NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568931058|ref|XP_006538842|]
View 

eukaryotic translation initiation factor 4 gamma 3 isoform X3 [Mus musculus]

Protein Classification

eukaryotic translation initiation factor 4 gamma 3( domain architecture ID 10501431)

eukaryotic translation initiation factor 4 gamma 3 (EIF4G3) is component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome

CATH:  1.25.40.180
Gene Ontology:  GO:0003743|GO:0003743|GO:0000339|GO:0003723|GO:0003729|GO:0006446
PubMed:  10872469|12867079|9019810|27694156
SCOP:  4000569

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 917-1145 7.56e-64

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


:

Pssm-ID: 397130  Cd Length: 203  Bit Score: 216.08  E-value: 7.56e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   917 FRKVRSILNKLTPQMFNQLMKQVSALTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVTLkvpmadkpgNTVNFR 996
Cdd:pfam02854    1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLR---------NPTDFG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   997 KLLLNRCQKEFEKdkadddvfekkqkeleaasapeertrlHDELEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCV 1076
Cdd:pfam02854   72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568931058  1077 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERK---TSSRIRFMLQDVIDLRLCN 1145
Cdd:pfam02854  125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVLSKDdpkLSSRLRFMLQDLIELRKNK 203
W2_eIF4G1_like cd11559
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ...
 1585-1717 4.75e-49

C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.


:

Pssm-ID: 211397  Cd Length: 134  Bit Score: 170.93  E-value: 4.75e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058 1585 EELSQRLEKLIMEEKADDErIFDWVEANLDESQMSSPTFLRALMTAVCKAAIIADcSTFRVDTAVIKQRVPILLKYLDSD 1664
Cdd:cd11559     4 LRVQAELLKLLQEDPNPDE-LYKWIKENVSPELYASPGFVRALMTAVLKYAIEEK-SLPEKEKALLEKYAPLLQKYLDDD 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568931058 1665 TEKELQALYALQASIVKLDQPANLLRMFFDCLYDEEVISEDAFYKWESSKDPA 1717
Cdd:cd11559    82 EQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
 1383-1495 2.39e-35

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


:

Pssm-ID: 397128  Cd Length: 113  Bit Score: 130.86  E-value: 2.39e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  1383 VERKSKSIIDEFLHINDFKEATQCIEELSAQGPLHVFVKVGVEFTLERSQITRDHMGHLLYQLVQSEKLSKQDFFKGFSE 1462
Cdd:pfam02847    1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 568931058  1463 TLELADDMAIDIPHIWLYLAELVTPMLKGGGIS 1495
Cdd:pfam02847   81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 57-476 1.79e-11

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 69.97  E-value: 1.79e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   57 RALQTPAPQQIPRGPVqqpledrlFPPTVSavysTVTQVARQPGPPTPAPYSAHEISKGLPSLAATPPGHASSPGLSQTP 136
Cdd:PHA03247 2672 RAAQASSPPQRPRRRA--------ARPTVG----SLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAP 2739

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  137 YPSGQNAGPATlvyPQAPQTMNSQPQARSPFAAGPRPAhhqffqrPQIQPPRAAIPNSSPSIRPGVQTPTAVYQANQHim 216
Cdd:PHA03247 2740 APPAVPAGPAT---PGGPARPARPPTTAGPPAPAPPAA-------PAAGPPRRLTRPAVASLSESRESLPSPWDPADP-- 2807

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  217 mvnhlpmPYPVTqGHQYCIPQYRHSGPPYVGPPQQYPVQPPGPGPFYPGPGPGDFANAYGTPFYPSQPVYQSAPiiVPTQ 296
Cdd:PHA03247 2808 -------PAAVL-APAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAA--KPAA 2877

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  297 QQPPPAKREKKTIRIRDPNqggkdiTEEIMSGGGSRNPTPPIGRPASTPTPPQQLPSQVPEHSPvvygtvesahlAASTP 376
Cdd:PHA03247 2878 PARPPVRRLARPAVSRSTE------SFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPP-----------PPRPQ 2940

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  377 VTAASDQKQEEKPKPDPVFQSPStvLRLVLSGEKKEQAGQMPETAAGEPTPEPPrTSSPTSLPPLARSSLPSPMSAALSS 456
Cdd:PHA03247 2941 PPLAPTTDPAGAGEPSGAVPQPW--LGALVPGRVAVPRFRVPQPAPSREAPASS-TPPLTGHSLSRVSSWASSLALHEET 3017

                         410       420
                  ....*....|....*....|
gi 568931058  457 QPLFTAEDKCELPSSKEEDA 476
Cdd:PHA03247 3018 DPPPVSLKQTLWPPDDTEDS 3037
W2 super family cl17013
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of ...
 1696-1742 8.85e-05

C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of several translation initiation factors, including the epsilon chain of eIF2b, where it has been found to catalyze the conversion of eIF2.GDP to its active eIF2.GTP form. The structure of the domain resembles that of a set of concatenated HEAT repeats.


The actual alignment was detected with superfamily member cd11560:

Pssm-ID: 473053 [Multi-domain]  Cd Length: 194  Bit Score: 45.28  E-value: 8.85e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 568931058 1696 LYDEEVISEDAFYKWesSKDPAEQAGKGVALKSVTAFFTWLREAEEE 1742
Cdd:cd11560   150 LYKADVLSEDAILKW--YKKGHSPKGKQVFLKQMEPFVEWLQEAEEE 194
 
Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 917-1145 7.56e-64

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 216.08  E-value: 7.56e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   917 FRKVRSILNKLTPQMFNQLMKQVSALTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVTLkvpmadkpgNTVNFR 996
Cdd:pfam02854    1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLR---------NPTDFG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   997 KLLLNRCQKEFEKdkadddvfekkqkeleaasapeertrlHDELEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCV 1076
Cdd:pfam02854   72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568931058  1077 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERK---TSSRIRFMLQDVIDLRLCN 1145
Cdd:pfam02854  125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVLSKDdpkLSSRLRFMLQDLIELRKNK 203
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 918-1142 4.00e-51

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 179.48  E-value: 4.00e-51
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058    918 RKVRSILNKLTPQMFNQLMKQVSALTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVtLKVPmadkpgntvNFRK 997
Cdd:smart00543    2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLN-AKNP---------DFGS 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058    998 LLLNRCQKEFEKDkadddvfekkqkeleaasapeertrlhdeLEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCVV 1077
Cdd:smart00543   72 LLLERLQEEFEKG-----------------------------LESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLK 122

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568931058   1078 KLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERKT---SSRIRFMLQDVIDLR 1142
Cdd:smart00543  123 ELLNDLtkldpprSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKDKtelSSRLRFMLELLIELR 197
W2_eIF4G1_like cd11559
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ...
 1585-1717 4.75e-49

C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.


