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Conserved domains on  [gi|568954843|ref|XP_006509493|]
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WD repeat-containing protein 17 isoform X5 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
259-584 3.46e-62

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 218.24  E-value: 3.46e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  259 AFSLPPGHVVCCFLDGGVGLYDMGAKKWDFLRElGHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPGNE 338
Cdd:COG2319    85 AFSPDGRLLASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  339 GVIFALSWAP-GDLncIAGATSRNGAFIWDIQKGKIIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCIIRTVD-GKL 416
Cdd:COG2319   163 GAVTSVAFSPdGKL--LASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSP-DGKLLASGSADGTVRLWDLAtGKL 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  417 LHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFYVATssNQPLKVFSGHTARVFHVKWSPlrEG-ILCSGSDDGSVR 494
Cdd:COG2319   239 LRTLTgHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLAT--GELLRTLTGHSGGVNSVAFSP--DGkLLASGSDDGTVR 313

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  495 IWDYTQDACVSTLNGHTAPVRGLMWNteiPY--LLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMAS 572
Cdd:COG2319   314 LWDLATGKLLRTLTGHTGAVRSVAFS---PDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLAS 389

                         330
                  ....*....|..
gi 568954843  573 CSRDSTVRLWSL 584
Cdd:COG2319   390 GSADGTVRLWDL 401
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 90-405 6.67e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 79.69  E-value: 6.67e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843   90 KVAFGHIDGSISIFQPGSKNQKHVLrpdslegTDEEDPVTALEWDPlSTDYLLVANLHFGIRLLDSESLYCITTFNLPSA 169
Cdd:cd00200    65 YLASGSSDKTIRLWDLETGECVRTL-------TGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  170 AVSvqCLAWVPSapGMFITGDSQVGVLRIWNVSRTTPIDNFKlkktgfhcfhvvnsppkkkfsvqspnknhyisstseav 249
Cdd:cd00200   137 WVN--SVAFSPD--GTFVASSSQDGTIKLWDLRTGKCVATLT-------------------------------------- 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  250 pppnltqnqafslppghvvccfldggvglydmgakkwdflrelGHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLT 329
Cdd:cd00200   175 -------------------------------------------GHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDLSTGK 210

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568954843  330 AVYTSPGNEGVIFALSWAPGDLNCIAGatSRNGAF-IWDIQKGKIIQRFNEHgKNGIFYIAWShKDSKRIATCSGDG 405
Cdd:cd00200   211 CLGTLRGHENGVNSVAFSPDGYLLASG--SEDGTIrVWDLRTGECVQTLSGH-TNSVTSLAWS-PDGKRLASGSADG 283
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
259-584 3.46e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 218.24  E-value: 3.46e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  259 AFSLPPGHVVCCFLDGGVGLYDMGAKKWDFLRElGHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPGNE 338
Cdd:COG2319    85 AFSPDGRLLASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  339 GVIFALSWAP-GDLncIAGATSRNGAFIWDIQKGKIIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCIIRTVD-GKL 416
Cdd:COG2319   163 GAVTSVAFSPdGKL--LASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSP-DGKLLASGSADGTVRLWDLAtGKL 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  417 LHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFYVATssNQPLKVFSGHTARVFHVKWSPlrEG-ILCSGSDDGSVR 494
Cdd:COG2319   239 LRTLTgHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLAT--GELLRTLTGHSGGVNSVAFSP--DGkLLASGSDDGTVR 313

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  495 IWDYTQDACVSTLNGHTAPVRGLMWNteiPY--LLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMAS 572
Cdd:COG2319   314 LWDLATGKLLRTLTGHTGAVRSVAFS---PDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLAS 389

