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Conserved domains on  [gi|568993097|ref|XP_006521347|]
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fidgetin-like protein 2 isoform X1 [Mus musculus]

Protein Classification

P-loop NTPase family protein( domain architecture ID 1562424)

P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 388-546 1.15e-68

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member cd19523:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 163  Bit Score: 220.91  E-value: 1.15e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 388 DVAGQGALKAALEEELLWPLLRPPACPGSALPPRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARL 467
Cdd:cd19523    1 DIAGLGALKAAIKEEVLWPLLRPDAFSGLLRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEKI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 468 LQAAFAAARCRPPAVLLISELDALLPARDDGAS----LRAPLLTCLDGSCGARADGVLVVGTTSRPAALDEATRRRFALR 543
Cdd:cd19523   81 LQASFLAARCRQPSVLFISDLDALLSSQDDEASpvgrLQVELLAQLDGVLGSGEDGVLVVCTTSKPEEIDESLRRYFSKR 160


                 ...
gi 568993097 544 FYV 546
Cdd:cd19523  161 LLV 163
 
Name Accession Description Interval E-value
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 388-546 1.15e-68

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 220.91  E-value: 1.15e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 388 DVAGQGALKAALEEELLWPLLRPPACPGSALPPRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARL 467
Cdd:cd19523    1 DIAGLGALKAAIKEEVLWPLLRPDAFSGLLRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEKI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 468 LQAAFAAARCRPPAVLLISELDALLPARDDGAS----LRAPLLTCLDGSCGARADGVLVVGTTSRPAALDEATRRRFALR 543
Cdd:cd19523   81 LQASFLAARCRQPSVLFISDLDALLSSQDDEASpvgrLQVELLAQLDGVLGSGEDGVLVVCTTSKPEEIDESLRRYFSKR 160


                 ...
gi 568993097 544 FYV 546
Cdd:cd19523  161 LLV 163
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 419-621 9.54e-41

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 153.14  E-value: 9.54e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 419 PPRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARLLQAAFAAARCRPPAVLLISELDALLPARDDG 498
Cdd:COG0464  190 PPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGETEKNLREVFDKARGLAPCVLFIDEADALAGKRGEV 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 499 ASLRAP-----LLTCLDGscgaRADGVLVVGTTSRPAALDEATRRRFALRFYVALPDGAARGQILQRALAQQGCALNErE 573
Cdd:COG0464  270 GDGVGRrvvntLLTEMEE----LRSDVVVIAATNRPDLLDPALLRRFDEIIFFPLPDAEERLEIFRIHLRKRPLDEDV-D 344

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 568993097 574 LAALVQGTQGFSGGELGQLCQQAAAEAgISGLQRPLSYKDVEAALAKV 621
Cdd:COG0464  345 LEELAEATEGLSGADIRNVVRRAALQA-LRLGREPVTTEDLLEALERE 391
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 423-546 5.17e-26

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 103.44  E-value: 5.17e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097  423 VLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARLLQAAFAAARCRPPAVLLISELDALLPARDDGASLR 502
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 568993097  503 AP-----LLTCLDGScGARADGVLVVGTTSRPAALDEATRRRFALRFYV 546
Cdd:pfam00004  81 SRrvvnqLLTELDGF-TSSNSKVIVIAATNRPDKLDPALLGRFDRIIEF 128
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 360-600 1.25e-23

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 106.14  E-value: 1.25e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097  360 EPAKGVDPGALELVSSKMvdcgPPVQWADVAGQGALKAALEEELLWPLLRPPACPGSAL-PPRTVLFFGPRGCGKALLGR 438
Cdd:TIGR01243 430 EALKMVEPSAIREVLVEV----PNVRWSDIGGLEEVKQELREAVEWPLKHPEIFEKMGIrPPKGVLLFGPPGTGKTLLAK 505

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097  439 CLATRLGATLLRLRGAGLAASGAVEGARLLQAAFAAARCRPPAVLLISELDALLPARddGASLRAP--------LLTCLD 510
Cdd:TIGR01243 506 AVATESGANFIAVRGPEILSKWVGESEKAIREIFRKARQAAPAIIFFDEIDAIAPAR--GARFDTSvtdrivnqLLTEMD 583

