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Conserved domains on  [gi|568968386|ref|XP_006514104|]
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activating signal cointegrator 1 complex subunit 1 isoform X3 [Mus musculus]

Protein Classification

KH domain-containing protein( domain architecture ID 11621292)

K homology (KH) domain-containing protein may bind single-stranded RNA or DNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AKAP7_NLS pfam10469
AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic ...
 88-311 9.57e-80

AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localization signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function.


:

Pssm-ID: 402204 [Multi-domain]  Cd Length: 207  Bit Score: 241.02  E-value: 9.57e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968386   88 FTHFLSFFLNEVEVQERFLMFQEEVLRKcskDRGVDSTIFQNPKKLHLTIGMLVLLSEQEIQQTCEILQRCKEEFINDIS 167
Cdd:pfam10469   1 PTHFLSIPLNSPELRKRLEEFQESVLKQ---LPGLDESLFIPPEKLHITLLVLVLLDDEEVARAKEALRECREEIKDILN 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968386  168 GGrPLEVEMAGIEYMNDDPAMVDVLYAKVHMKDGSNRLQELVDRVLERFQSLGLIVKEW-TSVKLHATVMNTLLRKDPNa 246
Cdd:pfam10469  78 GN-PLSLRFKGLETFNDDPSAVRVLYAKVEEDDHSPKLQELADRIIRRFQEAGLLVKENnSRVKLHMTLMNTRYRKKKY- 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568968386  247 egrynlytadgkyiFKERESFDGRNILKTFENFYFGSLRLNSIHISQRFTVD-SFGNYASCGHVDF 311
Cdd:pfam10469 156 --------------AKSKESFDAREILDEFKDFDFGTQKVSELHLCSMGSSDeSDGFYHVEASVKL 207
KH-I super family cl00098
K homology (KH) RNA-binding domain, type I; KH binds single-stranded RNA or DNA. It is found ...
 60-79 1.06e-04

K homology (KH) RNA-binding domain, type I; KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that belong to different protein folds, but they share a single KH motif. The KH motif is folded into a beta alpha alpha beta unit. In addition to the core, type II KH domains (e.g. ribosomal protein S3) include an N-terminal extension and type I KH domains (e.g. hnRNP K) contain a C-terminal extension. Some KH-I superfamily members contain a divergent KH domain that lacks the RNA-binding GXXG motif. Some others have a mutated GXXG motif which may or may not have nucleic acid binding ability.


The actual alignment was detected with superfamily member cd22419:

Pssm-ID: 469614 [Multi-domain]  Cd Length: 66  Bit Score: 39.87  E-value: 1.06e-04
                         10        20
                 ....*....|....*....|
gi 568968386  60 ITGQHRNGVVSARTRIDVLL 79
Cdd:cd22419   47 ITGKDRSGVDSARTRIEVLV 66
 
Name Accession Description Interval E-value
AKAP7_NLS pfam10469
AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic ...
 88-311 9.57e-80

AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localization signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function.


Pssm-ID: 402204 [Multi-domain]  Cd Length: 207  Bit Score: 241.02  E-value: 9.57e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968386   88 FTHFLSFFLNEVEVQERFLMFQEEVLRKcskDRGVDSTIFQNPKKLHLTIGMLVLLSEQEIQQTCEILQRCKEEFINDIS 167
Cdd:pfam10469   1 PTHFLSIPLNSPELRKRLEEFQESVLKQ---LPGLDESLFIPPEKLHITLLVLVLLDDEEVARAKEALRECREEIKDILN 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968386  168 GGrPLEVEMAGIEYMNDDPAMVDVLYAKVHMKDGSNRLQELVDRVLERFQSLGLIVKEW-TSVKLHATVMNTLLRKDPNa 246
Cdd:pfam10469  78 GN-PLSLRFKGLETFNDDPSAVRVLYAKVEEDDHSPKLQELADRIIRRFQEAGLLVKENnSRVKLHMTLMNTRYRKKKY- 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568968386  247 egrynlytadgkyiFKERESFDGRNILKTFENFYFGSLRLNSIHISQRFTVD-SFGNYASCGHVDF 311
Cdd:pfam10469 156 --------------AKSKESFDAREILDEFKDFDFGTQKVSELHLCSMGSSDeSDGFYHVEASVKL 207
PLN00108 PLN00108
unknown protein; Provisional
 84-311 1.02e-22

