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Conserved domains on  [gi|568972182|ref|XP_006532544|]
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period circadian protein homolog 1 isoform X2 [Mus musculus]

Protein Classification

PAS and Period_C domain-containing protein( domain architecture ID 12092810)

PAS and Period_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Period_C pfam12114
Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is ...
 1078-1197 5.12e-55

Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is typically between 164 to 200 amino acids in length. This domain is found associated with pfam08447.


:

Pssm-ID: 463464  Cd Length: 171  Bit Score: 189.15  E-value: 5.12e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972182  1078 ASITRSSQSSHTSKYFGSIDSSE-AEAGAARARTEPGDQVIKCVLQDPIWLLMANADQRVMMTYQVPSRDAASVLKQDRE 1156
Cdd:pfam12114   51 GSGTGSSDTSHSSKYFGSIDSSEnNHKAKKTAEVGEEEHFIKCVLQDPIWLLMANTDDSVMMTYQIPSRDLETVLKEDRE 130

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 568972182  1157 RLRAMQKQQPRFSEDQRRELGAVHSWVRKGQLPRALDVTAC 1197
Cdd:pfam12114  131 KLKAMQKMQPRFTEDQKGELAEVHPWIQKGGLPAALDLSEC 171
PAS_3 pfam08447
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 373-457 2.18e-11

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.


:

Pssm-ID: 430001 [Multi-domain]  Cd Length: 89  Bit Score: 61.20  E-value: 2.18e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972182   373 VDERAAPLLGYLPQDLLGAPVLL--FLHPEDRPLMLAIHKKILQlAGQPFDHsPIRFCARNGEYVTMDTSwAGFVHPWSR 450
Cdd:pfam08447    4 WSPRFEEILGYTPEELLGKGESWldLVHPDDRERVREALWEALK-GGEPYSG-EYRIRRKDGEYRWVEAR-ARPIRDENG 80


                   ....*..
gi 568972182   451 KVAFVLG 457
Cdd:pfam08447   81 KPVRVIG 87
 
Name Accession Description Interval E-value
Period_C pfam12114
Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is ...
 1078-1197 5.12e-55

Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is typically between 164 to 200 amino acids in length. This domain is found associated with pfam08447.


Pssm-ID: 463464  Cd Length: 171  Bit Score: 189.15  E-value: 5.12e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972182  1078 ASITRSSQSSHTSKYFGSIDSSE-AEAGAARARTEPGDQVIKCVLQDPIWLLMANADQRVMMTYQVPSRDAASVLKQDRE 1156
Cdd:pfam12114   51 GSGTGSSDTSHSSKYFGSIDSSEnNHKAKKTAEVGEEEHFIKCVLQDPIWLLMANTDDSVMMTYQIPSRDLETVLKEDRE 130

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 568972182  1157 RLRAMQKQQPRFSEDQRRELGAVHSWVRKGQLPRALDVTAC 1197
Cdd:pfam12114  131 KLKAMQKMQPRFTEDQKGELAEVHPWIQKGGLPAALDLSEC 171
PAS_3 pfam08447
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 373-457 2.18e-11

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.


Pssm-ID: 430001 [Multi-domain]  Cd Length: 89  Bit Score: 61.20  E-value: 2.18e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972182   373 VDERAAPLLGYLPQDLLGAPVLL--FLHPEDRPLMLAIHKKILQlAGQPFDHsPIRFCARNGEYVTMDTSwAGFVHPWSR 450
Cdd:pfam08447    4 WSPRFEEILGYTPEELLGKGESWldLVHPDDRERVREALWEALK-GGEPYSG-EYRIRRKDGEYRWVEAR-ARPIRDENG 80


                   ....*..
gi 568972182   451 KVAFVLG 457
Cdd:pfam08447   81 KPVRVIG 87
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 360-461 4.33e-10

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 58.03  E-value: 4.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972182  360 FTTRHTPSCLFQDVDERAAPLLGYLPQDLLGAPVLLFLHPEDRPLMLAIHKKILQlAGQPFDHsPIRFCARNGEYVTMDT 439
Cdd:cd00130     4 GVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLS-GGEPVTL-EVRLRRKDGSVIWVLV 81

                          90       100
                  ....*....|....*....|..
gi 568972182  440 SWAGFVHPWSRKVAFVLGRHKV 461
Cdd:cd00130    82 SLTPIRDEGGEVIGLLGVVRDI 103
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 360-414 1.41e-06

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 47.01  E-value: 1.41e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 568972182    360 FTTRHTPSCLFQDVDERAAPLLGYLPQDLLGAPVLLFLHPEDRPLMLAIHKKILQ 414
Cdd:smart00091   13 GIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEALQRLLS 67
PAS COG2202
PAS domain [Signal transduction mechanisms];
370-440 1.12e-03

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 42.32  E-value: 1.12e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568972182  370 FQDVDERAAPLLGYLPQDLLGAPVLLFLHPEDRPLMLAIHKKILQLAGQPFDHsPIRFCARNGEYVTMDTS 440
Cdd:COG2202   159 ILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLRRLLEGGRESYEL-ELRLKDGDGRWVWVEAS 228
 
Name Accession Description Interval E-value
Period_C pfam12114
Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is ...
 1078-1197 5.12e-55

Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is typically between 164 to 200 amino acids in length. This domain is found associated with pfam08447.


