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Conserved domains on  [gi|568954847|ref|XP_006509495|]
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WD repeat-containing protein 17 isoform X7 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
232-557 3.25e-62

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 218.24  E-value: 3.25e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  232 AFSLPPGHVVCCFLDGGVGLYDMGAKKWDFLRElGHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPGNE 311
Cdd:COG2319    85 AFSPDGRLLASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  312 GVIFALSWAP-GDLncIAGATSRNGAFIWDIQKGKIIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCIIRTVD-GKL 389
Cdd:COG2319   163 GAVTSVAFSPdGKL--LASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSP-DGKLLASGSADGTVRLWDLAtGKL 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  390 LHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFYVATssNQPLKVFSGHTARVFHVKWSPlrEG-ILCSGSDDGSVR 467
Cdd:COG2319   239 LRTLTgHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLAT--GELLRTLTGHSGGVNSVAFSP--DGkLLASGSDDGTVR 313

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  468 IWDYTQDACVSTLNGHTAPVRGLMWNteiPY--LLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMAS 545
Cdd:COG2319   314 LWDLATGKLLRTLTGHTGAVRSVAFS---PDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLAS 389

                         330
                  ....*....|..
gi 568954847  546 CSRDSTVRLWSL 557
Cdd:COG2319   390 GSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
74-300 1.11e-12

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.48  E-value: 1.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847   74 KLHAIMSEHKKTITAISWCPHNpDLFASSSTDNLVIIWNVAEQKVIAKLDNIKETPACLGWcwnTHD--AVAFVSQKGPL 151
Cdd:COG2319   195 KLLRTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF---SPDgrLLASGSADGTV 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  152 LIW---------TISGPDSGVSvhkeAHSFASDicifrwhtqkkGK-VAFGHIDGSISIFQPVSVQSPN--KNHYISSTS 219
Cdd:COG2319   271 RLWdlatgellrTLTGHSGGVN----SVAFSPD-----------GKlLASGSDDGTVRLWDLATGKLLRtlTGHTGAVRS 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  220 eaVpppnltqnqAFSlPPG-HVVCCFLDGGVGLYDMGAKKWdfLREL-GHVETIFDCKFKPDDpNVLATASFDGTIKVWD 297
Cdd:COG2319   336 --V---------AFS-PDGkTLASGSDDGTVRLWDLATGEL--LRTLtGHTGAVTSVAFSPDG-RTLASGSADGTVRLWD 400


                  ...
gi 568954847  298 INT 300
Cdd:COG2319   401 LAT 403
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
232-557 3.25e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 218.24  E-value: 3.25e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  232 AFSLPPGHVVCCFLDGGVGLYDMGAKKWDFLRElGHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPGNE 311
Cdd:COG2319    85 AFSPDGRLLASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  312 GVIFALSWAP-GDLncIAGATSRNGAFIWDIQKGKIIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCIIRTVD-GKL 389
Cdd:COG2319   163 GAVTSVAFSPdGKL--LASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSP-DGKLLASGSADGTVRLWDLAtGKL 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  390 LHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFYVATssNQPLKVFSGHTARVFHVKWSPlrEG-ILCSGSDDGSVR 467
Cdd:COG2319   239 LRTLTgHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLAT--GELLRTLTGHSGGVNSVAFSP--DGkLLASGSDDGTVR 313

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  468 IWDYTQDACVSTLNGHTAPVRGLMWNteiPY--LLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMAS 545
Cdd:COG2319   314 LWDLATGKLLRTLTGHTGAVRSVAFS---PDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLAS 389