unknown protein; Provisional


Pssm-ID: 177724  Cd Length: 257  Bit Score: 94.75  E-value: 1.02e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968386  84 RRQPFTHFLSFFLN-EVEVQERFLMFQEEVLRKCSKD----------RGVDSTIFQNPKKLHLTIGMLVLLSEQEIQQTC 152
Cdd:PLN00108  32 HREVFTHFVSLPLAiYPDLKKNIEAFQNSVLGNNDKDplkfqstlaeMGIEKSIFVSPKTFHLTVVMLKLENNESVVKAQ 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968386 153 EILQRCKEEfINDISGGRPLEVEMAGIEYMNDDPAMVDVLYAKVHMKDGSNRLQELVDRVLERFQSLGLIVKEWTS-VKL 231
Cdd:PLN00108 112 NILKSICSN-VRQALKDRPVFIRLRGLDCMNGSLDKTRVLYAPVEEVGHEGRLLNACHVIIDAFENAGFAGKDAKSrLKL 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968386 232 HATVMNTLLRKDPNaegrynlytadgkyifKERESFDGRNILKTFENFYFGSLRLNSIHISQRFTVDSFGNYASCGHVDF 311
Cdd:PLN00108 191 HATLMNASYRKDKS----------------KKMDTFDAREIHKEFENKDWGTYLIREAHISQRYKYDPNGYFHCCASLPF 254
ThpR COG1514
RNA 2',3'-cyclic phosphodiesterase (2'-5' RNA ligase) [Translation, ribosomal structure and ...
 91-221 1.48e-05

RNA 2',3'-cyclic phosphodiesterase (2'-5' RNA ligase) [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441123 [Multi-domain]  Cd Length: 181  Bit Score: 44.63  E-value: 1.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968386  91 FLSFFLNEvEVQERFLMFQEEvLRKCSKDRGVDstifqnPKKLHLTIGMLVLLSEQEIQQTCEILQRCKEEFindisggR 170
Cdd:COG1514    4 FIALPPPE-ELREALAALRAR-LKAAPGGRWVR------PENLHLTLAFLGEVDEERLEALAEALARAAAGA-------P 68

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568968386 171 PLEVEMAGIEYMNDDPAmvDVLYAKVhmkDGSNRLQELVDRVLERFQSLGL 221
Cdd:COG1514   69 PFELRLDGLGAFPRPRP--RVLWLGV---EPSPELLALHRRLRAALARAGL 114
KH-I_ASCC1 cd22419
type I K homology (KH) RNA-binding domain found in activating signal cointegrator 1 complex ...
 60-79 1.06e-04

type I K homology (KH) RNA-binding domain found in activating signal cointegrator 1 complex subunit 1 (ASCC1) and similar proteins; ASCC1, also called ASC-1 complex subunit p50, or Trip4 complex subunit p50, plays a role in DNA damage repair as component of the ASCC complex. It is part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. ASCC1 may also play a role in the development of neuromuscular junction.


Pssm-ID: 411847 [Multi-domain]  Cd Length: 66  Bit Score: 39.87  E-value: 1.06e-04
                         10        20
                 ....*....|....*....|
gi 568968386  60 ITGQHRNGVVSARTRIDVLL 79
Cdd:cd22419   47 ITGKDRSGVDSARTRIEVLV 66
 
Name Accession Description Interval E-value
AKAP7_NLS pfam10469
AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic ...
 88-311 9.57e-80

AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localization signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function.