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097  511 GScgARADGVLVVGTTSRPAALDEATRR--RFALRFYVALPDGAARGQILQRALAQQGCAlNERELAALVQGTQGFSGGE 588
Cdd:TIGR01243 584 GI--QELSNVVVIAATNRPDILDPALLRpgRFDRLILVPPPDEEARKEIFKIHTRSMPLA-EDVDLEELAEMTEGYTGAD 660

                         250
                  ....*....|..
gi 568993097  589 LGQLCQQAAAEA 600
Cdd:TIGR01243 661 IEAVCREAAMAA 672
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 419-641 4.55e-21

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 95.67  E-value: 4.55e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 419 PPRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARLLQAAFAAARCRPPAVLLISELDALLPAR-DD 497
Cdd:PRK03992 164 PPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFIGEGARLVRELFELAREKAPSIIFIDEIDAIAAKRtDS 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 498 GASLRAP-------LLTCLDGsCGARADgVLVVGTTSRPAALDEATRR--RFALRFYVALPDGAARGQILQraLAQQGCA 568
Cdd:PRK03992 244 GTSGDREvqrtlmqLLAEMDG-FDPRGN-VKIIAATNRIDILDPAILRpgRFDRIIEVPLPDEEGRLEILK--IHTRKMN 319

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 569 LNE----RELAALvqgTQGFSGGELGQLCqqaaAEAGISGLQRPLSY---KDVEAALAKVGSrapSKELDSLVEWDKMYG 641
Cdd:PRK03992 320 LADdvdlEELAEL---TEGASGADLKAIC----TEAGMFAIRDDRTEvtmEDFLKAIEKVMG---KEEKDSMEEPGVMFA 389
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 419-550 4.44e-09

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 55.46  E-value: 4.44e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097   419 PPRTVLFFGPRGCGKALLGRCLATRLGAT-----------------LLRLRGAGLAASGAVEGARLLQAAFAAARCRPPA 481
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPgggviyidgedileevlDQLLLIIVGGKKASGSGELRLRLALALARKLKPD 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097   482 VLLISELDALLPARDDGASLRAPLLTCLDGScgARADGVLVVGTTSRPAALDEA-TRRRFALRFYVALPD 550
Cdd:smart00382  81 VLILDEITSLLDAEQEALLLLLEELRLLLLL--KSEKNLTVILTTNDEKDLGPAlLRRRFDRRIVLLLIL 148
 
Name Accession Description Interval E-value
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 388-546 1.15e-68

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 220.91  E-value: 1.15e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 388 DVAGQGALKAALEEELLWPLLRPPACPGSALPPRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARL 467
Cdd:cd19523    1 DIAGLGALKAAIKEEVLWPLLRPDAFSGLLRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEKI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 468 LQAAFAAARCRPPAVLLISELDALLPARDDGAS----LRAPLLTCLDGSCGARADGVLVVGTTSRPAALDEATRRRFALR 543
Cdd:cd19523   81 LQASFLAARCRQPSVLFISDLDALLSSQDDEASpvgrLQVELLAQLDGVLGSGEDGVLVVCTTSKPEEIDESLRRYFSKR 160


                 ...
gi 568993097 544 FYV 546
Cdd:cd19523  161 LLV 163
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 366-546 5.13e-45

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 158.61  E-value: 5.13e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 366 DPGALELVSSKMVDCGPPVQWADVAGQGALKAALEEELLWPLLRPPACPGSALPPRTVLFFGPRGCGKALLGRCLATRLG 445
Cdd:cd19525    1 EPKMIELIMSEIMDHGPPINWADIAGLEFAKKTIKEIVVWPMLRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 446 ATLLRLRGAGLAASGAVEGARLLQAAFAAARCRPPAVLLISELDALLPARDDGA-----SLRAPLLTCLDGSCGARADGV 520
Cdd:cd19525   81 ATFFSISASSLTSKWVGEGEKMVRALFSVARCKQPAVIFIDEIDSLLSQRGEGEhessrRIKTEFLVQLDGATTSSEDRI 160

                        170       180
                 ....*....|....*....|....*.
gi 568993097 521 LVVGTTSRPAALDEATRRRFALRFYV 546
Cdd:cd19525  161 LVVGATNRPQEIDEAARRRLVKRLYI 186
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 419-621 9.54e-41