                         330
                  ....*....|..
gi 568954843  573 CSRDSTVRLWSL 584
Cdd:COG2319   390 GSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 293-583 2.64e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 202.95  E-value: 2.64e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  293 GHVETIFDCKFKPDdPNVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSWAPgDLNCIAGATSRNGAFIWDIQKGK 372
Cdd:cd00200     7 GHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  373 IIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCII-RTVDGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRV 450
Cdd:cd00200    85 CVRTLTGH-TSYVSSVAFSP-DGRILSSSSRDKTIKVwDVETGKCLTTLRgHTDWVNSVAFSPDGT-FVASSSQDGTIKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  451 FyvATSSNQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEiPYLLISG 530
Cdd:cd00200   162 W--DLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASG 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568954843  531 SWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMASCSRDSTVRLWS 583
Cdd:cd00200   238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 90-405 6.67e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.69  E-value: 6.67e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843   90 KVAFGHIDGSISIFQPGSKNQKHVLrpdslegTDEEDPVTALEWDPlSTDYLLVANLHFGIRLLDSESLYCITTFNLPSA 169
Cdd:cd00200    65 YLASGSSDKTIRLWDLETGECVRTL-------TGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  170 AVSvqCLAWVPSapGMFITGDSQVGVLRIWNVSRTTPIDNFKlkktgfhcfhvvnsppkkkfsvqspnknhyisstseav 249
Cdd:cd00200   137 WVN--SVAFSPD--GTFVASSSQDGTIKLWDLRTGKCVATLT-------------------------------------- 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  250 pppnltqnqafslppghvvccfldggvglydmgakkwdflrelGHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLT 329
Cdd:cd00200   175 -------------------------------------------GHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDLSTGK 210

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568954843  330 AVYTSPGNEGVIFALSWAPGDLNCIAGatSRNGAF-IWDIQKGKIIQRFNEHgKNGIFYIAWShKDSKRIATCSGDG 405
Cdd:cd00200   211 CLGTLRGHENGVNSVAFSPDGYLLASG--SEDGTIrVWDLRTGECVQTLSGH-TNSVTSLAWS-PDGKRLASGSADG 283
WD40 COG2319
WD40 repeat [General function prediction only];
54-327 5.06e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.17  E-value: 5.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843   54 LIWTISGPDSGV-SVhkeahSFASDicifrwhtqkkGK-VAFGHIDGSISIFQPGSKNQKHVLRPDSlegtdeeDPVTAL 131
Cdd:COG2319   154 LLRTLTGHSGAVtSV-----AFSPD-----------GKlLASGSDDGTVRLWDLATGKLLRTLTGHT-------GAVRSV 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  132 EWDPlstD--YLLVANLHFGIRLLDSESLYCITTFNLPSAAVSvqCLAWVPSapGMFITGDSQVGVLRIWNVSRTTPIDN 209
Cdd:COG2319   211 AFSP---DgkLLASGSADGTVRLWDLATGKLLRTLTGHSGSVR--SVAFSPD--GRLLASGSADGTVRLWDLATGELLRT 283

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  210 FKlkktgfHCFHVVNSppkkkfsVQ-SPNkNHYISSTSE--AVPPPNLTQNQAFSLPPGHV-----VCCFLDGG---VGL 278
Cdd:COG2319   284 LT------GHSGGVNS-------VAfSPD-GKLLASGSDdgTVRLWDLATGKLLRTLTGHTgavrsVAFSPDGKtlaSGS 349

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568954843  279 YDMGAKKWDF-----LREL-GHVETIFDCKFKPDDpNVLATASFDGTIKVWDINT 327
Cdd:COG2319   350 DDGTVRLWDLatgelLRTLtGHTGAVTSVAFSPDG-RTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 457-497 1.77e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 1.77e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 568954843    457 SNQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWD 497
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 431-584 1.09e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 56.25  E-value: 1.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  431 WSQNNKDMIATGCEDKNIRVFYVAtsSNQPLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQDACVSTLNGh 510
Cdd:PLN00181  540 WNSYIKSQVASSNFEGVVQVWDVA--RSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT- 616

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568954843  511 TAPVRGLMWNTEIPYLLISGSWDYTIKVWDTRG-GVCLDTVYDHGADVYGLTCHPSRpfTMASCSRDSTVRLWSL 584
Cdd:PLN00181  617 KANICCVQFPSESGRSLAFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFVDSS--TLVSSSTDNTLKLWDL 689
WD40 pfam00400
WD domain, G-beta repeat;
458-497 6.04e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 6.04e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568954843   458 NQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWD 497
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
259-584 3.46e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 218.24  E-value: 3.46e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  259 AFSLPPGHVVCCFLDGGVGLYDMGAKKWDFLRElGHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPGNE 338
Cdd:COG2319    85 AFSPDGRLLASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  339 GVIFALSWAP-GDLncIAGATSRNGAFIWDIQKGKIIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCIIRTVD-GKL 416
Cdd:COG2319   163 GAVTSVAFSPdGKL--LASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSP-DGKLLASGSADGTVRLWDLAtGKL 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  417 LHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFYVATssNQPLKVFSGHTARVFHVKWSPlrEG-ILCSGSDDGSVR 494
Cdd:COG2319   239 LRTLTgHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLAT--GELLRTLTGHSGGVNSVAFSP--DGkLLASGSDDGTVR 313

