BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944440   4 EEMVQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAvrpevGPEVQQLRGLSAPGLRLVLDFINAGGAREGWGLSEDE 83
Cdd:cd18319    1 EETVQIRLEDRCYNVSKRKLIEQSDYFRALYRSGMRES-----GEEVVQLRGLSAPGLELVLDFINTSKVHESQGDSTDT 75

                         90
                 ....*....|....*...
gi 568944440  84 LAEASVLSEMVEAASFLQ 101
Cdd:cd18319   76 LEENELLEDLVEAASFLQ 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944440   4 EEMVQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAvrpevGPEVQQLRGLSAPGLRLVLDFINAGGAREGWGLSEDE 83
Cdd:cd18319    1 EETVQIRLEDRCYNVSKRKLIEQSDYFRALYRSGMRES-----GEEVVQLRGLSAPGLELVLDFINTSKVHESQGDSTDT 75

                         90
                 ....*....|....*...
gi 568944440  84 LAEASVLSEMVEAASFLQ 101
Cdd:cd18319   76 LEENELLEDLVEAASFLQ 93

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 568944440   118 CLELYRLAQVYGLPDLQDACLRFMVLRFHQVLCQPQFpLLLSPPQ 162
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEF-LELPLEQ 44

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568944440 223 NLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAahsYNPITNEWLQVASMNQKRsqHEHPAVLP 289
Cdd:COG3055  189 TLAPLPTARAGHAAAVLGGKILVFGGESGFSDEVEA---YDPATNTWTALGELPTPR--HGHAAVLT 250

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944440    7 VQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFINAggareGWGLSEDELAE 86
Cdd:pfam00651  13 VTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEI-----TLDDVSPEDFEALLEFMYT-----GKLISEENVDD 82

                          90       100
                  ....*....|....*....|..
gi 568944440   87 asVLsemvEAASFLQVTALLRL 108
Cdd:pfam00651  83 --LL----AAADKLQIPSLVDK 98

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 568944440  118 CLELYRLAQVYGLPDLQDACLRFMVLRFHQVLCQPQFpLLLSP 160
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEF-LELSL 42

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944440   4 EEMVQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAvrpevGPEVQQLRGLSAPGLRLVLDFINAGGAREGWGLSEDE 83
Cdd:cd18319    1 EETVQIRLEDRCYNVSKRKLIEQSDYFRALYRSGMRES-----GEEVVQLRGLSAPGLELVLDFINTSKVHESQGDSTDT 75

                         90
                 ....*....|....*...
gi 568944440  84 LAEASVLSEMVEAASFLQ 101
Cdd:cd18319   76 LEENELLEDLVEAASFLQ 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 13 (KBTBD13); KBTBD13 is a muscle specific protein. Its autosomal dominant mutations may cause Nemaline Myopathy (NEM). KBTBD13 may act as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that functions as a muscle specific ubiquitin ligase, and thereby implicating the ubiquitin proteasome pathway in the pathogenesis of KBTBD13-associated NEM. KBTBD13 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944440   5 EMVQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFINAggarEGWGLSEDEL 84
Cdd:cd18320    2 QKVKVWVEEQLFTVDKALLVENSEYFRALFRSGMRECTQDEI-----RLQGLSARGFRIMLRVLAG----ERPILNGEEI 72

                         90
                 ....*....|....*..
gi 568944440  85 AEAsvlsemVEAASFLQ 101
Cdd:cd18320   73 LQA------IECAAFLQ 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944440  13 DRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFINAGGAregwGLSEDElaeasvLSE 92
Cdd:cd18239   34 DETFPVHRAMMASASDYFKAMFTGGMKEQELMCI-----KLHGVSKIGLKNIIDFIYTAKL----SLNMDN------LQD 98

                         90       100       110
                 ....*....|....*....|....*....|
gi 568944440  93 MVEAASFLQVTALL----RLLLSHVRLGNC 118
Cdd:cd18239   99 TLEAASFLQILPVLdfckVLLISGVTLENC 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568944440   7 VQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFI 68
Cdd:cd18186    4 VTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEI-----ELDDVSPEAFEALLDYI 60