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 153.14  E-value: 9.54e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 419 PPRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARLLQAAFAAARCRPPAVLLISELDALLPARDDG 498
Cdd:COG0464  190 PPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGETEKNLREVFDKARGLAPCVLFIDEADALAGKRGEV 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 499 ASLRAP-----LLTCLDGscgaRADGVLVVGTTSRPAALDEATRRRFALRFYVALPDGAARGQILQRALAQQGCALNErE 573
Cdd:COG0464  270 GDGVGRrvvntLLTEMEE----LRSDVVVIAATNRPDLLDPALLRRFDEIIFFPLPDAEERLEIFRIHLRKRPLDEDV-D 344

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 568993097 574 LAALVQGTQGFSGGELGQLCQQAAAEAgISGLQRPLSYKDVEAALAKV 621
Cdd:COG0464  345 LEELAEATEGLSGADIRNVVRRAALQA-LRLGREPVTTEDLLEALERE 391
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 419-624 1.21e-38

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 145.53  E-value: 1.21e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 419 PPRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARLLQAAFAAARCRPPAVLLISELDALLPARDDG 498
Cdd:COG1222  111 PPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYIGEGARNVREVFELAREKAPSIIFIDEIDAIAARRTDD 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 499 ASLR------APLLTCLDGsCGARaDGVLVVGTTSRPAALDEATRR--RFALRFYVALPDGAARGQILQRALAQQGCAlN 570
Cdd:COG1222  191 GTSGevqrtvNQLLAELDG-FESR-GDVLIIAATNRPDLLDPALLRpgRFDRVIEVPLPDEEAREEILKIHLRDMPLA-D 267

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568993097 571 ERELAALVQGTQGFSGGELGQLCQQAAAEAGISGLQRpLSYKDVEAALAKVGSR 624
Cdd:COG1222  268 DVDLDKLAKLTEGFSGADLKAIVTEAGMFAIREGRDT-VTMEDLEKAIEKVKKK 320
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 389-546 1.61e-36

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 134.40  E-value: 1.61e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 389 VAGQGALKAALEEELLWPLLRPPACPGSALPPRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARLL 468
Cdd:cd19509    1 IAGLDDAKEALKEAVILPSLRPDLFPGLRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEKIV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 469 QAAFAAARCRPPAVLLISELDALLPARDDG-----ASLRAPLLTCLDGSCGARADGVLVVGTTSRPAALDEATRRRFALR 543
Cdd:cd19509   81 RALFALARELQPSIIFIDEIDSLLSERGSGeheasRRVKTEFLVQMDGVLNKPEDRVLVLGATNRPWELDEAFLRRFEKR 160


                 ...
gi 568993097 544 FYV 546
Cdd:cd19509  161 IYI 163
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
419-620 1.32e-31

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 123.07  E-value: 1.32e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 419 PPRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARLLQAAFAAARCRPpAVLLISELDALLPARDDg 498
Cdd:COG1223   34 PPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYLGETARNLRKLFDFARRAP-CVIFFDEFDAIAKDRGD- 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 499 ASLRA-------PLLTCLDGscgaRADGVLVVGTTSRPAALDEATRRRFALRFYVALPDGAARGQILQRALaqQGCALN- 570
Cdd:COG1223  112 QNDVGevkrvvnALLQELDG----LPSGSVVIAATNHPELLDSALWRRFDEVIEFPLPDKEERKEILELNL--KKFPLPf 185

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 568993097 571 ERELAALVQGTQGFSGGELGQLCQQAAAEAGISGLQRpLSYKDVEAALAK 620
Cdd:COG1223  186 ELDLKKLAKKLEGLSGADIEKVLKTALKKAILEDREK-VTKEDLEEALKQ 234
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 419-544 2.33e-29

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 113.92  E-value: 2.33e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 419 PPRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARLLQAAFAAARCRPPAVLLISELDALLPARDDG 498
Cdd:cd19481   25 LPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIFERARRLAPCILFIDEIDAIGRKRDSS 104

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568993097 499 ASLRAP------LLTCLDGscGARADGVLVVGTTSRPAALDEATRRRfaLRF 544
Cdd:cd19481  105 GESGELrrvlnqLLTELDG--VNSRSKVLVIAATNRPDLLDPALLRP--GRF 152
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 388-546 2.17e-26

