BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778 785 PKLTEIKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTCIEIGYVKYPIFQLVMQ 864
Cdd:cd18351    1 PKLTEIKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSNKPSAENTCIEISYVKYHIFQLVMQ 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568968778 865 YLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCVD 915
Cdd:cd18351   81 YLYCGGTESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTENCVD 131

histone-fold domain found in ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; ABTB2, also called Bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, which has implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). This subfamily also includes BTB/POZ domain-containing protein 11 (BTBD11), also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11. It is a BTB-domain-containing Kelch-like protein with unknown function.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778 193 SAGGDRLGRGKSARCGLTFSVGRVYRWMVDSRVALRIHEHAAIYLTACMESLFRDIYSRVLASGLPrscsgpgpgsssgs 272
Cdd:cd22913    1 MSSGDQLRRSKSARCGLTFSVGRFHRWMVDSRLAKRIHEHAAVYLTACMENLLEEIFLRALASLVP-------------- 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778 273 gpgpgsgpgapaadkeretpgggaasggpcsaassasggssccappataatavppttataavaanhhhhhhtlHEAPKFT 352
Cdd:cd22913   67 -------------------------------------------------------------------------KGELELT 73

                        170       180       190
                 ....*....|....*....|....*....|..
gi 568968778 353 VETLEHTVNNDSEIWGLLQPYQHLICGKNASG 384
Cdd:cd22913   74 VEALEYGINNDAELWGLLQPYEHLICGRNASG 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778 785 PKLTEIKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTCIEIGYVKYPIFQLVMQ 864
Cdd:cd18351    1 PKLTEIKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSNKPSAENTCIEISYVKYHIFQLVMQ 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568968778 865 YLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCVD 915
Cdd:cd18351   81 YLYCGGTESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTENCVD 131

histone-fold domain found in ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; ABTB2, also called Bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, which has implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). This subfamily also includes BTB/POZ domain-containing protein 11 (BTBD11), also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11. It is a BTB-domain-containing Kelch-like protein with unknown function.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778 193 SAGGDRLGRGKSARCGLTFSVGRVYRWMVDSRVALRIHEHAAIYLTACMESLFRDIYSRVLASGLPrscsgpgpgsssgs 272
Cdd:cd22913    1 MSSGDQLRRSKSARCGLTFSVGRFHRWMVDSRLAKRIHEHAAVYLTACMENLLEEIFLRALASLVP-------------- 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778 273 gpgpgsgpgapaadkeretpgggaasggpcsaassasggssccappataatavppttataavaanhhhhhhtlHEAPKFT 352
Cdd:cd22913   67 -------------------------------------------------------------------------KGELELT 73

                        170       180       190
                 ....*....|....*....|....*....|..
gi 568968778 353 VETLEHTVNNDSEIWGLLQPYQHLICGKNASG 384
Cdd:cd22913   74 VEALEYGINNDAELWGLLQPYEHLICGRNASG 105

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778   810 DVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDN-TCIEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEIMELLSAA 888
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDkSEIYLDDVSPEDFRALLNFLYTG---KLDLPEENVEELLELA 77

                           90       100
                   ....*....|....*....|
gi 568968778   889 KFFQLEALQRHCEIICAKSI 908
Cdd:smart00225  78 DYLQIPGLVELCEEFLLKLL 97

Ankyrin repeats (3 copies);

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778  585 GRTDLVKQAvsLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDaGADLNVEvvstphkypsvhpeTRHWTALTFAVL 664
Cdd:pfam12796   8 GNLELVKLL--LENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLK--------------DNGRTALHYAAR 70

                          90
                  ....*....|....*..
gi 568968778  665 HGHIPVVQLLLDAGAKV 681
Cdd:pfam12796  71 SGHLEIVKLLLEKGADI 87

Histone H2A [Chromatin structure and dynamics];

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568968778 192 SSAGGDRLGRGKSARCGLTFSVGRVYRWMVDSRVALRIHEHAAIYLTACMESLFRDI 248
Cdd:COG5262    8 GKAADARVSQSRSAKAGLIFPVGRVKRLLKKGNYRMRIGAGAPVYLAAVLEYLAAEI 64

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.

