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Conserved domains on  [gi|568922714|ref|XP_006501505|]
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carbonic anhydrase 14 isoform X1 [Mus musculus]

Protein Classification

carbonic anhydrase family protein( domain architecture ID 10123249)

carbonic anhydrase family protein similar to carbonic anhydrase, which catalyzes the reversible hydration of gaseous carbon dioxide to carbonic acid

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
alpha_CA_XII_XIV cd03126
Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing ...
29-278 4.51e-176

Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane proteins CA XII and XIV.


:

Pssm-ID: 239400  Cd Length: 249  Bit Score: 492.82  E-value: 4.51e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714  29 GQDHWPTSYPECGGDAQSPINIQTDSVIFDPDLPAVQPHGYDQLGTEPLDLHNNGHTVQLSLPPTLHLGGLPRKYTAAQL 108
Cdd:cd03126    1 GENSWPKKYPFCGGVAQSPIDIHTDILQYDSSLPPLEFHGYNVSGTEQFTLTNNGHTVQLSLPPTMHIGGLPFKYTASQL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714 109 HLHWGQRGSLEGSEHQINSEATAAELHVVHYDSQSYSSLSEAAQKPQGLAVLGILIEVGEtENPAYDHILSRLHEIRYKD 188
Cdd:cd03126   81 HLHWGQRGSPEGSEHTISGKHFAAELHIVHYNSDKYPDISTAMNKSQGLAVLGILIEVGP-FNPSYEKIFSHLHEVKYKD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714 189 QKTSVPPFSVRELFPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEDPSEPLVQNYRVPQP 268
Cdd:cd03126  160 QKVSVPGFNVQELLPKRLDEYYRYEGSLTTPPCYPSVLWTVFRNPVQISQEQLLALETALYSTEEDESREMVNNYRQVQP 239
                        250
                 ....*....|
gi 568922714 269 LNQRTIFASF 278
Cdd:cd03126  240 FNERLVFASF 249
 
Name Accession Description Interval E-value
alpha_CA_XII_XIV cd03126
Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing ...
29-278 4.51e-176

Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane proteins CA XII and XIV.


Pssm-ID: 239400  Cd Length: 249  Bit Score: 492.82  E-value: 4.51e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714  29 GQDHWPTSYPECGGDAQSPINIQTDSVIFDPDLPAVQPHGYDQLGTEPLDLHNNGHTVQLSLPPTLHLGGLPRKYTAAQL 108
Cdd:cd03126    1 GENSWPKKYPFCGGVAQSPIDIHTDILQYDSSLPPLEFHGYNVSGTEQFTLTNNGHTVQLSLPPTMHIGGLPFKYTASQL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714 109 HLHWGQRGSLEGSEHQINSEATAAELHVVHYDSQSYSSLSEAAQKPQGLAVLGILIEVGEtENPAYDHILSRLHEIRYKD 188
Cdd:cd03126   81 HLHWGQRGSPEGSEHTISGKHFAAELHIVHYNSDKYPDISTAMNKSQGLAVLGILIEVGP-FNPSYEKIFSHLHEVKYKD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714 189 QKTSVPPFSVRELFPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEDPSEPLVQNYRVPQP 268
Cdd:cd03126  160 QKVSVPGFNVQELLPKRLDEYYRYEGSLTTPPCYPSVLWTVFRNPVQISQEQLLALETALYSTEEDESREMVNNYRQVQP 239
                        250
                 ....*....|
gi 568922714 269 LNQRTIFASF 278
Cdd:cd03126  240 FNERLVFASF 249
Carb_anhydrase pfam00194
Eukaryotic-type carbonic anhydrase;
28-278 4.45e-118

Eukaryotic-type carbonic anhydrase;


Pssm-ID: 459707 [Multi-domain]  Cd Length: 252  Bit Score: 345.79  E-value: 4.45e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714   28 HGQDHWPTSYPECGGDAQSPINIQTDSVIFDPDLPAVQPHGYDQLGTEPlDLHNNGHTVQLSL----PPTLHLGGLPRKY 103
Cdd:pfam00194   1 LGPEHWGKVYPSCGGKRQSPINIDTRKVRYDPSLPPLTFQGYDVPPGKN-TLTNNGHTVQVSLddgdPSTISGGPLATRY 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714  104 TAAQLHLHWGQRGSlEGSEHQINSEATAAELHVVHYDSQsYSSLSEAAQKPQGLAVLGILIEVGETENPAYDHILSRLHE 183
Cdd:pfam00194  80 RLVQFHFHWGSTDS-RGSEHTIDGKRYPAELHIVHYNSK-YKSFDEAAKHPDGLAVLGVFFEVGDENNPYLQPIVSALDN 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714  184 IRYKDQKTSVPPFSVRELFPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEDPSEPLVQNY 263
Cdd:pfam00194 158 IKYKGKSVLLPPFDLSDLLPEDLTSYYTYNGSLTTPPCSESVTWIVFKEPISISEEQLEAFRTLLFSDGGEEPRPLVNNF 237
                         250
                  ....*....|....*
gi 568922714  264 RVPQPLNQRTIFASF 278
Cdd:pfam00194 238 RPTQPLNGRVVFASF 252
Carb_anhydrase smart01057
Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse ...
22-273 2.89e-103

Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse the reversible hydration of carbon dioxide to bicarbonate.. CAs have essential roles in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space; they are also involved in many other processes, from respiration and photosynthesis in eukaryotes to cyanate degradation in prokaryotes. There are five known evolutionarily distinct CA families (alpha, beta, gamma, delta and epsilon) that have no significant sequence identity and have structurally distinct overall folds. Some CAs are membrane-bound, while others act in the cytosol; there are several related proteins that lack enzymatic activity. The active site of alpha-CAs is well described, consisting of a zinc ion coordinated through 3 histidine residues and a water molecule/hydroxide ion that acts as a potent nucleophile. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site. Beta- and gamma-CAs also employ a zinc hydroxide mechanism, although at least some beta-class enzymes do not have water directly coordinated to the metal ion.


