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Conserved domains on  [gi|569011295|ref|XP_006528577|]
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tRNA (uracil-5-)-methyltransferase homolog B isoform X1 [Mus musculus]

Protein Classification

class I SAM-dependent RNA methyltransferase( domain architecture ID 11455144)

class I SAM-dependent RNA methyltransferase catalyzes the methylation of a specific RNA substrate using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0001510|GO:0046872|GO:0008757|GO:1904047
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 245-447 3.74e-58

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 195.39  E-value: 3.74e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295 245 GEPHIFEDLLGLKIRISPDAFFQINTAGAEMLYRIIGELSGVNSESLLLDICCGTGVIGLSVAQRASQVHGIELVEQAVE 324
Cdd:COG2265  190 GRDYLTERLGGLTFRISPGSFFQVNPEQAEALYAAALEWLDLTGGERVLDLYCGVGTFALPLARRAKKVIGVEIVPEAVE 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295 325 DARWTAAFNGVTNCEFHAGRAETILPQLLksqKDEKLTVAVVNPARAGLHYRVVRAIRNCRtIHTLVFVSCKPhgeST-- 402
Cdd:COG2265  270 DARENARLNGLKNVEFVAGDLEEVLPELL---WGGRPDVVVLDPPRAGAGPEVLEALAALG-PRRIVYVSCNP---ATla 342

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 569011295 403 RNfielccppnsAKQLLGDPFVLREAVPVDLFPHTPHCELVLLFT 447
Cdd:COG2265  343 RD----------LALLVEGGYRLEKVQPVDMFPHTHHVESVALLE 377
 
Name Accession Description Interval E-value
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 245-447 3.74e-58

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 195.39  E-value: 3.74e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295 245 GEPHIFEDLLGLKIRISPDAFFQINTAGAEMLYRIIGELSGVNSESLLLDICCGTGVIGLSVAQRASQVHGIELVEQAVE 324
Cdd:COG2265  190 GRDYLTERLGGLTFRISPGSFFQVNPEQAEALYAAALEWLDLTGGERVLDLYCGVGTFALPLARRAKKVIGVEIVPEAVE 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295 325 DARWTAAFNGVTNCEFHAGRAETILPQLLksqKDEKLTVAVVNPARAGLHYRVVRAIRNCRtIHTLVFVSCKPhgeST-- 402
Cdd:COG2265  270 DARENARLNGLKNVEFVAGDLEEVLPELL---WGGRPDVVVLDPPRAGAGPEVLEALAALG-PRRIVYVSCNP---ATla 342

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 569011295 403 RNfielccppnsAKQLLGDPFVLREAVPVDLFPHTPHCELVLLFT 447
Cdd:COG2265  343 RD----------LALLVEGGYRLEKVQPVDMFPHTHHVESVALLE 377
rumA TIGR00479
23S rRNA (uracil-5-)-methyltransferase RumA; This protein family was first proposed to be RNA ...
 95-441 1.90e-33

23S rRNA (uracil-5-)-methyltransferase RumA; This protein family was first proposed to be RNA methyltransferases by homology to the TrmA family. The member from E. coli has now been shown to act as the 23S RNA methyltransferase for the conserved U1939. The gene is now designated rumA and was previously designated ygcA. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129571 [Multi-domain]  Cd Length: 431  Bit Score: 130.33  E-value: 1.90e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295   95 GYRNKSTFSVYRSPDGNPKTVGYYLGTWKDGNVVCLPCNH---------LKNIPEKHSQVAQYYEVflrqssvepcllfh 165
Cdd:TIGR00479 112 GYRNKARLSLGRSPSGQLQAGFYQKGSHDIVDVKQCPVQApalnallpkVRAILENFGASRYLEHK-------------- 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295  166 EGGHWRELVVRTNRQGHTMAIV--TFHpQGLSEEEVCVQKVTlKDFftKGPGAIC-----ELTSLYFQESTMTrcshqqs 238
Cdd:TIGR00479 178 ELGQARHGVLRIGRHTGELSSVdrTAL-ERFPHKEELDLYLQ-PDS--PDVKSICqninpEKTNVIFGEETEV------- 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295  239 pyqlLFGEPHIFEDLLGLKIRISPDAFFQINTAGAEMLYRIIGELSGVNSESLLLDICCGTGVIGLSVAQRASQVHGIEL 318
Cdd:TIGR00479 247 ----IAGEMPIYDKSGDLSFTFSARDFIQVNSGQNEKLVDRALEWLELQGEERVLDAYCGMGTFTLPLAKQAKSVVGVEG 322

