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Conserved domains on  [gi|568907812|ref|XP_006496617|]
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beta-galactosidase-1-like protein isoform X1 [Mus musculus]

Protein Classification

glycoside hydrolase family 35 protein( domain architecture ID 10472897)

glycoside hydrolase family 35 protein similar to Xanthomonas phaseoli beta-galactosidase that catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides

CAZY:  GH35
EC:  3.2.1.-
Gene Ontology:  GO:0004565|GO:0005975
SCOP:  4003303

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Glyco_hydro_35 pfam01301
Glycosyl hydrolases family 35;
34-349 5.77e-174

Glycosyl hydrolases family 35;


:

Pssm-ID: 396048 [Multi-domain]  Cd Length: 316  Bit Score: 497.55  E-value: 5.77e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812   34 RFLLDGVPFRYVSGSLHYFRVPPVLWADRLLKMQLSGLNAVQFYVPWNYHEPEPGIYNFNGSRDLIAFLNEAAKVNLLVI 113
Cdd:pfam01301   1 SFLIDGKRFRLISGSIHYFRIPPEMWPDRLQKAKALGLNAIETYVFWNLHEPEPGQYDFSGILDLVKFIKLAQEAGLYVI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812  114 LRPGPYICAEWEMGGLPSWLLRNPNIHLRTSDPAFLEAVDSWFKVLLPKIYPFLYHNGGNIISIQVENEYGSYkACDFKY 193
Cdd:pfam01301  81 LRPGPYICAEWDFGGLPAWLLTVPGIRLRTSDPPFLEAVERYLTALLPKMKPLQATNGGPIIMVQVENEYGSY-GVDKAY 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812  194 MRHLAGLFRALLGDKILLFTTDGPHG--LRCGSLQG--LYTTIDFGPADNVTRIFSLLREYEPHGPLVNSEYYTGWLDYW 269
Cdd:pfam01301 160 LRALRKAYKEWGADMALLFTTDGPWGmcLQCGDLPGpdIYATNGFGCGANPPSNFKLLRPFSPNKPLMWSEFWTGWFDHW 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812  270 GQNHSTRSSPAVAQGLEKMLKLGASVNMYMFHGGTNFGYWNGADEKGrflPITTSYDYDAPISEAGDPTPKLFAIRNVIS 349
Cdd:pfam01301 240 GGPHAIRPAEDIAFEVARFLAKNSSVNLYMFHGGTNFGFTNGANFYG---PQTTSYDYDAPIDEAGDPTPKYGHLKDLIT 316
 
Name Accession Description Interval E-value
Glyco_hydro_35 pfam01301
Glycosyl hydrolases family 35;
34-349 5.77e-174

Glycosyl hydrolases family 35;


Pssm-ID: 396048 [Multi-domain]  Cd Length: 316  Bit Score: 497.55  E-value: 5.77e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812   34 RFLLDGVPFRYVSGSLHYFRVPPVLWADRLLKMQLSGLNAVQFYVPWNYHEPEPGIYNFNGSRDLIAFLNEAAKVNLLVI 113
Cdd:pfam01301   1 SFLIDGKRFRLISGSIHYFRIPPEMWPDRLQKAKALGLNAIETYVFWNLHEPEPGQYDFSGILDLVKFIKLAQEAGLYVI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812  114 LRPGPYICAEWEMGGLPSWLLRNPNIHLRTSDPAFLEAVDSWFKVLLPKIYPFLYHNGGNIISIQVENEYGSYkACDFKY 193
Cdd:pfam01301  81 LRPGPYICAEWDFGGLPAWLLTVPGIRLRTSDPPFLEAVERYLTALLPKMKPLQATNGGPIIMVQVENEYGSY-GVDKAY 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812  194 MRHLAGLFRALLGDKILLFTTDGPHG--LRCGSLQG--LYTTIDFGPADNVTRIFSLLREYEPHGPLVNSEYYTGWLDYW 269
Cdd:pfam01301 160 LRALRKAYKEWGADMALLFTTDGPWGmcLQCGDLPGpdIYATNGFGCGANPPSNFKLLRPFSPNKPLMWSEFWTGWFDHW 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812  270 GQNHSTRSSPAVAQGLEKMLKLGASVNMYMFHGGTNFGYWNGADEKGrflPITTSYDYDAPISEAGDPTPKLFAIRNVIS 349
Cdd:pfam01301 240 GGPHAIRPAEDIAFEVARFLAKNSSVNLYMFHGGTNFGFTNGANFYG---PQTTSYDYDAPIDEAGDPTPKYGHLKDLIT 316
PLN03059 PLN03059
beta-galactosidase; Provisional
28-347 8.91e-47

