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Conserved domains on  [gi|568981872|ref|XP_006516759|]
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probable small intestine urate exporter isoform X4 [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 37-370 2.30e-112

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17318:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 389  Bit Score: 334.59  E-value: 2.30e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  37 AFILHLCNFSIYTQQMNLSFAITAMVNTTVASSQLNASTERPPtnsqdvwnetlQESKAPVYDWTPEIQGILLSSLSYGS 116
Cdd:cd17318    1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTSTDKDT-----------LPVEAPEFDWSEKTQGIILSSFFYGY 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 117 FIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADAGVALLIVLRVIQGMAQVMVLTGQYSLWAKWAPPQERSQLI 196
Cdd:cd17318   70 ILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLT 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 197 TIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLVyddpqnhpfistgerryitcslaqedcslgw 276
Cdd:cd17318  150 SIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV------------------------------- 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 277 slpikamvksLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGLLADFLLSRKIL 356
Cdd:cd17318  199 ----------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGIL 268

                        330
                 ....*....|....
gi 568981872 357 RLVTIRKLFTAGSL 370
Cdd:cd17318  269 STTTVRKLFTSIGF 282
 
Name Accession Description Interval E-value
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 37-370 2.30e-112

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 334.59  E-value: 2.30e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  37 AFILHLCNFSIYTQQMNLSFAITAMVNTTVASSQLNASTERPPtnsqdvwnetlQESKAPVYDWTPEIQGILLSSLSYGS 116
Cdd:cd17318    1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTSTDKDT-----------LPVEAPEFDWSEKTQGIILSSFFYGY 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 117 FIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADAGVALLIVLRVIQGMAQVMVLTGQYSLWAKWAPPQERSQLI 196
Cdd:cd17318   70 ILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLT 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 197 TIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLVyddpqnhpfistgerryitcslaqedcslgw 276
Cdd:cd17318  150 SIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV------------------------------- 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 277 slpikamvksLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGLLADFLLSRKIL 356
Cdd:cd17318  199 ----------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGIL 268

                        330
                 ....*....|....
gi 568981872 357 RLVTIRKLFTAGSL 370
Cdd:cd17318  269 STTTVRKLFTSIGF 282
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 27-367 1.94e-102

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 311.68  E-value: 1.94e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872   27 KGFCSLRHGLAFILHLCNFSIYTQQMNLSFAITAMVNTTVASSQLNASTERPPTNSQDvwnetlqeskaPVYDWTPEIQG 106
Cdd:TIGR00894  11 PYFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNKENSTDLACLSAENELDNIKN-----------PNFKWSGALQG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  107 ILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADAGVALLIVLRVIQGMAQVMVLTGQYSLWAKW 186
Cdd:TIGR00894  80 LILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKW 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  187 APPQERSQLITIAASGSMLGTFLVLIAGGLICQA-LGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFISTGERRYITC 265
Cdd:TIGR00894 160 APPKERSRLLGMSTSGFQLGTFIFLPISGWLCESwGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINS 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  266 SLAQEDCSLGWSLPIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGL 345
Cdd:TIGR00894 240 SLQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGY 319

                         330       340
                  ....*....|....*....|..
gi 568981872  346 LADFLLSRKILRLVTIRKLFTA 367
Cdd:TIGR00894 320 LADFLKSSKTLSLTAARKIFNG 341
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
98-356 7.59e-26

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 107.26  E-value: 7.59e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  98 YDWTPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAAdaGVALLIVLRVIQGMAQVMVLT 177
Cdd:COG2271   40 LGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFP 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 178 GQYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGcaccLLWFPlvyddpqnhpfist 257
Cdd:COG2271  118 AALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPG----LLLAL-------------- 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 258 gerryitcslaqedcslgwslpikamvksLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGC 337
Cdd:COG2271  180 -----------------------------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGI 230

                        250
                 ....*....|....*....
gi 568981872 338 VCIILGGLLADFLLSRKIL 356
Cdd:COG2271  231 VGSLLGGWLSDRLGRRRKL 249
MFS_1 pfam07690
Major Facilitator Superfamily;
98-373 2.75e-25

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 105.58  E-value: 2.75e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872   98 YDWTPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAAdaGVALLIVLRVIQGMAQVMVLT 177
Cdd:pfam07690  27 LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS--SLWLLLVLRVLQGLGAGALFP 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  178 GQYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFpLVYDDPQNHPFIST 257
Cdd:pfam07690 105 AALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLL-LPRPPPESKRPKPA 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  258 GERRYITcslaqedcslgwSLPIKAMVKSLPLWAIVVSyFCEYWLLSTVMAYTPTYIsSVLQANLRDSGILSALPFMFGC 337
Cdd:pfam07690 184 EEARLSL------------IVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGA 249

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 568981872  338 VCIILGGLLADFLLSRKILRLVTIRKLFTAGSLPHL 373
Cdd:pfam07690 250 IGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLL 285
 
Name Accession Description Interval E-value
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 37-370 2.30e-112

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 334.59  E-value: 2.30e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  37 AFILHLCNFSIYTQQMNLSFAITAMVNTTVASSQLNASTERPPtnsqdvwnetlQESKAPVYDWTPEIQGILLSSLSYGS 116
Cdd:cd17318    1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTSTDKDT-----------LPVEAPEFDWSEKTQGIILSSFFYGY 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 117 FIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADAGVALLIVLRVIQGMAQVMVLTGQYSLWAKWAPPQERSQLI 196
Cdd:cd17318   70 ILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLT 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 197 TIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLVyddpqnhpfistgerryitcslaqedcslgw 276
Cdd:cd17318  150 SIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV------------------------------- 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 277 slpikamvksLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGLLADFLLSRKIL 356
Cdd:cd17318  199 ----------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGIL 268

                        330
                 ....*....|....
gi 568981872 357 RLVTIRKLFTAGSL 370
Cdd:cd17318  269 STTTVRKLFTSIGF 282
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 27-367 1.94e-102