Pssm-ID: 211397  Cd Length: 134  Bit Score: 170.93  E-value: 4.75e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058 1585 EELSQRLEKLIMEEKADDErIFDWVEANLDESQMSSPTFLRALMTAVCKAAIIADcSTFRVDTAVIKQRVPILLKYLDSD 1664
Cdd:cd11559     4 LRVQAELLKLLQEDPNPDE-LYKWIKENVSPELYASPGFVRALMTAVLKYAIEEK-SLPEKEKALLEKYAPLLQKYLDDD 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568931058 1665 TEKELQALYALQASIVKLDQPANLLRMFFDCLYDEEVISEDAFYKWESSKDPA 1717
Cdd:cd11559    82 EQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
 1383-1495 2.39e-35

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


Pssm-ID: 397128  Cd Length: 113  Bit Score: 130.86  E-value: 2.39e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  1383 VERKSKSIIDEFLHINDFKEATQCIEELSAQGPLHVFVKVGVEFTLERSQITRDHMGHLLYQLVQSEKLSKQDFFKGFSE 1462
Cdd:pfam02847    1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 568931058  1463 TLELADDMAIDIPHIWLYLAELVTPMLKGGGIS 1495
Cdd:pfam02847   81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
 1383-1495 1.06e-32

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


Pssm-ID: 214714  Cd Length: 113  Bit Score: 123.12  E-value: 1.06e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   1383 VERKSKSIIDEFLHINDFKEATQCIEELSAQGPLHVFVKVGVEFTLERSQITRDHMGHLLYQLVQSEKLSKQDFFKGFSE 1462
Cdd:smart00544    1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFWR 80

                            90       100       110
                    ....*....|....*....|....*....|...
gi 568931058   1463 TLELADDMAIDIPHIWLYLAELVTPMLKGGGIS 1495
Cdd:smart00544   81 LLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
1655-1739 1.23e-28

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 110.46  E-value: 1.23e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   1655 PILLKYLDSDTEKELQALYALQASIVKLDQPANLLRMFFDCLYDEEVISEDAFYKWESSKDPAEqaGKGVALKSVTAFFT 1734
Cdd:smart00515    1 GPLLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSAE--GKKKVRKNAKPFVT 78


                    ....*
gi 568931058   1735 WLREA 1739
Cdd:smart00515   79 WLQEA 83
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
 1668-1744 2.88e-24

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 97.60  E-value: 2.88e-24
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568931058  1668 ELQALYALQASIVKLDQPANLLRMFFDCLYDEEVISEDAFYKWESSKDPAEQaGKGVALKSVTAFFTWLREAEEESE 1744
Cdd:pfam02020    1 QVDLLLALQEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWWEDVSSAEK-GMKKVRKQAKPFVEWLEEAEEESD 76
PHA03247 PHA03247
large tegument protein UL36; Provisional
 57-476 1.79e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 69.97  E-value: 1.79e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   57 RALQTPAPQQIPRGPVqqpledrlFPPTVSavysTVTQVARQPGPPTPAPYSAHEISKGLPSLAATPPGHASSPGLSQTP 136
Cdd:PHA03247 2672 RAAQASSPPQRPRRRA--------ARPTVG----SLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAP 2739

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  137 YPSGQNAGPATlvyPQAPQTMNSQPQARSPFAAGPRPAhhqffqrPQIQPPRAAIPNSSPSIRPGVQTPTAVYQANQHim 216
Cdd:PHA03247 2740 APPAVPAGPAT---PGGPARPARPPTTAGPPAPAPPAA-------PAAGPPRRLTRPAVASLSESRESLPSPWDPADP-- 2807

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  217 mvnhlpmPYPVTqGHQYCIPQYRHSGPPYVGPPQQYPVQPPGPGPFYPGPGPGDFANAYGTPFYPSQPVYQSAPiiVPTQ 296
Cdd:PHA03247 2808 -------PAAVL-APAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAA--KPAA 2877

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  297 QQPPPAKREKKTIRIRDPNqggkdiTEEIMSGGGSRNPTPPIGRPASTPTPPQQLPSQVPEHSPvvygtvesahlAASTP 376
Cdd:PHA03247 2878 PARPPVRRLARPAVSRSTE------SFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPP-----------PPRPQ 2940

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  377 VTAASDQKQEEKPKPDPVFQSPStvLRLVLSGEKKEQAGQMPETAAGEPTPEPPrTSSPTSLPPLARSSLPSPMSAALSS 456
Cdd:PHA03247 2941 PPLAPTTDPAGAGEPSGAVPQPW--LGALVPGRVAVPRFRVPQPAPSREAPASS-TPPLTGHSLSRVSSWASSLALHEET 3017

                         410       420
                  ....*....|....*....|
gi 568931058  457 QPLFTAEDKCELPSSKEEDA 476
Cdd:PHA03247 3018 DPPPVSLKQTLWPPDDTEDS 3037
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 99-518 6.60e-07

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 54.39  E-value: 6.60e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058    99 PGPPTPAPYSAHEISKGLPSLAATPPGHASSPGLSQTPYPSGQNAGPATLVypqapqtmNSQPQARSPFAAGPRPAHHQF 178
Cdd:pfam03154  181 ASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLI--------QQTPTLHPQRLPSPHPPLQPM 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   179 fqrPQIQPPRAAIPNSSPSirPGVQTPTAvyqanqhimmvnhlPMPYPVTQGHqyciPQYRHSGPPYVGPPQQYPVQPPG 258
Cdd:pfam03154  253 ---TQPPPPSQVSPQPLPQ--PSLHGQMP--------------PMPHSLQTGP----SHMQHPVPPQPFPLTPQSSQSQV 309

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   259 PGPFYPGPGPGDFANAYgTPfyPSQPVYQSAPiivPTQQQP-PPAKRekktirirdpnqggkditeeimsgggsrnPTPP 337
Cdd:pfam03154  310 PPGPSPAAPGQSQQRIH-TP--PSQSQLQSQQ---PPREQPlPPAPL-----------------------------SMPH 354

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   338 IGRPASTPTPPQQLPsQVPEHSPvvygtvesaHLAASTPVTAASDQkqeekpKPDPVFQSPSTVLRLVLSGEKKEQAGQM 417
Cdd:pfam03154  355 IKPPPTTPIPQLPNP-QSHKHPP---------HLSGPSPFQMNSNL------PPPPALKPLSSLSTHHPPSAHPPPLQLM 418

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   418 PETAAGEPTP-EPPRTSSPTSLPPLARSSLPSPMSAALSSQPLFTAEDKceLPSSKEEDAPPVPSPTScTAASGPSLtdn 496
Cdd:pfam03154  419 PQSQQLPPPPaQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPF--VPGGPPPITPPSGPPTS-TSSAMPGI--- 492