Pssm-ID: 215000 [Multi-domain]  Cd Length: 247  Bit Score: 307.70  E-value: 2.89e-103
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714    22 WTYEGPHGQDHWPTSYPE-CGGDAQSPINIQTDSVIFDPDLPAVQPHgYDQLGtePLDLHNNGHTVQLSLP---PTLHLG 97
Cdd:smart01057   1 WGYEGKNGPEHWGKLDPPfCGGKRQSPIDIVTAEAQYDPSLKPLKLS-YDQPT--AKRILNNGHTVQVNFDddgSTLSGG 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714    98 GLPRKYTAAQLHLHWGQRGSlEGSEHQINSEATAAELHVVHYDSQSysSLSEAAQKPQGLAVLGILIEVGETENPAYDHI 177
Cdd:smart01057  78 PLPGRYRLKQFHFHWGGSDS-EGSEHTIDGKRFPLELHLVHYNSKG--SFSEAVSKPGGLAVVAVFFKVGAEENPALQAI 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714   178 LSRLHEIRYKDQKTSVPPFSVRELFPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEdpsE 257
Cdd:smart01057 155 LDHLPLIKYKGQETELTPFDLSSLLPASTRHYYTYNGSLTTPPCSEGVTWIVFKEPITISTEQLEKFRTLLPMEGN---E 231
                          250
                   ....*....|....*.
gi 568922714   258 PLVQNYRVPQPLNQRT 273
Cdd:smart01057 232 PLVNNARPLQPLNGRV 247
Cah COG3338
Carbonic anhydrase [Inorganic ion transport and metabolism];
2-277 2.23e-56

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 442567 [Multi-domain]  Cd Length: 247  Bit Score: 187.01  E-value: 2.23e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714   2 LFFALLLKVTWILAADGGHHWTYEGPHGQDHWPT---SYPECG-GDAQSPINIqTDSVifDPDLPAVQPHgYdqlGTEPL 77
Cdd:COG3338    8 ALLLAAALPAAAAAAASAPHWSYEGETGPEHWGElspEFATCAtGKNQSPIDI-RTAI--KADLPPLKFD-Y---KPTPL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714  78 DLHNNGHTVQLSLPP--TLHLGGlpRKYTAAQLHLHwgqrgslEGSEHQINSEATAAELHVVHYDsqsysslseaaqkPQ 155
Cdd:COG3338   81 EIVNNGHTIQVNVDPgsTLTVDG--KRYELKQFHFH-------TPSEHTINGKSYPMEAHLVHKD-------------AD 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714 156 G-LAVLGILIEVGEtENPAYDHILSRLHEIRyKDQKTSVPPFSVRELFPQQLEqFFRYNGSLTTPPCYQSVLWTVFNRRA 234
Cdd:COG3338  139 GeLAVVGVLFEEGA-ENPALAKLWANLPLEA-GEEVALDATIDLNDLLPEDRS-YYRYSGSLTTPPCSEGVLWIVLKQPI 215
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 568922714 235 QISMGQLEKLQETLSSteedpseplvqNYRVPQPLNQRTIFAS 277
Cdd:COG3338  216 TVSAEQIEAFARLYPN-----------NARPVQPLNGRLILES 247
PLN02202 PLN02202
carbonate dehydratase
1-274 1.93e-16

carbonate dehydratase


Pssm-ID: 177853 [Multi-domain]  Cd Length: 284  Bit Score: 79.33  E-value: 1.93e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714   1 MLFFAL-LLKVTWILAADGGHHWTYEGPHGQDHWPTSYP---ECG-GDAQSPINIQTDSVIFDPDLPAVQPHGYDQLGTe 75
Cdd:PLN02202   9 LCFFAIaLICIAPADAQTEGVVFGYKGKNGPNQWGHLNPhftKCAvGKLQSPIDIQRRQIFYNHKLESIHRDYYFTNAT- 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714  76 pldLHNngHTVQLSLPPTLHLGGL---PRKYTAAQLHLHwgqrgslEGSEHQINSEATAAELHVVHydsqsysslseaAQ 152
Cdd:PLN02202  88 ---LVN--HVCNVAMFFGEGAGDViidNKNYTLLQMHWH-------TPSEHHLHGVQYAAELHMVH------------QA 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714 153 KPQGLAVLGILIEVGeTENPAYDHI---LSRLHEIRYKDQKTS---VPPFSVRELfPQQLEQFFRYNGSLTTPPCYQSVL 226
Cdd:PLN02202 144 KDGSFAVVASLFKIG-TEEPFLSQMkdkLVKLKEERFKGNHTAqveVGKIDTRHI-ERKTRKYFRYIGSLTTPPCSENVS 221
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 568922714 227 WTVFNRRAQISMGQLEKLQETLSSTEEDPSEPLvqnyrvpQPLNQRTI 274
Cdd:PLN02202 222 WTILGKVRSMSKEQVELLRSPLDKSFKNNSRPC-------QPLNGRRV 262
 
Name Accession Description Interval E-value
alpha_CA_XII_XIV cd03126
Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing ...
29-278 4.51e-176

Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane proteins CA XII and XIV.