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 105.70  E-value: 2.17e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 388 DVAGQGALKAALEEELLWPLLRPPACPGSALPPRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARL 467
Cdd:cd19524    1 DIAGQDLAKQALQEMVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 468 LQAAFAAARCRPPAVLLISELDALLPARDDGAS-----LRAPLLTCLDGSCGARADGVLVVGTTSRPAALDEATRRRFAL 542
Cdd:cd19524   81 VRALFAVARELQPSIIFIDEVDSLLSERSEGEHeasrrLKTEFLIEFDGVQSNGDDRVLVMGATNRPQELDDAVLRRFTK 160


                 ....
gi 568993097 543 RFYV 546
Cdd:cd19524  161 RVYV 164
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 423-546 5.17e-26

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 103.44  E-value: 5.17e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097  423 VLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARLLQAAFAAARCRPPAVLLISELDALLPARDDGASLR 502
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 568993097  503 AP-----LLTCLDGScGARADGVLVVGTTSRPAALDEATRRRFALRFYV 546
Cdd:pfam00004  81 SRrvvnqLLTELDGF-TSSNSKVIVIAATNRPDKLDPALLGRFDRIIEF 128
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 382-546 5.48e-25

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 101.86  E-value: 5.48e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 382 PPVQWADVAGQGALKAALEEELLWPLLRPPACPGSALPPRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGA 461
Cdd:cd19521    2 PNVKWEDVAGLEGAKEALKEAVILPVKFPHLFTGNRKPWSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWM 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 462 VEGARLLQAAFAAARCRPPAVLLISELDALLPARDDGAS-----LRAPLLTCLDGsCGARADGVLVVGTTSRPAALDEAT 536
Cdd:cd19521   82 GESEKLVKQLFAMARENKPSIIFIDEVDSLCGTRGEGESeasrrIKTELLVQMNG-VGNDSQGVLVLGATNIPWQLDSAI 160

                        170
                 ....*....|
gi 568993097 537 RRRFALRFYV 546
Cdd:cd19521  161 RRRFEKRIYI 170
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 419-540 6.98e-25

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 101.21  E-value: 6.98e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 419 PPRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARLLQAAFAAARCRPPAVLLISELDALLPARDDG 498
Cdd:cd19503   33 PPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESEKNLREIFEEARSHAPSIIFIDEIDALAPKREED 112

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 568993097 499 -----ASLRAPLLTCLDGScgARADGVLVVGTTSRPAALDEATRR--RF 540
Cdd:cd19503  113 qreveRRVVAQLLTLMDGM--SSRGKVVVIAATNRPDAIDPALRRpgRF 159
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 360-600 1.25e-23

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 106.14  E-value: 1.25e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097  360 EPAKGVDPGALELVSSKMvdcgPPVQWADVAGQGALKAALEEELLWPLLRPPACPGSAL-PPRTVLFFGPRGCGKALLGR 438
Cdd:TIGR01243 430 EALKMVEPSAIREVLVEV----PNVRWSDIGGLEEVKQELREAVEWPLKHPEIFEKMGIrPPKGVLLFGPPGTGKTLLAK 505

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097  439 CLATRLGATLLRLRGAGLAASGAVEGARLLQAAFAAARCRPPAVLLISELDALLPARddGASLRAP--------LLTCLD 510
Cdd:TIGR01243 506 AVATESGANFIAVRGPEILSKWVGESEKAIREIFRKARQAAPAIIFFDEIDAIAPAR--GARFDTSvtdrivnqLLTEMD 583

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097  511 GScgARADGVLVVGTTSRPAALDEATRR--RFALRFYVALPDGAARGQILQRALAQQGCAlNERELAALVQGTQGFSGGE 588
Cdd:TIGR01243 584 GI--QELSNVVVIAATNRPDILDPALLRpgRFDRLILVPPPDEEARKEIFKIHTRSMPLA-EDVDLEELAEMTEGYTGAD 660

                         250
                  ....*....|..
gi 568993097  589 LGQLCQQAAAEA 600
Cdd:TIGR01243 661 IEAVCREAAMAA 672
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 419-600 1.06e-22