                          410       420
                   ....*....|....*....|..
gi 568931058   497 sdicKKPCSVAPHDSQLISSTI 518
Cdd:pfam03154  493 ----QPPSSASVSSSGPVPAAV 510
W2_eIF5C_like cd11560
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; ...
 1696-1742 8.85e-05

C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; eIF5C appears to be essential for the initiation of protein translation; its actual function, and specifically that of the C-terminal W2 domain, are not well understood. The Drosophila ortholog, kra (krasavietz) or exba (extra bases), may be involved in translational inhibition in neural development. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211398 [Multi-domain]  Cd Length: 194  Bit Score: 45.28  E-value: 8.85e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 568931058 1696 LYDEEVISEDAFYKWesSKDPAEQAGKGVALKSVTAFFTWLREAEEE 1742
Cdd:cd11560   150 LYKADVLSEDAILKW--YKKGHSPKGKQVFLKQMEPFVEWLQEAEEE 194
 
Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 917-1145 7.56e-64

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 216.08  E-value: 7.56e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   917 FRKVRSILNKLTPQMFNQLMKQVSALTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVTLkvpmadkpgNTVNFR 996
Cdd:pfam02854    1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLR---------NPTDFG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   997 KLLLNRCQKEFEKdkadddvfekkqkeleaasapeertrlHDELEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCV 1076
Cdd:pfam02854   72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568931058  1077 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERK---TSSRIRFMLQDVIDLRLCN 1145
Cdd:pfam02854  125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVLSKDdpkLSSRLRFMLQDLIELRKNK 203
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 918-1142 4.00e-51

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 179.48  E-value: 4.00e-51
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058    918 RKVRSILNKLTPQMFNQLMKQVSALTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVtLKVPmadkpgntvNFRK 997
Cdd:smart00543    2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLN-AKNP---------DFGS 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058    998 LLLNRCQKEFEKDkadddvfekkqkeleaasapeertrlhdeLEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCVV 1077
Cdd:smart00543   72 LLLERLQEEFEKG-----------------------------LESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLK 122

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568931058   1078 KLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERKT---SSRIRFMLQDVIDLR 1142
Cdd:smart00543  123 ELLNDLtkldpprSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKDKtelSSRLRFMLELLIELR 197
W2_eIF4G1_like cd11559
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ...
 1585-1717 4.75e-49

C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.


Pssm-ID: 211397  Cd Length: 134  Bit Score: 170.93  E-value: 4.75e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058 1585 EELSQRLEKLIMEEKADDErIFDWVEANLDESQMSSPTFLRALMTAVCKAAIIADcSTFRVDTAVIKQRVPILLKYLDSD 1664
Cdd:cd11559     4 LRVQAELLKLLQEDPNPDE-LYKWIKENVSPELYASPGFVRALMTAVLKYAIEEK-SLPEKEKALLEKYAPLLQKYLDDD 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568931058 1665 TEKELQALYALQASIVKLDQPANLLRMFFDCLYDEEVISEDAFYKWESSKDPA 1717
Cdd:cd11559    82 EQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
 1383-1495 2.39e-35

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


Pssm-ID: 397128  Cd Length: 113  Bit Score: 130.86  E-value: 2.39e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  1383 VERKSKSIIDEFLHINDFKEATQCIEELSAQGPLHVFVKVGVEFTLERSQITRDHMGHLLYQLVQSEKLSKQDFFKGFSE 1462
Cdd:pfam02847    1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 568931058  1463 TLELADDMAIDIPHIWLYLAELVTPMLKGGGIS 1495
Cdd:pfam02847   81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
 1383-1495 1.06e-32

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


Pssm-ID: 214714  Cd Length: 113  Bit Score: 123.12  E-value: 1.06e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   1383 VERKSKSIIDEFLHINDFKEATQCIEELSAQGPLHVFVKVGVEFTLERSQITRDHMGHLLYQLVQSEKLSKQDFFKGFSE 1462
Cdd:smart00544    1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFWR 80

                            90       100       110
                    ....*....|....*....|....*....|...
gi 568931058   1463 TLELADDMAIDIPHIWLYLAELVTPMLKGGGIS 1495
Cdd:smart00544   81 LLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
1655-1739 1.23e-28

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 110.46  E-value: 1.23e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   1655 PILLKYLDSDTEKELQALYALQASIVKLDQPANLLRMFFDCLYDEEVISEDAFYKWESSKDPAEqaGKGVALKSVTAFFT 1734
Cdd:smart00515    1 GPLLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSAE--GKKKVRKNAKPFVT 78


                    ....*
gi 568931058   1735 WLREA 1739
Cdd:smart00515   79 WLQEA 83
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
 1668-1744 2.88e-24

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 97.60  E-value: 2.88e-24
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568931058  1668 ELQALYALQASIVKLDQPANLLRMFFDCLYDEEVISEDAFYKWESSKDPAEQaGKGVALKSVTAFFTWLREAEEESE 1744
Cdd:pfam02020    1 QVDLLLALQEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWWEDVSSAEK-GMKKVRKQAKPFVEWLEEAEEESD 76
W2 cd11473
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of ...
 1585-1711 4.48e-19

C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of several translation initiation factors, including the epsilon chain of eIF2b, where it has been found to catalyze the conversion of eIF2.GDP to its active eIF2.GTP form. The structure of the domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211395  Cd Length: 135  Bit Score: 85.22  E-value: 4.48e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058 1585 EELSQRLEKLIMEEKADDERIFDWVEANLDESQMSSPTFLRALMTAVCKAAIIADCSTF---RVDTAVIKQRVPILLKYL 1661
Cdd:cd11473     4 KKLRDSLLKELEEDKSSDVESVKAAKSKLDLDPISLEEVVKVLLTAVVNAVESADSISLtqkEQLVLVLKKYGPVLRELL 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568931058 1662 DSDTEKELQALYALQA--SIVKLDQPANLLRMFFDCLYDEEVISEDAFYKWE 1711
Cdd:cd11473    84 KLIKKDQLYLLLKIEKlcLQLKLSELISLLEKILDLLYDADVLSEEAILSWF 135
W2_eIF2B_epsilon cd11558
C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a ...
 1625-1744 2.37e-15

C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a heteropentameric complex which functions as a guanine nucleotide exchange factor in the recycling of eIF-2 during the initiation of translation in eukaryotes. The epsilon and gamma subunits are sequence similar and both are essential in yeast. Epsilon appears to be the catalytically active subunit, with gamma enhancing its activity. The C-terminal domain of the eIF2B epsilon subunit contains bipartite motifs rich in acidic and aromatic residues, which are responsible for the interaction with eIF2. The structure of the domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211396  Cd Length: 169  Bit Score: 75.37  E-value: 2.37e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058 1625 RALMTAVCK-AAIIADCSTFRVDTA---VIKQRVPILLKYLDSDTEkELQALYALQASIVKLDQPANLLRMFFDCLYDEE 1700
Cdd:cd11558    47 RAVVKALLElILEVSSTSTAELLEAlkkLLSKWGPLLENYVKSQDD-QVELLLALEEFCLESEEGGPLFAKLLHALYDLD 125

