|
Name |
Accession |
Description |
Interval |
E-value |
| TLE_N |
pfam03920 |
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ... |
18-79 |
1.53e-48 |
|
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.
Pssm-ID: 461094 Cd Length: 117 Bit Score: 165.68 E-value: 1.53e-48
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568926378 18 FKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQS 79
Cdd:pfam03920 1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQT 62
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
363-648 |
4.25e-44 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 162.77 E-value: 4.25e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 363 HGEVVCAVTISNPTRHVYTGGK-GCVKVWDISHPGNKSPVSqldclNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAa 441
Cdd:COG2319 77 HTAAVLSVAFSPDGRLLASASAdGTVRLWDLATGLLLRTLT-----GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA- 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 442 pTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVR 521
Cdd:COG2319 151 -TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVR 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 522 SWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPD-KYQLHLHESCVLSLKFAYCGKWFVSTGKD 599
Cdd:COG2319 230 LWDLATGKLLRTlTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGElLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 568926378 600 NLLNAWRTPYGASIFQSK-ESSSVLSCDISVDDKYIVTGSGDKKATVYEV 648
Cdd:COG2319 310 GTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
363-647 |
2.60e-38 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 143.63 E-value: 2.60e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 363 HGEVVCAVTISNPTRHVYTGGK-GCVKVWDIShpgNKSPVSQLdCLNRDNyIRSCKLLPDGCTLIVGGEASTLSIWDLaa 441
Cdd:cd00200 8 HTGGVTCVAFSPDGKLLATGSGdGTIKVWDLE---TGELLRTL-KGHTGP-VRDVAASADGTYLASGSSDKTIRLWDL-- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 442 PTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVR 521
Cdd:cd00200 81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 522 SWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPD-KYQLHLHESCVLSLKFAYCGKWFVSTGKD 599
Cdd:cd00200 161 LWDLRTGKCVATlTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKcLGTLRGHENGVNSVAFSPDGYLLASGSED 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 568926378 600 NLLNAWRTPYGASIFQ-SKESSSVLSCDISVDDKYIVTGSGDKKATVYE 647
Cdd:cd00200 241 GTIRVWDLRTGECVQTlSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
485-524 |
3.22e-07 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 46.92 E-value: 3.22e-07
10 20 30 40
....*....|....*....|....*....|....*....|
gi 568926378 485 NQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWD 524
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
475-646 |
6.92e-07 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 52.40 E-value: 6.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 475 DGNIAVWDLHNQTLVRQFQGHTDGASCIDISN-DGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGY-CPTGEWL 552
Cdd:PLN00181 554 EGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFpSESGRSL 633
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 553 AVGMESSNVEVLHVNKPdkyQLHL-----HESCVLSLKFAYCGKwFVSTGKDNLLNAWRTPYGASIFQSKESSSVLS--- 624
Cdd:PLN00181 634 AFGSADHKVYYYDLRNP---KLPLctmigHSKTVSYVRFVDSST-LVSSSTDNTLKLWDLSMSISGINETPLHSFMGhtn 709
|
170 180
....*....|....*....|....*.
gi 568926378 625 ----CDISVDDKYIVTGSGDKKATVY 646
Cdd:PLN00181 710 vknfVGLSVSDGYIATGSETNEVFVY 735
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
487-524 |
3.99e-06 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 43.87 E-value: 3.99e-06
10 20 30
....*....|....*....|....*....|....*...
gi 568926378 487 TLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWD 524
Cdd:pfam00400 2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
185-347 |
7.01e-03 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 39.67 E-value: 7.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 185 HEKANTPVLKSSTPTPRSdmPTPGTSATPGLRPGLGKPPAMEPLVNQAAAGLRTPLavPGPYPAPFGMVPHAGMNGELTS 264
Cdd:PHA03378 671 HIPYQPSPTGANTMLPIQ--WAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRA--RPPAAAPGRARPPAAAPGRARP 746
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 265 PGAAYAGLHsmSPQMSAAAAaaaaavvaygRSPMVGFDPPPHMRVPSIPPNLAGIPGGKPAysfhvtadgQMQPVPFPPD 344
Cdd:PHA03378 747 PAAAPGRAR--PPAAAPGRA----------RPPAAAPGAPTPQPPPQAPPAPQQRPRGAPT---------PQPPPQAGPT 805
|
...
gi 568926378 345 ALI 347
Cdd:PHA03378 806 SMQ 808
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| TLE_N |
pfam03920 |
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ... |
18-79 |
1.53e-48 |
|
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.