beta-galactosidase; Provisional


Pssm-ID: 166698 [Multi-domain]  Cd Length: 840  Bit Score: 177.12  E-value: 8.91e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812  28 VDREHDRFLLDGVPFRYVSGSLHYFRVPPVLWADRLLKMQLSGLNAVQFYVPWNYHEPEPGIYNFNGSRDLIAFLNEAAK 107
Cdd:PLN03059  30 VSYDHRAFIINGQRRILISGSIHYPRSTPEMWPDLIQKAKDGGLDVIQTYVFWNGHEPSPGNYYFEDRYDLVKFIKVVQA 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812 108 VNLLVILRPGPYICAEWEMGGLPSWLLRNPNIHLRTSDPAFLEAVDSWFK--VLLPKIYPFLYHNGGNIISIQVENEYGS 185
Cdd:PLN03059 110 AGLYVHLRIGPYICAEWNFGGFPVWLKYVPGIEFRTDNGPFKAAMQKFTEkiVDMMKSEKLFEPQGGPIILSQIENEYGP 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812 186 YK---ACDFKYMRHLAGLFRALLGDK---ILLFTTDGPHGLrCGSLQGLYTTiDFGPAdnvtrifsllREYEPHgplVNS 259
Cdd:PLN03059 190 VEweiGAPGKAYTKWAADMAVKLGTGvpwVMCKQEDAPDPV-IDTCNGFYCE-NFKPN----------KDYKPK---MWT 254
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812 260 EYYTGWLDYWGQNHSTRSSPAVAQGLEKMLKLGAS-VNMYMFHGGTNFGYWNGadekGRFlpITTSYDYDAPISEAGDPT 338
Cdd:PLN03059 255 EAWTGWYTEFGGAVPNRPAEDLAFSVARFIQNGGSfINYYMYHGGTNFGRTAG----GPF--IATSYDYDAPLDEYGLPR 328
                        330
                 ....*....|
gi 568907812 339 -PKLFAIRNV 347
Cdd:PLN03059 329 ePKWGHLRDL 338
GanA COG1874
Beta-galactosidase GanA [Carbohydrate transport and metabolism];
34-354 1.18e-42

Beta-galactosidase GanA [Carbohydrate transport and metabolism];


Pssm-ID: 441478 [Multi-domain]  Cd Length: 609  Bit Score: 162.79  E-value: 1.18e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812  34 RFLLDGvPFRYVSGSLHYFRVPPVLWADRLLKMQLSGLNAVQ-FYVPWNYHEPEPGIYNFNGsrdLIAFLNEAAKVNLLV 112
Cdd:COG1874    2 TFLLDK-PFLILGGDYHPERWPPEVWAEDIRLMKAAGLNTVRiGYFAWNLHEPEEGVFDFDW---LDRFIDLLHEAGLKV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812 113 ILRPGPYIcaewemggLPSWLLRN-PNI----------------HLRTSDPAFLEAVDSWFKVLLPKiypflYHNGGNII 175
Cdd:COG1874   78 ILRTPTAA--------PPAWLLKKyPEIlpvdadgrrrgfgsrrHYCPSSPVYREAARRIVRALAER-----YGDHPAVI 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812 176 SIQVENEYGSYKAC--------------------------------------------------------DFK------- 192
Cdd:COG1874  145 MWQVDNEYGSYDYCdacaaafrdwlrerygtldalneawgtafwsqrytdwdeiepprltpttanpslrlDFRrfssdqv 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812 193 --YMRHLAGLFRAlLGDKILLFTTDgpHGLRCGS-LQGLYTTIDFGPADNVTRIFS-----------LLREYEPHGPLVN 258
Cdd:COG1874  225 leYLRAQRDILRE-AGPDVPVTTNF--MGPFPGLdYWKLARDLDVVSWDNYPDGSAadpdeiafahdLMRGLKGGGPFMV 301
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812 259 SEYYTGWLDyWGQNHSTRSSPAVAQGLEKMLKLGAS-VNMYMFhggtnfgywngadekgRFLPITTSYDYDAPISEAGDP 337
Cdd:COG1874  302 MEQWPGWVN-WGPYNPAKRPGQLRLWSLQALAHGADgVNYFQW----------------RPSRGGTEYDHDAPLDHAGRP 364
                        410
                 ....*....|....*..
gi 568907812 338 TPKLFAIRNVISKFQEI 354
Cdd:COG1874  365 TRKFREVRELGAELARL 381
 