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 311.68  E-value: 1.94e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872   27 KGFCSLRHGLAFILHLCNFSIYTQQMNLSFAITAMVNTTVASSQLNASTERPPTNSQDvwnetlqeskaPVYDWTPEIQG 106
Cdd:TIGR00894  11 PYFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNKENSTDLACLSAENELDNIKN-----------PNFKWSGALQG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  107 ILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADAGVALLIVLRVIQGMAQVMVLTGQYSLWAKW 186
Cdd:TIGR00894  80 LILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKW 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  187 APPQERSQLITIAASGSMLGTFLVLIAGGLICQA-LGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFISTGERRYITC 265
Cdd:TIGR00894 160 APPKERSRLLGMSTSGFQLGTFIFLPISGWLCESwGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINS 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  266 SLAQEDCSLGWSLPIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGL 345
Cdd:TIGR00894 240 SLQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGY 319

                         330       340
                  ....*....|....*....|..
gi 568981872  346 LADFLLSRKILRLVTIRKLFTA 367
Cdd:TIGR00894 320 LADFLKSSKTLSLTAARKIFNG 341
MFS_SLC17A5 cd17381
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ...
 36-366 2.29e-73

Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340939 [Multi-domain]  Cd Length: 397  Bit Score: 234.67  E-value: 2.29e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  36 LAFILHLCNFSIYTQQMNLSFAITAMVNTTVASSQLNASTERP-PTNSQDVwnetLQESKAPVYDWTPEIQGILLSSLSY 114
Cdd:cd17381    1 LALLAFFGFFVVYALRVNLSVALVDMVNSNSTLPSNNSSNACPeHSSSPSV----EHNETGKKYDWDAETQGWILGSFFY 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 115 GSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADAGVALLIVLRVIQGMAQVMVLTGQYSLWAKWAPPQERSQ 194
Cdd:cd17381   77 GYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 195 LITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLVyddpqnhpfistgerryitcslaqedcsl 274
Cdd:cd17381  157 LLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLV----------------------------- 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 275 gwslpikamvksLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGLLADFLLSRK 354
Cdd:cd17381  208 ------------MPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQ 275

                        330
                 ....*....|..
gi 568981872 355 ILRLVTIRKLFT 366
Cdd:cd17381  276 NFSTVCVRKIFT 287
MFS_SLC17A6_7_8_VGluT cd17382
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ...
 53-368 2.99e-48

Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340940 [Multi-domain]  Cd Length: 380  Bit Score: 168.67  E-value: 2.99e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  53 NLSFAITAMV-NTTVASSQLNASTErpptnsqdvwnetlqeskaPVYDWTPEIQGILLSSLSYGSFIAPIPTGYVAGVFG 131
Cdd:cd17382   17 NLGVAIVRMVnNFTDAYGGKVIVHK-------------------AEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 132 AKYVVGLGLLISSVLTLFIPLAADAGVALLIVLRVIQGMAQVMVLTGQYSLWAKWAPPQERSQLITIAASGSMLGTFLVL 211
Cdd:cd17382   78 ANRVFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGM 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 212 IAGGLICQALGWPYIFYIFGGIGCacclLWFplvyddpqnhpfistgerryitcslaqedcsLGWslpikaMVKSLPLWA 291
Cdd:cd17382  158 PLSGILVQYVGWSSPFYVYGVFGI----IWY-------------------------------MFW------MLVSMPVYA 196

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568981872 292 IVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGLLADFLLSRKILRLVTIRKLFTAG 368
Cdd:cd17382  197 IIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTAVRKIFNCG 273
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 98-366 2.09e-42

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 152.32  E-value: 2.09e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  98 YDWTPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADAGVALLIVLRVIQGMAQVMVLT 177
Cdd:cd17380   29 FGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFP 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 178 GQYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLVyddpqnhpfist 257
Cdd:cd17380  109 SMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYL------------ 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 258 gerryitcslaqedcslgwslpikamvksLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLqANLRDSGILSALPFMFGC 337
Cdd:cd17380  177 -----------------------------PPVWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMF 226

                        250       260
                 ....*....|....*....|....*....
gi 568981872 338 VCIILGGLLADFLLSRKIlRLVTIRKLFT 366
Cdd:cd17380  227 PSSNVAGWLADHLISRGW-TVTSVRKLMQ 254
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
98-356 7.59e-26

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 107.26  E-value: 7.59e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  98 YDWTPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAAdaGVALLIVLRVIQGMAQVMVLT 177
Cdd:COG2271   40 LGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFP 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 178 GQYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGcaccLLWFPlvyddpqnhpfist 257
Cdd:COG2271  118 AALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPG----LLLAL-------------- 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 258 gerryitcslaqedcslgwslpikamvksLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGC 337
Cdd:COG2271  180 -----------------------------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGI 230

                        250
                 ....*....|....*....
gi 568981872 338 VCIILGGLLADFLLSRKIL 356
Cdd:COG2271  231 VGSLLGGWLSDRLGRRRKL 249
MFS_1 pfam07690
Major Facilitator Superfamily;
98-373 2.75e-25

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 105.58  E-value: 2.75e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872   98 YDWTPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAAdaGVALLIVLRVIQGMAQVMVLT 177
Cdd:pfam07690  27 LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS--SLWLLLVLRVLQGLGAGALFP 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  178 GQYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFpLVYDDPQNHPFIST 257
Cdd:pfam07690 105 AALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLL-LPRPPPESKRPKPA 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  258 GERRYITcslaqedcslgwSLPIKAMVKSLPLWAIVVSyFCEYWLLSTVMAYTPTYIsSVLQANLRDSGILSALPFMFGC 337
Cdd:pfam07690 184 EEARLSL------------IVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGA 249

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 568981872  338 VCIILGGLLADFLLSRKILRLVTIRKLFTAGSLPHL 373
Cdd:pfam07690 250 IGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLL 285
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 100-370 4.99e-24