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295  319 VEQAVEDARWTAAFNGVTNCEFHAGRAETILPQLlkSQKDEKLTVAVVNPARAGLHYRVVRAIRNCRTIHtLVFVSCKPh 398
Cdd:TIGR00479 323 VPESVEKAQQNAELNGIANVTFYHGTLETVLPKQ--PWAGNGFDKVLLDPPRKGCAAGVLRTIIKLKPER-IVYVSCNP- 398

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 569011295  399 GESTRNfielccppnsAKQLLGDPFVLREAVPVDLFPHTPHCE 441
Cdd:TIGR00479 399 ATLARD----------LEALCKAGYTIARVQPVDMFPHTGHVE 431
rumB PRK03522
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;
245-445 6.18e-17

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;


Pssm-ID: 235128 [Multi-domain]  Cd Length: 315  Bit Score: 81.07  E-value: 6.18e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295 245 GEPHIF--------EDLLGLKIRISPDAFFQINTAGAEMLYRI----IGELsGVNSeslLLDICCGTGVIGLSVAQRASQ 312
Cdd:PRK03522 122 GEEEIFlteqqalpERFNGVPLFIRPQSFFQTNPAVAAQLYATardwVREL-PPRS---MWDLFCGVGGFGLHCATPGMQ 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295 313 VHGIELVEQAVEDARWTAAFNGVTNCEFHAGRAETILpqllkSQKDEKLTVAVVNPARAGLHYRVVRAIrNCRTIHTLVF 392
Cdd:PRK03522 198 LTGIEISAEAIACAKQSAAELGLTNVQFQALDSTQFA-----TAQGEVPDLVLVNPPRRGIGKELCDYL-SQMAPRFILY 271

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 569011295 393 VSCKPHgestrnfielccppNSAKQLLGDP-FVLREAVPVDLFPHTPHCE-LVLL 445
Cdd:PRK03522 272 SSCNAQ--------------TMAKDLAHLPgYRIERVQLFDMFPHTAHYEvLTLL 312
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 293-385 1.81e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 51.80  E-value: 1.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295  293 LDICCGTGVIGLSVAQRA-SQVHGIELVEQAVEDARWTAAFNGVtNCEFHAGRAETIlpqllkSQKDEKLTVAVvnpARA 371
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGgARVTGVDLSPEMLERARERAAEAGL-NVEFVQGDAEDL------PFPDGSFDLVV---SSG 71

                          90
                  ....*....|....*...
gi 569011295  372 GLHY----RVVRAIRNCR 385
Cdd:pfam13649  72 VLHHlpdpDLEAALREIA 89
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 292-385 1.95e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 52.05  E-value: 1.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295 292 LLDICCGTGVIGLSVAQR-ASQVHGIELVEQAVEDARWTAAFNGVTNCEFHAGRAETILPqllksQKDEKLTVAVVNPAR 370
Cdd:cd02440    2 VLDLGCGTGALALALASGpGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPP-----EADESFDVIISDPPL 76

                         90
                 ....*....|....*
gi 569011295 371 AGLHYRVVRAIRNCR 385
Cdd:cd02440   77 HHLVEDLARFLEEAR 91
 
Name Accession Description Interval E-value
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 245-447 3.74e-58

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 195.39  E-value: 3.74e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295 245 GEPHIFEDLLGLKIRISPDAFFQINTAGAEMLYRIIGELSGVNSESLLLDICCGTGVIGLSVAQRASQVHGIELVEQAVE 324
Cdd:COG2265  190 GRDYLTERLGGLTFRISPGSFFQVNPEQAEALYAAALEWLDLTGGERVLDLYCGVGTFALPLARRAKKVIGVEIVPEAVE 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295 325 DARWTAAFNGVTNCEFHAGRAETILPQLLksqKDEKLTVAVVNPARAGLHYRVVRAIRNCRtIHTLVFVSCKPhgeST-- 402
Cdd:COG2265  270 DARENARLNGLKNVEFVAGDLEEVLPELL---WGGRPDVVVLDPPRAGAGPEVLEALAALG-PRRIVYVSCNP---ATla 342