Pssm-ID: 239400  Cd Length: 249  Bit Score: 492.82  E-value: 4.51e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714  29 GQDHWPTSYPECGGDAQSPINIQTDSVIFDPDLPAVQPHGYDQLGTEPLDLHNNGHTVQLSLPPTLHLGGLPRKYTAAQL 108
Cdd:cd03126    1 GENSWPKKYPFCGGVAQSPIDIHTDILQYDSSLPPLEFHGYNVSGTEQFTLTNNGHTVQLSLPPTMHIGGLPFKYTASQL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714 109 HLHWGQRGSLEGSEHQINSEATAAELHVVHYDSQSYSSLSEAAQKPQGLAVLGILIEVGEtENPAYDHILSRLHEIRYKD 188
Cdd:cd03126   81 HLHWGQRGSPEGSEHTISGKHFAAELHIVHYNSDKYPDISTAMNKSQGLAVLGILIEVGP-FNPSYEKIFSHLHEVKYKD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714 189 QKTSVPPFSVRELFPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEDPSEPLVQNYRVPQP 268
Cdd:cd03126  160 QKVSVPGFNVQELLPKRLDEYYRYEGSLTTPPCYPSVLWTVFRNPVQISQEQLLALETALYSTEEDESREMVNNYRQVQP 239
                        250
                 ....*....|
gi 568922714 269 LNQRTIFASF 278
Cdd:cd03126  240 FNERLVFASF 249
alpha_CA_VI_IX_XII_XIV cd03123
Carbonic anhydrase alpha, isozymes VI, IX, XII and XIV. Carbonic anhydrases (CAs) are ...
29-278 6.43e-158

Carbonic anhydrase alpha, isozymes VI, IX, XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Alpha CAs are mostly monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the secreted CA VI, which is found in saliva, for example, and the membrane proteins CA IX, XII, and XIV.


Pssm-ID: 239397 [Multi-domain]  Cd Length: 248  Bit Score: 446.75  E-value: 6.43e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714  29 GQDHWPTSYPECGGDAQSPINIQTDSVIFDPDLPAVQPHGYDQLGTEPLDLHNNGHTVQLSLPPTLHLGGLP-RKYTAAQ 107
Cdd:cd03123    1 GEDHWPKKYPACGGKRQSPIDIQTDIVQFDPSLPPLELVGYDLPGTEEFTLTNNGHTVQLSLPPTMHIRGGPgTEYTAAQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714 108 LHLHWGQRGSLEGSEHQINSEATAAELHVVHYDSQSYSSLSEAAQKPQGLAVLGILIEVGETENPAYDHILSRLHEIRYK 187
Cdd:cd03123   81 LHLHWGGRGSLSGSEHTIDGIRFAAELHIVHYNSDKYSSFDEAADKPDGLAVLAILIEVGYPENTYYEKIISHLHEIKYK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714 188 DQKTSVPPFSVRELFPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEedpSEPLVQNYRVPQ 267
Cdd:cd03123  161 GQETTVPGFNVRELLPEDLSHYYRYEGSLTTPPCYESVLWTVFRDPVTLSKEQLETLENTLMDTH---NKTLQNNYRATQ 237
                        250
                 ....*....|.
gi 568922714 268 PLNQRTIFASF 278
Cdd:cd03123  238 PLNGRVVEASF 248
Carb_anhydrase pfam00194
Eukaryotic-type carbonic anhydrase;
28-278 4.45e-118

Eukaryotic-type carbonic anhydrase;


Pssm-ID: 459707 [Multi-domain]  Cd Length: 252  Bit Score: 345.79  E-value: 4.45e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714   28 HGQDHWPTSYPECGGDAQSPINIQTDSVIFDPDLPAVQPHGYDQLGTEPlDLHNNGHTVQLSL----PPTLHLGGLPRKY 103
Cdd:pfam00194   1 LGPEHWGKVYPSCGGKRQSPINIDTRKVRYDPSLPPLTFQGYDVPPGKN-TLTNNGHTVQVSLddgdPSTISGGPLATRY 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714  104 TAAQLHLHWGQRGSlEGSEHQINSEATAAELHVVHYDSQsYSSLSEAAQKPQGLAVLGILIEVGETENPAYDHILSRLHE 183
Cdd:pfam00194  80 RLVQFHFHWGSTDS-RGSEHTIDGKRYPAELHIVHYNSK-YKSFDEAAKHPDGLAVLGVFFEVGDENNPYLQPIVSALDN 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714  184 IRYKDQKTSVPPFSVRELFPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEDPSEPLVQNY 263
Cdd:pfam00194 158 IKYKGKSVLLPPFDLSDLLPEDLTSYYTYNGSLTTPPCSESVTWIVFKEPISISEEQLEAFRTLLFSDGGEEPRPLVNNF 237
                         250
                  ....*....|....*
gi 568922714  264 RVPQPLNQRTIFASF 278
Cdd:pfam00194 238 RPTQPLNGRVVFASF 252
Carb_anhydrase smart01057
Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse ...
22-273 2.89e-103

Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse the reversible hydration of carbon dioxide to bicarbonate.. CAs have essential roles in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space; they are also involved in many other processes, from respiration and photosynthesis in eukaryotes to cyanate degradation in prokaryotes. There are five known evolutionarily distinct CA families (alpha, beta, gamma, delta and epsilon) that have no significant sequence identity and have structurally distinct overall folds. Some CAs are membrane-bound, while others act in the cytosol; there are several related proteins that lack enzymatic activity. The active site of alpha-CAs is well described, consisting of a zinc ion coordinated through 3 histidine residues and a water molecule/hydroxide ion that acts as a potent nucleophile. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site. Beta- and gamma-CAs also employ a zinc hydroxide mechanism, although at least some beta-class enzymes do not have water directly coordinated to the metal ion.