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 102.26  E-value: 4.99e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 100 WTPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAAdaGVALLIVLRVIQGMAQVMVLTGQ 179
Cdd:cd17319   35 LSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFAT--SLTSLYVLRFLLGVAEAGFFPGA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 180 YSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLVYDdpqnhpfistge 259
Cdd:cd17319  113 IKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ------------ 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 260 rryitcslaqedcslgwslpikamvkslpLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVC 339
Cdd:cd17319  181 -----------------------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIG 231

                        250       260       270
                 ....*....|....*....|....*....|.
gi 568981872 340 IILGGLLADFLLSRKILRLVTIRKLFTAGSL 370
Cdd:cd17319  232 MILGGRLSDRLLRGARRLVIIIGLLLAAVGL 262
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
98-358 6.05e-20

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 90.42  E-value: 6.05e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  98 YDWTPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADagVALLIVLRVIQGMAQVMVLT 177
Cdd:COG2814   40 LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPS--LWLLLAARFLQGLGAGALFP 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 178 GQYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLVyddPQNHPFIST 257
Cdd:COG2814  118 AALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLL---PESRPAARA 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 258 GERRyitcslaqedcslgwslPIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGC 337
Cdd:COG2814  195 RLRG-----------------SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGV 257

                        250       260
                 ....*....|....*....|.
gi 568981872 338 VCIILGGLLADFLLSRKILRL 358
Cdd:COG2814  258 LGALLAGRLADRFGRRRLLLI 278
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 97-356 2.03e-19

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 89.02  E-value: 2.03e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  97 VYDWTPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADagVALLIVLRVIQGMAQVMVL 176
Cdd:cd06174   25 SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPS--FWLLLLGRFLLGLGSGLID 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 177 TGQYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQAL--GWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPF 254
Cdd:cd06174  103 PAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAALALLAAILLLLVVPDPPESARA 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 255 IStgerryitcslaQEDCSLGWSLPIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFM 334
Cdd:cd06174  183 KN------------EEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGL 250

                        250       260
                 ....*....|....*....|..
gi 568981872 335 FGCVCIILGGLLADFLLSRKIL 356
Cdd:cd06174  251 AGALGSLLLGLLSDRLIGRKPL 272
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
98-361 8.19e-18

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 84.55  E-value: 8.19e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  98 YDWTPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADagVALLIVLRVIQGMAQVMVLT 177
Cdd:COG2223   35 FGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVS--YWLLLLLGLLLGIGGGGSFA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 178 GQYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFIST 257
Cdd:COG2223  113 VGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAK 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 258 GERRyitcslaqedcslgwslPIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGC 337
Cdd:COG2223  193 ASLR-----------------DQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGA 255

                        250       260
                 ....*....|....*....|....
gi 568981872 338 VCIILGGLLADFLLSRKILRLVTI 361
Cdd:COG2223  256 LGRPLGGWLSDRIGGRRVLLIVFA 279
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 106-361 1.31e-16

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 80.70  E-value: 1.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 106 GILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADagVALLIVLRVIQGMAQVMVLTGQYSLWAK 185
Cdd:cd17325   34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATS--YWQLLLARFLQGLASAAVWPAAMALIAD 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 186 WAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPfistgerryitc 265
Cdd:cd17325  112 IAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPN------------ 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 266 slAQEDCSLGWSLPIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGL 345
Cdd:cd17325  180 --KRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGK 257

                        250
                 ....*....|....*.
gi 568981872 346 LADFLLSRKILRLVTI 361
Cdd:cd17325  258 LSDRIGRKPLILIGLL 273
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 106-354 2.16e-14

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 73.95  E-value: 2.16e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  106 GILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFipLAADAGVALLIVLRVIQGMAQVMVLTGQYSLWAK 185
Cdd:TIGR00881  33 GLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLF--FGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTK 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  186 WAPPQERSQLITIAASGSML-GTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFISTGERR--Y 262
Cdd:TIGR00881 111 WFSRSERGTWVSFWNCSHNVgGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPAEEMPneE 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  263 ITCSLAQ-EDCSLGWSLPIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCII 341
Cdd:TIGR00881 191 PDGDAEKkEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTL 270

                         250
                  ....*....|...
gi 568981872  342 LGGLLADFLLSRK 354
Cdd:TIGR00881 271 LAGWLSDKLFNGR 283
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 101-352 1.74e-13

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 70.61  E-value: 1.74e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 101 TPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAAdaGVALLIVLRVIQGMAQVMVLTGQY 180
Cdd:COG0477   47 SSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAP--SPELLIAARALQGIGAGGLMPGAL 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 181 SLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGcaccLLWFPLVYDDPQNHPFISTGER 260
Cdd:COG0477  125 ALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLG----LLALVLRLRLPESRGLLLALLA 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 261 RYITCSLAQEDCSLGWSLPIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCI 340
Cdd:COG0477  201 LALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLL 280

                        250
                 ....*....|..
gi 568981872 341 ILGGLLADFLLS 352
Cdd:COG0477  281 LLLLLLLLLLLA 292
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 108-413 3.30e-12

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 67.66  E-value: 3.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 108 LLSSLSYGSFI-APIPTGYVAGVFGAKYVVGLGLLISSVLTLFipLAADAGVALLIVLRVIQGMAQVMVLTGQYSLWAKW 186
Cdd:cd17327   45 WGNTVFYVGYIiFELPGNLLLQRFPPSKWLSVFIVLWGLLTLL--TAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMW 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 187 APPQERSQLITIAASGSMLGTflvlIAGGLICQAL----------GWPYIFYIFGGIGCAC---CLLWFPlvyDDPQNHP 253
Cdd:cd17327  123 YKREEQAKRIAFFYAAAGLGS----IFGGLLAYGVfkilgvgglaGWRWLFIIEGLITIIIglvIFFWLP---DNPSKAW 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 254 FISTGERRYITCSLAQEDCSLG-----WSLPIKAMvKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISS----VLQANLrd 324
Cdd:cd17327  196 FLTEEEKELAVERLRANQTGKGdqkfkWKQIKEAF-KDPRTWLLFLFFFCSQITNNGISNFLPLILKSlgfySLQTNL-- 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 325 sgiLSALPFMFGCVCIILGGLLADFLLSRKIlrlvtirkLFTAGSLPHLESSCPCLGSDLAAAPQWPSWYCLLSLPASVi 404
Cdd:cd17327  273 ---LSVPIGALGAVSLLIAALLSDRFKKRGL--------FAIFACVLALVGSIILLAAPNPPGAYFAAYILGGGSYAGF- 340