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 103.06  E-value: 1.06e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097  419 PPRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARLLQAAFAAARCRPPAVLLISELDALLPARDDG 498
Cdd:TIGR01243 211 PPKGVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEIMSKYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEV 290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097  499 AS-----LRAPLLTCLDGSCGaRADgVLVVGTTSRPAALDEATRR--RFALRFYVALPDGAARGQILQRALAQQGCAlNE 571
Cdd:TIGR01243 291 TGevekrVVAQLLTLMDGLKG-RGR-VIVIGATNRPDALDPALRRpgRFDREIVIRVPDKRARKEILKVHTRNMPLA-ED 367

                         170       180
                  ....*....|....*....|....*....
gi 568993097  572 RELAALVQGTQGFSGGELGQLCQQAAAEA 600
Cdd:TIGR01243 368 VDLDKLAEVTHGFVGADLAALAKEAAMAA 396
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 419-546 4.49e-22

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 93.12  E-value: 4.49e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 419 PPRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARLLQAAFAAARCRPPAVLLISELDALLPAR--- 495
Cdd:cd19511   26 PPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIFQKARQAAPCIIFFDEIDSLAPRRgqs 105

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 568993097 496 -DDGASLR--APLLTCLDGSCGARadGVLVVGTTSRPAALDEATRR--RFALRFYV 546
Cdd:cd19511  106 dSSGVTDRvvSQLLTELDGIESLK--GVVVIAATNRPDMIDPALLRpgRLDKLIYV 159
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 419-641 4.55e-21

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 95.67  E-value: 4.55e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 419 PPRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARLLQAAFAAARCRPPAVLLISELDALLPAR-DD 497
Cdd:PRK03992 164 PPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFIGEGARLVRELFELAREKAPSIIFIDEIDAIAAKRtDS 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 498 GASLRAP-------LLTCLDGsCGARADgVLVVGTTSRPAALDEATRR--RFALRFYVALPDGAARGQILQraLAQQGCA 568
Cdd:PRK03992 244 GTSGDREvqrtlmqLLAEMDG-FDPRGN-VKIIAATNRIDILDPAILRpgRFDRIIEVPLPDEEGRLEILK--IHTRKMN 319

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 569 LNE----RELAALvqgTQGFSGGELGQLCqqaaAEAGISGLQRPLSY---KDVEAALAKVGSrapSKELDSLVEWDKMYG 641
Cdd:PRK03992 320 LADdvdlEELAEL---TEGASGADLKAIC----TEAGMFAIRDDRTEvtmEDFLKAIEKVMG---KEEKDSMEEPGVMFA 389
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 419-546 1.38e-20

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 89.02  E-value: 1.38e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 419 PPRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARLLQAAFAAARCRPPAVLLISELDALLPARDDG 498
Cdd:cd19520   34 PPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQKLVAAVFSLASKLQPSIIFIDEIDSFLRQRSST 113

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568993097 499 -----ASLRAPLLTCLDGSCGARADGVLVVGTTSRPAALDEATRRRFALRFYV 546
Cdd:cd19520  114 dheatAMMKAEFMSLWDGLSTDGNCRVIVMGATNRPQDLDEAILRRMPKRFHI 166
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 418-540 7.39e-19

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 84.38  E-value: 7.39e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 418 LPPRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARLLQAAFAAARCRPPAVLLISELDALLPARdD 497
Cdd:cd19518   32 EPPRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESEEKIRELFDQAISNAPCIVFIDEIDAITPKR-E 110

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568993097 498 GAS------LRAPLLTCLD--GSCGARADGVLVVGTTSRPAALDEATRR--RF 540
Cdd:cd19518  111 SAQremerrIVSQLLTCMDelNNEKTAGGPVLVIGATNRPDSLDPALRRagRF 163
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 419-540 1.15e-17

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 80.56  E-value: 1.15e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 419 PPRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARLLQAAFAAARCRPPAVLLISELDALLPARDDG 498
Cdd:cd19519   33 PPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDEIDAIAPKREKT 112

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 568993097 499 AS-----LRAPLLTCLDGsCGARADgVLVVGTTSRPAALDEATRR--RF 540
Cdd:cd19519  113 HGeverrIVSQLLTLMDG-LKQRAH-VIVMAATNRPNSIDPALRRfgRF 159
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 419-546 4.40e-17

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 78.69  E-value: 4.40e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 419 PPRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARLLQAAFAAARCRPPAVLLISELDALLPAR--- 495
Cdd:cd19529   26 PPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIREIFRKARQVAPCVIFFDEIDSIAPRRgtt 105