                           10        20        30
                   ....*....|....*....|....*....|
gi 568968778   608 QGMTPLMYACVRGDEAMVQMLLDAGADLNV 637
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30

ankyrin-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778 586 RTDLVKQAVSLL---GPDgINTMSEQGMTPL-MYACVRGDEAMVQMLLDAGADLNVEVVS--TP-HKY---PSVHPetrh 655
Cdd:PHA03095  58 SSEKVKDIVRLLleaGAD-VNAPERCGFTPLhLYLYNATTLDVIKLLIKAGADVNAKDKVgrTPlHVYlsgFNINP---- 132

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 568968778 656 wtaltfavlhghiPVVQLLLDAGAKVEGSvehgeENYSETPL 697
Cdd:PHA03095 133 -------------KVIRLLLRKGADVNAL-----DLYGMTPL 156

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778 785 PKLTEIKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTCIEIGYVKYPIFQLVMQ 864
Cdd:cd18351    1 PKLTEIKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSNKPSAENTCIEISYVKYHIFQLVMQ 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568968778 865 YLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCVD 915
Cdd:cd18351   81 YLYCGGTESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTENCVD 131

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778 785 PKLTEIKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNT---CIEIGYVKYPIFQL 861
Cdd:cd18350    1 PSIPEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKSLLTNKSEQESQgskTIEISDIKYHIFQM 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568968778 862 VMQYLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCV 914
Cdd:cd18350   81 LMQYLYYGGTESMEIPIADVLELLSAASLFQLDALQRHCEILCSQTINLENAV 133

histone-fold domain found in ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; ABTB2, also called Bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, which has implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). This subfamily also includes BTB/POZ domain-containing protein 11 (BTBD11), also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11. It is a BTB-domain-containing Kelch-like protein with unknown function.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778 193 SAGGDRLGRGKSARCGLTFSVGRVYRWMVDSRVALRIHEHAAIYLTACMESLFRDIYSRVLASGLPrscsgpgpgsssgs 272
Cdd:cd22913    1 MSSGDQLRRSKSARCGLTFSVGRFHRWMVDSRLAKRIHEHAAVYLTACMENLLEEIFLRALASLVP-------------- 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778 273 gpgpgsgpgapaadkeretpgggaasggpcsaassasggssccappataatavppttataavaanhhhhhhtlHEAPKFT 352
Cdd:cd22913   67 -------------------------------------------------------------------------KGELELT 73

                        170       180       190
                 ....*....|....*....|....*....|..
gi 568968778 353 VETLEHTVNNDSEIWGLLQPYQHLICGKNASG 384
Cdd:cd22913   74 VEALEYGINNDAELWGLLQPYEHLICGRNASG 105

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called Bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications in Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homologue (PTEN).

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568968778 908 INTDNCVDIYSHAKFLGVTELSAYCEGYFLKNMMVLIENEAFKQLLYDKNGEGAGQDVLQDLQRTLAIRIQSIHLSS 984
Cdd:cd18526    1 INLENSVSIYKYAKIHNAPELASFCEGFFLKNMKALLEQDSFRQLIYGRNSKVQGLDPLQDLQVTLAKRMHSIYITS 77

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778 798 LDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSK-PTNDNTCIEIGYVKYPIFQLVMQYLYYGgpeSLLI 876
Cdd:cd18352    3 LGEQYVNNATLSDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGyREKEARDIEIPNIRWEVFELMMRFIYTG---SVDI 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568968778 877 KNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDN 912
Cdd:cd18352   80 TNDIAKDLLRAADQYLLEGLKRLCEYTIAQDLTLEN 115

Ankyrin repeat [Signal transduction mechanisms];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778 585 GRTDLVKQavsLL--GPDgINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNvevvstphkypsvHPETRHWTALTFA 662
Cdd:COG0666  131 GNLEIVKL---LLeaGAD-VNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVN-------------ARDNDGETPLHLA 193