                         330
                  ....*....|..
gi 568954847  546 CSRDSTVRLWSL 557
Cdd:COG2319   390 GSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 266-556 3.26e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 202.57  E-value: 3.26e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  266 GHVETIFDCKFKPDdPNVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSWAPgDLNCIAGATSRNGAFIWDIQKGK 345
Cdd:cd00200     7 GHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  346 IIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCII-RTVDGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRV 423
Cdd:cd00200    85 CVRTLTGH-TSYVSSVAFSP-DGRILSSSSRDKTIKVwDVETGKCLTTLRgHTDWVNSVAFSPDGT-FVASSSQDGTIKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  424 FyvATSSNQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEiPYLLISG 503
Cdd:cd00200   162 W--DLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASG 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568954847  504 SWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMASCSRDSTVRLWS 556
Cdd:cd00200   238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
74-300 1.11e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.48  E-value: 1.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847   74 KLHAIMSEHKKTITAISWCPHNpDLFASSSTDNLVIIWNVAEQKVIAKLDNIKETPACLGWcwnTHD--AVAFVSQKGPL 151
Cdd:COG2319   195 KLLRTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF---SPDgrLLASGSADGTV 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  152 LIW---------TISGPDSGVSvhkeAHSFASDicifrwhtqkkGK-VAFGHIDGSISIFQPVSVQSPN--KNHYISSTS 219
Cdd:COG2319   271 RLWdlatgellrTLTGHSGGVN----SVAFSPD-----------GKlLASGSDDGTVRLWDLATGKLLRtlTGHTGAVRS 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  220 eaVpppnltqnqAFSlPPG-HVVCCFLDGGVGLYDMGAKKWdfLREL-GHVETIFDCKFKPDDpNVLATASFDGTIKVWD 297
Cdd:COG2319   336 --V---------AFS-PDGkTLASGSDDGTVRLWDLATGEL--LRTLtGHTGAVTSVAFSPDG-RTLASGSADGTVRLWD 400


                  ...
gi 568954847  298 INT 300
Cdd:COG2319   401 LAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 430-470 1.78e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 1.78e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 568954847    430 SNQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWD 470
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 404-557 1.06e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 56.25  E-value: 1.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  404 WSQNNKDMIATGCEDKNIRVFYVAtsSNQPLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQDACVSTLNGh 483
Cdd:PLN00181  540 WNSYIKSQVASSNFEGVVQVWDVA--RSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT- 616

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568954847  484 TAPVRGLMWNTEIPYLLISGSWDYTIKVWDTRG-GVCLDTVYDHGADVYGLTCHPSRpfTMASCSRDSTVRLWSL 557
Cdd:PLN00181  617 KANICCVQFPSESGRSLAFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFVDSS--TLVSSSTDNTLKLWDL 689
WD40 pfam00400
WD domain, G-beta repeat;
431-470 6.09e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 6.09e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568954847   431 NQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWD 470
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 73-112 1.35e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 1.35e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 568954847     73 FKLHAIMSEHKKTITAISWCPHNpDLFASSSTDNLVIIWN 112
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 59-117 2.44e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.86  E-value: 2.44e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568954847   59 LAIYIYQLDHR---YNEFK-LHAIMSEHKKTITAISWCPHNPDLFASSSTDNLVIIWNVAEQK 117
Cdd:PTZ00420   97 LTIRVWEIPHNdesVKEIKdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEK 159
WD40 pfam00400
WD domain, G-beta repeat;
73-112 3.11e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 3.11e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568954847    73 FKLHAIMSEHKKTITAISWCPHNpDLFASSSTDNLVIIWN 112
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
232-557 3.25e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 218.24  E-value: 3.25e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  232 AFSLPPGHVVCCFLDGGVGLYDMGAKKWDFLRElGHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPGNE 311
Cdd:COG2319    85 AFSPDGRLLASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  312 GVIFALSWAP-GDLncIAGATSRNGAFIWDIQKGKIIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCIIRTVD-GKL 389
Cdd:COG2319   163 GAVTSVAFSPdGKL--LASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSP-DGKLLASGSADGTVRLWDLAtGKL 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  390 LHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFYVATssNQPLKVFSGHTARVFHVKWSPlrEG-ILCSGSDDGSVR 467
Cdd:COG2319   239 LRTLTgHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLAT--GELLRTLTGHSGGVNSVAFSP--DGkLLASGSDDGTVR 313