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 568993097 496 -DDGASLRA--PLLTCLDGScgARADGVLVVGTTSRPAALDEATRR--RFALRFYV 546
Cdd:cd19529  106 gDSGVTERVvnQLLTELDGL--EEMNGVVVIAATNRPDIIDPALLRagRFDRLIYI 159
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 419-546 4.92e-17

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 79.26  E-value: 4.92e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 419 PPRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARLLQAAFAAARCRPPAVLLISELDALLPARDDG 498
Cdd:cd19522   32 PWKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTS 111

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568993097 499 ----ASLR--APLLTCLDGSCGARADG-----VLVVGTTSRPAALDEATRRRFALRFYV 546
Cdd:cd19522  112 eeheASRRvkSELLVQMDGVGGASENDdpskmVMVLAATNFPWDIDEALRRRLEKRIYI 170
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
420-621 7.57e-17

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 84.32  E-value: 7.57e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 420 PRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARLLQAAFAAARCRPPAVLLISELDALlpARDDGA 499
Cdd:PRK10733 185 PKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQAKKAAPCIIFIDEIDAV--GRQRGA 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 500 SLRA----------PLLTCLDGSCGAraDGVLVVGTTSRPAALDEATRR--RFALRFYVALPDGAARGQILQRALAQQGC 567
Cdd:PRK10733 263 GLGGghdereqtlnQMLVEMDGFEGN--EGIIVIAATNRPDVLDPALLRpgRFDRQVVVGLPDVRGREQILKVHMRRVPL 340

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568993097 568 AlNERELAALVQGTQGFSGGELGQLCQQAAAEAGiSGLQRPLSYKDVEAALAKV 621
Cdd:PRK10733 341 A-PDIDAAIIARGTPGFSGADLANLVNEAALFAA-RGNKRVVSMVEFEKAKDKI 392
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 419-540 1.03e-16

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 78.15  E-value: 1.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 419 PPRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARLLQAAFAAARCRPPAVLLISELDALLPAR-DD 497
Cdd:cd19502   36 PPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGEGARLVRELFEMAREKAPSIIFIDEIDAIGAKRfDS 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568993097 498 GASLRAP-------LLTCLDGsCGARADgVLVVGTTSRPAALDEATRR--RF 540
Cdd:cd19502  116 GTGGDREvqrtmleLLNQLDG-FDPRGN-IKVIMATNRPDILDPALLRpgRF 165
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 420-546 1.23e-15

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 74.83  E-value: 1.23e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 420 PRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARLLQAAFAAARCRPPAVLLISELDALLPARDDGA 499
Cdd:cd19530   30 PTGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVRQVFQRARASAPCVIFFDEVDALVPKRGDGG 109

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568993097 500 S-----LRAPLLTCLDGSCGARadGVLVVGTTSRPAALDEATRR--RFALRFYV 546
Cdd:cd19530  110 SwaserVVNQLLTEMDGLEERS--NVFVIAATNRPDIIDPAMLRpgRLDKTLYV 161
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 419-538 1.06e-14

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 72.16  E-value: 1.06e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 419 PPRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARLLQAAFAAARCRPPAVLLISELDALLPAR--- 495
Cdd:cd19528   26 PSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKARAAAPCVLFFDELDSIAKARggn 105

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 568993097 496 ---DDGASLRA--PLLTCLDGSCGARadGVLVVGTTSRPAALDEATRR 538
Cdd:cd19528  106 igdAGGAADRVinQILTEMDGMNTKK--NVFIIGATNRPDIIDPAILR 151
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 419-600 7.72e-14

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 73.64  E-value: 7.72e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 419 PPRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARLLQAAFAAARCRPPAVLLISELDALLPARDD- 497
Cdd:PTZ00454 178 PPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQKYLGEGPRMVRDVFRLARENAPSIIFIDEVDSIATKRFDa 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 498 --GAS-----LRAPLLTCLDGScgARADGVLVVGTTSRPAALDEATRR--RFALRFYVALPDGAARGQILQRALAQQGCA 568
Cdd:PTZ00454 258 qtGADrevqrILLELLNQMDGF--DQTTNVKVIMATNRADTLDPALLRpgRLDRKIEFPLPDRRQKRLIFQTITSKMNLS 335

