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Conserved domains on  [gi|568987880|ref|XP_006519173|]
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RING finger protein 17 isoform X4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tudor_TDRD4_rpt2 cd20415
second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 728-823 2.37e-50

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410486  Cd Length: 96  Bit Score: 172.62  E-value: 2.37e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  728 FLSLLKTIEEFYKGEDGENLEILCPLQNQACVAKFEDGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEFL 807
Cdd:cd20415     1 FLILTKKIQEFYKEGDDGGLEILCPVQGQACVALFEDGAWYRARIIGLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFL 80

                          90
                  ....*....|....*.
gi 568987880  808 EPPEKAIKCKLAYVEP 823
Cdd:cd20415    81 SLPEKARECRLAFIEP 96
Tudor_TDRD4_rpt3 cd20416
third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 968-1049 6.21e-38

third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410487  Cd Length: 82  Bit Score: 136.46  E-value: 6.21e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  968 LEEKMVAAYEHSEWKPVKWECDMHCAVKVPAKNQWRRGQILRMVTDKLVEVLLYDVGVELVVNIHCLRELQENLKTMGRL 1047
Cdd:cd20416     1 LQEKMIAEYENSKPEPVKWENDMHCAVQIQDKKQWRRGQIIRVVSDTLVEVFLYDFGNKEVVNIDCLRKLEENLKTIGKL 80


                  ..
gi 568987880 1048 SL 1049
Cdd:cd20416    81 AL 82
Tudor_TDRD4_rpt1 cd20414
first Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 490-565 4.29e-30

first Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410485  Cd Length: 77  Bit Score: 113.84  E-value: 4.29e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568987880  490 ELGARIFVNSIKNRMWCRGIITEIIPSKTKNIRKPCSPTKFSVCEISLIQIFMVDFGNSEVLIITGVGDTHEGPEH 565
Cdd:cd20414     1 ELGERIAVKSKKNGMWCRGTITELIPLENKNKGKPCGPTRYKIHDVAVMQVFLLDYGHSEVFVVTGVGVLVVRPED 76
CC_brat-like super family cl29238
coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins; This family ...
 158-242 1.69e-04

coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins; This family contains the coiled-coil (CC) region of Drosophila brain tumor (Brat), a translational repressor that belongs to the tripartite motif (TRIM) protein superfamily. TRIM proteins play important roles in various cellular processes and are involved in many diseases which consists of two B-box domains and a coiled-coil (CC) domain at the N-terminal region, and an NHL domain at the C-terminus. Brat localizes at the basal cortex during asymmetric division of Drosophila neuroblasts by directly interacting with the scaffolding protein Miranda (Mira), which it does through the CC-NHL domain tandem, indicating that the function of the Brat CC domain is to assemble Brat-NHL in dimeric form which is necessary for Mira binding. Brat CC forms an elongated antiparallel dimer similar to its other TRIM protein counterparts, but the overall length of Brat CC dimer is shorter than the TRIMs.


The actual alignment was detected with superfamily member smart00502:

Pssm-ID: 475168  Cd Length: 127  Bit Score: 42.64  E-value: 1.69e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880    158 EQLSNAIKMLDSTQDQTRQETHSLTEAVEKQFDTLLASLDSRKKSLCEELIRRTDDYLSKLVTVKSYIEEKKSDLDAAMK 237
Cdd:smart00502   17 AELEDALKQLISIIQEVEENAADVEAQIKAAFDELRNALNKRKKQLLEDLEEQKENKLKVLEQQLESLTQKQEKLSHAIN 96


                    ....*
gi 568987880    238 IAKEL 242
Cdd:smart00502   97 FTEEA 101
 
Name Accession Description Interval E-value
Tudor_TDRD4_rpt2 cd20415
second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 728-823 2.37e-50

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410486  Cd Length: 96  Bit Score: 172.62  E-value: 2.37e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  728 FLSLLKTIEEFYKGEDGENLEILCPLQNQACVAKFEDGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEFL 807
Cdd:cd20415     1 FLILTKKIQEFYKEGDDGGLEILCPVQGQACVALFEDGAWYRARIIGLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFL 80

                          90
                  ....*....|....*.
gi 568987880  808 EPPEKAIKCKLAYVEP 823
Cdd:cd20415    81 SLPEKARECRLAFIEP 96
Tudor_TDRD4_rpt3 cd20416
third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 968-1049 6.21e-38

third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410487  Cd Length: 82  Bit Score: 136.46  E-value: 6.21e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  968 LEEKMVAAYEHSEWKPVKWECDMHCAVKVPAKNQWRRGQILRMVTDKLVEVLLYDVGVELVVNIHCLRELQENLKTMGRL 1047
Cdd:cd20416     1 LQEKMIAEYENSKPEPVKWENDMHCAVQIQDKKQWRRGQIIRVVSDTLVEVFLYDFGNKEVVNIDCLRKLEENLKTIGKL 80


