|
Name |
Accession |
Description |
Interval |
E-value |
| APC_basic |
pfam05956 |
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ... |
1763-2095 |
6.36e-97 |
|
APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.
:
Pssm-ID: 428690 [Multi-domain] Cd Length: 336 Bit Score: 316.82 E-value: 6.36e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1763 TMLRGRTVIYSAGpASRTQSKGISGPCTTPKKTgtsgttqpETVTKAPSPEQQRSRSLHRPGKISELAALRHPPRSATPP 1842
Cdd:pfam05956 1 VVFRGRTVIYMPG-VKESQPSTSPPPKKTPPKT--------DAPAKNPNLGQQRSRSLHRLGKPSELADLSPPKRSATPP 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1843 ARLAKTPSSSSSQTSPASQPLPRRSPLATPTGGPLPGPGGS------LVPKSPARALLAKQ--HKTQKSPVRIPFMQRPA 1914
Cdd:pfam05956 72 ARISKAPSSGSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRnklsplPKTKSPARASTKKSgsHKTQKSPVRIPFMQTPT 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1915 R-----RVPPPLARPSPEPgsRGRAGAEGTPGARGSRLGLVRMASARSSGSESSDRSgFRRQLTFIKESPGLLRRRRSEL 1989
Cdd:pfam05956 152 KqtglpRNPSPLVTNQPEP--RSESASKGLRSLPGKRLDLVRMSSARSSGSESDRSG-FLRQLTFIKESPSLLLRRRLEL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1990 SSADSTASTSQAASPRRGRPALPAVFLCSSRCDELRVSPRQPLAA--QRSPQAKPGLAPRAPRRTSSESPSRLPVRASPG 2067
Cdd:pfam05956 229 SASESLSPSSQPASPRRSRPGLPAVFLCSSRCQELKGWRKQPPNPnsRAEPSDRPLTRRRPPRRTSSESPSRLPVRNGTW 308
|
330 340
....*....|....*....|....*...
gi 568967560 2068 RPETVKRYASLPHISVSRRSDSAVSVPT 2095
Cdd:pfam05956 309 KRETFKRYSSLPHINVWRRTGSSSSILS 336
|
|
| APC_rep |
pfam18797 |
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ... |
357-430 |
1.60e-36 |
|
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.
:
Pssm-ID: 465870 Cd Length: 74 Bit Score: 133.06 E-value: 1.60e-36
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568967560 357 SQPDQGLARKEMRVLHVLEQIRAYCETCWDWLQARDSGTESGTGDTPVPIEPQICQATCAVMKLSFDEEYRRAM 430
Cdd:pfam18797 1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
|
|
| APC_N_CC |
pfam16689 |
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil ... |
6-57 |
5.38e-26 |
|
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.
:
Pssm-ID: 435517 Cd Length: 52 Bit Score: 102.37 E-value: 5.38e-26
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 568967560 6 ASYEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKL 57
Cdd:pfam16689 1 ASYDQLLRQVEALKLENTTLRQELRDNSSHLSKLETEASNMKEVLKHLQGSI 52
|
|
| Suppressor_APC |
pfam11414 |
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ... |
124-205 |
7.19e-20 |
|
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.
:
Pssm-ID: 463275 Cd Length: 82 Bit Score: 85.77 E-value: 7.19e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 124 SRATIRLLEELDQERCFLLSEIEKEEKEKLWYYSQLQGLSKRLDELPHVDTQFSMQMDLIRQQLEFEAQHIRSLMEERFG 203
Cdd:pfam11414 1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGTYFDYGSDAQQERLEFLLARIQEVNRCLGG 80
|
..
gi 568967560 204 TS 205
Cdd:pfam11414 81 LI 82
|
|
| Arm_APC_u3 super family |
cl25003 |
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ... |
696-942 |
5.39e-17 |
|
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
The actual alignment was detected with superfamily member pfam16629:
Pssm-ID: 435476 Cd Length: 293 Bit Score: 83.87 E-value: 5.39e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 696 HRPAKYQAAAMaVSPGTCVPSLYVRKQRALEAELDTRHLVHALGHLEKQSlPEAETTSKKplpplRHLDGLVQDYASDSG 775
Cdd:pfam16629 1 NRPAKYKDANI-MSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLS-PKASHRNKQ-----RHKQNVYSEYVLDSG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 776 CFDDddapsLAAAATTAEPASPAVMSMFLGGPFLQGQAlARTPPARQGGLEAEK-----------------EAGGEAAVA 838
Cdd:pfam16629 74 RHDD-----SVCRSDNFNTGNVTVLSPYLNTTVLPSSS-SRDSRGNAESSRSEKdrsldrergaglsnfhpATENSGNSS 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 839 AKAKAKLALAVARIDRLVEDISALHTSSDDSFSLSSGDP---GQEAPREGRAQSCSPCRGTEG-GRREAGSRAHPLLRLK 914
Cdd:pfam16629 148 KRIGMQISTTAAQIAKVMEEVSSMHISQEDRSSGSTSDMhcmQDDRNSIRRSSTAHPHSNVYSfNKSESSNRPCPMPYMK 227
|
250 260
....*....|....*....|....*...