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 569011295 403 RNfielccppnsAKQLLGDPFVLREAVPVDLFPHTPHCELVLLFT 447
Cdd:COG2265  343 RD----------LALLVEGGYRLEKVQPVDMFPHTHHVESVALLE 377
rumA TIGR00479
23S rRNA (uracil-5-)-methyltransferase RumA; This protein family was first proposed to be RNA ...
 95-441 1.90e-33

23S rRNA (uracil-5-)-methyltransferase RumA; This protein family was first proposed to be RNA methyltransferases by homology to the TrmA family. The member from E. coli has now been shown to act as the 23S RNA methyltransferase for the conserved U1939. The gene is now designated rumA and was previously designated ygcA. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129571 [Multi-domain]  Cd Length: 431  Bit Score: 130.33  E-value: 1.90e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295   95 GYRNKSTFSVYRSPDGNPKTVGYYLGTWKDGNVVCLPCNH---------LKNIPEKHSQVAQYYEVflrqssvepcllfh 165
Cdd:TIGR00479 112 GYRNKARLSLGRSPSGQLQAGFYQKGSHDIVDVKQCPVQApalnallpkVRAILENFGASRYLEHK-------------- 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295  166 EGGHWRELVVRTNRQGHTMAIV--TFHpQGLSEEEVCVQKVTlKDFftKGPGAIC-----ELTSLYFQESTMTrcshqqs 238
Cdd:TIGR00479 178 ELGQARHGVLRIGRHTGELSSVdrTAL-ERFPHKEELDLYLQ-PDS--PDVKSICqninpEKTNVIFGEETEV------- 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295  239 pyqlLFGEPHIFEDLLGLKIRISPDAFFQINTAGAEMLYRIIGELSGVNSESLLLDICCGTGVIGLSVAQRASQVHGIEL 318
Cdd:TIGR00479 247 ----IAGEMPIYDKSGDLSFTFSARDFIQVNSGQNEKLVDRALEWLELQGEERVLDAYCGMGTFTLPLAKQAKSVVGVEG 322

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295  319 VEQAVEDARWTAAFNGVTNCEFHAGRAETILPQLlkSQKDEKLTVAVVNPARAGLHYRVVRAIRNCRTIHtLVFVSCKPh 398
Cdd:TIGR00479 323 VPESVEKAQQNAELNGIANVTFYHGTLETVLPKQ--PWAGNGFDKVLLDPPRKGCAAGVLRTIIKLKPER-IVYVSCNP- 398

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 569011295  399 GESTRNfielccppnsAKQLLGDPFVLREAVPVDLFPHTPHCE 441
Cdd:TIGR00479 399 ATLARD----------LEALCKAGYTIARVQPVDMFPHTGHVE 431
rumB PRK03522
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;
245-445 6.18e-17

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;


Pssm-ID: 235128 [Multi-domain]  Cd Length: 315  Bit Score: 81.07  E-value: 6.18e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295 245 GEPHIF--------EDLLGLKIRISPDAFFQINTAGAEMLYRI----IGELsGVNSeslLLDICCGTGVIGLSVAQRASQ 312
Cdd:PRK03522 122 GEEEIFlteqqalpERFNGVPLFIRPQSFFQTNPAVAAQLYATardwVREL-PPRS---MWDLFCGVGGFGLHCATPGMQ 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295 313 VHGIELVEQAVEDARWTAAFNGVTNCEFHAGRAETILpqllkSQKDEKLTVAVVNPARAGLHYRVVRAIrNCRTIHTLVF 392
Cdd:PRK03522 198 LTGIEISAEAIACAKQSAAELGLTNVQFQALDSTQFA-----TAQGEVPDLVLVNPPRRGIGKELCDYL-SQMAPRFILY 271

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 569011295 393 VSCKPHgestrnfielccppNSAKQLLGDP-FVLREAVPVDLFPHTPHCE-LVLL 445
Cdd:PRK03522 272 SSCNAQ--------------TMAKDLAHLPgYRIERVQLFDMFPHTAHYEvLTLL 312
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 292-381 9.08e-12

