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Conserved domains on  [gi|568951347|ref|XP_006508241|]
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chordin-like protein 2 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 96-158 1.27e-08

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


:

Pssm-ID: 278520  Cd Length: 57  Bit Score: 50.12  E-value: 1.27e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568951347   96 CTHNGKTYSHGEVWHPTvlsfgpmPCILCTCIDGYQDCHRVTCPTQyPCSQPKKV--AGKCCKIC 158
Cdd:pfam00093   1 CVQNGVVYENGETWKPD-------LCTICTCDDGKVLCDKIICPPL-DCPNPRLEipPGECCPVC 57
CHRDL_1_2_C super family cl44960
Chordin-like protein 1/2 C-terminal; This is the C-terminal domain of Chordin-like proteins 1 ...
 193-261 3.61e-07

Chordin-like protein 1/2 C-terminal; This is the C-terminal domain of Chordin-like proteins 1 and 2. These proteins can bind BMPs family ligands and inhibit its activity by blocking their interaction with their receptors. They are involved in myoblast and osteoblast differentiation and maturation.


The actual alignment was detected with superfamily member pfam19548:

Pssm-ID: 437380  Cd Length: 120  Bit Score: 47.88  E-value: 3.61e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568951347  193 DSLHRFVLEHEASDQVEMYIWKLVKGIYHLVQIKRVRKQDFQKEAqNFRLLTGTHEGYWTVFLAQTPEL 261
Cdd:pfam19548  23 ETTRKIALETERPPQVEVHVWTIRKGILHHFHIEKISKREFEELG-HFKLLTRTTLSQWKIFSEGEAQI 90
 
Name Accession Description Interval E-value
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 96-158 1.27e-08

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 50.12  E-value: 1.27e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568951347   96 CTHNGKTYSHGEVWHPTvlsfgpmPCILCTCIDGYQDCHRVTCPTQyPCSQPKKV--AGKCCKIC 158
Cdd:pfam00093   1 CVQNGVVYENGETWKPD-------LCTICTCDDGKVLCDKIICPPL-DCPNPRLEipPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
96-158 1.37e-07

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 47.51  E-value: 1.37e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568951347    96 CTHNGKTYSHGEVWHPTvlsfgpmPCILCTCIDGYQ-DCHRVTCPTQYPCSQP--KKVAGKCCKIC 158
Cdd:smart00214   1 CVHNGRVYNDGETWKPD-------PCQICTCLDGTTvLCDPVECPPPPDCPNPerVKPPGECCPRC 59
CHRDL_1_2_C pfam19548
Chordin-like protein 1/2 C-terminal; This is the C-terminal domain of Chordin-like proteins 1 ...
 193-261 3.61e-07

Chordin-like protein 1/2 C-terminal; This is the C-terminal domain of Chordin-like proteins 1 and 2. These proteins can bind BMPs family ligands and inhibit its activity by blocking their interaction with their receptors. They are involved in myoblast and osteoblast differentiation and maturation.


Pssm-ID: 437380  Cd Length: 120  Bit Score: 47.88  E-value: 3.61e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568951347  193 DSLHRFVLEHEASDQVEMYIWKLVKGIYHLVQIKRVRKQDFQKEAqNFRLLTGTHEGYWTVFLAQTPEL 261
Cdd:pfam19548  23 ETTRKIALETERPPQVEVHVWTIRKGILHHFHIEKISKREFEELG-HFKLLTRTTLSQWKIFSEGEAQI 90
 
Name Accession Description Interval E-value
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 96-158 1.27e-08

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 50.12  E-value: 1.27e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568951347   96 CTHNGKTYSHGEVWHPTvlsfgpmPCILCTCIDGYQDCHRVTCPTQyPCSQPKKV--AGKCCKIC 158
Cdd:pfam00093   1 CVQNGVVYENGETWKPD-------LCTICTCDDGKVLCDKIICPPL-DCPNPRLEipPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
96-158 1.37e-07

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 47.51  E-value: 1.37e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568951347    96 CTHNGKTYSHGEVWHPTvlsfgpmPCILCTCIDGYQ-DCHRVTCPTQYPCSQP--KKVAGKCCKIC 158
Cdd:smart00214   1 CVHNGRVYNDGETWKPD-------PCQICTCLDGTTvLCDPVECPPPPDCPNPerVKPPGECCPRC 59
CHRDL_1_2_C pfam19548
Chordin-like protein 1/2 C-terminal; This is the C-terminal domain of Chordin-like proteins 1 ...
 193-261 3.61e-07

Chordin-like protein 1/2 C-terminal; This is the C-terminal domain of Chordin-like proteins 1 and 2. These proteins can bind BMPs family ligands and inhibit its activity by blocking their interaction with their receptors. They are involved in myoblast and osteoblast differentiation and maturation.


Pssm-ID: 437380  Cd Length: 120  Bit Score: 47.88  E-value: 3.61e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568951347  193 DSLHRFVLEHEASDQVEMYIWKLVKGIYHLVQIKRVRKQDFQKEAqNFRLLTGTHEGYWTVFLAQTPEL 261
Cdd:pfam19548  23 ETTRKIALETERPPQVEVHVWTIRKGILHHFHIEKISKREFEELG-HFKLLTRTTLSQWKIFSEGEAQI 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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