Pssm-ID: 463464  Cd Length: 171  Bit Score: 189.15  E-value: 5.12e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972182  1078 ASITRSSQSSHTSKYFGSIDSSE-AEAGAARARTEPGDQVIKCVLQDPIWLLMANADQRVMMTYQVPSRDAASVLKQDRE 1156
Cdd:pfam12114   51 GSGTGSSDTSHSSKYFGSIDSSEnNHKAKKTAEVGEEEHFIKCVLQDPIWLLMANTDDSVMMTYQIPSRDLETVLKEDRE 130

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 568972182  1157 RLRAMQKQQPRFSEDQRRELGAVHSWVRKGQLPRALDVTAC 1197
Cdd:pfam12114  131 KLKAMQKMQPRFTEDQKGELAEVHPWIQKGGLPAALDLSEC 171
PAS_3 pfam08447
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 373-457 2.18e-11

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.


Pssm-ID: 430001 [Multi-domain]  Cd Length: 89  Bit Score: 61.20  E-value: 2.18e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972182   373 VDERAAPLLGYLPQDLLGAPVLL--FLHPEDRPLMLAIHKKILQlAGQPFDHsPIRFCARNGEYVTMDTSwAGFVHPWSR 450
Cdd:pfam08447    4 WSPRFEEILGYTPEELLGKGESWldLVHPDDRERVREALWEALK-GGEPYSG-EYRIRRKDGEYRWVEAR-ARPIRDENG 80


                   ....*..
gi 568972182   451 KVAFVLG 457
Cdd:pfam08447   81 KPVRVIG 87
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 360-461 4.33e-10

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 58.03  E-value: 4.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972182  360 FTTRHTPSCLFQDVDERAAPLLGYLPQDLLGAPVLLFLHPEDRPLMLAIHKKILQlAGQPFDHsPIRFCARNGEYVTMDT 439
Cdd:cd00130     4 GVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLS-GGEPVTL-EVRLRRKDGSVIWVLV 81

                          90       100
                  ....*....|....*....|..
gi 568972182  440 SWAGFVHPWSRKVAFVLGRHKV 461
Cdd:cd00130    82 SLTPIRDEGGEVIGLLGVVRDI 103
PAS_11 pfam14598
PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), ...
 360-461 7.84e-10

PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).


Pssm-ID: 464214 [Multi-domain]  Cd Length: 110  Bit Score: 57.30  E-value: 7.84e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972182   360 FTTRHTPSCLFQDVDERAAPLLGYLPQDLLGAPVLLFLHPEDRPLMLAIHKKILQLAGQPFdhSPI-RFCARNGEYVTMD 438
Cdd:pfam14598    4 FTTRHDIDGKIISCDTRAPFSLGYEKDELVGRSIYDLVHPQDLRTAKSHLREIIQTRGRAT--SPSyRLRLRDGDFLSVH 81

                           90       100
                   ....*....|....*....|...
gi 568972182   439 TSWAGFVHPWSRKVAFVLGRHKV 461
Cdd:pfam14598   82 TKSKLFLNQNSNQQPFIMCTHTI 104
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 360-414 1.41e-06

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 47.01  E-value: 1.41e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 568972182    360 FTTRHTPSCLFQDVDERAAPLLGYLPQDLLGAPVLLFLHPEDRPLMLAIHKKILQ 414
Cdd:smart00091   13 GIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEALQRLLS 67
PAS pfam00989
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 373-456 8.72e-05

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395786 [Multi-domain]  Cd Length: 113  Bit Score: 43.17  E-value: 8.72e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972182   373 VDERAAPLLGYLPQDLLGAPVLLFLHPEDRPLMLAIHKKILQLAGQPFDHSpIRFCARNGEYVTMDTSWAGFVHPWSRKV 452
Cdd:pfam00989   26 VNAAAEELLGLSREEVIGKSLLDLIPEEDDAEVAELLRQALLQGEESRGFE-VSFRVPDGRPRHVEVRASPVRDAGGEIL 104


                   ....
gi 568972182   453 AFVL 456
Cdd:pfam00989  105 GFLG 108
PAS COG2202
PAS domain [Signal transduction mechanisms];
370-440 1.12e-03

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 42.32  E-value: 1.12e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568972182  370 FQDVDERAAPLLGYLPQDLLGAPVLLFLHPEDRPLMLAIHKKILQLAGQPFDHsPIRFCARNGEYVTMDTS 440
Cdd:COG2202   159 ILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLRRLLEGGRESYEL-ELRLKDGDGRWVWVEAS 228
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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