Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 568921773    596 RIIIQERISRPRGIAVHPRARRLFWTDVGMsPRIESASLQGSDR 639
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568921773    553 ERLITEGVDTLEGLALDWIGRRIYWTDSGKSVVGGSDLSGKHH 595
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 568921773   445 CSSpDNGGCSQICLPlRPGSWECDCFPGYDLQSDRKSC 482
Cdd:pfam14670    1 CSV-NNGGCSHLCLN-TPGGYTCSCPEGYELQDDGRTC 36

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|...
gi 568921773   877 DIDECVLARSDCPSTSSrCINTEGGYVCRCSEG 909
Cdd:pfam07645    1 DVDECATGTHNCPANTV-CVNTIGSFECRCPDG 32

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568921773    158 RVLLSSLKHPSNIAVDPIERLMFWSSEVTGSLHRAHLKGVDV 199
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30
                    ....*....|....*....|....*....|..
gi 568921773    125 VSGLAIDWIDDEVLWVDQQNGVITVTDMTGKN 156
Cdd:smart00135   11 PNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 568921773    683 RRLIQNDVGHPFSLAV--FEDHLWVSDWAIPsVIRVNKRTGQNR 724
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLD-VIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 568921773    596 RIIIQERISRPRGIAVHPRARRLFWTDVGMsPRIESASLQGSDR 639
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568921773   616 RRLFWTDVGMSPRIESASLQGSDRVLIASSNLLEPSGITIDY 657
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568921773   366 CATQNHGCTLGCENTPGSYHCTCPTGFVLLPDGKQC 401
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568921773  358 KYCEDVNECATQNHGCTLGCENTPGSYHCTCPTGFVLLPDGK 399
Cdd:cd01475   182 KICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNK 223

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|...
gi 568921773   877 DIDECVLARSDCPSTSSrCINTEGGYVCRCSEG 909
Cdd:pfam07645    1 DVDECATGTHNCPANTV-CVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568921773    362 DVNECATqNHGCTLG--CENTPGSYHCTCPTGFVllpDGKQC 401
Cdd:smart00179    1 DIDECAS-GNPCQNGgtCVNTVGSYRCECPPGYT---DGRNC 38

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568921773   660 DTLYWCDTK-RSVIEMANLDGSKRRRLIQNDVGHPFSLAVFE 700
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568921773    158 RVLLSSLKHPSNIAVDPIERLMFWSSEVTGSLHRAHLKGVDV 199
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

EGF-like protein; Provisional

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568921773  941 CPSSYDGYCLNGgVCMHIESLDSYTCNCVIGYSGDRCQ 978
Cdd:PHA02887   86 CKNDFNDFCING-ECMNIIDLDEKFCICNKGYTGIRCD 122

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20
                   ....*....|....*....|....*....
gi 568921773   414 CSHGCVLTSDGPRCICPAGSVLGRDGKTC 442
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|
gi 568921773  949 CLNGGVCmhIESLDSYTCNCVIGYSGDRCQ 978
Cdd:cd00054    11 CQNGGTC--VNTVGSYRCSCPPGYTGRNCE 38

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20
                    ....*....|....*....|....*....
gi 568921773     86 MDIHYKKERLYWVDVERQVLLRVFLNGTG 114
Cdd:smart00135   14 LAVDWIEGRLYWTDWGLDVIEVANLDGTN 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 568921773    596 RIIIQERISRPRGIAVHPRARRLFWTDVGMsPRIESASLQGSDR 639
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568921773   616 RRLFWTDVGMSPRIESASLQGSDRVLIASSNLLEPSGITIDY 657
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568921773   366 CATQNHGCTLGCENTPGSYHCTCPTGFVLLPDGKQC 401
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568921773  358 KYCEDVNECATQNHGCTLGCENTPGSYHCTCPTGFVLLPDGK 399
Cdd:cd01475   182 KICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNK 223

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|...
gi 568921773   877 DIDECVLARSDCPSTSSrCINTEGGYVCRCSEG 909
Cdd:pfam07645    1 DVDECATGTHNCPANTV-CVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568921773    362 DVNECATqNHGCTLG--CENTPGSYHCTCPTGFVllpDGKQC 401
Cdd:smart00179    1 DIDECAS-GNPCQNGgtCVNTVGSYRCECPPGYT---DGRNC 38

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568921773   660 DTLYWCDTK-RSVIEMANLDGSKRRRLIQNDVGHPFSLAVFE 700
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568921773  362 DVNECATqNHGCTLG--CENTPGSYHCTCPTGFVllpdGKQC 401
Cdd:cd00054     1 DIDECAS-GNPCQNGgtCVNTVGSYRCSCPPGYT----GRNC 37

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 568921773   366 CATQNHGCTLG--CENTPGSYHCTCPTGFVLlpDGKQC 401
Cdd:pfam12947    1 CSDNNGGCHPNatCTNTGGSFTCTCNDGYTG--DGVTC 36

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 568921773  877 DIDECVLaRSDCPStSSRCINTEGGYVCRCSEGYEGD 913
Cdd:cd00054     1 DIDECAS-GNPCQN-GGTCVNTVGSYRCSCPPGYTGR 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30
                    ....*....|....*....|....*....|..
gi 568921773    125 VSGLAIDWIDDEVLWVDQQNGVITVTDMTGKN 156
Cdd:smart00135   11 PNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20
                   ....*....|....*....|....*....
gi 568921773   414 CSHGCVLTSDGPRCICPAGSVLGRDGKTC 442
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568921773   94 RLYWVDVERQVLLRVFLNGTGLEKVCNVERKVSGLAIDwiDDEVLWVDQQNGVITVTDMTGKNSRVLLSSLKHPSN---- 169
Cdd:COG3386    20 RLYWVDIPGGRIHRYDPDGGAVEVFAEPSGRPNGLAFD--PDGRLLVADHGRGLVRFDPADGEVTVLADEYGKPLNrpnd 97

                  ....*
gi 568921773  170 IAVDP 174
Cdd:COG3386    98 GVVDP 102

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|
gi 568921773  949 CLNGGVCmhIESLDSYTCNCVIGYSGDRCQ 978
Cdd:cd00054    11 CQNGGTC--VNTVGSYRCSCPPGYTGRNCE 38

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.

                          10        20        30
                  ....*....|....*....|....*....|..
gi 568921773  365 ECATqNHGCTLG--CENTPGSYHCTCPTGFVL 394
Cdd:cd00053     1 ECAA-SNPCSNGgtCVNTPGSYRCVCPPGYTG 31