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  468 IWDYTQDACVSTLNGHTAPVRGLMWNteiPY--LLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMAS 545
Cdd:COG2319   314 LWDLATGKLLRTLTGHTGAVRSVAFS---PDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLAS 389

                         330
                  ....*....|..
gi 568954847  546 CSRDSTVRLWSL 557
Cdd:COG2319   390 GSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 266-556 3.26e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 202.57  E-value: 3.26e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  266 GHVETIFDCKFKPDdPNVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSWAPgDLNCIAGATSRNGAFIWDIQKGK 345
Cdd:cd00200     7 GHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  346 IIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCII-RTVDGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRV 423
Cdd:cd00200    85 CVRTLTGH-TSYVSSVAFSP-DGRILSSSSRDKTIKVwDVETGKCLTTLRgHTDWVNSVAFSPDGT-FVASSSQDGTIKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  424 FyvATSSNQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEiPYLLISG 503
Cdd:cd00200   162 W--DLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASG 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568954847  504 SWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMASCSRDSTVRLWS 556
Cdd:cd00200   238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
232-516 5.29e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 188.58  E-value: 5.29e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  232 AFSlPPGH-VVCCFLDGGVGLYDMGAKKwdFLREL-GHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPG 309
Cdd:COG2319   127 AFS-PDGKtLASGSADGTVRLWDLATGK--LLRTLtGHSGAVTSVAFSPDG-KLLASGSDDGTVRLWDLATGKLLRTLTG 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  310 NEGVIFALSWAPgDLNCIAGATSRNGAFIWDIQKGKIIQRFNEHGkNGIFYIAWSHkDSKRIATCSGDG-FCIIRTVDGK 388
Cdd:COG2319   203 HTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHS-GSVRSVAFSP-DGRLLASGSADGtVRLWDLATGE 279

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  389 LLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFYVATssNQPLKVFSGHTARVFHVKWSPLREgILCSGSDDGSVR 467
Cdd:COG2319   280 LLRTLTgHSGGVNSVAFSPDGK-LLASGSDDGTVRLWDLAT--GKLLRTLTGHTGAVRSVAFSPDGK-TLASGSDDGTVR 355

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 568954847  468 IWDYTQDACVSTLNGHTAPVRGLMWNTEIPYLlISGSWDYTIKVWDTRG 516
Cdd:COG2319   356 LWDLATGELLRTLTGHTGAVTSVAFSPDGRTL-ASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 232-513 6.60e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 164.43  E-value: 6.60e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  232 AFSLPPGHVVCCFLDGGVGLYDMgAKKWDFLRELGHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPGNE 311
Cdd:cd00200    16 AFSPDGKLLATGSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGECVRTLTGHT 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  312 GVIFALSWAPgDLNCIAGATSRNGAFIWDIQKGKIIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCII-RTVDGKLL 390
Cdd:cd00200    94 SYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSP-DGTFVASSSQDGTIKLwDLRTGKCV 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  391 HKYK-HPAAVFGCDWSQNNKDMIATGCeDKNIRVFYVATSsnQPLKVFSGHTARVFHVKWSPLREgILCSGSDDGSVRIW 469
Cdd:cd00200   171 ATLTgHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDLSTG--KCLGTLRGHENGVNSVAFSPDGY-LLASGSEDGTIRVW 246

