ATP-dependent RNA helicase TDRD9 isoform X3 [Mus musculus]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||||||
| DEAD-like_helicase_N super family | cl28899 | N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase ... |
61-244 | 4.45e-97 | |||||||||
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase superfamily is a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. The N-terminal domain contains the ATP-binding region. The actual alignment was detected with superfamily member cd17988: Pssm-ID: 475120 [Multi-domain] Cd Length: 180 Bit Score: 307.89 E-value: 4.45e-97
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| HrpA super family | cl34328 | HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
59-633 | 6.64e-93 | |||||||||
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; The actual alignment was detected with superfamily member COG1643: Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 318.95 E-value: 6.64e-93
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| Tudor_TDRD9 | cd20431 | Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is ... |
833-933 | 6.68e-55 | |||||||||
Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. : Pssm-ID: 410502 Cd Length: 101 Bit Score: 185.67 E-value: 6.68e-55
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| Name | Accession | Description | Interval | E-value | |||||||||
| DEXHc_TDRD9 | cd17988 | DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
61-244 | 4.45e-97 | |||||||||
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 307.89 E-value: 4.45e-97
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| HrpA | COG1643 | HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
59-633 | 6.64e-93 | |||||||||
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 318.95 E-value: 6.64e-93
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| PRK11131 | PRK11131 | ATP-dependent RNA helicase HrpA; Provisional |
55-664 | 5.13e-72 | |||||||||
ATP-dependent RNA helicase HrpA; Provisional Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 264.23 E-value: 5.13e-72
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| SF2_C_RHA | cd18791 | C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
249-436 | 2.50e-61 | |||||||||
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC. Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 207.00 E-value: 2.50e-61
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| DEAH_box_HrpB | TIGR01970 | ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
61-617 | 6.75e-56 | |||||||||
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity] Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 210.01 E-value: 6.75e-56
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| Tudor_TDRD9 | cd20431 | Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is ... |
833-933 | 6.68e-55 | |||||||||
Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410502 Cd Length: 101 Bit Score: 185.67 E-value: 6.68e-55
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| DEXDc | smart00487 | DEAD-like helicases superfamily; |
73-220 | 5.66e-18 | |||||||||
DEAD-like helicases superfamily; Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 83.70 E-value: 5.66e-18
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| HA2 | smart00847 | Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
516-593 | 1.74e-16 | |||||||||
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding. Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 75.38 E-value: 1.74e-16
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| TUDOR | pfam00567 | Tudor domain; |
832-941 | 3.68e-16 | |||||||||
Tudor domain; Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 75.85 E-value: 3.68e-16
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| HA2 | pfam04408 | Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
494-574 | 7.18e-16 | |||||||||
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding. Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 74.58 E-value: 7.18e-16
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| DEAD | pfam00270 | DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
68-220 | 1.14e-07 | |||||||||
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression. Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 53.02 E-value: 1.14e-07
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| TUDOR | smart00333 | Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ... |
878-929 | 2.63e-07 | |||||||||
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished). Pssm-ID: 197660 Cd Length: 57 Bit Score: 48.42 E-value: 2.63e-07
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| Name | Accession | Description | Interval | E-value | |||||||||
| DEXHc_TDRD9 | cd17988 | DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
61-244 | 4.45e-97 | |||||||||
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 307.89 E-value: 4.45e-97
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| HrpA | COG1643 | HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
59-633 | 6.64e-93 | |||||||||
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 318.95 E-value: 6.64e-93
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| PRK11131 | PRK11131 | ATP-dependent RNA helicase HrpA; Provisional |
55-664 | 5.13e-72 | |||||||||
ATP-dependent RNA helicase HrpA; Provisional Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 264.23 E-value: 5.13e-72
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| DEXHc_RHA-like | cd17917 | DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
77-228 | 5.97e-62 | |||||||||
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 208.47 E-value: 5.97e-62
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| SF2_C_RHA | cd18791 | C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
249-436 | 2.50e-61 | |||||||||
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC. Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 207.00 E-value: 2.50e-61
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| DEAH_box_HrpB | TIGR01970 | ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
61-617 | 6.75e-56 | |||||||||
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity] Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 210.01 E-value: 6.75e-56
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| Tudor_TDRD9 | cd20431 | Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is ... |
833-933 | 6.68e-55 | |||||||||
Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410502 Cd Length: 101 Bit Score: 185.67 E-value: 6.68e-55
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| DEXHc_DHX57 | cd17985 | DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
61-228 | 2.22e-43 | |||||||||
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 155.77 E-value: 2.22e-43
