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Conserved domains on  [gi|568918516|ref|XP_006500294|]
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large neutral amino acids transporter small subunit 3 isoform X3 [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 1905563)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FucP super family cl43255
Fucose permease [Carbohydrate transport and metabolism];
51-205 1.75e-05

Fucose permease [Carbohydrate transport and metabolism];


The actual alignment was detected with superfamily member COG0738:

Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 47.16  E-value: 1.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918516  51 MLNLGFTIGSFLLSattLPLGILMDRFGPRPLRLVGSACFAASCTLMALASRdtevlSPLIFLALSLNGFaGICLTFTSL 130
Cdd:COG0738   47 LLLFAFFLGYLLAS---LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS-----YPLLLLALFLLGL-GLGLLDVAA 117

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568918516 131 T--LPNMFGNLRSTFMALMIGSYASSAITFPGI-KLIYDAGVPFTVIMFTWsGLACLIFLNCALNWPAeAFPAPEEVD 205
Cdd:COG0738  118 NpyVAALGPETAASRLNLLHAFFSLGALLGPLLgGLLILLGLSLSWHLPYL-ILAVLLLLLALLFLRS-KLPEIEEEE 193
 
Name Accession Description Interval E-value
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
51-205 1.75e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 47.16  E-value: 1.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918516  51 MLNLGFTIGSFLLSattLPLGILMDRFGPRPLRLVGSACFAASCTLMALASRdtevlSPLIFLALSLNGFaGICLTFTSL 130
Cdd:COG0738   47 LLLFAFFLGYLLAS---LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS-----YPLLLLALFLLGL-GLGLLDVAA 117

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568918516 131 T--LPNMFGNLRSTFMALMIGSYASSAITFPGI-KLIYDAGVPFTVIMFTWsGLACLIFLNCALNWPAeAFPAPEEVD 205
Cdd:COG0738  118 NpyVAALGPETAASRLNLLHAFFSLGALLGPLLgGLLILLGLSLSWHLPYL-ILAVLLLLLALLFLRS-KLPEIEEEE 193
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 51-217 4.83e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 45.88  E-value: 4.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918516  51 MLNLGFTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALAsrdteVLSPLIFLALSLNGFAGICLTFTSL 130
Cdd:cd06174   32 QLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA-----PSFWLLLLGRFLLGLGSGLIDPAVL 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918516 131 TL------PNMFGNLRSTFMALMIGSYASSAITFPGIKLIYDAGVP-FTVIMFTWSGLACLIFLNCALNWPAEAFPAPEE 203
Cdd:cd06174  107 ALiadlfpERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRaVFLIAAALALLAAILLLLVVPDPPESARAKNEE 186

                        170
                 ....*....|....
gi 568918516 204 VDYTKKIKLIGLAL 217
Cdd:cd06174  187 ASSKSVLKLLKRVL 200
MFS_1 pfam07690
Major Facilitator Superfamily;
51-191 6.65e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 45.10  E-value: 6.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918516   51 MLNLGFTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASRDTEVLSPLIFLALSLNGFAGICLTFTSL 130
Cdd:pfam07690  33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIAD 112

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568918516  131 TLPnmfGNLRSTFMALMIGSYASSAITFPGIKLIYDAGVPFTVIMFTWSGLACLIFLNCAL 191
Cdd:pfam07690 113 WFP---PEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLL 170
2A0108 TIGR00886
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
 68-190 4.19e-03

nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]


Pssm-ID: 273322 [Multi-domain]  Cd Length: 354  Bit Score: 39.59  E-value: 4.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918516   68 LPLGILMDRFGPRPLRLVGSACFAASCTLMALASRDTEVLSPLIFLAlslnGFAG----ICLTFTSLTLPNM-------- 135
Cdd:TIGR00886  55 IILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVQSYSVLLLIRLFI----GIAGgsfaSCMPWISFFFPKKiqgtalgl 130

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568918516  136 ---FGNLRSTFMALMIGSYASSAITFPGIKLIYDAGVPFTVIMFTWSGL-ACLIFLNCA 190
Cdd:TIGR00886 131 aagWGNMGGGVAQFVMPPIIGSLIFGGGQPAHLAWGWAFVIVPAGILLLpALLIFFVGA 189
 