                  ..
gi 568987880 1048 SL 1049
Cdd:cd20416    81 AL 82
Tudor_TDRD4_rpt1 cd20414
first Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 490-565 4.29e-30

first Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410485  Cd Length: 77  Bit Score: 113.84  E-value: 4.29e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568987880  490 ELGARIFVNSIKNRMWCRGIITEIIPSKTKNIRKPCSPTKFSVCEISLIQIFMVDFGNSEVLIITGVGDTHEGPEH 565
Cdd:cd20414     1 ELGERIAVKSKKNGMWCRGTITELIPLENKNKGKPCGPTRYKIHDVAVMQVFLLDYGHSEVFVVTGVGVLVVRPED 76
TUDOR pfam00567
Tudor domain;
706-819 2.58e-20

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 87.41  E-value: 2.58e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880   706 SVMVCHINSPTDFYLQLMENL-DFLSLLKTIEEFYKgEDGENLEILCPLQNQACVAKfEDGIWYRAKVIGLPGHREVEVK 784
Cdd:pfam00567    4 DVVVSHIESPSTFYIQPKSDSkKLEKLTEELQEYYA-SKPPESLPPAVGDGCVAAFS-EDGKWYRAKITESLDDGLVEVL 81

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 568987880   785 YVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLA 819
Cdd:pfam00567   82 FIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLA 116
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 755-806 1.95e-12

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 63.06  E-value: 1.95e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 568987880    755 NQACVAKFEDGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEF 806
Cdd:smart00333    6 GDKVAARWEDGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLPEEL 57
TUDOR pfam00567
Tudor domain;
943-1053 3.55e-12

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 64.30  E-value: 3.55e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880   943 VNICNVISPEKIYVQWLLTENLLNSLEEKMVAAYEHSEWKPVKWECDMHCAVKVPAKNQWRRGQILRMVTDKLVEVLLYD 1022
Cdd:pfam00567    5 VVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLVEVLFID 84

                           90       100       110
                   ....*....|....*....|....*....|.
gi 568987880  1023 VGVELVVNIHCLRELQENLKTMGRLSLECSL 1053
Cdd:pfam00567   85 YGNTETVPLSDLRPLPPELESLPPQAIKCQL 115
TUDOR pfam00567
Tudor domain;
444-551 9.96e-09

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 54.28  E-value: 9.96e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880   444 VFVSHVIHPCHFYVRKYSQIKDATILEKKMKQVCNRSLHLDPSDILELGArIFVNSIKNrMWCRGIITEIIPSKtknirk 523
Cdd:pfam00567    5 VVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGC-VAAFSEDG-KWYRAKITESLDDG------ 76

                           90       100
                   ....*....|....*....|....*...
gi 568987880   524 pcsptKFSVceisliqiFMVDFGNSEVL 551
Cdd:pfam00567   77 -----LVEV--------LFIDYGNTETV 91
BBC smart00502
B-Box C-terminal domain; Coiled coil region C-terminal to (some) B-Box domains
 158-242 1.69e-04

B-Box C-terminal domain; Coiled coil region C-terminal to (some) B-Box domains


Pssm-ID: 128778  Cd Length: 127  Bit Score: 42.64  E-value: 1.69e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880    158 EQLSNAIKMLDSTQDQTRQETHSLTEAVEKQFDTLLASLDSRKKSLCEELIRRTDDYLSKLVTVKSYIEEKKSDLDAAMK 237
Cdd:smart00502   17 AELEDALKQLISIIQEVEENAADVEAQIKAAFDELRNALNKRKKQLLEDLEEQKENKLKVLEQQLESLTQKQEKLSHAIN 96


                    ....*
gi 568987880    238 IAKEL 242
Cdd:smart00502   97 FTEEA 101
 
Name Accession Description Interval E-value
Tudor_TDRD4_rpt2 cd20415
second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 728-823 2.37e-50

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410486  Cd Length: 96  Bit Score: 172.62  E-value: 2.37e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  728 FLSLLKTIEEFYKGEDGENLEILCPLQNQACVAKFEDGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEFL 807
Cdd:cd20415     1 FLILTKKIQEFYKEGDDGGLEILCPVQGQACVALFEDGAWYRARIIGLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFL 80

                          90
                  ....*....|....*.
gi 568987880  808 EPPEKAIKCKLAYVEP 823
Cdd:cd20415    81 SLPEKARECRLAFIEP 96
Tudor_TDRD4_rpt3 cd20416
third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 968-1049 6.21e-38

third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410487  Cd Length: 82  Bit Score: 136.46  E-value: 6.21e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  968 LEEKMVAAYEHSEWKPVKWECDMHCAVKVPAKNQWRRGQILRMVTDKLVEVLLYDVGVELVVNIHCLRELQENLKTMGRL 1047
Cdd:cd20416     1 LQEKMIAEYENSKPEPVKWENDMHCAVQIQDKKQWRRGQIIRVVSDTLVEVFLYDFGNKEVVNIDCLRKLEENLKTIGKL 80