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| PRK11664 | PRK11664 | ATP-dependent RNA helicase HrpB; Provisional |
61-529 | 3.41e-41 | |||||||||
ATP-dependent RNA helicase HrpB; Provisional Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 164.33 E-value: 3.41e-41
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| DEXHc_DHX36 | cd17981 | DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
61-228 | 2.50e-40 | |||||||||
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 147.30 E-value: 2.50e-40
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| DEXHc_DHX33 | cd17978 | DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
61-232 | 4.08e-40 | |||||||||
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 146.73 E-value: 4.08e-40
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| DEXHc_DHX30 | cd17976 | DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
61-228 | 1.73e-39 | |||||||||
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 144.94 E-value: 1.73e-39
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| DEXHc_DHX9 | cd17972 | DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
61-228 | 2.56e-38 | |||||||||
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 143.44 E-value: 2.56e-38
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| DEXHc_DHX29 | cd17975 | DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
61-229 | 1.40e-37 | |||||||||
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 139.66 E-value: 1.40e-37
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| DEXHc_YTHDC2 | cd17987 | DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
61-228 | 1.68e-36 | |||||||||
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 136.11 E-value: 1.68e-36
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| DEXHc_DHX34 | cd17979 | DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
61-229 | 2.24e-35 | |||||||||
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 132.57 E-value: 2.24e-35
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| DEXHc_DHX38 | cd17983 | DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
61-232 | 3.36e-34 | |||||||||
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 129.50 E-value: 3.36e-34
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| DEXHc_DHX40 | cd17984 | DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
61-228 | 2.32e-32 | |||||||||
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 124.20 E-value: 2.32e-32
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| DEXHc_DHX15 | cd17973 | DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
60-228 | 6.62e-32 | |||||||||
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 123.29 E-value: 6.62e-32
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| DEXHc_DHX16 | cd17974 | DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
61-228 | 1.57e-30 | |||||||||
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 119.14 E-value: 1.57e-30
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| DEXHc_HrpA | cd17989 | DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
61-229 | 1.74e-30 | |||||||||
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 118.71 E-value: 1.74e-30
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| DEXHc_DHX37 | cd17982 | DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
61-231 | 2.66e-28 | |||||||||
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 113.22 E-value: 2.66e-28
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| DEXHc_DHX8 | cd17971 | DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
61-228 | 2.16e-27 | |||||||||
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 110.26 E-value: 2.16e-27
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| DEXHc_DHX35 | cd17980 | DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
61-237 | 1.16e-26 | |||||||||
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 108.33 E-value: 1.16e-26
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| DEXHc_HrpB | cd17990 | DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
61-229 | 4.78e-25 | |||||||||
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 103.18 E-value: 4.78e-25
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| DEXDc | smart00487 | DEAD-like helicases superfamily; |
73-220 | 5.66e-18 | |||||||||
DEAD-like helicases superfamily; Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 83.70 E-value: 5.66e-18
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| HA2 | smart00847 | Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
516-593 | 1.74e-16 | |||||||||
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding. Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 75.38 E-value: 1.74e-16
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| TUDOR | pfam00567 | Tudor domain; |
832-941 | 3.68e-16 | |||||||||
Tudor domain; Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 75.85 E-value: 3.68e-16
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| HA2 | pfam04408 | Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
494-574 | 7.18e-16 | |||||||||
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding. Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 74.58 E-value: 7.18e-16
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| DEXQc_DQX1 | cd17986 | DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
61-193 | 2.32e-14 | |||||||||
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 72.62 E-value: 2.32e-14
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| DEXHc_DHX32 | cd17977 | DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
61-193 | 1.18e-13 | |||||||||
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 70.62 E-value: 1.18e-13
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| Tudor_TDRD6_rpt3 | cd20422 | third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ... |
832-958 | 4.01e-13 | |||||||||
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410493 Cd Length: 135 Bit Score: 67.92 E-value: 4.01e-13
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| HELICc | smart00490 | helicase superfamily c-terminal domain; |
331-427 | 7.54e-12 | |||||||||
helicase superfamily c-terminal domain; Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 62.23 E-value: 7.54e-12
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| Tudor_TDRD6_rpt5 | cd20424 | fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ... |
848-941 | 6.92e-11 | |||||||||
fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410495 Cd Length: 126 Bit Score: 60.98 E-value: 6.92e-11
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| Helicase_C | pfam00271 | Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
311-428 | 1.52e-10 | |||||||||
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase. Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 59.53 E-value: 1.52e-10