                 ....*....
gi 568981872 405 qePSLTSWI 413
Cdd:cd17327  341 --PILLSWI 347
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 106-356 1.70e-11

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 65.26  E-value: 1.70e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 106 GILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADAGValLIVLRVIQGMAQVMVLTGQYSLWAK 185
Cdd:cd17324   37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFAL--LLLARALAGLAHGGFWAIAAAYAAD 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 186 WAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFistgerryitc 265
Cdd:cd17324  115 LVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPG----------- 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 266 slaqedcSLGWSLPIKAMVKSLPLWAIVVSYFCeyWLLSTVMAYtpTYISSVLQANLR-DSGILSALPFMFGCVCII--- 341
Cdd:cd17324  184 -------SLGLLSSLLLLLRNPRLRLAYLITFL--LFGGFFALY--TYLAPFLTDVPGfSSSAIIGLLLLFGVAGVVgsp 252

                        250
                 ....*....|....*
gi 568981872 342 LGGLLADFLLSRKIL 356
Cdd:cd17324  253 LAGRLADRGGRRALL 267
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 118-350 8.98e-10

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 59.94  E-value: 8.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 118 IAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADagVALLIVLRVIQGMAQVMVLTGQYSLWAKWAPPQERSQLIT 197
Cdd:cd17328   49 VLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPN--FWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALG 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 198 IAASGSMLGTFLVLIAGGLICQA-LGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHpfISTGERRYITCSLAQEDcslgw 276
Cdd:cd17328  127 VFYFAIPLGSGLGYVVGGLVAQAtGGWRWAFRVTGVLGVLLAILLLLFVREPPRGA--AEGGVMAKSTATSFLAD----- 199

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568981872 277 slpIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANL----RDSGILSALPFMFGCVCIILGGLLADFL 350
Cdd:cd17328  200 ---LKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDlssaDVGLIFGAITCIAGVLGVLLGGILADRL 274
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
138-370 1.31e-09

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 59.53  E-value: 1.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 138 LGLLISSVLTLFIPLAADAG----VALLIVLRVIQGMAQVMVLTGQYSLWAKWAP-PQERSQLITIAASGSMLGTFLVLI 212
Cdd:COG2211   86 IGAIPLALSFVLLFTAPDLSptgkLIYALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASV 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 213 AGGLI------CQALGWPYIFYIFGGIGCACCLLwfplvyddpqnhPFISTGERRYITCSlaqedcslgwSLPIKAMVKS 286
Cdd:COG2211  166 LPPPLvaafggDAALGYRLTALIFAVLGLLAFLL------------TFFGTKERPVPEEE----------KVSLKESLKA 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 287 L----PLWAIVVSYFCeYWL-LSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGLLADFLLSRKILRLVTI 361
Cdd:COG2211  224 LlknrPFLLLLLAYLL-FFLaLALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLL 302


                 ....*....
gi 568981872 362 rkLFTAGSL 370
Cdd:COG2211  303 --LAALGLL 309
2_A_01_02 TIGR00880
Multidrug resistance protein;
106-243 1.37e-09

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 56.12  E-value: 1.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  106 GILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTlfIPLAADAGVALLIVLRVIQGMAQVMVLTGQYSLWAK 185
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLST--AMFALSSNITVLIIARFLQGFGAAFALVAGAALIAD 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568981872  186 WAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYI---FGGIGCACCLLWFP 243
Cdd:TIGR00880  79 IYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFlaiLALAAFILLAFLLP 139
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 97-242 7.94e-09

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 56.82  E-value: 7.94e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  97 VYDWTPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAadAGVALLIVLRVIQGMAQVMVL 176
Cdd:cd17325  229 LGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLA--TSFWLLLLLLALLGLGLGLVF 306

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568981872 177 TGQYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIgCACCLLWF 242
Cdd:cd17325  307 PATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAAL-LLLAAVLF 371
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 101-321 1.16e-08

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 56.45  E-value: 1.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 101 TPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAAdaGVALLIVLRVIQGMAQVMVLTGQY 180
Cdd:cd17489   29 SEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT--SVALLLVLRLIHGIGWGAFTTAAA 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 181 SLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFpLVYDDPQNHPFISTGER 260
Cdd:cd17489  107 TLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVF-LVKDPPPVAAEEAEAGT 185

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568981872 261 RyitcslaqedcSLGWSLPIKAMVKSLPLWAIVVSYfceywllSTVMAYTPTYISSVLQAN 321
Cdd:cd17489  186 R-----------AFRRLVEKKVLPPALILFLASIAY-------GAISTFLPLYAAERGISN 228
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 97-244 1.43e-08

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 56.08  E-value: 1.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  97 VYDWTPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADagVALLIVLRVIQGMAQVMVL 176
Cdd:cd06173  238 VLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPS--LWLLLAALFLLGLAGGLFN 315

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568981872 177 TGQYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPL 244
Cdd:cd06173  316 VPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 111-240 1.48e-08

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 56.03  E-value: 1.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 111 SLSYGSFIapIPTGYVAGVFGAK--YVVGLGL-LISSVLTLFIPlaadaGVALLIVLRVIQGMAQVMVLTGQYSLWAKWA 187
Cdd:cd17321   41 LLAFAALL--LLAGRLGDRFGRKrvFLIGLALfGLASLLCALAP-----SLAFLIAARALQGIGAAAIMPASLALIAATF 113