Name Accession Description Interval E-value
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
51-205 1.75e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 47.16  E-value: 1.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918516  51 MLNLGFTIGSFLLSattLPLGILMDRFGPRPLRLVGSACFAASCTLMALASRdtevlSPLIFLALSLNGFaGICLTFTSL 130
Cdd:COG0738   47 LLLFAFFLGYLLAS---LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS-----YPLLLLALFLLGL-GLGLLDVAA 117

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568918516 131 T--LPNMFGNLRSTFMALMIGSYASSAITFPGI-KLIYDAGVPFTVIMFTWsGLACLIFLNCALNWPAeAFPAPEEVD 205
Cdd:COG0738  118 NpyVAALGPETAASRLNLLHAFFSLGALLGPLLgGLLILLGLSLSWHLPYL-ILAVLLLLLALLFLRS-KLPEIEEEE 193
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
54-187 3.15e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 46.41  E-value: 3.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918516  54 LGFTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASrdtevlSPLIFLALSLNGFAGICLTFTS--LT 131
Cdd:COG2223   44 LLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAV------SYWLLLLLGLLLGIGGGGSFAVgiAL 117

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568918516 132 LPNMF-GNLRSTFMALMIGSY--ASSAITFPGIKLIYDAGVPFTviMFTWSGLACLIFL 187
Cdd:COG2223  118 VSKWFpPDRRGLALGLAAGGGnlGAAVAAFLAPLLIAAFGWRNA--FLILGILLLVVAV 174
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 51-217 4.83e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 45.88  E-value: 4.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918516  51 MLNLGFTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALAsrdteVLSPLIFLALSLNGFAGICLTFTSL 130
Cdd:cd06174   32 QLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA-----PSFWLLLLGRFLLGLGSGLIDPAVL 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918516 131 TL------PNMFGNLRSTFMALMIGSYASSAITFPGIKLIYDAGVP-FTVIMFTWSGLACLIFLNCALNWPAEAFPAPEE 203
Cdd:cd06174  107 ALiadlfpERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRaVFLIAAALALLAAILLLLVVPDPPESARAKNEE 186

                        170
                 ....*....|....
gi 568918516 204 VDYTKKIKLIGLAL 217
Cdd:cd06174  187 ASSKSVLKLLKRVL 200
MFS_1 pfam07690
Major Facilitator Superfamily;
51-191 6.65e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 45.10  E-value: 6.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918516   51 MLNLGFTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASRDTEVLSPLIFLALSLNGFAGICLTFTSL 130
Cdd:pfam07690  33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIAD 112

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568918516  131 TLPnmfGNLRSTFMALMIGSYASSAITFPGIKLIYDAGVPFTVIMFTWSGLACLIFLNCAL 191
Cdd:pfam07690 113 WFP---PEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLL 170
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 51-187 8.52e-05

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 44.88  E-value: 8.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918516  51 MLNLGFTIGSFLLsattlplGILMDRFGPRPLRLVGSACFAASCTLMALASRDTEVLSPLIFLalslngfAGICLTFTSL 130
Cdd:cd17365  214 LLNIGGVIGSLLL-------GWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFL-------AGACVNGAQV 279

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568918516 131 TLPNMFGNL-----RSTFMALMIGSYASSAITFPGI-KLIYDAGVPFTVIMFTWSGLACLIFL 187
Cdd:cd17365  280 GLYALAARFyptevRATGVGWALGVGRLGAILGPLLgGLLLAAGLGPESVFLALAIPAALGAL 342
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
54-187 1.38e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 44.09  E-value: 1.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918516  54 LGFTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASrdtevlSPLIFLAL-SLNGFA-GICLTFTSLT 131
Cdd:COG2271   49 LLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFAT------SFWQLLLLrFLLGLGeAGFFPAALKL 122

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568918516 132 LPNMF-GNLRSTFMAL-MIGSYASSAITFP-GIKLIYDAGVPftvIMFTWSGLACLIFL 187
Cdd:COG2271  123 IAEWFpPKERGRALGIfNAGGPLGGALAPPlLGWLLAAFGWR---AAFLILGLPGLLLA 178
MFS_Mch1p_like cd17354
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ...
 46-217 1.44e-04

Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340912 [Multi-domain]  Cd Length: 385  Bit Score: 44.16  E-value: 1.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918516  46 DQQEKMLnlgFTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALA-SRDTEVLS-PLIFLALSLNGFAGI 123
Cdd:cd17354   36 SQQQNNL---LSVAKDLGYLVGPLLGLLSDRLGPWLLLLIGAILFFPGYGVLWLVvTGLISDLSfWLMCLCFFLIGNSTS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918516 124 CLTFTSLTLPN-MFGNLRSTFMALMIGSYA-SSAITFPGIKLIYDAGVPFTVIMFTWsglacLIFLNCALNWPAEAFPAP 201
Cdd:cd17354  113 SLYTAALVTCAkNFPESRGLAIGIPKGCYGlSGAIGSQLYKALFFHDSARVFLFLAV-----LPAVVGLLAWFSVRIVSI 187

                        170
                 ....*....|....*.
gi 568918516 202 EEVDYTKKIKLIGLAL 217
Cdd:cd17354  188 EEGEFLKDIDFWLLFI 203
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 54-159 1.86e-04

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 43.80  E-value: 1.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918516  54 LGFTIGsFLLSATTLPL-GILMDRFGPRPLRLVGSACFAASCTLMALASrdtevlSP----LIFLALSLNGFAGICLTFT 128
Cdd:cd17355   42 LAFTVG-LLAFGLAQPFvGRLLDRFGPRRVMLLGLLLLAAGLVLLALAT------SLwqlyLLWGLLGGGGAGTLAAVAF 114

                         90       100       110
                 ....*....|....*....|....*....|.
gi 568918516 129 SLTLPNMFGNLRSTFMALMIGSYASSAITFP 159
Cdd:cd17355  115 ATVAAWWFERRRGLALGILTAGGGLGSLVFL 145
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
54-151 2.99e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 43.04  E-value: 2.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918516  54 LGFTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASRDTEVLSPLIFLALSLNGFAGICLTFTSLTLP 133
Cdd:COG2814  247 LLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326

                         90
                 ....*....|....*...
gi 568918516 134 nmfGNLRSTFMALMIGSY 151
Cdd:COG2814  327 ---PEARGRASGLYNSAF 341
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 52-161 3.12e-04

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 43.08  E-value: 3.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918516  52 LNLGFTIGSFLLsattlplGILMDRFGPRPLRLVGSACFAASCTLMALASrdtevLSPLIFLALSLNGFA-GICLTFTSL 130
Cdd:cd17333   40 QNAGYLIGSLLA-------GFLMKRLGRRRTLILGLLLISLALALIFATP-----SIYLFVVLMFLAGLGaGILDTGANT 107

                         90       100       110
                 ....*....|....*....|....*....|.
gi 568918516 131 TLPNMFGNLRSTFMALMIGSYASSAITFPGI 161
Cdd:cd17333  108 FVGALFEESSATRLNVLHGFFGLGALIGPLI 138
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 43-123 3.32e-04

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 42.98  E-value: 3.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918516  43 TSCDQQEKMLNLGFTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASRdtevlSPLIFLALSlnGFAG 122
Cdd:cd17353   31 SALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAIS-----LPLLFLGYG--VLGG 103


                 .
gi 568918516 123 I 123
Cdd:cd17353  104 I 104
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 51-158 4.05e-04

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 42.61  E-value: 4.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918516  51 MLNLGFTIGSfllsattLPLGILMDRFGPRPLRLVGSACFAASCTLMALASRDTEVLSPLIFLAL--------------- 115
Cdd:cd17475   39 ALNLGVAVSM-------LPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAgygsvqpgggraimr 111

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568918516 116 ----SLNGFA-GICLT-------FTSLTLPNMFG--NLRSTFMALMIGSYASSAITF 158
Cdd:cd17475  112 wfppRERGLAmGIRQTgvplggaLAAALLPPLALhyGWRAAFVVAGLVSILAAVLFW 168
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 58-131 4.06e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 42.95  E-value: 4.06e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568918516  58 IGSFLLSattlPL-GILMDRFGPRPLRLVGSACFAASCTLMALASRDTEVlsPLIFLALSLNGFaGICLTFTSLT 131
Cdd:cd17503  225 LASAILS----PLvGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSL--WLIILPLFIRGL-GMGLVFMPLN 292
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
54-161 4.36e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 42.65  E-value: 4.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918516  54 LGFTIGSFLLSA--TTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASrdtevlSPLIFLALS-LNGFAGICLTFTSL 130
Cdd:COG2814   47 AGLVVTAYLLGAalGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP------SLWLLLAARfLQGLGAGALFPAAL 120