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| Tudor_AKAP1 | cd20407 | Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; ... |
869-938 | 4.40e-10 | |||||||||
Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410478 Cd Length: 76 Bit Score: 57.22 E-value: 4.40e-10
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| SF2-N | cd00046 | N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
77-218 | 6.02e-10 | |||||||||
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region. Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 58.95 E-value: 6.02e-10
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| Tudor_TDRD1_rpt2 | cd20409 | second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ... |
851-930 | 3.11e-09 | |||||||||
second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410480 Cd Length: 82 Bit Score: 54.77 E-value: 3.11e-09
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| PHA02653 | PHA02653 | RNA helicase NPH-II; Provisional |
76-434 | 5.23e-09 | |||||||||
RNA helicase NPH-II; Provisional Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 60.76 E-value: 5.23e-09
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| Tudor_dTUD-like | cd20379 | Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ... |
875-925 | 7.59e-09 | |||||||||
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410450 Cd Length: 50 Bit Score: 52.90 E-value: 7.59e-09
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| Tudor_TDRD1_rpt4 | cd20411 | fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ... |
832-935 | 1.41e-08 | |||||||||
fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410482 Cd Length: 116 Bit Score: 53.99 E-value: 1.41e-08
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| Tudor_TDRD15_rpt4 | cd20439 | fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ... |
819-942 | 3.48e-08 | |||||||||
fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410510 Cd Length: 125 Bit Score: 53.26 E-value: 3.48e-08
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| Tudor_TDRD4_rpt5 | cd20418 | fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ... |
875-951 | 5.37e-08 | |||||||||
fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410489 Cd Length: 105 Bit Score: 52.03 E-value: 5.37e-08
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| Tudor_TDRD2 | cd20412 | Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, ... |
876-938 | 6.26e-08 | |||||||||
Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410483 Cd Length: 95 Bit Score: 51.53 E-value: 6.26e-08
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| Tudor_TDRD12_rpt2 | cd20435 | second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; ... |
876-946 | 6.44e-08 | |||||||||
second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410506 Cd Length: 134 Bit Score: 52.64 E-value: 6.44e-08
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| DEAD | pfam00270 | DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
68-220 | 1.14e-07 | |||||||||
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression. Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 53.02 E-value: 1.14e-07
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| TUDOR | smart00333 | Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ... |
878-929 | 2.63e-07 | |||||||||
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished). Pssm-ID: 197660 Cd Length: 57 Bit Score: 48.42 E-value: 2.63e-07
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| Tudor_TDRD6_rpt4 | cd20423 | fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ... |
872-938 | 5.30e-07 | |||||||||
fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410494 Cd Length: 80 Bit Score: 48.63 E-value: 5.30e-07
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| Tudor_TDRD15_rpt5 | cd20440 | fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ... |
832-939 | 6.11e-07 | |||||||||
fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410511 Cd Length: 127 Bit Score: 49.76 E-value: 6.11e-07
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| Tudor_TDRD4_rpt2 | cd20415 | second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ... |
873-946 | 1.86e-06 | |||||||||
second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410486 Cd Length: 96 Bit Score: 47.43 E-value: 1.86e-06
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| Tudor_TDRD1_rpt3 | cd20410 | third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ... |
873-930 | 1.90e-06 | |||||||||
third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 46.18 E-value: 1.90e-06
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| Tudor_TDRD7_rpt1 | cd20427 | first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ... |
889-946 | 2.12e-06 | |||||||||
first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410498 Cd Length: 98 Bit Score: 47.42 E-value: 2.12e-06
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| DEXHc_viral_Ns3 | cd17931 | DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ... |
79-218 | 4.96e-06 | |||||||||
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Pssm-ID: 350689 [Multi-domain] Cd Length: 151 Bit Score: 47.93 E-value: 4.96e-06
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| Tudor_TDRD15_rpt3 | cd20438 | third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ... |
832-937 | 1.89e-05 | |||||||||
third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410509 Cd Length: 141 Bit Score: 45.93 E-value: 1.89e-05
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| Tudor_TDRD11 | cd20433 | Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, ... |
851-929 | 8.28e-05 | |||||||||
Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 42.29 E-value: 8.28e-05
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| Tudor_TDRD6_rpt7 | cd20426 | seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ... |
840-969 | 2.46e-04 | |||||||||
seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410497 Cd Length: 140 Bit Score: 42.49 E-value: 2.46e-04
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| Tudor_TDRD15_rpt6 | cd20441 | sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ... |
876-933 | 4.60e-04 | |||||||||
sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410512 Cd Length: 108 Bit Score: 40.88 E-value: 4.60e-04
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| Tudor_TDRD3 | cd20413 | Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is ... |
879-925 | 1.97e-03 | |||||||||
Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410484 Cd Length: 53 Bit Score: 37.71 E-value: 1.97e-03
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| Tudor_TDRD1_rpt1 | cd20408 | first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ... |
832-946 | 2.92e-03 | |||||||||
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410479 Cd Length: 130 Bit Score: 39.28 E-value: 2.92e-03
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