Pssm-ID: 461094 Cd Length: 117 Bit Score: 165.68 E-value: 1.53e-48
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568926378 18 FKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQS 79
Cdd:pfam03920 1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQT 62
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
363-648 |
4.25e-44 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 162.77 E-value: 4.25e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 363 HGEVVCAVTISNPTRHVYTGGK-GCVKVWDISHPGNKSPVSqldclNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAa 441
Cdd:COG2319 77 HTAAVLSVAFSPDGRLLASASAdGTVRLWDLATGLLLRTLT-----GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA- 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 442 pTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVR 521
Cdd:COG2319 151 -TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVR 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 522 SWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPD-KYQLHLHESCVLSLKFAYCGKWFVSTGKD 599
Cdd:COG2319 230 LWDLATGKLLRTlTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGElLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 568926378 600 NLLNAWRTPYGASIFQSK-ESSSVLSCDISVDDKYIVTGSGDKKATVYEV 648
Cdd:COG2319 310 GTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
363-648 |
7.91e-43 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 159.31 E-value: 7.91e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 363 HGEVVCAVTISNPTRHVYTGGK-GCVKVWDIShpgNKSPVSQLDclNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAa 441
Cdd:COG2319 119 HTGAVRSVAFSPDGKTLASGSAdGTVRLWDLA---TGKLLRTLT--GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA- 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 442 pTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVR 521
Cdd:COG2319 193 -TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 522 SWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDK-YQLHLHESCVLSLKFAYCGKWFVSTGKD 599
Cdd:COG2319 272 LWDLATGELLRTlTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKTLASGSDD 351
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 568926378 600 NLLNAWRTPYGASIFQSKE-SSSVLSCDISVDDKYIVTGSGDKKATVYEV 648
Cdd:COG2319 352 GTVRLWDLATGELLRTLTGhTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
363-647 |
2.60e-38 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 143.63 E-value: 2.60e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 363 HGEVVCAVTISNPTRHVYTGGK-GCVKVWDIShpgNKSPVSQLdCLNRDNyIRSCKLLPDGCTLIVGGEASTLSIWDLaa 441
Cdd:cd00200 8 HTGGVTCVAFSPDGKLLATGSGdGTIKVWDLE---TGELLRTL-KGHTGP-VRDVAASADGTYLASGSSDKTIRLWDL-- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 442 PTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVR 521
Cdd:cd00200 81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 522 SWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPD-KYQLHLHESCVLSLKFAYCGKWFVSTGKD 599
Cdd:cd00200 161 LWDLRTGKCVATlTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKcLGTLRGHENGVNSVAFSPDGYLLASGSED 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 568926378 600 NLLNAWRTPYGASIFQ-SKESSSVLSCDISVDDKYIVTGSGDKKATVYE 647
Cdd:cd00200 241 GTIRVWDLRTGECVQTlSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
356-608 |
4.10e-38 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 145.82 E-value: 4.10e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 356 RQINTLN-HGEVVCAVTISNPTRHVYTGGK-GCVKVWDIShpgNKSPVSQLDclNRDNYIRSCKLLPDGCTLIVGGEAST 433
Cdd:COG2319 153 KLLRTLTgHSGAVTSVAFSPDGKLLASGSDdGTVRLWDLA---TGKLLRTLT--GHTGAVRSVAFSPDGKLLASGSADGT 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 434 LSIWDLAapTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWT 513
Cdd:COG2319 228 VRLWDLA--TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 514 GGLDNTVRSWDLREGRQLQQHD-FTSQIFSLGYCPTGEWLAVGMESSNVEVLHVN-KPDKYQLHLHESCVLSLKFAYCGK 591
Cdd:COG2319 306 GSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAtGELLRTLTGHTGAVTSVAFSPDGR 385
|
250
....*....|....*..
gi 568926378 592 WFVSTGKDNLLNAWRTP 608
Cdd:COG2319 386 TLASGSADGTVRLWDLA 402
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
413-648 |
2.75e-30 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 123.48 E-value: 2.75e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 413 IRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPacYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQF 492
Cdd:COG2319 39 VASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV--LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 493 QGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDK 571
Cdd:COG2319 117 TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTlTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL 196
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568926378 572 YQ-LHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSK-ESSSVLSCDISVDDKYIVTGSGDKKATVYEV 648
Cdd:COG2319 197 LRtLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
457-648 |
4.59e-26 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 108.58 E-value: 4.59e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 457 CYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQ-HD 535
Cdd:cd00200 12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTlTG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 536 FTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPD-KYQLHLHESCVLSLKFAyCGKWFVSTGK-DNLLNAWRTPYGASI 613
Cdd:cd00200 92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKcLTTLRGHTDWVNSVAFS-PDGTFVASSSqDGTIKLWDLRTGKCV 170
|
170 180 190
....*....|....*....|....*....|....*..