Name Accession Description Interval E-value
Glyco_hydro_35 pfam01301
Glycosyl hydrolases family 35;
34-349 5.77e-174

Glycosyl hydrolases family 35;


Pssm-ID: 396048 [Multi-domain]  Cd Length: 316  Bit Score: 497.55  E-value: 5.77e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812   34 RFLLDGVPFRYVSGSLHYFRVPPVLWADRLLKMQLSGLNAVQFYVPWNYHEPEPGIYNFNGSRDLIAFLNEAAKVNLLVI 113
Cdd:pfam01301   1 SFLIDGKRFRLISGSIHYFRIPPEMWPDRLQKAKALGLNAIETYVFWNLHEPEPGQYDFSGILDLVKFIKLAQEAGLYVI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812  114 LRPGPYICAEWEMGGLPSWLLRNPNIHLRTSDPAFLEAVDSWFKVLLPKIYPFLYHNGGNIISIQVENEYGSYkACDFKY 193
Cdd:pfam01301  81 LRPGPYICAEWDFGGLPAWLLTVPGIRLRTSDPPFLEAVERYLTALLPKMKPLQATNGGPIIMVQVENEYGSY-GVDKAY 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812  194 MRHLAGLFRALLGDKILLFTTDGPHG--LRCGSLQG--LYTTIDFGPADNVTRIFSLLREYEPHGPLVNSEYYTGWLDYW 269
Cdd:pfam01301 160 LRALRKAYKEWGADMALLFTTDGPWGmcLQCGDLPGpdIYATNGFGCGANPPSNFKLLRPFSPNKPLMWSEFWTGWFDHW 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812  270 GQNHSTRSSPAVAQGLEKMLKLGASVNMYMFHGGTNFGYWNGADEKGrflPITTSYDYDAPISEAGDPTPKLFAIRNVIS 349
Cdd:pfam01301 240 GGPHAIRPAEDIAFEVARFLAKNSSVNLYMFHGGTNFGFTNGANFYG---PQTTSYDYDAPIDEAGDPTPKYGHLKDLIT 316
PLN03059 PLN03059
beta-galactosidase; Provisional
28-347 8.91e-47

beta-galactosidase; Provisional


Pssm-ID: 166698 [Multi-domain]  Cd Length: 840  Bit Score: 177.12  E-value: 8.91e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812  28 VDREHDRFLLDGVPFRYVSGSLHYFRVPPVLWADRLLKMQLSGLNAVQFYVPWNYHEPEPGIYNFNGSRDLIAFLNEAAK 107
Cdd:PLN03059  30 VSYDHRAFIINGQRRILISGSIHYPRSTPEMWPDLIQKAKDGGLDVIQTYVFWNGHEPSPGNYYFEDRYDLVKFIKVVQA 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812 108 VNLLVILRPGPYICAEWEMGGLPSWLLRNPNIHLRTSDPAFLEAVDSWFK--VLLPKIYPFLYHNGGNIISIQVENEYGS 185
Cdd:PLN03059 110 AGLYVHLRIGPYICAEWNFGGFPVWLKYVPGIEFRTDNGPFKAAMQKFTEkiVDMMKSEKLFEPQGGPIILSQIENEYGP 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812 186 YK---ACDFKYMRHLAGLFRALLGDK---ILLFTTDGPHGLrCGSLQGLYTTiDFGPAdnvtrifsllREYEPHgplVNS 259
Cdd:PLN03059 190 VEweiGAPGKAYTKWAADMAVKLGTGvpwVMCKQEDAPDPV-IDTCNGFYCE-NFKPN----------KDYKPK---MWT 254
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812 260 EYYTGWLDYWGQNHSTRSSPAVAQGLEKMLKLGAS-VNMYMFHGGTNFGYWNGadekGRFlpITTSYDYDAPISEAGDPT 338
Cdd:PLN03059 255 EAWTGWYTEFGGAVPNRPAEDLAFSVARFIQNGGSfINYYMYHGGTNFGRTAG----GPF--IATSYDYDAPLDEYGLPR 328
                        330
                 ....*....|
gi 568907812 339 -PKLFAIRNV 347
Cdd:PLN03059 329 ePKWGHLRDL 338
GanA COG1874
Beta-galactosidase GanA [Carbohydrate transport and metabolism];
34-354 1.18e-42