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 63.67  E-value: 9.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295 292 LLDICCGTGVIGLSVAQRA--SQVHGIELVEQAVEDARWTAAFNGVTNCEFHAgraetilPQLLKSQKDEKLTVAVVN-P 368
Cdd:COG2813   53 VLDLGCGYGVIGLALAKRNpeARVTLVDVNARAVELARANAAANGLENVEVLW-------SDGLSGVPDGSFDLILSNpP 125

                         90
                 ....*....|....*
gi 569011295 369 ARAGL--HYRVVRAI 381
Cdd:COG2813  126 FHAGRavDKEVAHAL 140
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 292-368 1.09e-09

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 58.62  E-value: 1.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295 292 LLDICCGTGVIGLSVAQR--ASQVHGIELVEQAVEDARWTAAFNGVTN-CEFHAGRaetiLPQLLKSQKDEKLTVAVVNP 368
Cdd:COG4123   41 VLDLGTGTGVIALMLAQRspGARITGVEIQPEAAELARRNVALNGLEDrITVIHGD----LKEFAAELPPGSFDLVVSNP 116
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 293-385 1.81e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 51.80  E-value: 1.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295  293 LDICCGTGVIGLSVAQRA-SQVHGIELVEQAVEDARWTAAFNGVtNCEFHAGRAETIlpqllkSQKDEKLTVAVvnpARA 371
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGgARVTGVDLSPEMLERARERAAEAGL-NVEFVQGDAEDL------PFPDGSFDLVV---SSG 71

                          90
                  ....*....|....*...
gi 569011295  372 GLHY----RVVRAIRNCR 385
Cdd:pfam13649  72 VLHHlpdpDLEAALREIA 89
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 292-385 1.95e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 52.05  E-value: 1.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295 292 LLDICCGTGVIGLSVAQR-ASQVHGIELVEQAVEDARWTAAFNGVTNCEFHAGRAETILPqllksQKDEKLTVAVVNPAR 370
Cdd:cd02440    2 VLDLGCGTGALALALASGpGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPP-----EADESFDVIISDPPL 76

                         90
                 ....*....|....*
gi 569011295 371 AGLHYRVVRAIRNCR 385
Cdd:cd02440   77 HHLVEDLARFLEEAR 91
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 293-381 2.53e-08

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 53.36  E-value: 2.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295  293 LDICCGTGVIGLSVAQRASQVHgIELVE---QAVEDARWTAAFNGVTNCEFHAGraetilpQLLKSQKDEKLTVAVVNPA 369
Cdd:pfam05175  36 LDLGCGAGVLGAALAKESPDAE-LTMVDinaRALESARENLAANGLENGEVVAS-------DVYSGVEDGKFDLIISNPP 107

                          90
                  ....*....|....*
gi 569011295  370 -RAGLH--YRVVRAI 381
Cdd:pfam05175 108 fHAGLAttYNVAQRF 122
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 292-357 2.62e-08

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 52.80  E-value: 2.62e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569011295  292 LLDICCGTGVIGLSVAQRA---SQVHGIELVEQAVEDARWTAAFNGVTNCEFHAGRAETiLPQLLKSQK 357
Cdd:pfam13847   7 VLDLGCGTGHLSFELAEELgpnAEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEE-LPELLEDDK 74
tRNA_U5-meth_tr pfam05958
tRNA (Uracil-5-)-methyltransferase; This family consists of (Uracil-5-)-methyltransferases EC: ...
 263-448 1.35e-07

tRNA (Uracil-5-)-methyltransferase; This family consists of (Uracil-5-)-methyltransferases EC:2.1.1.35 from bacteria, archaea and eukaryotes. A 5-methyluridine (m(5)U) residue at position 54 is a conserved feature of bacterial and eukaryotic tRNAs. The methylation of U54 is catalyzed by the tRNA(m5U54)methyltransferase, which in Saccharomyces cerevisiae is encoded by the nonessential TRM2 gene. It is thought that tRNA modification enzymes might have a role in tRNA maturation not necessarily linked to their known catalytic activity.