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568981872 188 PPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLL 240
Cdd:cd17321  114 PGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLL 166
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
97-245 3.45e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 54.88  E-value: 3.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  97 VYDWTPEIQGILLSSLSYGSFIAPIPTGYVAGVFGA--KYVVGLGLLISSVLTLFIPLAADAGVALLIVlrVIQGMAQVM 174
Cdd:COG2271  210 VRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALL--FLAGFGLGG 287

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568981872 175 VLTGQYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLV 245
Cdd:COG2271  288 AFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 121-240 1.31e-07

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 53.35  E-value: 1.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 121 IP-TGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADAGValLIVLRVIQGMAQ-VMVLTGQySLWAKWAPPQERSQLITI 198
Cdd:cd17503   48 IPlSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLAS--LIIFRILQGFGGgVLIPLAQ-TILLRIYPPEKRGAAMGL 124

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 568981872 199 AASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLL 240
Cdd:cd17503  125 VGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLL 166
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 111-347 1.43e-07

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 53.03  E-value: 1.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 111 SLSYGSFIapIPTGYVAGVFGAK--YVVGLGLL-ISSVLTLFIPlaadaGVALLIVLRVIQGMAQVMVLTGQYSLWAK-W 186
Cdd:cd17476   43 SLTVGTFI--LIFGRLGDIYGHKkmFVIGSFWFaIWSLIAGFSP-----NFIFFIICRALQGLGPAFLLPNAMALLGRtY 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 187 APPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFgGIGCACC----LLWFplvyddpqnhpfistgeRRY 262
Cdd:cd17476  116 PPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFL-AILAAIVavaaIFWT-----------------SPS 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 263 ITCSLAQedCSLGWSlpikamvkSLPLWAIVVSYFCE----YWLLSTVMAYTPTYISSVLqANLRDSGILSALP----FM 334
Cdd:cd17476  178 FIAVLLA--VFLGWA--------SFGIWVFYATQYFQnvrgYSPLLTSARFIPMAIGGVL-AAITVGFLIARLPpsyiMA 246

                        250
                 ....*....|...
gi 568981872 335 FGCVCIILGGLLA 347
Cdd:cd17476  247 ISMVAFLVGPILF 259
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
106-361 1.63e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 52.93  E-value: 1.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 106 GILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAadAGVALLIVLRVIQGMAQVMVLTGQYSLwAK 185
Cdd:COG0738   46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALA--PSYPLLLLALFLLGLGLGLLDVAANPY-VA 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 186 WAPPQERSQLITIAASGSMLGTFLV-LIAGGLICQALG--WPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFISTGERRy 262
Cdd:COG0738  123 ALGPETAASRLNLLHAFFSLGALLGpLLGGLLILLGLSlsWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAA- 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 263 itcslaqedcslgwslPIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIIL 342
Cdd:COG0738  202 ----------------SLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFL 265

                        250
                 ....*....|....*....
gi 568981872 343 GGLLADFLLSRKILRLVTI 361
Cdd:COG0738  266 GGFLLKRFGPVRLLRLSAL 284
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 106-408 2.45e-07

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 52.32  E-value: 2.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 106 GILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLtlFIPLAADAGVALLIVLRVIQGMAQVMVLTGQYSLWAK 185
Cdd:cd17333   34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLA--LALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGA 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 186 WAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLVYDDPqnhpfistgERRYITC 265
Cdd:cd17333  112 LFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAILILLTLFPEL---------PSARNPQ 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 266 SLAQEDcslgwSLPIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGL 345
Cdd:cd17333  183 QSVGAF-----SASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGP 257

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568981872 346 LADFLLSRKILRLVTIRKLFT------AGSLPHLESSCPCLGsdLAAAPQWPswyCLLSLPASVIQEPS 408
Cdd:cd17333  258 ISRRIKPHTLLVLSGSGALLGllilllAPTLVVGLVATALLG--LFMAALFP---TILSLGISNLPYAK 321
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 106-356 1.50e-06

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 49.88  E-value: 1.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 106 GILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADagVALLIVLRVIQG------MAQVMVLTGQ 179
Cdd:cd17474   37 GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDS--FALLLAGRALQGigaaglGPLALTLIGD 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 180 YSlwakwaPPQERSQLITIAASGSMLGTFLVLIAGGLICqALGWPYIFYIFGGIGCACCLLWFPLVYDDPqnhpfiSTGE 259
Cdd:cd17474  115 LF------EGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAALIPVAFLAILFLLPEPK------EKAK 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 260 RRYITCSLAQedcslgwslpiKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCV- 338
Cdd:cd17474  182 SSSATKLRDL-----------KKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALg 250

                        250
                 ....*....|....*...
gi 568981872 339 CIILGGLLADFLLSRKIL 356
Cdd:cd17474  251 SLFVGRLLKKRFGARRIL 268
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
 111-261 1.92e-06

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 49.61  E-value: 1.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 111 SLSYGSFIAPIP-TGYVAGV---------FGAKYVVGLGLLISSVLTLFIPLAAdaGVALLIVLRVIQGMAQVMVLTGQY 180
Cdd:cd06180   32 SYAQAGWIATANyAGYLVGAllasflrrrGRARRLIRGGLLLTVLLLAAMALTS--GFAALLALRFLAGAASAFVFVFGS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 181 SLWAKWAPPQERSQLITIAASGSMLGTFL--VLIAGGLIcQALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFISTG 258
Cdd:cd06180  110 NLVLHHATAAGRGHLIGLLFAGVGLGIALsgLLVPAGLG-GGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEASAA 188


                 ...
gi 568981872 259 ERR 261
Cdd:cd06180  189 ESA 191
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
 121-361 2.76e-06