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 568931058 1701 VISEDAFYKWESSKDPAEQAGKGVALKSVTAFFTWLREAEEESE 1744
Cdd:cd11558   126 ILEEEAILEWWEEPDAGADEEMKKVRELVKKFIEWLEEAEEESD 169
PHA03247 PHA03247
large tegument protein UL36; Provisional
 57-476 1.79e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 69.97  E-value: 1.79e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   57 RALQTPAPQQIPRGPVqqpledrlFPPTVSavysTVTQVARQPGPPTPAPYSAHEISKGLPSLAATPPGHASSPGLSQTP 136
Cdd:PHA03247 2672 RAAQASSPPQRPRRRA--------ARPTVG----SLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAP 2739

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  137 YPSGQNAGPATlvyPQAPQTMNSQPQARSPFAAGPRPAhhqffqrPQIQPPRAAIPNSSPSIRPGVQTPTAVYQANQHim 216
Cdd:PHA03247 2740 APPAVPAGPAT---PGGPARPARPPTTAGPPAPAPPAA-------PAAGPPRRLTRPAVASLSESRESLPSPWDPADP-- 2807

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  217 mvnhlpmPYPVTqGHQYCIPQYRHSGPPYVGPPQQYPVQPPGPGPFYPGPGPGDFANAYGTPFYPSQPVYQSAPiiVPTQ 296
Cdd:PHA03247 2808 -------PAAVL-APAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAA--KPAA 2877

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  297 QQPPPAKREKKTIRIRDPNqggkdiTEEIMSGGGSRNPTPPIGRPASTPTPPQQLPSQVPEHSPvvygtvesahlAASTP 376
Cdd:PHA03247 2878 PARPPVRRLARPAVSRSTE------SFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPP-----------PPRPQ 2940

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  377 VTAASDQKQEEKPKPDPVFQSPStvLRLVLSGEKKEQAGQMPETAAGEPTPEPPrTSSPTSLPPLARSSLPSPMSAALSS 456
Cdd:PHA03247 2941 PPLAPTTDPAGAGEPSGAVPQPW--LGALVPGRVAVPRFRVPQPAPSREAPASS-TPPLTGHSLSRVSSWASSLALHEET 3017

                         410       420
                  ....*....|....*....|
gi 568931058  457 QPLFTAEDKCELPSSKEEDA 476
Cdd:PHA03247 3018 DPPPVSLKQTLWPPDDTEDS 3037
PHA03247 PHA03247
large tegument protein UL36; Provisional
 62-498 1.62e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 63.42  E-value: 1.62e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   62 PAPQQIPRGPVQQPledrlFPPTVSAVYSTVTQVARQPGPPTPAPySAHEISKGLPSLAATPPghasSPGLSQTPYPsGQ 141
Cdd:PHA03247 2592 PPQSARPRAPVDDR-----GDPRGPAPPSPLPPDTHAPDPPPPSP-SPAANEPDPHPPPTVPP----PERPRDDPAP-GR 2660

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  142 NAGPATLVYPQAPQTMNSQPQARSPFAAGPRPAHHQFFQRPqiqPPRAAIPNSSP-SIRPGVQTPTAVYQANQHIMMVNH 220
Cdd:PHA03247 2661 VSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADP---PPPPPTPEPAPhALVSATPLPPGPAAARQASPALPA 2737

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  221 LPMPYPVTQGHQYCIPQYRHSGPPYVGPPQQYPVQPpgpgpfypgpgpgdfANAYGTPfyPSQPVYQSAPIIVPTQQQPP 300
Cdd:PHA03247 2738 APAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPA---------------APAAGPP--RRLTRPAVASLSESRESLPS 2800

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  301 PAKREKKTIRIRDPNQggkdiTEEIMSGGGSRNPTPPIGRPASTPTPPQQLPSQVPEHSPVVYG---------TVESAHL 371
Cdd:PHA03247 2801 PWDPADPPAAVLAPAA-----ALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGgdvrrrppsRSPAAKP 2875

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  372 AASTPVTAASDQKQEEKPKPDPVFQSPSTVLRLVLSGEKKEQAGQMPETAAGEPTPEPPRTSSPTSLPPLARSSLPSPMS 451
Cdd:PHA03247 2876 AAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEP 2955

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 568931058  452 AALSSQPLFTAEDKCELPSSKEEDAPPVPS-PTSctAASGPSLTDNSD 498
Cdd:PHA03247 2956 SGAVPQPWLGALVPGRVAVPRFRVPQPAPSrEAP--ASSTPPLTGHSL 3001
W2_eIF5 cd11561
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase ...
 1597-1744 5.62e-09

C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase acceleration protein (GAP), as well as a GDP dissociation inhibitor (GDI) during translational initiation in eukaryotes. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211399  Cd Length: 157  Bit Score: 56.86  E-value: 5.62e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058 1597 EEKADD--ERIFDWVEANLDESQMS-------SPTFLRALMTAVCkaAIIADCsTFRVDTA-VIKQRVPILLKYLDSDte 1666
Cdd:cd11561     1 EEEEDErvDELGEFLKKNKDESGLSelkeilkEAERLDVVKDKAV--LVLAEV-LFDENIVkEIKKRKALLLKLVTDE-- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058 1667 kelQALYALQASIVKL--DQPANLLRMF---FDCLYDEEVISEDAFYKWeSSKDPAEQAGKGVA---LKSVTAFFTWLRE 1738
Cdd:cd11561    76 ---KAQKALLGGIERFcgKHSPELLKKVpliLKALYDNDILEEEVILKW-YEKVSKKYVSKEKSkkvRKAAEPFVEWLEE 151


                  ....*.
gi 568931058 1739 AEEESE 1744
Cdd:cd11561   152 AEEEEE 157
PHA03247 PHA03247
large tegument protein UL36; Provisional
 58-445 7.73e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.64  E-value: 7.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   58 ALQTPAPQQIPRGPVQQPLEDRLFP--PTVSAVYSTVTQVARQPGPPTPAPYSAHEISKGLPSLAATPPGHAS-SPGLSQ 134
Cdd:PHA03247 2718 ATPLPPGPAAARQASPALPAAPAPPavPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASlSESRES 2797

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  135 TPYPSGQNAGPATLVYPQAPQTMNSQPQARSPFAAGPRPAHHQF---FQRPQIQPPRAAIPNSSPSIRPGVQTPTAVYQA 211
Cdd:PHA03247 2798 LPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPppgPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAA 2877