                        170       180       190
                 ....*....|....*....|....*....|..
gi 568993097 569 lNERELAALVQGTQGFSGGELGQLCQQAAAEA 600
Cdd:PTZ00454 336 -EEVDLEDFVSRPEKISAADIAAICQEAGMQA 366
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 419-545 1.98e-13

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 68.69  E-value: 1.98e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 419 PPRTVLFFGPRGCGKALLGRCLATRLGA-----TLLRLRGAGLAASGAVEGARLLQAAFAAARCRPPAVLLISELDALLP 493
Cdd:cd19517   33 PPRGVLFHGPPGTGKTLMARALAAECSKggqkvSFFMRKGADCLSKWVGEAERQLRLLFEEAYRMQPSIIFFDEIDGLAP 112

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568993097 494 ARDDG-----ASLRAPLLTCLDGsCGARADgVLVVGTTSRPAALDEATRR--RFALRFY 545
Cdd:cd19517  113 VRSSKqeqihASIVSTLLALMDG-LDNRGQ-VVVIGATNRPDALDPALRRpgRFDREFY 169
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 423-546 8.49e-13

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 66.38  E-value: 8.49e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 423 VLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARLLQAAFAAARCRPPAVLLISELDALLPARDDGAS-- 500
Cdd:cd19527   29 ILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQKARDAKPCVIFFDELDSLAPSRGNSGDsg 108

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568993097 501 -----LRAPLLTCLDGSCGArADGVLVVGTTSRPAALDEATRR--RFALRFYV 546
Cdd:cd19527  109 gvmdrVVSQLLAELDGMSSS-GQDVFVIGATNRPDLLDPALLRpgRFDKLLYL 160
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 419-548 5.37e-12

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 64.09  E-value: 5.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 419 PPRTVLFFGPRGCGKALLGRCLATRL---GATLLRLRGAGLAASGAVEGAR---LLQAAFAAARCRPPAVLLISELDAlL 492
Cdd:cd00009   18 PPKNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGLVVAELFghfLVRLLFELAEKAKPGVLFIDEIDS-L 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568993097 493 PARDDGASLRApLLTCLDGscGARADGVLVVGTTSRPAA--LDEATRRRFALRFYVAL 548
Cdd:cd00009   97 SRGAQNALLRV-LETLNDL--RIDRENVRVIGATNRPLLgdLDRALYDRLDIRIVIPL 151
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 417-546 9.54e-12

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 63.79  E-value: 9.54e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 417 ALPPRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGaglaaSGAVE-----GARLLQAAFAAARCRPPAVLLISELDAL 491
Cdd:cd19501   34 AKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISG-----SDFVEmfvgvGASRVRDLFEQAKKNAPCIVFIDEIDAV 108

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568993097 492 LPARDDGAS---------LRApLLTCLDGScgARADGVLVVGTTSRPAALDEATRR--RFALRFYV 546
Cdd:cd19501  109 GRKRGAGLGgghdereqtLNQ-LLVEMDGF--ESNTGVIVIAATNRPDVLDPALLRpgRFDRQVYV 171
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 419-606 1.14e-11

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 67.10  E-value: 1.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 419 PPRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARLLQAAFAAARCRPPAVLLISELDALLPARDDG 498
Cdd:PTZ00361 216 PPKGVILYGPPGTGKTLLAKAVANETSATFLRVVGSELIQKYLGDGPKLVRELFRVAEENAPSIVFIDEIDAIGTKRYDA 295

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 499 ASLRA--------PLLTCLDGScGARADgVLVVGTTSRPAALDEATRR--RFALRFYVALPDGAARGQILQRALAQQGCA 568
Cdd:PTZ00361 296 TSGGEkeiqrtmlELLNQLDGF-DSRGD-VKVIMATNRIESLDPALIRpgRIDRKIEFPNPDEKTKRRIFEIHTSKMTLA 373

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 568993097 569 lNERELAALVQGTQGFSGGELGQLCqqaaAEAGISGLQ 606
Cdd:PTZ00361 374 -EDVDLEEFIMAKDELSGADIKAIC----TEAGLLALR 406
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 410-538 1.18e-11