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  495 IWDYTQDACVSTLNGHTAPVRGLMWNteiPY--LLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMAS 572
Cdd:COG2319   314 LWDLATGKLLRTLTGHTGAVRSVAFS---PDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLAS 389

                         330
                  ....*....|..
gi 568954843  573 CSRDSTVRLWSL 584
Cdd:COG2319   390 GSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 293-583 2.64e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 202.95  E-value: 2.64e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  293 GHVETIFDCKFKPDdPNVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSWAPgDLNCIAGATSRNGAFIWDIQKGK 372
Cdd:cd00200     7 GHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  373 IIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCII-RTVDGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRV 450
Cdd:cd00200    85 CVRTLTGH-TSYVSSVAFSP-DGRILSSSSRDKTIKVwDVETGKCLTTLRgHTDWVNSVAFSPDGT-FVASSSQDGTIKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  451 FyvATSSNQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEiPYLLISG 530
Cdd:cd00200   162 W--DLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASG 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568954843  531 SWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMASCSRDSTVRLWS 583
Cdd:cd00200   238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
259-543 5.47e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 188.58  E-value: 5.47e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  259 AFSlPPGH-VVCCFLDGGVGLYDMGAKKwdFLREL-GHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPG 336
Cdd:COG2319   127 AFS-PDGKtLASGSADGTVRLWDLATGK--LLRTLtGHSGAVTSVAFSPDG-KLLASGSDDGTVRLWDLATGKLLRTLTG 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  337 NEGVIFALSWAPgDLNCIAGATSRNGAFIWDIQKGKIIQRFNEHGkNGIFYIAWSHkDSKRIATCSGDG-FCIIRTVDGK 415
Cdd:COG2319   203 HTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHS-GSVRSVAFSP-DGRLLASGSADGtVRLWDLATGE 279

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  416 LLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFYVATssNQPLKVFSGHTARVFHVKWSPLREgILCSGSDDGSVR 494
Cdd:COG2319   280 LLRTLTgHSGGVNSVAFSPDGK-LLASGSDDGTVRLWDLAT--GKLLRTLTGHTGAVRSVAFSPDGK-TLASGSDDGTVR 355

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 568954843  495 IWDYTQDACVSTLNGHTAPVRGLMWNTEIPYLlISGSWDYTIKVWDTRG 543
Cdd:COG2319   356 LWDLATGELLRTLTGHTGAVTSVAFSPDGRTL-ASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 259-540 5.60e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 164.43  E-value: 5.60e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  259 AFSLPPGHVVCCFLDGGVGLYDMgAKKWDFLRELGHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPGNE 338
Cdd:cd00200    16 AFSPDGKLLATGSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGECVRTLTGHT 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  339 GVIFALSWAPgDLNCIAGATSRNGAFIWDIQKGKIIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCII-RTVDGKLL 417
Cdd:cd00200    94 SYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSP-DGTFVASSSQDGTIKLwDLRTGKCV 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  418 HKYK-HPAAVFGCDWSQNNKDMIATGCeDKNIRVFYVATSsnQPLKVFSGHTARVFHVKWSPLREgILCSGSDDGSVRIW 496
Cdd:cd00200   171 ATLTgHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDLSTG--KCLGTLRGHENGVNSVAFSPDGY-LLASGSEDGTIRVW 246