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  212 NQHImMVNHLPMPYPVTQGHQYCIPQYRHSGPPyvgppqqypvqppgpgpfypgpgpgdfanaygTPFYPSQPVYQSAPI 291
Cdd:PHA03247 2878 PARP-PVRRLARPAVSRSTESFALPPDQPERPP--------------------------------QPQAPPPPQPQPQPP 2924

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  292 IVPTQQQPPPAKRekktiRIRDPNQGGKDITEEIMSGGGSRNPTPPIGRPASTPTPPQQLPSQVPEHSPVVYGTVESAHL 371
Cdd:PHA03247 2925 PPPQPQPPPPPPP-----RPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGH 2999

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  372 AASTPVTAASDQKQEEKPKPDPVfqspsTVLRLVLSGEKKEQA-------GQMPETAAGEPTPEPPRTSSPTSLPPLARS 444
Cdd:PHA03247 3000 SLSRVSSWASSLALHEETDPPPV-----SLKQTLWPPDDTEDSdadslfdSDSERSDLEALDPLPPEPHDPFAHEPDPAT 3074


                  .
gi 568931058  445 S 445
Cdd:PHA03247 3075 P 3075
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 99-518 6.60e-07

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 54.39  E-value: 6.60e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058    99 PGPPTPAPYSAHEISKGLPSLAATPPGHASSPGLSQTPYPSGQNAGPATLVypqapqtmNSQPQARSPFAAGPRPAHHQF 178
Cdd:pfam03154  181 ASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLI--------QQTPTLHPQRLPSPHPPLQPM 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   179 fqrPQIQPPRAAIPNSSPSirPGVQTPTAvyqanqhimmvnhlPMPYPVTQGHqyciPQYRHSGPPYVGPPQQYPVQPPG 258
Cdd:pfam03154  253 ---TQPPPPSQVSPQPLPQ--PSLHGQMP--------------PMPHSLQTGP----SHMQHPVPPQPFPLTPQSSQSQV 309

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   259 PGPFYPGPGPGDFANAYgTPfyPSQPVYQSAPiivPTQQQP-PPAKRekktirirdpnqggkditeeimsgggsrnPTPP 337
Cdd:pfam03154  310 PPGPSPAAPGQSQQRIH-TP--PSQSQLQSQQ---PPREQPlPPAPL-----------------------------SMPH 354

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   338 IGRPASTPTPPQQLPsQVPEHSPvvygtvesaHLAASTPVTAASDQkqeekpKPDPVFQSPSTVLRLVLSGEKKEQAGQM 417
Cdd:pfam03154  355 IKPPPTTPIPQLPNP-QSHKHPP---------HLSGPSPFQMNSNL------PPPPALKPLSSLSTHHPPSAHPPPLQLM 418

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   418 PETAAGEPTP-EPPRTSSPTSLPPLARSSLPSPMSAALSSQPLFTAEDKceLPSSKEEDAPPVPSPTScTAASGPSLtdn 496
Cdd:pfam03154  419 PQSQQLPPPPaQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPF--VPGGPPPITPPSGPPTS-TSSAMPGI--- 492

                          410       420
                   ....*....|....*....|..
gi 568931058   497 sdicKKPCSVAPHDSQLISSTI 518
Cdd:pfam03154  493 ----QPPSSASVSSSGPVPAAV 510
PHA03378 PHA03378
EBNA-3B; Provisional
 60-488 7.12e-07

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 54.30  E-value: 7.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   60 QTPAPQQIPRGPVQQPLEDRLFPPTVsavystvtQVARQPGPPTPAPYSAHEISKGLPSLAATPPGhaSSPGLSQTPYPS 139
Cdd:PHA03378  446 HSQAPTVVLHRPPTQPLEGPTGPLSV--------QAPLEPWQPLPHPQVTPVILHQPPAQGVQAHG--SMLDLLEKDDED 515

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  140 GQNAGPATLVYPQAPQTMNSQpqaRSPFA------------AGPRPAHHQFFQRP-----QIQPPRAAIPNSSPSIRPGv 202
Cdd:PHA03378  516 MEQRVMATLLPPSPPQPRAGR---RAPCVytedldiesdepASTEPVHDQLLPAPglgplQIQPLTSPTTSQLASSAPS- 591

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  203 qtptavyqanqhimmvnHLPMPYPVTQGHQYCIPQYRHSGPPYVGPPQQYPVQPPGPGPFYPGPGPGDFaNAYGTPfYPS 282
Cdd:PHA03378  592 -----------------YAQTPWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPLRPIPMRPLRMQPITF-NVLVFP-TPH 652

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  283 QPVYQSAPIIVPTQQQPPPAKREkktirirdPNQGGKDITEEIMSGGGSRNP---TPPIGRPASTPTPPQQLPSQVPEHS 359
Cdd:PHA03378  653 QPPQVEITPYKPTWTQIGHIPYQ--------PSPTGANTMLPIQWAPGTMQPpprAPTPMRPPAAPPGRAQRPAAATGRA 724

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  360 PVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPSTVLRLVLSGEKKEQAGQMPETAA----GEPTPEPPRTSSP 435
Cdd:PHA03378  725 RPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQqrprGAPTPQPPPQAGP 804

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  436 TSLPPLARSSLPSPMSAALSSQPLFTAEDKCELPSSK-----EEDAP--PVPSPTSCTAA 488
Cdd:PHA03378  805 TSMQLMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKkpaalERQAAagPTPSPGSGTSD 864
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 120-244 4.23e-06

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 51.96  E-value: 4.23e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   120 AATPPGHASSPGLSQTPYPSGQNAGPATLVYPQAPQTMNSQPQArspfaaGPRPAHH-QFFQRPQIQPPRAAIPNSSPSI 198
Cdd:pfam09770  212 QQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQ------HPGQGHPvTILQRPQSPQPDPAQPSIQPQA 285

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 568931058   199 RPGVQTPTAVYQANQHIM------MVNHLPMPYPVTQGHQYCIPQYRHSGPP 244
Cdd:pfam09770  286 QQFHQQPPPVPVQPTQILqnpnrlSAARVGYPQNPQPGVQPAPAHQAHRQQG 337
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
328-492 1.77e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 49.85  E-value: 1.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  328 GGGSRNPTPPIGRPASTPTPPQQLPSQV-PEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPSTVLRLVL 406
Cdd:PRK07003  368 PGGGVPARVAGAVPAPGARAAAAVGASAvPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDA 447

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  407 SGEKKEQAGQMPETAAGEPTPEPPRTSSPTS-----LPPLARSSlPSPMSAALSSQPLFTAEDKCELPSSKEEDAPPVP- 480
Cdd:PRK07003  448 PVPAKANARASADSRCDERDAQPPADSGSASapasdAPPDAAFE-PAPRAAAPSAATPAAVPDARAPAAASREDAPAAAa 526