                  ..
gi 568987880 1048 SL 1049
Cdd:cd20416    81 AL 82
Tudor_TDRD4_rpt1 cd20414
first Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 490-565 4.29e-30

first Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410485  Cd Length: 77  Bit Score: 113.84  E-value: 4.29e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568987880  490 ELGARIFVNSIKNRMWCRGIITEIIPSKTKNIRKPCSPTKFSVCEISLIQIFMVDFGNSEVLIITGVGDTHEGPEH 565
Cdd:cd20414     1 ELGERIAVKSKKNGMWCRGTITELIPLENKNKGKPCGPTRYKIHDVAVMQVFLLDYGHSEVFVVTGVGVLVVRPED 76
TUDOR pfam00567
Tudor domain;
706-819 2.58e-20

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 87.41  E-value: 2.58e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880   706 SVMVCHINSPTDFYLQLMENL-DFLSLLKTIEEFYKgEDGENLEILCPLQNQACVAKfEDGIWYRAKVIGLPGHREVEVK 784
Cdd:pfam00567    4 DVVVSHIESPSTFYIQPKSDSkKLEKLTEELQEYYA-SKPPESLPPAVGDGCVAAFS-EDGKWYRAKITESLDDGLVEVL 81

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 568987880   785 YVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLA 819
Cdd:pfam00567   82 FIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLA 116
Tudor_TDRD15_rpt4 cd20439
fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 705-818 4.17e-19

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410510  Cd Length: 125  Bit Score: 84.46  E-value: 4.17e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  705 VSVMVCHINSPTDFYLQLMENL-DFLSLLKTIEEFYK--GEDGENLEIlcplqnqACVAKF-EDGIWYRAKVIGLPGHRE 780
Cdd:cd20439    12 VDVKCSYVNSPGDFWCQLQTKSsELKSLMKQIQSYYLihNDPYKHGQI-------ACVAKYsKDGKWYRAAVLKQVSAKE 84

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 568987880  781 VEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKL 818
Cdd:cd20439    85 VDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSL 122
Tudor_TDRD15_rpt5 cd20440
fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 703-818 1.29e-16

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410511  Cd Length: 127  Bit Score: 77.11  E-value: 1.29e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  703 TEVSVMVCHINSPTDFYLQLMENLDFLS-LLKTIEEFYKGEDGEnleILCPLQNQACVAK-FEDGIWYRAKVIGLPGHRE 780
Cdd:cd20440    10 SEEEVYITHVYSPAKFYCQLDRNTEILEaLMEKIAEISKLFNSQ---ILDNCKTRLCLAKyFEDGQWYRALAHPVESSSH 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 568987880  781 VEVKYVDFGNTAKITLKDMRKIKDEFLE---PPEKAIKCKL 818
Cdd:cd20440    87 LSVYFVDYGNKQIVEKNEVLPIPDTAVDlllTPMQAIKCCL 127
Tudor_TDRD1_rpt1 cd20408
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 707-830 2.26e-13

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410479  Cd Length: 130  Bit Score: 68.17  E-value: 2.26e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  707 VMVCHINSPTDFYLQLM--ENLDFLSLLKT-IEEFYKGEDGENLEIlcPLQNQACVAKF-EDGIWYRAKVIGL-PGHREV 781
Cdd:cd20408     1 GTVTEFKNPGEFYIQIYtlEVLESLVKLTSqLKKTYASVNNHKEYI--PEVGEVCVAKYsEDQNWYRALVQTVdVQQKKA 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 568987880  782 EVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLAYVEPSKKSqWS 830
Cdd:cd20408    79 GVFYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGS-WS 126
Tudor_TDRD6_rpt3 cd20422
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 707-830 2.31e-13

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410493  Cd Length: 135  Bit Score: 68.31  E-value: 2.31e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  707 VMVCHINSPTDFYLQLMEN-LDFLSLLKTIEEFYKGEDGENLEILCPLQNQACVAKFEDGIWYRAKVIGLPGhREVEVKY 785
Cdd:cd20422     4 AQVEFVKDPSEFWIRLGEHaVPFSKLMRSMTAFYSQASKLDGVVLKPQPGQLCCAKWKEDRYYRAIVTAVKG-KMVEVFL 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 568987880  786 VDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLAYVEPSKKSqWS 830
Cdd:cd20422    83 VDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGER-WS 126
Tudor_dTUD-like cd20379
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ...
 755-802 3.79e-13

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410450  Cd Length: 50  Bit Score: 64.84  E-value: 3.79e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 568987880  755 NQACVAKFE-DGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKI 802
Cdd:cd20379     2 GDLCAAKYEeDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPLSDLRPL 50
Tudor_TDRD6_rpt6 cd20425
sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 705-818 5.41e-13

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410496  Cd Length: 115  Bit Score: 66.33  E-value: 5.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  705 VSVMVCHINSPTDFYLQLMENLDFLSLLKTIEEFYKGEDGENLEILCPLQNQACVAKFEDGIWYRAKVIGLPGHREVEVK 784
Cdd:cd20425     2 TEVYVSHVNSPSDFYVQLAQDEDELSMISEKLNASKANDEEVECESLQLGDLICAEYPEDGLWYRAVVKEKIPNNLVSVQ 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 568987880  785 YVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKL 818
Cdd:cd20425    82 FIDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 755-806 1.95e-12