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 568954847  470 DYTQDACVSTLNGHTAPVRGLMWNTEIPYlLISGSWDYTIKVWD 513
Cdd:cd00200   247 DLRTGECVQTLSGHTNSVTSLAWSPDGKR-LASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 306-557 6.00e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 161.35  E-value: 6.00e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  306 TSPGNEGVIFALSWAPgDLNCIAGATSRNGAFIWDIQKGKIIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCII-RT 384
Cdd:cd00200     4 TLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGH-TGPVRDVAASA-DGTYLASGSSDKTIRLwDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  385 VDGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFYVATssNQPLKVFSGHTARVFHVKWSPlREGILCSGSDD 463
Cdd:cd00200    81 ETGECVRTLTgHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVET--GKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  464 GSVRIWDYTQDACVSTLNGHTAPVRGLMWnTEIPYLLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPFtM 543
Cdd:cd00200   157 GTIKLWDLRTGKCVATLTGHTGEVNSVAF-SPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYL-L 234

                         250
                  ....*....|....
gi 568954847  544 ASCSRDSTVRLWSL 557
Cdd:cd00200   235 ASGSEDGTIRVWDL 248
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 347-557 4.61e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 147.48  E-value: 4.61e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  347 IQRFNEHGKnGIFYIAWsHKDSKRIATCSGDGFCII-RTVDGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVF 424
Cdd:cd00200     2 RRTLKGHTG-GVTCVAF-SPDGKLLATGSGDGTIKVwDLETGELLRTLKgHTGPVRDVAASADGT-YLASGSSDKTIRLW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  425 yvATSSNQPLKVFSGHTARVFHVKWSPLREgILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEiPYLLISGS 504
Cdd:cd00200    79 --DLETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSS 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568954847  505 WDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRpFTMASCSRDSTVRLWSL 557
Cdd:cd00200   155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDL 206
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 433-558 2.62e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.98  E-value: 2.62e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  433 PLKVFSGHTARVFHVKWSPLREgILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWnteIPY--LLISGSWDYTIK 510
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGK-LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAA---SADgtYLASGSSDKTIR 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 568954847  511 VWDTRGGVCLDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLWSLI 558
Cdd:cd00200    77 LWDLETGECVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVE 123
WD40 COG2319
WD40 repeat [General function prediction only];
320-557 2.94e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.94  E-value: 2.94e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  320 APGDLNCIAGATSRNGAFIWDIQKGKIIQRFNEHGkNGIFYIAWSHKDSKRIATCSGDGFCIIRTVDGKLLHKYK-HPAA 398
Cdd:COG2319     2 LSADGAALAAASADLALALLAAALGALLLLLLGLA-AAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLgHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  399 VFGCDWSQNNKdMIATGCEDKNIRVFYVATSsnQPLKVFSGHTARVFHVKWSPLREGILcSGSDDGSVRIWDYTQDACVS 478
Cdd:COG2319    81 VLSVAFSPDGR-LLASASADGTVRLWDLATG--LLLRTLTGHTGAVRSVAFSPDGKTLA-SGSADGTVRLWDLATGKLLR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  479 TLNGHTAPVRGLMWNteiP--YLLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHP-SRpfTMASCSRDSTVRLW 555
Cdd:COG2319   157 TLTGHSGAVTSVAFS---PdgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdGK--LLASGSADGTVRLW 231


                  ..
gi 568954847  556 SL 557
Cdd:COG2319   232 DL 233
WD40 COG2319
WD40 repeat [General function prediction only];
74-300 1.11e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.48  E-value: 1.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847   74 KLHAIMSEHKKTITAISWCPHNpDLFASSSTDNLVIIWNVAEQKVIAKLDNIKETPACLGWcwnTHD--AVAFVSQKGPL 151
Cdd:COG2319   195 KLLRTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF---SPDgrLLASGSADGTV 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  152 LIW---------TISGPDSGVSvhkeAHSFASDicifrwhtqkkGK-VAFGHIDGSISIFQPVSVQSPN--KNHYISSTS 219
Cdd:COG2319   271 RLWdlatgellrTLTGHSGGVN----SVAFSPD-----------GKlLASGSDDGTVRLWDLATGKLLRtlTGHTGAVRS 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  220 eaVpppnltqnqAFSlPPG-HVVCCFLDGGVGLYDMGAKKWdfLREL-GHVETIFDCKFKPDDpNVLATASFDGTIKVWD 297
Cdd:COG2319   336 --V---------AFS-PDGkTLASGSDDGTVRLWDLATGEL--LRTLtGHTGAVTSVAFSPDG-RTLASGSADGTVRLWD 400