                         170
                  ....*....|..
gi 568931058  481 SPTSCTAASGPS 492
Cdd:PRK07003  527 PPAPEARPPTPA 538
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 5-435 3.82e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 48.61  E-value: 3.82e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058     5 QKPALKSGSAAAAGTGPGTGAAAAAAVPPPHPAAAAAAAAVAAAAApphpniralQTPAPQQIPRGP---VQQPLEdrLF 81
Cdd:pfam03154  170 QPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATS---------QPPNQTQSTAAPhtlIQQTPT--LH 238

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058    82 PPTVSAVYSTVTQvARQPGPPTPAPYSAHEiskglpslaaTPPGHASSPglsqtPYPSGQNAGPATLVYPQAPQTMNSQP 161
Cdd:pfam03154  239 PQRLPSPHPPLQP-MTQPPPPSQVSPQPLP----------QPSLHGQMP-----PMPHSLQTGPSHMQHPVPPQPFPLTP 302

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   162 Q-ARSPFAAGPRP-AHHQFFQRPQIQPPRAAIPNSSPsirPGVQTPTAVYQANQHImmvnhlpMPYPVTQGHQYCIPQyR 239
Cdd:pfam03154  303 QsSQSQVPPGPSPaAPGQSQQRIHTPPSQSQLQSQQP---PREQPLPPAPLSMPHI-------KPPPTTPIPQLPNPQ-S 371

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   240 HSGPPYVGPPQQypvqppgpgpfypgpgpgdFANAYGTPFYPSQPVYQSAPIIVPTQQQPPPAKREKKTIRIRDPNQGGK 319
Cdd:pfam03154  372 HKHPPHLSGPSP-------------------FQMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPP 432

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   320 DITE-EIMSGGGSRNPTPpigrPASTPTPPQqlpSQVPEHsPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVFQS- 397
Cdd:pfam03154  433 VLTQsQSLPPPAASHPPT----SGLHQVPSQ---SPFPQH-PFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSg 504

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|
gi 568931058   398 --PSTVLRLVLSGEKKEQAgqMPETAAGEPTPEPPRTSSP 435
Cdd:pfam03154  505 pvPAAVSCPLPPVQIKEEA--LDEAEEPESPPPPPRSPSP 542
W2_eIF5C_like cd11560
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; ...
 1696-1742 8.85e-05

C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; eIF5C appears to be essential for the initiation of protein translation; its actual function, and specifically that of the C-terminal W2 domain, are not well understood. The Drosophila ortholog, kra (krasavietz) or exba (extra bases), may be involved in translational inhibition in neural development. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211398 [Multi-domain]  Cd Length: 194  Bit Score: 45.28  E-value: 8.85e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 568931058 1696 LYDEEVISEDAFYKWesSKDPAEQAGKGVALKSVTAFFTWLREAEEE 1742
Cdd:cd11560   150 LYKADVLSEDAILKW--YKKGHSPKGKQVFLKQMEPFVEWLQEAEEE 194
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
328-498 2.15e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.02  E-value: 2.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  328 GGGSRNPTPPIGRPASTPTPPQQLPSQV-PEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPSTVLRlvl 406
Cdd:PRK12323  368 SGGGAGPATAAAAPVAQPAPAAAAPAAAaPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGP--- 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  407 SGEKKEQAGQMPETAAGEPTPEPPRTSSPTSLPPLARSSLPSPMSAALSSQPLFTAEDKCELPSSKEEDAPPVPSPTSCT 486
Cdd:PRK12323  445 GGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAE 524

                         170
                  ....*....|..
gi 568931058  487 AASGPSLTDNSD 498
Cdd:PRK12323  525 SIPDPATADPDD 536
Pneumo_att_G pfam05539
Pneumovirinae attachment membrane glycoprotein G;
277-463 3.60e-04

Pneumovirinae attachment membrane glycoprotein G;


Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 45.04  E-value: 3.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   277 TPFYPSQpvyqsapiiVPTQQQPPPAKREKKTIRIRDPNQGgkditeeimSGGGSRNPTPPIGRPASTPTPPQQLPSQVP 356
Cdd:pfam05539  186 HPTYPSQ---------VTPQSQPATQGHQTATANQRLSSTE---------PVGTQGTTTSSNPEPQTEPPPSQRGPSGSP 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   357 EHSPvvygtvesahlaaSTP----VTAASDQKQEEKPKPDPVFQSPSTVLRLVLSGEKKeqagqmPETAAGEPTPEPPRT 432
Cdd:pfam05539  248 QHPP-------------STTsqdqSTTGDGQEHTQRRKTPPATSNRRSPHSTATPPPTT------KRQETGRPTPRPTAT 308

                          170       180       190
                   ....*....|....*....|....*....|.
gi 568931058   433 SSPTSLPPlarSSLPSPMSAALSSQPLFTAE 463
Cdd:pfam05539  309 TQSGSSPP---HSSPPGVQANPTTQNLVDCK 336
PHA03378 PHA03378
EBNA-3B; Provisional
 65-362 3.62e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 45.44  E-value: 3.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   65 QQIPRGPVQQPLEDRlfPPTVSAVY--STVTQVARQPGPPTPAPYSAHEISKGLPSLAATP---PGHASSPglSQTPYPS 139
Cdd:PHA03378  639 QPITFNVLVFPTPHQ--PPQVEITPykPTWTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPpraPTPMRPP--AAPPGRA 714

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  140 GQNAGPATLVYPQAPQTMNSQPQARSPFAAGPRPAHHQFFQRPQIQPPRAAIPNSSPsirpGVQTPTAVYQANqhimmvn 219
Cdd:PHA03378  715 QRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAP----GAPTPQPPPQAP------- 783

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  220 hlpmPYPVTQGHQYCIPQYRHSGPPYVGPPQQYPVQPPGPGPFYPGPGPGDFANAYGTPF--YPS----------QPVYQ 287
Cdd:PHA03378  784 ----PAPQQRPRGAPTPQPPPQAGPTSMQLMPRAAPGQQGPTKQILRQLLTGGVKRGRPSlkKPAalerqaaagpTPSPG 859

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  288 S--------APIIVPTQQQPPPAKREKKTIRIRDPNQGGKDITEEI--MSGGGSRNPT--PPIGRPASTPTPPQQLPSQV 355
Cdd:PHA03378  860 SgtsdkivqAPVFYPPVLQPIQVMRQLGSVRAAAASTVTQAPTEYTgeRRGVGPMHPTdiPPSKRAKTDAYVESQPPHGG 939


                  ....*..
gi 568931058  356 PEHSPVV 362
Cdd:PHA03378  940 QSHSFSV 946
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 101-485 6.41e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 44.57  E-value: 6.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   101 PPTPAPYSAHEISKGLPSLAATPPGHASSPGLSQTPypsgqnAGPATlVYPQAPQTMNSQPQARSPfaaGPRPAHhqffq 180
Cdd:pfam17823  115 LAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAAC------RANAS-AAPRAAIAAASAPHAASP---APRTAA----- 179