gi 568967560 915 AAHTSLSNDSLNSGSTSDGYCTREHMTP 942
Cdd:pfam16629 228 MEYKRASNDSLNSVSSSDGYGKRGQMKP 255
|
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
614-653 |
1.42e-06 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
:
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 46.68 E-value: 1.42e-06
10 20 30 40
....*....|....*....|....*....|....*....|
gi 568967560 614 EDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSA 653
Cdd:pfam00514 2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
|
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
1511-1950 |
7.22e-05 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 48.40 E-value: 7.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1511 PPPRRASAIPRALKREKPAGRKETP---SRAAQPATLPVRAQPRLIVDETPPcysltssaSSLSEPEAPEQPANHARGPE 1587
Cdd:PHA03247 2556 PPAAPPAAPDRSVPPPRPAPRPSEPavtSRARRPDAPPQSARPRAPVDDRGD--------PRGPAPPSPLPPDTHAPDPP 2627
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1588 QgskqdSSPSPRAEEELLQRCISLAMPRRRTQVP-GSRRRKPRALRSDIRPTEITQKCQ--EEVAGSDPASDLDSVEWQA 1664
Cdd:PHA03247 2628 P-----PSPSPAANEPDPHPPPTVPPPERPRDDPaPGRVSRPRRARRLGRAAQASSPPQrpRRRAARPTVGSLTSLADPP 2702
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1665 IQEGAnsivtwlhQAAAKASLEASSESDSLLSLVSGVSAGSTLQPSKLRKGRKPAAEAGGAWRPEKRGTTSTKINGSPRL 1744
Cdd:PHA03247 2703 PPPPT--------PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAA 2774
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1745 PNGPEKAKGTQKMMAGESTMLRGRTVIYSAGPASRTQSKGISGPCTTPKKTGTSGTTQPETVTKAPSPEQQRSRSLHRPG 1824
Cdd:PHA03247 2775 PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGG 2854
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1825 KISELAALRHPPRSATPPARLAktpsssssqtsPASQPLPRRSPLATPTGGPLPGPGGSLVPKSPARALLAKQHKTQKSP 1904
Cdd:PHA03247 2855 SVAPGGDVRRRPPSRSPAAKPA-----------APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQP 2923
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 568967560 1905 VRIPFMQRPARrvPPPLARPSPEPGSRGRAGAEGTPGARGSRLGLV 1950
Cdd:PHA03247 2924 PPPPQPQPPPP--PPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGAL 2967
|
|
| PTZ00449 super family |
cl33186 |
104 kDa microneme/rhoptry antigen; Provisional |
2005-2202 |
3.08e-04 |
|
104 kDa microneme/rhoptry antigen; Provisional
The actual alignment was detected with superfamily member PTZ00449:
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 46.22 E-value: 3.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 2005 RRGRPALPAVFLC--SSRCDELRVSPRQPLAAQRSPQAKPGLAPRAPRrtSSESPSRLPVRASPGRPETV------KRYA 2076
Cdd:PTZ00449 608 RPKSPKLPELLDIpkSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIK--SPKPPKSPKPPFDPKFKEKFyddyldAAAK 685
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 2077 SLPHISVSRRSDSAVSVPTTQANATRRGSDGEARPLPRVAP--PGTTWRRIKDEDVPHILRSTLPATALPLRVSSPEdSP 2154
Cdd:PTZ00449 686 SKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLPrdEEFPFEPIGDPDAEQPDDIEFFTPPEEERTFFHE-TP 764
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 568967560 2155 AGTPQRKTSDAVVQTEDVaTSKTNSSTSPSLESRDP----PQAPASGPVAPQ 2202
Cdd:PTZ00449 765 ADTPLPDILAEEFKEEDI-HAETGEPDEAMKRPDSPseheDKPPGDHPSLPK 815
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1376-1398 |
6.39e-04 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
:
Pssm-ID: 461781 Cd Length: 24 Bit Score: 38.90 E-value: 6.39e-04
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
655-695 |
3.11e-03 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
:
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 37.43 E-value: 3.11e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 568967560 655 SPRDQELLWDLGAVGMLRNLVHSKHKMIAMGSAAALRNLLA 695
Cdd:pfam00514 1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1253-1274 |
3.52e-03 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
:
Pssm-ID: 461781 Cd Length: 24 Bit Score: 36.59 E-value: 3.52e-03
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1141-1164 |
5.65e-03 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
:
Pssm-ID: 461781 Cd Length: 24 Bit Score: 36.20 E-value: 5.65e-03
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
1291-1628 |
6.12e-03 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 42.23 E-value: 6.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1291 PPACPERAVGGGGHRRRDEAASRLDGPAPAGSRARSATDKeleALRECLG-----AAMPARLRKVASALVPGRRSLPVPv 1365
Cdd:PHA03247 2647 PPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRR---AARPTVGsltslADPPPPPPTPEPAPHALVSATPLP- 2722
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1366 ymLVPAPARGDDSGTDSAEGTPVNFSSAASLSDETlQGPSRDKPAGPGDRQKPTGRAAPArQTRSHRPKAAGAGKSTEHT 1445
Cdd:PHA03247 2723 --PGPAAARQASPALPAAPAPPAVPAGPATPGGPA-RPARPPTTAGPPAPAPPAAPAAGP-PRRLTRPAVASLSESRESL 2798
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1446 RGPcRNRAGLELPLSRPQSARSNRDSSCQTRTRGDGALQS--------LCLTTPTEEAVYCFYD-SDEEPPATAPPPRRA 1516
Cdd:PHA03247 2799 PSP-WDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTapppppgpPPPSLPLGGSVAPGGDvRRRPPSRSPAAKPAA 2877
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1517 SAIPRALKREKPAgrketPSRAAQPATLPVRAQPRLIVDETPPCYSLTSSASSLSEPEAPEQPANHAR---GPEQGSKQD 1593
Cdd:PHA03247 2878 PARPPVRRLARPA-----VSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQpplAPTTDPAGA 2952
|
330 340 350
....*....|....*....|....*....|....*
gi 568967560 1594 SSPSPRAEEELLQRCISLAMPRRRTQVPGSRRRKP 1628
Cdd:PHA03247 2953 GEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSRE 2987
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| APC_basic |
pfam05956 |
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ... |
1763-2095 |
6.36e-97 |
|
APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.