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 63.06  E-value: 1.95e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 568987880    755 NQACVAKFEDGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEF 806
Cdd:smart00333    6 GDKVAARWEDGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLPEEL 57
TUDOR pfam00567
Tudor domain;
943-1053 3.55e-12

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 64.30  E-value: 3.55e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880   943 VNICNVISPEKIYVQWLLTENLLNSLEEKMVAAYEHSEWKPVKWECDMHCAVKVPAKNQWRRGQILRMVTDKLVEVLLYD 1022
Cdd:pfam00567    5 VVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLVEVLFID 84

                           90       100       110
                   ....*....|....*....|....*....|.
gi 568987880  1023 VGVELVVNIHCLRELQENLKTMGRLSLECSL 1053
Cdd:pfam00567   85 YGNTETVPLSDLRPLPPELESLPPQAIKCQL 115
Tudor_AKAP1 cd20407
Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; ...
 758-823 1.07e-11

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410478  Cd Length: 76  Bit Score: 61.45  E-value: 1.07e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568987880  758 CVAKFEDGiWYRAKVIG-LPGHREVEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLAYVEP 823
Cdd:cd20407    11 CAAPVMNA-WYRAQVVGvFEETDEVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIEP 76
Tudor_TDRD4_rpt5 cd20418
fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 758-823 1.16e-11

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410489  Cd Length: 105  Bit Score: 62.43  E-value: 1.16e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568987880  758 CVAKFEDGIWYRAKVIGLPGHREVE--VKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLAYVEP 823
Cdd:cd20418    10 CLAEYSDGKWYRAKLLSILEFNPVKilVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKP 77
Tudor_TDRD1_rpt4 cd20411
fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 752-819 1.25e-11

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410482  Cd Length: 116  Bit Score: 62.46  E-value: 1.25e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568987880  752 PLQNQACVAKFE-DGIWYRAKVIGLpGHREVEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLA 819
Cdd:cd20411    48 PRIGDACCARFTgDKNWYRAVVLET-SDSEVKVLYADYGNTETLPLSRILPITKSHLELPFQIIRCSLA 115
Tudor_TDRD6_rpt5 cd20424
fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 704-818 1.40e-11

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410495  Cd Length: 126  Bit Score: 62.91  E-value: 1.40e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  704 EVSVMVCHINSPTDFYLQLMENLDFLSLLK-TIEEFYKgedgENLEILCPLQ-NQACVAKFEDGIWYRAKVIGLPghREV 781
Cdd:cd20424    13 EEEVYITYVNDPWTFYCQLARNAGVLDQLAsAISRLSS----EIRKLELSVNpGTLCLAKYSDQHWYRGIIITNK--NST 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 568987880  782 EVKYVDFGNTAKITLKDMRKIKD---EFLEPPEKAIKCKL 818
Cdd:cd20424    87 EVFFVDYGNTEKVEKEDMLPIPSdayELLLLPMQAIKCSL 126
Tudor_TDRD6_rpt4 cd20423
fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 753-818 8.38e-11

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410494  Cd Length: 80  Bit Score: 59.03  E-value: 8.38e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568987880  753 LQNQACVAKF-EDGIWYRAKVIGLPGHRE-VEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKL 818
Cdd:cd20423     4 LPNPVCLAKYsEDGKWCRALIDNVYEPVEmVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSL 71
Tudor_TDRD15_rpt6 cd20441
sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 714-821 1.41e-10

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410512  Cd Length: 108  Bit Score: 59.37  E-value: 1.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  714 SPTDFYLQLMENLDflSLLKTIEEFYKG--EDGENLEILCpLQNQACVAKF-EDGIWYRAKVIGLPGHREVEVKYVDFGN 790
Cdd:cd20441     1 SPSRFFIQLSEDEK--VILQLAEELNETseKSRENAAVKL-KVGDLVAAEYdEDLALYRAVITAVLPGKSFKVEFIDYGN 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 568987880  791 TAKITLKDMRKIKDEFLEPPEKAIKCKLAYV 821
Cdd:cd20441    78 TAVVDKSNIYTLQEKFLSLPRLSIPCSLSGV 108
Tudor_AtTudor1-like cd20443
Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor ...
 718-823 5.75e-10

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410514 [Multi-domain]  Cd Length: 117  Bit Score: 57.86  E-value: 5.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  718 FYLQLMENLDFLSLLKTIEEfYKGEDGENLE-ILCPLQNQACVAKFE-DGIWYRAKVIGLP------GHREVEVKYVDFG 789
Cdd:cd20443     4 FYVQVVSDQRLSSIQQQLEG-LSLKDKANPPgGFNPKKGELVLAQFSaDNSWNRAMVVNAPrqgtqsPKDEYEVFYIDYG 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 568987880  790 NTAKITLKDMRKIKDEFLEPPEKAIKCKLAYVEP 823
Cdd:cd20443    83 NQETVPLSALRPLDPSVSSAPGLAQLCSLAHIKV 116
Tudor_TDRD15_rpt2 cd20437
second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 703-819 1.04e-09