Pssm-ID: 215000 [Multi-domain]  Cd Length: 247  Bit Score: 307.70  E-value: 2.89e-103
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714    22 WTYEGPHGQDHWPTSYPE-CGGDAQSPINIQTDSVIFDPDLPAVQPHgYDQLGtePLDLHNNGHTVQLSLP---PTLHLG 97
Cdd:smart01057   1 WGYEGKNGPEHWGKLDPPfCGGKRQSPIDIVTAEAQYDPSLKPLKLS-YDQPT--AKRILNNGHTVQVNFDddgSTLSGG 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714    98 GLPRKYTAAQLHLHWGQRGSlEGSEHQINSEATAAELHVVHYDSQSysSLSEAAQKPQGLAVLGILIEVGETENPAYDHI 177
Cdd:smart01057  78 PLPGRYRLKQFHFHWGGSDS-EGSEHTIDGKRFPLELHLVHYNSKG--SFSEAVSKPGGLAVVAVFFKVGAEENPALQAI 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714   178 LSRLHEIRYKDQKTSVPPFSVRELFPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEdpsE 257
Cdd:smart01057 155 LDHLPLIKYKGQETELTPFDLSSLLPASTRHYYTYNGSLTTPPCSEGVTWIVFKEPITISTEQLEKFRTLLPMEGN---E 231
                          250
                   ....*....|....*.
gi 568922714   258 PLVQNYRVPQPLNQRT 273
Cdd:smart01057 232 PLVNNARPLQPLNGRV 247
alpha_CA cd00326
Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are ...
42-275 1.81e-97

Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues and a fourth conserved histidine plays a potential role in proton transfer.


Pssm-ID: 238200  Cd Length: 227  Bit Score: 292.26  E-value: 1.81e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714  42 GDAQSPINIQTDSVIFDPDLPAVQPHGYDqlgTEPLDLHNNGHTVQLSLP---PTLHLGGLPRKYTAAQLHLHWGQRGSl 118
Cdd:cd00326    1 GKRQSPINIVTSAVVYDPSLPPLNFDYYP---TTSLTLVNNGHTVQVNFDddgGTLSGGGLPGRYKLVQFHFHWGSENS- 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714 119 EGSEHQINSEATAAELHVVHYDSQSYSSlsEAAQKPQGLAVLGILIEVGETENPAYDHILSRLHEIRYKDQKTSVPPFSV 198
Cdd:cd00326   77 PGSEHTIDGKRYPLELHLVHYNSDYYSS--EAAKKPGGLAVLGVFFEVGEKENPFLKKILDALPKIKYKGKETTLPPFDL 154
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568922714 199 RELFPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTeedpSEPLVQNYRVPQPLNQRTIF 275
Cdd:cd00326  155 SDLLPSSLRDYYTYEGSLTTPPCSEGVTWIVFKEPITISKEQLEAFRSLLDRE----GKPLVNNYRPVQPLNGRVVY 227
alpha_CA_IV_XV_like cd03117
Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are ...
42-276 9.59e-92

Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This subgroup, restricted to animals, contains isozyme IV and similar proteins such as mouse CA XV. Isozymes IV is attached to membranes via a glycosylphosphatidylinositol (GPI) tail. In mammals, Isozyme IV plays crucial roles in kidney and lung function, amongst others. This subgroup also contains the dual domain CA from the giant clam, Tridacna gigas. T. gigas CA plays a role in the movement of inorganic carbon from the surrounding seawater to the symbiotic algae found in the clam's tissues. CA XV is expressed in several species but not in humans or chimps. Similar to isozyme CA IV, CA XV attaches to membranes via a GPI tail.


Pssm-ID: 239391  Cd Length: 234  Bit Score: 278.00  E-value: 9.59e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714  42 GDAQSPINIQTDSVIFDPDLPAVQPHGYDqLGTEPLDLHNNGHTVQLSLPPTLHL--GGLPRKYTAAQLHLHWGQRGSlE 119
Cdd:cd03117    1 GKRQSPINIVTKKVQYDENLTPFTFTGYD-DTTTNWTITNNGHTVQVTLPDGAKIsgGGLPGTYKALQFHFHWGSNGS-P 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714 120 GSEHQINSEATAAELHVVHYDSqSYSSLSEAAQKPQGLAVLGILIEVGETENPAYDHILSRLHEIRYKDQKTSVPPFSVR 199
Cdd:cd03117   79 GSEHTIDGERYPMELHIVHIKE-SYNSLLEALKDSDGLAVLGFFIEEGEEENTNFDPLISALSNIPQKGGSTNLTPFSLR 157
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568922714 200 ELFPQQ-LEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTeEDPSEPLVQNYRVPQPLNQRTIFA 276
Cdd:cd03117  158 SLLPSVlLTKYYRYNGSLTTPGCNEAVIWTVFEEPIPISRAQLDAFSTVLFFD-TDNGQPMVNNFRPVQPLNGRVVYA 234
alpha_CA_IX cd03150
Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes ...
29-278 6.15e-85

Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Alpha CAs are strictly monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane protein CA IX. CA IX is functionally implicated in tumor growth and survival. CA IX is mainly present in solid tumors and its expression in normal tissues is limited to the mucosa of alimentary tract. CA IX is a transmembrane protein with two extracellular domains: carbonic anhydrase and, a proteoglycan-like segment mediating cell-cell adhesion. There is evidence for an involvement of the MAPK pathway in the regulation of CA9 expression.