Pssm-ID: 428692  Cd Length: 357  Bit Score: 53.21  E-value: 1.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295  263 DAFFQINTAGAE-ML---YRIIGelsgvNSESLLLDICCGTGVIGLSVAQRASQVHGIELVEQAVEDARWTAAFNGVTNC 338
Cdd:pfam05958 177 NSFTQPNAAVNIkMLewaCDVTQ-----GSKGDLLELYCGNGNFSLALARNFRKVLATEIAKPSVAAAQYNIAANNIDNV 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295  339 EFHAGRAETiLPQLLKSQ-----------KDEKLTVAVVNPARAGLHYRVVRAIRNCRTIhtlVFVSCKPHgestrnfiE 407
Cdd:pfam05958 252 QIIRMSAEE-FTQAMNGVrefnrlkgidlKSYNCSTIFVDPPRAGLDPETLKLVQAYPRI---LYISCNPE--------T 319

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 569011295  408 LCcppNSAKQLLGDPFVLREAVpVDLFPHTPHCELVLLFTR 448
Cdd:pfam05958 320 LC---ANLEQLSKTHRVERFAL-FDQFPYTHHMECGVLLEK 356
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 293-368 6.58e-07

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 50.55  E-value: 6.58e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569011295 293 LDICCGTGVIGLSVAQR--ASQVHGIELVEQAVEDARWTAAFNGVTNCEFHAGRaetilpqLLKSQKDEKLTVAVVNP 368
Cdd:PRK09328 113 LDLGTGSGAIALALAKErpDAEVTAVDISPEALAVARRNAKHGLGARVEFLQGD-------WFEPLPGGRFDLIVSNP 183
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 292-348 1.19e-06

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 47.68  E-value: 1.19e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 569011295 292 LLDICCGTGVIGLSVAQRASQVHGIELVEQAVEDARWTAAFNGVtNCEFHAGRAETI 348
Cdd:COG2226   26 VLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGL-NVEFVVGDAEDL 81
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 239-343 1.57e-06

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 49.38  E-value: 1.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295 239 PYQLLFGEphifEDLLGLKIRISPDAFfqI---NTAgaEMLYRIIGELSGvNSESLLLDICCGTGVIGLSVAQR--ASQV 313
Cdd:COG2890   69 PLAYILGE----AEFYGLEFKVDPGVL--IprpETE--ELVELALALLPA-GAPPRVLDLGTGSGAIALALAKErpDARV 139

                         90       100       110
                 ....*....|....*....|....*....|.
gi 569011295 314 HGIELVEQAVEDARWTAAFNGVTN-CEFHAG 343
Cdd:COG2890  140 TAVDISPDALAVARRNAERLGLEDrVRFLQG 170
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 293-350 9.33e-06

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 46.45  E-value: 9.33e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 569011295 293 LDICCGTGVIGLSVAQRA-SQVHGIELVEQAVEDARWTAAFNGVTNCEFHAGRAETILP 350
Cdd:COG0500   31 LDLGCGTGRNLLALAARFgGRVIGIDLSPEAIALARARAAKAGLGNVEFLVADLAELDP 89
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 292-348 1.19e-05

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 44.62  E-value: 1.19e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 569011295 292 LLDICCGTGVIGLSVAQRASQVHGIELVEQAVEDARWTAAFNGVtncEFHAGRAETI 348
Cdd:COG2227   28 VLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAELNV---DFVQGDLEDL 81
PRK05031 PRK05031
tRNA (uracil-5-)-methyltransferase; Validated
 263-445 5.99e-05

tRNA (uracil-5-)-methyltransferase; Validated


Pssm-ID: 235332  Cd Length: 362  Bit Score: 44.82  E-value: 5.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295 263 DAFFQINTAGAE-MLYRIIGELSgvNSESLLLDICCGTGVIGLSVAQRASQVHGIELVEQAVEDARWTAAFNGVTNCEFH 341
Cdd:PRK05031 182 NSFTQPNAAVNEkMLEWALDATK--GSKGDLLELYCGNGNFTLALARNFRRVLATEISKPSVAAAQYNIAANGIDNVQII 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295 342 AGRAETiLPQLLKSQ------KDEKL------TVaVVNPARAGLHYRVVRAIRNCRTIhtlVFVSCKPHgesT--RNFIE 407
Cdd:PRK05031 260 RMSAEE-FTQAMNGVrefnrlKGIDLksynfsTI-FVDPPRAGLDDETLKLVQAYERI---LYISCNPE---TlcENLET 331