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 568954843  497 DYTQDACVSTLNGHTAPVRGLMWNTEIPYlLISGSWDYTIKVWD 540
Cdd:cd00200   247 DLRTGECVQTLSGHTNSVTSLAWSPDGKR-LASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 333-584 5.29e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 161.73  E-value: 5.29e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  333 TSPGNEGVIFALSWAPgDLNCIAGATSRNGAFIWDIQKGKIIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCII-RT 411
Cdd:cd00200     4 TLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGH-TGPVRDVAASA-DGTYLASGSSDKTIRLwDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  412 VDGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFYVATssNQPLKVFSGHTARVFHVKWSPlREGILCSGSDD 490
Cdd:cd00200    81 ETGECVRTLTgHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVET--GKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  491 GSVRIWDYTQDACVSTLNGHTAPVRGLMWnTEIPYLLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPFtM 570
Cdd:cd00200   157 GTIKLWDLRTGKCVATLTGHTGEVNSVAF-SPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYL-L 234

                         250
                  ....*....|....
gi 568954843  571 ASCSRDSTVRLWSL 584
Cdd:cd00200   235 ASGSEDGTIRVWDL 248
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 374-584 3.77e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 147.48  E-value: 3.77e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  374 IQRFNEHGKnGIFYIAWsHKDSKRIATCSGDGFCII-RTVDGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVF 451
Cdd:cd00200     2 RRTLKGHTG-GVTCVAF-SPDGKLLATGSGDGTIKVwDLETGELLRTLKgHTGPVRDVAASADGT-YLASGSSDKTIRLW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  452 yvATSSNQPLKVFSGHTARVFHVKWSPLREgILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEiPYLLISGS 531
Cdd:cd00200    79 --DLETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSS 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568954843  532 WDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRpFTMASCSRDSTVRLWSL 584
Cdd:cd00200   155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDL 206
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 460-585 2.32e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 119.36  E-value: 2.32e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  460 PLKVFSGHTARVFHVKWSPLREgILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWnteIPY--LLISGSWDYTIK 537
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGK-LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAA---SADgtYLASGSSDKTIR 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 568954843  538 VWDTRGGVCLDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLWSLI 585
Cdd:cd00200    77 LWDLETGECVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVE 123
WD40 COG2319
WD40 repeat [General function prediction only];
347-584 3.03e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.94  E-value: 3.03e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  347 APGDLNCIAGATSRNGAFIWDIQKGKIIQRFNEHGkNGIFYIAWSHKDSKRIATCSGDGFCIIRTVDGKLLHKYK-HPAA 425
Cdd:COG2319     2 LSADGAALAAASADLALALLAAALGALLLLLLGLA-AAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLgHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  426 VFGCDWSQNNKdMIATGCEDKNIRVFYVATSsnQPLKVFSGHTARVFHVKWSPLREGILcSGSDDGSVRIWDYTQDACVS 505
Cdd:COG2319    81 VLSVAFSPDGR-LLASASADGTVRLWDLATG--LLLRTLTGHTGAVRSVAFSPDGKTLA-SGSADGTVRLWDLATGKLLR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  506 TLNGHTAPVRGLMWNteiP--YLLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHP-SRpfTMASCSRDSTVRLW 582
Cdd:COG2319   157 TLTGHSGAVTSVAFS---PdgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdGK--LLASGSADGTVRLW 231


                  ..
gi 568954843  583 SL 584
Cdd:COG2319   232 DL 233
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 90-405 6.67e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.69  E-value: 6.67e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843   90 KVAFGHIDGSISIFQPGSKNQKHVLrpdslegTDEEDPVTALEWDPlSTDYLLVANLHFGIRLLDSESLYCITTFNLPSA 169
Cdd:cd00200    65 YLASGSSDKTIRLWDLETGECVRTL-------TGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  170 AVSvqCLAWVPSapGMFITGDSQVGVLRIWNVSRTTPIDNFKlkktgfhcfhvvnsppkkkfsvqspnknhyisstseav 249
Cdd:cd00200   137 WVN--SVAFSPD--GTFVASSSQDGTIKLWDLRTGKCVATLT-------------------------------------- 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  250 pppnltqnqafslppghvvccfldggvglydmgakkwdflrelGHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLT 329
Cdd:cd00200   175 -------------------------------------------GHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDLSTGK 210