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944440  16 YPVSKSKLIEQSDYFRALYRSGMREAvrpevGPEVQQLRGLSAPGLRLVLDFINAggareGW-GLSEDelaeasVLSEMV 94
Cdd:cd18264   40 FPAHRSLLACSSDYFRALFKDYTQES-----KARVIHLPVVSAAGLQRVLDFIYT-----SWlSLSLD------TLEDTL 103

                         90       100
                 ....*....|....*....|....*...
gi 568944440  95 EAASFLQVTALLRL----LLSHVRLGNC 118
Cdd:cd18264  104 EAASYLQVTEAIGLcsqyLINNLAPENC 131

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944440   7 VQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFINAggaregwglsedELAE 86
Cdd:cd18242   24 VTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEV-----ELQGLTASTMEILLDFVYT------------ETVH 86

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 568944440  87 ASV--LSEMVEAASFLQVT----ALLRLLLSHVRLGNC 118
Cdd:cd18242   87 VTVenVQELLPAACLLQLKgvkqACCEFLESQLDPSNC 124

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 568944440  232 RGYGSAILDNYLFIVGGYRiTSQEISAAHSYNPITNEWLQVASMN 276
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFD-GNQSLNSVEVYDPETNTWSKLPSMP 46

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944440  12 EDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFINAGGAregwglsedeLAEASVLS 91
Cdd:cd18261   36 EEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEV-----NLHGVTSLGLKQALDFAYTGQI----------LLEPGVIQ 100

                         90
                 ....*....|....*..
gi 568944440  92 EMVEAASFLQVTALLRL 108
Cdd:cd18261  101 DVLAAGSHLQLLELLSL 117

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944440  27 SDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFINAGGAREGWGlsedELAEASvlsemvEAASFLQVTALL 106
Cdd:cd18263   36 SDYFRAMFTSGMKESTQSVV-----QLPTIPAKDLRLLISFAYSGILHLSWE----NLFEAT------CTALQLQISGAL 100

                 ....
gi 568944440 107 RLLL 110
Cdd:cd18263  101 ALCL 104

Galactose oxidase, central domain;

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 568944440  240 DNYLFIVGGYRITSQE-ISAAHSYNPITNEWLQVASMNQKRSQH 282
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTrLNDLYVYDLDTNTWTQIGDLPPPRSGH 44

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 568944440 113 VRLGNCLELYRLAQVYGLPDLQDACLRFMVLRFHQVLCQPQF 154
Cdd:cd18480    1 LDLSNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEF 42

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944440   7 VQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFINAGgaregwglsEDELAE 86
Cdd:cd18256   23 VQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVV-----QIHGVEPDIFHILLDFIYTG---------VVEVTV 88

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568944440  87 ASVlSEMVEAASFLQVTALLRL----LLSHVRLGNCL 119
Cdd:cd18256   89 SNV-QELLVAADMLQLTEVVEIccefLKGQLHPSNCI 124

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944440    7 VQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFINAggareGWGLSEDELAE 86
Cdd:pfam00651  13 VTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEI-----TLDDVSPEDFEALLEFMYT-----GKLISEENVDD 82

                          90       100
                  ....*....|....*....|..
gi 568944440   87 asVLsemvEAASFLQVTALLRL 108
Cdd:pfam00651  83 --LL----AAADKLQIPSLVDK 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944440  11 LEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFINAGgaregwGLSEDElaeaSVL 90
Cdd:cd18270   33 VEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHV-----HLRNVDAATLQIIITYAYTG------NLAIND----STV 97

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 568944440  91 SEMVEAASFLQVTALLRL----LLSHVRLGNCLEL 121
Cdd:cd18270   98 EQLYETACFLQVEDVLQRcreyLIKKINAENCVRL 132

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944440   7 VQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRpevgpEVQQLRGLSAPGLRLVLDFINAGGARegwgLSEDElae 86
Cdd:cd18272   35 VTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARN-----RVIELKDVSESVFQLLVDYIYHGTVK----LRVEE--- 102