Pssm-ID: 428690 [Multi-domain] Cd Length: 336 Bit Score: 316.82 E-value: 6.36e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1763 TMLRGRTVIYSAGpASRTQSKGISGPCTTPKKTgtsgttqpETVTKAPSPEQQRSRSLHRPGKISELAALRHPPRSATPP 1842
Cdd:pfam05956 1 VVFRGRTVIYMPG-VKESQPSTSPPPKKTPPKT--------DAPAKNPNLGQQRSRSLHRLGKPSELADLSPPKRSATPP 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1843 ARLAKTPSSSSSQTSPASQPLPRRSPLATPTGGPLPGPGGS------LVPKSPARALLAKQ--HKTQKSPVRIPFMQRPA 1914
Cdd:pfam05956 72 ARISKAPSSGSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRnklsplPKTKSPARASTKKSgsHKTQKSPVRIPFMQTPT 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1915 R-----RVPPPLARPSPEPgsRGRAGAEGTPGARGSRLGLVRMASARSSGSESSDRSgFRRQLTFIKESPGLLRRRRSEL 1989
Cdd:pfam05956 152 KqtglpRNPSPLVTNQPEP--RSESASKGLRSLPGKRLDLVRMSSARSSGSESDRSG-FLRQLTFIKESPSLLLRRRLEL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1990 SSADSTASTSQAASPRRGRPALPAVFLCSSRCDELRVSPRQPLAA--QRSPQAKPGLAPRAPRRTSSESPSRLPVRASPG 2067
Cdd:pfam05956 229 SASESLSPSSQPASPRRSRPGLPAVFLCSSRCQELKGWRKQPPNPnsRAEPSDRPLTRRRPPRRTSSESPSRLPVRNGTW 308
|
330 340
....*....|....*....|....*...
gi 568967560 2068 RPETVKRYASLPHISVSRRSDSAVSVPT 2095
Cdd:pfam05956 309 KRETFKRYSSLPHINVWRRTGSSSSILS 336
|
|
| APC_rep |
pfam18797 |
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ... |
357-430 |
1.60e-36 |
|
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.
Pssm-ID: 465870 Cd Length: 74 Bit Score: 133.06 E-value: 1.60e-36
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568967560 357 SQPDQGLARKEMRVLHVLEQIRAYCETCWDWLQARDSGTESGTGDTPVPIEPQICQATCAVMKLSFDEEYRRAM 430
Cdd:pfam18797 1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
|
|
| APC_N_CC |
pfam16689 |
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil ... |
6-57 |
5.38e-26 |
|
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.
Pssm-ID: 435517 Cd Length: 52 Bit Score: 102.37 E-value: 5.38e-26
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 568967560 6 ASYEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKL 57
Cdd:pfam16689 1 ASYDQLLRQVEALKLENTTLRQELRDNSSHLSKLETEASNMKEVLKHLQGSI 52
|
|
| Suppressor_APC |
pfam11414 |
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ... |
124-205 |
7.19e-20 |
|
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.
Pssm-ID: 463275 Cd Length: 82 Bit Score: 85.77 E-value: 7.19e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 124 SRATIRLLEELDQERCFLLSEIEKEEKEKLWYYSQLQGLSKRLDELPHVDTQFSMQMDLIRQQLEFEAQHIRSLMEERFG 203
Cdd:pfam11414 1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGTYFDYGSDAQQERLEFLLARIQEVNRCLGG 80
|
..
gi 568967560 204 TS 205
Cdd:pfam11414 81 LI 82
|
|
| Arm_APC_u3 |
pfam16629 |
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ... |
696-942 |
5.39e-17 |
|
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
Pssm-ID: 435476 Cd Length: 293 Bit Score: 83.87 E-value: 5.39e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 696 HRPAKYQAAAMaVSPGTCVPSLYVRKQRALEAELDTRHLVHALGHLEKQSlPEAETTSKKplpplRHLDGLVQDYASDSG 775
Cdd:pfam16629 1 NRPAKYKDANI-MSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLS-PKASHRNKQ-----RHKQNVYSEYVLDSG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 776 CFDDddapsLAAAATTAEPASPAVMSMFLGGPFLQGQAlARTPPARQGGLEAEK-----------------EAGGEAAVA 838
Cdd:pfam16629 74 RHDD-----SVCRSDNFNTGNVTVLSPYLNTTVLPSSS-SRDSRGNAESSRSEKdrsldrergaglsnfhpATENSGNSS 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 839 AKAKAKLALAVARIDRLVEDISALHTSSDDSFSLSSGDP---GQEAPREGRAQSCSPCRGTEG-GRREAGSRAHPLLRLK 914
Cdd:pfam16629 148 KRIGMQISTTAAQIAKVMEEVSSMHISQEDRSSGSTSDMhcmQDDRNSIRRSSTAHPHSNVYSfNKSESSNRPCPMPYMK 227
|
250 260
....*....|....*....|....*...
gi 568967560 915 AAHTSLSNDSLNSGSTSDGYCTREHMTP 942
Cdd:pfam16629 228 MEYKRASNDSLNSVSSSDGYGKRGQMKP 255
|
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
614-653 |
1.42e-06 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 46.68 E-value: 1.42e-06
10 20 30 40
....*....|....*....|....*....|....*....|
gi 568967560 614 EDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSA 653
Cdd:pfam00514 2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
|
|
| ARM |
smart00185 |
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
613-653 |
2.16e-06 |
|
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.
Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 46.27 E-value: 2.16e-06
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 568967560 613 REDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSA 653
Cdd:smart00185 1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
1775-1928 |
2.17e-05 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 50.07 E-value: 2.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1775 GPASRTQSKGISGPCT---TPKKTGTSGTTQPETVTKAPSPEQQrsrslHRPGKISELAALRHPPRSATPPARlaKTPSS 1851
Cdd:PTZ00449 523 APGDKEGEEGEHEDSKesdEPKEGGKPGETKEGEVGKKPGPAKE-----HKPSKIPTLSKKPEFPKDPKHPKD--PEEPK 595
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568967560 1852 SSSQTSPASQPLPRRSPlatptggplPGPGGSLVPKSPARALLAKQHKTQKSPVRIPFMQRPARRVPPPLARP--SPEP 1928
Cdd:PTZ00449 596 KPKRPRSAQRPTRPKSP---------KLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPpkSPKP 665
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1511-1950 |
7.22e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 48.40 E-value: 7.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1511 PPPRRASAIPRALKREKPAGRKETP---SRAAQPATLPVRAQPRLIVDETPPcysltssaSSLSEPEAPEQPANHARGPE 1587
Cdd:PHA03247 2556 PPAAPPAAPDRSVPPPRPAPRPSEPavtSRARRPDAPPQSARPRAPVDDRGD--------PRGPAPPSPLPPDTHAPDPP 2627
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1588 QgskqdSSPSPRAEEELLQRCISLAMPRRRTQVP-GSRRRKPRALRSDIRPTEITQKCQ--EEVAGSDPASDLDSVEWQA 1664
Cdd:PHA03247 2628 P-----PSPSPAANEPDPHPPPTVPPPERPRDDPaPGRVSRPRRARRLGRAAQASSPPQrpRRRAARPTVGSLTSLADPP 2702
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1665 IQEGAnsivtwlhQAAAKASLEASSESDSLLSLVSGVSAGSTLQPSKLRKGRKPAAEAGGAWRPEKRGTTSTKINGSPRL 1744
Cdd:PHA03247 2703 PPPPT--------PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAA 2774
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1745 PNGPEKAKGTQKMMAGESTMLRGRTVIYSAGPASRTQSKGISGPCTTPKKTGTSGTTQPETVTKAPSPEQQRSRSLHRPG 1824
Cdd:PHA03247 2775 PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGG 2854
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1825 KISELAALRHPPRSATPPARLAktpsssssqtsPASQPLPRRSPLATPTGGPLPGPGGSLVPKSPARALLAKQHKTQKSP 1904
Cdd:PHA03247 2855 SVAPGGDVRRRPPSRSPAAKPA-----------APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQP 2923
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 568967560 1905 VRIPFMQRPARrvPPPLARPSPEPGSRGRAGAEGTPGARGSRLGLV 1950
Cdd:PHA03247 2924 PPPPQPQPPPP--PPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGAL 2967
|
|
| SAMP |
pfam05924 |
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1597-1618 |
8.93e-05 |
|
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.
Pssm-ID: 461782 Cd Length: 22 Bit Score: 41.42 E-value: 8.93e-05
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
2005-2202 |
3.08e-04 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 46.22 E-value: 3.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 2005 RRGRPALPAVFLC--SSRCDELRVSPRQPLAAQRSPQAKPGLAPRAPRrtSSESPSRLPVRASPGRPETV------KRYA 2076
Cdd:PTZ00449 608 RPKSPKLPELLDIpkSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIK--SPKPPKSPKPPFDPKFKEKFyddyldAAAK 685
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 2077 SLPHISVSRRSDSAVSVPTTQANATRRGSDGEARPLPRVAP--PGTTWRRIKDEDVPHILRSTLPATALPLRVSSPEdSP 2154
Cdd:PTZ00449 686 SKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLPrdEEFPFEPIGDPDAEQPDDIEFFTPPEEERTFFHE-TP 764
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 568967560 2155 AGTPQRKTSDAVVQTEDVaTSKTNSSTSPSLESRDP----PQAPASGPVAPQ 2202
Cdd:PTZ00449 765 ADTPLPDILAEEFKEEDI-HAETGEPDEAMKRPDSPseheDKPPGDHPSLPK 815
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1376-1398 |
6.39e-04 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Pssm-ID: 461781 Cd Length: 24 Bit Score: 38.90 E-value: 6.39e-04
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
655-695 |
3.11e-03 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 37.43 E-value: 3.11e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 568967560 655 SPRDQELLWDLGAVGMLRNLVHSKHKMIAMGSAAALRNLLA 695
Cdd:pfam00514 1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1253-1274 |
3.52e-03 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Pssm-ID: 461781 Cd Length: 24 Bit Score: 36.59 E-value: 3.52e-03
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
7-245 |
3.87e-03 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 42.20 E-value: 3.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 7 SYEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLEQEARVL--VSSGQTEVLEQLKALQTDIS 84
Cdd:COG4372 32 QLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLqaAQAELAQAQEELESLQEEAE 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 85 SLynlkfhapalgpepaartpegspvhgsgpskdsfgelsRATIrllEELDQERCFLlseiekeekeklwyYSQLQGLSK 164
Cdd:COG4372 112 EL--------------------------------------QEEL---EELQKERQDL--------------EQQRKQLEA 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 165 RLDELPHVDTQFSMQMDLIRQQLEFEAQHIRSLmeerfgtsdEMVQRAQIRASRLEQIDKELLEAQDRVQQTEPQALLAV 244
Cdd:COG4372 137 QIAELQSEIAEREEELKELEEQLESLQEELAAL---------EQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEK 207
|
.