                  ...
gi 568954847  298 INT 300
Cdd:COG2319   401 LAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 430-470 1.78e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 1.78e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 568954847    430 SNQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWD 470
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 404-557 1.06e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 56.25  E-value: 1.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  404 WSQNNKDMIATGCEDKNIRVFYVAtsSNQPLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQDACVSTLNGh 483
Cdd:PLN00181  540 WNSYIKSQVASSNFEGVVQVWDVA--RSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT- 616

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568954847  484 TAPVRGLMWNTEIPYLLISGSWDYTIKVWDTRG-GVCLDTVYDHGADVYGLTCHPSRpfTMASCSRDSTVRLWSL 557
Cdd:PLN00181  617 KANICCVQFPSESGRSLAFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFVDSS--TLVSSSTDNTLKLWDL 689
PTZ00420 PTZ00420
coronin; Provisional
 431-513 1.91e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 55.34  E-value: 1.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  431 NQPLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQD----------ACVstLNGHTAPVRGLMWNTEIPYLL 500
Cdd:PTZ00420   64 KPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNdesvkeikdpQCI--LKGHKKKISIIDWNPMNYYIM 141

                          90
                  ....*....|...
gi 568954847  501 ISGSWDYTIKVWD 513
Cdd:PTZ00420  142 CSSGFDSFVNIWD 154
WD40 pfam00400
WD domain, G-beta repeat;
431-470 6.09e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 6.09e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568954847   431 NQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWD 470
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 476-513 1.25e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 1.25e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 568954847    476 CVSTLNGHTAPVRGLMWNTEIPYLlISGSWDYTIKVWD 513
Cdd:smart00320    4 LLKTLKGHTGPVTSVAFSPDGKYL-ASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
476-513 7.72e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 7.72e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 568954847   476 CVSTLNGHTAPVRGLMWNTEIPYLlISGSWDYTIKVWD 513
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSPDGKLL-ASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 265-353 1.03e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.51  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  265 LGHVETIFDCKFKPDDPNVLATASFDGTIKVWDINT--LTAVYTSP-----GNEGVIFALSWAPGDLNCIAGATSRNGAF 337
Cdd:PTZ00421   72 LGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEegLTQNISDPivhlqGHTKKVGIVSFHPSAMNVLASAGADMVVN 151

                          90
                  ....*....|....*.
gi 568954847  338 IWDIQKGKIIQRFNEH 353
Cdd:PTZ00421  152 VWDVERGKAVEVIKCH 167
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 338-484 3.80e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.16  E-value: 3.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  338 IWDIQKGKIIQRFNEHGKNgIFYIAWSHKDSKRIATCSGDGFCIIRTVD-GKLLHKYKHPAAVFGCDWSQNNKDMIATGC 416
Cdd:PLN00181  559 VWDVARSQLVTEMKEHEKR-VWSIDYSSADPTLLASGSDDGSVKLWSINqGVSIGTIKTKANICCVQFPSESGRSLAFGS 637

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568954847  417 EDKNIrVFYVATSSNQPLKVFSGHTARVFHVKWspLREGILCSGSDDGSVRIWDYTQDAC------VSTLNGHT 484
Cdd:PLN00181  638 ADHKV-YYYDLRNPKLPLCTMIGHSKTVSYVRF--VDSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHT 708
PTZ00420 PTZ00420
coronin; Provisional
 410-470 5.17e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 47.25  E-value: 5.17e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568954847  410 DMIATGCEDKNIRVFYVATSSNQ------PLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWD 470
Cdd:PTZ00420   88 EILASGSEDLTIRVWEIPHNDESvkeikdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWD 154
PTZ00420 PTZ00420
coronin; Provisional
 464-580 5.54e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 47.25  E-value: 5.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  464 GSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTR-GGVCLDTVYD-------HGADVYGLTC 535
Cdd:PTZ00420   54 GAIRLENQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPhNDESVKEIKDpqcilkgHKKKISIIDW 133