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 568944440  87 asvLSEMVEAASFLQVTALL----RLLLSHVRLGNCLEL 121
Cdd:cd18272  103 ---LQETYEVADMYQLTALFeecsRFLARTVQVRNCLQV 138

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944440 223 NLPPDLVNVRGYGSAILDNYLFIVGGYRiTSQEISAAHSYNPITNEWLQVASMNQKRSQH 282
Cdd:COG3055    5 SLPDLPTPRSEAAAALLDGKVYVAGGLS-GGSASNSFEVYDPATNTWSELAPLPGPPRHH 63

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944440   7 VQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFINAGgaregwglsedelaE 86
Cdd:cd18240   20 VVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVY-----KIPGVSPEMMELIIEYAYTR--------------T 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 568944440  87 ASVLSEMVE----AASFLQVTALLRL----LLSHVRLGNC 118
Cdd:cd18240   81 VPITAENVEellpAADQFNIMGIVKAccdfLEDQLCPENC 120

Kelch domain;

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 568944440   243 LFIVGGYrITSQEISAAHSYNPITNEWLQVASMNQKRS 280
Cdd:smart00612   2 IYVVGGF-DGGQRLKSVEVYDPETNKWTPLPSMPTPRS 38

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944440  12 EDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFINAG 71
Cdd:cd18266   33 DEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEV-----ELVGASYIGLKAVIDFLYSS 87

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11, also termed chronic myelogenous leukemia-associated protein (CMLAP), or Kelch domain-containing protein 7B, or KLHDC7C, is a BTB-Kelch family protein. Its function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk; KBTBD11 may function as a tumor suppressor. KBTBD11 hypomethylation may also be a potential target for differentiating between the mostly fatal TCF3-HLF and curable TCF3-PBX1 pediatric acute lymphoblastic leukemia subtypes.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568944440 115 LGNCLELYRLAQVYGLPDLQDACLRFMVLRFHQVLCQPQFPLLLSPPQApgDCSLKQRLREAR 177
Cdd:cd18484    3 LGNCYEVLTLAKKQRLNELREAAYKFMSDNYLQVLREPAVYGRLSGAER--ELILRRRLEAGR 63

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental process. It may also act as a protein-protein adaptor in a transcription complex and thus may be involved in brain development.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 568944440 118 CLELyrlAQVYGLPDLQDACLRFMVLRFHQVLCQPQFPLLlsPPQAPGDC 167
Cdd:cd18490    8 CLPL---AHTFGLEDLYEKCLRWIAKHFAKVWSTKSFASL--PPELQEKC 52

kelch-like protein; Provisional

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568944440 209 RYEETTERWFPLaNNLPPDLVNvrgyGSAIL-DNYLFIVGGYRITSQ--EISAAHSYNPITNEWLQVASMNQKR 279
Cdd:PHA03098 410 CFSLNTNKWSKG-SPLPISHYG----GCAIYhDGKIYVIGGISYIDNikVYNIVESYNPVTNKWTELSSLNFPR 478

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944440   4 EEM--VQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpEVQQLRglsAPGLRLVLDFINAGGAregwglsE 81
Cdd:cd18297   10 PEMsdVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVI--EIPDIR---YDIFQLMMQYLYTGGV-------E 77

                         90       100
                 ....*....|....*....|....*..
gi 568944440  82 DELAEASVLSEMVEAASFLQVTALLRL 108
Cdd:cd18297   78 SLDVAQDDALELLRAASFFQLDGLKRH 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944440   9 IRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVGpevqQLRGLSAPGLRLVLDFINAGgaregwglsEDELAEAS 88
Cdd:cd18329   26 ILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVA----TFDVFSPDTFTIILDFVYSG---------KLSLTSQN 92

                         90
                 ....*....|....*...
gi 568944440  89 VLsEMVEAASFLQVTALL 106
Cdd:cd18329   93 VI-EVMSAASYLQMTDVI 109