gi 568967560 245 K 245
Cdd:COG4372 208 L 208
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1141-1164 |
5.65e-03 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Pssm-ID: 461781 Cd Length: 24 Bit Score: 36.20 E-value: 5.65e-03
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1291-1628 |
6.12e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 42.23 E-value: 6.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1291 PPACPERAVGGGGHRRRDEAASRLDGPAPAGSRARSATDKeleALRECLG-----AAMPARLRKVASALVPGRRSLPVPv 1365
Cdd:PHA03247 2647 PPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRR---AARPTVGsltslADPPPPPPTPEPAPHALVSATPLP- 2722
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1366 ymLVPAPARGDDSGTDSAEGTPVNFSSAASLSDETlQGPSRDKPAGPGDRQKPTGRAAPArQTRSHRPKAAGAGKSTEHT 1445
Cdd:PHA03247 2723 --PGPAAARQASPALPAAPAPPAVPAGPATPGGPA-RPARPPTTAGPPAPAPPAAPAAGP-PRRLTRPAVASLSESRESL 2798
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1446 RGPcRNRAGLELPLSRPQSARSNRDSSCQTRTRGDGALQS--------LCLTTPTEEAVYCFYD-SDEEPPATAPPPRRA 1516
Cdd:PHA03247 2799 PSP-WDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTapppppgpPPPSLPLGGSVAPGGDvRRRPPSRSPAAKPAA 2877
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1517 SAIPRALKREKPAgrketPSRAAQPATLPVRAQPRLIVDETPPCYSLTSSASSLSEPEAPEQPANHAR---GPEQGSKQD 1593
Cdd:PHA03247 2878 PARPPVRRLARPA-----VSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQpplAPTTDPAGA 2952
|
330 340 350
....*....|....*....|....*....|....*
gi 568967560 1594 SSPSPRAEEELLQRCISLAMPRRRTQVPGSRRRKP 1628
Cdd:PHA03247 2953 GEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSRE 2987
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| APC_basic |
pfam05956 |
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ... |
1763-2095 |
6.36e-97 |
|
APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.
Pssm-ID: 428690 [Multi-domain] Cd Length: 336 Bit Score: 316.82 E-value: 6.36e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1763 TMLRGRTVIYSAGpASRTQSKGISGPCTTPKKTgtsgttqpETVTKAPSPEQQRSRSLHRPGKISELAALRHPPRSATPP 1842
Cdd:pfam05956 1 VVFRGRTVIYMPG-VKESQPSTSPPPKKTPPKT--------DAPAKNPNLGQQRSRSLHRLGKPSELADLSPPKRSATPP 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1843 ARLAKTPSSSSSQTSPASQPLPRRSPLATPTGGPLPGPGGS------LVPKSPARALLAKQ--HKTQKSPVRIPFMQRPA 1914
Cdd:pfam05956 72 ARISKAPSSGSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRnklsplPKTKSPARASTKKSgsHKTQKSPVRIPFMQTPT 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1915 R-----RVPPPLARPSPEPgsRGRAGAEGTPGARGSRLGLVRMASARSSGSESSDRSgFRRQLTFIKESPGLLRRRRSEL 1989
Cdd:pfam05956 152 KqtglpRNPSPLVTNQPEP--RSESASKGLRSLPGKRLDLVRMSSARSSGSESDRSG-FLRQLTFIKESPSLLLRRRLEL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1990 SSADSTASTSQAASPRRGRPALPAVFLCSSRCDELRVSPRQPLAA--QRSPQAKPGLAPRAPRRTSSESPSRLPVRASPG 2067
Cdd:pfam05956 229 SASESLSPSSQPASPRRSRPGLPAVFLCSSRCQELKGWRKQPPNPnsRAEPSDRPLTRRRPPRRTSSESPSRLPVRNGTW 308
|
330 340
....*....|....*....|....*...
gi 568967560 2068 RPETVKRYASLPHISVSRRSDSAVSVPT 2095
Cdd:pfam05956 309 KRETFKRYSSLPHINVWRRTGSSSSILS 336
|
|
| APC_rep |
pfam18797 |
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ... |
357-430 |
1.60e-36 |
|
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.
Pssm-ID: 465870 Cd Length: 74 Bit Score: 133.06 E-value: 1.60e-36
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568967560 357 SQPDQGLARKEMRVLHVLEQIRAYCETCWDWLQARDSGTESGTGDTPVPIEPQICQATCAVMKLSFDEEYRRAM 430
Cdd:pfam18797 1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
|
|
| APC_N_CC |
pfam16689 |
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil ... |
6-57 |
5.38e-26 |
|
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.
Pssm-ID: 435517 Cd Length: 52 Bit Score: 102.37 E-value: 5.38e-26
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 568967560 6 ASYEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKL 57
Cdd:pfam16689 1 ASYDQLLRQVEALKLENTTLRQELRDNSSHLSKLETEASNMKEVLKHLQGSI 52
|
|
| Suppressor_APC |
pfam11414 |
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ... |
124-205 |
7.19e-20 |
|
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.
Pssm-ID: 463275 Cd Length: 82 Bit Score: 85.77 E-value: 7.19e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 124 SRATIRLLEELDQERCFLLSEIEKEEKEKLWYYSQLQGLSKRLDELPHVDTQFSMQMDLIRQQLEFEAQHIRSLMEERFG 203
Cdd:pfam11414 1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGTYFDYGSDAQQERLEFLLARIQEVNRCLGG 80
|
..
gi 568967560 204 TS 205
Cdd:pfam11414 81 LI 82
|
|
| Arm_APC_u3 |
pfam16629 |
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ... |
696-942 |
5.39e-17 |
|
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
Pssm-ID: 435476 Cd Length: 293 Bit Score: 83.87 E-value: 5.39e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 696 HRPAKYQAAAMaVSPGTCVPSLYVRKQRALEAELDTRHLVHALGHLEKQSlPEAETTSKKplpplRHLDGLVQDYASDSG 775
Cdd:pfam16629 1 NRPAKYKDANI-MSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLS-PKASHRNKQ-----RHKQNVYSEYVLDSG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 776 CFDDddapsLAAAATTAEPASPAVMSMFLGGPFLQGQAlARTPPARQGGLEAEK-----------------EAGGEAAVA 838
Cdd:pfam16629 74 RHDD-----SVCRSDNFNTGNVTVLSPYLNTTVLPSSS-SRDSRGNAESSRSEKdrsldrergaglsnfhpATENSGNSS 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 839 AKAKAKLALAVARIDRLVEDISALHTSSDDSFSLSSGDP---GQEAPREGRAQSCSPCRGTEG-GRREAGSRAHPLLRLK 914
Cdd:pfam16629 148 KRIGMQISTTAAQIAKVMEEVSSMHISQEDRSSGSTSDMhcmQDDRNSIRRSSTAHPHSNVYSfNKSESSNRPCPMPYMK 227
|
250 260
....*....|....*....|....*...
gi 568967560 915 AAHTSLSNDSLNSGSTSDGYCTREHMTP 942
Cdd:pfam16629 228 MEYKRASNDSLNSVSSSDGYGKRGQMKP 255
|
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
614-653 |
1.42e-06 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 46.68 E-value: 1.42e-06
10 20 30 40
....*....|....*....|....*....|....*....|
gi 568967560 614 EDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSA 653
Cdd:pfam00514 2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
|
|
| ARM |
smart00185 |
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
613-653 |
2.16e-06 |
|
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.
Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 46.27 E-value: 2.16e-06
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 568967560 613 REDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSA 653
Cdd:smart00185 1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
1775-1928 |
2.17e-05 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 50.07 E-value: 2.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1775 GPASRTQSKGISGPCT---TPKKTGTSGTTQPETVTKAPSPEQQrsrslHRPGKISELAALRHPPRSATPPARlaKTPSS 1851
Cdd:PTZ00449 523 APGDKEGEEGEHEDSKesdEPKEGGKPGETKEGEVGKKPGPAKE-----HKPSKIPTLSKKPEFPKDPKHPKD--PEEPK 595
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568967560 1852 SSSQTSPASQPLPRRSPlatptggplPGPGGSLVPKSPARALLAKQHKTQKSPVRIPFMQRPARRVPPPLARP--SPEP 1928
Cdd:PTZ00449 596 KPKRPRSAQRPTRPKSP---------KLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPpkSPKP 665
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1798-2280 |
4.12e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.17 E-value: 4.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1798 SGTTQPETVTKAPSPEQQRSRSLHRPGkiselaalrhpPRSATPPARLAKTPSSSSSQTSPASQPL-PRRSPLATPTGGP 1876
Cdd:PHA03247 2548 AGDPPPPLPPAAPPAAPDRSVPPPRPA-----------PRPSEPAVTSRARRPDAPPQSARPRAPVdDRGDPRGPAPPSP 2616
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1877 LPGPGGSLVPKSPARALLAKQhKTQKSPVRIPFMQRPARRVPPPLARPSPEPGSRGRAGAEGTPGARGSRLGL-----VR 1951
Cdd:PHA03247 2617 LPPDTHAPDPPPPSPSPAANE-PDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAArptvgSL 2695
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1952 MASARSSGSESSDRSGFRRQLTFIKESPGLLRRRRSELSSADSTASTSQAASP-------RRGRPALPAvflcssrcdel 2024
Cdd:PHA03247 2696 TSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPatpggpaRPARPPTTA----------- 2764
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 2025 rvSPRQPLAAQRSPQAKPGLAPRAPRRTSSESPSRLPVRASPGRPETVKRYASLPHISVSRRSDSAVSVPTTQANATRRG 2104
Cdd:PHA03247 2765 --GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPP 2842
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 2105 SDGEARPLP---RVAPPGTTWRR-------IKDEDVPHILRSTLPATALPLRVSSPEDSPAGTPQRKTSDAVVQTEDVAT 2174
Cdd:PHA03247 2843 PGPPPPSLPlggSVAPGGDVRRRppsrspaAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQ 2922
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 2175 SKTNSSTSPSLESRDPPQAPASGPVAPQGSDVDGPVLTKPPASAPFPHEgLSAVIAGFPTSRHGSPSRAARVPPFNYVPS 2254
Cdd:PHA03247 2923 PPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGR-VAVPRFRVPQPAPSREAPASSTPPLTGHSL 3001
|
490 500
....*....|....*....|....*.
gi 568967560 2255 PmAAATMASDSAVEKAPVSSPASLLE 2280
Cdd:PHA03247 3002 S-RVSSWASSLALHEETDPPPVSLKQ 3026
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1511-1950 |
7.22e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 48.40 E-value: 7.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1511 PPPRRASAIPRALKREKPAGRKETP---SRAAQPATLPVRAQPRLIVDETPPcysltssaSSLSEPEAPEQPANHARGPE 1587
Cdd:PHA03247 2556 PPAAPPAAPDRSVPPPRPAPRPSEPavtSRARRPDAPPQSARPRAPVDDRGD--------PRGPAPPSPLPPDTHAPDPP 2627
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1588 QgskqdSSPSPRAEEELLQRCISLAMPRRRTQVP-GSRRRKPRALRSDIRPTEITQKCQ--EEVAGSDPASDLDSVEWQA 1664
Cdd:PHA03247 2628 P-----PSPSPAANEPDPHPPPTVPPPERPRDDPaPGRVSRPRRARRLGRAAQASSPPQrpRRRAARPTVGSLTSLADPP 2702
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1665 IQEGAnsivtwlhQAAAKASLEASSESDSLLSLVSGVSAGSTLQPSKLRKGRKPAAEAGGAWRPEKRGTTSTKINGSPRL 1744
Cdd:PHA03247 2703 PPPPT--------PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAA 2774
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1745 PNGPEKAKGTQKMMAGESTMLRGRTVIYSAGPASRTQSKGISGPCTTPKKTGTSGTTQPETVTKAPSPEQQRSRSLHRPG 1824
Cdd:PHA03247 2775 PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGG 2854
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1825 KISELAALRHPPRSATPPARLAktpsssssqtsPASQPLPRRSPLATPTGGPLPGPGGSLVPKSPARALLAKQHKTQKSP 1904
Cdd:PHA03247 2855 SVAPGGDVRRRPPSRSPAAKPA-----------APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQP 2923
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 568967560 1905 VRIPFMQRPARrvPPPLARPSPEPGSRGRAGAEGTPGARGSRLGLV 1950
Cdd:PHA03247 2924 PPPPQPQPPPP--PPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGAL 2967
|
|
| SAMP |
pfam05924 |
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1597-1618 |
8.93e-05 |
|
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.