Pssm-ID: 402204 [Multi-domain]  Cd Length: 207  Bit Score: 241.02  E-value: 9.57e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968386   88 FTHFLSFFLNEVEVQERFLMFQEEVLRKcskDRGVDSTIFQNPKKLHLTIGMLVLLSEQEIQQTCEILQRCKEEFINDIS 167
Cdd:pfam10469   1 PTHFLSIPLNSPELRKRLEEFQESVLKQ---LPGLDESLFIPPEKLHITLLVLVLLDDEEVARAKEALRECREEIKDILN 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968386  168 GGrPLEVEMAGIEYMNDDPAMVDVLYAKVHMKDGSNRLQELVDRVLERFQSLGLIVKEW-TSVKLHATVMNTLLRKDPNa 246
Cdd:pfam10469  78 GN-PLSLRFKGLETFNDDPSAVRVLYAKVEEDDHSPKLQELADRIIRRFQEAGLLVKENnSRVKLHMTLMNTRYRKKKY- 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568968386  247 egrynlytadgkyiFKERESFDGRNILKTFENFYFGSLRLNSIHISQRFTVD-SFGNYASCGHVDF 311
Cdd:pfam10469 156 --------------AKSKESFDAREILDEFKDFDFGTQKVSELHLCSMGSSDeSDGFYHVEASVKL 207
PLN00108 PLN00108
unknown protein; Provisional
 84-311 1.02e-22

unknown protein; Provisional


Pssm-ID: 177724  Cd Length: 257  Bit Score: 94.75  E-value: 1.02e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968386  84 RRQPFTHFLSFFLN-EVEVQERFLMFQEEVLRKCSKD----------RGVDSTIFQNPKKLHLTIGMLVLLSEQEIQQTC 152
Cdd:PLN00108  32 HREVFTHFVSLPLAiYPDLKKNIEAFQNSVLGNNDKDplkfqstlaeMGIEKSIFVSPKTFHLTVVMLKLENNESVVKAQ 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968386 153 EILQRCKEEfINDISGGRPLEVEMAGIEYMNDDPAMVDVLYAKVHMKDGSNRLQELVDRVLERFQSLGLIVKEWTS-VKL 231
Cdd:PLN00108 112 NILKSICSN-VRQALKDRPVFIRLRGLDCMNGSLDKTRVLYAPVEEVGHEGRLLNACHVIIDAFENAGFAGKDAKSrLKL 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968386 232 HATVMNTLLRKDPNaegrynlytadgkyifKERESFDGRNILKTFENFYFGSLRLNSIHISQRFTVDSFGNYASCGHVDF 311
Cdd:PLN00108 191 HATLMNASYRKDKS----------------KKMDTFDAREIHKEFENKDWGTYLIREAHISQRYKYDPNGYFHCCASLPF 254
ThpR COG1514
RNA 2',3'-cyclic phosphodiesterase (2'-5' RNA ligase) [Translation, ribosomal structure and ...
 91-221 1.48e-05

RNA 2',3'-cyclic phosphodiesterase (2'-5' RNA ligase) [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441123 [Multi-domain]  Cd Length: 181  Bit Score: 44.63  E-value: 1.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968386  91 FLSFFLNEvEVQERFLMFQEEvLRKCSKDRGVDstifqnPKKLHLTIGMLVLLSEQEIQQTCEILQRCKEEFindisggR 170
Cdd:COG1514    4 FIALPPPE-ELREALAALRAR-LKAAPGGRWVR------PENLHLTLAFLGEVDEERLEALAEALARAAAGA-------P 68

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568968386 171 PLEVEMAGIEYMNDDPAmvDVLYAKVhmkDGSNRLQELVDRVLERFQSLGL 221
Cdd:COG1514   69 PFELRLDGLGAFPRPRP--RVLWLGV---EPSPELLALHRRLRAALARAGL 114
KH-I_ASCC1 cd22419
type I K homology (KH) RNA-binding domain found in activating signal cointegrator 1 complex ...
 60-79 1.06e-04

type I K homology (KH) RNA-binding domain found in activating signal cointegrator 1 complex subunit 1 (ASCC1) and similar proteins; ASCC1, also called ASC-1 complex subunit p50, or Trip4 complex subunit p50, plays a role in DNA damage repair as component of the ASCC complex. It is part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. ASCC1 may also play a role in the development of neuromuscular junction.


Pssm-ID: 411847 [Multi-domain]  Cd Length: 66  Bit Score: 39.87  E-value: 1.06e-04
                         10        20
                 ....*....|....*....|
gi 568968386  60 ITGQHRNGVVSARTRIDVLL 79
Cdd:cd22419   47 ITGKDRSGVDSARTRIEVLV 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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