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 49.17  E-value: 2.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 121 IPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAAdAGVALLIVLRVIQGMAQVMVLTGQYSLwAKWAPPQERSQLITIAA 200
Cdd:cd17341   52 LPYGFLCDRFGGRRVFIASLLLLLIPLLALALAV-SSYWGLLVLGFLLGFAGANFASGQPWA-SFWFPKEKIGGAAGGIA 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 201 SGSMLGT-----FLVLIAGGLICQ--ALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNhpfistgeRRYITCSLAQedcs 273
Cdd:cd17341  130 GAGNMGVavsqlLAPLIAGAIVFDggFVGWRNAFFVPGILLAIAAVLVLLFGDDLPTG--------KASALEFLKV---- 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 274 lgwslpIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGLLADFLLSR 353
Cdd:cd17341  198 ------QLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGR 271


                 ....*...
gi 568981872 354 KILRLVTI 361
Cdd:cd17341  272 RRLWWLFI 279
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 106-249 4.60e-06

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 48.42  E-value: 4.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 106 GILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFipLAADAGVALLIVLRVIQGMAQVMVLTGQYSLWAK 185
Cdd:cd17312   41 GIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIF--MGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGN 118

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568981872 186 WAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLVYDDP 249
Cdd:cd17312  119 WFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSP 182
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 118-245 1.26e-05

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 46.80  E-value: 1.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 118 IAPIPTGYVAGVFGAKYVVGLGLLISSVLTlfIPLAADAGVALLIVLRVIQGMAQVMVL-TGQYSLwAKWAPPQERSQLI 196
Cdd:cd17323   49 LGPLIWAPLSELYGRRPVYLVSLFIFVIFQ--IGCALAPNIAMLIILRFLQGFFGSSPLaIGAGTI-ADLFTPEERGKAM 125

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568981872 197 TIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCAC---CLLWFPLV 245
Cdd:cd17323  126 GVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFClilIFLFLPIV 177
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 106-370 1.79e-05

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 46.46  E-value: 1.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 106 GILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVltLFIPLAADAGVALLIVLRVIQGMAQVMVLTGQYSLWAK 185
Cdd:cd17475   34 GLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGA--AALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMR 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 186 WAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFyIFGGIGCACCLLWFPLVYDDPQN---HPFISTGERRy 262
Cdd:cd17475  112 WFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAF-VVAGLVSILAAVLFWLFYREPPAasaATESASTLLR- 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 263 itcslaqedcslgwslPIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIIL 342
Cdd:cd17475  190 ----------------SLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIG 253

                        250       260
                 ....*....|....*....|....*...
gi 568981872 343 GGLLADFLLSRKILRLVTIRKLFTAGSL 370
Cdd:cd17475  254 LGRVSDRVFGGRRRPVLVITAAIAAAAL 281
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 121-252 3.91e-05

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 45.83  E-value: 3.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  121 IP-TGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADagVALLIVLRVIQGMAQVMVLTGQYSLWAKWAPPQERSQLITIA 199
Cdd:TIGR00711  54 IPlTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPN--LELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIW 131

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568981872  200 ASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLL-WFPLVYDDPQNH 252
Cdd:TIGR00711 132 GLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVaFFILPRDKPAAS 185
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 189-349 6.92e-05

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 44.90  E-value: 6.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 189 PQERSQLITIAASGSMLGTFLVLIAGGLI-------CQALGWPYIFYIFGGIGCaCCLLWFplvyddpqnhpFISTGERR 261
Cdd:cd17332  131 PEERTSLTSWRMFFATIGGLLVTVLPPPLvayfgggNASRGYFLTALIIGIIGI-ILLLIC-----------FFGTRERV 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 262 YITcslAQEDCSLGWSLPIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCII 341
Cdd:cd17332  199 VPP---EEEKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLP 275


                 ....*...
gi 568981872 342 LGGLLADF 349
Cdd:cd17332  276 WPPLKKRF 283
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
97-206 9.96e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 44.19  E-value: 9.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  97 VYDWTPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAadAGVALLIVLRVIQGMAQVMVL 176
Cdd:COG2814  237 VLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALA--GSLWLLLLALFLLGFGFGLLF 314

                         90       100       110
                 ....*....|....*....|....*....|
gi 568981872 177 TGQYSLWAKWAPPQERSQLITIAASGSMLG 206
Cdd:COG2814  315 PLLQALVAELAPPEARGRASGLYNSAFFLG 344
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 101-242 1.42e-04

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 43.53  E-value: 1.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  101 TPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADAGValLIVLRVIQGMAQVMVLTGQY 180
Cdd:TIGR00710  38 PASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIET--LLVLRFVQAFGASAGSVISQ 115

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568981872  181 SLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWF 242
Cdd:TIGR00710 116 ALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIF 177
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 106-355 1.47e-04

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 43.75  E-value: 1.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 106 GILLSSLSYGSFIAPIPTGYVAGVFGA-KYVVGLGLLISSVLTLFIPLAADagVALLIVLRVIQGMAQVM--VLTgqySL 182
Cdd:cd17490   34 GIILGAYGISQMLLRIPLGILSDRIGKrKLFIIIGLLFTVLASLIMILFPS--PWGLLIARFLSGIAAATwvSFT---VL 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 183 WAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFISTGERry 262
Cdd:cd17490  109 YASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLTELKE-- 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 263 itcslaqedcslgwslpIKAMVKSLPLWAI-VVSYFCEYWLLSTVMAYTPTYISSvLQANLRDSGILSALPFMFGcvciI 341
Cdd:cd17490  187 -----------------LLSVLKDKKLLFFsLLAILQQMITFSTTFGFTPLIAKQ-LGASSFQLGLLSIIYLLPN----A 244

                        250
                 ....*....|....
gi 568981872 342 LGGLLADFLLSRKI 355
Cdd:cd17490  245 LASLLSGTLFYKKL 258
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 106-233 2.24e-04