Pssm-ID: 461782 Cd Length: 22 Bit Score: 41.42 E-value: 8.93e-05
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
2005-2202 |
3.08e-04 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 46.22 E-value: 3.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 2005 RRGRPALPAVFLC--SSRCDELRVSPRQPLAAQRSPQAKPGLAPRAPRrtSSESPSRLPVRASPGRPETV------KRYA 2076
Cdd:PTZ00449 608 RPKSPKLPELLDIpkSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIK--SPKPPKSPKPPFDPKFKEKFyddyldAAAK 685
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 2077 SLPHISVSRRSDSAVSVPTTQANATRRGSDGEARPLPRVAP--PGTTWRRIKDEDVPHILRSTLPATALPLRVSSPEdSP 2154
Cdd:PTZ00449 686 SKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLPrdEEFPFEPIGDPDAEQPDDIEFFTPPEEERTFFHE-TP 764
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 568967560 2155 AGTPQRKTSDAVVQTEDVaTSKTNSSTSPSLESRDP----PQAPASGPVAPQ 2202
Cdd:PTZ00449 765 ADTPLPDILAEEFKEEDI-HAETGEPDEAMKRPDSPseheDKPPGDHPSLPK 815
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
1911-2245 |
3.49e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 45.93 E-value: 3.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1911 QRPARRVPPPLARPSPEPGSRGRAGAeGTPGARGSRLGLVRMASARSSGSESSDRSGFRRqltfiKESPGLLRRRRSELS 1990
Cdd:PHA03307 80 PANESRSTPTWSLSTLAPASPAREGS-PTPPGPSSPDPPPPTPPPASPPPSPAPDLSEML-----RPVGSPGPPPAASPP 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1991 SADSTASTSQAASPRRGRPALPAvflcsSRCDELRVSPRQPLAAQRSPQAKPGLAPRAPRRTSSESPSRLPVRASPGRPE 2070
Cdd:PHA03307 154 AAGASPAAVASDAASSRQAALPL-----SSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSA 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 2071 TVKRYASlphisvsrRSDSAVSVPTTQANATRrgsdgEARPLPRvAPPGTTWRRIkDEDVPHILRSTL-----PATALPL 2145
Cdd:PHA03307 229 ADDAGAS--------SSDSSSSESSGCGWGPE-----NECPLPR-PAPITLPTRI-WEASGWNGPSSRpgpasSSSSPRE 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 2146 RVSSPEDSPAGTPQRKTSDAVVQTEDVATSKTNSSTSPSLESRDPPQAPASGPVAPQGSDVDGPVLTKPP----ASAPFP 2221
Cdd:PHA03307 294 RSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSsprkRPRPSR 373
|
330 340
....*....|....*....|....
gi 568967560 2222 HEGLSAVIAGFPTSRHGSPSRAAR 2245
Cdd:PHA03307 374 APSSPAASAGRPTRRRARAAVAGR 397
|
|
| PHA03321 |
PHA03321 |
tegument protein VP11/12; Provisional |
2032-2262 |
5.54e-04 |
|
tegument protein VP11/12; Provisional
Pssm-ID: 223041 [Multi-domain] Cd Length: 694 Bit Score: 45.33 E-value: 5.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 2032 LAAQRSPqakPGlaPRAPRRTSSESPsrlPVRASPGRPETVKRYASlphisvSRRSDSAVSVPTTQANATRRGSDGEAR- 2110
Cdd:PHA03321 424 LLSSRQP---PG--APAPRRDNDPPP---PPRARPGSTPACARRAR------AQRARDAGPEYVDPLGALRRLPAGAAPp 489
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 2111 PLPRVAPPGTTWRRIKDEDVPHiLRSTLPATALPLRVSSPedSPAGTPQRKTSDAVVQTEDVATSKTNSSTSPSLESRDP 2190
Cdd:PHA03321 490 PEPAAAPSPATYYTRMGGGPPR-LPPRNRATETLRPDWGP--PAAAPPEQMEDPYLEPDDDRFDRRDGAAAAATSHPREA 566
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 2191 PqAPASGPVAPQGSDVDGPV-------------LTKPPASAPFPHEGLS---------AVIAGFPTSRHGSPSRAARVPP 2248
Cdd:PHA03321 567 P-APDDDPIYEGVSDSEEPVyeeiptprvyqnpLPRPMEGAGEPPDLDAptspwveeeNPIYGWGDSPLFSPPPAARFPP 645
|
250
....*....|....