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   181 rpqiQPPRAAIPNSSPSIRPGVQTPTAVYQAnqhimmvnhLPMPYPVTQGHQycipqyrhSGPPYVGPPQQYPVQPPGPG 260
Cdd:pfam17823  180 ----SSTTAASSTTAASSAPTTAASSAPATL---------TPARGISTAATA--------TGHPAAGTALAAVGNSSPAA 238

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   261 PFYPGPGPGDFANAYGTPFYPSQPVYQSAPII---VPTQQQPPPAKrekktirirdpnqggkditeEIMSGGGSRNPTPP 337
Cdd:pfam17823  239 GTVTAAVGTVTPAALATLAAAAGTVASAAGTInmgDPHARRLSPAK--------------------HMPSDTMARNPAAP 298

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   338 IGRPASTP------------TPPQQLPSqvPEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVfqsPSTvlrlv 405
Cdd:pfam17823  299 MGAQAQGPiiqvstdqpvhnTAGEPTPS--PSNTTLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPV---LHT----- 368

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   406 lsgekkeqaGQMPETAAGEPTPEPprtsSPtsLPPLARSSLPSPMSAALSSQPLFTAEDKCELPSSKEEDAPPVPSPTSC 485
Cdd:pfam17823  369 ---------SMIPEVEATSPTTQP----SP--LLPTQGAAGPGILLAPEQVATEATAGTASAGPTPRSSGDPKTLAMASC 433
PHA03378 PHA03378
EBNA-3B; Provisional
 57-207 6.83e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 44.67  E-value: 6.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   57 RALQTPAPQQIPRGPVQQP--LEDRLFPPTVSAVYSTVTQVARQPGPPTPAPYSAHEISKGLPSLAATPPGHASSPglsq 134
Cdd:PHA03378  699 RAPTPMRPPAAPPGRAQRPaaATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAP---- 774

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568931058  135 TPYPSGQnAGPATLVYPQAPQTMNSQPQA-RSPFAAGPRPAHHQffQRPQIQPPRAAIPNSSPSIRPGVQTPTA 207
Cdd:PHA03378  775 TPQPPPQ-APPAPQQRPRGAPTPQPPPQAgPTSMQLMPRAAPGQ--QGPTKQILRQLLTGGVKRGRPSLKKPAA 845
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 187-482 9.90e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 44.31  E-value: 9.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  187 PRAAIPNSSPSIR----PGVQTPTAVYQanqhimmvnhlPMPYPVTQGHQYCIPQYRHSGP---PYVGPPQQYPVQPPGP 259
Cdd:PRK10263  347 ASVDVPPAQPTVAwqpvPGPQTGEPVIA-----------PAPEGYPQQSQYAQPAVQYNEPlqqPVQPQQPYYAPAAEQP 415

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  260 gpfypgpgpgdfanaygtpfyPSQPVYQSAPIIVPTQQQPPPAKREKKTIRIRDPNQGGKDITEEimsggGSRNPTPPIG 339
Cdd:PRK10263  416 ---------------------AQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQ-----STYQTEQTYQ 469

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  340 RPAstPTPPQQLPSQVPEHSPVVYGTVESAHLAASTPVTAASDQKQEEK------------PKPDPVfqspstvlrlvls 407
Cdd:PRK10263  470 QPA--AQEPLYQQPQPVEQQPVVEPEPVVEETKPARPPLYYFEEVEEKRarereqlaawyqPIPEPV------------- 534

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568931058  408 gekKEQAGQMPETAAGEPTPEPPRTSSPTSLPPLA--RSSLPSPMSAALSSQPLFT-AEDKCELPSSKEEDAPPVPSP 482
Cdd:PRK10263  535 ---KEPEPIKSSLKAPSVAAVPPVEAAAAVSPLASgvKKATLATGAAATVAAPVFSlANSGGPRPQVKEGIGPQLPRP 609
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 340-495 2.21e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.85  E-value: 2.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  340 RPASTPTPPQQLPSQvpEHSPVVygTVESAHLAASTPV---TAASDQKQEEKPKPDPVFQSPS------TVLRLVLSGEK 410
Cdd:PHA03307   23 RPPATPGDAADDLLS--GSQGQL--VSDSAELAAVTVVagaAACDRFEPPTGPPPGPGTEAPAnesrstPTWSLSTLAPA 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  411 KEQAGQMPETAAGEPTPEPPRTSSPTSLPPLARSSLPSPMSAALSSQPLFTAEDKC-ELPSSKEEDAPPVPSPTSCTAAS 489
Cdd:PHA03307   99 SPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAaGASPAAVASDAASSRQAALPLSS 178


                  ....*.
gi 568931058  490 GPSLTD 495
Cdd:PHA03307  179 PEETAR 184
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 327-492 2.52e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 2.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  327 SGGGSRNPTPPIGRPASTPTPPQQLPSQVPehSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPSTVLRLVL 406
Cdd:PRK07764  601 PAPASSGPPEEAARPAAPAAPAAPAAPAPA--GAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAP 678

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  407 SGEKKEQAGQMPETAAGEPTPEP----------PRTSSPTSLPPLARSSLPSPMSAALSSQPLFTAEDKCELPSSKEEDA 476
Cdd:PRK07764  679 AAPPPAPAPAAPAAPAGAAPAQPapapaatppaGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQP 758

                         170
                  ....*....|....*.
gi 568931058  477 PPVPSPTSCTAASGPS 492
Cdd:PRK07764  759 PPPPAPAPAAAPAAAP 774
PRK11901 PRK11901
hypothetical protein; Reviewed
 281-408 2.55e-03

hypothetical protein; Reviewed


Pssm-ID: 237015 [Multi-domain]  Cd Length: 327  Bit Score: 41.98  E-value: 2.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  281 PSQPVYQSAPIIVPTQQQPPPAKREKKTIRIRDP---------NQGGKDITEEIMSGGGSRNPTPPIGRPASTPTPPQQL 351
Cdd:PRK11901  113 TAPPQDISAPPISPTPTQAAPPQTPNGQQRIELPgnisdalsqQQGQVNAASQNAQGNTSTLPTAPATVAPSKGAKVPAT 192

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  352 PSQVPEHSPVVYGT--VESAHLAASTPVTAASDQKQEEKPKPDPVFQS-PSTVLRLVLSG 408
Cdd:PRK11901  193 AETHPTPPQKPATKkpAVNHHKTATVAVPPATSGKPKSGAASARALSSaPASHYTLQLSS 252
PHA03378 PHA03378
EBNA-3B; Provisional
 57-429 2.60e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 42.75  E-value: 2.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   57 RALQTPAPQQIPRGPVQQPLEDRLFPPTVSAVysTVTQVARQPGPPTPAPYSAHEISKGLPSLAATPPGHASS------P 130
Cdd:PHA03378  614 HIPETSAPRQWPMPLRPIPMRPLRMQPITFNV--LVFPTPHQPPQVEITPYKPTWTQIGHIPYQPSPTGANTMlpiqwaP 691