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 569011295 408 LCcppNSAKqllgdpfVLREAVpVDLFPHTPHCEL-VLL 445
Cdd:PRK05031 332 LS---QTHK-------VERFAL-FDQFPYTHHMECgVLL 359
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
293-351 6.39e-05

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 41.73  E-value: 6.39e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569011295 293 LDICCGTGVIGLSVAQR--ASQVHGIELVEQAVEDARwtaafNGVTNCEFHAGRAETILPQ 351
Cdd:COG4106    6 LDLGCGTGRLTALLAERfpGARVTGVDLSPEMLARAR-----ARLPNVRFVVADLRDLDPP 61
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
293-327 1.52e-04

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 42.29  E-value: 1.52e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 569011295 293 LDICCGTGVIGLSVAQRASQVHGIELVEQAVEDAR 327
Cdd:COG4976   51 LDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAR 85
PRK14968 PRK14968
putative methyltransferase; Provisional
 293-368 3.05e-04

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 41.42  E-value: 3.05e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569011295 293 LDICCGTGVIGLSVAQRASQVHGIELVEQAVEDARWTAAFNGVTNCEFHAGRAEtilpqLLKSQKDEKLTVAVVNP 368
Cdd:PRK14968  28 LEVGTGSGIVAIVAAKNGKKVVGVDINPYAVECAKCNAKLNNIRNNGVEVIRSD-----LFEPFRGDKFDVILFNP 98
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
286-351 5.95e-04

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 41.18  E-value: 5.95e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569011295 286 VNSESLLLDICCGTGVIG-LSVAQRASQVHGIELVEQAVEDARWTAAFNGVT-NCEFHAGRAETILPQ 351
Cdd:COG4076   33 VKPGDVVLDIGTGSGLLSmLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSdRITVINADATDLDLP 100
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 290-352 6.88e-04

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 41.69  E-value: 6.88e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569011295 290 SLLLDICCGTGVIGLSVAQRA--SQVHGIELVEQAVEDARWTA-AFnGVTNCEFHAGRAETILPQL 352
Cdd:COG2242  249 DVLWDIGAGSGSVSIEAARLApgGRVYAIERDPERAALIRANArRF-GVPNVEVVEGEAPEALADL 313
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 293-399 2.84e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 36.87  E-value: 2.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295  293 LDICCGTGVIGLSVAQRASQVHGIELVEQAVEDARWTAAFNGVTnceFHAGRAETiLPqllksQKDEKLTVAVvnpARAG 372
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGLT---FVVGDAED-LP-----FPDNSFDLVL---SSEV 68

                          90       100
                  ....*....|....*....|....*....
gi 569011295  373 LHY--RVVRAIRNCRTIhtlvfvsCKPHG 399
Cdd:pfam08241  69 LHHveDPERALREIARV-------LKPGG 90
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
273-327 4.15e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 38.35  E-value: 4.15e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 569011295 273 AEMLY--RIIGELSGvnseSLLLDICCGTGVIGLSVAQR-ASQVHGIELVEQAVEDAR 327
Cdd:COG2263   32 AELLHlaYLRGDIEG----KTVLDLGCGTGMLAIGAALLgAKKVVGVDIDPEALEIAR 85
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
292-357 5.85e-03

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 38.62  E-value: 5.85e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569011295 292 LLDICCGTGVigLSVA---QRASQVHGIELVEQAVEDARWTAAFNGVtncefhAGRAETILPQLLKSQK 357
Cdd:COG2264  152 VLDVGCGSGI--LAIAaakLGAKRVLAVDIDPVAVEAARENAELNGV------EDRIEVVLGDLLEDGP 212
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 278-368 6.44e-03

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 37.62  E-value: 6.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011295 278 RIIGELSGVNSESLLLDICCGTGVIGLSVAQRASQVHGIELVEQAVEDARWTAAFNGVTNCEFHAGRAETIlpqllkSQK 357
Cdd:COG1041   16 RALVNLAGAKEGDTVLDPFCGTGTILIEAGLLGRRVIGSDIDPKMVEGARENLEHYGYEDADVIRGDARDL------PLA 89

                         90
                 ....*....|.
gi 569011295 358 DEKLTVAVVNP 368
Cdd:COG1041   90 DESVDAIVTDP 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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