gi 568926378 614 --FQSkESSSVLSCDISVDDKYIVTGSGDKKATVYEV 648
Cdd:cd00200 171 atLTG-HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL 206
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
488-648 |
4.61e-20 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 90.86 E-value: 4.61e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 488 LVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREG---RQLQQHdfTSQIFSLGYCPTGEWLAVGMESSNVEVL 564
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGellRTLKGH--TGPVRDVAASADGTYLASGSSDKTIRLW 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 565 HVNKPDK-YQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASI--FQSKEsSSVLSCDISVDDKYIVTGSGDK 641
Cdd:cd00200 79 DLETGECvRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLttLRGHT-DWVNSVAFSPDGTFVASSSQDG 157
|
....*..
gi 568926378 642 KATVYEV 648
Cdd:cd00200 158 TIKLWDL 164
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
431-648 |
2.29e-19 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 90.74 E-value: 2.29e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 431 ASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTK 510
Cdd:COG2319 13 SADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 511 LWTGGLDNTVRSWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDK-YQLHLHESCVLSLKFAY 588
Cdd:COG2319 93 LASASADGTVRLWDLATGLLLRTlTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLlRTLTGHSGAVTSVAFSP 172
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568926378 589 CGKWFVSTGKDNLLNAWRTPYGASIFQ-SKESSSVLSCDISVDDKYIVTGSGDKKATVYEV 648
Cdd:COG2319 173 DGKLLASGSDDGTVRLWDLATGKLLRTlTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
356-485 |
3.92e-12 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 68.40 E-value: 3.92e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 356 RQINTLN-HGEVVCAVTISNPTRHVYTGGKGC-VKVWDIShpgNKSPVSQLDclNRDNYIRSCKLLPDGCTLIVGGEAST 433
Cdd:COG2319 279 ELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGtVRLWDLA---TGKLLRTLT--GHTGAVRSVAFSPDGKTLASGSDDGT 353
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 568926378 434 LSIWDLAapTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHN 485
Cdd:COG2319 354 VRLWDLA--TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
485-524 |
3.22e-07 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 46.92 E-value: 3.22e-07
10 20 30 40
....*....|....*....|....*....|....*....|
gi 568926378 485 NQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWD 524
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
475-646 |
6.92e-07 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 52.40 E-value: 6.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 475 DGNIAVWDLHNQTLVRQFQGHTDGASCIDISN-DGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGY-CPTGEWL 552
Cdd:PLN00181 554 EGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFpSESGRSL 633
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 553 AVGMESSNVEVLHVNKPdkyQLHL-----HESCVLSLKFAYCGKwFVSTGKDNLLNAWRTPYGASIFQSKESSSVLS--- 624
Cdd:PLN00181 634 AFGSADHKVYYYDLRNP---KLPLctmigHSKTVSYVRFVDSST-LVSSSTDNTLKLWDLSMSISGINETPLHSFMGhtn 709
|
170 180
....*....|....*....|....*.
gi 568926378 625 ----CDISVDDKYIVTGSGDKKATVY 646
Cdd:PLN00181 710 vknfVGLSVSDGYIATGSETNEVFVY 735
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
487-524 |
3.99e-06 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 43.87 E-value: 3.99e-06
10 20 30
....*....|....*....|....*....|....*...
gi 568926378 487 TLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWD 524
Cdd:pfam00400 2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| NBCH_WD40 |
pfam20426 |
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ... |
448-529 |
7.57e-04 |
|
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.
Pssm-ID: 466575 [Multi-domain] Cd Length: 350 Bit Score: 42.37 E-value: 7.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 448 AELTSSAPACYALAISPDSKVCFSCcsdGNiavWD-------LHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTV 520
Cdd:pfam20426 75 AENVELGAQCFATLQTPSENFLISC---GN---WEnsfqvisLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTV 148
|
....*....
gi 568926378 521 RSWDLREGR 529
Cdd:pfam20426 149 MVWEVLRGR 157
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
443-482 |
7.62e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 37.29 E-value: 7.62e-04
10 20 30 40
....*....|....*....|....*....|....*....|
gi 568926378 443 TPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWD 482
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
185-347 |
7.01e-03 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 39.67 E-value: 7.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 185 HEKANTPVLKSSTPTPRSdmPTPGTSATPGLRPGLGKPPAMEPLVNQAAAGLRTPLavPGPYPAPFGMVPHAGMNGELTS 264
Cdd:PHA03378 671 HIPYQPSPTGANTMLPIQ--WAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRA--RPPAAAPGRARPPAAAPGRARP 746
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926378 265 PGAAYAGLHsmSPQMSAAAAaaaaavvaygRSPMVGFDPPPHMRVPSIPPNLAGIPGGKPAysfhvtadgQMQPVPFPPD 344
Cdd:PHA03378 747 PAAAPGRAR--PPAAAPGRA----------RPPAAAPGAPTPQPPPQAPPAPQQRPRGAPT---------PQPPPQAGPT 805
|
...
gi 568926378 345 ALI 347
Cdd:PHA03378 806 SMQ 808
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
458-482 |
8.39e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 34.63 E-value: 8.39e-03
|
| |