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 568954847  536 HPSRPFTMASCSRDSTVRLWSLIPLITPLQINI---LADRSWDeVIGN 580
Cdd:PTZ00420  134 NPMNYYIMCSSGFDSFVNIWDIENEKRAFQINMpkkLSSLKWN-IKGN 180
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 266-297 1.06e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 1.06e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568954847    266 GHVETIFDCKFKPDDpNVLATASFDGTIKVWD 297
Cdd:smart00320   10 GHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 73-112 1.35e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 1.35e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 568954847     73 FKLHAIMSEHKKTITAISWCPHNpDLFASSSTDNLVIIWN 112
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 429-526 1.81e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.65  E-value: 1.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  429 SSNQPLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEiPYLLISGSWDYT 508
Cdd:PTZ00421  113 NISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLD-GSLLCTTSKDKK 191

                          90
                  ....*....|....*...
gi 568954847  509 IKVWDTRGGVCLDTVYDH 526
Cdd:PTZ00421  192 LNIIDPRDGTIVSSVEAH 209
WD40 pfam00400
WD domain, G-beta repeat;
266-297 2.79e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 2.79e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568954847   266 GHVETIFDCKFKPDDpNVLATASFDGTIKVWD 297
Cdd:pfam00400    9 GHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
517-556 3.01e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 3.01e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568954847   517 GVCLDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLWS 556
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 517-556 3.92e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 3.92e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 568954847    517 GVCLDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLWS 556
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 429-554 4.02e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.50  E-value: 4.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  429 SSNQPLKVfsGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQDACVST-------LNGHTAPVRGLMWNTEIPYLLI 501
Cdd:PTZ00421   65 ASNPPILL--GQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNisdpivhLQGHTKKVGIVSFHPSAMNVLA 142

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568954847  502 SGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHpSRPFTMASCSRDSTVRL 554
Cdd:PTZ00421  143 SAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWN-LDGSLLCTTSKDKKLNI 194
PTZ00421 PTZ00421
coronin; Provisional
 266-353 1.37e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.57  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954847  266 GHVETIFDCKFKPDDPNVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSW-APGDLNCiagATSRNGAF-IWDIQK 343
Cdd:PTZ00421  123 GHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWnLDGSLLC---TTSKDKKLnIIDPRD 199

                          90
                  ....*....|
gi 568954847  344 GKIIQRFNEH 353
Cdd:PTZ00421  200 GTIVSSVEAH 209
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 386-424 1.52e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.52e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 568954847    386 DGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVF 424
Cdd:smart00320    1 SGELLKTLKgHTGPVTSVAFSPDGK-YLASGSDDGTIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 489-557 2.36e-03

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.00  E-value: 2.36e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568954847  489 GLMWNTEIPYLLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSL 557
Cdd:PLN00181  537 GICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSI 605
PTZ00420 PTZ00420
coronin; Provisional
 59-117 2.44e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.86  E-value: 2.44e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568954847   59 LAIYIYQLDHR---YNEFK-LHAIMSEHKKTITAISWCPHNPDLFASSSTDNLVIIWNVAEQK 117
Cdd:PTZ00420   97 LTIRVWEIPHNdesVKEIKdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEK 159
WD40 pfam00400
WD domain, G-beta repeat;
73-112 3.11e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 3.11e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568954847    73 FKLHAIMSEHKKTITAISWCPHNpDLFASSSTDNLVIIWN 112
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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