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 43.11  E-value: 2.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  106 GILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADagVALLIVLRVIQG------MAQVMVLTGQ 179
Cdd:TIGR00895  55 GFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATN--VTQLLILRFLAGlglgglMPNLNALVSE 132

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568981872  180 YslwakwAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIfGGI 233
Cdd:TIGR00895 133 Y------APKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYV-GGI 179
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 97-244 2.42e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 42.94  E-value: 2.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  97 VYDWTPEIQGILLSSLSYGSFIAPIPTGYVAGV-FGAKYVVGLGLLISSVLTLFIPLAADagVALLIVLRVIQGMAQVMV 175
Cdd:cd17474  228 LYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPS--LALLLIAIVLFGLGLGLN 305

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568981872 176 LTGQYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPL 244
Cdd:cd17474  306 LPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 106-361 2.92e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 42.60  E-value: 2.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 106 GILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADagVALLIVLRVIQGMAQVMVLTGQYSLWAK 185
Cdd:cd17329   38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHS--PWLFAIALVLTGFGGGLFEPASEAMIAD 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 186 WAPPQERSQLITI--------AASGSMLGTFLVLIAGGLICQALGWPYIFYIFggigcaCCLLWFPLVYDDPQNHPFIST 257
Cdd:cd17329  116 VTTPENRTRAFSLlywainlgVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAAL------VLLFLLPETRPKRRAAEKTEI 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 258 GErryitcslaqedcslgwslPIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPfmfGC 337
Cdd:cd17329  190 LR-------------------GYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALN---AL 247

                        250       260
                 ....*....|....*....|....
gi 568981872 338 VCIILGGLLADFLLSRKILRLVTI 361
Cdd:cd17329  248 LIVLLQFPVARLVERFRLRKILMI 271
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
 101-386 3.45e-04

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 42.36  E-value: 3.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 101 TPEIQGILLSSLSYGS--FIAP---IPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLA---ADAGVA---LLIVLRVIQG 169
Cdd:cd17368   33 GSEFASLLLTFATFGVgfFMRPigaIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAptyATIGIAaplLVLLARLLQG 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 170 MAQVMVLTGQYSLWAKWAPPQER---------SQLITIAAsGSMLGTFLVLIAGGLICQALGWPYIFYIfgGIGCACCLL 240
Cdd:cd17368  113 FAAGGEVGGVTAYLVEAAPPGRRgfytswqsaSQQVAIVA-GALVGYLLSLTLTAEALAEWGWRIPFFI--GLLIIPLGL 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 241 WFPLVYDDPQNHP-FISTGERRYITCSLAQEDCSLGWSLPIKAMvkslplwAIVVSYFCEYwllstvmaYTPTYISSVLQ 319
Cdd:cd17368  190 WLRRSLEETEAFLeRKARPTRRELFALLANNRRIILLGMLLVAG-------STVTFYFTTV--------YTPTYAKTVLG 254

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568981872 320 ANLRDSGILSALPFMFGCVCIILGGLLADFLLSRKILRLVTIRKLFTAGSLPHLESSCPCLGSDLAA 386
Cdd:cd17368  255 LSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFAWLTAAPSFGRLLLV 321
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 124-245 3.63e-04

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 42.19  E-value: 3.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 124 GYVAGVFGAKYVVGLGLLISSVLTLFIPLAADagVALLIVLRVIQGMAQVMVLTGQYSLWAKWAPPQERSQLITIAASGS 203
Cdd:cd17365   55 GPLADRFGRKRVLLVSVALFGLFTLLTAFAQS--VLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGY 132

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 568981872 204 MLGTFLVLIAGGLICQALGWPYIFYIFGGIGcaccLLWFPLV 245
Cdd:cd17365  133 PLGAALGGFLAAALIPAFGWRSVFLLGGVPP----LILLPLL 170
Sugar_tr pfam00083
Sugar (and other) transporter;
87-241 5.06e-04

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 42.26  E-value: 5.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872   87 NETLQESKAPVYDWTPEiQGILLSSLSYGSFIAPIPTGYVAGVFGAKY---VVGLGLLISSVLTLFIPLAAdaGVALLIV 163
Cdd:pfam00083  31 NFGLSKSVSSLAALSVL-SGLIVSIFSVGCFIGSLFAGKLGDRFGRKKsllIANVLFVIGAVLQGAAKGKW--SVYQLIV 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  164 LRVIQGMAqVMVLTGQYSLW-AKWAPPQERSQLITIAASGSMLGTFLVLIAG---GLICQALGWPYIFY---IFGGIGCA 236
Cdd:pfam00083 108 GRVLVGIG-VGGASVLAPMYiSEIAPKKLRGALGSLYQLAITFGILLAYIFGlglNKTSNSDGWRIPLGlqlVPALLLII 186


                  ....*
gi 568981872  237 CCLLW 241
Cdd:pfam00083 187 GLLFL 191
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
 98-250 5.55e-04

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 41.84  E-value: 5.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  98 YDWTPEIQGILLS--SLSYGsfIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIP--LAADAGVALLIVLRVIQGMAQV 173
Cdd:cd17345   33 YGLSKTEIGLIGSalSIAYG--LSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGfvPSATSSVGLMFILLFLNGWFQG 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 174 MVLTGQYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALG---WPYIFYIFGGIGCACCLLWFPLVYDDPQ 250
Cdd:cd17345  111 MGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGdgwWRGAFIFPAIIAIIVAVIVLFLGKDTPE 190
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 161-237 5.60e-04