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410508  Cd Length: 120  Bit Score: 57.43  E-value: 1.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  703 TEVSVMVCHINSPTDFYLQLME-NLDFLSLLKTIEEFYKGEDGENLEilcPLQN--QACVAKFEDGIWYRAKVIGLPGHR 779
Cdd:cd20437     3 TTEKVKITAAVSPSKFYCQLLSwEPELSKLTTQMTLHYESVSKELNP---SCENfgLLCAAKGKDGQWHRGFLQQLLPPS 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 568987880  780 EVEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLA 819
Cdd:cd20437    80 QVKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSLS 119
Tudor_TDRD15_rpt3 cd20438
third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 709-823 1.11e-09

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410509  Cd Length: 141  Bit Score: 57.87  E-value: 1.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  709 VCHINSPTDFYLQLME-NLDFLSLLKTIEEFYKGEDGENLEILCPLQNQACVAKF-EDGIWYRAKVIGLPGHrEVEVKYV 786
Cdd:cd20438    11 VEYVLNPSNFWIRTDEyNNEFQALMKNIADIYNLCGNDEELLKKPEPGLLCCARYsKDRHYYRAVITEVLDL-KVSVYFL 89

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 568987880  787 DFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLAYVEP 823
Cdd:cd20438    90 DFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAHVFP 126
Tudor_TDRD11 cd20433
Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, ...
 758-806 1.38e-09

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410504 [Multi-domain]  Cd Length: 84  Bit Score: 55.77  E-value: 1.38e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 568987880  758 CVAKF-EDGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEF 806
Cdd:cd20433    34 CAAKFvEDGEWYRAKVEKVEGDKKVHVLYIDYGNREVLPSTRLAALPPAF 83
Tudor_TDRD6_rpt7 cd20426
seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 712-830 1.53e-09

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410497  Cd Length: 140  Bit Score: 57.51  E-value: 1.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  712 INSPTDFYLQL-MENLDFLSllKTIEEFYKGEDGENLEILCPLQNQACVAKF-EDGIWYRAKVIGLPGHReVEVKYVDFG 789
Cdd:cd20426     8 VDSPEYFWCQFaTEKIQCLA--VKVQEAGEQVADRGNFIPSIYVGDPCIVKYsEDNHWYRALVTKINDNL-VSVRFVDYG 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 568987880  790 NTAKITLKDMRKIKDEFLEPPEKAIKCKLAYVEPSKKSqWS 830
Cdd:cd20426    85 NEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGL-WS 124
Tudor_TDRD6_rpt2 cd20421
second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 693-818 3.79e-09

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410492  Cd Length: 130  Bit Score: 55.89  E-value: 3.79e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  693 YHPPILPEEMTEvSVMVCHINSPTDFYLQLM---ENLDFLSLlkTIEEFYKGEDGENLEILCPLQNQACVAKFEDGIWYR 769
Cdd:cd20421     2 YFYPQLQVGVTE-TVVVTEVTDPHRIFCQLRslsQELKRLSE--SMHQYYEGRVGSGYETRPEKLGSPCAARGSDGRWYR 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 568987880  770 AKVIG-LPGHREVEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKL 818
Cdd:cd20421    79 AVLQQvFSANRVVEVLHVDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCAL 128
Tudor_TDRD2 cd20412
Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, ...
 726-816 5.76e-09

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410483  Cd Length: 95  Bit Score: 54.22  E-value: 5.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  726 LDflSLLKTIEEFYkgEDGENLEILCPLQ-NQACVAKFE-DGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIK 803
Cdd:cd20412     6 LD--KLVQEMTQYY--ESEENRHTLLTVQvGDIVAAPFRhDGSWYRARVLGFLENGNLDLYFVDYGDSGYVPLEDLRALR 81

                          90
                  ....*....|...
gi 568987880  804 DEFLEPPEKAIKC 816
Cdd:cd20412    82 SDFLSLPFQAIEC 94
Tudor_dTUD-like cd20379
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ...
 989-1037 8.03e-09

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410450  Cd Length: 50  Bit Score: 52.52  E-value: 8.03e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 568987880  989 DMHCAVKVPAKNQWRRGQILRMVTDKLVEVLLYDVGVELVVNIHCLREL 1037
Cdd:cd20379     2 GDLCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPLSDLRPL 50
TUDOR pfam00567
Tudor domain;
444-551 9.96e-09

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 54.28  E-value: 9.96e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880   444 VFVSHVIHPCHFYVRKYSQIKDATILEKKMKQVCNRSLHLDPSDILELGArIFVNSIKNrMWCRGIITEIIPSKtknirk 523
Cdd:pfam00567    5 VVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGC-VAAFSEDG-KWYRAKITESLDDG------ 76

                           90       100
                   ....*....|....*....|....*...
gi 568987880   524 pcsptKFSVceisliqiFMVDFGNSEVL 551
Cdd:pfam00567   77 -----LVEV--------LFIDYGNTETV 91
Tudor_TDRD9 cd20431
Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is ...
 743-810 1.16e-08