                         90       100       110
                 ....*....|....*....|....*....|...
gi 568918516 131 TL-PNMF-GNLRSTFMALMIGSYASSAITFPGI 161
Cdd:COG2814  121 ALiADLVpPERRGRALGLLGAGLGLGPALGPLL 153
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 54-131 5.06e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 42.55  E-value: 5.06e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568918516  54 LGFTIGSFLLSATTlplGILMDRFGPRPLRLVGSACFAASCTLMALASRDTEVlsPLIFLALSLNGFaGICLTFTSLT 131
Cdd:cd17321  211 LPLALAMLVAAPLA---GRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSV--WLLLPGLVLLGL-GLGLFATPLT 282
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 54-149 1.62e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 41.00  E-value: 1.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918516  54 LGFTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASRDTEVLSPLIFLALSLNGFAGICLTFTSLTLP 133
Cdd:cd17324   38 LLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVP 117

                         90
                 ....*....|....*.
gi 568918516 134 nmfGNLRSTFMALMIG 149
Cdd:cd17324  118 ---PEKRGRAIGLVFS 130
MFS_1 pfam07690
Major Facilitator Superfamily;
56-159 1.70e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 40.86  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918516   56 FTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASRDTEVLSPLIFLALSLNGFAGICLTFTSLTLPNM 135
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320

                          90       100
                  ....*....|....*....|....
gi 568918516  136 FGNLRSTFMALMIGSYASSAITFP 159
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 55-191 2.15e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 40.66  E-value: 2.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918516  55 GFTIGSFLLSA--TTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASrdtevlSPLIFLALSL-NGFA-GICLTFTSL 130
Cdd:cd17489   34 GLVVGLFTLAAllARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT------SVALLLVLRLiHGIGwGAFTTAAAT 107

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568918516 131 TLPNMFGN-LRSTFMALM-IGSYASSAItFPGIKLIYDAGVPFTVIMFTWSGLACLIFLNCAL 191
Cdd:cd17489  108 LVADIIPPsRRGEGIGYYgLATTLAMAL-GPALGLFLYQHLGFAVLFIVAAVLALLALLLVFL 169
2A0108 TIGR00886
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
 68-190 4.19e-03

nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]


Pssm-ID: 273322 [Multi-domain]  Cd Length: 354  Bit Score: 39.59  E-value: 4.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918516   68 LPLGILMDRFGPRPLRLVGSACFAASCTLMALASRDTEVLSPLIFLAlslnGFAG----ICLTFTSLTLPNM-------- 135
Cdd:TIGR00886  55 IILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVQSYSVLLLIRLFI----GIAGgsfaSCMPWISFFFPKKiqgtalgl 130

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568918516  136 ---FGNLRSTFMALMIGSYASSAITFPGIKLIYDAGVPFTVIMFTWSGL-ACLIFLNCA 190
Cdd:TIGR00886 131 aagWGNMGGGVAQFVMPPIIGSLIFGGGQPAHLAWGWAFVIVPAGILLLpALLIFFVGA 189
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
51-187 7.25e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.12  E-value: 7.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918516  51 MLNLGFTIGSFLlsaTTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASRDTevlsplIFLALSLNGFAGICLTFTSL 130
Cdd:COG2211  268 LLLALYFLAALL---GAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGN------LWLLLVLAALAGIGLGAILV 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918516 131 TLPNMFGNL------------RSTFMALM-----IGSYASSAITFPGIKLI-YDAGVPFTV-----IMFTWSGLACLIFL 187
Cdd:COG2211  339 LPWAMLADVvdydewktgrrrEGLYFGIFtfaikLGQALAGALAGLLLALFgYVAGAAQSPsaltgIRLLFFLLPAVLLL 418
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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