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 41.78  E-value: 5.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 161 LIVLRVIQGMAQVMVLTGQYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYI---FGGIGCAC 237
Cdd:cd17502   86 LIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYInlpIGGLALAL 165
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 117-353 6.05e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 41.79  E-value: 6.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 117 FIAPIpTGYVAGVFGAKYVVGLGLLISSVLTLfIPLAADAgVALLIVLRVIQGMAQVMVLTGQYSLWAKWAPPQERSQLI 196
Cdd:cd17473   50 LFAPL-AGWLADRFGRKRLLIAGLLLYGIGGV-AGLFLDS-LYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKML 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 197 -TIAASGSMLGTFLVLIAGGLIcqALGWPYIFYIFG-GIGCACCLLWFplVYDDPQNHPFISTGerryitcslaqedcsl 274
Cdd:cd17473  127 gLQSAAMSLGGVVFLLLGGALA--EIGWRAPFLVYLlALPVLILVLLF--LPEPARKSKSAASP---------------- 186

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568981872 275 gwSLPIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGcvciILGGLLADFLLSR 353
Cdd:cd17473  187 --GAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAG----AIGALLFGRLKRR 259
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 100-356 6.56e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 41.43  E-value: 6.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 100 WTPEIQGILLSSLSY-GSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAAdaGVALLIVLRVIQGMAQVMVLTG 178
Cdd:cd17316   32 GLSLLQTGLLFAAGFlGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLP--TPILLLVLRFLQGIGIGGEYPG 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 179 QYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLI----CQALGWPyIFYIFGGIGCACCLLWfplvyddpqnhpf 254
Cdd:cd17316  110 ASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLipllSGDWGWR-ILFLIGALPALLALLL------------- 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 255 istgeRRYItcslaqedcslgwslpikamvkslplWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFM 334
Cdd:cd17316  176 -----RRRT--------------------------LLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISL 224

                        250       260
                 ....*....|....*....|..
gi 568981872 335 FGCVCIILGGLLADFLLSRKIL 356
Cdd:cd17316  225 GALVGALIAGLLSDRIGRKKTL 246
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
118-353 9.48e-04

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 41.01  E-value: 9.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 118 IAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFipLAADAGVALLIVLRVIQGMAQVM---VLTGqyslWAKWAPPQERSQ 194
Cdd:COG2807   68 LFAPLAPRLARRFGLERTLLLALLLLAAGLLL--RSLAPSVALLLAGTALIGAGIAVgnvLLPG----LIKRWFPDRVGL 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 195 LITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFISTGERRyitcslaqedcsl 274
Cdd:COG2807  142 MTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASL------------- 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 275 gwslpiKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYissvlqanLRDSGI---LSALPFMFGCVCIILGGLLADFLL 351
Cdd:COG2807  209 ------RSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPI--------LRDAGLsaaTAGLLLSLFQLAGIPGSLLVPLLA 274


                 ..
gi 568981872 352 SR 353
Cdd:COG2807  275 DR 276
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 106-209 2.47e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 39.82  E-value: 2.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 106 GILLSSLSYG-SFIAPIPTGYVAGVFGAKY------VVGLGLL-ISSVLTLFIPLAADAGVA---LLIVLRVIQGMAqvm 174
Cdd:cd17369   42 GTLAAFATFGvGFLARPLGGVVFGHFGDRIgrkktlVLTLLLMgIATFLIGLLPTYAQIGILapiLLVLLRLLQGLA--- 118

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 568981872 175 vLTGQYS----LWAKWAPPQERSQLITIAASGSMLGTFL 209
Cdd:cd17369  119 -LGGEWGgavlMAVEHAPPKRRGFYGSFPQLGAPVGLLL 156
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 104-229 2.87e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 39.56  E-value: 2.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 104 IQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLtlFIPLAADAGVALLIVLRVIQGMAQVMVLTGQYSLW 183
Cdd:cd17391  241 ISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALL--YIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLL 318

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 568981872 184 AKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYI 229
Cdd:cd17391  319 AKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVV 364
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
97-242 4.81e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 38.71  E-value: 4.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  97 VYDWTPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYV---VGLGLLISSVLTLFIPLAADAGVALLIVLRVIQGMAQV 173
Cdd:COG2223  235 QFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVlliVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNG 314

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 174 MVltgqYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALG-WPYIFYIFGGIGCACCLLWF 242
Cdd:COG2223  315 AV----FALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTL 380
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 100-233 5.30e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 38.71  E-value: 5.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 100 WTPEIQGILLSSLSYGSFIAPIP-TGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADagVALLIVLRVIQGMAQVMVLTG 178
Cdd:cd17330  207 FSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASS--VPLLVLAAAILAFGTGIVFPA 284

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568981872 179 QYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGwPYIFYIFGGI 233
Cdd:cd17330  285 LSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLG-PGVPFLLAAG 338
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 106-242 6.05e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 38.71  E-value: 6.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 106 GILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADAGVALLIVlrVIQGMAQVMVLTGQYSLWAK 185
Cdd:cd17473  236 GLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGA--ILAGLGFGLLLPTLNSWAMS 313

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568981872 186 WAPPQERSQLITIAASGSMLGTFLV-LIAGGLICQALGWPYIFYIFGGIGCACCLLWF 242
Cdd:cd17473  314 LVPPELRGRAMGIVTSAFFLGQFLSpLVLGPLVNLTGGLSGAFLILGVLALVLAIVLL 371
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 97-177 6.52e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 38.31  E-value: 6.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872  97 VYDWTPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSV-LTLFIPLAADAGVALLIVLRVIQGMAQVMV 175
Cdd:cd17321  198 VLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVgLLLLALLGADSSVWLLLPGLVLLGLGLGLF 277


                 ..
gi 568981872 176 LT 177
Cdd:cd17321  278 AT 279
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 106-240 9.72e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 37.95  E-value: 9.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981872 106 GILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVlTLFIPLAADAGVALLIVLRVIQGMAQVMVLTGQYSLWAK 185
Cdd:cd17365  209 LTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAV-SLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAAR 287

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 568981872 186 WAPPQERSQLITIAASGSMLGTFL-VLIAGGLICQALGWPYIFYIFGGIGCACCLL 240
Cdd:cd17365  288 FYPTEVRATGVGWALGVGRLGAILgPLLGGLLLAAGLGPESVFLALAIPAALGALA 343
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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