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410502  Cd Length: 101  Bit Score: 53.55  E-value: 1.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  743 DGENLEILCPL-----QNQ------------ACVAKFEDGI---WYRAKVIGLPGHrEVEVKYVDFGNTAKITLKDMRKI 802
Cdd:cd20431    15 DENSSEILQQLtaeinQRQlvplttkpvpnlLCLAPFTDADmkkYYRAKILYVSGS-SAEVFFVDYGNTSQVPSSLLREI 93


                  ....*...
gi 568987880  803 KDEFLEPP 810
Cdd:cd20431    94 PETLLTLP 101
Tudor_TDRD1_rpt2 cd20409
second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 751-807 1.61e-08

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410480  Cd Length: 82  Bit Score: 52.84  E-value: 1.61e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568987880  751 CPLQNQACVAKF-EDGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEFL 807
Cdd:cd20409    25 SPAVGEVCCAQFtEDNQWYRASVLAYSSEDSVLVGYIDFGNSEEVALSRLRPIPPSLL 82
Tudor_TDRD5 cd20419
Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is ...
 709-818 1.87e-08

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410490  Cd Length: 118  Bit Score: 53.61  E-value: 1.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  709 VCHINSPTDFYLQLMENLD---FLSLLKTIEEFYKGEDGENLEIL---CPLQNQACVAKF-EDGIWYRAKVIGLPGHREV 781
Cdd:cd20419     2 VEYIESPSQFYVRFYSKDTsemLEDMMIEMRRCYSNEHVSERYVMpeaFIQPGQVCCVRIpEDVWWYRVIIHQVLNKQEV 81

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 568987880  782 EVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKL 818
Cdd:cd20419    82 EVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118
Tudor_TDRD1_rpt3 cd20410
third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 752-807 2.67e-08

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410481 [Multi-domain]  Cd Length: 59  Bit Score: 51.19  E-value: 2.67e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568987880  752 PLQNQACVAKF-EDGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEFL 807
Cdd:cd20410     3 PIVGEPCCAFFsGDGNWYRAMVKEILPGGAVKVHFVDYGNVEEVTLDKLRKITSTFL 59
Tudor_TDRD7_rpt1 cd20427
first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
 735-823 1.88e-07

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410498  Cd Length: 98  Bit Score: 50.12  E-value: 1.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  735 IEEFYKgEDGENLEILCPLQNQACVAKFEDGIWYRAKVIGLPGHReVEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAI 814
Cdd:cd20427     7 MKEFYS-KSSTAMCLRSPSVGQLVAVKAEEDAWLRAQVIEVEEDK-VKVYYVDHGFSEVVERSKLFKLNKQFYSLPFQAT 84


                  ....*....
gi 568987880  815 KCKLAYVEP 823
Cdd:cd20427    85 KCKLAGLEP 93
Tudor_vreteno-like_rpt2 cd20445
second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; ...
 755-810 3.73e-07

second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410516  Cd Length: 56  Bit Score: 47.80  E-value: 3.73e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568987880  755 NQACVAKFEDGiWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEFLEPP 810
Cdd:cd20445     2 NELCIAKYMDK-WYRAVCLESVGDGRPTVLFCDYGNILMARLTDIRPFPPTFATEP 56
Tudor_TDRD15_rpt2 cd20437
second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 943-1053 6.12e-07

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410508  Cd Length: 120  Bit Score: 49.34  E-value: 6.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  943 VNICNVISPEKIYVQWLLTENLLNSLEEKMVAAYE--HSEWKPVKWECDMHCAVKvPAKNQWRRGQILRMVTDKLVEVLL 1020
Cdd:cd20437     7 VKITAAVSPSKFYCQLLSWEPELSKLTTQMTLHYEsvSKELNPSCENFGLLCAAK-GKDGQWHRGFLQQLLPPSQVKVWF 85

                          90       100       110
                  ....*....|....*....|....*....|...
gi 568987880 1021 YDVGVELVVNIHCLRELQENLKTMGRLSLECSL 1053
Cdd:cd20437    86 IDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSL 118
Tudor_TDRD7_rpt2 cd20428
second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
 707-819 3.82e-06

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410499  Cd Length: 140  Bit Score: 47.44  E-value: 3.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  707 VMVCHINSPTDFYLQL-MENLDFLS-LLKTIEEFYKGED-GENLEILCPLQNQACVAKFEdGIWYRAKVIGLPGHREVEV 783
Cdd:cd20428     4 VRVTNVCSDGTLYCQVpSKGLSKLNeILDKIEYYFHSRQmTSEYFVSLPFCGKICLARYK-GKWARVEITNVHSSRALDV 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 568987880  784 KYVDFGNTAKITLKDMRKIKDEFLEP----PEKAIKCKLA 819
Cdd:cd20428    83 HFLDTGTVASVKVSELREIPPPFLRElisiPPQALKCCLA 122
Tudor_TDRD6_rpt3 cd20422
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 987-1072 4.50e-05