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  131 GLSQTPypsgqNAGPATLVYPQAPQTMNSQPQArSPFAAGPRPAHHQFFQRPQIQPPRAAIPNSSPSirpGVQTPTAVYQ 210
Cdd:PHA03378  692 GTMQPP-----PRAPTPMRPPAAPPGRAQRPAA-ATGRARPPAAAPGRARPPAAAPGRARPPAAAPG---RARPPAAAPG 762

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  211 ANQHIMMVNHLPMPYPVTQGHQycIPQYRHSGPPyvgppqqypvqppgpgpfypgpgpgdfanaygTPFYPSQPVyqSAP 290
Cdd:PHA03378  763 RARPPAAAPGAPTPQPPPQAPP--APQQRPRGAP--------------------------------TPQPPPQAG--PTS 806

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  291 IIVPTQQQPPPAKREKKTIRIRDPNQGGKDITEEIMSGGGSR------NPTPPIGRPASTPT-----PPQQLPSQVPehs 359
Cdd:PHA03378  807 MQLMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAALERqaaagpTPSPGSGTSDKIVQapvfyPPVLQPIQVM--- 883

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  360 pvvyGTVESAHLAASTPVTAASDQKQEEKPKPDPVfqSPSTVLRlvlSGEKKEQAGQMPETAAGEPTPEP 429
Cdd:PHA03378  884 ----RQLGSVRAAAASTVTQAPTEYTGERRGVGPM--HPTDIPP---SKRAKTDAYVESQPPHGGQSHSF 944
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 62-174 4.29e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.01  E-value: 4.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   62 PAPQQIPRGPVQQPLEDRLFPPTVSAVYSTVTQVARQPGPPTPAPYSAHEISKGLPSLAATPPGHASSPGLSQTPYPSGQ 141
Cdd:PRK14951  375 PAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQ 454

                          90       100       110
                  ....*....|....*....|....*....|...
gi 568931058  142 NAgPATLVYPQAPQTMNSQPQARSPFAAGPRPA 174
Cdd:PRK14951  455 AA-PETVAIPVRVAPEPAVASAAPAPAAAPAAA 486
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 352-493 5.76e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.61  E-value: 5.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  352 PSQVPEHSPVVYGTVESAHLAASTPVTAASdqkQEEKPKPDPVFQSPStvlrlVLSGEKKEQAGQMP-ETAAGEPTPEPP 430
Cdd:PRK10263  301 QPEYDEYDPLLNGAPITEPVAVAAAATTAT---QSWAAPVEPVTQTPP-----VASVDVPPAQPTVAwQPVPGPQTGEPV 372

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568931058  431 RTSSPTSLPPLARSSLPSPMSAALSSQPlFTAEDKCELPSSKEEDAPPVPSPTSCTAASGPSL 493
Cdd:PRK10263  373 IAPAPEGYPQQSQYAQPAVQYNEPLQQP-VQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYY 434
DUF4045 pfam13254
Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. ...
 294-477 8.93e-03

Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. This domain family is found in bacteria and eukaryotes, and is typically between 384 and 430 amino acids in length.


Pssm-ID: 433066 [Multi-domain]  Cd Length: 415  Bit Score: 40.54  E-value: 8.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   294 PTQQQPPPAKREKKTIRirdPNQGGKDiteeiMSGGGSRNPTPPIGRPASTPTPPQQLPSQVPEHSPVVYGTVESAHLAA 373
Cdd:pfam13254  170 PSQPAQPAWMKELNKIR---QSRASVD-----LGRPNSFKEVTPVGLMRSPAPGGHSKSPSVSGISADSSPTKEEPSEEA 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   374 STPVTaasdqKQEEKPKPDPVFQSPSTVLRLvlsgEKKEQAGQMPETAAGEPT--PEPPRTSSPTSLPPLARSSLPSPMS 451
Cdd:pfam13254  242 DTLST-----DKEQSPAPTSASEPPPKTKEL----PKDSEEPAAPSKSAEASTekKEPDTESSPETSSEKSAPSLLSPVS 312

                          170       180
                   ....*....|....*....|....*.
gi 568931058   452 AALSSQPLFTAEDKCELPSSKEEDAP 477
Cdd:pfam13254  313 KASIDKPLSSPDRDPLSPKPKPQSPP 338
PHA03247 PHA03247
large tegument protein UL36; Provisional
 39-492 9.35e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 9.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058   39 AAAAAAVAAAAAPPHPNIRALQTP-----------APQQIPRGPVQQPLEDRLFpPTVSAVYSTVTQVARQPGPPTP--A 105
Cdd:PHA03247 2481 RRPAEARFPFAAGAAPDPGGGGPPdpdappapsrlAPAILPDEPVGEPVHPRML-TWIRGLEELASDDAGDPPPPLPpaA 2559

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  106 PYSAHEISKGLPSLAATPPGHA--------SSPGLSQTPY----PSGQNAGPATLVyPQAPQTMNSQPQARSPFAAGPRP 173
Cdd:PHA03247 2560 PPAAPDRSVPPPRPAPRPSEPAvtsrarrpDAPPQSARPRapvdDRGDPRGPAPPS-PLPPDTHAPDPPPPSPSPAANEP 2638

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  174 AHHQFFQRPQIQPPRAAIPNSSPSIRPGVQTPTAVYQANQHIMMVNHLPMPYPVTQGHQYCIPqyrhSGPPYVGPPQQYP 253
Cdd:PHA03247 2639 DPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADP----PPPPPTPEPAPHA 2714

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  254 VQPPGPGPFYPGPGPGDFANAYGTPFYPSQPVYQSAPIIVPTQQQPPPAKREKKTIRIRDPnqggkditeeimSGGGSRN 333
Cdd:PHA03247 2715 LVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAP------------AAGPPRR 2782

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  334 PTPPIGRPASTPTPPQQLPSQVPEHSPVVYG--TVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPSTVLRLVLSG--- 408
Cdd:PHA03247 2783 LTRPAVASLSESRESLPSPWDPADPPAAVLApaAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGgdv 2862

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931058  409 EKKEQAGQMPETAAGE--------PTPEPPRTSSPTSLPPLARSSLPSPMSAA--LSSQPLFTAEDKCELPSSKEEDAPP 478
Cdd:PHA03247 2863 RRRPPSRSPAAKPAAParppvrrlARPAVSRSTESFALPPDQPERPPQPQAPPppQPQPQPPPPPQPQPPPPPPPRPQPP 2942

                         490
                  ....*....|....
gi 568931058  479 VPSPTSCTAASGPS 492
Cdd:PHA03247 2943 LAPTTDPAGAGEPS 2956
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH