdd:COG0457    8 AEAYNNLGLAYRRLGRYEEAIEDYEKALelDPDDAEALYNLGLAYLR-LG---RYEEALADYEqaLELDPDDAEALNNLG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564393225 328 RCLLQspgsMSDPErqRAVSLLKQA--ADSGLTEAQAFLGVLFTKEPHLDEqkAVKYF--WLAASNGDSQSRFHLGICYE 403
Cdd:COG0457   84 LALQA----LGRYE--EALEDYDKAleLDPDDAEALYNLGLALLELGRYDE--AIEAYerALELDPDDADALYNLGIALE 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 564393225 404 KglgvQRNLGEAVKCYQKSAAMGNEPAQERLRTLFNVEAAGPSHLA 449
Cdd:COG0457  156 K----LGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLL 197
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 284-318 1.86e-06

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 44.43  E-value: 1.86e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 564393225  284 SKAQYNVGLCLEHGRGTPRDLSKAVLFYHLAAVQG 318
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 392-426 6.91e-06

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 42.89  E-value: 6.91e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 564393225  392 SQSRFHLGICYEKGLGVQRNLGEAVKCYQKSAAMG 426
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
236-383 1.58e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 40.38  E-value: 1.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564393225 236 LEEAVTSIQQLFQL--SVAIAFNFLGTENIKTGDYTAAFSYFQKA--ADRGYSKAQYNVGLCLEHgRGtprDLSKAVLFY 311
Cdd:COG0457   24 YEEAIEDYEKALELdpDDAEALYNLGLAYLRLGRYEEALADYEQAleLDPDDAEALNNLGLALQA-LG---RYEEALEDY 99

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564393225 312 H--LAAVQGHSLAQYRYARCLLQSpGsmsdpERQRAVSLLKQA--ADSGLTEAQAFLGVLFTKEPHLDEqkAVKYF 383
Cdd:COG0457  100 DkaLELDPDDAEALYNLGLALLEL-G-----RYDEAIEAYERAleLDPDDADALYNLGIALEKLGRYEE--ALELL 167
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 236-438 2.00e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.10  E-value: 2.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564393225 236 LEEAVTSIQQLFQL---SVAIAFNfLGTENIKTGDYTAAFSYFQKAADRGYSKAQYNVGLCLEHGRGtpRDLSKAVLFYH 312
Cdd:COG2956   24 PDKAIDLLEEALELdpeTVEAHLA-LGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKA--GLLDRAEELLE 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564393225 313 --LAAVQGHSLAQYRYARCLLQSpgsmSDPErqRAVSLLKQAADSGLTEAQAF--LGVLFTKEPHLDeqKAVKYFW--LA 386
Cdd:COG2956  101 klLELDPDDAEALRLLAEIYEQE----GDWE--KAIEVLERLLKLGPENAHAYceLAELYLEQGDYD--EAIEALEkaLK 172

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 564393225 387 ASNGDSQSRFHLGICYEKglgvQRNLGEAVKCYQK--SAAMGNEPAQERLRTLF 438
Cdd:COG2956  173 LDPDCARALLLLAELYLE----QGDYEEAIAALERalEQDPDYLPALPRLAELY 222
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 246-421 2.83e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 39.71  E-value: 2.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564393225 246 LFQLSVAIAFNFLGTENIKTGDYTAAFSYFQKAA--DRGYSKAQYNVGLCLEHgRGtprDLSKAVLFYH--LAAVQGHSL 321
Cdd:COG2956    2 LLPVAAALGWYFKGLNYLLNGQPDKAIDLLEEALelDPETVEAHLALGNLYRR-RG---EYDRAIRIHQklLERDPDRAE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564393225 322 AQYRYARCLLQSpGsmsdpERQRAVSLLKQAADSGLTEAQAF--LGVLFTKEphLDEQKAVKYF--WLAASNGDSQSRFH 397
Cdd:COG2956   78 ALLELAQDYLKA-G-----LLDRAEELLEKLLELDPDDAEALrlLAEIYEQE--GDWEKAIEVLerLLKLGPENAHAYCE 149

                        170       180
                 ....*....|....*....|....
gi 564393225 398 LGICYEKglgvQRNLGEAVKCYQK 421
Cdd:COG2956  150 LAELYLE----QGDYDEAIEALEK 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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