gi 568967560 2249 FNYVPSPMAAATMA 2262
Cdd:PHA03321 646 PDPALSPEPPALPA 659
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1376-1398 |
6.39e-04 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Pssm-ID: 461781 Cd Length: 24 Bit Score: 38.90 E-value: 6.39e-04
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1978-2198 |
2.00e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 43.77 E-value: 2.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1978 SPGLLRRRRSELSSADSTASTSQAASPRRGRPALPAVFLCSSRCDELRVSP-RQPLAAQRSPQAKPGLAPRAP---RRTS 2053
Cdd:PHA03247 256 APPPVVGEGADRAPETARGATGPPPPPEAAAPNGAAAPPDGVWGAALAGAPlALPAPPDPPPPAPAGDAEEEDdedGAME 335
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 2054 SESP-----SRLPVRASPGRPETVKRYASLPHISVSRRSDSAVSVPTTQANATR-------RGSDGEARPLPRVAPPGTT 2121
Cdd:PHA03247 336 VVSPlprprQHYPLGFPKRRRPTWTPPSSLEDLSAGRHHPKRASLPTRKRRSARhaatpfaRGPGGDDQTRPAAPVPASV 415
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568967560 2122 wrriKDEDVPHILRSTLPATALPLRVSSP--EDSPAGTPQRKTSDAVVQTEDVATSKTNSSTSPSLESRDPPQAPASGP 2198
Cdd:PHA03247 416 ----PTPAPTPVPASAPPPPATPLPSAEPgsDDGPAPPPERQPPAPATEPAPDDPDDATRKALDALRERRPPEPPGADL 490
|
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
655-695 |
3.11e-03 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 37.43 E-value: 3.11e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 568967560 655 SPRDQELLWDLGAVGMLRNLVHSKHKMIAMGSAAALRNLLA 695
Cdd:pfam00514 1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1253-1274 |
3.52e-03 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Pssm-ID: 461781 Cd Length: 24 Bit Score: 36.59 E-value: 3.52e-03
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
7-245 |
3.87e-03 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 42.20 E-value: 3.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 7 SYEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLEQEARVL--VSSGQTEVLEQLKALQTDIS 84
Cdd:COG4372 32 QLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLqaAQAELAQAQEELESLQEEAE 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 85 SLynlkfhapalgpepaartpegspvhgsgpskdsfgelsRATIrllEELDQERCFLlseiekeekeklwyYSQLQGLSK 164
Cdd:COG4372 112 EL--------------------------------------QEEL---EELQKERQDL--------------EQQRKQLEA 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 165 RLDELPHVDTQFSMQMDLIRQQLEFEAQHIRSLmeerfgtsdEMVQRAQIRASRLEQIDKELLEAQDRVQQTEPQALLAV 244
Cdd:COG4372 137 QIAELQSEIAEREEELKELEEQLESLQEELAAL---------EQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEK 207
|
.
gi 568967560 245 K 245
Cdd:COG4372 208 L 208
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1141-1164 |
5.65e-03 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Pssm-ID: 461781 Cd Length: 24 Bit Score: 36.20 E-value: 5.65e-03
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1291-1628 |
6.12e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 42.23 E-value: 6.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1291 PPACPERAVGGGGHRRRDEAASRLDGPAPAGSRARSATDKeleALRECLG-----AAMPARLRKVASALVPGRRSLPVPv 1365
Cdd:PHA03247 2647 PPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRR---AARPTVGsltslADPPPPPPTPEPAPHALVSATPLP- 2722
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1366 ymLVPAPARGDDSGTDSAEGTPVNFSSAASLSDETlQGPSRDKPAGPGDRQKPTGRAAPArQTRSHRPKAAGAGKSTEHT 1445
Cdd:PHA03247 2723 --PGPAAARQASPALPAAPAPPAVPAGPATPGGPA-RPARPPTTAGPPAPAPPAAPAAGP-PRRLTRPAVASLSESRESL 2798
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1446 RGPcRNRAGLELPLSRPQSARSNRDSSCQTRTRGDGALQS--------LCLTTPTEEAVYCFYD-SDEEPPATAPPPRRA 1516
Cdd:PHA03247 2799 PSP-WDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTapppppgpPPPSLPLGGSVAPGGDvRRRPPSRSPAAKPAA 2877
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1517 SAIPRALKREKPAgrketPSRAAQPATLPVRAQPRLIVDETPPCYSLTSSASSLSEPEAPEQPANHAR---GPEQGSKQD 1593
Cdd:PHA03247 2878 PARPPVRRLARPA-----VSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQpplAPTTDPAGA 2952
|
330 340 350
....*....|....*....|....*....|....*
gi 568967560 1594 SSPSPRAEEELLQRCISLAMPRRRTQVPGSRRRKP 1628
Cdd:PHA03247 2953 GEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSRE 2987
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1862-2247 |
7.87e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 41.85 E-value: 7.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1862 PLPRRSPLATPTGGPLpgpggslvPKSPARALLAKQHKTQKSPVRI----------------------PFMQRPA---RR 1916
Cdd:PHA03247 2496 PDPGGGGPPDPDAPPA--------PSRLAPAILPDEPVGEPVHPRMltwirgleelasddagdpppplPPAAPPAapdRS 2567
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1917 VPPPLARPSP-EPGSRGRAGAEGTP--GARGSRLGLVRMASARSSGSESSDRSGFRRQLTFIKESPGLLRRRRSELSSAD 1993
Cdd:PHA03247 2568 VPPPRPAPRPsEPAVTSRARRPDAPpqSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVP 2647
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 1994 STASTSQAASPRRGRPalpavflcssrcdelrvsPRQPLAAQRSPQAKPglAPRAPRRTSSEsPSRLPVRASPGRPETVK 2073
Cdd:PHA03247 2648 PPERPRDDPAPGRVSR------------------PRRARRLGRAAQASS--PPQRPRRRAAR-PTVGSLTSLADPPPPPP 2706
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 2074 RYASLPHISVsrrsdSAVSVPTTQANATRRGSDGEARPLPRVAPPGTTwrrikdEDVPHILRSTLPATALPLRVSSPEDs 2153
Cdd:PHA03247 2707 TPEPAPHALV-----SATPLPPGPAAARQASPALPAAPAPPAVPAGPA------TPGGPARPARPPTTAGPPAPAPPAA- 2774
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967560 2154 PAGTPQRKTSDAVVQTEDVATSKTNSSTSPS---------LESRDPPQAPASGPVAPQGSDVDGPVLTKPPASAPFPHEG 2224
Cdd:PHA03247 2775 PAAGPPRRLTRPAVASLSESRESLPSPWDPAdppaavlapAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGG 2854
|
410 420
....*....|....*....|...
gi 568967560 2225 lsAVIAGFPTSRHGSPSRAARVP 2247
Cdd:PHA03247 2855 --SVAPGGDVRRRPPSRSPAAKP 2875
|
|
| |