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568954843  330 AVYTSPGNEGVIFALSWAPGDLNCIAGatSRNGAF-IWDIQKGKIIQRFNEHgKNGIFYIAWShKDSKRIATCSGDG 405
Cdd:cd00200   211 CLGTLRGHENGVNSVAFSPDGYLLASG--SEDGTIrVWDLRTGECVQTLSGH-TNSVTSLAWS-PDGKRLASGSADG 283
WD40 COG2319
WD40 repeat [General function prediction only];
54-327 5.06e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.17  E-value: 5.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843   54 LIWTISGPDSGV-SVhkeahSFASDicifrwhtqkkGK-VAFGHIDGSISIFQPGSKNQKHVLRPDSlegtdeeDPVTAL 131
Cdd:COG2319   154 LLRTLTGHSGAVtSV-----AFSPD-----------GKlLASGSDDGTVRLWDLATGKLLRTLTGHT-------GAVRSV 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  132 EWDPlstD--YLLVANLHFGIRLLDSESLYCITTFNLPSAAVSvqCLAWVPSapGMFITGDSQVGVLRIWNVSRTTPIDN 209
Cdd:COG2319   211 AFSP---DgkLLASGSADGTVRLWDLATGKLLRTLTGHSGSVR--SVAFSPD--GRLLASGSADGTVRLWDLATGELLRT 283

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  210 FKlkktgfHCFHVVNSppkkkfsVQ-SPNkNHYISSTSE--AVPPPNLTQNQAFSLPPGHV-----VCCFLDGG---VGL 278
Cdd:COG2319   284 LT------GHSGGVNS-------VAfSPD-GKLLASGSDdgTVRLWDLATGKLLRTLTGHTgavrsVAFSPDGKtlaSGS 349

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568954843  279 YDMGAKKWDF-----LREL-GHVETIFDCKFKPDDpNVLATASFDGTIKVWDINT 327
Cdd:COG2319   350 DDGTVRLWDLatgelLRTLtGHTGAVTSVAFSPDG-RTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 457-497 1.77e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 1.77e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 568954843    457 SNQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWD 497
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 431-584 1.09e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 56.25  E-value: 1.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  431 WSQNNKDMIATGCEDKNIRVFYVAtsSNQPLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQDACVSTLNGh 510
Cdd:PLN00181  540 WNSYIKSQVASSNFEGVVQVWDVA--RSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT- 616

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568954843  511 TAPVRGLMWNTEIPYLLISGSWDYTIKVWDTRG-GVCLDTVYDHGADVYGLTCHPSRpfTMASCSRDSTVRLWSL 584
Cdd:PLN00181  617 KANICCVQFPSESGRSLAFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFVDSS--TLVSSSTDNTLKLWDL 689
PTZ00420 PTZ00420
coronin; Provisional
 458-540 1.97e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 55.34  E-value: 1.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  458 NQPLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQD----------ACVstLNGHTAPVRGLMWNTEIPYLL 527
Cdd:PTZ00420   64 KPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNdesvkeikdpQCI--LKGHKKKISIIDWNPMNYYIM 141

                          90
                  ....*....|...
gi 568954843  528 ISGSWDYTIKVWD 540
Cdd:PTZ00420  142 CSSGFDSFVNIWD 154
WD40 pfam00400
WD domain, G-beta repeat;
458-497 6.04e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 6.04e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568954843   458 NQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWD 497
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 503-540 1.23e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 1.23e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 568954843    503 CVSTLNGHTAPVRGLMWNTEIPYLlISGSWDYTIKVWD 540
Cdd:smart00320    4 LLKTLKGHTGPVTSVAFSPDGKYL-ASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
503-540 7.67e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 7.67e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 568954843   503 CVSTLNGHTAPVRGLMWNTEIPYLlISGSWDYTIKVWD 540
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSPDGKLL-ASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 292-380 1.11e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.51  E-value: 1.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  292 LGHVETIFDCKFKPDDPNVLATASFDGTIKVWDINT--LTAVYTSP-----GNEGVIFALSWAPGDLNCIAGATSRNGAF 364
Cdd:PTZ00421   72 LGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEegLTQNISDPivhlqGHTKKVGIVSFHPSAMNVLASAGADMVVN 151