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 568968778 663 VLHGHIPVVQLLLDAGAKVegsveHGEENYSETPLQLAAAVG 704
Cdd:COG0666  194 AENGHLEIVKLLLEAGADV-----NAKDNDGKTALDLAAENG 230

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778 808 MSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSK-PTNDNTCIEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEIMELLS 886
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGmKESSSSEIELDDVSPEAFEALLDYIYTG---ELELSEENVEELLA 77

                 ....*
gi 568968778 887 AAKFF 891
Cdd:cd18186   78 AADKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778 803 LNNKEMSDVTFLV--EGRPFYAHKVLLFTASPRFKALLSSKPTNDNTCIEIGYVKYP--IFQLVMQYLYYGgpeSLLIKN 878
Cdd:cd18294    9 INNPEFSDVKFLVgpERQEIFAHKCILAARCEVFRAMFLTGPQKESTQSPLVLSDIEpeVFRAVLEFIYTN---CVTLSN 85

                         90       100
                 ....*....|....*....|...
gi 568968778 879 NEIMELLSAAKFFQLEALQRHCE 901
Cdd:cd18294   86 HTVIEVLAAAVEYGLDELRKLCE 108

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778 801 HFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPT-NDNTCIEIGYVKYPIFQLVMQYLYYGgpESLLIKNN 879
Cdd:cd18300    2 LFLNKGLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFReSSAKEVELPGVSKETFLALLEYLYTD--QAPILEDG 79

                         90       100
                 ....*....|....*....|..
gi 568968778 880 EIMELLSAAKFFQLEALQRHCE 901
Cdd:cd18300   80 DCVGLIVLANRLCLPRLVALCE 101

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778 810 DVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTCIEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEIMELLSAAK 889
Cdd:cd18315    3 DVTLACEGGSLKAHKLVLAAASPYFAALLKETPPDEHPVIILPDVPYSELKALLDFIYTG---EVNVSQEQLESLLKLAE 79

                 ...
gi 568968778 890 FFQ 892
Cdd:cd18315   80 LLQ 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778 802 FLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKAL-LSSKPTNDNTCIEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNE 880
Cdd:cd18270   20 FYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMfMSGLSESKQTHVHLRNVDAATLQIIITYAYTG---NLAINDST 96

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568968778 881 IMELLSAAKFFQLEALQRHCEIICAKSINTDNCV 914
Cdd:cd18270   97 VEQLYETACFLQVEDVLQRCREYLIKKINAENCV 130

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778 805 NKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTC-IEIGYVKYPIFQLVMQYLYYGgpeSLLIKNNEIME 883
Cdd:cd18237   18 QKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSeVELKDAEPDIIELLVEFAYTA---RISVNSNNVQS 94

                         90       100       110
                 ....*....|....*....|....*....|.
gi 568968778 884 LLSAAKFFQLEALQRHCEIICAKSINTDNCV 914
Cdd:cd18237   95 LLDAANQYQIEPVKKMCVDFLKEQLDASNCL 125

kelch-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778 807 EMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTCIeigYVKYPIFQLVMQYLYYGgpeSLLIKNNEIMELLS 886
Cdd:PHA03098  10 CDESIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENEINL---NIDYDSFNEVIKYIYTG---KINITSNNVKDILS 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568968778 887 AAKFFQLEALQRHCEIICAKSINTDNCVDIYSHAKFLGVTELSAYCEGYFLKNMMVLIENEAFKQLLYD 955
Cdd:PHA03098  84 IANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKN 152

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778 803 LNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTC-IEIGYVKYPIFQLVMQYLYYGGPESLLIKNNEI 881
Cdd:cd18287   17 FLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSeIELKDTNAEAFKALLKYIYTGRLTLTDLKEDVL 96