Beta-galactosidase GanA [Carbohydrate transport and metabolism];


Pssm-ID: 441478 [Multi-domain]  Cd Length: 609  Bit Score: 162.79  E-value: 1.18e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812  34 RFLLDGvPFRYVSGSLHYFRVPPVLWADRLLKMQLSGLNAVQ-FYVPWNYHEPEPGIYNFNGsrdLIAFLNEAAKVNLLV 112
Cdd:COG1874    2 TFLLDK-PFLILGGDYHPERWPPEVWAEDIRLMKAAGLNTVRiGYFAWNLHEPEEGVFDFDW---LDRFIDLLHEAGLKV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812 113 ILRPGPYIcaewemggLPSWLLRN-PNI----------------HLRTSDPAFLEAVDSWFKVLLPKiypflYHNGGNII 175
Cdd:COG1874   78 ILRTPTAA--------PPAWLLKKyPEIlpvdadgrrrgfgsrrHYCPSSPVYREAARRIVRALAER-----YGDHPAVI 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812 176 SIQVENEYGSYKAC--------------------------------------------------------DFK------- 192
Cdd:COG1874  145 MWQVDNEYGSYDYCdacaaafrdwlrerygtldalneawgtafwsqrytdwdeiepprltpttanpslrlDFRrfssdqv 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812 193 --YMRHLAGLFRAlLGDKILLFTTDgpHGLRCGS-LQGLYTTIDFGPADNVTRIFS-----------LLREYEPHGPLVN 258
Cdd:COG1874  225 leYLRAQRDILRE-AGPDVPVTTNF--MGPFPGLdYWKLARDLDVVSWDNYPDGSAadpdeiafahdLMRGLKGGGPFMV 301
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812 259 SEYYTGWLDyWGQNHSTRSSPAVAQGLEKMLKLGAS-VNMYMFhggtnfgywngadekgRFLPITTSYDYDAPISEAGDP 337
Cdd:COG1874  302 MEQWPGWVN-WGPYNPAKRPGQLRLWSLQALAHGADgVNYFQW----------------RPSRGGTEYDHDAPLDHAGRP 364
                        410
                 ....*....|....*..
gi 568907812 338 TPKLFAIRNVISKFQEI 354
Cdd:COG1874  365 TRKFREVRELGAELARL 381
Glyco_hydro_42 pfam02449
Beta-galactosidase; This group of beta-galactosidase enzymes belong to the glycosyl hydrolase ...
52-184 4.85e-08

Beta-galactosidase; This group of beta-galactosidase enzymes belong to the glycosyl hydrolase 42 family. The enzyme catalyzes the hydrolysis of terminal, non-reducing terminal beta-D-galactosidase residues.


Pssm-ID: 396834  Cd Length: 376  Bit Score: 55.36  E-value: 4.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907812   52 FRVPPVLWADRLLKMQLSGLNAVQF-YVPWNYHEPEPGIYNFNGSRDLIAFLneaAKVNLLVILRPGpyicaeweMGGLP 130
Cdd:pfam02449   5 EQWPEETWEEDIRLMKEAGVNVVRIgIFAWAKLEPEEGKYDFEWLDEVIDLL---AKAGIKVILATP--------TAAPP 73
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568907812  131 SWLLR-NPNI----------------HLRTSDPAFLEAVDswfkvllpKIYPFL---YHNGGNIISIQVENEYG 184
Cdd:pfam02449  74 AWLVKkHPEIlpvdadgrrrgfgsrhHYCPSSPVYREYAA--------RIVEALaerYGDHPALIGWHIDNEYG 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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