                          90
                  ....*....|....*.
gi 568954843  365 IWDIQKGKIIQRFNEH 380
Cdd:PTZ00421  152 VWDVERGKAVEVIKCH 167
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 365-511 3.90e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.16  E-value: 3.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  365 IWDIQKGKIIQRFNEHGKNgIFYIAWSHKDSKRIATCSGDGFCIIRTVD-GKLLHKYKHPAAVFGCDWSQNNKDMIATGC 443
Cdd:PLN00181  559 VWDVARSQLVTEMKEHEKR-VWSIDYSSADPTLLASGSDDGSVKLWSINqGVSIGTIKTKANICCVQFPSESGRSLAFGS 637

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568954843  444 EDKNIrVFYVATSSNQPLKVFSGHTARVFHVKWspLREGILCSGSDDGSVRIWDYTQDAC------VSTLNGHT 511
Cdd:PLN00181  638 ADHKV-YYYDLRNPKLPLCTMIGHSKTVSYVRF--VDSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHT 708
PTZ00420 PTZ00420
coronin; Provisional
 437-497 5.31e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 47.25  E-value: 5.31e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568954843  437 DMIATGCEDKNIRVFYVATSSNQ------PLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWD 497
Cdd:PTZ00420   88 EILASGSEDLTIRVWEIPHNDESvkeikdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWD 154
PTZ00420 PTZ00420
coronin; Provisional
 491-607 5.68e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 47.25  E-value: 5.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  491 GSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTR-GGVCLDTVYD-------HGADVYGLTC 562
Cdd:PTZ00420   54 GAIRLENQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPhNDESVKEIKDpqcilkgHKKKISIIDW 133

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 568954843  563 HPSRPFTMASCSRDSTVRLWSLIPLITPLQINI---LADRSWDeVIGN 607
Cdd:PTZ00420  134 NPMNYYIMCSSGFDSFVNIWDIENEKRAFQINMpkkLSSLKWN-IKGN 180
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 293-324 1.05e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 1.05e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568954843    293 GHVETIFDCKFKPDDpNVLATASFDGTIKVWD 324
Cdd:smart00320   10 GHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 456-553 1.91e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.65  E-value: 1.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  456 SSNQPLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEiPYLLISGSWDYT 535
Cdd:PTZ00421  113 NISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLD-GSLLCTTSKDKK 191

                          90
                  ....*....|....*...
gi 568954843  536 IKVWDTRGGVCLDTVYDH 553
Cdd:PTZ00421  192 LNIIDPRDGTIVSSVEAH 209
WD40 pfam00400
WD domain, G-beta repeat;
293-324 2.77e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 2.77e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568954843   293 GHVETIFDCKFKPDDpNVLATASFDGTIKVWD 324
Cdd:pfam00400    9 GHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
544-583 2.99e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 2.99e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568954843   544 GVCLDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLWS 583
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 544-583 3.85e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 3.85e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 568954843    544 GVCLDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLWS 583
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 456-581 4.49e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.11  E-value: 4.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  456 SSNQPLKVfsGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQDACVST-------LNGHTAPVRGLMWNTEIPYLLI 528
Cdd:PTZ00421   65 ASNPPILL--GQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNisdpivhLQGHTKKVGIVSFHPSAMNVLA 142

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568954843  529 SGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHpSRPFTMASCSRDSTVRL 581
Cdd:PTZ00421  143 SAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWN-LDGSLLCTTSKDKKLNI 194
PTZ00421 PTZ00421
coronin; Provisional
 293-380 1.49e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.57  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954843  293 GHVETIFDCKFKPDDPNVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSW-APGDLNCiagATSRNGAF-IWDIQK 370
Cdd:PTZ00421  123 GHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWnLDGSLLC---TTSKDKKLnIIDPRD 199

                          90
                  ....*....|
gi 568954843  371 GKIIQRFNEH 380
Cdd:PTZ00421  200 GTIVSSVEAH 209
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 413-451 1.50e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.50e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 568954843    413 DGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVF 451
Cdd:smart00320    1 SGELLKTLKgHTGPVTSVAFSPDGK-YLASGSDDGTIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 516-584 2.42e-03

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.00  E-value: 2.42e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568954843  516 GLMWNTEIPYLLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSL 584
Cdd:PLN00181  537 GICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSI 605
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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