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Conserved domains on  [gi|568923752|ref|XP_006501998|]
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metal cation symporter ZIP8 isoform X2 [Mus musculus]

Protein Classification

ZIP family transporter( domain architecture ID 579)

ZIP family transporter may function as a zinc transporter, mediating the uptake of zinc in bacteria or the transport of zinc from one cellular compartment to another in eukaryotes

Gene Ontology:  GO:0046873|GO:0030001
PubMed:  23046653|10748254
TCDB:  2.A.5

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Zip super family cl00437
ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative ...
 126-282 1.02e-19

ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative metal transporters. The main contribution to this family is from the Arabidopsis thaliana ZIP protein family these proteins are responsible for zinc uptake in the plant. Also found within this family are C. elegans proteins of unknown function which are annotated as being similar to human growth arrest inducible gene product, although this protein in not found within this family.


The actual alignment was detected with superfamily member pfam02535:

Pssm-ID: 444905 [Multi-domain]  Cd Length: 325  Bit Score: 87.05  E-value: 1.02e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923752  126 SEVWGYGFLSVTIINLASLLGLILTPLIKKS-YFPKILTYFVGLAIGTLFSNAIFQLIPEAFGFNPKID------NYVEK 198
Cdd:pfam02535   1 LLLKIYAIFAILIISLIGGLLPLLVPKISKLrPSSKLLSLLLAFASGVLLGTAFLHLLPEALEALESLClsdhgwHFPFA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923752  199 AVAVFGGFYMLFFVERTLkmllktygqndhTHFRNDDFGSKEKTHQPKTLPLPAVNGVTCYANPAVTEPNGHIHFDTVSV 278
Cdd:pfam02535  81 GLIVLLGFLLVLLVEKLL------------TYYKHRPTPGPADNSHSHLATVKSVSNVEVTESEEGEDHGHLHGHDDDSD 148


                  ....
gi 568923752  279 VSLQ 282
Cdd:pfam02535 149 ELLH 152
 
Name Accession Description Interval E-value
Zip pfam02535
ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative ...
 126-282 1.02e-19

ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative metal transporters. The main contribution to this family is from the Arabidopsis thaliana ZIP protein family these proteins are responsible for zinc uptake in the plant. Also found within this family are C. elegans proteins of unknown function which are annotated as being similar to human growth arrest inducible gene product, although this protein in not found within this family.


Pssm-ID: 396884 [Multi-domain]  Cd Length: 325  Bit Score: 87.05  E-value: 1.02e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923752  126 SEVWGYGFLSVTIINLASLLGLILTPLIKKS-YFPKILTYFVGLAIGTLFSNAIFQLIPEAFGFNPKID------NYVEK 198
Cdd:pfam02535   1 LLLKIYAIFAILIISLIGGLLPLLVPKISKLrPSSKLLSLLLAFASGVLLGTAFLHLLPEALEALESLClsdhgwHFPFA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923752  199 AVAVFGGFYMLFFVERTLkmllktygqndhTHFRNDDFGSKEKTHQPKTLPLPAVNGVTCYANPAVTEPNGHIHFDTVSV 278
Cdd:pfam02535  81 GLIVLLGFLLVLLVEKLL------------TYYKHRPTPGPADNSHSHLATVKSVSNVEVTESEEGEDHGHLHGHDDDSD 148


                  ....
gi 568923752  279 VSLQ 282
Cdd:pfam02535 149 ELLH 152
ZupT COG0428
Zinc transporter ZupT [Inorganic ion transport and metabolism];
127-216 4.82e-06

Zinc transporter ZupT [Inorganic ion transport and metabolism];


Pssm-ID: 440197 [Multi-domain]  Cd Length: 243  Bit Score: 46.71  E-value: 4.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923752 127 EVWGYGFLSVTIINLASLLGLILTPLIKKSyFPKILTYFVGLAIGTLFSNAIFQLIPEAFGfnpKIDNYVEKAVAVFGGF 206
Cdd:COG0428    2 SPLLLALLAGLLAGLATLLGALLALFFKRL-SKRLLSLLLGFAAGVMLAASFFELLPEALE---LGEGPLLAALGFLLGA 77

                         90
                 ....*....|
gi 568923752 207 YMLFFVERTL 216
Cdd:COG0428   78 LLLFLLDRLL 87
 
Name Accession Description Interval E-value
Zip pfam02535
ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative ...
 126-282 1.02e-19

ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative metal transporters. The main contribution to this family is from the Arabidopsis thaliana ZIP protein family these proteins are responsible for zinc uptake in the plant. Also found within this family are C. elegans proteins of unknown function which are annotated as being similar to human growth arrest inducible gene product, although this protein in not found within this family.


Pssm-ID: 396884 [Multi-domain]  Cd Length: 325  Bit Score: 87.05  E-value: 1.02e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923752  126 SEVWGYGFLSVTIINLASLLGLILTPLIKKS-YFPKILTYFVGLAIGTLFSNAIFQLIPEAFGFNPKID------NYVEK 198
Cdd:pfam02535   1 LLLKIYAIFAILIISLIGGLLPLLVPKISKLrPSSKLLSLLLAFASGVLLGTAFLHLLPEALEALESLClsdhgwHFPFA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923752  199 AVAVFGGFYMLFFVERTLkmllktygqndhTHFRNDDFGSKEKTHQPKTLPLPAVNGVTCYANPAVTEPNGHIHFDTVSV 278
Cdd:pfam02535  81 GLIVLLGFLLVLLVEKLL------------TYYKHRPTPGPADNSHSHLATVKSVSNVEVTESEEGEDHGHLHGHDDDSD 148


                  ....
gi 568923752  279 VSLQ 282
Cdd:pfam02535 149 ELLH 152
ZupT COG0428
Zinc transporter ZupT [Inorganic ion transport and metabolism];
127-216 4.82e-06

Zinc transporter ZupT [Inorganic ion transport and metabolism];


Pssm-ID: 440197 [Multi-domain]  Cd Length: 243  Bit Score: 46.71  E-value: 4.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923752 127 EVWGYGFLSVTIINLASLLGLILTPLIKKSyFPKILTYFVGLAIGTLFSNAIFQLIPEAFGfnpKIDNYVEKAVAVFGGF 206
Cdd:COG0428    2 SPLLLALLAGLLAGLATLLGALLALFFKRL-SKRLLSLLLGFAAGVMLAASFFELLPEALE---LGEGPLLAALGFLLGA 77

                         90
                 ....*....|
gi 568923752 207 YMLFFVERTL 216
Cdd:COG0428   78 LLLFLLDRLL 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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