Pssm-ID: 239403  Cd Length: 247  Bit Score: 261.04  E-value: 6.15e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714  29 GQDHWPTSYPECGGDAQSPINIQTDSVIFDPDLPAVQPHGYDQLGTEPLDLHNNGHTVQLSLPPTLHLG-GLPRKYTAAQ 107
Cdd:cd03150    1 GQPPWPSVSPACAGRFQSPVDIRPHLVAFCPALRPLELLGFDLPPSPSLRLLNNGHTVQLSLPSGLRMAlGPGQEYRALQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714 108 LHLHWGQRGsLEGSEHQINSEATAAELHVVHYDSqSYSSLSEAAQKPQGLAVLGILIEVGETENPAYDHILSRLHEIRYK 187
Cdd:cd03150   81 LHLHWGAAG-RPGSEHTVDGHRFPAEIHVVHLST-AFANLDEALGRPGGLAVLAAFLAEGLHENSAYEQLLSRLSEISEE 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714 188 DQKTSVPPFSVRELFPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSteedPSEPLVQ-NYRVP 266
Cdd:cd03150  159 ESETVVPGLDVSALLPSDLSRYFRYEGSLTTPPCAQGVIWTVFNQTVRLSAKQLHTLSDSLWG----PHDSRLQlNFRAT 234
                        250
                 ....*....|..
gi 568922714 267 QPLNQRTIFASF 278
Cdd:cd03150  235 QPLNGRKIEASF 246
alpha_CA_VI cd03125
Carbonic anhydrase alpha, isozyme VI. Carbonic anhydrases (CAs) are zinc-containing enzymes ...
29-278 1.11e-80

Carbonic anhydrase alpha, isozyme VI. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the secreted CA VI, which is found in saliva.


Pssm-ID: 239399  Cd Length: 249  Bit Score: 250.09  E-value: 1.11e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714  29 GQDHWPTSYPECGGDAQSPINIQTDSVIFDPDLPAVQPHGYDQLGTEpLDLHNNGHTVQLSLPPTLHLG-GLPRKYTAAQ 107
Cdd:cd03125    1 DESHWPEKYPACGGKRQSPIDIQRREVRFNPSLLQLELVGYEKEQGE-FTMTNNGHTVQIDLPPTMSITtGDGTVYTAVQ 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714 108 LHLHWGQRGS-LEGSEHQINSEATAAELHVVHYDSQsYSSLSEAAQKPQGLAVLGILIEVGE-TENPAYDHILSRLHEIR 185
Cdd:cd03125   80 MHFHWGGRDSeISGSEHTIDGMRYVAELHIVHYNSK-YKSYEEAKDKPDGLAVLAFLYKVGHyAENTYYSDFISKLAKIK 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714 186 YKDQKTSVPPFSVRELFPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSsteeDPSEPLVQN-YR 264
Cdd:cd03125  159 YAGQTTTLTSLDVRDMLPENLHHYYTYQGSLTTPPCTENVLWFVFDDPVTLSKTQIVKLENTLM----DHHNKTIRNdYR 234
                        250
                 ....*....|....
gi 568922714 265 VPQPLNQRTIFASF 278
Cdd:cd03125  235 RTQPLNHRVVEANF 248
alpha_CA_I_II_III_XIII cd03119
Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are ...
20-278 4.09e-67

Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozymes I, II, and III, which are cytoplasmic enzymes. CA I, for example, is expressed in erythrocyes of many vertebrates; CA II is the most active cytosolic isozyme; while it is being expressed nearly ubiquitously, it comprises 95% of the renal carbonic anhydrase and is required for renal acidification; CA III has been implicated in protection from the damaging effect of oxidizing agents in hepatocytes. CAXIII may play important physiological roles in several organs.


Pssm-ID: 239393 [Multi-domain]  Cd Length: 259  Bit Score: 215.38  E-value: 4.09e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714  20 HHWTYEGPHGQDHWPTSYPECGGDAQSPINIQTDSVIFDPDLpavQPHGYDQLGTEPLDLHNNGHTVQLSLPPT-----L 94
Cdd:cd03119    3 HHWGYDSHNGPEHWHELFPIAKGDRQSPIDIKTKDAKHDPSL---KPLSVSYDPATAKTILNNGHSFNVEFDDTddrsvL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714  95 HLGGLPRKYTAAQLHLHWGQRGSlEGSEHQINSEATAAELHVVHYDSQsYSSLSEAAQKPQGLAVLGILIEVGEtENPAY 174
Cdd:cd03119   80 RGGPLTGSYRLRQFHFHWGSSDD-HGSEHTVDGVKYAAELHLVHWNSK-YGSFGEAAKQPDGLAVVGVFLKVGE-ANPEL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714 175 DHILSRLHEIRYKDQKTSVPPFSVRELFPQQLEqFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEED 254
Cdd:cd03119  157 QKVLDALDSIKTKGKQAPFTNFDPSCLLPASLD-YWTYPGSLTTPPLLECVTWIVLKEPISVSSEQMAKFRSLLFNAEGE 235
                        250       260
                 ....*....|....*....|....
gi 568922714 255 PSEPLVQNYRVPQPLNQRTIFASF 278
Cdd:cd03119  236 PPCPMVDNWRPPQPLKGRKVRASF 259
alpha_CA_VII cd03149
Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are ...
42-278 8.41e-59

Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozyme VII. CA VII is the most active cytosolic enzyme after CA II, and may be highly expressed in the brain. Human CA VII may be a target of antiepileptic sulfonamides/sulfamates.