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410493  Cd Length: 135  Bit Score: 44.42  E-value: 4.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  987 ECDMHCAVKVpAKNQWRRGQILRmVTDKLVEVLLYDVGVELVVNIHCLRELQENLKTMGRLSLECSLVDIRPTGgsDKWT 1066
Cdd:cd20422    51 QPGQLCCAKW-KEDRYYRAIVTA-VKGKMVEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLG--ERWS 126


                  ....*.
gi 568987880 1067 ATACDC 1072
Cdd:cd20422   127 PEAISA 132
Tudor_ZGPAT cd20384
Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and ...
 758-798 5.43e-05

Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and similar proteins; ZGPAT, also called ZIP, G patch domain-containing protein 6 (GPATC6), GPATCH6, zinc finger CCCH domain-containing protein 9 (ZC3HDC9), ZC3H9, or zinc finger and G patch domain-containing protein, is a transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. It represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410455  Cd Length: 55  Bit Score: 41.83  E-value: 5.43e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 568987880  758 CVAKFEDGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKD 798
Cdd:cd20384    11 CLAKYDDGLWYPATVTDIDEDGKYTVKFDSYGEVAVVELDD 51
Tudor_TDRD12_rpt2 cd20435
second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; ...
 714-814 6.60e-05

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410506  Cd Length: 134  Bit Score: 43.78  E-value: 6.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  714 SPTDFYLQLME------------NLDFLSLLKTIEEFYKgeDGENLEILCPLQ-NQACVAKFEDGIWYRAKVIGLP---- 776
Cdd:cd20435     1 DATHYSARILEhrssdgevtksmSSTYLKLSMKLNMYYS--DPSNRILHGKVKvGDLCAVEDENNLYHRVKVLEITekdd 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 568987880  777 --GHREVEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAI 814
Cdd:cd20435    79 ktKPREVLVKFIDEGRVETVVVSQLLELPEELKSLPPQAV 118
Tudor_TDRD15_rpt1 cd20436
first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 945-1074 8.55e-05

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410507  Cd Length: 147  Bit Score: 43.95  E-value: 8.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  945 ICNVISPEKIYVQWlltENLLNSLEEKMVAAYE----HSEWKPVKWECDMHCAVKVPAKNQWRRGQILRmVTDKLVEVLL 1020
Cdd:cd20436     5 THRVCHPKEVLVKF---QGQYNSICELDYHILQneiqNATKSKSSWGVGEFCLVEDTTSGEWYRGRVLE-KIDEKYEVFL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568987880 1021 YDVGVELVVNIHCLRELQENLKTMGRLSLECSLVDIRPTGGsdKWTATACDCLS 1074
Cdd:cd20436    81 IDRGEVLNVHATNMASASGELFQLPPKAVCGIFANILPIGE--KWSSTAVNYFS 132
Tudor_TDRD6_rpt6 cd20425
sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 943-1053 1.51e-04

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410496  Cd Length: 115  Bit Score: 42.44  E-value: 1.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  943 VNICNVISPEKIYVQWLLTENLLNSLEEKMVAAYEHSEW--KPVKWECDMHCAVkVPAKNQWRRGQILRMVTDKLVEVLL 1020
Cdd:cd20425     4 VYVSHVNSPSDFYVQLAQDEDELSMISEKLNASKANDEEveCESLQLGDLICAE-YPEDGLWYRAVVKEKIPNNLVSVQF 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 568987880 1021 YDVGVELVVNIHCLRELQENLKTMGRLSLECSL 1053
Cdd:cd20425    83 IDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115
Tudor_TDRD8 cd20430
Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, ...
 760-806 1.68e-04

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410501 [Multi-domain]  Cd Length: 75  Bit Score: 41.12  E-value: 1.68e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 568987880  760 AKF-EDGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEF 806
Cdd:cd20430    27 GKFsEDNCWYRCKVKSILSDEKCTVQYIDYGNTETVSRSSIVELPPDL 74
BBC smart00502
B-Box C-terminal domain; Coiled coil region C-terminal to (some) B-Box domains
 158-242 1.69e-04

B-Box C-terminal domain; Coiled coil region C-terminal to (some) B-Box domains


Pssm-ID: 128778  Cd Length: 127  Bit Score: 42.64  E-value: 1.69e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880    158 EQLSNAIKMLDSTQDQTRQETHSLTEAVEKQFDTLLASLDSRKKSLCEELIRRTDDYLSKLVTVKSYIEEKKSDLDAAMK 237
Cdd:smart00502   17 AELEDALKQLISIIQEVEENAADVEAQIKAAFDELRNALNKRKKQLLEDLEEQKENKLKVLEQQLESLTQKQEKLSHAIN 96


                    ....*
gi 568987880    238 IAKEL 242
Cdd:smart00502   97 FTEEA 101
Tudor_TDRD1_rpt1 cd20408
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 950-1070 1.78e-04

