LETM1/MDM38 family protein similar to Homo sapiens LETM1 domain-containing protein 1 that plays an essential role for mitochondrial structure and function, as well as thermogenesis of brown adipocytes
LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a ...
1-193
5.52e-52
LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a role in potassium and hydrogen ion exchange. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans. This entry represents the ribosome-binding domain (RBD) of LETM1/MDM38 proteins.
The actual alignment was detected with superfamily member pfam07766:
Pssm-ID: 462258 [Multi-domain] Cd Length: 229 Bit Score: 166.89 E-value: 5.52e-52
LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a ...
1-193
5.52e-52
LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a role in potassium and hydrogen ion exchange. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans. This entry represents the ribosome-binding domain (RBD) of LETM1/MDM38 proteins.
Pssm-ID: 462258 [Multi-domain] Cd Length: 229 Bit Score: 166.89 E-value: 5.52e-52
LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a ...
1-193
5.52e-52
LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a role in potassium and hydrogen ion exchange. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans. This entry represents the ribosome-binding domain (RBD) of LETM1/MDM38 proteins.
Pssm-ID: 462258 [Multi-domain] Cd Length: 229 Bit Score: 166.89 E-value: 5.52e-52
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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