                         90
                 ....*....|....*.
gi 568968778 882 MELLSAAKFFQLEALQ 897
Cdd:cd18287   97 LDVLGLAHQYGFEELE 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778 802 FLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTCIEIGYVKYP----IFQLVMQYLYYGgpeSLLIK 877
Cdd:cd18292   11 LYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWWSESKQSEIELVEDPecaaVFEKFLRYLYTG---QISVN 87

                         90       100
                 ....*....|....*....|....
gi 568968778 878 NNEIMELLSAAKFFQLEALQRHCE 901
Cdd:cd18292   88 LETALPLLMLADKYNVTDLKQLCV 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778 802 FLNN---KEMS--DVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNtcIEIGYVKYPIFQLVMQYLYyggPESLLI 876
Cdd:cd18226   11 YLNDdrqKQSSfcDLVITVEGKEFSAHKVVVAVGSSYFHACLSKNPNTDA--VTLDHVSYSVFQHLLEFLY---TSEFFV 85

                         90       100
                 ....*....|....*....|..
gi 568968778 877 KNNEIMELLSAAKFFQ-LEALQ 897
Cdd:cd18226   86 YENEIPLVLEAAKFLDiIDAVK 107

Ankyrin repeats (3 copies);

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778  613 LMYACVRGDEAMVQMLLDAGADLNVEvvstphkypsvhpETRHWTALTFAVLHGHIPVVQLLLDAGAKvegsvehGEENY 692
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQ-------------DKNGRTALHLAAKNGHLEIVKLLLEHADV-------NLKDN 60

                          90
                  ....*....|..
gi 568968778  693 SETPLQLAAAVG 704
Cdd:pfam12796  61 GRTALHYAARSG 72

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778 811 VTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDN-TCIEIGYVKYPIFQLVMQYLYYGGPEsllIKNNEIMELLSAAK 889
Cdd:cd01165    1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGqAEINLRDISPEDFRALLEFLYGGKRD---LDASNLLELLEAAN 77

                 ..
gi 568968778 890 FF 891
Cdd:cd01165   78 FL 79

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778 809 SDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNtCIEIGY--VKYPIFQLVMQYLYYGgpeSLLIKNNEIMELLS 886
Cdd:cd18295   20 SDVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDKR-EINLKHplVNPDAFRALLQYLYTG---RLEIHVDDVEDCKR 95

                         90       100
                 ....*....|....*....|
gi 568968778 887 AAKFFQLEALQRHCEIICAK 906
Cdd:cd18295   96 LAKQCRLEELIEELEAKCKK 115

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778 810 DVTFLVEGRPFYAHKVLLFTASPRFKALL----SSKPTNDNTC--IEIGYVKYPIFQLVMQYLYYGGPEsllIKNNEIME 883
Cdd:cd18296   19 DVCFQVEGHRFPCHKAFFCGRSDYFKALLrdhfAESEENNGSIpvVTLHDVSPEVFAIVLYYIYTDDTD---LPPENAYD 95

                         90       100
                 ....*....|....*....|....*
gi 568968778 884 LLSAAKFFQLEALQRHCEIICAKSI 908
Cdd:cd18296   96 VLYVADMYLLPGLKRLCGTVLAQSL 120

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778 802 FLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTCIEIGyvKYP----IFQLVMQYLYygGPESLLIK 877
Cdd:cd18312    3 FRDTGEPSDITVRVGNTTFHLHKFPLCSKSGYFKRLASSSSESDPSEIELN--DFPggaeAFELVAKFCY--GMPINLTA 78

                         90
                 ....*....|....*.
gi 568968778 878 NNeIMELLSAAKFFQL 893
Cdd:cd18312   79 TN-VVGLRCAAEYLEM 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968778 801 HFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSK-PTNDNTCIEIGYVKYPIFQLVMQYLYYGGPESLliknn 879
Cdd:cd18343   14 NLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEmEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNL----- 88

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 568968778 880 EIM--ELLSAAKFFQLEALQRHCEIICAKSINTDN 912
Cdd:cd18343   89 DKMadNLLAAADKYALERLKVMCEEALCNNLSVEN 123