Pssm-ID: 239402  Cd Length: 236  Bit Score: 193.13  E-value: 8.41e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714  42 GDAQSPINIQTDSVIFDPDLpavQPHGYDQLGTEPLDLHNNGHTVQLSLPPT-----LHLGGLPRKYTAAQLHLHWGQRG 116
Cdd:cd03149    1 GNRQSPIDIVSSEAVYDPKL---KPLSLSYDPCTSLSISNNGHSVMVEFDDSddktvITGGPLENPYRLKQFHFHWGAKH 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714 117 SlEGSEHQINSEATAAELHVVHYDSQSYSSLSEAAQKPQGLAVLGILIEVGEtENPAYDHILSRLHEIRYKDQKTSVPPF 196
Cdd:cd03149   78 G-SGSEHTVDGKTFPSELHLVHWNAKKYKSFGEAAAAPDGLAVLGVFLETGD-EHPGLNRLTDALYMVRFKGTKAQFLDF 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714 197 SVRELFPQQLEqFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEDPSEPLVQNYRVPQPLNQRTIFA 276
Cdd:cd03149  156 NPKCLLPKSLD-YWTYPGSLTTPPLNESVTWIVLKEPIPVSEKQMGKFRELLFTSEEDQRNHMVNNFRPPQPLKGRTVRA 234

                 ..
gi 568922714 277 SF 278
Cdd:cd03149  235 SF 236
Cah COG3338
Carbonic anhydrase [Inorganic ion transport and metabolism];
2-277 2.23e-56

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 442567 [Multi-domain]  Cd Length: 247  Bit Score: 187.01  E-value: 2.23e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714   2 LFFALLLKVTWILAADGGHHWTYEGPHGQDHWPT---SYPECG-GDAQSPINIqTDSVifDPDLPAVQPHgYdqlGTEPL 77
Cdd:COG3338    8 ALLLAAALPAAAAAAASAPHWSYEGETGPEHWGElspEFATCAtGKNQSPIDI-RTAI--KADLPPLKFD-Y---KPTPL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714  78 DLHNNGHTVQLSLPP--TLHLGGlpRKYTAAQLHLHwgqrgslEGSEHQINSEATAAELHVVHYDsqsysslseaaqkPQ 155
Cdd:COG3338   81 EIVNNGHTIQVNVDPgsTLTVDG--KRYELKQFHFH-------TPSEHTINGKSYPMEAHLVHKD-------------AD 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714 156 G-LAVLGILIEVGEtENPAYDHILSRLHEIRyKDQKTSVPPFSVRELFPQQLEqFFRYNGSLTTPPCYQSVLWTVFNRRA 234
Cdd:COG3338  139 GeLAVVGVLFEEGA-ENPALAKLWANLPLEA-GEEVALDATIDLNDLLPEDRS-YYRYSGSLTTPPCSEGVLWIVLKQPI 215
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 568922714 235 QISMGQLEKLQETLSSteedpseplvqNYRVPQPLNQRTIFAS 277
Cdd:COG3338  216 TVSAEQIEAFARLYPN-----------NARPVQPLNGRLILES 247
alpha_CARP_receptor_like cd03122
Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related ...
29-276 9.37e-56

Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. This sub-family of carbonic anhydrase-related domains found in tyrosine phosphatase receptors may play a role in cell adhesion.


Pssm-ID: 239396 [Multi-domain]  Cd Length: 253  Bit Score: 185.64  E-value: 9.37e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714  29 GQDHWPTSYPECGGDA-QSPINIQTDSVIfdpDLPAVQPHGYDQLGTEPLD--LHNNGHTVQLSLP-----PTLHLGGLP 100
Cdd:cd03122    1 NPKHWAKKYPACGEGRqQSPIDIVEDTQV---QRQGLQPLHFDGYEELTASttLENTGKTVILRLEgnssdPFVSGGPLL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714 101 RKYTAAQLHLHWGQRGSLeGSEHQINSEATAAELHVVHYDSQSYSSLsEAAQKPQGLAVLGILIEVGETENPAYDHILSR 180
Cdd:cd03122   78 GRYKFSEITFHWGTCNSD-GSEHSIDGHKFPLEMQILHRNTDFFDSF-EAIKSPGGVLALAYLFELSHEDNPFLDPIIEG 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714 181 LHEIRYKDQKTSVPPFSVRELFPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQEtLSSTEEDPS---E 257
Cdd:cd03122  156 LRNVSRPGKEVELPPFPLSDLLPPFTDKYYSYEGSLTTPPCSETVEWIVFREPVPISSRQLEAFRE-LLTRRQDGVmsgD 234
                        250
                 ....*....|....*....
gi 568922714 258 PLVQNYRVPQPLNQRTIFA 276
Cdd:cd03122  235 YLPNNGRPQQPLGSRTVFS 253
alpha_CA_prokaryotic_like cd03124
Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are ...
29-274 1.93e-51

Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This sub-family includes bacterial carbonic anhydrase alpha, as well as plant enzymes such as tobacco nectarin III and yam dioscorin and, carbonic anhydrases from molluscs, such as nacrein, which are part of the organic matrix layer in shells. Other members of this family may be involved in maintaining pH balance, in facilitating transport of carbon dioxide or carbonic acid, or in sensing carbon dioxide levels in the environment. Dioscorin is the major storage protein of yam tubers and may play a role as an antioxidant. Tobacco Nectarin may play a role in the maintenace of pH and oxidative balance in nectar. Mollusc nacrein may participate in calcium carbonate crystal formation of the nacreous layer. This subfamily also includes three alpha carbonic anhydrases from Chlamydomonas reinhardtii (CAH 1-3). CAHs1-2 are localized in the periplasmic space. CAH1 faciliates the movement of carbon dioxide across the plasma membrane when the medium is alkaline. CAH3 is localized to the thylakoid lumen and provides CO2 to Rubisco.


Pssm-ID: 239398 [Multi-domain]  Cd Length: 216  Bit Score: 173.23  E-value: 1.93e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714  29 GQDHWPTSYPE---CG-GDAQSPINIQTDSVIFDPDLP-AVQPHgydqlgTEPLDLHNNGHTVQLSLPP---TLHLGGlp 100
Cdd:cd03124    1 GPEHWGNLDPEfalCAtGKNQSPIDITTKAVVSDKLPPlNYNYK------PTSATLVNNGHTIQVNFEGnggTLTIDG-- 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714 101 RKYTAAQLHLHwgqrgslEGSEHQINSEATAAELHVVHYDsqsysslseaaqKPQGLAVLGILIEVGEtENPAYDHILSR 180
Cdd:cd03124   73 ETYQLLQFHFH-------SPSEHLINGKRYPLEAHLVHKS------------KDGQLAVVAVLFEEGK-ENPFLKKILDN 132
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714 181 LHEIryKDQKTSVPPFS-VRELFPQQLEqFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTeedpsepl 259
Cdd:cd03124  133 MPKK--EGTEVNLPAILdPNELLPESRS-YYRYEGSLTTPPCSEGVRWIVLKQPITISKEQLAKFRAAVYPN-------- 201
                        250
                 ....*....|....*
gi 568922714 260 vqNYRVPQPLNQRTI 274
Cdd:cd03124  202 --NARPVQPLNGREV 214
alpha_CARP_X_XI_like cd03121
Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup ...
42-274 2.40e-50

Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. CARP XI plays a role in the development of gastrointestinal stromal tumors.


Pssm-ID: 239395 [Multi-domain]  Cd Length: 256  Bit Score: 171.83  E-value: 2.40e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714  42 GDAQSPINIQTDSVIFDPDLPAVQPHGYDQLGTEpldLHNNGHTVQLSLPPTLHL----GGLPRKYTAAQLHLHWGQRGS 117
Cdd:cd03121   18 GRRQSPVDIEPSRLLFDPFLTPLRIDTGRKVSGT---FYNTGRHVSFRPDKDPVVnisgGPLSYRYRLEEIRLHFGREDE 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714 118 lEGSEHQINSEATAAELHVVHYDSQSYSSLSEAAQKPQGLAVLGILIEVGETENPAYDHILSRL--HEIRYKDQKTSVPP 195
Cdd:cd03121   95 -QGSEHTVNGQAFPGEVQLIHYNSELYPNFSEASKSPNGLVIVSLFVKIGETSNPELRRLTNRDtiTSIRYKGDAYFLQD 173
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568922714 196 FSVRELFPQQlEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEDPSEPLVQNYRVPQPLNQRTI 274
Cdd:cd03121  174 LSIELLLPET-DHYITYEGSLTSPGCHETVTWIILNKPIYITKEQMHSLRLLSQNSPSQEKAPMSPNFRPVQPLNNRPV 251
alpha_CA_V cd03118
Carbonic anhydrase alpha, CA isozyme V_like subgroup. Carbonic anhydrases (CAs) are ...
42-278 1.45e-43

Carbonic anhydrase alpha, CA isozyme V_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozyme V. CA V is the mitochondrial isozyme, which may play a role in gluconeogenesis and ureagenesis and possibly also in lipogenesis.


Pssm-ID: 239392  Cd Length: 236  Bit Score: 153.08  E-value: 1.45e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714  42 GDAQSPINIQTDSVIFDPDLPAVQPHgYDqlGTEPLDLHNNGHTVQLSL-----PPTLHLGGLPRKYTAAQLHLHWGQRG 116
Cdd:cd03118    1 GTRQSPINIQWRDSVYDPQLAPLRVS-YD--PATCLYIWNNGYSFQVEFddstdKSGISGGPLENHYRLKQFHFHWGANN 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714 117 SLeGSEHQINSEATAAELHVVHYDSQSYSSLSEAAQKPQGLAVLGILIEVGEtENPAYDHILSRLHEIRYKDQKTSVPPF 196
Cdd:cd03118   78 EW-GSEHTVDGHTYPAELHLVHWNSVKYENFEEAVMEENGLAVIGVFLKLGA-HHEGLQKLVDALPEVRHKDTVVEFNPF 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714 197 SVRELFPQQLEqFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEDPSEPLVQNYRVPQPLNQRTIFA 276
Cdd:cd03118  156 DPSCLLPACRD-YWTYPGSLTTPPLTESVTWIIQKQPIEVSPSQLSVFRTLLFTSRGEEEKVMVNNFRPLQPLMNRKVRS 234