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410479  Cd Length: 130  Bit Score: 42.74  E-value: 1.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  950 SPEKIYVQWLLTENL--LNSLEEKMVAAY----EHSEWKPVKWECdmhCAVKVPAKNQWRRGQIL-RMVTDKLVEVLLYD 1022
Cdd:cd20408     8 NPGEFYIQIYTLEVLesLVKLTSQLKKTYasvnNHKEYIPEVGEV---CVAKYSEDQNWYRALVQtVDVQQKKAGVFYID 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 568987880 1023 VGVELVVNIHCLRELQENLKTMGRLSLECSLVDIRPTGGSdkWTATAC 1070
Cdd:cd20408    85 YGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGS--WSEECI 130
Tudor_TDRD15_rpt7 cd20442
seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 758-827 2.46e-04

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410513  Cd Length: 160  Bit Score: 42.72  E-value: 2.46e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568987880  758 CVAKFEDGI-WYRAKVIGL-PGHREVEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLAYVEPSKKS 827
Cdd:cd20442    56 CLAKSKKNLkWYRAVVEHLyPETEKMLVFFVDHGITEVVSMGNIKQLSNDLLQIPRQAVLCRWNWPESSKEL 127
Tudor_TDRD7_rpt3 cd20429
third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
 965-1039 2.95e-04

third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410500  Cd Length: 91  Bit Score: 40.93  E-value: 2.95e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568987880  965 LNSLEEKMVAAYEHSEWKPVKWECDMHCAVKVpaKNQWRRGQILRMVTDKLVEVLLYDVGVELVVNIHCLRELQE 1039
Cdd:cd20429     9 LEVLMEEMILYYNKTEERPVAIEKNKVYAAKI--ENNWYRVLVKGILTNGLVSVYELDYGKHELVSIRKVQPLIE 81
Tudor_SF cd04508
Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally ...
 755-800 7.99e-04

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.


Pssm-ID: 410449 [Multi-domain]  Cd Length: 47  Bit Score: 38.34  E-value: 7.99e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 568987880  755 NQACVAKF-EDGIWYRAKVIGLPGHREVEVKYVDfGNTAKITLKDMR 800
Cdd:cd04508     1 GDRVEAKWsDDGQWYPATVVAVNDDGKYTVLFDD-GNEEEVSEDDIR 46
Tudor_TDRD15_rpt7 cd20442
seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 943-1051 8.33e-04

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410513  Cd Length: 160  Bit Score: 41.18  E-value: 8.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  943 VNICNVISPEKIYVQWLLTENLLNSLEEKMV-AAYEHSEWKPVKWECDMHCAVKVPAKNQWRRGQILRMVTDKL-VEVLL 1020
Cdd:cd20442     6 GTLLSVSKNGTFYVRLLRNSEQLTDLESLIAkEAKKCKFVPVEDIKEGLECLAKSKKNLKWYRAVVEHLYPETEkMLVFF 85

                          90       100       110
                  ....*....|....*....|....*....|.
gi 568987880 1021 YDVGVELVVNIHCLRELQENLKTMGRLSLEC 1051
Cdd:cd20442    86 VDHGITEVVSMGNIKQLSNDLLQIPRQAVLC 116
Tudor_TDRD5 cd20419
Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is ...
 947-1053 1.14e-03

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410490  Cd Length: 118  Bit Score: 40.12  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  947 NVISPEKIYVQWL--LTENLLNSLEEKMVAAYE---HSEWKPVKwECDMH----CAVKVPAKNQWRRGQILRMVTDKLVE 1017
Cdd:cd20419     4 YIESPSQFYVRFYskDTSEMLEDMMIEMRRCYSnehVSERYVMP-EAFIQpgqvCCVRIPEDVWWYRVIIHQVLNKQEVE 82

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 568987880 1018 VLLYDVGVELVVNIHCLRELQENLKTMGRLSLECSL 1053
Cdd:cd20419    83 VFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118
Tudor_vreteno-like_rpt1 cd20444
first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; ...
 752-806 1.49e-03

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410515  Cd Length: 55  Bit Score: 37.67  E-value: 1.49e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568987880  752 PLQNQACVAKFeDGIWYRAKVIGlPGHREVE--VKYVDFGNTAKITLKDMRKIKDEF 806
Cdd:cd20444     1 PTPGQMVIAKF-DGNHYRAIVLR-VLNPDLKilVRFVDFGNVEVMKLENLYECPEYL 55
Tudor_TDRD4_rpt4 cd20417
fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 756-794 2.67e-03

fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410488  Cd Length: 68  Bit Score: 37.41  E-value: 2.67e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 568987880  756 QACVAKFEDGIWYRAKVIGLPGHrEVEVKYVDFGNTAKI 794
Cdd:cd20417     5 EGCVVRGSDTLWYRGKVLEVIGG-MVRVQYVDQGYIEKI 42
Tudor_TDRD15_rpt1 cd20436
first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 765-830 5.07e-03

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410507  Cd Length: 147  Bit Score: 38.56  E-value: 5.07e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987880  765 GIWYRAKVIglpghREVEVKY----VDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLAYVEPSkKSQWS 830
Cdd:cd20436    61 GEWYRGRVL-----EKIDEKYevflIDRGEVLNVHATNMASASGELFQLPPKAVCGIFANILPI-GEKWS 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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