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 63.22  E-value: 1.18e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 410 PPACPGSALPPRT-VLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAAS--GAVE-GARLLqaaFAAARCRPPAVLLI 485
Cdd:cd19526   16 PKIFASSPLRLRSgILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKyiGASEqNVRDL---FSRAQSAKPCILFF 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568993097 486 SELDALLPAR---DDGASLRA--PLLTCLDGSCGarADGVLVVGTTSRPAALDEATRR 538
Cdd:cd19526   93 DEFDSIAPKRghdSTGVTDRVvnQLLTQLDGVEG--LDGVYVLAATSRPDLIDPALLR 148
ftsH CHL00176
cell division protein; Validated
 416-597 8.13e-10

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 61.99  E-value: 8.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 416 SALPPRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGaglaaSGAVE-----GARLLQAAFAAARCRPPAVLLISELDA 490
Cdd:CHL00176 212 GAKIPKGVLLVGPPGTGKTLLAKAIAGEAEVPFFSISG-----SEFVEmfvgvGAARVRDLFKKAKENSPCIVFIDEIDA 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 491 LlpARDDGASLRA----------PLLTCLDGSCGARadGVLVVGTTSRPAALDEATRR--RFALRFYVALPDGAARGQIL 558
Cdd:CHL00176 287 V--GRQRGAGIGGgndereqtlnQLLTEMDGFKGNK--GVIVIAATNRVDILDAALLRpgRFDRQITVSLPDREGRLDIL 362

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 568993097 559 qRALAQQGCALNERELAALVQGTQGFSGGELGQLCQQAA 597
Cdd:CHL00176 363 -KVHARNKKLSPDVSLELIARRTPGFSGADLANLLNEAA 400
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 419-550 4.44e-09

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 55.46  E-value: 4.44e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097   419 PPRTVLFFGPRGCGKALLGRCLATRLGAT-----------------LLRLRGAGLAASGAVEGARLLQAAFAAARCRPPA 481
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPgggviyidgedileevlDQLLLIIVGGKKASGSGELRLRLALALARKLKPD 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097   482 VLLISELDALLPARDDGASLRAPLLTCLDGScgARADGVLVVGTTSRPAALDEA-TRRRFALRFYVALPD 550
Cdd:smart00382  81 VLILDEITSLLDAEQEALLLLLEELRLLLLL--KSEKNLTVILTTNDEKDLGPAlLRRRFDRRIVLLLIL 148
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
420-621 3.73e-06

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 50.04  E-value: 3.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 420 PRTVLFFGPRGCGKALLGRCLAtrlgatllrlrG-AG---LAASGA--VE-----GA---RLLqaaFAAARCRPPAVLLI 485
Cdd:COG0465  175 PKGVLLVGPPGTGKTLLAKAVA-----------GeAGvpfFSISGSdfVEmfvgvGAsrvRDL---FEQAKKNAPCIIFI 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 486 SELDALLPARDDGAS---------LRApLLTCLDGScGARaDGVLVVGTTSRPAALDEATRR--RFALRFYVALPDGAAR 554
Cdd:COG0465  241 DEIDAVGRQRGAGLGgghdereqtLNQ-LLVEMDGF-EGN-EGVIVIAATNRPDVLDPALLRpgRFDRQVVVDLPDVKGR 317

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568993097 555 GQILQ-----RALAQqgcalnERELAALVQGTQGFSGGELGQLCQQAA---AEAGisglQRPLSYKDVEAALAKV 621
Cdd:COG0465  318 EAILKvharkKPLAP------DVDLEVIARRTPGFSGADLANLVNEAAllaARRN----KKAVTMEDFEEAIDRV 382
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 410-489 1.92e-05

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 45.44  E-value: 1.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 410 PPACPGSALPPRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARLLQAAFAAARCRPPAVLLISELD 489
Cdd:cd19507   21 KQASAYGLPTPKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLVGESESRLRQMIQTAEAIAPCVLWIDEIE 100
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
 421-529 1.34e-03

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 39.82  E-value: 1.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993097 421 RTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAAS--GAVEGARLLQAAFAAARCRPPAVLLISELDALL------ 492
Cdd:cd19506   27 KSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKypGKNGLQMMLHLVLKVARQLQPSVIWIGDAEKTFykkvpk 106

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 568993097 493 -PARDDGASLRAPLLTCLDGScgARADGVLVVGTTSRP 529
Cdd:cd19506  107 tEKQLDPKRLKKDLPKILKSL--KPEDRVLIVGTTSRP 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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