                 ..
gi 568922714 277 SF 278
Cdd:cd03118  235 SF 236
alpha_CARP_VIII cd03120
Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins ...
33-278 1.90e-43

Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. CARP VIII may play roles in various biological processes of the central nervous system, and could be involved in protein-protein interactions. CARP VIII has been shown to bind inositol 1,4,5-triphosphate (IP3) receptor type I (IP3RI), reducing the affinity of the receptor for IP3. IP3RI is an intracellular IP3-gated Ca2+ channel located on intracellular Ca2+ stores. IP3RI converts IP3 signaling into Ca2+ signaling thereby participating in a variety of cell functions.


Pssm-ID: 239394  Cd Length: 256  Bit Score: 153.47  E-value: 1.90e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714  33 WPTSYPECGGDAQSPINIQTDSVIFDPDLPAVqPHGYDQLGTEPLDLHNNGHTVQLSLP--PTLHLGGLPR--KYTAAQL 108
Cdd:cd03120    4 WGLLFPEANGEYQSPINLNSREARYDPSLLEV-RLSPNYVVCRDCEVINDGHTIQIILKskSVLSGGPLPQghEFELAEV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714 109 HLHWGQRGSlEGSEHQINSEATAAELHVVHYDSQSYSSLSEAAQKPQGLAVLGILIEVGEtENPAYDHILSRLHEIRYKD 188
Cdd:cd03120   83 RFHWGRENQ-RGSEHTVNFKAFPMELHLIHWNSTLYSSLEEAMGKPHGIAIIALFVQIGK-EHVGLKAVTEILQDIQYKG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714 189 QKTSVPPFSVRELFPQ-QLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEDPSEP-----LVQN 262
Cdd:cd03120  161 KSKTIPCFNPNTLLPDpLLRDYWVYEGSLTTPPCSEGVTWILFRYPLTISQSQIEEFRRLRTHVKGAELVEgcdglLGDN 240
                        250
                 ....*....|....*.
gi 568922714 263 YRVPQPLNQRTIFASF 278
Cdd:cd03120  241 FRPTQPLSDRVIRAAF 256
PLN02202 PLN02202
carbonate dehydratase
1-274 1.93e-16

carbonate dehydratase


Pssm-ID: 177853 [Multi-domain]  Cd Length: 284  Bit Score: 79.33  E-value: 1.93e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714   1 MLFFAL-LLKVTWILAADGGHHWTYEGPHGQDHWPTSYP---ECG-GDAQSPINIQTDSVIFDPDLPAVQPHGYDQLGTe 75
Cdd:PLN02202   9 LCFFAIaLICIAPADAQTEGVVFGYKGKNGPNQWGHLNPhftKCAvGKLQSPIDIQRRQIFYNHKLESIHRDYYFTNAT- 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714  76 pldLHNngHTVQLSLPPTLHLGGL---PRKYTAAQLHLHwgqrgslEGSEHQINSEATAAELHVVHydsqsysslseaAQ 152
Cdd:PLN02202  88 ---LVN--HVCNVAMFFGEGAGDViidNKNYTLLQMHWH-------TPSEHHLHGVQYAAELHMVH------------QA 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714 153 KPQGLAVLGILIEVGeTENPAYDHI---LSRLHEIRYKDQKTS---VPPFSVRELfPQQLEQFFRYNGSLTTPPCYQSVL 226
Cdd:PLN02202 144 KDGSFAVVASLFKIG-TEEPFLSQMkdkLVKLKEERFKGNHTAqveVGKIDTRHI-ERKTRKYFRYIGSLTTPPCSENVS 221
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 568922714 227 WTVFNRRAQISMGQLEKLQETLSSTEEDPSEPLvqnyrvpQPLNQRTI 274
Cdd:PLN02202 222 WTILGKVRSMSKEQVELLRSPLDKSFKNNSRPC-------QPLNGRRV 262
PLN02179 PLN02179
carbonic anhydrase
23-232 2.71e-11

carbonic anhydrase


Pssm-ID: 177835  Cd Length: 235  Bit Score: 63.46  E-value: 2.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714  23 TYEGPHGQDHWPTSYPECG-GDAQSPINIQTD--SVIFDPDLPAvqphgydQLGTEPLDLHNNGHTVQLSLPP-----TL 94
Cdd:PLN02179  43 TEKGPAEWGKLNPQWKVCStGKYQSPIDLTDErvSLIHDQALSR-------HYKPAPAVIQSRGHDVMVSWKGdagkiTI 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922714  95 HlgglPRKYTAAQLHLHwgqrgslEGSEHQINSEATAAELHVVHYDSQSYSslseaaqkpqglAVLGILIEVGETeNPAY 174
Cdd:PLN02179 116 H----QTDYKLVQCHWH-------SPSEHTINGTSYDLELHMVHTSASGKT------------AVVGVLYKLGEP-DEFL 171
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568922714 175 DHILSRLHEIRYKDQKTS-VPPFSVRelfpQQLEQFFRYNGSLTTPPCYQSVLWTVFNR 232
Cdd:PLN02179 172 TKLLNGIKGVGKKEINLGiVDPRDIR----FETNNFYRYIGSLTIPPCTEGVIWTVVKR 226
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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